MUKAI Mutsuko 向井睦子

Researcher Number	20342991
Affiliation (based on the past Project Information) *help	2006: Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka Prefectural Hospital Organization, Principal investigator, 研究所, 主任研究員 2006: 地方独立行政法人大阪府立病院機構大阪府立成人病センター, 研究所, 主任研究員 2006: 地方独立行政法人大阪府立病院機構大阪府立成人病センター, 研究所, 研究員 2005: 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 生化学部, 主任研究員 2004: MUKAI,Mutsuko, 主任研究員 2004: 大阪府立成人病センター, 研究所, 主任研究員 2003: 大阪府立成人病センター, 研究所・生化学部, 主任研究員
Review Section/Research Field	Principal Investigator Radiation science Except Principal Investigator Pathological medical chemistry / Experimental pathology
Keywords	Principal Investigator PI3K / mTOR / radiosensitization / apoptosis / hypoxia / 放射線治療 / 細胞死 / 低酸素 Except Principal Investigator PI3K / mTOR … More / hypoxia / 低酸素 / VEGF / apoptosis / P13K / 細胞死 / gene knockout mouse / transgenic mouse / angiogenesis / 遺伝子発現 / ノックアウトマウス / トランスジェニックマウス / 血管新生 Less

Hypoxia tolerance of cancer cells through suppression of mTOR signaling
- Principal Investigator
  
  INOUE Masahiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka Prefectural Hospital Organization
Radiosensitization of hypoxic cancer cells by activation of mTOR signalingPrincipal Investigator
- Principal Investigator
  
  MUKAI Mutsuko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka Prefectural Hospital Organization
Molecular analysis of compensatory mechanism which tumor cells exert in VEGF deficent/RipTag mouse
- Principal Investigator
  
  INOUE Masahiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Osaka Medical Center for Cancer and Cardiovascular Diseases

All 2006 2005 2004 2003

All Journal Article

[Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006
- Author(s)
  Mukai M., Endo H., Iwasaki T., et al.
- Journal Title
  
  Biochem Biophys Res Commun 346・1
  
  Pages: 74-82
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590284
[Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006
- Author(s)
  Mukai M., Endo H., Iwasaki T., et al.
- Journal Title
  
  Biochem Biophys Res Commun 346.1
  
  Pages: 74-82
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590284
[Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006
- Author(s)
  Mukai M., Endo H., Iwasaki T., et al.
- Journal Title
  
  Biochem Biophys Res Commun 346.1
  
  Pages: 74-82
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591314
[Journal Article] Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis2006
- Author(s)
  Kusama T, Mukai M, Endo H., et al.
- Journal Title
  
  Cancer Science 97.8
  
  Pages: 843-853
- NAID
  10018767306
- Data Source
  KAKENHI-PROJECT-17590284
[Journal Article] Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho2006
- Author(s)
  Kusama T, Mukai M, Tatsuta M., et al.
- Journal Title
  
  International Journal of Oncology 29.1
  
  Pages: 217-23
- Data Source
  KAKENHI-PROJECT-17590284
[Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006
- Author(s)
  Mukai M, Endo H, Iwasaki T., et al.
- Journal Title
  
  Biochem Biophys Res Commun 346.1
  
  Pages: 74-82
- Data Source
  KAKENHI-PROJECT-17590284
[Journal Article] Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis2006
- Author(s)
  Kusama T., Mukai M., Endo H., et al.
- Journal Title
  
  Cancer Science 97.8
  
  Pages: 848-853
- NAID
  10018767306
- Data Source
  KAKENHI-PROJECT-17591314
[Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006
- Author(s)
  Mukai M., Endo H., Iwasaki T., et al.
- Journal Title
  
  Biochem Biophys Res Commun 346・1
  
  Pages: 74-82
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591314
[Journal Article] Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho2006
- Author(s)
  Kusama T., Mukai M., Tatsuta M., et al.
- Journal Title
  
  International Journal of Oncology 29.1
  
  Pages: 217-23
- Data Source
  KAKENHI-PROJECT-17591314
[Journal Article] Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia.2005
- Author(s)
  Hamanaka Y, Mukai M, Shimamura M, et al.
- Journal Title
  
  Biochem Biophys Res Commun 330
  
  Pages: 318-326
- Data Source
  KAKENHI-PROJECT-17590284
[Journal Article] Cross talk between apoptosis and invasion signaling in cancer cells through caspase-3 activation.2005
- Author(s)
  Mukai M, Kusama T, Hamanaka Y, et al.
- Journal Title
  
  Cancer Res 65
  
  Pages: 9121-9125
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591314
[Journal Article] Cross talk between apoptosis and invasion signaling in cancer cells through casupase-3 activation.2005
- Author(s)
  Mukai M, Kusama T, Hamanaka Y, et al.
- Journal Title
  
  Cancer Res 65
  
  Pages: 9121-9125
- Data Source
  KAKENHI-PROJECT-17590284
[Journal Article] Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells.2005
- Author(s)
  Nakamura H, Mukai M, Komatsu K, et al.
- Journal Title
  
  Cancer Lett 220
  
  Pages: 95-99
- Data Source
  KAKENHI-PROJECT-17591314
[Journal Article] Cross talk between apoptosis and invasion signaling in cancer cells through caspase-3 activation.2005
- Author(s)
  Mukai M, Kusama T, Hamanaka Y, et al.
- Journal Title
  
  Cancer Res 65
  
  Pages: 9121-9125
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590284
[Journal Article] Transforming growth factor-betal induces LM07 while enhancing the invasiveness of rat ascites hepatoma cells2005
- Author(s)
  Nakamura, H., Mukai, M., Inoue, M.
- Journal Title
  
  Cancer Lett 220
  
  Pages: 95-99
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590363
[Journal Article] Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia2005
- Author(s)
  Hamanaka, Y., Mukai, M., Inoue, M.
- Journal Title
  
  Biochem Biophys Res Commun 380
  
  Pages: 318-326
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590363
[Journal Article] Cross talk between apoptosis and invasion signaling in cancer cells through casupase-3 activation.2005
- Author(s)
  Mukai M, Kusama T, Hamanaka Y, et al.
- Journal Title
  
  Cancer Res 65
  
  Pages: 9121-9125
- Data Source
  KAKENHI-PROJECT-17591314
[Journal Article] Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia.2005
- Author(s)
  Hamanaka Y, Mukai M, Shimamura M, et al.
- Journal Title
  
  Biochem Biophys Res Commun 330
  
  Pages: 318-326
- Data Source
  KAKENHI-PROJECT-17591314
[Journal Article] Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells.2005
- Author(s)
  Nakamura H, Mukai M, Komatsu K, et al.
- Journal Title
  
  Cancer Lett 220
  
  Pages: 95-99
- Data Source
  KAKENHI-PROJECT-17590284
[Journal Article] Targeting hypoxic cancer cells with a protein prodrug is effective in experimental malignant ascites2004
- Author(s)
  Inoue, M., Mukai, M., Hamanaka, Y.
- Journal Title
  
  Int J Oncol 25
  
  Pages: 713-720
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590363
[Journal Article] Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells2004
- Author(s)
  Nakamura, H., Mukai, M., Inoue, M.
- Journal Title
  
  Cancer Lett 220
  
  Pages: 95-99
- Data Source
  KAKENHI-PROJECT-15590363
[Journal Article] Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor2003
- Author(s)
  Kusama, T., Mukai, M., Inoue, M.et al.
- Journal Title
  
  Clin Exp Metastasis 20
  
  Pages: 561-567
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590363
[Journal Article] Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors2003
- Author(s)
  Kusama, T., Mukai, M., Inoue, M.et al.
- Journal Title
  
  Int J Oncol 23
  
  Pages: 1173-1178
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590363
[Journal Article] Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors2003
- Author(s)
  Kusama, T., Mukai, M., Inoue, M et al.
- Journal Title
  
  Int J Oncol 23
  
  Pages: 1173-1178
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590363
[Journal Article] Cyclic phosphatidic acid inhibits RhoA-mediated autophosphorylation of FAK at Tyr-397 and subsequent tumor-cell invasion2003
- Author(s)
  Mukai, M., Iwasaki, Inoue M et al.
- Journal Title
  
  Int J Oncol 22
  
  Pages: 1247-1256
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590363
[Journal Article] Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor2003
- Author(s)
  Kusama, T., Mukai, M., Inoue, M et al.
- Journal Title
  
  Clin Exp Metastasis 20
  
  Pages: 561-567
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590363
[Journal Article] Cyclic phosphatidic acid inhibits RhoA-mediated autophosphorylation of FAK at Tyr-397 and subsequent tumor-cell invasion2003
- Author(s)
  Mukai, M., Iwasaki, Inoue, M.et al.
- Journal Title
  
  Int J Oncol 22
  
  Pages: 1247-1256
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590363

1. INOUE Masahiro (10342990)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results

MUKAI Mutsuko 向井 睦子

Research Projects

Research Products

Co-Researchers

Hypoxia tolerance of cancer cells through suppression of mTOR signaling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Radiosensitization of hypoxic cancer cells by activation of mTOR signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular analysis of compensatory mechanism which tumor cells exert in VEGF deficent/RipTag mouse

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis2006

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho2006

Author(s)

Journal Title

Data Source

[Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006

Author(s)

Journal Title

Data Source

[Journal Article] Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis2006

Author(s)

Journal Title

NAID

Data Source

[Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho2006

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia.2005

Author(s)

Journal Title

Data Source

[Journal Article] Cross talk between apoptosis and invasion signaling in cancer cells through caspase-3 activation.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Cross talk between apoptosis and invasion signaling in cancer cells through casupase-3 activation.2005

Author(s)

Journal Title

Data Source

[Journal Article] Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells.2005

Author(s)

Journal Title

MUKAI Mutsuko 向井睦子