Kotoku Naoyuki 古徳直之

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KOTOKU Naoyuki 古徳直之

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Researcher Number	20362618
Other IDs
Affiliation (Current)	2025: 立命館大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 立命館大学, 薬学部, 准教授 2015 – 2017: 大阪大学, 薬学研究科, 助教 2014 – 2015: 大阪大学, 大学院薬学研究科, 助教 2013 – 2015: 大阪大学, 薬学研究科(研究院), 助教 2009: 大阪大学, 大学院・薬学研究科, 助教 … More 2007 – 2009: Osaka University, 薬学研究科, 助教 2008: Osaka University, 大学院薬学研究科, 助教 2007: 大阪大学, 大学院・薬学研究科, 助教 2006: 大阪大学, 大学院薬学研究科, 助手 2005 – 2006: 大阪大学, 薬学研究科, 助手 2004 – 2005: 大阪大学, 大学院・薬学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Chemical pharmacy / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Basic Section 37030:Chemical biology-related / Natural medicines / Biomolecular chemistry Except Principal Investigator Biomolecular chemistry / Living organism molecular science / Basic Section 49030:Experimental pathology-related / Science and Engineering / Science and Engineering
Keywords	Principal Investigator 海洋天然物 / 抗がん剤 / 抗ガン剤 / 創薬化学 / リード化合物 / 血管新生 / 膵臓ガン / 作用メカニズム / 細胞内ラベル化 / 作用機序解明 … More / ガン細胞増殖メカニズム / がん微小環境 / 天然活性物質 / 抗がんリード化合物 / 活性発現の分子機構 / 全合成 / 活性天然物 / 構造活性相関 / 標的タンパク / プローブ分子 … More Except Principal Investigator 標的分子 / 海洋生物 / 活性天然物 / 抗がん剤 / ケミカルバイオロジー / 血管新生 / 海綿 / 接着分子 / アルツハイマー病 / 認知症 / 内在化 / 薬物送達系 / 経鼻的頭蓋内送達 / 抗体薬物複合体 / 癌 / がん / 感染症 / 医薬シーズ / 海洋薬物資源 / 分子標的治療 / 分子標的治療薬 / がん微小環境 / 生物活性物質 / プローブ分子 / 標的同定 / 低酸素環境適応 / 海洋微生物 / 微小環境 / 血管新生阻害 / 低酸素環境 / 血管新来生阻害 / 活性試験 / 分子標的 / 生態機能分子 / 多剤耐性克服物質 / 分化誘導物質 / p21プロモーター / 細胞周期阻害物質 / 細胞毒性物質 / 血管新生阻害物質 / 生体機能分子 Less

海洋天然物を起点とする膵臓ガン選択的増殖阻害剤の創製と薬剤耐性メカニズム解明Principal Investigator
- Principal Investigator
  
  古徳直之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Ritsumeikan University
Development of antibody drugs based on internalization of cell membrane proteins
- Principal Investigator
  
  Ito Akihiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Kindai University
Mechanistic studies of tumor cell growth using marine natural product and its application for anti-tumor drug discoveryPrincipal Investigator
- Principal Investigator
  
  Kotoku Naoyuki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Ritsumeikan University
Medicinal chemistry study of bioactive marine natural products targeting tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  KOTOKU NAOYUKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  Ritsumeikan University
  Osaka University
Exploring new drug targets based on binding protein identification of bioactive natural products
- Principal Investigator
  
  ARAI Masayoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Osaka University
Creation of novel molecular-targeted anticancer drugs focused on specific phenotypic changes of cells in tumor
- Principal Investigator
  
  KOBAYASHI Motomasa
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Osaka University
Development of short-step synthesis of probe molecules for accelerating target identification
- Principal Investigator
  
  KOBAYASHI Motomasa
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Osaka University
Target identification of cortistatin A and development of anti-cancer drug leadPrincipal Investigator
- Principal Investigator
  
  Kotoku Naoyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Osaka University
Search for medicinal seeds and analysis of their target molecules
- Principal Investigator
  
  Kobayashi Motomasa
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Osaka University
Search for molecular-targeted anti-cancer agents acting on the microenvironment in tumor and analysis of their target molecules
- Principal Investigator
  
  KOBAYASHI MOTOMASA
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Living organism molecular science
- Research Institution
  Osaka University
Synthetic studies of marine natural products having anti-angiogenic activitiesPrincipal Investigator
- Principal Investigator
  
  KOTOKU Naoyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
Search for Bioactive Natural Products for Molecular Target Chemotherapy of Cancer
- Principal Investigator
  
  KOBAYASHI Motomasa
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Living organism molecular science
- Research Institution
  Osaka University
血管新生を標的とする新規抗がんリード化合物の創製Principal Investigator
- Principal Investigator
  
  古徳直之
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
海洋生物由来の医薬シーズとしての生体機能分子の探索
- Principal Investigator
  
  KOBAYASHI Motomasa
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Osaka University

[Book] Chembiomolecular Science: At the Frontier of Chemistry and Biology2013
- Author(s)
  M. Kobayashi, N. Kotoku, M. Arai
- Total Pages
  270
- Publisher
  Springer-Verlag GmbH, Deutschland
- Data Source
  KAKENHI-PROJECT-22241053
[Journal Article] Unified Synthesis and Biological Evaluation of Makaluvamine J and Its Analogs2024
- Author(s)
  Kiichi, Y.; Fukuoka, K.; Kitano, A.; Ishino, K.; Kotoku, N.
- Journal Title
  
  Molecules
  
  Volume: 29 Issue: 6 Pages: 1389-1389
- DOI
  10.3390/molecules29061389
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K05339
[Journal Article] Oxidative Cyclization at ortho-Position of Phenol: Improved Total Synthesis of 3-(Phenethylamino)demethyl(oxy)aaptamine2023
- Author(s)
  Nakatani, Y.; Kimura, R.; Kimata, T.; Kotoku, N.
- Journal Title
  
  Marine Drugs
  
  Volume: 21 Issue: 5 Pages: 311-311
- DOI
  10.3390/md21050311
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K05339
[Journal Article] Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain2020
- Author(s)
  Masato Tanuma, Atsushi Kasai, Kazuki Bando, Naoyuki Kotoku, Kazuo Harada, Masafumi Minoshima, Kosuke Higashino, Atsushi Kimishima, Masayoshi Arai, Yukio Ago, Kaoru Seiriki, Kazuya Kikuchi, Satoshi Kawata, Katsumasa Fujita, Hitoshi Hashimoto
- Journal Title
  
  JCI Insight
  
  Volume: 5 Issue: 6
- DOI
  10.1172/jci.insight.133348
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05363, KAKENHI-PROJECT-18K19399, KAKENHI-PUBLICLY-18H05132, KAKENHI-PUBLICLY-19H05217, KAKENHI-PROJECT-17H02800, KAKENHI-PROJECT-17K19488, KAKENHI-PLANNED-18H05416, KAKENHI-PROJECT-17H03989, KAKENHI-PROJECT-17H05054, KAKENHI-PROJECT-20H00492, KAKENHI-PROJECT-18H02096
[Journal Article] Structure–Activity Relationship of Biakamide, Selective Growth Inhibitors under Nutrient-Starved Condition from Marine Sponge2019
- Author(s)
  Ryosuke Ishida, Hirokazu Matsumoto, Sayaka Ichii, Motomasa Kobayashi, Masayoshi Arai, Naoyuki Kotoku
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 3 Pages: 210-223
- DOI
  10.1248/cpb.c18-00587
- NAID
  130007606467
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-03-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05363, KAKENHI-PROJECT-17H04645, KAKENHI-PROJECT-18H02096
[Journal Article] Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II2017
- Author(s)
  Arai Masayoshi、Shin Dayoung、Kamiya Kentaro、Ishida Ryosuke、Setiawan Andi、Kotoku Naoyuki、Kobayashi Motomasa
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 71 Issue: 1 Pages: 44-49
- DOI
  10.1007/s11418-016-1025-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26305002, KAKENHI-PROJECT-26242074, KAKENHI-PROJECT-15H03114, KAKENHI-PROJECT-17H04645
[Journal Article] Biakamides A-D, Unique Polyketides from a Marine Sponge, Act as Selective Growth Inhibitors of Tumor Cells Adapted to Nutrient Starvation2017
- Author(s)
  Naoyuki Kotoku, Ryosuke Ishida, Hirokazu Matsumoto, Masayoshi Arai, Kazunari Toda, Andi Setiawan, Osamu Muraoka, and Motomasa Kobayashi
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 82 Issue: 3 Pages: 1705-1718
- DOI
  10.1021/acs.joc.6b02948
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07996, KAKENHI-PROJECT-16K08313, KAKENHI-PROJECT-26305002, KAKENHI-PROJECT-26242074, KAKENHI-PROJECT-15H03114, KAKENHI-PROJECT-17H04645
[Journal Article] New 3-alkylpyridine alkaloid, N-methylniphatyne A as an inhibitor of cancer cells adapted to nutrient starvation from an Indonesia marine sponge of Xestospongia sp.2016
- Author(s)
  Arai, M.; Kamiya, K.; Shin, D.; Matsumoto, H.; Hisa, T.; Setiawan, A.; Kotoku, N.; Kobayashi, M.
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102005
[Journal Article] Search for Anti-angiogenic Substances from Natural Sources2016
- Author(s)
  Kotoku, N.; Arai, M.; Kobayashi, M.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 64 Issue: 2 Pages: 128-134
- DOI
  10.1248/cpb.c15-00744
- NAID
  130005121723
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23102005, KAKENHI-PROJECT-26305002, KAKENHI-PROJECT-26242074, KAKENHI-PROJECT-15H03114
[Journal Article] Furospinosulin-1, marine spongean furanosesterterpene, suppresses the growth of hypoxia-adapted cancer cells by binding to transcriptional regulators p54nrb and LEDGF/p75.2016
- Author(s)
  Arai, M.; Kawachi, T.; Kotoku, N.; Nakata, C.; Kamada, H.; Tsunoda, S.; Tsutsumi, Y.; Endo, H.; Inoue, M.; Sato, H.; Kobayashi, M.
- Journal Title
  
  ChemBioChem
  
  Volume: 17 Issue: 2 Pages: 181-189
- DOI
  10.1002/cbic.201500519
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23102005, KAKENHI-PLANNED-26111005, KAKENHI-PROJECT-25461937, KAKENHI-PROJECT-26242074, KAKENHI-PROJECT-26305002
[Journal Article] Anti-dormant mycobacterial activity and target molecule of melophlins, tetramic acid derivatives isolated from a marine sponge of Melophlus sp.2016
- Author(s)
  M. Arai, Y. Yamano, K. Kamiya, A. Setiawan, M. Kobayashi
- Journal Title
  
  J. Nat. Med.
  
  Volume: 70 Issue: 3 Pages: 467-475
- DOI
  10.1007/s11418-016-1005-1
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26305002, KAKENHI-PROJECT-15H03114
[Journal Article] N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp.2016
- Author(s)
 M. Arai, K. Kamiya, D. Shin, H. Matsumoto, T. Hisa, A. Setiawan, N. Kotoku, M. Kobayashi
- Journal Title
 
 Chemical and Pharmaceutical Bulletin
 
 Volume: 64 Issue: 7 Pages: 766-771
- DOI
 10.1248/cpb.c16-00118
- NAID
 130005160059
- ISSN
 0009-2363, 1347-5223
- Language
 English
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-26242074, KAKENHI-PROJECT-26305002, KAKENHI-PROJECT-15H03114
[Journal Article] Enantioselective synthesis of dictyoceratin-A (smenospondiol) and -C, hypoxia-selective growth inhibitors from marine sponge2015
- Author(s)
  Yuji Sumii, Naoyuki Kotoku, Akinori Fukuda, Takashi Kawachi, Yuta Sumii, Masayoshi Arai, Motomasa Kobayashi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 23 Issue: 5 Pages: 966-975
- DOI
  10.1016/j.bmc.2015.01.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860065, KAKENHI-PROJECT-26242074, KAKENHI-PROJECT-15H03114
[Journal Article] Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.2015
- Author(s)
  Arai, M.; Kamiya, K.; Pruksakorn, P.; Sumii, Y.; Kotoku, N.; Joubert, J.-P.; Moodley, P.; Han, C.; Shin, D.; Kobayashi, M.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 13 Pages: 3534-3541
- DOI
  10.1016/j.bmc.2015.04.033
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102005, KAKENHI-PROJECT-26242074, KAKENHI-PROJECT-24310159, KAKENHI-PROJECT-26305002, KAKENHI-PROJECT-15H03114
[Journal Article] Structure-activity relationship and in vivo anti-tumor evaluation of dictyoceratin-A and -C, hypoxia-selective growth inhibitors from marine sponge.2015
- Author(s)
  Sumii, Y.; Kotoku, N.; Fukuda, A.; Kawachi, T.; Sumii, Y.; Arai, M.; Kobayashi, M.
- Journal Title
  
  Marine Drugs
  
  Volume: 13 Issue: 12 Pages: 7419-7432
- DOI
  10.3390/md13127074
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23102005, KAKENHI-PROJECT-26860065, KAKENHI-PROJECT-26242074, KAKENHI-PROJECT-15H03114
[Journal Article] Xylarianaphthol-1, a novel dinaphthofuran derivative, activates p21 promoter in a p53-independent manner.2014
- Author(s)
  N. Kotoku, K. Higashimoto, M. Kurioka, M. Arai, A. Fukuda, Y. Sumii, Y. Sowa, T. Sakai, M. Kobayashi
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Issue: 15 Pages: 3389-3391
- DOI
  10.1016/j.bmcl.2014.05.083
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23102005, KAKENHI-PROJECT-26242074
[Journal Article] Synthesis and evaluation of effective photoaffinity probe molecule of furospinosulin-1, a hypoxia-selective growth Inhibitor.2014
- Author(s)
  N. Kotoku, C. Nakata, T. Kawachi, T. Sato, X.H. Guo, A. Ito, Y. Sumii, M. Arai, M. Kobayashi
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22 Issue: 7 Pages: 2102-2112
- DOI
  10.1016/j.bmc.2014.02.026
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22241053, KAKENHI-PLANNED-23102005, KAKENHI-PROJECT-25750384, KAKENHI-PROJECT-26242074
[Journal Article] Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D22013
- Author(s)
 N. Kotoku, K. Mizushima, S. Tamura, M. Kobayashi
- Journal Title
 
 Chemical and Pharmaceutical Bulletin
 
 Volume: 61 Issue: 10 Pages: 1024-1029
- DOI
 10.1248/cpb.c13-00375
- NAID
 130004137256
- ISSN
 0009-2363, 1347-5223
- Language
 English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
 KAKENHI-PROJECT-22241053, KAKENHI-PLANNED-23102005, KAKENHI-PROJECT-24790109, KAKENHI-PROJECT-25750384
[Journal Article] Creation of Readily Accessible Analogue of Cortistatin A as an Antitumor Drug Lead2013
- Author(s)
  古徳直之
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 133 Issue: 8 Pages: 867-872
- DOI
  10.1248/yakushi.13-00159
- NAID
  130003361979
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2013-08-01
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22241053, KAKENHI-PLANNED-23102005
[Journal Article] Asymmetric Total Synthesis of (―)-Stenine and 9a-epi-Stenine.2012
- Author(s)
  Fujioka, H.; Nakahara, K.; Kotoku, N.; Ohba, Y.; Nagatomi, Y.; Wang, T.-L.; Sawama, Y.; Murai, K.; Hirano, K.; Oki, T.; Wakamatsu, S.; Kita, Y.
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 18 Issue: 43 Pages: 13861-13870
- DOI
  10.1002/chem.201200376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241053, KAKENHI-PROJECT-23390005, KAKENHI-PROJECT-23790011, KAKENHI-PROJECT-24659005, KAKENHI-PUBLICLY-24105516
[Journal Article] Creation of Readily Accessible and Orally Active Analogue of Cortistatin A.2012
- Author(s)
  Kotoku, N.; Sumii, Y.; Hayashi, T.; Tamura, S.: Kawachi, T.; Shiomura, S.; Arai, M.; Kobayashi, M.
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 3 Issue: 8 Pages: 673-677
- DOI
  10.1021/ml300143d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241053, KAKENHI-PROJECT-24790109, KAKENHI-PLANNED-23102005
[Journal Article] Concise synthesis and structure-activity relationship of furospinosulin-1, a hypoxia-selective growth inhibitor from marine sponge2011
- Author(s)
  Naoyuki Kotoku
- Journal Title
  
  Tetrahedron
  
  Volume: 67(35) Issue: 35 Pages: 6673-6678
- DOI
  10.1016/j.tet.2011.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241053, KAKENHI-PLANNED-23102005
[Journal Article] Stereoselective Synthesis of Core Structure of Cortistatin A2011
- Author(s)
  Naoyuki Kotoku
- Journal Title
  
  Org. Lett.
  
  Volume: 13(13) Issue: 13 Pages: 3514-3517
- DOI
  10.1021/ol201327u
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241053, KAKENHI-PLANNED-23102005
[Journal Article] Synthetic Study of Carbocyclic Core of Cortistatin A, an Anti-Angiogenic Steroidal Alkaloid from Marine Sponge2011
- Author(s)
  Naoyuki Kotoku
- Journal Title
  
  Heterocycles
  
  Volume: 83 Issue: 7 Pages: 1535-1552
- DOI
  10.3987/com-11-12195
- NAID
  40018854710
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102005
[Journal Article] Probe molecule equipped with boronic acid moiety as a reversible cross-linking group improves its binding affinity.2010
- Author(s)
  古徳直之、小林資正, ら
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume: 20 Pages: 4152-4155
- Data Source
  KAKENHI-PROJECT-22241053
[Journal Article] Synthesis of CD-ring structure of cortistatin A, an antiangiogenic steroidal alkaloid from marine sponge2008
- Author(s)
  Kotoku, N., Sumii, Y., Hayashi, T., Kobayashi, M.
- Journal Title
  
  Tetrahed. Lett. 49
  
  Pages: 7078-7081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201042
[Journal Article] Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge2008
- Author(s)
  N. Kotoku
- Journal Title
  
  Archiv der Pharmazie (Weinheim) 341
  
  Pages: 568-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073212
[Journal Article] Synthesis of CD-ring structure of cortistatin A, an anti-angiogenic steroidal alkaloid from marine sponge.2008
- Author(s)
  Kotoku, N.; Sumii, Y.; Hayashi, T.; Kobayashi, M.
- Journal Title
  
  Tetrahedron Lett. 49
  
  Pages: 7078-7081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790014
[Journal Article] Synthesis of BC-ring model of globostellatic acid X methyl ester, an anti-angiogenic substance from marine sponge2008
- Author(s)
  N. Kotoku
- Journal Title
  
  Bioorg. Med. Cheni. Lett 18
  
  Pages: 3532-3535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790014
[Journal Article] Synthesis of BC-ring model compound of globostellatic acid X methyl ester, an antiangiogenic substance from marine sponge.2008
- Author(s)
  Kotoku, N.; Tamada, N.; Hayashi, A.; Kobayashi, M.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 3532-3535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790014
[Journal Article] Structure-activity relationships study of bastadin 6, an anti-angiogenic bromi nated-tyrosine derived metabolite from marine sponge2008
- Author(s)
  N. Kotoku
- Journal Title
  
  Archly der Pharmazie (Weinheim) 341
  
  Pages: 568-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790014
[Journal Article] Synthesis of BC-ring model of globostellatic acid X methyl ester, an anti-angiogenic substance from marine sponge2008
- Author(s)
  N. Kotoku
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 3532-3535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201042
[Journal Article] Synthesis of CD-ring structure of cortistatin A, an anti-angiogenic steroidal alkaloid from marine sponge.2008
- Author(s)
  Kotoku, N. ; Sumii, Y. ; Hayashi, T. ; Kobayashi, M.
- Journal Title
  
  Tetrahed. Lett 49
  
  Pages: 7078-7081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201042
[Journal Article] Synthesis of CD-ring structure of cortistatin A, an anti-angiogenic ster oidal alkaloid from marine sponge2008
- Author(s)
  N. Kotoku
- Journal Title
  
  Tetrahedron Letters 49
  
  Pages: 7078-7081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201042
[Journal Article] Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge.2008
- Author(s)
  Kotoku, N. ; Hiramatsu, A. ; Tsujita, H. ; Hirakawa, Y. ; Sanagawa, M. ; Aoki, S. ; Kobayashi, M.
- Journal Title
  
  Arch. Pharm. (Weinheim) 341
  
  Pages: 568-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201042
[Journal Article] Synthesis of CD-ring structure of cortistatin A, an anti-angiogenic steroidal alkaloid from marine sponge2008
- Author(s)
  N. Kotoku
- Journal Title
  
  Tetrahedron Lett 49
  
  Pages: 7078-7081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790014
[Journal Article] Synthesis of CD-ring structure of cortistatin A, an anti-angiogenic steroidal alkaloid from marine sponge2008
- Author(s)
  N. Kotoku
- Journal Title
  
  Tetrahedron Letters 49
  
  Pages: 7078-7081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073212
[Journal Article] Structure-activity relationships study of bastadin 6, an antiangiogenic brominated-tyrosine derived metabolite from marine sponge2008
- Author(s)
  Kotoku, N. ; Hiramatsu, A. ; Tsujita, H. ; Hirakawa, Y. ; Sanagawa, M. ; Aoki, S. ; Kobayashi, M.
- Journal Title
  
  Arch. Pharm. (Weinheim) 341
  
  Pages: 568-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201042
[Journal Article] Synthesis of BC-ring model of globostellatic acid X methyl ester, an anti-angiogenic substance from marine sponge.2008
- Author(s)
  Kotoku, N. ; Tamada, N. ; Hayashi, A. ; Kobayashi, M.
- Journal Title
  
  Bioorg. Med. Chem. Lett 18
  
  Pages: 3532-3535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201042
[Journal Article] Structure-activity relationship (SAR) study of bastadin 6, an anti-angiogenic brominatedtyrosine derived metabolite from marine sponge.2008
- Author(s)
  Kotoku, N.; Hiramatsu, A.; Tsujita, H.; Hirakawa, Y.; Sanagawa, M.; Aoki, S.; Kobayashi, M.
- Journal Title
  
  Arch. Pharm. 341
  
  Pages: 568-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790014
[Journal Article] Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge2008
- Author(s)
  N. Kotoku
- Journal Title
  
  Archiv der Pharmazie (Weinheim) 341
  
  Pages: 568-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201042
[Journal Article] Synthesis of BC-ring model of globostellatic acid X methyl ester, an anti-angiogenic substance from marine sponge2008
- Author(s)
  N. Kotoku
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 3532-3535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073212
[Journal Article] Synthesis of BC-ring model of globostellatic acid X methyl ester, an antiangiogenic substance from marine sponge2008
- Author(s)
  Kotoku, N. ; Tamada, N. ; Hayashi, A. ; Kobayashi, M.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 3532-3535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201042
[Journal Article] Stereoselective total synthesis of arenastatin A, a spongean cytotoxic depsi peptide..2007
- Author(s)
  N. Kotoku
- Journal Title
  
  Tetrahedron Letters 48
  
  Pages: 7147-7150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201042
[Journal Article] Stereoselective total synthesis of arenastatinA, a spongean cytotoxic depsipeptide2007
- Author(s)
  N. kotoku
- Journal Title
  
  Tetrahedron Lett. 48
  
  Pages: 7147-7150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790014
[Journal Article] Stereoselective total synthesis of arenastatin A, a spongean cytotoxic depsipeptide.2007
- Author(s)
  Kotoku, N.; Narumi, F.; Kato, T.; Yamaguchi, M.; Kobayashi, M.
- Journal Title
  
  Tetrahedron Lett. 48
  
  Pages: 7147-7150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790014
[Journal Article] Stereoselective total synthesis of arenastatin A, a spongean cytotoxic depsi peptide2007
- Author(s)
  N. Kotoku
- Journal Title
  
  Tetrahedron Letters 48
  
  Pages: 7147-7150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073212
[Journal Article] Concise asymmetric total synthesis of scyphostatin, a potent inhibitor of neutral sphingomyelinase.2007
- Author(s)
  Fujioka, H.; Sawama, Y.; Kotoku, N.; Ohnaka, T.; Okitsu, T.; Murata, N.; Kubo, O.; Li, R.; Kita, Y.
- Journal Title
  
  Chem. Eur. J. 13
  
  Pages: 10225-10238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790014
[Journal Article] Synthesis of 15,20-triamide analogue with polar sustituent on the phenyl ring of arenastatin A, an extremely potent cytotoxic spongean depsipeptide2006
- Author(s)
  N.Kotoku
- Journal Title
  
  Bioorg.Med.Chem. 14
  
  Pages: 7446-7457
- Data Source
  KAKENHI-PROJECT-18201042
[Journal Article] Cortistatin A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex.2006
- Author(s)
  Aoki, S. ; Watanabe, Y. ; Sanagawa, M. ; Setiawan, A. ; Kotoku, N. ; Kobayashi, M.
- Journal Title
  
  J. Am. Chem. Soc 128
  
  Pages: 3148-3149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201042
[Journal Article] Synthesis of 15,20-triamide analogue with polar sustituent on the phenyl ring of arenastatin A, an extremely potent cytotoxic spongean depsipeptide2006
- Author(s)
  N.Kotoku
- Journal Title
  
  Bioorg. Med. Chem. 14
  
  Pages: 7446-7457
- Data Source
  KAKENHI-PROJECT-16073212
[Journal Article] Synthesis of 15,20-triamide analog with polar substituent on the phenyl ring of arenastatin A, an extremely potent cytotoxic spongean depsipeptide2006
- Author(s)
  N.Kotoku
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry 14(22)
  
  Pages: 7446-7457
- Data Source
  KAKENHI-PROJECT-17790014
[Journal Article] Cortistatin A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex2006
- Author(s)
  Aoki, S. ; Watanabe, Y. ; Sanagawa, M. ; Setiawan, A. ; Kotoku, N. ; Kobayashi, M.
- Journal Title
  
  J. Ame. Chem. Soc. 128
  
  Pages: 3148-3149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201042
[Journal Article] Absolute stereo-structure of kendarimide A, a novel MDR modulator, from a marine sponge.2005
- Author(s)
  N.Kotoku
- Journal Title
  
  Heterocycles 65
  
  Pages: 563-578
- NAID
  40006650944
- Data Source
  KAKENHI-PROJECT-16073212
[Journal Article] Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge.2005
- Author(s)
  N.Kotoku
- Journal Title
  
  Tetrahedron 61
  
  Pages: 7211-7218
- Data Source
  KAKENHI-PROJECT-16073212
[Journal Article] Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge2005
- Author(s)
  N.Kotoku
- Journal Title
  
  Tetrahedron 61(30)
  
  Pages: 7211-7218
- Data Source
  KAKENHI-PROJECT-17790014
[Patent] 抗がん物質のスクリーニング方法2012
- Inventor(s)
  小林資正, 荒井雅吉, 古徳直之, 河内崇志
- Industrial Property Rights Holder
  小林資正, 荒井雅吉, 古徳直之, 河内崇志
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-184400
- Filing Date
  2012-08-23
- Data Source
  KAKENHI-PROJECT-22241053
[Patent] 抗がん物質のスクリーニング方法2012
- Inventor(s)
  小林資正,荒井雅吉,古徳直之,河内崇志
- Industrial Property Rights Holder
  小林資正,荒井雅吉,古徳直之,河内崇志
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-184400
- Filing Date
  2012-08-23
- Data Source
  KAKENHI-PLANNED-23102005
[Patent] 新規コルチスタチンＡ類似体およびその用途2011
- Inventor(s)
  小林資正、古徳直之、荒井雅吉、田村理
- Industrial Property Rights Holder
  小林資正、古徳直之、荒井雅吉、田村理
- Industrial Property Rights Type
  特許
- Filing Date
  2011-09-16
- Overseas
- Data Source
  KAKENHI-PLANNED-23102005
[Patent] 新規プレニルアレーン化合物およびその用途2011
- Inventor(s)
  小林資正、古徳直之、荒井雅吉、河内崇志
- Industrial Property Rights Holder
  小林資正、古徳直之、荒井雅吉、河内崇志
- Industrial Property Rights Type
  特許
- Filing Date
  2011-05-06
- Overseas
- Data Source
  KAKENHI-PLANNED-23102005
[Patent] 新規プレニルアレーン化合物およびその用途2010
- Inventor(s)
  小林資正、古徳直之、荒井雅吉、河内崇志
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Number
  2010-209131
- Filing Date
  2010-05-07
- Data Source
  KAKENHI-PROJECT-22241053
[Patent] 新規コルチスタチンA類似体およびその用途2010
- Inventor(s)
  小林資正、古徳直之、荒井雅吉、田村理
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Number
  2010-209131
- Filing Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-22241053
[Patent] 新規プレニルアレーン化合物およびその用途2010
- Inventor(s)
  小林資正, 古徳直之, 荒井雅吉, 河内崇志
- Industrial Property Rights Holder
  国立大学法人大阪大学
- Industrial Property Number
  2010-107749
- Filing Date
  2010-05-07
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] Aaptamine骨格および誘導体の合成に向けた酸化的分子内環化反応の検討2024
- Author(s)
  中谷有輝、髙津仁志、木村理咲、古徳直之
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K05339
[Presentation] Total synthesis of 3-(phenethylamino)demethyl(oxy)aaptamine2023
- Author(s)
  Yuki Nakatani, Risa Kimura, Hitoshi Takatsu, Naoyuki Kotoku
- Organizer
  International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-15)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05339
[Presentation] Makaluvamine Jおよび誘導体の効率的合成法の開発2023
- Author(s)
  生一庸、石野航也、福岡光志郎、髙田壮太、高岡嵯月、古徳直之
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K05339
[Presentation] 抗腫瘍活性アルカロイドaleutianamineの合成研究2022
- Author(s)
  福岡光志郎、髙田壮太、古徳直之
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-22K05339
[Presentation] Synthesis and biological evaluation of novel analogs of arenastatin A by late-stage functionalization2021
- Author(s)
  Kohei Hatta, Maho Kishimoto, Yurina Mihara, Naoyuki Kotoku
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05363
[Presentation] Synthesis and Evaluation of Novel Analogs of Arenastatin A2019
- Author(s)
  Fujimoto, K.; Kishimoto, M.; Nakamura, S.; Nakanishi, I.; Kotoku, N.
- Organizer
  27th International Society of Heterocyclic Chemistry Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05363
[Presentation] In vivo imaging of alkynylated S-citalopram using surface-enhanced Raman scattering2019
- Author(s)
  Tanuma, M.; Kasai, A.; Bando, K.; Kotoku, N.; Higashino, K.; Ago, Y.; Kawata, S.; Fujita, K.; Hashimoto, H.
- Organizer
  SfN Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05363
[Presentation] Arenastatin Aの新規誘導体の合成研究2019
- Author(s)
  藤本晃規、岸本真歩、古徳直之
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K05363
[Presentation] Synthesis and mechanistic Studies of Biakamides, Naturally-occurring Anti-austerity Agents Targeting Mitochondria2018
- Author(s)
  Ryosuke Ishida, Hirokazu Matsumoto, Sayaka Ichii, Masayoshi Arai, Motomasa Kobayashi, Naoyuki Kotoku
- Organizer
  4th International Symposium for Medicinal Sciences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07996
[Presentation] 新規海洋天然物biakamide類の栄養飢餓環境選択的がん細胞増殖阻害活性とその作用メカニズム2017
- Author(s)
  ○石田良典, 古徳直之, 荒井雅吉
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-15H03114
[Presentation] 栄養飢餓環境選択的がん細胞増殖阻害活性物質biakamide類の合成研究と作用機序解析2017
- Author(s)
  石田良典、松本紘和、一井さやか、荒井雅吉、小林資正、古徳直之
- Organizer
  第59回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-15K07996
[Presentation] Structure-activity relationship and mechanistic analysis of biakamides, selective growth inhibitors against cancer cells under nutrient-starved conditions2017
- Author(s)
  Ryosuke Ishida, Naoyuki Kotoku, Hirokazu Matsumoto, Sayaka Ichii, Motomasa Kobayashi, Masayoshi Arai
- Organizer
  10th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences For Young Scientists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] 新規海洋天然物biakamide類の栄養飢餓環境選択的がん細胞増殖阻害活性とその作用メカニズム2017
- Author(s)
  石田良典, 古徳直之, 荒井雅吉
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] Structure-activity relationship and mechanistic analysis of biakamides, selective growth inhibitors against cancer cells under nutrient-starved conditions.2017
- Author(s)
  ○Ryosuke Ishida, Naoyuki Kotoku, Hirokazu Matsumoto, Sayaka Ichii, Motomasa Kobayashi, Masayoshi Arai
- Organizer
  The 10th Seoul-Kyoto-Osaka Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03114
[Presentation] 新規海洋天然物biakamide類の栄養飢餓環境選択的がん細胞増殖阻害活性とその作用メカニズム2017
- Author(s)
  石田良典、古徳直之、荒井雅吉
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-15K07996
[Presentation] 有機合成化学を基盤とする海洋天然物のケミカルバイオロジー研究2017
- Author(s)
  古徳直之
- Organizer
  第３７回有機合成若手セミナー～明日の有機合成を担う人のために～
- Invited
- Data Source
  KAKENHI-PROJECT-15K07996
[Presentation] 海綿由来ブロモフェノール類のグルコース飢餓環境選択的増殖阻害活性と作用メカニズム解析2017
- Author(s)
  古徳直之、申多英、石田良典、松本紘和、久智也、戸田和成、荒井雅吉、小林資正
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07996
[Presentation] 海綿由来ブロモフェノール類のグルコース飢餓環境選択的増殖阻害活性と作用メカニズム解析2017
- Author(s)
  古徳直之，申多英，石田良典，松本紘和，久智也，戸田和成，荒井雅吉，小林資正
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター等（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] 抗潜在性結核物質 3-(phenethylamino)dimethyl(oxy)aaptamine の構造活性相関研究2017
- Author(s)
  古徳直之、中村健彦、○野中宏起、山口亜由太、神谷謙太郎、小林資正、荒井雅吉
- Organizer
  第67回日本薬学会近畿支部大会
- Data Source
  KAKENHI-PROJECT-15H03114
[Presentation] 潜在性結核菌に対する抗菌物質nybomycinの標的分子解析2016
- Author(s)
  荒井雅吉，◯神谷謙太朗，住井裕司，申多英，Patamaporn Pruksakorn，韓智秀，古徳直之，小林資正
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 栄養飢餓環境選択的がん細胞増殖阻害物質biakamide類の構造活性相関と作用メカニズム解析2016
- Author(s)
  石田良典、古徳直之、松本紘和、荒井雅吉、小林資正
- Organizer
  第２１回天然薬物の開発と応用シンポジウム
- Place of Presentation
  千葉大学薬学部120周年記念講堂
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-15K07996
[Presentation] 低酸素環境選択的がん細胞増殖阻害物質dictyoceratin類の標的分子解析2016
- Author(s)
  古徳直之，荒井雅吉，河内崇志，住井裕司，福田昭典，田中駿，小林資正
- Organizer
  第58回天然有機化合物討論会
- Place of Presentation
  東北大学百周年記念会館（宮城県仙台市）
- Year and Date
  2016-09-14
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] 海洋生物由来の栄養飢餓選択的増殖阻害物質の探索と創薬への展開2016
- Author(s)
  古徳直之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-15K07996
[Presentation] 海洋天然物aaptamine類の潜在性結核菌に対する抗菌活性2016
- Author(s)
  荒井雅吉,○神谷謙太朗, 韓　智秀, 山野　喜, 住井裕司, 中村健彦, 古徳直之, 小林資正
- Organizer
  日本生薬学会第６４回年会
- Data Source
  KAKENHI-PROJECT-15H03114
[Presentation] 低酸素環境選択的がん細胞増殖阻害物質dictyoceratin類の標的分子解析2016
- Author(s)
  ○古徳直之，荒井雅吉，河内崇志，住井裕司，福田昭典，田中　駿，小林資正
- Organizer
  第５８回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-15H03114
[Presentation] 低酸素環境選択的増殖阻害物質dictyoceratin類の構造活性相関とin vivo抗腫瘍活性2016
- Author(s)
  住井裕司,　◯古徳直之，福田昭典，河内崇志，荒井雅吉，小林資正
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 海洋生物由来の栄養飢餓選択的増殖阻害物質の探索と創薬への展開2016
- Author(s)
  古徳直之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] 低栄養選択的がん細胞増殖阻害物質N-methylniphatyne Aの全合成2016
- Author(s)
  古徳直之，松本紘和，久智也，申多英，山口亞由太，荒井雅吉，小林資正
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学（大阪府高槻市）
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] 栄養飢餓環境選択的がん細胞増殖阻害物質biakamide類の構造活性相関と作用メカニズム解析2016
- Author(s)
  石田良典，古徳直之，松本紘和，荒井雅吉，小林資正
- Organizer
  第21回天然薬物の開発と応用シンポジウム
- Place of Presentation
  千葉大学薬学部（千葉県千葉市）
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] 海洋生物由来の栄養飢餓選択的増殖阻害物質の探索と創薬への展開2016
- Author(s)
  古徳直之
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-27
- Invited
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 海洋天然物を基軸とした創薬への挑戦2016
- Author(s)
  古徳直之
- Organizer
  第２回近畿薬学シンポジウム・化学系の若い力
- Place of Presentation
  大阪大学薬学部沢井ホール
- Year and Date
  2016-06-04
- Invited
- Data Source
  KAKENHI-PROJECT-15K07996
[Presentation] グルコース飢餓環境選択的増殖阻害物質biakamide類の構造活性相関研究2015
- Author(s)
  ◯石田良典，古徳直之，松本紘和，田畑奎太朗，小林資正
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪大谷大学（大阪府・富田林市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 低栄養選択的増殖阻害物質fasciospyrinadinoneの全合成2015
- Author(s)
  古徳直之，松本紘和，○久智也，戸田和成，荒井雅吉，小林資正
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪大谷大学
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15K07996
[Presentation] Cortistatin Aアナログ化合物の構造活性相関と標的同定への応用2015
- Author(s)
  古徳直之、伊藤　葵、○水野華奈子、渋谷俊一、小林資正
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸（兵庫県神戸市）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25750384
[Presentation] Cortistatin Aアナログ化合物の構造活性相関と標的同定への応用2015
- Author(s)
  古徳直之、伊藤　葵、◯水野華奈子、渋谷俊一、小林資正
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸（神戸）
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] Anti-dormant mycobacterial activity and action-mechanism of nybomycin produced by Streptomyces sp.2015
- Author(s)
  ◯Kentaro Kamiya, Masayoshi Arai, Patamaporn Pruksakorn, Yuji Sumii, Naoyuki Kotoku, Chisu Han, Dayoung Shin and Motomasa Kobayashi
- Organizer
  The 9th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
- Place of Presentation
  Seoul (Korea)
- Year and Date
  2015-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 低酸素環境選択的がん細胞増殖阻害物質dictyoceratin-Cの標的分子解析2015
- Author(s)
  河内崇志，荒井雅吉，古徳直之，小林資正
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル（愛媛県松山市）
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] 低酸素環境選択的がん細胞増殖阻害物質dictyoceratin-Cの標的分子解析2015
- Author(s)
  ○河内崇志，荒井雅吉，古徳直之，小林資正
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル（愛媛県松山市）
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-15H03114
[Presentation] 栄養飢餓環境選択的がん細胞増殖阻害物質の探索2015
- Author(s)
  荒井雅吉，◯申多英，松本紘和，神谷謙太朗，久智也，古徳直之，小林資正
- Organizer
  日本生薬学会第６２回年会
- Place of Presentation
  長良川国際会議場（岐阜県・岐阜市）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] グルコース飢餓環境選択的増殖阻害物質biakamide類の構造活性相関研究2015
- Author(s)
  ○石田良典，古徳直之，松本紘和，田畑奎太朗，小林資正
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪大谷大学（大阪府富田林市）
- Data Source
  KAKENHI-PROJECT-15H03114
[Presentation] 海綿由来環状デプシペプチドarenastatin Aの新規結合タンパク質の同定2015
- Author(s)
  ○荒井雅吉，河内崇志，高市伸宏，馬田哲也，古徳直之，小林資正
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  神奈川県民ホール（神奈川県横浜市）
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-15H03114
[Presentation] 低栄養選択的増殖阻害物質fasciospyrinadinoneの全合成2015
- Author(s)
  古徳直之，松本紘和，久智也，戸田和成，荒井雅吉，小林資正
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪大谷大学（大阪府富田林市）
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] グルコース飢餓環境選択的増殖阻害物質biakamide類の構造活性相関研究2015
- Author(s)
  ○石田良典，古徳直之，松本紘和，田畑奎太朗，小林資正
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪大谷大学
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15K07996
[Presentation] Synthetic study and target analysis of dictyoceratin-A and -C, hypoxia-selective growth inhibitors from marine sponge2015
- Author(s)
  Naoyuki Kotoku, Yuji Sumii, Takashi Kawachi, Akinori Fukuda, Masayoshi Arai and Motomasa Kobayashi
- Organizer
  PACIFICHEM 2015
- Place of Presentation
  ホノルル（米国）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] 栄養飢餓環境選択的がん細胞増殖阻害物質の探索2015
- Author(s)
  荒井雅吉，申多英，松本紘和，神谷謙太朗，久智也，古徳直之，小林資正
- Organizer
  日本生薬学会第62年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] 栄養飢餓環境選択的がん細胞増殖阻害物質の探索2015
- Author(s)
  荒井雅吉，○申多英，松本紘和，神谷謙太朗，久智也，古徳直之，小林資正
- Organizer
  日本生薬学会第62年会
- Place of Presentation
  長良川国際会議場
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-15K07996
[Presentation] Anti-dormant mycobacterial activity and action-mechanism of nybomycin produced by Streptomyces sp.2015
- Author(s)
  Kentaro Kamiya, Masayoshi Arai, Patamaporn Pruksakorn, Yuji Sumii, Naoyuki Kotoku, Chisu Han, Dayoung Shin and Motomasa Kobayashi
- Organizer
  The 9th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
- Place of Presentation
  ソウル（韓国）
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03114
[Presentation] 海綿由来環状デプシペプチドarenastatin Aの新規結合タンパク質の同定2015
- Author(s)
  ◯荒井雅吉，河内崇志，高市伸宏，馬田哲也，古徳直之，小林資正
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  神奈川県民ホール（神奈川県・横浜市）
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 実用的な医薬リード化合物の創製を指向した海洋天然物の合成化学研究2015
- Author(s)
  古徳直之
- Organizer
  日本生薬学会第62回年会
- Place of Presentation
  長良川国際会議場
- Year and Date
  2015-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-25750384
[Presentation] グルコース飢餓環境選択的がん細胞増殖阻害活性を有するポリケチドbiakamide類の全合成と構造活性相関2015
- Author(s)
  ○石田良典，古徳直之，松本紘和，荒井雅吉，小林資正
- Organizer
  第41回反応と合成の進歩シンポジウム
- Place of Presentation
  近畿大学
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-15K07996
[Presentation] 実用的な医薬リード化合物の創製を指向した海洋天然物の合成化学研究2015
- Author(s)
  古徳直之
- Organizer
  日本生薬学会第６２回年会
- Place of Presentation
  長良川国際会議場（岐阜県・岐阜市）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 栄養飢餓環境選択的がん細胞増殖阻害物質の探索2015
- Author(s)
  荒井雅吉，○申多英，松本紘和，神谷謙太朗，久智也，古徳直之，小林資正
- Organizer
  日本生薬学会第62年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-15H03114
[Presentation] 低栄養選択的増殖阻害物質fasciospyrinadinoneの全合成2015
- Author(s)
  古徳直之，松本紘和，◯久智也，戸田和成，荒井雅吉，小林資正
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪大谷大学（大阪府・富田林市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] Synthetic study and target analysis of dictyoceratin-A and -C, hypoxia-selective growth inhibitors from marine sponge.2015
- Author(s)
  ◯Naoyuki Kotoku, Yuji Sumii, Takashi Kawachi, Akinori Fukuda, Masayoshi Arai and Motomasa Kobayashi
- Organizer
  PACIFICHEM 2015
- Place of Presentation
  Hawaii (USA)
- Year and Date
  2015-12-14
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 低酸素環境選択的がん細胞増殖阻害物質dictyoceratin-Cの標的分子解析2015
- Author(s)
  ◯河内崇志，荒井雅吉，古徳直之，小林資正
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル（愛媛県・松山市）
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] グルコース飢餓環境選択的がん細胞増殖阻害活性を有するポリケチドbiakamide類の全合成と構造活性相関2015
- Author(s)
  石田良典，古徳直之，松本紘和，荒井雅吉，小林資正
- Organizer
  第41回反応と合成の進歩シンポジウム
- Place of Presentation
  近畿大学（大阪府東大阪市）
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] グルコース飢餓環境選択的がん細胞増殖阻害活性を有するポリケチドbiakamide類の全合成と構造活性相関2015
- Author(s)
  ◯石田良典，古徳直之，松本紘和，荒井雅吉，小林資正
- Organizer
  第41回反応と合成の進歩シンポジウム
- Place of Presentation
  近畿大学（大阪府・東大阪市）
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] Synthetic study and target analysis of dictyoceratin-A and -C, hypoxia-selective growth inhibitors from marine sponge.2015
- Author(s)
  Naoyuki Kotoku, Yuji Sumii, Takashi Kawachi, Akinori Fukuda, Masayoshi Arai and Motomasa Kobayashi
- Organizer
  PACIFICHEM 2015
- Place of Presentation
  ホノルル（米国）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03114
[Presentation] 海洋天然物furospinosulin-1を利用する新規がん細胞低酸素適応因子の創出2014
- Author(s)
  ◯河内崇志，荒井雅吉，古徳直之，小林資正
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  TKPガーデンシティ仙台（仙台）
- Year and Date
  2014-06-25
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] Cortistatin A アナログの効率的合成法の開発2014
- Author(s)
  古徳直之、○渋谷俊一、竹島亜季、角居雄太、伊藤葵、水野華奈子、小林資正
- Organizer
  第６４回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都薬科大学(京都府京都市）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25750384
[Presentation] グルコース飢餓環境選択的がん細胞増殖阻害作用を有する新規ポリケチド類の化学構造と生物活性2014
- Author(s)
  ◯古徳直之，戸田和成，荒井雅吉，石田良典，松本紘和，村岡　修，小林資正
- Organizer
  第56回天然有機化合物討論会
- Place of Presentation
  高知県立県民文化ホール（高知）
- Year and Date
  2014-10-15
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] Cortistatin A アナログ化合物の効率的合成法の開発2014
- Author(s)
  古徳直之、◯渋谷俊一、竹島亜季、角居雄太、伊藤葵、水野華奈子、小林資正
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都薬科大学（京都）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] 低酸素環境選択的細胞増殖阻害活性物質dictyoceratin-Cの合成研究2014
- Author(s)
  住井裕司、古徳直之、◯福田昭典、河内崇志、角居雄太、荒井雅吉、小林資正
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都薬科大学（京都）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26242074
[Presentation] 創薬を指向した海洋天然物のケミカルバイオロジー研究2013
- Author(s)
  古徳直之
- Organizer
  日本薬学会北海道支部第１回薬学の有機化学を考える会
- Place of Presentation
  北海道
- Invited
- Data Source
  KAKENHI-PROJECT-25750384
[Presentation] 海洋天然物cortistatin Aを基盤とする抗がんリード化合物の創製2013
- Author(s)
  古徳直之
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2013-03-30
- Invited
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 創薬を指向した海洋天然物のケミカルバイオロジー研究2013
- Author(s)
  古徳直之
- Organizer
  日本薬学会北海道支部第１回薬学の有機化学を考える会
- Place of Presentation
  北海道
- Invited
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] Furospinosulin-1由来の新規抗腫瘍活性リード化合物の合成と標的タンパク質解析2012
- Author(s)
  古徳直之
- Organizer
  第１０回次世代を担う有機化学シンポジウム
- Place of Presentation
  大阪大学銀杏会館
- Year and Date
  2012-05-12
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 血管新生阻害物質cortistatin A由来の抗腫瘍リード化合物の創製2012
- Author(s)
  古徳直之
- Organizer
  日本生薬学会　第５９回年会
- Place of Presentation
  かずさアカデミアパーク
- Year and Date
  2012-09-17
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 血管新生阻害物質cortistatin A由来の抗腫瘍リード化合物の創製2012
- Author(s)
  古徳直之
- Organizer
  日本生薬学会　第59回年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] 血管新生阻害物質cortistatin A由来の抗腫瘍リード化合物の創製研究2012
- Author(s)
  古徳直之
- Organizer
  第19回天然薬物の開発と応用シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] 海洋天然物cortistatin Aを基盤とする抗腫瘍活性リード化合物の創製2012
- Author(s)
  古徳直之
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] Cortistatin Aをモチーフとする抗腫瘍活性リード化合物の創製2012
- Author(s)
  古徳直之
- Organizer
  第６２回日本薬学会近畿支部総会・大会
- Place of Presentation
  武庫川女子大学薬学部
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] Cortistatin Aをモチーフとする抗腫瘍活性リード化合物の創製2012
- Author(s)
  古徳直之
- Organizer
  第62回日本薬学会近畿支部大会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] 血管新生阻害物質cortistatin A由来の抗腫瘍リード化合物の創製研究2012
- Author(s)
  古徳直之
- Organizer
  第１９回天然薬物の開発と応用シンポジウム
- Place of Presentation
  大阪大学会館
- Year and Date
  2012-11-02
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 血管新生阻害物質cortistatin A由来の抗がん剤リード化合物の創製研究2012
- Author(s)
  古徳直之
- Organizer
  日本がん分子標的治療学会第16回学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] 海洋天然物由来の抗がんリード化合物の創製と標的タンパク質解析2012
- Author(s)
  古徳直之
- Organizer
  「天然物ケミカルバイオロジー：分子標的と活性制御」第１回若手研究者ワークショップ
- Place of Presentation
  東京医科歯科大学
- Year and Date
  2012-06-16
- Invited
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 血管新生阻害物質cortistatin A由来の抗がん剤リード化合物の創製研究2012
- Author(s)
  古徳直之
- Organizer
  日本がん分子標的治療学会第１６回学術集会
- Place of Presentation
  北九州市　西日本総合展示場
- Year and Date
  2012-06-28
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 海洋天然物cortistatin Aを基盤とする抗腫瘍活性リード化合物の創製2012
- Author(s)
  古徳直之
- Organizer
  第３０回メディシナルケミストリーシンポジウム
- Place of Presentation
  タワーホール船堀
- Year and Date
  2012-11-28
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 海綿由来血管新生阻害物質cortistatin Aの全合成研究2011
- Author(s)
  住井裕司、古徳直之、小林資正, ら
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡(グランシップ静岡)
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] 海綿由来抗腫瘍性環状デプシペプチドarenastatin Aの作用機序解明を目指したプローブ分子の合成2011
- Author(s)
  高市伸宏、古徳直之、小林資正, ら
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡(グランシップ静岡)
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] 海洋天然物cortistatin A をモチーフとする新規抗がんリード化合物の創製2011
- Author(s)
  古徳　直之
- Organizer
  日本生薬学会第５８回年会
- Place of Presentation
  昭和大学（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] Synthetic Studies of Furospinosulin-1, A Hypoxia-Selective Growth Inhibitor From Marine Sponge2010
- Author(s)
  古徳直之、小林資正, ら
- Organizer
  The 13th International Symposium on Marine Natural Products
- Place of Presentation
  Hilton Phuket, Phuket (Thailand)
- Year and Date
  2010-10-19
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] 血管新生阻害物質cortistatin Aのアナログ化合物の設計と合成2010
- Author(s)
  古徳直之、林岡史、森本薫、住井裕司、小林資正
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] Cell-based assay基盤とする天然薬物由来の医薬シーズの探索2010
- Author(s)
  小林資正、古徳直之、芒井雅吉
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 低酸素環境選択的増殖阻害物質furospinosulin-1のアナログ化合物の合成と作用メカニズム解析2010
- Author(s)
  古徳直之、荒井雅吉、小林資正, ら
- Organizer
  第52回天然有機化合物討論会
- Place of Presentation
  静岡(グランシップ静岡)
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] 血管新生阻害物質cortistatin Aの合成研究2010
- Author(s)
  古徳直之、小林資正, ら
- Organizer
  第36回反応と合成の進歩シンポジウム
- Place of Presentation
  名古屋(ウイングあいち)
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] 低酸素環境選択的増殖阻害物質furospinosulin-1の構造活性相関2010
- Author(s)
  藤岡真一、古徳直之、小林資正, ら
- Organizer
  第60回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪(摂南大学薬学部)
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] ボロン酸基を捕捉補助基とする新規プローブ分子の合成と機能2010
- Author(s)
  郭修〓、古徳直之、小林資正, ら
- Organizer
  第60回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪(摂南大学薬学部)
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] CORTISTATINS, NOVEL ANTI-ANGIOGENIC STEROIDAL ALKALOIDS, FROM MARINE SPONGE2010
- Author(s)
  古徳直之、小林資正, ら
- Organizer
  The 13th International Symposium on Marine Natural Products
- Place of Presentation
  Hilton Phuket, Phuket (Thailand)
- Year and Date
  2010-10-18
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] Synthetic Studies of Cortistatin A, An Anti-Angiogenic Steroidal Alkaloid From Marine Sponge2010
- Author(s)
  古徳直之、小林資正, ら
- Organizer
  The 13th International Symposium on Marine Natural Products
- Place of Presentation
  Hilton Phuket, Phuket (Thailand)
- Year and Date
  2010-10-18
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] 生薬polygala senega由来サポニンsenegin類の血管新生阻害作用2009
- Author(s)
  荒井雅吉、林亜紗実、石田俊介、河内崇志、惣坊真理、古徳直之、小林資正
- Organizer
  第3回食品薬学シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 生薬Polygala senega由来サポニンsenegin類の血管新生阻害作用2009
- Author(s)
  荒井雅吉、林亜紗実、石田俊介、河内崇志、惣坊真理、古徳直之、小林資正
- Organizer
  日本生薬学会第56回年会
- Place of Presentation
  京都
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 海洋由来真菌が産生する新規アミリポペプチドtrichoderin類の抗結核活性2009
- Author(s)
  Patamaporn Pruksakorn、荒井雅吉、古徳直之、小林資正
- Organizer
  第59回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] Anti-angiogenic marine natural products2009
- Author(s)
  古徳直之
- Organizer
  Frontiers in Medicinal Chemistry
- Place of Presentation
  ドイツ
- Year and Date
  2009-03-17
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 海洋生物成分からの新しい抗がん剤シーズ探索2009
- Author(s)
  荒井雅吉、古徳直之、小林資正
- Organizer
  近畿大学薬学総合研究所・大学院薬学研究科、文部科学省私立大学学術高度化推進事業、ハイテク・リサーチ・センター整備事業第5回シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2009-06-27
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] Anti-angiogenic marine natural products2009
- Author(s)
  Kotoku, N.
- Organizer
  Frontiers in Medicinal Chemistry
- Place of Presentation
  ハイデルベルク大学
- Year and Date
  2009-03-17
- Data Source
  KAKENHI-PROJECT-19790014
[Presentation] インドネシア産海綿由来furospinosulin-1の低酸素環境特異的がん細胞増殖阻害2009
- Author(s)
  荒井雅吉、河内崇志、古徳直之、住井裕司、藤岡真一、小林資正
- Organizer
  第51回天然有機化合物討論会
- Place of Presentation
  名古屋
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] Search for Medicinal Seed from Marine Organisms.2009
- Author(s)
  Motomasa Kobayashi, Naoyuki Kotoku, Masayoshi Arai
- Organizer
  The 25th Naito Conference on Chemical Biology [II]
- Place of Presentation
  北海道
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] Hypoxia-selective growth inhibitor, furospinosulin-1, from Indonesian marine sponge.2009
- Author(s)
  Masayoshi Arai, Takashi Kawachi, Naoyuki Kotoku, Yuji Sumii, Motomasa Kobayashi
- Organizer
  The 25th Naito Conference on Chemical Biology [II]
- Place of Presentation
  北海道
- Year and Date
  2009-09-09
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 海洋由来真菌が産生する新規アミリポペプチドtrichoderin類の抗結核活性とその作用メカニズム2009
- Author(s)
  荒井雅吉、Patamaporn Pruksakorn、古徳直之、小林資正
- Organizer
  日本生薬学会第56回年会
- Place of Presentation
  京都
- Year and Date
  2009-10-04
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 低酸素環境選択的細胞増殖阻害物質furospinosulin-1および活性アナログ化合物の合成研究2009
- Author(s)
  住井裕司、古徳直之、藤岡真一、河内崇志、荒井雅吉、小林資正
- Organizer
  第59回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 海綿由来血管新生阻害物質cortistatin AのA環部分の合成2008
- Author(s)
  古徳直之、平川陽一、林剛史、小林資正
- Organizer
  日本薬学会第128年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19790014
[Presentation] 海綿由来の血管新生阻害物質をシーズとする活性リード化合物の合成2008
- Author(s)
  古徳直之
- Organizer
  第12回がん分子標的治療研究会総会
- Place of Presentation
  学術総合センター
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-16073212
[Presentation] 海綿由来の血管新生阻害物質globostellatic acid X methyl esterのモデル化合物の合成と活性評価2008
- Author(s)
  古徳直之
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸薬科大学
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-16073212
[Presentation] 海綿由来の血管新生阻害物質をシーズとする活性リード化合物の合成2008
- Author(s)
  古徳直之
- Organizer
  第12回がん分子標的治療研究会総会
- Place of Presentation
  学術総合センター
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-19790014
[Presentation] 海綿由来の血管新生阻害物質globostenatic acid X methyl esterのモデル化合物の合成と活性評価2008
- Author(s)
  古徳直之
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸薬科大学
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-19790014
[Presentation] 海綿由来血管新生阻害物質globostellatic acid X methyl ester の構造活性相関2008
- Author(s)
  古徳直之
- Organizer
  第17回天然薬物の開発と応用シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 海綿由来血管新生阻害物質globostellatic acid X mithyl esterの構造活性相関2008
- Author(s)
  古徳直之
- Organizer
  第17回天然薬物の開発と応用シンポジウム
- Place of Presentation
  九州大学医学部百年講堂
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-19790014
[Presentation] 海綿由来血管新生阻害物質globostellatic acid X methyl esterの構造活性相関2008
- Author(s)
  古徳直之
- Organizer
  第17回天然薬物の開発と応用シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 海綿由来の血管新生阻害物質をシーズとする活性リード化合物の合成2008
- Author(s)
  古徳直之
- Organizer
  第12回がん分子標的治療研究会総会
- Place of Presentation
  学術総合センター
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 海綿由来血管新生阻害物質globostellatic acid X methyl esterの構造活性相関2008
- Author(s)
  古徳直之
- Organizer
  第17回天然薬物の開発と応用シンポジウム
- Place of Presentation
  九州大学医学部百年講堂
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 海綿由来血管新生阻害物質globostellatic acid X methyl esterの構造活性相関2008
- Author(s)
  古徳直之
- Organizer
  第17回天然薬物の開発と応用シンポジウム
- Place of Presentation
  九州大学医学部百年講堂
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-16073212
[Presentation] 海綿由来の血管新生阻害物質globostellatic acid X methyl esterのモデル化合物の合成と活性評価2008
- Author(s)
  古徳直之
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸薬科大学
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 海綿由来の血管新生阻害物質globostellatic acid X methyl esterのモデル化合物の合成と活性評価2008
- Author(s)
  古徳直之、玉田尚、林亜紗実、小林資正
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸薬科大学
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-19790014
[Presentation] 海綿由来血管新生阻害物質globostellatic acid X methyl esterの構造活性相関2008
- Author(s)
  古徳直之、玉田尚、林亜紗実、小林資正
- Organizer
  第17回天然薬物の開発と応用シンポジウム
- Place of Presentation
  九州大学医学部百年講堂
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-19790014
[Presentation] 海綿由来の血管新生阻害物質bastadin 6の標的タンパク質の探索2007
- Author(s)
  古徳直之、辻家崇維、荒井雅吉、小林資正
- Organizer
  第57回日本薬学会近畿支部大会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-19790014
[Presentation] 血管新生阻害物質cortistatin AのA環フラグメントの構築2007
- Author(s)
  古徳直之、平川陽一、小林資正
- Organizer
  第57回日本薬学会近畿支部大会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-19790014
[Presentation] 海綿由来の血管新生阻害物質bastadin 6 の標的タンパク質の探索2007
- Author(s)
  古徳直之
- Organizer
  第57回日本薬学会近畿支部大会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-19790014
[Presentation] 海綿由来の血管新生阻害物質bastadin 6の標的タンパク質の探索2007
- Author(s)
  古徳直之
- Organizer
  第57回日本薬学会近畿支部大会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-16073212
[Presentation] 海綿由来の血管新生阻害物質bastadin 6の標的タンパク質の探索2007
- Author(s)
  古徳直之
- Organizer
  第57回日本薬学会近畿支部大会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 海綿由来の血管新生阻害物質cortistatin類の構造活性相関と作用メカニズムの解析2007
- Author(s)
  古徳直之
- Organizer
  第49回天然有機化合物討論会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-16073212
[Presentation] 海綿由来の血管新生阻害物質cortistatin類の構造活性相関と作用メカニズムの解析2007
- Author(s)
  古徳直之、渡部康雄、青木俊二、住井裕司、田辺大樹、荒井雅吉、小林資正
- Organizer
  第49回天然有機化合物討論会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-19790014
[Presentation] 海綿由来の血管新生阻害物質cortistatin類の構造活性相関と作用メカニズムの解析2007
- Author(s)
  古徳直之
- Organizer
  第49回天然有機化合物討論会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] 海綿由来の血管新生阻害物質cortistatin類の構造活性相関と作用メカニズムの解析2007
- Author(s)
  古徳直之
- Organizer
  第50回天然有機化合物討論会
- Place of Presentation
  仙台
- Year and Date
  2007-09-25
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] Synthetic studies of bastadin 6, an anti-angiogenic substance from marine sponge.2006
- Author(s)
  古徳直之
- Organizer
  IUPAC International Conference on Biodiversity and Natural Products
- Place of Presentation
  京都
- Year and Date
  2006-07-24
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] Synthetic studies of bastadin 6, an anti-angiogenic substance from marine sponge2006
- Author(s)
  古徳直之
- Organizer
  IUPAC International Conference on Biodiversity and Natural Products
- Place of Presentation
  京都
- Year and Date
  2006-07-24
- Data Source
  KAKENHI-PROJECT-18201042
[Presentation] プローブ分子を用いたcortistatin A の標的分子の解析研究
- Author(s)
  伊藤葵，古徳直之，住井裕司，角居雄太，小林資正
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学等（熊本市）
- Year and Date
  2014-03-27 – 2014-03-30
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] 低酸素環境選択的がん細胞増殖阻害物質furospinosulin-1のin vivo評価
- Author(s)
  荒井雅吉，河内崇志，古徳直之，遠藤洋子，井上正宏，小林資正
- Organizer
  日本生薬学会第60回年会
- Place of Presentation
  北海道医療大学（北海道）
- Year and Date
  2013-09-07 – 2013-09-08
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] 海洋天然物furospinosulin-1を利用する新規がん細胞低酸素適応因子の創出
- Author(s)
  河内崇志、荒井雅吉、古徳直之、小林資正
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台市情報・産業プラザ等（仙台市）
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 海洋由来放線菌が産生するnybomycinの潜在性結核菌に対する抗菌活性とその作用メカニズム
- Author(s)
  荒井雅吉、神谷謙太朗、住井裕司、申多英、 Patamaporn Pruksakorn、韓智秀、古徳直之、小林資正
- Organizer
  日本生薬学会第６１回年会
- Place of Presentation
  福岡大学（福岡市）
- Year and Date
  2014-09-13 – 2014-09-14
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 低酸素環境選択的がん細胞増殖阻害物質furospinosulin-1の標的分子の解明
- Author(s)
  荒井雅吉，河内崇志，中田千晶，古徳直之，小林資正
- Organizer
  第55回天然有機化合物討論会
- Place of Presentation
  同志社大学（京都市）
- Year and Date
  2013-09-18 – 2013-09-19
- Data Source
  KAKENHI-PROJECT-22241053
[Presentation] Target identification of anti-tumor depsi-peptide, arenastatin A, by the method of phage display
- Author(s)
  Masayoshi Arai, Naoyuki Kotoku, Motomasa Kobayashi
- Organizer
  新学術領域研究「天然物ケミカルバイオロジー～分子標的と活性制御～」第3回国際シンポジウム（第7回公開シンポジウム）
- Place of Presentation
  千里ライフサイエンスセンター（大阪府）
- Year and Date
  2014-10-28 – 2014-10-29
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] Phage Display法を利用した抗腫瘍性物質arenastatin Aの標的分子解析
- Author(s)
  河内崇志、荒井雅吉、馬田哲也、古徳直之、高市伸宏、小林資正
- Organizer
  第２０回天然薬物の開発と応用シンポジウム
- Place of Presentation
  東京大学（東京都）
- Year and Date
  2014-11-05 – 2014-11-06
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] ゲノムDNAライブラリーを利用する抗菌物質の標的分子解析 - 潜在性結核菌に有効な海綿由来テトラミン酸melophlin類の標的分子解析 -
- Author(s)
  荒井雅吉、古徳直之、小林資正
- Organizer
  新学術領域研究「天然物ケミカルバイオロジー～分子標的と活性制御～」第6回公開シンポジウム
- Place of Presentation
  名古屋大学（名古屋市）
- Year and Date
  2014-05-28 – 2014-05-29
- Data Source
  KAKENHI-PLANNED-23102005
[Presentation] 海洋天然物cortistatin Aを基盤とする抗腫瘍活性リード化合物の創製
- Author(s)
  古徳直之
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  アステールプラザ（広島市）
- Year and Date
  2013-11-20 – 2013-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-22241053

1. KOBAYASHI Motomasa (40116033)

# of Collaborated Projects: 7 results

# of Collaborated Products: 82 results
2. ARAI Masayoshi (80311231)

# of Collaborated Projects: 7 results

# of Collaborated Products: 69 results
3. AOKI Shunji (60252699)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. Ito Akihiko (80273647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 浜田芳男 (70424968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 住井裕司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kotoku Naoyuki 古徳 直之

KOTOKU Naoyuki 古徳 直之

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海洋天然物を起点とする膵臓ガン選択的増殖阻害剤の創製と薬剤耐性メカニズム解明Principal Investigator

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Mechanistic studies of tumor cell growth using marine natural product and its application for anti-tumor drug discoveryPrincipal Investigator

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Medicinal chemistry study of bioactive marine natural products targeting tumor microenvironmentPrincipal Investigator

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Target identification of cortistatin A and development of anti-cancer drug leadPrincipal Investigator

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Synthetic studies of marine natural products having anti-angiogenic activitiesPrincipal Investigator

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血管新生を標的とする新規抗がんリード化合物の創製Principal Investigator

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Kotoku Naoyuki 古徳直之

KOTOKU Naoyuki 古徳直之