Hashiguchi Masaaki 橋口昌章

… Alternative Names

橋口昌章ハシグチマサアキ

HASHIGUCHI Masaaki 橋口昌章

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Researcher Number	20372443
Other IDs
External Links
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 臨床医科学研究分野, 主席研究員
Affiliation (based on the past Project Information) *help	2025: 東京大学, 大学院農学生命科学研究科(農学部), 特任研究員 2022 – 2023: 日本医科大学, 先端医学研究所, 准教授 2012 – 2020: 獨協医科大学, 医学部, 准教授 2011: 獨協医科大学, 医学部, 免疫学講座 2010 – 2011: 獨協医科大学, 医学部, 助教 … More 2010: 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 2009: Tokyo Medical and Dental University, 医歯学総合研究科, 助教 2007 – 2008: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 2006: 東京医科歯科大学, 大学院医歯学総合研究科, 助手 2004 – 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 38050:Food sciences-related / Pathobiological dentistry/Dental radiology / Food science Except Principal Investigator Pathobiological dentistry/Dental radiology / Biological Sciences / 病態科学系歯学(含放射線系歯学) / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator IgA / パイエル板 / IL-21 / IL-22 / 自然リンパ球 / アレルギー / 補助シグナル / 炎症 / 感染 / 免疫 … More / B細胞 / Tfh / 形質細胞 / IgG1 / IgE / BAFF / APRIL / 腸内細菌 / mucosal immunity / co-signal molecule / keratinocyte / 補助刺激分子 / 粘膜免疫 / 補助シグナル分子 / 角化上皮細胞 / マーキング / GFP / 好酸球 / IL-33 / IL-5 / Tlt2 / 抗腫瘍免疫 / TLT2 / B7-H3 / ヒト免疫応答 / 破骨細胞 / T細胞 … More Except Principal Investigator 免疫 / T細胞 / 樹状細胞 / 免疫制御 / 補助シグナル分子 / 歯学 / 歯髄 / RNA干渉 / 炎症 / 口腔粘膜 / 自己免疫 / 免疫学 / 制御性T細胞 / T lymphocytes / Dendritic cells / Oral diseases / Costimulatory molecules / Cancer / Infectious diseases / Dentistry / Immunology / 細胞間相互作用 / 破骨細胞 / 補助シグナル / 骨吸収 / 歯髄炎 / 粘膜上皮細胞 / 口腔粘膜疾患 / 口腔疾患 / 癌 / 感染症 / HIF-1α / B細胞分化 / 解糖系 / HIF-1a / 歯周疾患 / イメージング / 免疫療法 / 感染 / 細胞療法 / 免疫回避機構 / がん免疫 / CD86 / 接触性過敏症 / RNAi / 抑制シグナル分子 / B7 / 免疫細胞 / 抑制分子 / 免疫応答 / 免疫寛容 / ホメオスターシス / B7ファミリー Less

パイエル板自然リンパ球およびB細胞による腸内細菌制御Principal Investigator
- Principal Investigator
  
  橋口昌章
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  The University of Tokyo
パイエル板Ｔｆｈによる抗体産生制御：対立遺伝子排除の破綻とアレルギーの抑制Principal Investigator
- Principal Investigator
  
  橋口昌章
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Nippon Medical School
Does IL-21 produced in Peyer's patch regulate the affinity of IgA and food allergy?Principal Investigator
- Principal Investigator
  
  Hashiguchi Masaaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Dokkyo Medical University
Peyer's patch immune cells regulates intestinal bacteria: basic research for the manipulation of intestinal bacteria by foodsPrincipal Investigator
- Principal Investigator
  
  HASHIGUCHI Masaaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Dokkyo Medical University
Functional study of IL-5-producing cells in food allergy using GFP marking systemPrincipal Investigator
- Principal Investigator
  
  MASAAKI Hashiguchi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Dokkyo Medical University
Regulatory roles of HIF-1a and glycolysis in autoimmunity
- Principal Investigator
  
  KOBATA Tetsuji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Dokkyo Medical University
T細胞に依存しない新たな補助シグナル分子機能の解明
- Principal Investigator
  
  東みゆき
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Immune regulation of oral disease by co-signal molecule B7-H3 and the novel receptor.Principal Investigator
- Principal Investigator
  
  HASHIGUCHI Masaaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Dokkyo Medical University
  Tokyo Medical and Dental University
Analyses of Regulatory Mechanisms in Oral Immune Responses and Development of a New Immunotherapy Targeting Dendritic Cells
- Principal Investigator
  
  AZUMA Miyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical and Dental University
機能T細胞のマルチイメージング化による歯周疾患の免疫病態解析手法の確立
- Principal Investigator
  
  東みゆき
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical and Dental University
Triggering receptor expressed on myeloid cell-like transcript 2(TLT-2)is a counter-receptor for B7-H3 and enhances T cell responsesPrincipal Investigator
- Principal Investigator
  
  HASHIGUCHI Masaaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical and Dental University
周囲環境により変化する多機能性ミエロイド細胞の癌治療への応用
- Principal Investigator
  
  東みゆき
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
RNA干渉による口腔粘膜の炎症制御に関する研究
- Principal Investigator
  
  東みゆき
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical and Dental University
The Regulation of Oral Mucosa Immunity by Immune Co-inhibitory MoleculesPrincipal Investigator
- Principal Investigator
  
  HASHIGUCHI Masaaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical and Dental University
ホメオスターシスと自己寛容に関わるT細胞補助刺激分子の機能解析とその人為的制御
- Principal Investigator
  
  AZUMA Miyuki
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Functional analysis of costimulatory molecules in oral diseases and their intervention for clinical application
- Principal Investigator
  
  AZUMA Miyuki
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Tokyo Medical and Dental University

[Journal Article] IL-21 and IL-5 coordinately induce surface IgA+ cells2020
- Author(s)
  Hashiguchi Masaaki、Kashiwakura Yuji、Kanno Yumiko、Kojima Hidefumi、Kobata Tetsuji
- Journal Title
  
  Immunology Letters
  
  Volume: 224 Pages: 21-27
- DOI
  10.1016/j.imlet.2020.05.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05478
[Journal Article] Peyer’s patches contain abundant isotype-switched B cells with activated phenotypes and are inductive sites for T-independent anti-DNA IgA2019
- Author(s)
  Hashiguchi, M., Kashiwakura, Y., Kojima, H., Kanno, Y., Kobata, T.
- Journal Title
  
  Immunol. Lett.
  
  Volume: 211 Pages: 53-59
- DOI
  10.1016/j.imlet.2019.05.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05478
[Journal Article] Tumor necrosis factor superfamily member (TNFSF) 13 (APRIL) and TNFSF13B (BAFF) downregulate homeostatic immunoglobulin production in the intestines2018
- Author(s)
  Hashiguchi, M., Kashiwakura, Y., Kanno, Y., Kojima, H., Kobata, T.
- Journal Title
  
  Cell. Immunol.
  
  Volume: 323 Pages: 41-48
- DOI
  10.1016/j.cellimm.2017.10.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07438
[Journal Article] IL-33 activates eosinophils of visceral adipose tissue both directly and via innate lymphoid cells2015
- Author(s)
  Hashiguchi, M., Kashiwakura, Y., Kojima, H., Kobayashi, A., Kanno, Y., Kobata, T.
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 45 Issue: 3 Pages: 876-885
- DOI
  10.1002/eji.201444969
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24580196
[Journal Article] CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied with down regulation of Bim2013
- Author(s)
  Kashiwakura Y, Sakurai D, Kanno Y, Hashiguchi M, Kobayashi A, Kurosu A, Tokudome S, Kobata T, Kojima H.
- Journal Title
  
  Immunology
  
  Volume: 139 Issue: 1 Pages: 48-60
- DOI
  10.1111/imm.12054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591454
[Journal Article] Antibodies against B7-DC with differential binding properties exert opposite effects2012
- Author(s)
  Ritprajak P, Hashiguchi M, Akiba H, Yagita H, Okumura K, Azuma M
- Journal Title
  
  Hybridoma
  
  Volume: 31 Issue: 1 Pages: 40-47
- DOI
  10.1089/hyb.2011.0087
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021016, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23249082, KAKENHI-PROJECT-23390260
[Journal Article] Human B7-H3 binds to Triggering receptor expressed on myeloid cell-like transcript 2(TLT-2) and enhances T cell responses. Open J2012
- Author(s)
  M. Hashiguchi, Y. Inamochi, S. Nagai, S., N. Otsuki, P. Jinhua, H. Kobori, Y. Kanno, T. Kobata, M. Azuma
- Journal Title
  
  Immunol. Peer-reviewed
  
  Volume: 2 Issue: 01 Pages: 9-16
- DOI
  10.4236/oji.2012.21002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592385, KAKENHI-PUBLICLY-22021016, KAKENHI-PROJECT-23249082
[Journal Article] B7-H1 overexpression regulates epithelial-mesenchymal transition and accelerates carcinogenesis in skin.2011
- Author(s)
  Cao Y, Zhang L, Kamimura Y, Ritprajak P, Hashiguchi M, Hirose S, Azuma M
- Journal Title
  
  Cancer Res. 71(4)
  
  Pages: 1235-1243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249075
[Journal Article] B7-H1 overexpression regulates epithelial-mesenchymal transition and accelerates carcinogenesis in skin2011
- Author(s)
  Cao Y, Zhang L, Kamimura Y, Ritprajak P, Hashiguchi M, Hirose S, Azuma M
- Journal Title
  
  Cancer Res
  
  Volume: 71 Issue: 4 Pages: 1235-43
- DOI
  10.1158/0008-5472.can-10-2217
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021016, KAKENHI-PROJECT-22791809, KAKENHI-PROJECT-23249082
[Journal Article] Immunoregulatory molecules B7-H1 (CD274) contributes to skin carcinogenesis2011
- Author(s)
  Cao Y, Zhang L, Ritprajak P, Tsushima F, Youngnak-Piboonratanakit P, Kamimura Y, Hashiguchi M, Azuma M
- Journal Title
  
  Cancer Res
  
  Volume: 71 Issue: 14 Pages: 4737-4741
- DOI
  10.1158/0008-5472.can-11-0527
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021016, KAKENHI-PROJECT-22791809, KAKENHI-PROJECT-23249082
[Journal Article] Topical application of siRNA targeting cutaneous dendritic cells in allergic skin disease.2010
- Author(s)
  Azuma M, Ritprajak P, Hashiguchi M
- Journal Title
  
  Methods Mol Biol 623
  
  Pages: 373-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249075
[Journal Article] Enhancement of effector CD8+ T cell function by tumour-associated B7-H3 and modulation of its counter receptor triggering receptor expressed on myeloid cell-like transcripts 2 (TLT-2) at tumor sites.2010
- Author(s)
  Kobori H, Hashiguchi M, Piao J, Kato M, Ritprajak P, Azuma M
- Journal Title
  
  Immunology 130(3)
  
  Pages: 363-373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249075
[Journal Article] Keratinocytes-associetd B7-H1 directly regulated cutaneous effector CD8+ T cell responses2010
- Author(s)
  Ritprajak P, Hashiguchi M, Azuma M, et al.
- Journal Title
  
  J.Immunol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249075
[Journal Article] Enhancement of effector CD8^+T cell function by tumor-associated B7-H3 and modulation of its counter receptor triggering receptor expressed on myeloid cell-like transcript 2(TLT-2) at tumor sites2010
- Author(s)
  H. Kobori, M. Hashiguchi, J. Piao, M. Kato, P. Ritprajak, M. Azuma
- Journal Title
  
  Immunology Peer-reviewed
  
  Volume: 130 Issue: 3 Pages: 363-373
- DOI
  10.1111/j.1365-2567.2009.03236.x
- Data Source
  KAKENHI-PROJECT-21592385
[Journal Article] Enhancement of effector CD8^+ T cell function by tumor-associated B7-H3 and modulation of its counter receptor triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) at tumor sites2010
- Author(s)
  H.Kobori, M.Hashiguchi, J.Piao, M.Kato, P.Ritprajak, M.Azuma
- Journal Title
  
  Immunology 130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592385
[Journal Article] Keratinocytes-associated B7-H1 directly regulates cutaneous effector CD8+ T cell responses.2010
- Author(s)
  itprajak P, Hashiguchi M, Tsushima F, Chalermsarp N, Azuma M
- Journal Title
  
  J.Immunol. 184
  
  Pages: 4818-4925
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249075
[Journal Article] Possible involvement of soluble B7-H4 in T-cell-mediated inflammatory immune responses.2009
- Author(s)
  Kamimura Y, kobori H, Piao J, Hashiguchi M, Matsumoto K, Horose S, Azuma M
- Journal Title
  
  Biochem Biophys Res Commun 389
  
  Pages: 349-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249075
[Journal Article] Enhancement of T cell-mediated anti-tumor immunity via the ectopically expressed glucocruticoid-induced tumor necrosis factor receptor-related receptor ligand on tumors.2009
- Author(s)
  Piao J, Kamimura Y, Iwai H, Cao Y, Kikuchi K, Hashiguchi M, Masunaga T, Jiang H, Tamura K, Sakaguchi S. Azuma M
- Journal Title
  
  Immunology 127
  
  Pages: 489-499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249075
[Journal Article] The Glucocorticoid-induced TNFR-related protein (GITR)-GITR ligand pathway acts as a mediator of cutaneous dendritic cell migration and promotes T-cell mediated acquired immunity.2009
- Author(s)
  Kamimura Y, Iwai H, Piao J, Hashiguchi M, Azuma M
- Journal Title
  
  J Immunol 182
  
  Pages: 2708-2716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249075
[Journal Article] GITR ligand-costimulation activates effector and regulatory functions of CD4+ T cells.2008
- Author(s)
  Igarashi H, Cao Y, Iwai H, Piao J, Kamimura Y, Hashiguchi M, Amagasa T. Azuma M
- Journal Title
  
  Biochem Biophys Res Commun 369
  
  Pages: 1134-1138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249075
[Journal Article] Topical application of cream-emulsified CD86 siRNA ameliorates allerg ic skin disease by targeting cutaneous dendritic cells.2008
- Author(s)
  Ritprajak P, Hashiguchi M, Azuma M
- Journal Title
  
  Mol Ther 16(7)
  
  Pages: 1323-1330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249075
[Journal Article] Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses2008
- Author(s)
  Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Kozono, H., Azuma, M.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 105
  
  Pages: 10495-10500
- Data Source
  KAKENHI-PROJECT-19592168
[Journal Article] Trigerring receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses.2008
- Author(s)
  Hashiguchi M, Kobori H, Ritprajak P, Kamimura Y, Kozono H, Azuma M
- Journal Title
  
  Proc.Nathl.Acad.Sci.USA 105
  
  Pages: 10495-10500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249075
[Journal Article] Trigerring receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses2008
- Author(s)
  Hashiguchi M, Azuma M, Kobori H, et al.
- Journal Title
  
  Proc. Nathl. Acad. Sci. USA 105
  
  Pages: 10495-500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249075
[Journal Article] Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2)is acounter-receptor for B7-H3 and enhances T cell responses2008
- Author(s)
  Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Kozono, H., Azuma, M.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 10495-10500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592168
[Journal Article] B7ファミリーと免疫応答の制御2004
- Author(s)
  橋口昌章, 東みゆき
- Journal Title
  
  臨床免疫 42
  
  Pages: 85-89
- NAID
  40006351220
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591884
[Journal Article] Mini-review; Immunoregulatory molecules B7-H1 (CD274) contributes to skin carcinogenesis.
- Author(s)
  Cao Y, Zhang L, Ritprajak P, Tsushima F, Youngnak-Piboonratanakit P, Kamimura Y, Hashiguchi M, Azuma M
- Journal Title
  
  Cancer Res. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Interleukin 21 commits IgG1+ cells not to undergo class switch to IgE but to differentiate into plasmablasts2024
- Author(s)
  Masaaki Hashiguchi, Yoshiko Iwai
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K05481
[Presentation] RORalpha is crucial for the survival of IgA+ plasma cells but not B220+ IgA+ cells2019
- Author(s)
  Hashiguchi, M., Kashiwakura, Y., Kanno, Y., Kojima, H., Kobata, T.
- Organizer
  第48回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K05478
[Presentation] IL-21 and CD4+ T cells are required for Peyer’s patch germinal center formation but not for intestinal IgA in homeostatic condition2018
- Author(s)
  Hashiguchi, M., Kashiwakura, Y., Kanno, Y., Kojima, H., Kobata, T.
- Organizer
  第47回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K05478
[Presentation] Tumor necrosis factor superfamily member (TNFSF) 13, APRIL and TNFSF13B, BAFF downregulate homeostatic immunoglobulin production in intestines2017
- Author(s)
  Hashiguchi, M., Kashiwakura, Y., Kojima, H., Kanno, Y., Kobata, T.
- Organizer
  第46回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K07438
[Presentation] Differences in specificity and production between IgA and IgG in Peyer’s patches2016
- Author(s)
  Masaaki Hashiguchi, Yuji Kashiwakura, Hidefumi Kojima, Yumiko Kanno, Tetsuji Kobata
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター (沖縄県　宜野湾市)
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K07438
[Presentation] Peyer’s patch innate lymphoid cells regulate commensal bacteria expansion2016
- Author(s)
  Masaaki Hashiguchi, Ayano Kobayashi, Yuji Kashiwakura, Hidefumi Kojima, Yumiko Kanno, Tetsuji Kobata
- Organizer
  International Congress of Immunology 2016
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07438
[Presentation] Peyer’s patch innate lymphoid cells regulate commensal bacteria expansion2015
- Author(s)
  Hashiguchi Masaaki, Kashiwakura Yuji, Kojima Hidefumi, Kanno Yumiko, Kobata Tetsuji
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-15K07438
[Presentation] Cellular metabolism of CD4+ CD25+ regulatory T cells is distinct from that of CD4+ CD25- conventional T cells2014
- Author(s)
  Kojima H, Kanno Y, Kashiwakura Y, Hashiguchi M, Kobata T
- Organizer
  第４3回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] Glycolysis, that impacts on bone marrow B cell development, dose not have a decisive influence on peripheral B cell differentiation2014
- Author(s)
  Kanno Y, Kashiwakura T, Hashiguchi M, Kobata T, Kojima H
- Organizer
  第４3回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-11
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] Dual activation pathways of visceral adipose tissue eosinophils by interleukin-33 in vivo: innate lymphoid cell-mediated and direct actions2014
- Author(s)
  Hashiguchi Masaaki, Kashiwakura Yuji, Kojima Hidefumi, Kanno Yumiko, Kobata Tetsuji
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-11
- Data Source
  KAKENHI-PROJECT-24580196
[Presentation] CD2 stimulation upregulates Foxp3 in murine peripheral regulatory T cells2014
- Author(s)
  Kashiwakura Y, Kanno Y, Hashiguchi M, Kobata T, Kojima H
- Organizer
  第４3回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] TCR-independent CD4+CD25+ regulatory T cell activation during immune responses2013
- Author(s)
  Kojima H, Kashiwakura Y, Hashiguchi M, Kobata T.
- Organizer
  15th international Congress of Immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied by downregulation of Bim2013
- Author(s)
  Kashiwakura Y, Sakurai D, Kanno Y, Hashiguchi M, Kobayashi A, Kurosu A, Tokudome S, Kobata T, Kojima H.
- Organizer
  15th international Congress of Immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] HIF-1α is regulated by IL-7 in pro-B cells during B cell development.2013
- Author(s)
  Kanno Y, Kashiwakura T, Hashiguchi M, Kobata T, Kojima H.
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] Cytokine-dependent CD4+CD25+ regulatory T cell activation during immune responses2013
- Author(s)
  Kojima H, Kanno Y, Kashiwakura Y, Hashiguchi M, Kobata T.
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied by down regulation of Bim2013
- Author(s)
  Kashiwakura Y, Sakurai D., Kanno Y, Hashiguchi M, Kobata T, Kojima H.
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] The GITR-GITR ligand pathway acts as a mediator of cutaneous DC migration and promotes T cell-mediated immunity.2010
- Author(s)
  Kamimura Y, Piao J, Hashiguchi M, Azuma M
- Organizer
  14th ICI
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Triggering receptor expressed on myeloid cells-like transcript 2(TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses in mice and humans.2010
- Author(s)
  Hashiguchi M, Kobori H, Ritprajak P, Kamimura Y, Azuma M
- Organizer
  14th ICI
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Triggering receptor expressed on myeloid cells-liketranscript 2(TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses in mice and humans2010
- Author(s)
  Hashiguchi M.
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Keratinocyte-associated B7-H1 directly regulates cutaneous effector CD8+ T cell responses.2010
- Author(s)
  Ritprajak P, Hashiguchi M, Azuma M
- Organizer
  14th ICI
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Triggering receptor expressed on myeloid cells-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses in mice and humans.2010
- Author(s)
  Hashiguchi M, Kobori H, Ritprajak P, Kamimura Y, Azuma M
- Organizer
  14th ICI
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] B7-H1 on epidermal keratinocytes downregulates skin inflammation, but promotes squamous cell carcinoma formation.2010
- Author(s)
  Cao Y, Zhang L, Ritprajak P, Hashiguchi M, Hase H, Azuma M
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Enhancement of effector CD8^+ T cell function by tumor-associated B7-H3 and modulation of its counter receptor triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) at tumor sites.2010
- Author(s)
  Kobori H, Hashiguchi M, Azuma M
- Organizer
  14^<th> ICI
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Antibodies against B7-DC with differential binding properties exert opposite effects : Implication of dual functions in PD -1 and B7-DC interactions.2010
- Author(s)
  Azuma M, Ritprajak P, Akiba H, Yagita H, Okumura K, Hashiguchi M
- Organizer
  14th ICI
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Overexpression of B7-H1 on epidermal keratinocytes promotes squamous cell carcinoma formation.2010
- Author(s)
  Cao Y, Zhang L, Ritprajak P, Hashiguchi M, Azuma M
- Organizer
  14^<th> ICI
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Triggering receptor expressed on myeloid cells-like transcript 2 (TLT-2) is a counter-receptor for B7-H32010
- Author(s)
  M.Hashiguchi
- Organizer
  The 14th International Congress of Immunology
- Place of Presentation
  神戸
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-21592385
[Presentation] Triggering receptor expressed on myeloid cells-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses in mice and humans2010
- Author(s)
  Hashiguchi M.
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PUBLICLY-22021016
[Presentation] Overexpression of B7-H1 on epidermal keratinocytes promotes squamous cell carcinoma2010
- Author(s)
  Cao Y, Zhang L, Ritprajak P, Hashiguchi M, Azuma M
- Organizer
  97th AAI Annual Meeting, American Association of Immunologists, Immunology 2010
- Place of Presentation
  Baltimore, USA
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Enhancement of effector CD8^+T cell function by tumor-associated B7-H3 and modulation of its counter receptor triggering receptor expressed on myeloid cell-like transcript 2(TLT-2) at tumor sites2010
- Author(s)
  H. Kobori, M Hashiguchi, M. Azuma
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-21592385
[Presentation] Triggering receptor expressed on myeloid cells-like transcript 2(TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses in mice and humans2010
- Author(s)
  M. Hashiguchi, H. Kobori, P. Ritprajak, Y. Kamimura, M. Azuma
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-21592385
[Presentation] Triggering receptor expressed on myeloid cells-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances Tcell responses in mice and humans2010
- Author(s)
  Hashiguchi M.
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Analyses of anti-tumor immunity enhanced by a B7-H3 costimulator.2009
- Author(s)
  Kobori H, Hashiguchi M, Piao J, Azuma M
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Tumor-infiltrating CD8+ T cells express TLT-2, a counter receptor for B7-H3 and B7-H3-transduced tumors preferentially augment effector function of CD8^+ T cells2009
- Author(s)
  H.Kobori, M.Hashiguchi, M.Azuma.
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21592385
[Presentation] Tumor-infiltrating CD8^+T cells express TLT-2, a counter receptor for B7-H3 and B7-H3-transduced tumors preferentially augment effector function of CD8^+T cells2009
- Author(s)
  H. Kobori, M. Hashiguchi, M. Azuma
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21592385
[Presentation] Roles of keratinocyte-associated B7-H1 in squamous cell carcinoma formation and growth of tumor cells.2009
- Author(s)
  Cao Y, Hashiguchi M, Azuma M
- Organizer
  第39回日本免疫学会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Mechanisms of effective inhibition by topical application of CD86 siRNA treatment in allergic skin disease.2009
- Author(s)
  Kamimura Y, Ritprajak P, Hashiguchi M, Azuma M
- Organizer
  第39回日本免疫学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Tumor-infiltrating CD8^+ T cells express TLT-2, a counter receptor for B7-H3 and B7-H3-transeduced tumors preferentially augment effector function of CD8+ T cells.2009
- Author(s)
  Kobori H, Hashiguchi M, Piao J, Azuma M
- Organizer
  第39回日本免疫学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Analyses of anti-tumor immunity enhanced by a B7-H3 costimulator2009
- Author(s)
  H. Kobori, M. Hashiguchi, M. Azuma
- Organizer
  日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21592385
[Presentation] Binding property, expression, and function of human TLT2, a counter-receptor for B7-H32009
- Author(s)
  Hashiguchi M, Kobori H, Azuma M
- Organizer
  第39回日本免疫学会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Binding property, expression, and function of human TLT2, a counter-receptor for B7-H32009
- Author(s)
  M. Hashiguchi, H. Kobori, M. Azuma
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21592385
[Presentation] Enhancement of T-cell-mediated anti-tumor immunity via the ectopically expressed GITR ligand on tumors.2009
- Author(s)
  Piao J, Kamimura Y, Cao Y, Hashiguchi M, Azuma M
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Binding property, expression, and function of human TLT2,a counter-receptor for B7-H3.2009
- Author(s)
  Hashiguchi M, Kobori H, Azuma M
- Organizer
  第39回日本免疫学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Roles of keratinocyte-associated B7-H1 in squamous cell carcinoma formation and growth of tumor cells.2009
- Author(s)
  Cao Y, Hashiguchi M, Azuma M
- Organizer
  第39回日本免疫学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Enhancement of T cell-mediated anti-tumor immunity via the ectopically expressed GITRL on tumors.2009
- Author(s)
  Piao J, Kamimura Y, Hashiguchi M, Cao Y, Azuma M
- Organizer
  第39回日本免疫学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Tumor-associated B7-H3 augments cytotoxicity of CD8+ T cells at effector phase.2008
- Author(s)
  Kobori H, Hashiguchi M, Piao J, Azuma M
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] GITR-GITRL pathway modulates migrating capacity of cutaneous DCs in the skin.2008
- Author(s)
  Kamimura Y, Cao Y, Hashiguchi M, Azuma M
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Triggering receptor expressed on myeloid cell-like transcript 2(TLT-2)is a counter-receptor for B7-H3 and enhances T cell responses2008
- Author(s)
  Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Azuma, M.
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19592168
[Presentation] GITRリガンド共刺激はCD4 T細胞のエフェクター機能と制御性機能の両者を活性化する2008
- Author(s)
  Igarashi H, Cao Y, Piao J, Kamimura Y, Hashiguchi M, Azuma M
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Topical application of cream emulsified CD86 siRNA ameliorates allergic skin disease by targeting cutaneous dendritic cells2008
- Author(s)
  Ritprajak P, Hashiguchi M, Azuma M
- Organizer
  38回日本免疫学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Topical application of cream emulsified CD86 siRNA ameliorates allergic skin disease by targeting cutaneous dendritic cells.2008
- Author(s)
  Ritprajak P, Hashiguchi M, Azuma M
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Tumor-associated B7-H3 augments cytotoxicity of CD8^+ T cells at effector phase2008
- Author(s)
  Kobori H, Hashiguchi M, Azuma M, et al.
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2)is acounter-receptor for B7-H3 and enhances T cell responses2008
- Author(s)
  Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Azuma, M.
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2008-03-12
- Data Source
  KAKENHI-PROJECT-19592168
[Presentation] CD28 costimulation affects both susceptibility of effector T cells to regulatory T cells and inhibitory function of Treg.2008
- Author(s)
  Cao Y, Kamimura Y, Hashiguchi M, Azuma M
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20249075
[Presentation] B7-H3 upregulates immune responeses through the ligation with the B7-H3 receptor2007
- Author(s)
  M. Hashiguchi, H. Kobori, P, Ritprajak, J. Piao, M. Azuma
- Organizer
  American Association of Immunologist
- Place of Presentation
  Miami Beach, Florida,USA
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-19592168
[Presentation] B7-H3 upregulates immune responeses through the ligation with the B7-H3 receptor2007
- Author(s)
  Hashiguchi, M., Kobori, H., Ritprajak,P., Piao, J., Azuma, M.
- Organizer
  American Association of Immunologist
- Place of Presentation
  Miami Beach, Florida, USA
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-19592168
[Presentation] NF-κB downregulates IL-5 production via upregulation of T-box proteins
- Author(s)
  Masaaki Hashiguchi, Hidefumi Kojima, Yuji Kashiwakura, Yumiko Kanno, Tetsuji Kobata
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24580196
[Presentation] IL-7 is a principal factor for HIF-1α regulated pro-B development
- Author(s)
  Kanno Y, Kashiwakura T, Hashiguchi M, Kobata T, Kojima H.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] Characterization of activated CD4+ CD25+ regulatory T cells during immune responses
- Author(s)
  Kojima H, Kanno Y, Kashiwakura Y, Hashiguchi M, Kobata T.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] IL-5 is produced by a novel subset of innate lymphoid cell with phenotypes of Lin^- Thy1.2^low-int CD25^+ IL-33Rα^+ in Peyer’s patches
- Author(s)
  Masaaki Hashiguchi, Yuji Kashiwakura, Yumiko Kanno, Hidefumi Kojima, Tetsuji Kobata
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-24580196
[Presentation] Peripheral CD4+ CD25+ regulatory T cell survival is regulated by a combination of CD2 stimuli and the interaction with stromal cells
- Author(s)
  Kashiwakura Y, Kanno Y, Hashiguchi M, Kobata T, Kojima H.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-24591454

1. AZUMA Miyuki (90255654)

# of Collaborated Projects: 10 results

# of Collaborated Products: 57 results
2. HASE Hidenori (70332997)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 小園裕子 (30197107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KOBAYASHI Ayano

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. KOBATA Tetsuji (10205445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
6. KASHIWAKURA Yuji (40382890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
7. 大野建州 (80435635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 神村洋介 (40549929)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 岩井佳子 (90362467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 鍔田武志 (80197756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TASAKU Yumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hashiguchi Masaaki 橋口 昌章

橋口 昌章 ハシグチ マサアキ

HASHIGUCHI Masaaki 橋口 昌章

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パイエル板自然リンパ球およびB細胞による腸内細菌制御Principal Investigator

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パイエル板Ｔｆｈによる抗体産生制御：対立遺伝子排除の破綻とアレルギーの抑制Principal Investigator

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Does IL-21 produced in Peyer's patch regulate the affinity of IgA and food allergy?Principal Investigator

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Peyer's patch immune cells regulates intestinal bacteria: basic research for the manipulation of intestinal bacteria by foodsPrincipal Investigator

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Functional study of IL-5-producing cells in food allergy using GFP marking systemPrincipal Investigator

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Immune regulation of oral disease by co-signal molecule B7-H3 and the novel receptor.Principal Investigator

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Triggering receptor expressed on myeloid cell-like transcript 2(TLT-2)is a counter-receptor for B7-H3 and enhances T cell responsesPrincipal Investigator

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The Regulation of Oral Mucosa Immunity by Immune Co-inhibitory MoleculesPrincipal Investigator

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Hashiguchi Masaaki 橋口昌章

橋口昌章ハシグチマサアキ

HASHIGUCHI Masaaki 橋口昌章