Konishi Hiroyuki 小西裕之

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KONISHI Hiroyuki 小西裕之

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Researcher Number	20344335
Other IDs
Affiliation (Current)	2025: 愛知医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 愛知医科大学, 医学部, 教授 2013 – 2020: 愛知医科大学, 医学部, 教授 2010 – 2012: 愛知医科大学, 医学部, 准教授 2003 – 2004: 愛知県がんセンター, 分子腫瘍学部, 主任研究員 2002: 愛知がんセンター, 分子腫瘍学部, 主任研究員
Review Section/Research Field	Principal Investigator Basic Section 43050:Genome biology-related / Basic Section 43060:System genome science-related / System genome science / Medical genome science / Carcinogenesis Except Principal Investigator Biological Sciences / Pathological medical chemistry / Gastroenterology
Keywords	Principal Investigator ゲノム編集 / Cas9 / CRISPR / tandem paired nicking / ノックイン / nickase / CRISPR-Cas9 / Cas9 nickase / ゲノム生物工学 / CRISPR/Cas9 … More / ニック / 2A / 遺伝子改変 / アデノ随伴ウイルスベクター / ヒト細胞遺伝子改変法 / ヒト細胞遺伝子改変 / ゲノム不安定性 / ハプロ不全 / BRCA1 … More Except Principal Investigator 肺癌 / checkpoint / metastasis / bioinformatics / microarray / expression profiling / lung cancer / molecular oncology / 分子疫学 / 癌抑制遺伝子 / 染色体不安定性 / がん遺伝子 / がん抑制遺伝子 / 網羅的発現解析 / 転移 / バイオインフォマティクス / 網羅的遺伝子発現解析 / チェックポイント / 浸潤・転移 / バイオインフオマティクス / マイクロアレー / 発現プロファイリング / 分子腫瘍医学 / ゲノム編集 / 気道上皮 / 遺伝子改変 / 気管支上皮 / 気管支上皮細胞株 / 変異ノックイン / KRAS / AAV / 肝細胞 / 内在性遺伝子破壊 / knock-out / △N40p53 / 遺伝子ターゲッティング / TP53 / G1/S / p21 / delta-N40p53 / p53 / 細胞周期 / 肝癌 Less

高性能な改良型CRISPR/Cas9ゲノム編集システムの確立と応用展開Principal Investigator
- Principal Investigator
  
  小西裕之
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Aichi Medical University
臨床応用を目指す高効率・高精度なCRISPRノックイン法の確立Principal Investigator
- Principal Investigator
  
  小西裕之
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Aichi Medical University
Genome editing without DNA double-strand breaks mediated by CRISPR-Cas9 nickasesPrincipal Investigator
- Principal Investigator
  
  Konishi Hiroyuki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  System genome science
- Research Institution
  Aichi Medical University
Defining the KRAS signaling cascade using a genome-edited human bronchial epithelial cell line
- Principal Investigator
  
  Sivasundaram Karnan
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Aichi Medical University
Development of a highly specific genome editing technology for human cells using adeno-associated viral vectorPrincipal Investigator
- Principal Investigator
  
  Hiroyuki Konishi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical genome science
- Research Institution
  Aichi Medical University
The analysis of checkpoint mechanism of cell cycle in liver cancer cells
- Principal Investigator
  
  NAKAO Haruhisa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University
Characterization of human BRCA1 heterozygous knockout cell lines created by somatic cell gene targetingPrincipal Investigator
- Principal Investigator
  
  KONISHI Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Carcinogenesis
- Research Institution
  Aichi Medical University
Multifaceted analysis of molecular pathogenesis of human lung cancers
- Principal Investigator
  
  TAKAHASHI Takashi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
  Aichi Cancer Center Research Institute

[Journal Article] CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia2021
- Author(s)
  Karnan S, Hanamura I, Ota A, Takasugi S, Nakamura A, Takahashi M, Uchino K, Murakami S, Wahiduzzaman M, Vu LQ, Rahman ML, Hasan MN, Hyodo T, Konishi H, Tsuzuki S, Yoshikawa K, Suzuki S, Ueda R, Ejiri M, Hosokawa Y, and Takami A
- Journal Title
  
  Cell Death Discov
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-20K06613
[Journal Article] CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia2021
- Author(s)
  1.Karnan S, Hanamura I, Ota A, Takasugi S, Nakamura A, Takahashi M, Uchino K, Murakami S, Wahiduzzaman M, Vu LQ, Rahman ML, Hasan MN, Hyodo T, Konishi H, Tsuzuki S, Yoshikawa K, Suzuki S, Ueda R, Ejiri M, Hosokawa Y, and Takami A
- Journal Title
  
  Cell Death Discovery
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07263
[Journal Article] Bi-allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells2020
- Author(s)
  Kanasugi J, Hanamura I, Ota A, Karnan S, Vu LQ, Mizuno S, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Takami A
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 5 Pages: 999-999
- DOI
  10.1111/cas.14386
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-17K07263
[Journal Article] Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia2020
- Author(s)
  Shinobu Tsuzuki, Takahiko Yasuda, Shinya Kojima, Masahito Kawazu, Koshi Akahane, Takeshi Inukai, Masue Imaizumi, Takanobu Morishita, Masashi Sanada,　Hideki Muramatsu, Yoshiyuki Takahashi, Yasushi Miyazaki, Itaru Matsumura, Hitoshi Kiyoi, Yoshitaka Hosokawa, Hiroyuki Mano, Fumihiko Hayakawa
- Journal Title
  
  Blood Cancer Discovery
  
  Volume: 1 Issue: 1 Pages: 82-95
- DOI
  10.1158/2643-3230.bcd-19-0080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02645, KAKENHI-PROJECT-20K06613, KAKENHI-PROJECT-17K07263
[Journal Article] Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells2020
- Author(s)
  Ota Akinobu、Hanamura Ichiro、Karnan Sivasundaram、Inaguma Shingo、Takei Norio、Lam Vu Quang、Mizuno Shohei、Kanasugi Jo、Wahiduzzaman Md、Rahman Md Lutfur、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Ikeda Hiroshi、Takami Akiyoshi、Hosokawa Yoshitaka
- Journal Title
  
  Journal of Interferon & Cytokine Research
  
  Volume: 40 Issue: 8 Pages: 389-405
- DOI
  10.1089/jir.2020.0111
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K07060, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-20K06613, KAKENHI-PROJECT-17K07263
[Journal Article] Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma2020
- Author(s)
  Kondo Sayuri、Ota Akinobu、Ono Takayuki、Karnan Sivasundaram、Wahiduzzaman Md、Hyodo Toshinori、Lutfur Rahman Md、Ito Kunihiro、Furuhashi Akifumi、Hayashi Tomio、Konishi Hiroyuki、Tsuzuki Shinobu、Hosokawa Yoshitaka、Kazaoka Yoshiaki
- Journal Title
  
  Cancer Medicine
  
  Volume: 9 Issue: 8 Pages: 2904-2917
- DOI
  10.1002/cam4.2931
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07263
[Journal Article] Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma2020
- Author(s)
  KarnanS, Ota A, Murakami H, Rahman ML, Hasan 　MN, Wahiduzzaman MD, Hanamura I, Vu LQ, Inoko A, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y.
- Journal Title
  
  Cell Death Discovery
  
  Volume: 18 Issue: 1 Pages: 127-139
- DOI
  10.1038/s41420-020-00364-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08668, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K07031, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-20K06613, KAKENHI-PROJECT-17K07263
[Journal Article] Tandem paired nicking promotes precise genome editing with scarce interference by p532019
- Author(s)
  Hyodo T, Rahman ML, Karnan S, Ito T, Toyoda A, Ota A, Wahiduzzaman M, Tsuzuki S, Okada Y, Hosokawa Y, Konishi H.
- Journal Title
  
  Cell Rep.
  
  Volume: 30 Issue: 4 Pages: 1195-1207
- DOI
  10.1016/j.celrep.2019.12.064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19H03576, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-18K15470, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-19J40240, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07263
[Journal Article] Establishment and characterization of CRISPR/Cas9-mediated NF2(-/-) human mesothelial cell line: Molecular insight into fibroblast growth factor receptor 2 in malignant pleural mesothelioma2019
- Author(s)
  Wahiduzzaman Md、Karnan Sivasundaram、Ota Akinobu、Hanamura Ichiro、Murakami Hideki、Inoko Akihito、Rahman Md Lutfur、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Hosokawa Yoshitaka
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 1 Pages: 180-193
- DOI
  10.1111/cas.13871
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07263
[Journal Article] Inhibition of NADPH oxidase 2 induces apoptosis in osteosarcoma: The role of reactive oxygen species in cell proliferation2018
- Author(s)
  Kitamoto Kazumasa、Miura Yuji、Karnan Sivasundaram、Ota Akinobu、Konishi Hiroyuki、Hosokawa Yoshitaka、Sato Keiji
- Journal Title
  
  Oncology Letters
  
  Volume: 15 Pages: 7955-7962
- DOI
  10.3892/ol.2018.8291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07263
[Journal Article] Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo2018
- Author(s)
  Wahiduzzaman Md、Ota Akinobu、Karnan Sivasundaram、Hanamura Ichiro、Mizuno Shohei、Kanasugi Jo、Rahman Md Lutfur、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Takami Akiyoshi、Hosokawa Yoshitaka
- Journal Title
  
  Cancer Letters
  
  Volume: 433 Pages: 117-130
- DOI
  10.1016/j.canlet.2018.06.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-17K07263
[Journal Article] Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells.2017
- Author(s)
  Yamaji M, Ota A, Wahiduzzaman M, Karnan S, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Hanyuda M.
- Journal Title
  
  Cancer Med
  
  Volume: 6 Issue: 11 Pages: 2646-2659
- DOI
  10.1002/cam4.1179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07263
[Journal Article] Delta40p53 suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells2017
- Author(s)
  Ota A, Nakao H, Sawada Y, Karnan S, Wahiduzzaman M, Inoue T, Kobayashi Y, Yamamoto T, Ishii N, Ohashi T, Nakade Y, Sato K, Itoh K, Konishi H, Hosokawa Y, Yoneda M
- Journal Title
  
  J Cell Sci
  
  Volume: 130 Issue: 3 Pages: 614-625
- DOI
  10.1242/jcs.190736
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-15K19561, KAKENHI-PROJECT-16K09381, KAKENHI-PROJECT-17K09442, KAKENHI-PROJECT-17K07263
[Journal Article] Inhibition of Nox1 induces apoptosis by attenuating the AKT signaling pathway in oral squamous cell carcinoma cell lines2016
- Author(s)
  Ito K, Ota A, Ono T, Nakaoka T, Wahiduzzaman M, Karnan S, Konishi H, Furuhashi A, Hayashi T, Yamada Y, Hosokawa Y, and Kazaoka Y
- Journal Title
  
  Oncol Rep
  
  Volume: 36 Issue: 5 Pages: 2991-2998
- DOI
  10.3892/or.2016.5068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-15K19561
[Journal Article] Efficient AAV-mediated gene targeting using 2A-based promoter-trap system2016
- Author(s)
  Karnan S, Ota A, Konishi Y, Wahiduzzaman M, Tsuzuki S, Hosokawa Y, and Konishi H
- Journal Title
  
  Bio-Protoc
  
  Volume: 6 Issue: 24
- DOI
  10.21769/bioprotoc.2058
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460395
[Journal Article] Improved methods of AAV-mediated gene targeting for human cell lines using ribosome-skipping 2A peptide2016
- Author(s)
  Karnan S, Ota A, Konishi Y, Wahiduzzaman M, Hosokawa Y, and Konishi H
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 44 Issue: 6 Pages: e54-e54
- DOI
  10.1093/nar/gkv1338
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107, KAKENHI-PROJECT-15K19561
[Journal Article] Inhibition of NADPH oxidase 4 induces apoptosis in malignant mesothelioma: Role of reactive oxygen species2015
- Author(s)
  Tanaka M, Miura Y, Numanami H, Karnan S, Ota A, Konishi H, Hosokawa Y, and Hanyuda M
- Journal Title
  
  Oncology Reports
  
  Volume: 34 Issue: 4 Pages: 1726-1732
- DOI
  10.3892/or.2015.4155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] High-resolution 400K oligonucleotide array comparative genomic hybridization analysis of neurofibromatosis type 1-associated cutaneous neurofibromas2015
- Author(s)
  Asai A, Karnan S, Ota A, Takahashi M, Damdindorj L, Konishi Y, Hossain E, Konishi H, Nagata A, Yokoo K, Hosokawa Y
- Journal Title
  
  Gene
  
  Volume: 558 Pages: 220-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395
[Journal Article] Plumbagin suppresses tumor cell growth in oral squamous cell carcinoma cell lines2015
- Author(s)
  Ono T, Ota A, Ito K, Nakaoka T, Karnan S, Konishi H, Furuhashi A, Hayashi T, Yamada Y, Hosokawa Y, Kazaoka Y
- Journal Title
  
  Oral Dis
  
  Volume: - Issue: 4 Pages: 501-511
- DOI
  10.1111/odi.12310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] High-resolution 400K oligonucleotide array comparative genomic hybridization analysis of neurofibromatosis type 1-associated cutaneous neurofibromas2015
- Author(s)
  Asai A, Karnan S, Ota A, Takahashi M, Damdindorj L, Konishi Y, Hossain E, Konishi H, Nagata A, Yokoo K, Hosokawa Y
- Journal Title
  
  Gene
  
  Volume: 558 Pages: 220-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640107
[Journal Article] Lipopolysaccharide augments the uptake of oxidized LDL by up-regulating lectin-like oxidized LDL receptor-1 in macrophages2015
- Author(s)
  Hossain E, Ota A, Karnan S, Takahashi M, Mannan SB, Konishi H, Hosokawa Y
- Journal Title
  
  Mol Cell Biochem
  
  Volume: 400 Issue: 1-2 Pages: 29-40
- DOI
  10.1007/s11010-014-2259-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] Combined arsenic trioxide-cisplatin treatment enhances apoptosis in oral squamous cell carcinoma cells.2014
- Author(s)
  Nakaoka T, Ota A, Ono T, Karnan S, Konishi H, Furuhashi A, Ohmura Y, Yamada Y, Hosokawa Y, and Kazaoka Y.
- Journal Title
  
  Cell Oncol
  
  Volume: 37 Issue: 2 Pages: 119-129
- DOI
  10.1007/s13402-014-0167-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] A comparative analysis of constitutive promoters located in adeno-associated viral vectors2014
- Author(s)
  Damdindorj L, Karnan S, Ota A, Hossain E, Konishi Y, Hosokawa Y, Konishi H
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 8 Pages: e106472-e106472
- DOI
  10.1371/journal.pone.0106472
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] KRAS変異がんの治療法 --- 複数の分子標的薬剤を併用する ---2013
- Author(s)
  小西裕之
- Journal Title
  
  実験医学
  
  Volume: 31 Pages: 538-539
- Data Source
  KAKENHI-PROJECT-25640107
[Journal Article] Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation.2013
- Author(s)
  Wang GM, Wong HY, Konishi H, Blair BG, Abukhdeir AM, Gustin JP, Rosen DM, Denmeade S, Rasheed Z, Matsui W, Garay JP, Mohseni M, Higgins MJ, Cidado J, Jelovac D, Croessmann S, Cochran R, Karnan S, Konishi Y, Ota A, Hosokawa Y, Argani P, Lauring J, and Park BH.
- Journal Title
  
  Cancer Res
  
  Volume: 73 Issue: 11 Pages: 3248-3261
- DOI
  10.1158/0008-5472.can-12-1578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] KRAS 変異がんの治療法 --- 複数の分子標的薬剤を併用する ---2013
- Author(s)
  小西裕之
- Journal Title
  
  実験医学
  
  Volume: 31 Pages: 538-539
- URL
  https://www.yodosha.co.jp/jikkenigaku/nhpd/9784758100939/c3.html
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] Arsenic trioxide prevents nitric oxide production in LPS-stimulated RAW 264.7 by inhibiting a TRIF-dependent pathway.2013
- Author(s)
  Takahashi M, Ota A, Karnan S, Ekhtear H, Konishi Y, Damdindorj L, Konishi H, Yokochi T, Nitta M, Hosokawa Y.
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Issue: 2 Pages: 165-70
- DOI
  10.1111/cas.12053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] Arsenic upregulates the expression of angiotensin II Type I receptor in mouse aortic endothelial cells.2013
- Author(s)
  Hossain E, Ota A, Takahashi M, Karnan S, Damdindorj L, Konishi Y, Konishi H, and Hosokawa Y.
- Journal Title
  
  Toxicol Lett
  
  Volume: 220 Issue: 1 Pages: 70-75
- DOI
  10.1016/j.toxlet.2013.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] Arsenic augments the uptake of oxidized LDL by upregulating the expression of lectin-like oxidized LDL receptor in mouse aortic endothelial cells.2013
- Author(s)
  Hossain E, Ota A, Karnan S, Damdindorj L, Takahashi M, Konishi Y, Konishi H, and Hosokawa Y.
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 273 Issue: 3 Pages: 651-658
- DOI
  10.1016/j.taap.2013.10.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] KRAS変異がんの治療法 -- 複数の分子標的薬剤を併用する --2013
- Author(s)
  小西裕之
- Journal Title
  
  実験医学
  
  Volume: 31 Pages: 538-539
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] Assessment of the long-term transcriptional activity of a 550-bp-long human ss-actin promoter region.2012
- Author(s)
  Damdindorj L, Karnan S, Ota A, Takahashi M, Konishi Y, Hossain E, Hosokawa Y, Konishi H.
- Journal Title
  
  Plasmid
  
  Volume: 68 Issue: 3 Pages: 195-200
- DOI
  10.1016/j.plasmid.2012.07.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] The growth response to androgen receptor signaling in ERalpha-negative human breast cells is dependent on p21 and mediated by MAPK activation.2012
- Author(s)
  Garay JP, Karakas B, Abukhdeir AM, Cosgrove DP, Gustin JP, Higgins MJ, Konishi H, Konishi Y, Lauring J, Mohseni M, Wang GM, Jelovac D, Weeraratna A, Sherman Baust CA, Morin PJ, Toubaji A, Meeker A, De Marzo AM, Lewis G, Subhawong A, Argani P, Park BH.
- Journal Title
  
  Breast Cancer Res
  
  Volume: 14 Issue: 1
- DOI
  10.1186/bcr3112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] A system for the measurement of gene targeting efficiency in human cell lines using an antibiotic resistance-GFP fusion gene.2012
- Author(s)
  Konishi Y, Karnan S, Takahashi M, Ota A, Damdindorj L, Hosokawa Y, Konishi H.
- Journal Title
  
  BioTechniques
  
  Volume: 53 Issue: 3 Pages: 141-152
- DOI
  10.2144/0000113911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] Simple monitoring of gene targeting efficiency in human somatic cell lines using the PIGA gene.2012
- Author(s)
  Karnan S, Konishi Y, Ota A, Takahashi M, Damdindorj L, Hosokawa Y, Konishi H.
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 10 Pages: e47389-e47389
- DOI
  10.1371/journal.pone.0047389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.2011
- Author(s)
  Konishi H, Mohseni M, Tamaki A, Garay JP, Croessmann S, Karnan S, Ota A, Wong HY, Konishi Y, Karakas B, Tahir K, Abukhdeir AM, Gustin JP, Cidado J, Wang GM, Cosgrove D, Cochran R, Jelovac D, Higgins MJ, Arena S, Hawkins L, Lauring J, Gross AL, Heaphy CM, Hosokawa Y, Gabrielson E, Meeker AK, Visvanathan K, Argani P, Bachman KE, Park BH.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 108 Issue: 43 Pages: 17773-8
- DOI
  10.1073/pnas.1110969108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999, KAKENHI-PROJECT-22700888
[Journal Article] PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells.2011
- Author(s)
  Higgins MJ, Beaver JA, Wong HY, Gustin JP, Lauring JD, Garay JP, Konishi H, Mohseni M, Wang GM, Cidado J, Jelovac D, Cosgrove DP, Tamaki A, Abukhdeir AM, Park BH.
- Journal Title
  
  Cancer Biol Ther
  
  Volume: 11 Issue: 3 Pages: 358-67
- DOI
  10.4161/cbt.11.3.14227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] Novel Metastasis-Related Gene CIM Functions in the Regulation of Multiple Cellular Stress-Response Pathways.2010
- Author(s)
  Yanagisawa K, Konishi H, Arima C, Tomida S, Takeuchi T, Shimada Y, Yatabe Y, Mitsudomi T, Osada H, Takahashi T.
- Journal Title
  
  Cancer Res
  
  Volume: 70 Issue: 23 Pages: 9949-58
- DOI
  10.1158/0008-5472.can-10-1055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations.2010
- Author(s)
  Lauring J, Cosgrove DP, Fontana S, Gustin JP, Konishi H, Abukhdeir AM, Garay JP, Mohseni M, Wang GM, Higgins M, Gorkin D, Reis M, Vogelstein B, Polyak K, Cowherd M, Buckhaults PJ, Park BH.
- Journal Title
  
  Oncogene
  
  Volume: 29 Issue: 16 Pages: 2337-45
- DOI
  10.1038/onc.2009.516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival.2004
- Author(s)
  Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada T, Harano T, Yatabe Y, Nagino M, Nimura Y, Mitsudomi T, Takahashi T.
- Journal Title
  
  Cancer Res. 64
  
  Pages: 3753-3760
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213163
[Journal Article] Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers.2002
- Author(s)
  Mizuno K, Osada H, Konishi H, Tatematsu Y, Fujii Y, Takahashi T.
- Journal Title
  
  Oncogene 21
  
  Pages: 2328-2333
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213163
[Journal Article] Identification of frequent G2 checkpoint impairment and a homozygous deletion of 14-3-3ε at 17p13.3 in small cell lung cancers2002
- Author(s)
  Konishi, H., et al.
- Journal Title
  
  Cancer Res. 62
  
  Pages: 271-276
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12213163
[Journal Article] Identification of frequent G2 checkpoint impairment and a homozygous deletion of 14-3-3e at 17pl3.3 in small cell lung cancers.2002
- Author(s)
  Konishi H, Nakagawa T, Harano T, Mizuno K, Saito H, Masuda A, Matsuda H, Osada H, Takahashi T.
- Journal Title
  
  Cancer Res. 62
  
  Pages: 271-276
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213163
[Journal Article] Persistent increase in chromosome insta.bility in lung cancer : possible indirect involvement of p53 inactivation.2001
- Author(s)
  Haruki N, Harano T, Masuda A, Kiyono T, Tatematsu Y, Shimizu S, Mitsudomi T, Konishi H, Osada H, Fujii Y, Takahashi T.
- Journal Title
  
  Am.J.Pathol. 159
  
  Pages: 1345-1352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213163
[Presentation] Tandem paired nicking using Cas9 nickases permits targeted knock-in without significant inhibition by p532019
- Author(s)
  Toshinori Hyodo, Md Lutfur Rahman, Atsushi Toyoda, Sivasundaram Karnan, Akinobu Ota, Shinobu Tuzuki, Yoshitaka Hosokawa, 〇Hiroyuki Konishi
- Organizer
  Frontiers in Genome Engineering 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] CRISPR/Cas9 nickaseによるサイレント変異不要のノックイン2019
- Author(s)
  兵頭寿典, Md Lutfur Rahman, 豊田敦, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝, 〇小西裕之
- Organizer
  日本ゲノム編集学会第4回大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] CRISPR/Cas9を用いたNF2及びCDKN2Aノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析2019
- Author(s)
  Sivasundaram Karnan, 太田明伸, 兵頭寿典, 小西裕之, 都築忍, 細川好孝
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] DNA二重鎖切断を介さない変異ノックイン法2019
- Author(s)
  兵頭寿典, Md Lutfur Rahman, 豊田敦, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝, 〇小西裕之
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] CRISPR/Cas9 nickaseによるサイレント変異不要のノックイン2019
- Author(s)
  兵頭寿典, Md Lutfur Rahman, 豊田敦, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝, 小西裕之
- Organizer
  日本ゲノム編集学会第4回大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] Experimental conditions permitting efficient targeted knock-in using CRISPR/Cas9 nickases2019
- Author(s)
  Md Lutfur Rahman, 兵頭寿典, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝, 小西裕之
- Organizer
  日本ゲノム編集学会第4回大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] p16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定2019
- Author(s)
  Sivasundaram Karnan, 太田明伸, 花村一朗, 村上秀樹, 兵頭寿典, 小西裕之, 都築忍, 細川好孝
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] CRISPR/Cas9 nickaseによるノックインはp53を活性化しない2019
- Author(s)
  兵頭寿典, Md Lutfur Rahman, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝, 小西裕之
- Organizer
  日本ゲノム編集学会第4回大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] p16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定2018
- Author(s)
  2.Sivasundaram Karnan, 太田明伸, 花村一朗, 村上秀樹, Md Wahiduzzaman, 兵頭寿典, 小西裕之, 都築忍, 細川好孝
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 悪性中皮腫細胞の増殖を特異的に抑制するAkt阻害剤の探索と同定2018
- Author(s)
  4.太田明伸, 山地雅之, Md Wahiduzzaman, Sivasundaram Karnan, 兵頭寿典, 小西裕之, 都築忍, 羽生田正行, 細川好孝
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 多発性骨髄腫の腫瘍増殖におけるPDZ binding kinaseの関与2018
- Author(s)
  3.太田明伸, 花村一朗, Sivasundaram Karnan, 小西裕之, 都築忍, 細川好孝
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 亜ヒ酸とシスプラチンによる併用療法はBcr-Abl陽性白血病細胞に対して相乗的な増殖抑制効果を示す2017
- Author(s)
  太田明伸, Md Wahiduzzaman, Sivasundaram Karnan, 兵頭寿典, 小西裕之, 都築忍, 細川好孝.
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] Combined arsenic trioxide-cisplatin treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells.2017
- Author(s)
  Md Wahiduzzaman, Akinobu Ota, Sivasundaram Karnan, Toshinori Hyodo, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 新規Interleukin-6誘導因子PDZ binding kinaseは骨髄腫細胞の増殖と進展に関与する.2017
- Author(s)
  太田明伸, 花村一朗, Sivasundaram Karnan, Md Wahiduzzaman, 兵頭寿典, 小西裕之, 都築忍, 細川好孝.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] SINGLE-NUCLEOTIDE POLYMORPHISM IN THE PBK GENE IS CLOSELY ASSOCIATED WITH MYELOMA CELL PROLIFERATION.2017
- Author(s)
  Ichiro Hanamura, Akinobu Ota, Sivasundaram Karnan, Md Wahiduzzaman, Shohei Mizuno, Kaori Uchino, Jo Kanasugi, Tomohiro Horio, Satsuki Murakami, Susumu Suzuki, Ryuzo Ueda, Shinobu Tsuzuki, Hiroyuki Konishi, Yoshitaka Hosokawa, Akiyoshi Takami.
- Organizer
  The 22nd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] Protein phosphatase 2Aの調節サブユニットPPP2R5Eは微小管架橋因子MTCL1の発現量を制御する.2017
- Author(s)
  兵頭寿典, 稲見恵理, 太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 悪性胸膜中皮腫の早期診断腫瘍マーカーの検討.2017
- Author(s)
  Sivasundaram Karnan, 太田明伸, 花村一朗, 村上秀樹, 兵頭寿典, Md Wahiduzzaman, 小西裕之, 都築忍, 細川好孝.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] CRISPR/Cas9を用いたNF2ノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析2017
- Author(s)
  Sivasundaram Karnan, 太田明伸, 花村一朗, 村上秀樹, 兵頭寿典, Md Wahiduzzaman, 小西裕之, 都築忍, 細川好孝.
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] Combined arsenic trioxide-cisplatin treatment enhances apoptosis in leukemic cell lines2016
- Author(s)
  Md Wahiduzzaman, Akinobu Ota, Sivasundaram Karnan, Hiroyuki Konishi, Yoshitaka Hosokawa
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城・仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 悪性胸膜中皮腫の早期診断の腫瘍マーカーの検討2016
- Author(s)
  Sivasundaram Karnan, 太田明伸, Md Wahiduzzaman, 小西裕之, 細川好孝
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城・仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 遺伝子改変・ゲノム編集効率を測定するアッセイ系としてのPIGA遺伝子の利用2016
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 肝がん細胞株におけるp53アイソフォームdelta40p53の性状解析2016
- Author(s)
  太田明伸, Md Wahiduzzaman, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城・仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] NOX1はAKTシグナルを介して口腔扁平上非癌細胞の生存に寄与する2016
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 風岡宜暁, 細川好孝
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] CRISPR-Cas9システムによる変異ノックイン ― プロモータートラップ法の比較検討2016
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝
- Organizer
  日本ゲノム編集学会第1回大会
- Place of Presentation
  広島国際会議場（広島・広島）
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 癌原性KRAS変異をノックインしたヒト気管支上皮細胞株モデルの樹立と解析2015
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] 1.400KオリゴアレイCGHを用いたNF1患者の皮膚神経線維腫の解析2015
- Author(s)
  Sivasundaram Karnan, 太田明伸, 小西裕之, 細川好孝
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] 口腔がん細胞株に対するプランバギンのプロオキシダント作用とアポトーシス誘導にはミトコンドリア遺伝子発現系が関与する2015
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] Delta40p53はHepG2細胞に対して細胞増殖抑制効果を示す2015
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] Delta40p53はHepG2細胞に対して細胞増殖抑制効果を示す2015
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 癌原性KRAS変異をノックインしたヒト気管支上皮細胞株モデルの樹立と解析2015
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 400KオリゴアレイCGHを用いたNF1患者の皮膚神経線維腫の解析2015
- Author(s)
  Sivasundaram Karnan, 太田明伸, 小西裕之, 細川好孝
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 口腔がん細胞株に対するプランバギンのプロオキシダント作用とアポトーシス誘導にはミトコンドリア遺伝子発現系が関与する2015
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] ヒ素は酸化LDL受容体LOX-1の発現を増加させることによりマウス血管内皮細胞の酸化LDL取り込み能を増強する.2013
- Author(s)
  太田明伸, Ekhtear Hossain, Sivasundaram Karnan, Damdindorj Lkhagvasuren, 小西裕子, 小西裕之, 細川好孝.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] KRAS変異およびPIK3CA変異のノックインを施したヒト上皮細胞株の生化学的解析.2013
- Author(s)
  Sivasundaram Karnan, 太田明伸, 細川好孝, 小西裕之.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] Arsenic trioxide inhibits interferon-gamma-mediated nitric oxide production in mouse vascular endothelial cells.2013
- Author(s)
  Hossain E, Ota A, Karnan S, Damdindorj L, Konishi Y, Konishi H, Hosokawa Y.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] Arsenic trioxide inhibits interferon-gamma-mediated nitric oxide production in mouse vascular endothelial cells.2013
- Author(s)
  Hossain E, Ota A, Karnan S, Damdindorj L, Konishi Y, Konishi H, Hosokawa Y.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] ヒト細胞株のゲノム編集によるKRAS-PI3Kシグナル経路の解析.2013
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] ヒ素は酸化LDL受容体LOX-1の発現を増加させることによりマウス血管内皮細胞の酸化LDL取り込み能を増強する.2013
- Author(s)
  太田明伸, Ekhtear Hossain, Sivasundaram Karnan, Damdindorj Lkhagvasuren, 小西裕子, 小西裕之, 細川好孝.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] ヒト細胞株のゲノム編集によるKRAS-PI3Kシグナル経路の解析.2013
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] 抗生剤耐性遺伝子-EGFP融合遺伝子を用いたヒト体細胞株の遺伝子ターゲッティング効率の定量2012
- Author(s)
  小西裕之
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-22500999
[Presentation] BRCA1ヘテロ変異によってヒト乳腺上皮細胞にゲノム不安定性が発生する2011
- Author(s)
  小西裕之
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22500999
[Presentation] A mutation in a single BRCA1 allele leads to genomic instability in human breast epithelial cells2011
- Author(s)
  Konishi H
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22500999
[Presentation] ヒト培養細胞遺伝子改変の新しい技術を用いた癌関連遺伝子の機能解析2010
- Author(s)
  小西裕之
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22500999
[Presentation] ヒト培養細胞遺伝子改変の新技術を用いた癌関連遺伝子の機能解析2010
- Author(s)
  小西裕之
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22500999
[Presentation] ヒト培養細胞遺伝子改変の新しい技術を用いた癌関連遺伝子の機能解析2010
- Author(s)
  小西裕之
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22500999
[Presentation] ヒト培養細胞遺伝子改変の新技術を用いた癌関連遺伝子の機能解析2010
- Author(s)
  小西裕之
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会館(大阪府)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22500999
[Presentation] A new protocol of somatic cell gene targeting in human cell lines and its application to breast cancer research2010
- Author(s)
  Konishi H
- Organizer
  The 15^<th> Japan-Korea Cancer Research Workshop
- Place of Presentation
  Sheraton Incheon Hotel (Incheon, Korea)
- Year and Date
  2010-12-22
- Data Source
  KAKENHI-PROJECT-22500999
[Presentation] A new protocol of somatic cell gene targeting in human cell lines and its application to breast cancer research2010
- Author(s)
  Konishi H
- Organizer
  第15回日韓がんワークショップ
- Place of Presentation
  仁川シェラトンホテル(仁川、大韓民国)
- Year and Date
  2010-12-22
- Data Source
  KAKENHI-PROJECT-22500999
[Presentation] リポポリサッカライドはErk1/2シグナルを介したLOX-1の発現増加によってマクロファージの酸化LDLの取り込みを増強する
- Author(s)
  太田明伸, Ekhtear Hossain, Sivasundaram Karnan, Shahnewaj Mannan, 小西裕之, 細川好孝
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都・京都）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] アデノ随伴ウイルスに基づく遺伝子改変ベクターにおいて薬剤耐性遺伝子の発現を制御するプロモーターと改変効率の関係
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] NF1関連の皮膚神経線維腫における400KオリゴアレイCGH解析
- Author(s)
  Sivasundaram Karnan, 太田明伸, 小西裕之, 細川好孝
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] プランバギンは口腔扁平上皮癌に対して活性酸素産生を介した細胞増殖抑制効果を示す
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 風岡宜暁, 細川好孝
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] リポポリサッカライドはErk1/2シグナルを介したLOX-1の発現増加によってマクロファージの酸化LDLの取り込みを増強する
- Author(s)
  太田明伸, Ekhtear Hossain, Sivasundaram Karnan, Shahnewaj Mannan, 小西裕之, 細川好孝
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都・京都）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] プランバギンは口腔扁平上皮癌に対して活性酸素産生を介した細胞増殖抑制効果を示す
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 風岡宜暁, 細川好孝
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] アデノ随伴ウイルスに基づく遺伝子改変ベクターにおいて薬剤耐性遺伝子の発現を制御するプロモーターと改変効率の関係
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] NF1関連の皮膚神経線維腫における400KオリゴアレイCGH解析
- Author(s)
  Sivasundaram Karnan, 太田明伸, 小西裕之, 細川好孝
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460395

1. HOSOKAWA Yoshitaka (60229193)

# of Collaborated Projects: 3 results

# of Collaborated Products: 49 results
2. SIVASUNDARAM Karnan (30557096)

# of Collaborated Projects: 3 results

# of Collaborated Products: 34 results
3. 兵頭寿典 (40710645)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
4. NAKAO Haruhisa (60326139)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAKADE Yukiomi (70431400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKAHASHI Takashi (50231395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. YANAGISAWA Kiyoshi (20372112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. TOMIDA Shuta (10372111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. YATABE Yasushi (90280809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. OSADA Hirotaka (30204176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. MASUDA Akira (50157202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. KOZAKI Kenichi (50270715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HANAMYRA Ichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
14. 太田明伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
15. 都筑忍

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 安田貴彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 高見昭良

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 岡田洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 伊藤卓治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Konishi Hiroyuki 小西 裕之

KONISHI Hiroyuki 小西 裕之

Research Projects

Research Products

Co-Researchers

高性能な改良型CRISPR/Cas9ゲノム編集システムの確立と応用展開Principal Investigator

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臨床応用を目指す高効率・高精度なCRISPRノックイン法の確立Principal Investigator

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Genome editing without DNA double-strand breaks mediated by CRISPR-Cas9 nickasesPrincipal Investigator

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Defining the KRAS signaling cascade using a genome-edited human bronchial epithelial cell line

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Development of a highly specific genome editing technology for human cells using adeno-associated viral vectorPrincipal Investigator

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The analysis of checkpoint mechanism of cell cycle in liver cancer cells

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Characterization of human BRCA1 heterozygous knockout cell lines created by somatic cell gene targetingPrincipal Investigator

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Multifaceted analysis of molecular pathogenesis of human lung cancers

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[Journal Article] CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia2021

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[Journal Article] CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia2021

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[Journal Article] Bi-allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells2020

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[Journal Article] Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia2020

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[Journal Article] Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells2020

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[Journal Article] Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma2020

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Konishi Hiroyuki 小西裕之

KONISHI Hiroyuki 小西裕之