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Tanaka Motohiko  田中 基彦

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… Alternative Names

TANAKA Motohiko  田中 基彦

田中 基彦  タナカ モトヒコ

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Researcher Number 20346985
Other IDs
Affiliation (based on the past Project Information) *help 2020: 熊本大学, 大学院生命科学研究部(医), 特定研究員
2018 – 2019: 熊本大学, 大学院生命科学研究部(医), 准教授
2012 – 2014: 熊本大学, 生命科学研究部, 准教授
2003: 熊本大学, 大学院・医学薬学研究部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 53010:Gastroenterology-related
Except Principal Investigator
Gastroenterology / Gastroenterology
Keywords
Principal Investigator
予後 / 抵抗性 / 感受性 / 化学療法 / バイオインフォマティクス / CLU / 分子標的治療薬 / 治療抵抗性 / 分子標的治療 / NR-index … More / Clusterin / バイオマーカー / ソラフェニブ / 肝細胞癌 … More
Except Principal Investigator
Bcl-2 family / p38MAPK / 肝癌 / 細胞周期 / anti-cancer drug / liver cancer / apoptosis / Survival signal / 抗癌剤 / 肝細胞癌 / Bcl-2 / 抗がん剤 / PKA / Akt / 肝がん / アポトーシス / 生存シグナル / トランスクリプトーム / トランスクリプトーム / 肝再生 / p21 / G1 arrest / 接着因子 / 癌細胞 / senescence / ninjurin Less
  • Research Projects

    (4 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (9 People)
  •  Investigation on prediction for medical treatment response to advanced hepatocellular carcinomaPrincipal Investigator

    • Principal Investigator
      Tanaka Motohiko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kumamoto University
  •  Basic study of the cell cycle related molecules affiliated with liver regeneration and clinical application

    • Principal Investigator
      NAGAHAMA Hiroyasu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kumamoto University
  •  新規接着因子ninjurinの強制発現を用いたsenescence分子機構の解明

    • Principal Investigator
      SASAKI Yutaka
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Kumamoto University
      Osaka University
  •  Analysis of survival signaling and its application for a new therapeutic strategy of cancers in gastro-intestinal tract and liver.

    • Principal Investigator
      SASAKI Yutaka
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kumamoto University
      Osaka University

All 2021 2020 2019 2018 2004

All Journal Article Presentation

  • [Journal Article] Modified albumin?bilirubin grade to predict eligibility for second-line therapies at progression on sorafenib therapy in hepatocellular carcinoma patients2021

    • Author(s)
      Tokunaga Takayuki、Tanaka Motohiko、Tanaka Kentaro、Narahara Satoshi、Kawasaki Takeshi、Yoshimaru Yoko、Nagaoka Katsuya、Watanabe Takehisa、Tateyama Masakuni、Naoe Hideaki、Sasaki Yutaka、Tanaka Yasuhito
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Issue: 5 Pages: 922-932

    • DOI

      10.1007/s10147-020-01835-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17403, KAKENHI-PROJECT-18K07945, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-18H02798
  • [Journal Article] Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: A case control study.2020

    • Author(s)
      Masakuni Tateyama,Motohiko Tanaka, et al.
    • Journal Title

      BMC Gastroenterology

      Volume: 20 Pages: 371-371

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Journal Article] 薬剤性消化器疾患の治療 薬剤性消化器疾患の治療(3)肝臓2020

    • Author(s)
      長岡克弥、徳永尭之、田中基彦
    • Journal Title

      臨牀消化器内科

      Volume: 35 Pages: 3-3

    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Journal Article] Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions.2018

    • Author(s)
      4.Minayoshi Y, Maeda H, Yanagisawa H, Hamasaki K, Mizuta Y, Nishida K, Kinoshita R, Enoki Y, Imafuku T, Chuang VTG, Koga T, Fujiwara Y, Takeya M, Sonoda K, Wakayama T, Taguchi K, Ishima Y, Ishida T, Iwakiri Y, Tanaka M, Sasaki Y, Watanabe H, Otagiri M, Maruyama T.
    • Journal Title

      Drug delivery

      Volume: 25 Pages: 1067-1077

    • NAID

      120006941111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Journal Article] 2.Impact of surgical treatment after sorafenib therapy for advanced hepatocellular carcinoma.2018

    • Author(s)
      Takeyama H, Beppu T, Higashi T, Kaida T, Arima K, Taki K, Imai K, Nitta H, Hayashi H, Nakagawa S, Okabe H, Hashimoto D, Chikamoto A, Ishiko T, Tanaka M, Sasaki Y, Baba H.
    • Journal Title

      Surgery today

      Volume: 48 Pages: 431-438

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Journal Article] Interferon therapy for aged patients with chronic hepatitis C : improved survival in patients exhibiting a biochemical response.2004

    • Author(s)
      Imai, Y., Kasahara, A., Tanaka, H., Okanoue, T., Hiramatsu, N., Tsubouchi, H., Yoshioka, K., Kawata, S., Tanaka, E., Hino, K, Hayashi, K, Tamura, S., Itoh, Y., Sasaki, Y., Kiyosawa, K., Kakumu, S., Okita, K., Hayashi, N.
    • Journal Title

      J.Gastroenterol. 39

      Pages: 1069-1077

    • NAID

      10014116243

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370182
  • [Presentation] A NOVEL SERUM BIOMARKER, CLUSTERIN, AND RELATED PREDICTIVE INDEX SCORING COULD BE AN EARLY PREDICTOR OF RESPONSE TO SORAFENIB IN PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA.2020

    • Author(s)
      Satoshi Narahara, Motohiko Tanaka, et al.
    • Organizer
      Liver Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 肝炎ウイルス陽性患者の受診勧奨を目的とした肝臓非専門医療機関との診療連携システムの構築2020

    • Author(s)
      瀬戸山博子、田中基彦、佐々木裕
    • Organizer
      第106回日本消化器病学会総会 パネルディスカッション
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] C型慢性肝疾患,初発肝癌における高齢者に対する治療後の現状2020

    • Author(s)
      立山雅邦、田中基彦、佐々木裕
    • Organizer
      第106回日本消化器病学会総会 パネルディスカッション
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 翻訳後修飾の網羅的解析による肝癌の治療抵抗性の解明2020

    • Author(s)
      直江秀昭、渡邊丈久、田中基彦
    • Organizer
      第56回日本肝臓学会総会 シンポジウム
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] PROGNOSTIC FACTORS ASSOCIATED WITH SURVIVAL IN HEPATOCELLULAR CARCINOMA PATIENTS PROGRESSED ON LENVATINIB THERAPY, PREMISING SUBSEQUENT CHEMOTHERAPY2020

    • Author(s)
      Takayuki Tokunaga, Motohiko Tanaka, et al.
    • Organizer
      Liver Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] DAAs治療後の血清Exosome中miRNAの変化はSVR後の生体反応を反映する2020

    • Author(s)
      渡邊丈久、田中基彦
    • Organizer
      第56回日本肝臓学会総会 ワークショップ
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 肝細胞癌に対するソラフェニブの治療効果を早期に予測する血清バイオマーカーの解析2020

    • Author(s)
      楢原哲史、渡邊丈久、田中基彦
    • Organizer
      第56回日本肝臓学会総会 ワークショップ
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 当科における切除不能肝細胞癌に対するレンバチニブ治療の初期経験2019

    • Author(s)
      田中健太郎、德永尭之、楢原哲史、川崎剛、長岡克弥、吉丸洋子、
    • Organizer
      第105回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 肝癌分子標的治療薬の治療効果予測と耐性獲得機序の解析2019

    • Author(s)
      長岡克弥、楢原哲史、渡邊丈久、田中基彦、佐々木裕
    • Organizer
      第26回肝細胞研究会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 切除不能進行肝細胞癌に対するソラフェニブを基軸とした集学的治療戦略2019

    • Author(s)
      徳永尭之、田中基彦、田中健太郎、楢原哲史、吉丸洋子、川崎剛 長岡克弥 渡邊丈久 立山雅邦 佐々木裕
    • Organizer
      第105回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 進行肝細胞癌に対する集学的なソラフェニブ治療戦略2019

    • Author(s)
      徳永尭之、田中健太郎、楢原哲史、吉丸洋子、川崎剛、長岡克弥、渡邊丈久、立山雅邦、田中基彦、佐々木裕
    • Organizer
      第27回日本消化器関連学会週間
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 切除不能肝細胞癌に対する肝動脈化学塞栓療法から分子標的治療への適切な切り替えタイミング2019

    • Author(s)
      徳永尭之、田中基彦、佐々木裕
    • Organizer
      第55回日本肝癌研究会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] Optimal strategy of switching from transarterial chemoembolization to molecular targeted therapy for patients with unresectable hepatocellular carcinoma.2019

    • Author(s)
      Takayuki Tokunaga, Motohiko Tanaka, Kentaro Tanaka, Satoshi Narahara, Yoko Yoshimaru, Tekeshi Kawasaki, Katsuya Nagaoka, Takehisa Watanabe, Masakuni Tateyama, Yutaka Sasaki
    • Organizer
      The Liver Meeting (AASLD) 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] Multi-omics analyses identify nucleophosmin as a key regulator of apoptosis resistance in human hepatocellular carcinoma.2019

    • Author(s)
      Hideaki Naoe, Takehisa Watanabe, Katsuya Nagaoka, Nahoko Fujimoto, Norie Araki, Jiro Fujimoto, Motohiko Tanaka, Yutaka Sasaki
    • Organizer
      The Liver Meeting (AASLD) 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 肝細胞癌に対する肝動脈化学塞栓術から分子標的治療への適切な切り替えタイミングの検討2019

    • Author(s)
      徳永尭之、田中健太郎、楢原哲史、吉丸洋子、川崎剛、長岡克弥、渡邊丈久、立山雅邦、田中基彦、佐々木裕
    • Organizer
      第55回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] Altered microrna expression profiles in serum exosome links to clinical phenotypes induced by direct-acting antiviral therapy.2019

    • Author(s)
      Takehisa Watanabe, Nahoko Fujimoto, Katsuya, Satoshi Narahara, Kentaro Tanaka, Takayuki Tokunaga, Takeshi Kawasaki, Yoko Yoshimaru, Masakuni Tateyama, Hideaki Naoe, Motohiko Tanaka, Yutaka Sasaki
    • Organizer
      The Liver Meeting (AASLD) 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 当科における切除不能肝細胞癌に対するレンバチニブ治療の初期経験2019

    • Author(s)
      田中健太郎、徳永尭之、楢原哲史、川崎剛、長岡克弥、瀬戸山博子、吉丸洋子、渡邊丈久、立山雅邦、田中基彦、佐々木裕
    • Organizer
      第19回日本肝がん分子標的治療研究会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 肝内腫瘍量の多い切除不能進行肝細胞癌に対するlenvatinibの使用経験2019

    • Author(s)
      田中健太郎、楢原哲史、徳永尭之、川崎剛、長岡克弥、吉丸洋子、渡邊丈久、立山雅邦、田中基彦、佐々木裕
    • Organizer
      第20回日本肝がん分子標的治療研究会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 肝細胞癌に対するソラフェニブの治療効果を早期に予測する新規血清バイオマーカーの解析2019

    • Author(s)
      楢原哲史、渡邊丈久、長岡克弥、田中健太郎、徳永尭之、川崎剛、吉丸洋子、瀬戸山博子、立山雅邦、直江秀昭、田中基彦、佐々木裕
    • Organizer
      第55回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] C型慢性肝疾患,初発肝癌における高齢者に対する治療後の現状2019

    • Author(s)
      立山雅邦、田中基彦、佐々木裕
    • Organizer
      第105回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] Upregulation of secretory clusterin in response to sorafenib links to acquired treatment resistance of hepatocellular carcinoma.2019

    • Author(s)
      Satoshi Narahara, Takehisa Watanabe, Katsuya Nagaoka, Nahoko Fujimoto, Kentaro Tanaka, Takeshi Kawasaki, Yoko Yoshimaru, Masakuni Tateyama, Hideaki Naoe, Motohiko Tanaka, Yutaka Sasaki
    • Organizer
      The Liver Meeting (AASLD) 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] Analysis of the Changes of the Profiles of Exosomal miRNA in Serum of the Patients Induced By DAA Treatment.2018

    • Author(s)
      Takehisa Watanabe, Nahoko Fujimoto, Katsuya Nagaoka, Satoshi Narahara, Kentaro Tanaka, Takayuki Tokunaga, Takeshi Kawasaki, Youko Yoshimaru, Masakuni Tateyama, Hideaki Naoe, Motohiko Tanaka and Yutaka Sasaki.
    • Organizer
      The Liver Meeting (AASLD) 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] Early Prediction of Sorafenib Response in Patients with Hepatocellular Carcinoma: The Possible Role of Secretory Clusterin in Acquired Sorafenib Resistance.2018

    • Author(s)
      Narahara Satoshi, Watanabe Takehisa, Nagaoka Katsuya, Fujimoto Nahoko, Tanaka Kentaro, Tokunaga Takayuki, Kawasaki Takeshi, Yoshimaru Youko, Setoyama Hiroko, Tateyama Masakuni, Naoe Hideaki, Tanaka Motohiko, Sasaki Yutaka.
    • Organizer
      The Liver Meeting (AASLD) 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 進行肝細胞癌に対するソラフェニブ治療の効果解析から検討する後治療を見据えた治療戦略2018

    • Author(s)
      徳永尭之、田中基彦、田中健太郎、楢原哲史、川崎剛、吉丸洋子、渡邊丈久、瀬戸山博子、立山雅邦、佐々木裕
    • Organizer
      第54回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] Treatment Strategy Based on Sorafenib for Advanced Hepatocellular Carcinoma Premising Subsequent Treatment with Regorafenib.2018

    • Author(s)
      Tokunaga Takayuki, Tanaka Motohiko Tanaka Kentaro, Narahara Satoshi, Yoshimaru Yoko, Nagaoka Katsuya, Kawasaki Takeshi, Setoyama Hiroko, Watanabe Takehisa, Tateyama Masakuni, Sasaki Yutaka.
    • Organizer
      The Liver Meeting (AASLD) 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] Prognostic Factors in Patients with Advanced HCC Receiving Sorafenib or Hepatic Arterial Infusion Chemotherapy.2018

    • Author(s)
      Motohiko Tanaka, Takayuki Tokunaga, Kentaro Tanaka, Satoshi Narahara, Takeshi Kawasaki, Yoko Yoshimaru, Takehisa Watanabe, Masakuni Tateyama, Hideaki Naoe, Yutaka Sasaki.
    • Organizer
      The Asian Pacific Association for the Study of the Liver
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 進行肝細胞癌に対するソラフェニブ治療と肝動注化学療法の効果解析から検討する治療戦略.2018

    • Author(s)
      徳永尭之、田中基彦、佐々木裕.
    • Organizer
      第104回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 当科におけるSVR後肝癌の実態2018

    • Author(s)
      吉丸洋子、田中基彦、佐々木裕
    • Organizer
      第54回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 進行肝細胞癌に対する肝動注化学療法の効果解析から検討する治療戦略2018

    • Author(s)
      田中健太郎、徳永尭之、楢原哲史、川崎剛、吉丸洋子、渡邊丈久、瀬戸山博子、立山雅邦、田中基彦、佐々木裕
    • Organizer
      第54回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 11.TACE不応例に対する肝動注化学療法後に進行した肝細胞癌への後治療の検討2018

    • Author(s)
      田中健太郎、楢原哲史、徳永尭之、川崎剛、吉丸洋子、渡邊丈久、長岡克弥、立山雅邦、田中基彦、佐々木裕.
    • Organizer
      第112回日本消化器病学会九州支部例会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 当科における肝細胞癌根治例における抗ウイルス療法後の再発に関する検討2018

    • Author(s)
      立山雅邦、田中基彦、田中健太郎、楢原哲史、徳永尭之、川崎剛、吉丸洋子、渡邊丈久、佐々木裕.
    • Organizer
      第104回日本消化器病学会総会,
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 肝細胞癌に対するソラフェニブの治療効果を早期に予測する新規血清バイオマーカーの解析2018

    • Author(s)
      楢原哲史、渡邊丈久、田中健太郎、徳永尭之、川崎剛、吉丸洋子、立山雅邦、田中基彦、佐々木裕.
    • Organizer
      第54回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • [Presentation] 切除不能の門脈浸潤を伴う肝細胞癌に対する肝動注化学療法とソラフェニブ治療の効果解析から検討する治療戦略2018

    • Author(s)
      徳永尭之、田中基彦、佐々木裕.
    • Organizer
      第25回日本門脈圧亢進症学会総会
    • Data Source
      KAKENHI-PROJECT-18K07945
  • 1.  SASAKI Yutaka (70235282)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 30 results
  • 2.  NAGAHAMA Hiroyasu (60381000)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  NAOE Hideaki (30599246)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 4.  WATANABE Takehisa (20634843)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 24 results
  • 5.  TERASAKI Hisayasu (50381009)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  外山 隆
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  石田 永
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  大川 和良
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NAGAOKA KATSUYA
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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