Igarashi Junsuke 五十嵐淳介

… Alternative Names

IGARASHI Junsuke 五十嵐淳介

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Researcher Number	20346638
Affiliation (Current)	2025: 森ノ宮医療大学, 医療技術学部, 教授 2025: 森ノ宮医療大学, 保健医療学研究科, 教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 森ノ宮医療大学, 保健医療学研究科, 教授 2016: 香川大学, 医学部自律機能生理学講座, 准教授 2009 – 2015: Kagawa University, 医学部, 准教授 2003 – 2006: 香川大学, 医学部, 助教授 2004: Kagawa University, Faculty of Medicine, Associated Professor, 医学部, 助教授
Review Section/Research Field	Principal Investigator General physiology / Cardiovascular medicine / Circulatory organs internal medicine Except Principal Investigator Dermatology / Drug development chemistry / General physiology
Keywords	Principal Investigator サイトカイン / 脂質メディエーター / G蛋白質結合型受容体 / 成長因子 / 血管新生 / スフィンゴ脂質 / 血管内皮細胞 / 受容体 / 内皮細胞 / caveolin-1 … More / 受容体シグナリング / 細胞内情報伝達機構 / 心筋虚血 / 酸化ストレス / シグナルトランスダクション / G蛋白結合型受容体 / 内皮型NO合成酵素 … More Except Principal Investigator 血管新生 / 血管内皮細胞 / COA-Cl / コアクロル / 成長因子 / S1P1 / Nitric oxide / VEGF / 皮膚 / 核酸アナログ / 結合組織成長因子 / 線維芽細胞 / TGF-β / 全身性強皮症 / TGF / 強皮症 / CTGF / 線維化 / S1P1受容体アゴニスト / 2クロル炭素環オキセタノシンA / 核酸類縁体 / 構造活性相関 / 血管新生促進作用 / ２クロル炭素環オキセタノシンＡ / 血管新生促進剤 / 血管新生促進活性 / vascular endothelial cell / lipid / platelet / apoptosis / PDGF / 血管成熟 / カスパーゼ / 過酸化水素 / S1P / 脂質 / 血小板 / アポトーシス / Sphingosine-1 Phosphate / Arginine / Nitric oxide synthase / ROS / NADPH oxidase / G蛋白質結合型受容体 / 内皮型NO合成酵素 / スフィンゴ脂質 / スフィンゴシン1リン酸 / アルギニン / NO合成酵素 / 活性酸素 / NADPHオキシダーゼ / 角化細胞 / 表皮角化細胞 / 皮膚線維芽細胞 / カベオラ / 血管内皮 / カベオリン１ / シグナル伝達 / ステロイド / カベオリン Less

A novel angigenic agent COA-Cl prohibits fibrotic effect induced by CTGF in human fibroblasts.
- Principal Investigator
  
  KUBOTA YASUO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kagawa University
Vessel maturation by a cytokine TGFbeta1 and crosstalk with VEGFR2 signalingPrincipal Investigator
- Principal Investigator
  
  Igarashi Junsuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kagawa University
The effects of glucocorticoid on the expression of caveolin-1 in skin-related cells.
- Principal Investigator
  
  KUBOTA YASUO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kagawa University
Synthesis and evaluation of novel carbocyclic oxetanocin A (COA-Cl) derivatives as potential tube formation agents
- Principal Investigator
  
  Sakakibara Norikazu
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokushima Bunri University
Exploring the roles of sphingosine 1-phosphate(S1P), a lipid mediator, in ischemic heartPrincipal Investigator
- Principal Investigator
  
  IGARASHI Junsuke
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kagawa University
血管内皮細胞膜カベオラマイクロドメインによる活性酸素シグナル調節機構の解析Principal Investigator
- Principal Investigator
  
  五十嵐淳介
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Kagawa University
Cross-talk between S1P and VEGF in cutaneous vascular maturation, and its relationship to pathogenesis of psoriasis
- Principal Investigator
  
  KUBOTA Yasuo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kagawa University
脂質成長因子受容体EDG-1の血管内皮における発現調節機構の解析Principal Investigator
- Principal Investigator
  
  五十嵐淳介
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Kagawa University
  香川大学(医学部)
Molecular mechanism on the maturation of tissue oxygen supply system
- Principal Investigator
  
  KOSAKA Hiroaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kagawa University, Faculty of Medicine
  香川大学(医学部)

[Book] eNOS regulation by sphingosine 1-phosphate and caveolin. Advances in Molecular and Cell Biology, vol.36 : 125-140 (Edited by : E.Edward Bittar, Philippe G.Frank, and Michael P.Lisanti) ISBN : 0-44-451500-3.2005
- Author(s)
  Igarashi, J
- Total Pages
  16
- Publisher
  Elsevier Academic Press,アメリカ合衆国カリフォルニア州サンディエゴ市
- Data Source
  KAKENHI-PROJECT-17790151
[Journal Article] COA-Cl prevented TGF-β1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis.2019
- Author(s)
  Nakai K, Karita S, Igarashi J, Tsukamoto I, Hirano K, and Kubota Y
- Journal Title
  
  J Dermatol Sci
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10210
[Journal Article] Synthesis and evaluation of novel cyclopropane nucleoside as potential tube formation agents.2017
- Author(s)
  Sakakibara, N.; Igarashi, J.; Takata, M.; Konishi, R.; Kato, Y.; Tsukamoto, I.
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 未定
- NAID
  130005631529
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24790123
[Journal Article] Design, synthesis, and evaluation of novel 2-halogenated or aminated carbocyclic oxetanocin a analogs as potential angiogenic agents.2016
- Author(s)
  Sakakibara N, Igarashi J, Takata M, Konishi R, Suzue N, Kato Y, Maruyama T, and Tsukamoto I.
- Journal Title
  
  Heterocycles
  
  Volume: 印刷中
- NAID
  40020609194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461132
[Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts2016
- Author(s)
  Igarashi, J.; Okamoto, R.; Yamashita, T.; Hashimoto, T.; Karita, S.; Nakai, K.; Kubota, Y.; Takata, M.; Yamaguchi, F.; Tokuda, M.; Sakakibara, N.; Tsukamoto, I.; Konishi, R.; Hirano, K.
- Journal Title
  
  Physiological reports
  
  Volume: 4(6)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790123
[Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts.2016
- Author(s)
  Igarashi J, Okamoto R, Yamashita T, Hashimoto T, Karita S, Nakai K, Kubota Y, Takata M, Yamaguchi F, Tokuda M, Sakakibara N, Tsukamoto I, Konishi R, Hirano K.
- Journal Title
  
  Physiological Reports
  
  Volume: 4 Issue: 6 Pages: e12742-e12742
- DOI
  10.14814/phy2.12742
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461132
[Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts.2016
- Author(s)
  Igarashi, J.; Okamoto, R.; Yamashita, T.; Hashimoto, T.; Karita, S.; Nakai, K.; Kubota, Y.; Takata, M.; Yamaguchi, F.; Tokuda, M.; Sakakibara, N.; Tsukamoto, I.; Konishi, R.; Hirano, K.
- Journal Title
  
  Physiological reports
  
  Volume: 4(6)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790123
[Journal Article] Design, synthesis, and evaluation of novel 2-halogenated or aminated carbocyclic oxetanocin A analogs as potential angiogenic agents2015
- Author(s)
  Sakakibara, N.; Igarashi, J.; Takata, M.; Konishi, R.; Suzue, N.; Kato, Y.; Maruyama, T.; Tsukamoto, I.
- Journal Title
  
  Heterocycles
  
  Volume: 91(9) Pages: 1823-1832
- NAID
  40020609194
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24790123
[Journal Article] Synthesis and Evaluation of Novel Carbocyclic Oxetanocin A (COA-Cl) Derivatives as Potential Tube Formation Agents2015
- Author(s)
  N. Sakakibara,* J. Igarashi, M. Takata, Y. Demizu, T. Misawa, M. Kurihara, R. Konishi, Y. Kato, T. Maruyama, I. Tsukamoto
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 63 Issue: 9 Pages: 701-709
- DOI
  10.1248/cpb.c15-00386
- NAID
  130005096030
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-25461132
[Journal Article] Synthesis and evaluation of novel carbocyclic oxetanocin A (COA-Cl) derivatives as potential tube formation agents2015
- Author(s)
  Sakakibara, N.; Igarashi, J.; Takata, M.; Demizu, Y.; Misawa, T.; Kurihara, M.; Konishi, R.; Kato, Y.; Maruyama, T.; Tsukamoto, I.
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 63(9) Pages: 701-709
- NAID
  130005096030
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24790123
[Journal Article] Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes.2015
- Author(s)
  Hasan AU, Ohmori K, Konishi K, Igarashi J, Hashimoto T, Kamitori K, Yamaguchi
- Journal Title
  
  Mol Cell Endocrinol.
  
  Volume: 406 Pages: 10-18
- DOI
  10.1016/j.mce.2015.02.012
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591057, KAKENHI-PROJECT-25461132
[Journal Article] Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells2014
- Author(s)
  Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, TakuwaY, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I.
- Journal Title
  
  Pharmacology Research & Perspectives
  
  Volume: 2 Issue: 5 Pages: 68-68
- DOI
  10.1002/prp2.68
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390051, KAKENHI-PROJECT-24591654, KAKENHI-PROJECT-24790123, KAKENHI-PUBLICLY-25116711, KAKENHI-PROJECT-25461132, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26220203
[Journal Article] Lipid peroxidation-induced VEGF expression in the skin of KKAy obese mice2011
- Author(s)
  Nakai K, Yoneda, K, Ishihara Y, Ohmori K, Moriue T, Igarashi J, Kohno M, Kosaka H and Kubota Y
- Journal Title
  
  Experimental Dermatology
  
  Volume: 20(5) Pages: 388-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Reaction mechanism of single subunit NADH-ubiquinone oxidoreductase(Ndi1) from Saccharomyces cerevisiae : evidence for a ternary complex mechanism2011
- Author(s)
  Yang Y, Yamashita T, Nakamaru-Ogiso E, Hashimoto T, Murai M, Igarashi J, Miyoshi H, Mori N, Matsuno-Yagi A, Yagi T and Kosaka H
- Journal Title
  
  J Biol Chem
  
  Volume: 286(11) Pages: 9287-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Activation of vascular endothelial growth factor receptor 2 in a cellular model of loricrin keratoderma2010
- Author(s)
  Yoneda K, Demitsu T, Nakai K, Moriue T, Ogawa W, Igarashi J, Kosaka H, and Kubota Y
- Journal Title
  
  J Biol Chem
  
  Volume: 285(21) Pages: 16184-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Expression of wild-type, but not mutant, loricrin causes programmed cell death in HaCaT keratinocytes2010
- Author(s)
  Yoneda K, Demitsu T, Manabe M, Igarashi J, Kosaka H, Inagaki N, Takahashi H, Kon A, Kakuai M and Kubota Y
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 37(11) Pages: 956-64
- NAID
  10027572660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] A novel nucleic acid analogue shows strong angiogenic activity2010
- Author(s)
  Tsukamoto I, Sakakibara N, Maruyama T, Igarashi J, Kosaka H, Kubota Y, Tokuda M, Ashino H, Hattori K, Tanaka S, Kawata M and Konishi R
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 399(4) Pages: 699-704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Transforming Growth Factor-{ beta} 1 Down-Regulates Caveolin-1 Expression And Enhances Sphingosine 1-Phosphate Signaling In Cultured Vascular Endothelial Cells2009
- Author(s)
  Igarashi J, Shoji K, Hashimoto T, Moriue T, Yoneda K, Takamura T, Yamashita T, Kubota Y, and Kosaka H
- Journal Title
  
  Am. J. Physiol.(Cell Physiology)
  
  Volume: 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Transforming Growth Factor-{beta}1 Down-Regulates Caveolin-1 Expression And Enhances Sphingosine 1-Phosphate Signaling In Cultured Vascular Endothelial Cells2009
- Author(s)
  五十嵐淳介
- Journal Title
  
  Am.J.Physiol. (Cell Physiology) 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Statins induce S1P_1 receptors and enhance endothelial nitric oxide production in response to high density lipoproteins.2007
- Author(s)
  Igarashi J, Miyoshi M, Hashimoto T, Kubota Y, Kosaka H.
- Journal Title
  
  Br J Pharmacol 150(4)
  
  Pages: 470-479
- Data Source
  KAKENHI-PROJECT-17790151
[Journal Article] Hydrogen peroxide induces S1P_1 receptors and sensitizes vascular endothelial cells to sphingosine 1-phosphate, a platelet-derived lipid mediator.2007
- Author(s)
  Igarashi J, Miyoshi M, Hashimoto T, Kubota Y, Kosaka H.
- Journal Title
  
  Am. J. Physiol. (Cell Physiology) 292(2)
- Data Source
  KAKENHI-PROJECT-17790151
[Journal Article] The regulation and pharmacology of endothelial nitric oxide synthase.2006
- Author(s)
  Dudzinski DM, Igarashi J, Greif D, Michel T.
- Journal Title
  
  Annu Rev Pharmacol Toxicol. 46
  
  Pages: 235-276
- Data Source
  KAKENHI-PROJECT-17790151
[Journal Article] Statins and induction of S1P1 receptors : implications for enhanced endothelial responses for HDL (high density lipoproteins)2005
- Author(s)
  Igarashi, J
- Journal Title
  
  Circulation 112(17)
- Data Source
  KAKENHI-PROJECT-17790151
[Journal Article] Sphingosine 1-phosphate, a platelet-derived lipid growth factor, regulates angiogenesis (in Japanese)2005
- Author(s)
  Tetsuya Moriue, Yasuo Kubota, Junsuke Igarashi
- Journal Title
  
  Iyaku no mon 45-suppl.2
  
  Pages: 4-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591101
[Journal Article] 血小板由来生理活性脂質スフィンゴシン1リン酸による細胞機能調節2005
- Author(s)
  森上徹也, 窪田泰夫, 五十嵐淳介
- Journal Title
  
  医薬の門 45
  
  Pages: 4-7
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591101
[Journal Article] Effects of thiol antioxidant on NADPH oxidase in hypertensive dahl salt-sensitive rats.2004
- Author(s)
  Zhang L, Fujii S, Igarashi J, Kosaka, H.
- Journal Title
  
  Free Rad.Biol.Med. 37
  
  Pages: 1813-1820
- Data Source
  KAKENHI-PROJECT-15790119
[Journal Article] Effects of thiol antioxidant on NADPH Oxidase in hypertensive Dahl Salt-Sensitive Rats.2004
- Author(s)
  L Zhang, S Fujii, J Igarashi, H Kosaka
- Journal Title
  
  Free Radical Biology & Medicine 37
  
  Pages: 1813-1820
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590186
[Journal Article] Induction of LOX-1 and iNOS expression by ischemia-reperfusion and opposing effect of L-arginine2003
- Author(s)
  Kosaka H, Yoneyama H, Zhang L, Fujii S, Yamamoto A, Igarashi J
- Journal Title
  
  FASEB J 17
  
  Pages: 636-643
- Data Source
  KAKENHI-PROJECT-15790119
[Journal Article] Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and opposing effect of L-arginine.2003
- Author(s)
  H Kosaka, H Yoneyama, L Zhang, S Fujii, A Yamamoto, J Igarashi
- Journal Title
  
  FASEB J. 17
  
  Pages: 636-643
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590186
[Journal Article] Sphingosine 1-phosphate and control of vascular tone2003
- Author(s)
  Dantas APV, Igarashi J, Michel, T.
- Journal Title
  
  Am.J.Physiol 284
- Data Source
  KAKENHI-PROJECT-15790119
[Journal Article] L-Arginine reverses p47phox and gp91phox expression induced by high salt in Dahl rats2003
- Author(s)
  S Fujii, L Zhang, J Igarashi, H Kosaka
- Journal Title
  
  Hypertension 42
  
  Pages: 1014-1020
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590186
[Journal Article] Effects of high glucose on NOsynthesis in human keratinocyte cell line (HaCaT).2003
- Author(s)
  K.Nakai, S.Fujii, A.Yamamoto, J.Igarashi, Y.Kubota, H.Kosaka
- Journal Title
  
  J.Dermatological Science. 31
  
  Pages: 211-218
- NAID
  50000851268
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590186
[Journal Article] Vascular endothelial growth factor induces S1P1 receptors in endothelial cells : implications for cross-talk between sphingolipid and growth factor receptors.2003
- Author(s)
  Igarashi J, Erwin PAE, Dantas APV, Chen H, Michel T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 100
  
  Pages: 10664-10669
- Data Source
  KAKENHI-PROJECT-15790119
[Journal Article] L-Arginine reverses p47phox and gp91phox expression induced by high salt in Dahl rats.2003
- Author(s)
  Fujii S, Zhang L, Igarashi J, Kosaka, H.
- Journal Title
  
  Hypertension 42
  
  Pages: 1014-1020
- Data Source
  KAKENHI-PROJECT-15790119
[Journal Article] Receptor-regulated dynamic interaction between endothelial nitric oxide synthase and calmodulin revealed by fluorescence resonance energy transfer in living cells.2003
- Author(s)
  Jobin CM, Chen H, Lin A, Yacono PW, Igarashi J, Michel T, Golan DE.
- Journal Title
  
  Biochemistry 42
  
  Pages: 11716-11725
- Data Source
  KAKENHI-PROJECT-15790119
[Presentation] COA-Cl（コアクロル）による血管新生促進作用に関わる細胞内情報伝達の仕組み2016
- Author(s)
  五十嵐淳介
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  北海道札幌市
- Year and Date
  2016-03-22
- Invited
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] 血管新生促進剤を指向した2-クロル炭素環オキセタノシンA (COA-Cl)の新規2-置換型類縁体の創製研究2016
- Author(s)
  榊原紀和，五十嵐淳介，高田麻紀，小西良士，鈴江奈月,加藤善久，丸山徳見，塚本郁子
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] 2-クロル炭素環オキセタノシンA (COA-Cl)の新規2-置換型類縁体の合成とその血管新生促進作用2016
- Author(s)
  榊原紀和，五十嵐淳介，高田麻紀，小西良士，鈴江奈月，加藤善久，丸山徳見，塚本郁子
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] 新規核酸アナログCOA-Cl の神経保護栄養作用2016
- Author(s)
  塚本郁子，高田麻紀，窪田泰夫，徳田雅明，榊原紀和，五十嵐淳介，小西良士
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] アデノシンアナログCOA-Clの神経栄養／保護作用-(2)2016
- Author(s)
  塚本郁子，榊原紀和，五十嵐淳介，徳田雅明，窪田泰夫，高田麻紀，小西良士
- Organizer
  第89回日本生化学会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] 新規アデノシン類似化合物COA-Cl（コアクロル）はcAMP/CREB/PGC-1αの経路を介して血管内皮成長因子（VEGF）の産生を促進する2015
- Author(s)
  岡本隆司、五十嵐淳介、橋本剛、山下哲生、苅田咲子、窪田泰夫、高田麻紀、小西良士、塚本郁子、平野勝也
- Organizer
  第67回日本生理学会中国四国地方会
- Place of Presentation
  鳥取県米子市
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] A novel adenosine-like angiogenic agent COA-Cl elevates VEGF production via the transcription co-activator PGC-1α in cultured human fibroblasts.2015
- Author(s)
  Igarashi J, Tsukamoto I, Hirano K.
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] A Key Role of PGC-1α Co-transcription Factor, but not HIF1α Transcription Factor, in Production of Vascular Endothelial Growth Factor (VEGF) by a Novel Angiogenic Agent COA-Cl in Cultured Human Fibroblasts2015
- Author(s)
  Okamoto, R., Igarashi, J., Yamashita, T., Hashimoto, T., Karita, S., Shoji, K., Kubota, Y., Takata, M., Yamaguchi, F., Tokuda, M., Sakakibara, N., Tsukamoto, I., Konishi, R., Hirano, K.
- Organizer
  The American Heart Association’s Scientific Sessions 2015
- Place of Presentation
  アメリカ・フロリダ
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] Activation of cAMP/CREB/PGC-1α Pathway Plays a Key Role for a Novel Adenosine-like Angiogenic Agent COA-Cl to Induce Production of Vascular Endothelial Growth Gactor (VEGF) in Cultured Human Fibroblasts.2015
- Author(s)
  Okamoto R, Igarashi J, Hashimoto T, Yamashita T, Shoji K, Kubota Y, Sakakibara N, Tsukamoto I, Konishi R, Hirano K.
- Organizer
  Scientific Sessions 2015, American Heart Association
- Place of Presentation
  アメリカ合衆国フロリダ州オーランド市
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] 2-クロル炭素環オキセタノシンA (COA-Cl)の新規誘導体の合成とその血管新生促進作用2015
- Author(s)
  榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
- Organizer
  第45回複素環化学討論会
- Place of Presentation
  東京
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] A Key Role of PGC-1α Co-transcription Factor, but not HIF1α Transcription Factor, in Production of Vascular Endothelial Growth Factor (VEGF) by a Novel Angiogenic Agent COA-Cl in Cultured Human Fibroblasts.2015
- Author(s)
  Okamoto R, Igarashi J, Yamashita T, Takeshi Hashimoto T, Karita S, Shoji K, Kubota Y, Takata M, Yamaguchi F, Tokuda M, Sakakibara N, Tsukamoto I, Konishi R, Hirano K.
- Organizer
  Scientific Sessions 2015, American Heart Association
- Place of Presentation
  アメリカ合衆国フロリダ州オーランド市
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] 血管新生促進作用を有する新規2-クロル炭素環オキセタノシンA (COA-Cl)誘導体の創製2015
- Author(s)
  榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] 血管新生促進剤を指向した2-クロル炭素環オキセタノシンA(COA-Cl)の新規誘導体の創製研究2015
- Author(s)
  榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
- Organizer
  第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  高知
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] 新規核酸類似物質COA-Clによる血管新生反応におけるS1P1受容体の役割2014
- Author(s)
  五十嵐淳介、窪田泰夫、小路和代、榊原紀和、丸山徳見、高田真紀、小坂博昭、多久和陽、橋本剛、山下哲生、小西良二、塚本郁子
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島市
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] アデノシンアナログCOA-Clの神経栄養／保護作用2013
- Author(s)
  塚本郁子，榊原紀和，丸山徳見，五十嵐淳介，小坂博昭，徳田雅明，窪田泰夫，高田麻紀，小西良士
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] A newly synthesized adenosine analogue, COA-Cl has angiogenic potency2013
- Author(s)
  Tsukamoto, I., Takata, M., Sakakibara, N., Maruyama, T., Igarashi, J., Kosaka, H., Kubota, Y., Tokuda, M., Ashino, H., Hattori, K., Tanaka, S., Kawata, M., and Konishi, R.
- Organizer
  International Pharmaceutical Federation
- Place of Presentation
  Dublin, Ireland.
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] S1P1 Receptors Mediate Angiogenic Responses Of A Novel Adenosine Analogue COA-Cl In Human Umbilical Vein Endothelial Cells (HUVEC)2013
- Author(s)
  Junsuke Igarashi, Yasuo Kubota, Kazuyo Shoji, Norikazu Sakakibara, Tokumi Maruyama, Maki Takata, Hiroaki Kosaka, Ryoji Konishi, Ikuko Tsukamoto
- Organizer
  Scientific Sessions, American Heart Association
- Place of Presentation
  アメリカ合衆国テキサス州ダラス市
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] TGFβ1 down-regulates VEGFR-2 and attenuates VEGF-induced activation of protein kinase Akt in cultured endothelial cells2012
- Author(s)
  Igarashi J, Shoji K, Hashimoto T, Tsukamoto I, Yoneda K, Kubota Y, and Kosaka H
- Organizer
  日本生理学会
- Place of Presentation
  長野県松本市
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] TGFβ1 down-regulates VEGFR-2 and attenuates VEGF-induced activation of protein kinase Akt in cultured endothelial cells2012
- Author(s)
  Igarashi J., et al
- Organizer
  日本生理学会
- Place of Presentation
  長野県松本文化会館
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] ステロイド受容体アゴニストはcaveolin-1(cav-1)発現を増加させることで血管内皮のVEGF反応を抑制する2011
- Author(s)
  五十嵐淳介
- Organizer
  第40回日本心脈管作動物質学会
- Place of Presentation
  香川県高松市サンポート高松
- Year and Date
  2011-02-04
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] Glucocorticoid(GC) up-regulates expression of caveolin-1(cav-1) and attenuates VEGF responses in endothelial cells(EC)2011
- Author(s)
  Igarashi J, Shoji K, Hashimoto T, Yoneda K, Moriue T, Tsukamoto I, Kubota Y, and Kosaka H
- Organizer
  日本生理学会
- Place of Presentation
  誌上開催
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] 糖質コルチコイド(GC : glucocorticoid)はcaveolin-1(cav-1)の誘導を介して血管内皮細胞(EC : endothelial cells)におけるVEGF反応を減弱させる2011
- Author(s)
  五十嵐淳介
- Organizer
  第88回日本生理学会
- Place of Presentation
  誌上開催
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] ステロイド受容体アゴニストはcaveolin-1(cav-1)発現を増加させることで血管内皮のVEGF反応を抑制する2011
- Author(s)
  五十嵐淳介、小路和代、橋本剛、米田耕造、森上徹也、塚本郁子、窪田泰夫、小坂博昭
- Organizer
  日本心脈管作動物質学会
- Place of Presentation
  香川県高松市
- Year and Date
  2011-02-04
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] Steroid Hormones Induce Caveolin-1(cav-1) And Attenuate Vascular Endothelial Growth Factor (VEGF) Responses In Cultured Vascular Endothelial Cells(EC)2010
- Author(s)
  五十嵐淳介
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  アメリカ合衆国イリノイ州シカゴ市McCormick Place
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] Steroid Hormones Induce Caveolin-1(cav-1) And Attenuate vascular endothelial growth factor(VEGF) Responses In Cultured Vascular Endothelial Cells(EC)2010
- Author(s)
  Igarashi J, Hashimoto T, Shoji K, Yoneda K, Kubota Y, and Kosaka H
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  アメリカ合衆国イリノイ州シカゴ市
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] HUVECにおけるCOA-Clの血管新生作用に対するS1Pレセプターの関与
- Author(s)
  塚本郁子，五十嵐淳介，橋本剛，山下哲生，榊原紀和，丸山徳見，高田麻紀，窪田泰夫，平野勝也，小西良士
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24790123
[Presentation] アデノシン類似化合物COA-ClによるVEGF分泌促進機序の検討
- Author(s)
  岡本隆司五十嵐淳介山下哲生橋本剛平野勝也高田麻紀小西良士塚本郁子小路和代窪田泰夫
- Organizer
  第66回日本生理学会中国四国地方会
- Place of Presentation
  香川県高松市
- Year and Date
  2014-11-01 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] A novel angiogenic agent COA-Cl induced PGC-1α-mediated VEGF production in cultured human fibroblasts.
- Author(s)
  Okamoto R, Igarashi J, Yamashita T, Hashimoto T, Shoji K, Kubota Y, Takata M, Tsukamoto I, Konishi R, Hirano K
- Organizer
  第92回日本生理学会総会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-03-22 – 2015-03-24
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] 血管新生における内皮細胞の受容体シグナルの役割（教育講演）
- Author(s)
  五十嵐淳介
- Organizer
  第66回日本皮膚科学会西部支部学術大会
- Place of Presentation
  香川県高松市
- Year and Date
  2014-11-08 – 2014-11-09
- Invited
- Data Source
  KAKENHI-PROJECT-25461132

1. KOSAKA Hiroaki (60158897)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
2. KUBOTA YASUO (10126047)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. HASHIMOTO Takeshi (80380153)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
4. TSUKAMOTO Ikuko (10183477)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
5. FUJII Shigemoto (00325333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. Sakakibara Norikazu (10441594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
7. 中井浩三 (40363204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. HASAN Ul arif

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 多久和典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 岡本安雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 多久和陽

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 大森浩二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Igarashi Junsuke 五十嵐 淳介

IGARASHI Junsuke 五十嵐 淳介

Research Projects

Research Products

Co-Researchers

A novel angigenic agent COA-Cl prohibits fibrotic effect induced by CTGF in human fibroblasts.

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Vessel maturation by a cytokine TGFbeta1 and crosstalk with VEGFR2 signalingPrincipal Investigator

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The effects of glucocorticoid on the expression of caveolin-1 in skin-related cells.

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Synthesis and evaluation of novel carbocyclic oxetanocin A (COA-Cl) derivatives as potential tube formation agents

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Exploring the roles of sphingosine 1-phosphate(S1P), a lipid mediator, in ischemic heartPrincipal Investigator

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血管内皮細胞膜カベオラマイクロドメインによる活性酸素シグナル調節機構の解析Principal Investigator

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Cross-talk between S1P and VEGF in cutaneous vascular maturation, and its relationship to pathogenesis of psoriasis

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脂質成長因子受容体EDG-1の血管内皮における発現調節機構の解析Principal Investigator

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Molecular mechanism on the maturation of tissue oxygen supply system

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[Book] eNOS regulation by sphingosine 1-phosphate and caveolin. Advances in Molecular and Cell Biology, vol.36 : 125-140 (Edited by : E.Edward Bittar, Philippe G.Frank, and Michael P.Lisanti) ISBN : 0-44-451500-3.2005

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[Journal Article] COA-Cl prevented TGF-β1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis.2019

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[Journal Article] Synthesis and evaluation of novel cyclopropane nucleoside as potential tube formation agents.2017

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[Journal Article] Design, synthesis, and evaluation of novel 2-halogenated or aminated carbocyclic oxetanocin a analogs as potential angiogenic agents.2016

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NAID

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[Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts2016

Author(s)

Igarashi Junsuke 五十嵐淳介

IGARASHI Junsuke 五十嵐淳介