IWAMARU Yoshifumi 岩丸祥史

… Alternative Names

Iwamaru Yoshifumi 岩丸祥史

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Researcher Number	20355142
Other IDs
Affiliation (Current)	2025: 国立研究開発法人農業・食品産業技術総合研究機構, 動物衛生研究部門, グループ長
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立研究開発法人農業・食品産業技術総合研究機構, 動物衛生研究部門, グループ長 2020 – 2021: 国立研究開発法人農業・食品産業技術総合研究機構, 動物衛生研究部門, グループ長補佐 2017 – 2020: 国立研究開発法人農業・食品産業技術総合研究機構, 動物衛生研究部門, ユニット長 2016: 国立研究開発法人農業・食品産業技術総合研究機構, 動物衛生研究部門越境性感染症研究領域, 上級研究員 2012: 独立行政法人農業・食品産業技術総合研究機構, プリオン病研究センター, 主任研究員 … More 2012: 独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所プリオン病研究センター, 主任研究員 2012: 独立行政法人農業・食品産業技術総合研究機構・動物衛生研究所, プリオン病研究チーム, 主任研究員 2011 – 2012: 独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所・プリオン病研究センター, 主任研究員 2011: 独立行政法人動物衛生研究所, プリオン病研究チーム, 主任研究員 2010: 独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所・プリオン病研究チーム, 主任研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 42020:Veterinary medical science-related / Veterinary medical science / Applied veterinary science Except Principal Investigator Basic Section 42020:Veterinary medical science-related / Basic Section 51030:Pathophysiologic neuroscience-related / Applied molecular and cellular biology
Keywords	Principal Investigator プリオン / 異常プリオン蛋白質 / 脂質ラフト / 神経細胞 / 高密度レクチンアレイ / グライコーム / 糖鎖 / レクチン / 糖鎖プロファイル / 持続感染細胞 … More / レクチンアレイ / 株 / スクレイピー / アスパラギン結合型糖鎖 / プリオン持続感染細胞 / プリオン病 / 細胞 / 共局在 / EMARS 反応 / 正常プリオン蛋白質 / 細胞表面 / 異常型プリオン蛋白質 / 感染細胞 / 標識 / 蛋白質 / GT1-7細胞 / FITC / 細胞膜 / 近接標識 / EMARS / 培養細胞 / ビオチン / DRM / GPIアンカー / ショ糖密度勾配遠心法 / N2a細胞 / プリオンタンパク質 / ラフト / 界面活性剤不溶膜画分 … More Except Principal Investigator プリオン / 牛海綿状脳症 / 試験管内増幅 / PMCA / BSE / 異常型プリオンタンパク質 / クロイツフェルトヤコブ病 / RT-QUIC法 / 培養細胞 / クロイツフェルト・ヤコブ病 / 異常型PrP / 孤発性クロイツフェルトヤコブ病 / PMCA法 / RT-QuIC法 / プリオン病 / P2×7受容体 / P2X7受容体 / P2X7 受容体 / ミクログリア Less

Elucidation of the origin of typical bovine spongiform encephalopathy
- Principal Investigator
  
  Imamura Morikazu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  University of Miyazaki
Analysis of prion strain generation based on glycosylation profile of disease associated prion proteinPrincipal Investigator
- Principal Investigator
  
  Iwamaru Yoshifumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  National Agriculture and Food Research Organization
Elucidation of the amplification mechanism using cultured human prion persistent infection cells and development of novel prevention and treatment for prion diseases
- Principal Investigator
  
  Atarashi Ryuichiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  University of Miyazaki
Comprehensive analyses of protein interactors of disease associated prion proteinPrincipal Investigator
- Principal Investigator
  
  Iwamaru Yoshifumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  National Agriculture and Food Research Organization
Study of the molecular mechanisms of abnormal prion protein (PrP) production by exploration of PrP-interacting molecules.Principal Investigator
- Principal Investigator
  
  IWAMARU Yoshifumi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  National Agriculture and Food Research Organization
Study on the molecular mechanisms of prion secretion from microglial cells
- Principal Investigator
  
  TAKENOUCHI Takato
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  National Institute of Agrobiological Sciences

All 2022 2019 2018 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] Role of autophagy in P2X7 receptor-mediated maturation and unconventional secretion of IL-1β in microglia. AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection2013
- Author(s)
  Takenouchi T, Sekiyama K, Tsukimoto M, Iwamaru Y, Fujita M, Sugama S, Kitani H, Hashimoto M.
- Publisher
  Elsevier (in press)
- Data Source
  KAKENHI-PROJECT-22580389
[Book] AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection (CHAPTER: ROLE OF AUTOPHAGY IN P2X7 RECEPTOR-MEDIATED MATURATION AND UNCONVENTIONAL SECRETION OF IL-1β IN MICROGLIA)2013
- Author(s)
  Takenouchi T, Sekiyama K, Tsukimoto M, Iwamaru Y, Fujita M, Sugama S, Kitani H, Hashimoto M
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-22580389
[Journal Article] Extended application of the rapid post‐mortem test kit for bovine spongiform encephalopathy to chronic wasting disease2022
- Author(s)
  Matsuura Yuichi、Miyazawa Kohtaro、Horiuchi Motohiro、Suzuki Akio、Yokoyama Mayumi、Imamura Morikazu、Ikeda Keigo、Iwamaru Yoshifumi
- Journal Title
  
  Microbiology and Immunology
  
  Volume: - Issue: 5 Pages: 212-215
- DOI
  10.1111/1348-0421.12968
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03119, KAKENHI-PROJECT-20K06403, KAKENHI-PROJECT-23K23772
[Journal Article] Spontaneous generation of distinct prion variants with recombinant prion protein from a baculovirus-insect cell expression system2022
- Author(s)
  Imamura M, Tabeta N, Iwamaru Y, Takatsuki H, Mori T, Atarashi R.
- Journal Title
  
  Biochem Biophys Res Commun .
  
  Volume: 613 Pages: 67-72
- DOI
  10.1016/j.bbrc.2022.04.137
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02721, KAKENHI-PROJECT-21K05938, KAKENHI-PROJECT-20K07807
[Journal Article] Prion replication elicits cytopathic changes in differentiated neurosphere cultures2013
- Author(s)
  Iwamaru Y, Takenouchi T, Imamura M, Shimizu Y, Miyazawa K, Mohri S, Yokoyama T, Kitani H
- Journal Title
  
  J Virol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23780313
[Journal Article] Cytochalasin D enhances the accumulation of a protease-resistant form of prion protein in ScN2a Cells: Involvement of PI3 kinase/Akt signaling pathway.2012
- Author(s)
  Takenouchi T. et al.
- Journal Title
  
  Cell Biol. Int.
  
  Volume: 36 Issue: 12 Pages: 1223-1231
- DOI
  10.1042/cbi20120329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390040, KAKENHI-PROJECT-22580389, KAKENHI-PROJECT-24500465, KAKENHI-PLANNED-22113009
[Journal Article] Anti-prion activity of Brilliant Blue G.2012
- Author(s)
  Iwamaru Y*, Takenouchi T*, Murayama Y, Okada H,Imamura M, Shimizu Y, Hashimoto M, Mohri S, Yokoyama T, Kitani H.
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 5 Pages: 37896-37896
- DOI
  10.1371/journal.pone.0037896
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580389, KAKENHI-PROJECT-23780313
[Journal Article] The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1b under acidic extracellular pH in LPS-primed microglial cells2011
- Author(s)
  T akenouchi T, Iwamaru Y, Sugama S, Tsukimoto M, Fujita M, Sekigawa A, Sekiyama K, Sato M, Kojima S, Conti B, Hashimoto M, Kitani H
- Journal Title
  
  J. Neurochem
  
  Volume: 117 Pages: 712-723
- DOI
  10.1111/j.1471-4159.2011.07240.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359, KAKENHI-PROJECT-21700399, KAKENHI-PROJECT-22580389
[Presentation] H-BSE prions adapted to ovine PrP in vitro acquired C-BSE-like properties.2022
- Author(s)
  Morikazu Imamura, Hiroyuki Okada, Kotaro Miyazawa, Yuichi Matsuura, Yoshifumi Iwamaru, Hanae Takatsuki, Tsuyoshi Mori, Ryuichiro Atarashi
- Organizer
  Asian Pacific Prion Symposium 2022
- Data Source
  KAKENHI-PROJECT-21K05938
[Presentation] Isolation of hidden minor prion conformers from classical scrapie isolates in advanced protein misfolding cyclic amplification in the presence of arginine ethyl ester.2019
- Author(s)
  Imamura M, Miyazawa K, Matsuura Y, Iwamaru Y, Kitamoto T, Mohri S, Takatsuki H, Mori T, Atarashi R
- Organizer
  Asian Pacific Prion Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02721
[Presentation] Immunolabeling of cell-surface abnormal prion protein in viable cells2018
- Author(s)
  Yoshifumi Iwamaru
- Organizer
  FEBS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08038
[Presentation] Immunolabeling of cell-surface abnormal prion protein in viable cells2018
- Author(s)
  Yoshifumi Iwamaru
- Organizer
  FEBS2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08038
[Presentation] プリオン感染N2a細胞での異常プリオン蛋白蓄積におけるアクチン骨格及びPI3キナーゼ経路の関与2013
- Author(s)
  竹之内敬人,岩丸祥史,今村守一,佐藤充,横山隆,毛利資郎,木谷裕
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台
- Year and Date
  2013-03-26
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] xploration of PrP-interacting molecules on the cell surface using the enzyme-mediated activation of radical sources reaction2012
- Author(s)
  岩丸祥史, 竹之内敬人, 今村守一, 毛利資郎,木谷裕, 横山隆
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23780313
[Presentation] P2X7 receptor-mediated pathways2012
- Author(s)
  Takenouchi T, Iwamaru Y, Tsukimoto M, Sato M, Kojima S, Hashimoto M, Kitani H.
- Organizer
  involved in the production and release of a 20-kDa form of IL-1β from LPS-primed microglial cells. Purine 2012
- Place of Presentation
  福岡
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] P2X7 receptor-mediated pathways involved in the production and release of a 20-kDa form of IL-1β from LPS-primed microglial cells.2012
- Author(s)
  Takenouchi T, Iwamaru Y, Tsukimoto M, Sato M, Kojima S, Hashimoto M, Kitani H
- Organizer
  Purine 2012
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] Brilliant blue G, an antagonist of the ATP sensitive receptor P2X7 prevents prion accumulation2011
- Author(s)
  Iwamaru Y, Takenouchi T, Imamura M, Shimizu Y, Murayama Y, Mohri S, Yokoyama T, Kitani H
- Organizer
  Prion 2011
- Place of Presentation
  モントリオール、カナダ
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] Brilliant blue G2011
- Author(s)
  Iwamaru Y, Takenouchi T, Imamura M, Shimizu Y, Murayama Y, Mohri S, Yokoyama T, Kitani H.
- Organizer
  an antagonist of the ATP sensitive receptor P2X7 prevents prion accumulation. Prion 2011
- Place of Presentation
  モントリオール、カナダ
- Year and Date
  2011-05-17
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] Anti-prion activity of Brilliant blue G, an antagonist of the ATP-sensitive receptor P2X72011
- Author(s)
  Iwamaru Y, Takenouchi T, Imamura M, Shimizu Y, Murayama Y, Mohri S, Yokoyama T, Kitani H
- Organizer
  Asian Pacific Prion Symposium 2011
- Place of Presentation
  軽井沢
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] P2X7受容体活性化に伴うミクログリアからの20-kDa IL-1βフラグメントの産生機構2011
- Author(s)
  竹之内敬人、岩丸祥史、洲鎌秀永、月本光俊、佐藤充、小島周二、橋本款、木谷裕
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] P2X7受容体活性化に伴うミクロクリアからの20-kDa IL-1βフラグメントの産生機構2011
- Author(s)
  竹之内敬人、岩丸祥史、洲鎌秀永、月本光俊、佐藤充、小島周二、橋本款、木谷裕
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] Anti-prion activityof Brilliant blue G2011
- Author(s)
  Iwamaru Y, Takenouchi T, Imamura M, Shimizu Y, Murayama Y, Mohri S, Yokoyama T, Kitani H.
- Organizer
  an antagonist of the ATP-sensitive receptor P2X7. Asian Pacific Prion Symposium 2011
- Place of Presentation
  軽井沢
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] P2X7受容体阻害剤Brilliant Blue Gは持続感染細胞におけるプリオン増殖を阻害する2010
- Author(s)
  岩丸祥史, 竹之内敬人, 清水善久, 今村守一, 村山裕一, 横山隆, 木谷裕
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  ホートアイランド(神戸)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] P2X7受容体阻害剤Brilliant Blue Gは持続感染細胞におけるプリオン増殖を阻害する2010
- Author(s)
  岩丸祥史,竹之内敬人,清水善久,今村守一,村山裕一,横山隆,木谷裕
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22580389
[Presentation] Exploration of PrP-interacting molecules on the cell surface using the enzyme-mediated activation of radical sources reaction.
- Author(s)
  岩丸祥史
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23780313

1. TAKENOUCHI Takato (20292518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
2. Atarashi Ryuichiro (90452846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. Imamura Morikazu (10391442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 舘野浩章 (30450670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Nakanishi Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SUGAMA Syuei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 堀内基広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IWAMARU Yoshifumi 岩丸 祥史

Iwamaru Yoshifumi 岩丸 祥史

Research Projects

Research Products

Co-Researchers

Elucidation of the origin of typical bovine spongiform encephalopathy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of prion strain generation based on glycosylation profile of disease associated prion proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the amplification mechanism using cultured human prion persistent infection cells and development of novel prevention and treatment for prion diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analyses of protein interactors of disease associated prion proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of the molecular mechanisms of abnormal prion protein (PrP) production by exploration of PrP-interacting molecules.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the molecular mechanisms of prion secretion from microglial cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Role of autophagy in P2X7 receptor-mediated maturation and unconventional secretion of IL-1β in microglia. AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection2013

Author(s)

Publisher

Data Source

[Book] AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection (CHAPTER: ROLE OF AUTOPHAGY IN P2X7 RECEPTOR-MEDIATED MATURATION AND UNCONVENTIONAL SECRETION OF IL-1β IN MICROGLIA)2013

Author(s)

Publisher

Data Source

[Journal Article] Extended application of the rapid post‐mortem test kit for bovine spongiform encephalopathy to chronic wasting disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spontaneous generation of distinct prion variants with recombinant prion protein from a baculovirus-insect cell expression system2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prion replication elicits cytopathic changes in differentiated neurosphere cultures2013

Author(s)

Journal Title

Data Source

[Journal Article] Cytochalasin D enhances the accumulation of a protease-resistant form of prion protein in ScN2a Cells: Involvement of PI3 kinase/Akt signaling pathway.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-prion activity of Brilliant Blue G.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1b under acidic extracellular pH in LPS-primed microglial cells2011

Author(s)

Journal Title

DOI

Data Source

[Presentation] H-BSE prions adapted to ovine PrP in vitro acquired C-BSE-like properties.2022

Author(s)

IWAMARU Yoshifumi 岩丸祥史

Iwamaru Yoshifumi 岩丸祥史