IWASE AKIRA 岩瀬明

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Iwase Akira 岩瀬明

IWASE Akira 岩瀬明

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Researcher Number	20362246
Other IDs
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Affiliation (Current)	2025: 群馬大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 群馬大学, 大学院医学系研究科, 教授 2014 – 2017: 名古屋大学, 医学部附属病院, 病院教授 2014: 名古屋大学, 医学部附属病院, 教授 2014: 名古屋大学, 大学院医学系研究科, 病院教授 2012 – 2013: 名古屋大学, 医学部附属病院, 准教授 … More 2011: 名古屋大学, 医学部・附属病院, 講師 2008 – 2011: Nagoya University, 医学部附属病院, 講師 2007: Nagoya University, 医学部・附属病院, 講師 2006: 名古屋大学, 医学部附属病院, 講師 2003 – 2006: 名古屋大学, 医学部附属病院, 助手 2005: 名古屋大学, 医学部付属病院, 助手 Less
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields Except Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related / Clinical nursing
Keywords	Principal Investigator 子宮内膜症 / 生殖医学 / 卵胞発育 / NEP / 間質細胞 / 細胞老化 / 炎症老化 / 卵巣予備能 / 微小環境 / 反復流産 … More / PCOS / FOXL2 / POTE / 自己抗体 / 自己免疫 / 卵巣機能不全 / マウスモデル / 局所炎症 / 線維化 / TCF21 / 卵巣組織培養 / タイムラプス / 体外培養 / 卵巣 / チョコレートのう胞 / Focal adhesion kinase / 腹膜播種 / チョコレート嚢胞 / 卵巣癌 / FF-MAS / コレステロール / スフィンゴシン1リン酸 / GDF-9 / S1P / コレステロール合成 / 脂質メディエーター / 顆粒膜細胞 / PTEN / 脱落膜化 / NEP, PTEN / デキサメサゾン / ERM / 細胞接着 / CD44 / プロゲステロン / 相互作用 / PI3K / Akt / ET-1 / 細胞内情報伝達 / 子宮内膜 … More Except Principal Investigator 卵胞発育 / 老化 / 線維化 / 炎症 / 子宮内膜症 / 酸化ストレス / 胎児プログラミング / IGF2 / インスリン抵抗性 / ゲノムインプリンティング / PCOS / 卵巣体外培養 / 経時的連続観察 / タイムラプス / 顆粒膜細胞 / 体外培養 / 卵巣組織培養 / パルス状LH分泌 / キスペプチン / 多嚢胞性卵巣症候群 / 不妊 / 不妊対処行動尺度 / 治療期間 / 年齢 / 性差 / 対処行動 / 不妊感情 / 心理的支援 / 不妊男性 / 卵巣過剰刺激症候群 / 着床 / 血管新生 / 脱落膜化 / 胚着床 / 子宮内膜 / ペプチダーゼ Less

Inflammaging－細胞老化を標的とした卵巣機能長寿化への挑戦Principal Investigator
- Principal Investigator
  
  岩瀬明
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Gunma University
細胞老化からアプローチする子宮内膜症の病態解明と新規治療の確立
- Principal Investigator
  
  中村智子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nagoya University
子宮内膜症微小環境の時空的プロファイリングと部位特異的内膜症形質の関連解析Principal Investigator
- Principal Investigator
  
  岩瀬明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Gunma University
The effect of endometriosis on granulosa cells in follicle growth
- Principal Investigator
  
  Nakamura Tomoko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nagoya University
Elucidation of pathogenesis and establishment of early diagnosis of autoimmune-related reproductive dysfunction by focusing on novel autoantibody-target antigensPrincipal Investigator
- Principal Investigator
  
  Akira Iwase
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Gunma University
A new animal model and cell lineages to investigate cancer-driver mutations in endometriosisPrincipal Investigator
- Principal Investigator
  
  Iwase Akira
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Gunma University
多嚢胞性卵巣症候群に関与するゲノムインプリンティング解析と発症予測マーカー考案
- Principal Investigator
  
  滝川幸子
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nagoya University
Integrated approach in investigation of gynecologic tumors based on their microenvironmentsPrincipal Investigator
- Principal Investigator
  
  Iwase Akira
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nagoya University
Elucidation of folliculogenesis by spatio-temporal investigationPrincipal Investigator
- Principal Investigator
  
  Iwase Akira
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nagoya University
time-lapse observations for ovarian
- Principal Investigator
  
  Goto Maki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nagoya University
Development of a new drug for ovulation induction targeted to central nervous system
- Principal Investigator
  
  NAKAHARA Tatsuo
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nagoya University
Analysis of lysophospholipid mediators in human follicle growth toward good-quality oocytesPrincipal Investigator
- Principal Investigator
  
  IWASE Akira
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nagoya University
Development of new strategy for treatment of endometriosis with focus on the interaction of NEP and PTENPrincipal Investigator
- Principal Investigator
  
  IWASE Akira
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nagoya University
着床成立に必要な子宮内膜細胞の機能的・形態学的分化における細胞内情報伝達系の解析Principal Investigator
- Principal Investigator
  
  岩瀬明
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nagoya University
不妊治療に臨む夫婦のリプロダクティブ・ヘルスケア-カップル支援有効性の検討-
- Principal Investigator
  
  渡邊実香
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Clinical nursing
- Research Institution
  Chubu University
  Nagoya University
分泌期子宮内膜のダイナミズムと胚着床・妊娠成立との時間的空間的関連性の解析
- Principal Investigator
  
  安藤寿夫
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nagoya University

[Journal Article] Tamoxifen Activates Dormant Primordial Follicles in Mouse Ovaries2022
- Author(s)
  Wei Wei、Komatsu Kouji、Osuka Satoko、Murase Tomohiko、Bayasula Bayasula、Nakanishi Natsuki、Nakamura Tomoko、Goto Maki、Iwase Akira、Masubuchi Satoru、Kajiyama Hiroaki
- Journal Title
  
  Reproductive Sciences
  
  Volume: Online ahead of print. Issue: 12 Pages: 3404-3412
- DOI
  10.1007/s43032-022-00896-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18217, KAKENHI-PROJECT-22K08246, KAKENHI-PROJECT-20H03819
[Journal Article] Effect of hypothyroidism and thyroid autoimmunity on the ovarian reserve: A systematic review and meta-analysis2021
- Author(s)
  Hasegawa Y, Kitahara Y, Osuka S, Tsukui Y, Kobayashi M, Iwase A.
- Journal Title
  
  Reprod Med Biol
  
  Volume: 21 Issue: 1
- DOI
  10.1002/rmb2.12427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03819
[Journal Article] Primate-specific POTE-actin gene could play a role in human folliculogenesis by controlling the proliferation of granulosa cells2021
- Author(s)
  Kasahara Y, Osuka S, Takasaki N, Bayasula, Koya Y, Nakanishi N, Murase T, Nakamura T, Goto M, Iwase A, Kajiyama H
- Journal Title
  
  Cell Death Discov
  
  Volume: 7 Issue: 1 Pages: 186-186
- DOI
  10.1038/s41420-021-00566-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03819, KAKENHI-PROJECT-20K18217
[Journal Article] Focal Adhesion Kinase-Mediated Sequences, Including Cell Adhesion, Inflammatory Response, and Fibrosis, as a Therapeutic Target in Endometriosis2020
- Author(s)
  Nagai Takashi、Ishida Chiharu、Nakamura Tomoko、Iwase Akira、Mori Masahiko、Murase Tomohiko、Bayasula、Osuka Satoko、Takikawa Sachiko、Goto Maki、Kotani Tomomi、Kikkawa Fumitaka
- Journal Title
  
  Reproductive Sciences
  
  Volume: 27 Issue: 7 Pages: 1400-1410
- DOI
  10.1007/s43032-019-00044-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09615
[Journal Article] Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice2020
- Author(s)
  Hayashi Shotaro、Nakamura Tomoko、Motooka Yashiro、Ito Fumiya、Jiang Li、Akatsuka Shinya、Iwase Akira、Kajiyama Hiroaki、Kikkawa Fumitaka、Toyokuni Shinya
- Journal Title
  
  Redox Biology
  
  Volume: 37 Pages: 101726-101726
- DOI
  10.1016/j.redox.2020.101726
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09615, KAKENHI-PUBLICLY-20H05502
[Journal Article] Involvement of Transcription Factor 21 in the Pathogenesis of Fibrosis in Endometriosis2020
- Author(s)
  Ganieva Umida、Nakamura Tomoko、Osuka Satoko、Bayasula、Nakanishi Natsuki、Kasahara Yukiyo、Takasaki Nobuyoshi、Muraoka Ayako、Hayashi Shotaro、Nagai Takashi、Murase Tomohiko、Goto Maki、Iwase Akira、Kikkawa Fumitaka
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 190 Issue: 1 Pages: 145-157
- DOI
  10.1016/j.ajpath.2019.09.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H05462, KAKENHI-PROJECT-19K22674
[Journal Article] Follicle dynamics: visualization and analysis of follicle growth and maturation using murine ovarian tissue culture.2018
- Author(s)
  Tomohiko Murase, Akira Iwase, Kouji Komatsu, Tomoko Nakamura, Satoko Osuka, Sachiko Takikawa, Maki Goto, Tomomi Kotani, Fumitaka Kikkawa
- Journal Title
  
  Journal of Assisted Reproduction and Genetics
  
  Volume: 35 Issue: 2 Pages: 339-343
- DOI
  10.1007/s10815-017-1073-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04984
[Journal Article] FOXL2C134W-induced CYP19 expression via cooperation with SMAD3 in HGrC1 cells.2018
- Author(s)
  Martina Belli, Nahoko Iwata, Tomoko Nakamura, Akira Iwase, Dwayne G Stupack, Shunichi Shimasaki
- Journal Title
  
  Endocrinology
  
  Volume: 159 Issue: 4 Pages: 1690-1703
- DOI
  10.1210/en.2017-03207
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04984
[Journal Article] PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing　TGF-β and TNF-α in mononuclear cells by insulin-sensitizing drugs.2017
- Author(s)
  Yamada-Nomoto K, Yoshino O, Akiyama I, Iwase A, Ono Y, Nakamura T, Harada M, Nakashima A, Shima T, Ushijima A, Osuga Y, Chang RJ, Shimasaki S, Saito S.
- Journal Title
  
  Am J Reprod Immunol.
  
  Volume: 78 Issue: 1 Pages: 1-8
- DOI
  10.1111/aji.12669
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462479, KAKENHI-PROJECT-15H04984
[Journal Article] CYP51A1 Induced by Growth Differentiation Factor 9 and Follicle-Stimulating Hormone in Granulosa Cells Is a Possible Predictor for Unfertilization2014
- Author(s)
  Nakamura T, Iwase A, Bayasula B, Nagatomo Y, Kondo M, Nakahara T, Takikawa S, Goto M, Kotani T, Kiyono T, Kikkawa F
- Journal Title
  
  Reproductive Sciences
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592468
[Journal Article] Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway2012
- Author(s)
  Nakahara T, Iwase A, Nakamura T, Kondo M, Bayasula, Kobayashi H, Takikawa S, Manabe S, Goto M, Kotani T, Kikkawa F.
- Journal Title
  
  Fertility and Sterility
  
  Volume: 98 Issue: 4 Pages: 1001-8
- DOI
  10.1016/j.fertnstert.2012.06.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592468
[Journal Article] Expression and localization of CXCL16 and CXCR6 in ovarian endometriotic tissues2011
- Author(s)
  Manabe S, Iwase A, Goto M, Kobayashi H, Takikawa S, Nagatomo Y, NakaharaT, Bayasula, Nakamura T, Hirokawa W, Kikkawa F
- Journal Title
  
  Arch Gynecol Obstet
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591912
[Journal Article] プロゲステロン依存性CD10発現の変化がCD44依存性細胞接着に影響を及ぼす2011
- Author(s)
  岩瀬明、永友良成、巴雅蘇拉、中村智子、廣川和加奈、中原辰夫、滝川幸子、小林浩治、真鍋修一、後藤真紀、吉川史隆
- Journal Title
  
  日本エンドメトリオーシス学会会誌
  
  Volume: 32巻 Pages: 84-87
- Data Source
  KAKENHI-PROJECT-20591912
[Journal Article] プロゲステロン依存性CD10発現の変化がCD44依存性細胞接着に影響を及ぼす2011
- Author(s)
  岩瀬明, ほか
- Journal Title
  
  日本エンドメトリオーシス学会会誌
  
  Volume: 32 Pages: 84-87
- Data Source
  KAKENHI-PROJECT-20591912
[Journal Article] Neutral endopeptidase expressed by decidualized stromal cells suppresses Akt phosphorylation and deoxyribonucleic acid synthesis induced by endothelin-1 in human endometrium2007
- Author(s)
  Akira Iwase, et. al.
- Journal Title
  
  Journal of Histochemistry and Cytochemistry 55(12)
  
  Pages: 1229-1235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17791114
[Journal Article] Neutral endopeptidase expressed by decidualized stromal cells suppresses Akt phosphorylation and deoxyribonucleic acid synthesis induced by endothelin-1 in human endometrium2006
- Author(s)
  Akira Iwase et al.
- Journal Title
  
  Endocrinology 147(11)
  
  Pages: 5153-5159
- Data Source
  KAKENHI-PROJECT-17791114
[Journal Article] Use of follicle-stimulating hormone test to predict poor response in in vitro fertilization.2005
- Author(s)
  Iwase A
- Journal Title
  
  Obstet Gynecol 105・3
  
  Pages: 645-652
- Data Source
  KAKENHI-PROJECT-15591741
[Presentation] 子宮内膜症における HtrA1の発現解析2024
- Author(s)
  津久井優美子、中村織江、長谷川祐子、小林　梓、井上直紀、北原慈和、岩瀬　明
- Organizer
  第45回エンドメトリオーシス学会
- Data Source
  KAKENHI-PROJECT-22K19594
[Presentation] Progesterone Modifies Fibrosis via Upregulation of Meflin Expression2023
- Author(s)
  井上直紀、北原慈和、平川隆史、岩瀬明
- Organizer
  第75回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K19594
[Presentation] FOXL2 expression in the ovary of women with PCOS2023
- Author(s)
  Hasegawa Y, Nakamura O, Inoue N, Iwase A
- Organizer
  IFFS World Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03819
[Presentation] 子宮内膜間質細胞におけるMeflin発現についての検討2023
- Author(s)
  井上直紀、中村織江、北原慈和、平川隆史、岩瀬明
- Organizer
  第28回生殖内分泌学会
- Data Source
  KAKENHI-PROJECT-22K19594
[Presentation] Meflin modifies fibroblastic properties in the process of decidualization2023
- Author(s)
  Inoue N, Nakamura O, Kitahara Y, Hirakawa T, Iwase A
- Organizer
  IFFS World Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19594
[Presentation] PCOSの病態・診断・治療－動物モデルから黄体補充まで2023
- Author(s)
  岩瀬　明
- Organizer
  第28回日本生殖内分泌学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03819
[Presentation] 子宮内膜間質細胞におけるMeflinの発現について2023
- Author(s)
  井上直紀、中村織江、北原慈和、平川隆史、岩瀬明
- Organizer
  第44回日本エンドメトリオーシス学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K19594
[Presentation] 転写因子FOXL2による多嚢胞性卵巣症候群の病態検討2023
- Author(s)
  長谷川祐子、岩瀬　明
- Organizer
  第96回日本内分泌学会
- Data Source
  KAKENHI-PROJECT-20H03819
[Presentation] 多嚢胞性卵巣症候群におけるFOXL2解析2022
- Author(s)
  長谷川祐子、北原慈和、津久井優美子、小林未央、岩瀬明
- Organizer
  日本生殖内分泌学会
- Data Source
  KAKENHI-PROJECT-20H03819
[Presentation] Expressions of transcription factor 21 and periostin in the eutopic endometrium of adenomyosis and endometriosis2021
- Author(s)
  Tomoko Nakamura, Umida Ganieva, Akira Iwase, Satoko Osuka, Shotaro Hayashi, Ayako Muraoka, Natsuki Nakanishi, Tomohiko Murase, Maki Goto, Hiroaki Kajiyama
- Organizer
  14th World Congress on Endometriosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09615
[Presentation] 新規卵巣子宮内膜症モデルマウスの確立と酸化ストレスによる卵胞機能、妊孕性の低下2021
- Author(s)
  林祥太郎、中村智子、田中秀明、曽根原玲菜、村上真由子、村岡彩子、仲西菜月、邨瀬智彦、大須賀智子、後藤真紀、岩瀬明、梶山広明
- Organizer
  第42回日本エンドメトリオーシス学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K09615
[Presentation] Expressions and Effects of Phoenixin and Its Receptor GPR173 During the Human Menstrual Cycle2020
- Author(s)
  Xuan Phuoc Nguyen, Tomoko Nakamura, Satoko Osuka, Bayasula Bayasula, Ayako Muraoka, Shotaro Hayashi, Natsuki Nakanishi, Yukiyo Kasahara, Tomohiko Murase, Maki Goto, Akira Iwase, Fumitaka Kikkawa
- Organizer
  Society for Reproductive Investigation 67th Annual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09615
[Presentation] Directive Action of Neuropeptide Phoenixin and Its Receptor GPR173 during Folliculogenesis2018
- Author(s)
  Phuoc Xuan Nguyen, Akira Iwase, Tomohiko Murase, Umida Ganieva, Ying Qin, Bayasula, Ken Shimizu, Satoko Osuka, Tomoko Nakamura, Maki Goto, Fumitaka Kikkawa
- Organizer
  65th Society for Reproductive Investigation Annual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] Exogenous GDF-9 Treatment Induces Follicular Development Through Downregulation of Anti-Mullerian Hormone Receptor as Visualized in the Sliced Ovarian Tissue Culture System2018
- Author(s)
  Tomohiko Murase, Akira Iwase, Kouji Komatsu, Wei Wei, Umida Ganieva, Bayasula, Ying Qin, Phuoc Xuan Nguyen, Sayako Yoshita, Ayako Muraoka, Shotaro Hayashi, Yukiyo Kasahara, Natsuki Nakanishi, Takashi Nagai, Ken Shimizu, Chiharu Ishida, Tomoko Nakamura, Satoko Osuka, Maki Goto, Fumitaka Kikkawa
- Organizer
  65th Society for Reproductive Investigation Annual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] ヒト顆粒膜細胞におけるゴナドトロピンレセプターの発現制御2017
- Author(s)
  清水顕、岩瀬明、Nguyen Xuan Phuoc、Ganieva Umida、Qin Ying、仲西菜月、笠原幸代、永井孝、邨瀬智彦、石田千晴、加藤奈緒、大須賀智子、中村智子、滝川幸子、後藤真紀、吉川史隆
- Organizer
  第21回日本生殖内分泌学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] 多嚢胞性卵巣症候群モデルラットにおけるエピジェネティック変異解析2017
- Author(s)
  大須賀智子、岩瀬明、仲西菜月、永井孝、笠原幸代、清水顕、邨瀬智彦、加藤奈緒、石田千晴、滝川幸子、後藤真紀、吉川史隆
- Organizer
  第69回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] Analysis of Follicular Growth and Oocyte Maturation in Cultured Murine Ovarian Tissue.2017
- Author(s)
  Tomohiko Murase, Akira Iwase, Phuoc Xuan Nguyen, Umida Ganieva, Ying Qin, Natsuki Nakanishi, Yukiyo Kasahara, Takashi Nagai, Ken Shimizu, Chiharu Ishida, Nao Kato, Satoko Osuka, Tomoko Nakamura, Sachiko Takikawa, Maki Goto, Fumitaka Kikkawa
- Organizer
  64th Society for Reproductive Investigation Annual Scientific Meeting
- Place of Presentation
  オーランド（アメリカ）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] Exogenous growth differentiation factor-9 treatment induces follicle development through downregulation of anti-Müllrian hormone receptor as visualized in the sliced ovarian tissue culture system.2017
- Author(s)
  Tomohiko Murase, Akira Iwase, Kouji Komatsu, Bayasula, Ying Qin, Phuoc Xuan Nguyen, Natsuki Nakanishi, Takashi Nagai, Ken Shimizu, Nao Kato, Satoko Osuka, Sachiko Takikawa, Maki Goto, Fumitaka Kikkawa
- Organizer
  4th World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] マウス卵巣組織培養による卵胞発育解析とBrdU免疫染色法を用いた顆粒膜細胞増殖の評価2017
- Author(s)
  邨瀬智彦、岩瀬明、Nguyen Xuan Phuoc、Ganieva Umida、Qin Ying、仲西菜月、笠原幸代、永井孝、清水顕、石田千晴、加藤奈緒、大須賀智子、中村智子、滝川幸子、後藤真紀、吉川史隆
- Organizer
  第21回日本生殖内分泌学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] 子宮内膜症進展機序におけるFocal Adhesion Kinaseの役割2017
- Author(s)
  永井孝、岩瀬明、石田千晴、加藤奈緒、大須賀智子、滝川幸子、後藤真紀、吉川史隆
- Organizer
  第38回日本エンドメトリオーシス学会
- Place of Presentation
  東京コンベンションホール（東京都中央区）
- Data Source
  KAKENHI-PROJECT-15K15603
[Presentation] ヒト顆粒膜細胞においてBMP15 はp38 MAPK 経路を介してFSHR を誘導する2017
- Author(s)
  清水顕，岩瀬明，林祥太郎，村岡彩子，吉田沙矢子，仲西菜月，笠原幸代，永井孝，石田千晴，加藤奈緒，邨瀬智彦，大須賀智子，巴雅蘇拉，中村智子，滝川幸子，後藤真紀，吉川史隆
- Organizer
  第62回日本生殖医学会学術講演会
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] Epigenetic regulation of gonadotropin receptor expression in human granulosa cells.2017
- Author(s)
  Ken Shimizu, Akira Iwase, Phuoc Xuan Nguyen, Ganieva Umida, Ying Qin, Bayasula, Natsuki Nakanishi, Takashi Nagai, Yukiyo Kasahara, Tomohiko Murase, Nao Kato, Chiharu Ishida, Satoko Osuka, Tomoko Nakamura, Sachiko Takikawa, Maki Goto, Fumitaka Kikkawa
- Organizer
  4th World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] Proteome analysis for ovarian autoimmunity in primary ovarian insufficiency (POI) patients.2017
- Author(s)
  Satoko Osuka, Akira Iwase, Yukiyo Kasahara, Shotaro Hayashi, Phuoc Xuan Nguyen, Ying Qin, Takashi Nagai, Ken Shimizu, Bayasula, Tomohiko Murase, Sachiko Takikawa, Maki Goto, Fumitaka Kikkawa
- Organizer
  4th World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] Prevention of chemotherapy-induced ovarian damage by the superoxide dismutase mimetic activity of mangafodipir.2017
- Author(s)
  Ying Qin, Akira Iwase, Bayasula, Tomohiko Murase, Satoko Osuka, Sachiko Takikawa, Maki Goto, Fumitaka Kikkawa
- Organizer
  4th World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] マウス卵巣組織培養による卵胞、卵母細胞の発育解析と顆粒膜細胞増殖の評価2017
- Author(s)
  邨瀬智彦、岩瀬明、仲西菜月、笠原幸代、永井孝、清水顕、石田千晴、加藤奈緒、大須賀智子、滝川幸子、後藤真紀、吉川史隆
- Organizer
  第69回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] 顆粒膜細胞におけるゴナドトロピンレセプターの発現制御2017
- Author(s)
  清水顕、岩瀬明、仲西菜月、笠原幸代、永井孝、石田千晴、加藤奈緒、邨瀬智彦、大須賀智子、滝川幸子、後藤真紀、吉川史隆
- Organizer
  第69回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] Growth Differentiation Factor 9 induces Granulosa Cell Proliferation via Inhibition of the Expression of AMH Type II Receptor.2017
- Author(s)
  Akira Iwase, Satoko Osuka, Bayasula, Sachiko Takikawa, Tomohiko Murase, Tomoko Nakamura, Maki Goto, Fumitaka Kikkawa
- Organizer
  64th Society for Reproductive Investigation Annual Scientific Meeting
- Place of Presentation
  オーランド（アメリカ）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] Phoenixin (PNX) and its novel receptor GPR173 in human ovary: Expression and regulation for steroidogenic enzymes.2017
- Author(s)
  Phuoc Xuan Nguyen, Akira Iwase, Tomohiko Murase, Ganieva Umida, Ying Qin, Bayasula, Ken Shimizu, Satoko Osuka, Sachiko Takikawa, Maki Goto, Fumitaka Kikkawa
- Organizer
  4th World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] Relationship between secretion of monocyte chemoattractant protein-1 and cell-extracellular matrix adhesion in endometriotic stroma cells.2016
- Author(s)
  Nagai T, Iwase A, Ishida C, Osuka S, Nakamura T, Takikawa S, Goto M, Kikkawa F.
- Organizer
  5th Asian Conference on Endometriosis
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2016-09-22
- Data Source
  KAKENHI-PROJECT-15K15603
[Presentation] マウス卵巣組織培養における卵胞発育解析とBrdU免疫染色法による顆粒膜細胞増殖の評価2016
- Author(s)
  邨瀬智彦, 岩瀬明, 仲西菜月, 笠原幸代, 清水顕, 石田千晴, 加藤奈緒, 大須賀智子, 中村智子, 滝川幸子, 後藤真紀, 吉川史隆
- Organizer
  第61回日本生殖医学会学術講演会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-03
- Data Source
  KAKENHI-PROJECT-26462485
[Presentation] Analysis of the Effect of Growth Factors on the Early Stages of Follicular Development in Cultured Murine Ovarian Tissue Through the Use of BrdU Immunostaining2016
- Author(s)
  邨瀬智彦、岩瀬　明
- Organizer
  63rd Annual Scientific Meeting of Society of Reproductive Investigation
- Place of Presentation
  Montreal (Canada)
- Year and Date
  2016-03-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] Increased secretion of monocyte chemoattractant protein-1 and myofibroblastic change is mediated by focal adhesion kinase in endometriotic stromal cells2016
- Author(s)
  岩瀬　明、石田千晴、永井　孝、邨瀬智彦、中村智子、滝川幸子、後藤真紀、吉川史隆
- Organizer
  63rdAnnual Scientific Meeting, Society of Reproductive Investigation
- Place of Presentation
  Montreal (Canada)
- Year and Date
  2016-03-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15603
[Presentation] マウス卵巣組織培養における卵胞発育解析とBrdU免疫染色法による顆粒膜増殖の評価2016
- Author(s)
  邨瀬智彦、岩瀬明、仲西菜月、笠原幸代、清水顕、石田千晴、加藤奈緒、大須賀智子、中村智子、滝川幸子、後藤真紀、吉川史隆
- Organizer
  第61回日本生殖医学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-03
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] マウス卵巣組織培養における初期卵胞発育因子の検討2016
- Author(s)
  邨瀬智彦, 加藤奈緒, 柵木善多, 笠原幸代, 永井孝, 清水顕, 大須賀智子, 中村智子, 滝川幸子, 後藤真紀, 岩瀬明, 吉川史隆
- Organizer
  第68回日本産科婦人科学会学術講演会
- Place of Presentation
  東京フォーラム（東京都中央区）
- Year and Date
  2016-04-22
- Data Source
  KAKENHI-PROJECT-26462485
[Presentation] マウス卵巣組織培養における初期卵胞発育因子の検討2016
- Author(s)
  邨瀬智彦, 加藤奈緒, 柵木善多, 笠原幸代, 永井孝, 清水顕, 大須賀智子, 中村智子, 滝川幸子, 後藤真紀, 岩瀬明, 吉川史隆
- Organizer
  第68回日本産科婦人科学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15H04984
[Presentation] 子宮内膜症におけるFocal adhesion kinase (FAK)とMonocyte chemotactic protein-1 (MCP-1)の関連2016
- Author(s)
  永井　孝、石田千晴、中村智子、滝川幸子、後藤真紀、岩瀬　明、吉川史隆
- Organizer
  第37回日本エンドメトリオーシス学会学術講演会
- Place of Presentation
  ホテル日航熊本（熊本県熊本市）
- Year and Date
  2016-01-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15603
[Presentation] Increased secretion of monocyte chemoattractant protein-1 in endometriotic stroma cells is mediated by cell-extracellular matrix adhesion and focal adhesion kinase2015
- Author(s)
  岩瀬　明
- Organizer
  5th Asian Congress on Endometriosis
- Place of Presentation
  Dead Sea (Jordan)
- Year and Date
  2015-11-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15603
[Presentation] TOR アクチベーター添加はヒト卵巣顆粒膜細胞の 4E－BP1 リン酸化と増殖を促す2015
- Author(s)
  邨瀬智彦,清水顕,大須賀智子.中村智子,中原辰夫,後藤真紀岩瀬明,吉川史隆
- Organizer
  第67回日本産科婦人科学会学術講演会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-04-10
- Data Source
  KAKENHI-PROJECT-26462485
[Presentation] PCOSモデルラットを用いたGnRH分泌調節機構の解析2013
- Author(s)
  近藤美佳、岩瀬明、齋藤愛、大須賀智子、森正彦、杉田敦子、中村智子、中原辰夫、後藤真紀、高橋秀憲、吉川史隆
- Organizer
  第31回日本受精着床学会総会・学術講演会
- Place of Presentation
  別府国際コンベンションセンター（別府市）
- Data Source
  KAKENHI-PROJECT-25861487
[Presentation] マウス視床下部由来不死化細胞株を用いたKNDyニューロン関連分子の発現解析2013
- Author(s)
  大須賀智子、中原辰夫、齋藤愛、森正彦、近藤美佳、巴雅蘇拉、杉田敦子、中村智子、高橋秀憲、後藤真紀、岩瀬明、吉川史隆
- Organizer
  第65回日本産科婦人科学会学術講演会
- Place of Presentation
  ロイトン札幌（札幌市）
- Data Source
  KAKENHI-PROJECT-25861487
[Presentation] 多嚢胞性卵巣症候群（PCOS）モデルラットにおけるゴナドトロピン分泌と視床下部キスペプチン発現の解析2013
- Author(s)
  齋藤愛、岩瀬明、中原辰夫、森正彦、大須賀智子、近藤美佳、杉田敦子、中村智子、高橋秀憲、後藤真紀、吉川史隆
- Organizer
  第31回日本受精着床学会総会・学術講演会
- Place of Presentation
  別府国際コンベンションセンター（別府市）
- Data Source
  KAKENHI-PROJECT-25861487
[Presentation] Investigation of the Kisspeptin /Neurokinin B /Dynorphin (KNDy) Neurons by using N-7 cells: immortalized hypothalamic cell line2013
- Author(s)
  Satoko Osuka, Akira Iwase, Tatsuo Nakahara, Mika Kondo, Maki Goto, Fumitaka Kikkawa
- Organizer
  Annual Meeting of American Society for Reproductive Medicine 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-25861487
[Presentation] PCOSラットモデルにおけるGnRH分泌調節機構の解析2013
- Author(s)
  近藤美佳, 岩瀬明, 巴雅蘇拉 , 齋藤愛, 大須賀智子, 森正彦, 杉田敦子, 中村智子, 中原辰夫, 後藤真紀, 高橋秀憲, 吉川史隆
- Organizer
  第65回日本産科婦人科学会学術講演会
- Place of Presentation
  ロイトン札幌（札幌市）
- Data Source
  KAKENHI-PROJECT-25861487
[Presentation] PCOSラットモデルにおけるLHパルス状分泌調節機構の解析2013
- Author(s)
  岩瀬明、近藤美佳、中原辰夫、大須賀智子、齋藤愛、後藤真紀、小谷友美、吉川史隆
- Organizer
  第86回日本内分泌学会学術総会
- Place of Presentation
  仙台国際センター（仙台市）
- Data Source
  KAKENHI-PROJECT-25861487
[Presentation] 子宮内膜症間質細胞においてNeutral endopeptidaseはプロゲステロンにより誘導され、細胞骨格-CD44結合を阻害し、細胞外マトリックスであるヒアルロン酸への接着を阻害する2011
- Author(s)
  岩瀬明, ほか
- Organizer
  第63回日本産科婦人科学会・学術講演会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2011-08-30
- Data Source
  KAKENHI-PROJECT-20591912
[Presentation] 子宮内膜症間質細胞においてneutral endopeptidaseはプロゲステロンにより誘導され、細胞骨格-CD44結合を阻害し、細胞外マトリックスであるヒアルロン酸への接着を阻害する2011
- Author(s)
  岩瀬明、後藤真紀、真鍋修一、中村智子、廣川和加奈、中原辰夫、小林浩治、滝川幸子、吉川史隆
- Organizer
  第63回日本産科婦人科学会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2011-08-30
- Data Source
  KAKENHI-PROJECT-20591912
[Presentation] 【ワークショップ】子宮内膜症の成因に関する基礎的研究,プロゲステロン依存性CD10発現の変化が、CD44依存性細胞接着に影響を及ぼす2011
- Author(s)
  岩瀬明、永友良成、巴雅蘇拉、中村智子、廣川和加奈、中原辰夫、滝川幸子、小林浩治、真鍋修一、後藤真紀、吉川史隆
- Organizer
  第32回日本エンドメトリオーシス学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2011-01-22
- Data Source
  KAKENHI-PROJECT-20591912
[Presentation] プロゲステロン依存性CD10発現の変化が、CD44依存性細胞接着に影響を及ぼす2011
- Author(s)
  岩瀬明, ほか
- Organizer
  第32回日本エンドメトリオーシス学会
- Place of Presentation
  都市センターホテル(東京)
- Year and Date
  2011-01-22
- Data Source
  KAKENHI-PROJECT-20591912
[Presentation] プロゲステロンにより誘導されるCD10は子宮内膜および内膜症間質細胞のCD44-ヒアルロン酸接着を阻害する2010
- Author(s)
  岩瀬明, ほか
- Organizer
  第62回日本産科婦人科学会学術講演会
- Place of Presentation
  東京国際フォーラム(東京)
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-20591912
[Presentation] PCOSにおけるGnRHパルス調節機構の検討
- Author(s)
  近藤美佳、岩瀬明、中原辰夫
- Organizer
  日本産科婦人科学会
- Place of Presentation
  東京国際フォーラム（東京都千代田区丸の内）
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-25861487
[Presentation] Proliferation and apoptosis of granulosa cell: A link to the folliculogenesis
- Author(s)
  Akira Iwase
- Organizer
  The 9th Conference of the Pacific Rim Society for Fertility and Sterility
- Place of Presentation
  神戸国際会議場（神戸）
- Invited
- Data Source
  KAKENHI-PROJECT-24592468
[Presentation] 多嚢胞性卵巣症候群(PCOS)モデルラットにおけるゴナドトロピン分泌と視床下部キスペプチン発現の解析
- Author(s)
  齋藤愛、岩瀬明、中原辰夫
- Organizer
  日本産科婦人科学会
- Place of Presentation
  東京国際フォーラム（東京都千代田区丸の内）
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-25861487
[Presentation] 胎生期アンドロゲン投与によるPCOSモデルラット作成、視床下部-下垂体-性腺軸における解析
- Author(s)
  大須賀智子、岩瀬明、中原辰夫
- Organizer
  日本生殖医学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2014-12-04 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-25861487
[Presentation] PCOSにおけるGnRHパルス調節機構の検討
- Author(s)
  近藤美佳、岩瀬明、中原辰夫
- Organizer
  日本生殖医学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2014-12-04 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-25861487

1. NAKAMURA Tomoko (40732681)

# of Collaborated Projects: 9 results

# of Collaborated Products: 29 results
2. GOTO Maki (90378125)

# of Collaborated Projects: 7 results

# of Collaborated Products: 37 results
3. 大須賀智子 (30778296)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
4. NAKAHARA Tatsuo (50534830)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
5. 小松紘司 (40456893)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
6. 安藤寿夫 (90273234)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 滝川幸子 (70456664)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
8. 北原慈和 (20714728)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. KONDO Mika

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
10. MURASE Tomohiko (90803114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
11. 水谷栄彦 (00159162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 渡邊実香 (70345908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 森田せつ子 (30182249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 平川隆史 (80375534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小谷友美 (70359751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 小林未央 (90827594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 仲西菜月 (30876404)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ISHIDA Chiharu

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
19. NAGAI Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
20. WEI wei

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. NGUYEN Phuoc Xuan

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
22. 吉川史隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 吉野修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IWASE AKIRA 岩瀬 明

Iwase Akira 岩瀬 明

IWASE Akira 岩瀬 明

Research Projects

Research Products

Co-Researchers

Inflammaging－細胞老化を標的とした卵巣機能長寿化への挑戦Principal Investigator

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細胞老化からアプローチする子宮内膜症の病態解明と新規治療の確立

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子宮内膜症微小環境の時空的プロファイリングと部位特異的内膜症形質の関連解析Principal Investigator

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The effect of endometriosis on granulosa cells in follicle growth

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Elucidation of pathogenesis and establishment of early diagnosis of autoimmune-related reproductive dysfunction by focusing on novel autoantibody-target antigensPrincipal Investigator

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A new animal model and cell lineages to investigate cancer-driver mutations in endometriosisPrincipal Investigator

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多嚢胞性卵巣症候群に関与するゲノムインプリンティング解析と発症予測マーカー考案

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Integrated approach in investigation of gynecologic tumors based on their microenvironmentsPrincipal Investigator

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Elucidation of folliculogenesis by spatio-temporal investigationPrincipal Investigator

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time-lapse observations for ovarian

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Development of a new drug for ovulation induction targeted to central nervous system

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Analysis of lysophospholipid mediators in human follicle growth toward good-quality oocytesPrincipal Investigator

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Development of new strategy for treatment of endometriosis with focus on the interaction of NEP and PTENPrincipal Investigator

Principal Investigator

IWASE AKIRA 岩瀬明

Iwase Akira 岩瀬明

IWASE Akira 岩瀬明

[Journal Article] PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing　TGF-β and TNF-α in mononuclear cells by insulin-sensitizing drugs.2017