Hori Tetsuya 堀哲哉

… Alternative Names

堀哲哉ホリテツヤ

HORI Tetsuya 堀哲哉

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Researcher Number	20344054
Other IDs	https://orcid.org/0000-0002-4025-3534
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 専任研究員
Affiliation (based on the past Project Information) *help	2019 – 2023: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 専任研究員 2011 – 2012: 独立行政法人理化学研究所, 宮野構造生物物理研究室, 専任研究員 2008: The Institute of Physical and Chemical Research, 宮野構造生物物理研究室, 研究員 2007: The Institute of Physical and Chemical Research, 宮野構造生物物理研究室, 研究員
Review Section/Research Field	Principal Investigator Structural biochemistry / Basic Section 38030:Applied biochemistry-related / Basic Section 43020:Structural biochemistry-related
Keywords	Principal Investigator GPCR / 結晶化 / 精製 / 大量発現 / Gタンパク質共役型受容体 / 殺虫剤、殺ダニ剤 / オクトパミン受容体 / 合理的設計法 / 合理的設計 / ベンザミジン … More / ベンズアミジン / インバースアゴニスト / ベンズアミジン派生物 / 逆作動薬 / 大量調製 / 熱安定化 / モノクロ抗体作成 / 安定化 / ロイコトリエンB4受容体 / モノクローナル抗体 / 安定化変異体 / メタノール資化酵母 / G-タンパク質共役型受容体 / ロイコトリエンB_4 受容体 / 可溶化 / 発現条件最適化 / リガンド結合活性 / 変異体 / 翻訳後修飾 / 酵母 / ロイコトリエンB_4 Less

Research Projects
(4 results)
Research Products
(14 results)

ダニ・アリ由来オクトパミン受容体群の機能解析・結晶構造解析Principal Investigator
- Principal Investigator
  
  堀哲哉
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Toward rational design of inverse agonist of GPCRsPrincipal Investigator
- Principal Investigator
  
  Hori Tetsuya
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Crystallization of stabilized leukotriene B4 receptor mutant and monoclonal antibody complex.Principal Investigator
- Principal Investigator
  
  HORI Tetsuya
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
Expression, purification and crystallization of leukotriene B4 receptor in yeast expression systemPrincipal Investigator
- Principal Investigator
  
  HORI Tetsuya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The Institute of Physical and Chemical Research

All 2022 2021 2020 2011 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] Ions as GPCR allosteric modulators2022
- Author(s)
  Tetsuya Hori and Shigeyuki Yokoyama
- Total Pages
  18
- Publisher
  Academic press
- ISBN
  9780128197714
- Data Source
  KAKENHI-PROJECT-19K06534
[Journal Article] Crystallization of Leukotriene B<sub>4</sub> Receptor2022
- Author(s)
  堀哲哉, 横山茂之
- Journal Title
  
  SPring-8/SACLA Research Report
  
  Volume: 10 Issue: 3 Pages: 286-289
- DOI
  10.18957/rr.10.3.286
- ISSN
  2187-6886
- Year and Date
  2022-06-30
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06534
[Journal Article] 最近のGPCR創薬 -GPCRの構造ゲノム創薬の発展とさらなる創薬研究にむけて2021
- Author(s)
  中村元直, 堀　哲哉, 宮野雅司
- Journal Title
  
  脳神経内科
  
  Volume: 94 Pages: 496-506
- Data Source
  KAKENHI-PROJECT-19K06534
[Journal Article] Membrane protein crystallography for structure-based drug design2009
- Author(s)
  Miyano, M., Ago, H., and Hori, T.
- Journal Title
  
  Medchem News 19
  
  Pages: 20-31
- Data Source
  KAKENHI-PROJECT-19770095
[Journal Article] Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region.2008
- Author(s)
  Tatsuro Shimamura, Kenji Hiraki, Naoko Takahashi, Tetsuya Hori, Hideo Ago, Katsuyoshi Masuda, Koji Takio, Masaji Ishiguro and Masashi Miyano
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 17753-17756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770095
[Journal Article] 脂質メディエータ合成酵素の構造と機能 ; 最近の進展2008
- Author(s)
  吾郷日出夫、堀哲哉、宮野雅司
- Journal Title
  
  分子心血管病 9
  
  Pages: 63-70
- Data Source
  KAKENHI-PROJECT-19770095
[Journal Article] Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum
- Author(s)
  asuda D, Okuno T, Yokomizo T, Hori T, Hirota N, Hashidate T, Miyano M, Shimizu T, Nakamura M.
- Journal Title
  
  FASEB J (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770095
[Presentation] ナトリウムイオンによるGPCRの活性抑制機構を模倣する逆作動薬の合理的設計に向けて2020
- Author(s)
  堀　哲哉
- Organizer
  日本生化学会年会
- Data Source
  KAKENHI-PROJECT-19K06534
[Presentation] Thermostabilization and generation of monoclonal antibody to leukotriene B_4 receptor (BLT1) for crystallization,2011
- Author(s)
  Hori T., Sugahara M., Nakamura M., Yokomizo T., Shimizu T., and Miyano M.
- Organizer
  GPCR Workshop 2011
- Place of Presentation
  マウイ
- Year and Date
  2011-12-05
- Data Source
  KAKENHI-PROJECT-23770133
[Presentation] 結晶化のためのロイコトリエンB4受容体(BLT1)の熱安定化と抗BLT1モノクローナル抗体の作製2011
- Author(s)
  堀　哲哉
- Organizer
  日本生化学会年会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-23770133
[Presentation] Thermostabilization and generation of monoclonal antibody to leukotriene B4 receptor (BLT1) for crystallization2011
- Author(s)
  堀　哲哉
- Organizer
  GPCR workshop 2011
- Place of Presentation
  マウイ、ハワイ
- Data Source
  KAKENHI-PROJECT-23770133
[Presentation] 結晶化のためのロイコトリエンB_4受容体(BLT1)の熱安定化と抗BLT1モノクローナル抗体の作製2011
- Author(s)
  堀哲哉、菅原光明、中村元直、横溝岳彦、清水孝雄、宮野雅司
- Organizer
  第84回日本生化学会大会(BMB2011)
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23770133
[Presentation] Leukotriene B_4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex structure with anticonfiguration of indomethacin2007
- Author(s)
  堀哲哉, 石嶋潤, 横溝岳彦, 吾郷日出夫, 清水孝雄, 宮野雅司
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会(BMB2007)
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19770095
[Presentation] Leukotriene B_4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex structure with anticonfiguration of indomethacin2007
- Author(s)
  堀哲哉
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会 (BMB2007)
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19770095

Hori Tetsuya 堀 哲哉

堀 哲哉 ホリ テツヤ

HORI Tetsuya 堀 哲哉

Research Projects

Research Products

ダニ・アリ由来オクトパミン受容体群の機能解析・結晶構造解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Toward rational design of inverse agonist of GPCRsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Crystallization of stabilized leukotriene B4 receptor mutant and monoclonal antibody complex.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression, purification and crystallization of leukotriene B4 receptor in yeast expression systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Ions as GPCR allosteric modulators2022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Crystallization of Leukotriene B<sub>4</sub> Receptor2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] 最近のGPCR創薬 -GPCRの構造ゲノム創薬 の発展とさらなる創薬研究にむけて2021

Author(s)

Journal Title

Data Source

[Journal Article] Membrane protein crystallography for structure-based drug design2009

Author(s)

Journal Title

Data Source

[Journal Article] Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region.2008

Author(s)

Journal Title

Data Source

[Journal Article] 脂質メディエータ合成酵素の構造と機能 ; 最近の進展2008

Author(s)

Journal Title

Data Source

[Journal Article] Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum

Author(s)

Journal Title

Data Source

[Presentation] ナトリウムイオンによるGPCRの活性抑制機構を模倣する逆作動薬の合理的設計に向けて2020

Author(s)

Organizer

Data Source

[Presentation] Thermostabilization and generation of monoclonal antibody to leukotriene B_4 receptor (BLT1) for crystallization,2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 結晶化のためのロイコトリエンB4受容体(BLT1)の熱安定化と抗BLT1モノクローナル抗体の作製2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Thermostabilization and generation of monoclonal antibody to leukotriene B4 receptor (BLT1) for crystallization2011

Author(s)

Hori Tetsuya 堀哲哉

堀哲哉ホリテツヤ

HORI Tetsuya 堀哲哉

[Journal Article] 最近のGPCR創薬 -GPCRの構造ゲノム創薬の発展とさらなる創薬研究にむけて2021