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MUKAI Mutsuko  向井 睦子

ORCIDConnect your ORCID iD *help
Researcher Number 20342991
Affiliation (based on the past Project Information) *help 2006: Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka Prefectural Hospital Organization, Principal investigator, 研究所, 主任研究員
2006: 地方独立行政法人大阪府立病院機構大阪府立成人病センター, 研究所, 主任研究員
2006: 地方独立行政法人大阪府立病院機構大阪府立成人病センター, 研究所, 研究員
2005: 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 生化学部, 主任研究員
2004: MUKAI,Mutsuko, 主任研究員
2004: 大阪府立成人病センター, 研究所, 主任研究員
2003: 大阪府立成人病センター, 研究所・生化学部, 主任研究員
Review Section/Research Field
Principal Investigator
Radiation science
Except Principal Investigator
Pathological medical chemistry / Experimental pathology
Keywords
Principal Investigator
PI3K / mTOR / radiosensitization / apoptosis / hypoxia / 放射線治療 / 細胞死 / 低酸素
Except Principal Investigator
PI3K / mTOR … More / hypoxia / 低酸素 / VEGF / apoptosis / P13K / 細胞死 / gene knockout mouse / transgenic mouse / angiogenesis / 遺伝子発現 / ノックアウトマウス / トランスジェニックマウス / 血管新生 Less
  • Research Projects

    (3 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (1 People)
  •  Hypoxia tolerance of cancer cells through suppression of mTOR signaling

    • Principal Investigator
      INOUE Masahiro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka Prefectural Hospital Organization
  •  Radiosensitization of hypoxic cancer cells by activation of mTOR signalingPrincipal Investigator

    • Principal Investigator
      MUKAI Mutsuko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka Prefectural Hospital Organization
  •  Molecular analysis of compensatory mechanism which tumor cells exert in VEGF deficent/RipTag mouse

    • Principal Investigator
      INOUE Masahiro
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka Medical Center for Cancer and Cardiovascular Diseases

All 2006 2005 2004 2003

All Journal Article

  • [Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006

    • Author(s)
      Mukai M., Endo H., Iwasaki T., et al.
    • Journal Title

      Biochem Biophys Res Commun 346・1

      Pages: 74-82

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590284
  • [Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006

    • Author(s)
      Mukai M., Endo H., Iwasaki T., et al.
    • Journal Title

      Biochem Biophys Res Commun 346.1

      Pages: 74-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590284
  • [Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006

    • Author(s)
      Mukai M., Endo H., Iwasaki T., et al.
    • Journal Title

      Biochem Biophys Res Commun 346.1

      Pages: 74-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591314
  • [Journal Article] Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis2006

    • Author(s)
      Kusama T, Mukai M, Endo H., et al.
    • Journal Title

      Cancer Science 97.8

      Pages: 843-853

    • NAID

      10018767306

    • Data Source
      KAKENHI-PROJECT-17590284
  • [Journal Article] Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho2006

    • Author(s)
      Kusama T, Mukai M, Tatsuta M., et al.
    • Journal Title

      International Journal of Oncology 29.1

      Pages: 217-23

    • Data Source
      KAKENHI-PROJECT-17590284
  • [Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006

    • Author(s)
      Mukai M, Endo H, Iwasaki T., et al.
    • Journal Title

      Biochem Biophys Res Commun 346.1

      Pages: 74-82

    • Data Source
      KAKENHI-PROJECT-17590284
  • [Journal Article] Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis2006

    • Author(s)
      Kusama T., Mukai M., Endo H., et al.
    • Journal Title

      Cancer Science 97.8

      Pages: 848-853

    • NAID

      10018767306

    • Data Source
      KAKENHI-PROJECT-17591314
  • [Journal Article] RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells2006

    • Author(s)
      Mukai M., Endo H., Iwasaki T., et al.
    • Journal Title

      Biochem Biophys Res Commun 346・1

      Pages: 74-82

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591314
  • [Journal Article] Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho2006

    • Author(s)
      Kusama T., Mukai M., Tatsuta M., et al.
    • Journal Title

      International Journal of Oncology 29.1

      Pages: 217-23

    • Data Source
      KAKENHI-PROJECT-17591314
  • [Journal Article] Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia.2005

    • Author(s)
      Hamanaka Y, Mukai M, Shimamura M, et al.
    • Journal Title

      Biochem Biophys Res Commun 330

      Pages: 318-326

    • Data Source
      KAKENHI-PROJECT-17590284
  • [Journal Article] Cross talk between apoptosis and invasion signaling in cancer cells through caspase-3 activation.2005

    • Author(s)
      Mukai M, Kusama T, Hamanaka Y, et al.
    • Journal Title

      Cancer Res 65

      Pages: 9121-9125

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591314
  • [Journal Article] Cross talk between apoptosis and invasion signaling in cancer cells through casupase-3 activation.2005

    • Author(s)
      Mukai M, Kusama T, Hamanaka Y, et al.
    • Journal Title

      Cancer Res 65

      Pages: 9121-9125

    • Data Source
      KAKENHI-PROJECT-17590284
  • [Journal Article] Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells.2005

    • Author(s)
      Nakamura H, Mukai M, Komatsu K, et al.
    • Journal Title

      Cancer Lett 220

      Pages: 95-99

    • Data Source
      KAKENHI-PROJECT-17591314
  • [Journal Article] Cross talk between apoptosis and invasion signaling in cancer cells through caspase-3 activation.2005

    • Author(s)
      Mukai M, Kusama T, Hamanaka Y, et al.
    • Journal Title

      Cancer Res 65

      Pages: 9121-9125

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590284
  • [Journal Article] Transforming growth factor-betal induces LM07 while enhancing the invasiveness of rat ascites hepatoma cells2005

    • Author(s)
      Nakamura, H., Mukai, M., Inoue, M.
    • Journal Title

      Cancer Lett 220

      Pages: 95-99

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590363
  • [Journal Article] Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia2005

    • Author(s)
      Hamanaka, Y., Mukai, M., Inoue, M.
    • Journal Title

      Biochem Biophys Res Commun 380

      Pages: 318-326

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590363
  • [Journal Article] Cross talk between apoptosis and invasion signaling in cancer cells through casupase-3 activation.2005

    • Author(s)
      Mukai M, Kusama T, Hamanaka Y, et al.
    • Journal Title

      Cancer Res 65

      Pages: 9121-9125

    • Data Source
      KAKENHI-PROJECT-17591314
  • [Journal Article] Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia.2005

    • Author(s)
      Hamanaka Y, Mukai M, Shimamura M, et al.
    • Journal Title

      Biochem Biophys Res Commun 330

      Pages: 318-326

    • Data Source
      KAKENHI-PROJECT-17591314
  • [Journal Article] Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells.2005

    • Author(s)
      Nakamura H, Mukai M, Komatsu K, et al.
    • Journal Title

      Cancer Lett 220

      Pages: 95-99

    • Data Source
      KAKENHI-PROJECT-17590284
  • [Journal Article] Targeting hypoxic cancer cells with a protein prodrug is effective in experimental malignant ascites2004

    • Author(s)
      Inoue, M., Mukai, M., Hamanaka, Y.
    • Journal Title

      Int J Oncol 25

      Pages: 713-720

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590363
  • [Journal Article] Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells2004

    • Author(s)
      Nakamura, H., Mukai, M., Inoue, M.
    • Journal Title

      Cancer Lett 220

      Pages: 95-99

    • Data Source
      KAKENHI-PROJECT-15590363
  • [Journal Article] Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor2003

    • Author(s)
      Kusama, T., Mukai, M., Inoue, M.et al.
    • Journal Title

      Clin Exp Metastasis 20

      Pages: 561-567

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590363
  • [Journal Article] Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors2003

    • Author(s)
      Kusama, T., Mukai, M., Inoue, M.et al.
    • Journal Title

      Int J Oncol 23

      Pages: 1173-1178

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590363
  • [Journal Article] Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors2003

    • Author(s)
      Kusama, T., Mukai, M., Inoue, M et al.
    • Journal Title

      Int J Oncol 23

      Pages: 1173-1178

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590363
  • [Journal Article] Cyclic phosphatidic acid inhibits RhoA-mediated autophosphorylation of FAK at Tyr-397 and subsequent tumor-cell invasion2003

    • Author(s)
      Mukai, M., Iwasaki, Inoue M et al.
    • Journal Title

      Int J Oncol 22

      Pages: 1247-1256

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590363
  • [Journal Article] Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor2003

    • Author(s)
      Kusama, T., Mukai, M., Inoue, M et al.
    • Journal Title

      Clin Exp Metastasis 20

      Pages: 561-567

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590363
  • [Journal Article] Cyclic phosphatidic acid inhibits RhoA-mediated autophosphorylation of FAK at Tyr-397 and subsequent tumor-cell invasion2003

    • Author(s)
      Mukai, M., Iwasaki, Inoue, M.et al.
    • Journal Title

      Int J Oncol 22

      Pages: 1247-1256

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590363
  • 1.  INOUE Masahiro (10342990)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results

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