Yamamoto Hideki 山本英樹

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YAMAMOTO Hideki 山本英樹

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Researcher Number	20372691
Other IDs
Affiliation (Current)	2025: 滋慶医療科学大学, 医療科学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 大学院医学系研究科, 招へい教授 2020 – 2021: 大阪大学, 医学系研究科, 招へい教授 2016: 大阪大学, 医学系研究科, 准教授 2011 – 2015: 大阪大学, 医学(系)研究科(研究院), 准教授 2011: 大阪大学, 大学院・医学系研究科, 准教授 … More 2009 – 2011: 大阪大学, 医学系研究科, 准教授 2007 – 2009: 広島大学, 大学院・医歯薬学総合研究科, 准教授 2004 – 2006: Hiroshima University, Graduate School of Biomedical Sciences, Research Associate, 大学院医歯薬学総合研究科, 助手 2004: Hiroshima University, Graduate School of Biomedical Sciences, Research Associate, 大学院・医歯薬学総合研究科, 助手 Less
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 48040:Medical biochemistry-related / Biological Sciences / Pathological medical chemistry Except Principal Investigator General medical chemistry / Biological Sciences
Keywords	Principal Investigator Wntシグナル / Wnt / 受容体 / LRP6 / 細胞内トラフィック / 小胞輸送 / 翻訳後修飾 / クラスリン / Wnt11 / Wnt5a … More / Frizzled / エンドサイトーシス / 分泌タンパク質 / 細胞応答 / 細胞膜 / 小胞体 / LDL / ガレクチン / AP2 / AP1 / 極性分泌 / 糖鎖修飾 / Wntless / 細胞内小胞輸送 / Wntシグナル経路 / Plk1 / 紡錘体形成 / 細胞分裂 / CHMP4B / Frizzled2 / Ror2 / Dvl2 / 細胞質分裂 / LRP6受容体 / Frizzled受容体 / Dkk1 / Rac / 分子病態学 / リン酸化 / カベオリン / β-カテニン / Axin … More Except Principal Investigator Wnt / エンドサイトーシス / GSK-3 / β-カテニン / 転移 / がん / conditioned medium / β-catenin / Tcf / 受容体 / PIASy / PKA / 前立腺癌 / インテグリン / Wnt5a / 極性 / シグナル伝達 / gycosylation / lipidation / Rho-kinase / endocytosis / PC12細胞 / Rhoキナーゼ / ダイナミン / LRP / Frizzled / 糖質修飾 / 脂質修飾 / Rho-キナーゼ / sumoylation / phosphorylation / wnt signal / metastasis / cancer / Rog1 / Rsp5 / Bul / Axin / ストレス応答 / 蛋白質リン酸化酵素PP2A / カゼインキナーゼI / Wntシグナル伝達経路 / Axam / カゼインキナーゼ / 癌 / 蛋白質分解 / APC / Tcf-4 / ユビキチン化 / SUMO化 / リン酸化 / Wntシグナル / クラスリン / リピッドラフト / 接着斑 / Dkkl / 紡錘糸 / MMP / 細胞分裂期 / Dvl / エクトドメイン / β-カテニン非依存性経路 / β-カテニン依存性経路 / グリピカン / ヘパラン硫酸プロテオグリカン / h-prune / SUMO / 胃がん / 翻訳後修飾 / Wnt-5a / JunD / 細胞運動 / ラミニン5γ2 / 細胞周期 / 細胞接着斑 / 胃癌 / がん抑制遺伝子 / がん遺伝子 / 接着 / 分化 Less

Regulation of signal response through a novel DKK1 receptor "CKAP4"Principal Investigator
- Principal Investigator
  
  Yamamoto Hideki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Osaka University
Regulation of membrane traffic of Wnt and its receptorsPrincipal Investigator
- Principal Investigator
  
  Yamamoto Hideki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
Selective activation of Wnt signaling pathway using with purified Wnt proteinsPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Hideki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
細胞分裂期におけるWntシグナル因子Dvlによる紡錘体形成の制御機構Principal Investigator
- Principal Investigator
  
  山本英樹
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Regulation of signaling network and cellular responses by Wnt
- Principal Investigator
  
  KIKUCHI Akira
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
Regulation of Wnt signaling by different endocytic pathwayPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Hideki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
  Hiroshima University
Abnormal Differentiation in Cancer Cells and Intracellular Signaling
- Principal Investigator
  
  KIKUCHI Akira
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
エンドサイトーシスによるWntシグナル伝達経路の制御機構の解析Principal Investigator
- Principal Investigator
  
  山本英樹
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Hiroshima University
Regulation of the Wnt signal by receptor-mediated endocytosis
- Principal Investigator
  
  KIKUCHI Akira
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  HIROSHIMA UNIVERSITY
Identification of intercellular signal transduction molecules and analysis of their functional abnormality in human cancer
- Principal Investigator
  
  KIKUCHI Akira
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  HIROSHIMA UNIVERSITY

[Book] WntシグナルにおけるFrizzled受容体の活性化機構2016
- Author(s)
  山本英樹, 菊池章
- Total Pages
  9
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-26460365
[Book] サイトカイン・増殖因子キーワード事典2015
- Author(s)
  菊池章、山本英樹
- Total Pages
  3
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26460365
[Book] The Lipid2014
- Author(s)
  山本英樹、菊池章
- Total Pages
  7
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-26460365
[Book] 極性化上皮細胞におけるWnt分泌制御2013
- Author(s)
  山本　英樹
- Total Pages
  8
- Publisher
  細胞工学（秀潤社）
- Data Source
  KAKENHI-PROJECT-23590333
[Book] 極性化上皮細胞におけるWntの分泌制御2013
- Author(s)
  山本　英樹、菊池　章
- Total Pages
  8
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-23590333
[Book] 実験医学2005
- Author(s)
  山本英樹他2名
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17790192
[Journal Article] CKAP4 is a potential exosomal biomarker and therapeutic target for lung cancer2023
- Author(s)
  Nagoya Akihiro、Sada Ryota、Kimura Hirokazu、Yamamoto Hideki、Morishita Koichi、Miyoshi Eiji、Morii Eiichi、Shintani Yasushi、Kikuchi Akira
- Journal Title
  
  Translational Lung Cancer Research
  
  Volume: 12 Issue: 3 Pages: 408-426
- DOI
  10.21037/tlcr-22-571
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15511, KAKENHI-PROJECT-21H04797, KAKENHI-PROJECT-21K19407, KAKENHI-PROJECT-20K16330, KAKENHI-PROJECT-20K17746, KAKENHI-PROJECT-20K07311, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23K24228
[Journal Article] The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers2021
- Author(s)
  Kimura Hirokazu、Sada Ryota、Takada Naoki、Harada Akikazu、Doki Yuichiro、Eguchi Hidetoshi、Yamamoto Hideki、Kikuchi Akira
- Journal Title
  
  Oncogene
  
  Volume: 40 Issue: 26 Pages: 4486-4502
- DOI
  10.1038/s41388-021-01860-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07311, KAKENHI-PROJECT-21K19407, KAKENHI-PROJECT-20K16330, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-21H04797
[Journal Article] Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin.2016
- Author(s)
  Mihara, E., Hirai, H., Yamamoto, H., Tamura-Kawakami, K., Matano, M., Kikuchi, A., Sato, T., and Takagi, J.
- Journal Title
  
  Elife
  
  Volume: 5 Pages: 1-19
- DOI
  10.7554/elife.11621
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460365, KAKENHI-PROJECT-15K15297, KAKENHI-ORGANIZER-23112001, KAKENHI-PLANNED-23112004, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-25250018, KAKENHI-PROJECT-26860528, KAKENHI-PROJECT-26293177, KAKENHI-WRAPUP-16H01696, KAKENHI-PROJECT-16K09325
[Journal Article] Wnt5b-associated Exosomes promote cell proliferation and migration in a cancer cell context2016
- Author(s)
  Harada, T., Yamamoto, H., Kishida, S., Kishida, M., Awada, C., Takao, T., and Kikuchi, A.
- Journal Title
  
  Cancer Sci.
  
  Volume: 108 Issue: 1 Pages: 42-52
- DOI
  10.1111/cas.13109
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460365, KAKENHI-PROJECT-16H06374
[Journal Article] Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively2015
- Author(s)
  Shojima, K., Sato, A., Hanaki, H., Tsujimoto, I., Nakamura, M., Hattori, K., Sato, Y., Dohi, K., Hirata, M., Yamamoto, H., and Kikuchi, A.
- Journal Title
  
  Sci. Rep.
  
  Volume: 5 Issue: 1 Pages: 8042-8042
- DOI
  10.1038/srep08042
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-23112001, KAKENHI-PLANNED-23112004, KAKENHI-PROJECT-24590378, KAKENHI-PROJECT-25250018, KAKENHI-PROJECT-26460365
[Journal Article] A. Basolateral secretion of Wnt5a in polarized epithelial cells is required for apical lumen formation2015
- Author(s)
  Yamamoto, H., Awada, C., Matsumoto, S., Kaneiwa, T., Sugimoto, T., Takao, T., and Kikuchi
- Journal Title
  
  J. Cell Sci.
  
  Volume: 128 Pages: 1051-1063
- DOI
  10.1242/jcs.163683
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860211, KAKENHI-PROJECT-15K08272, KAKENHI-PROJECT-26460365, KAKENHI-ORGANIZER-23112001, KAKENHI-PLANNED-23112004, KAKENHI-PROJECT-25250018
[Journal Article] The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by distinct mechanisms.2013
- Author(s)
  Yamamoto, H., Awada, C., Hanaki, H., Sakane, H., Tsujimoto, I., Takahashi, Y., Takao, T., and Kikuchi, A.
- Journal Title
  
  J. Cell Sci.
  
  Volume: 126 Pages: 2931-2943
- DOI
  10.1242/jcs.126052
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-23112001, KAKENHI-PLANNED-23112004, KAKENHI-PROJECT-23590333, KAKENHI-PROJECT-24790280, KAKENHI-PROJECT-25250018
[Journal Article] Apicobasal secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by distinct mechanisms2013
- Author(s)
  Yamamoto, H. et. al
- Journal Title
  
  J. Cell Sci.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590333
[Journal Article] An Wnt5a-antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis2012
- Author(s)
  Hanaki, H., Yamamoto, H., Sakane, H., Matsumoto, S., Ohdan, H., Sato, A., and Kikuchi, A
- Journal Title
  
  Mol. Cancer Ther
  
  Volume: 11 Pages: 298-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017
[Journal Article] Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling2012
- Author(s)
  Sakane, H., et.al.
- Journal Title
  
  J.Cell Sci.
  
  Volume: 125 Issue: 2 Pages: 449-460
- DOI
  10.1242/jcs.091876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017, KAKENHI-PUBLICLY-22019025, KAKENHI-PROJECT-22770127, KAKENHI-PROJECT-22790316, KAKENHI-ORGANIZER-23112001, KAKENHI-PROJECT-23590333, KAKENHI-PROJECT-23650594, KAKENHI-PROJECT-23790333, KAKENHI-PROJECT-24590378, KAKENHI-PLANNED-23112004
[Journal Article] Wnt5a : its signaling, functions, and implication in diseases2012
- Author(s)
  Kikuchi, A., Yamamoto, H., Sato, A., and Maysimoto, S
- Journal Title
  
  Acta physiol
  
  Volume: 204 Pages: 17-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017
[Journal Article] Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling2012
- Author(s)
  Sakane, H., Yamamoto, H., Matsumoto, S., Sato, A., and Kikuchi, A
- Journal Title
  
  J. Cell Sci
  
  Volume: 125 Pages: 449-460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017
[Journal Article] An Wnt5a-antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis2012
- Author(s)
  Hanaki, H., et.al.
- Journal Title
  
  Mol.Cancer Ther.
  
  Volume: 11 Issue: 2 Pages: 298-307
- DOI
  10.1158/1535-7163.mct-11-0682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017, KAKENHI-PUBLICLY-22019025, KAKENHI-PROJECT-22770127, KAKENHI-PROJECT-22790316, KAKENHI-ORGANIZER-23112001, KAKENHI-PROJECT-23590333, KAKENHI-PROJECT-23790333, KAKENHI-PROJECT-24590378, KAKENHI-PLANNED-23112004
[Journal Article] Wnt5a : its signaling, functions, and implication in diseases2012
- Author(s)
  Kikuchi, A., et.al.
- Journal Title
  
  Acta Physiol.
  
  Volume: 204 Issue: 1 Pages: 17-33
- DOI
  10.1111/j.1748-1716.2011.02294.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017, KAKENHI-PROJECT-22770127, KAKENHI-ORGANIZER-23112001, KAKENHI-PROJECT-23590333, KAKENHI-PROJECT-23650594, KAKENHI-PROJECT-24590378, KAKENHI-PLANNED-23112004
[Journal Article] New insights into the mechanism of Wnt signaling pathway activation2011
- Author(s)
  Kikuchi, A., Yamamoto, H., Sato, A., Mastumoto, S
- Journal Title
  
  Int. Rev. Cell. Mol. Biol
  
  Volume: 291 Pages: 21-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017
[Journal Article] New insights into the mechanism of Wnt signaling pathway activation2011
- Author(s)
  Kikuchi, A
- Journal Title
  
  Int Rev Cell Mol Biol.
  
  Volume: 291 Pages: 21-71
- DOI
  10.1016/b978-0-12-386035-4.00002-1
- ISBN
  9780123860354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017, KAKENHI-PUBLICLY-22019025, KAKENHI-PROJECT-22770127, KAKENHI-ORGANIZER-23112001, KAKENHI-PLANNED-23112004, KAKENHI-PROJECT-23590333, KAKENHI-PROJECT-23650594, KAKENHI-PROJECT-23790333
[Journal Article] Waif1/5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization2011
- Author(s)
  Kagermeier-Schenk, B., et.al.
- Journal Title
  
  Dev.Cell.
  
  Volume: 21 Issue: 6 Pages: 1129-1143
- DOI
  10.1016/j.devcel.2011.10.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017, KAKENHI-PUBLICLY-22019025, KAKENHI-ORGANIZER-23112001, KAKENHI-PLANNED-23112004, KAKENHI-PROJECT-23590333
[Journal Article] The transmembrane protein Waif1/ 5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization2011
- Author(s)
  Kagermeier-Schenk, B., Wehner, D., Ozhan-Kizil, G., Yamamoto, H., Jian Li, Kirchner, K., Hoffmann, C., Stern, P., Kikuchi, A., Schambony, A., and Weidinger, G
- Journal Title
  
  Dev. Cell
  
  Volume: 21 Pages: 1129-1143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017
[Journal Article] The transmembrane protein Waif1/5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization2011
- Author(s)
  Kagermeier-Schenk, B., Wehner, D., Ö z h a n -Kizil, G. Yamamoto, H., Li, J., Kirchner, K., Hoffmann, C., Stern, P., Kikuchi, A., Schambony, A., Weidinger, G.
- Journal Title
  
  Dev. Cell
  
  Volume: 21 Issue: 4 Pages: 1129-1143
- DOI
  10.1016/j.devcel.2013.07.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590333
[Journal Article] Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase.2010
- Author(s)
  Yamamoto,H., Oue,N., Sato,A., Hasegawa,Y., Matsubara,A., Yamamoto,H., Yasui,W., Kikuch,A
- Journal Title
  
  Oncogene 29
  
  Pages: 2036-2046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase.2010
- Author(s)
  Yamamoto, H., et.al.
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 2036-2046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase.2010
- Author(s)
  Yamamoto, H., Oue, N., Sato, A., Hasegawa, Y., Yamamoto, H., Matsubara, A., Yasui, W., Kikuchi, A.
- Journal Title
  
  Oncogene 29
  
  Pages: 2036-2046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790320
[Journal Article] Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase2010
- Author(s)
  Yamamoto, H., Oue, N., Sato, A., Hasegawa, Y., Matsubara, A., Yamamoto, H., Yasui, W., and Kikuch, A
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 2036-2046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017
[Journal Article] Wnt5a regulates distinct signaling pathways by binding to Frizzled22010
- Author(s)
  Sato, A., Yamamoto, H., Sakane, H., Koyama, H., and Kikuchi, A
- Journal Title
  
  EMBO J
  
  Volume: 29 Pages: 41-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017
[Journal Article] Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase.2010
- Author(s)
  Yamamoto, H., Kikuchi, A..
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 2036-2046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017
[Journal Article] Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase2010
- Author(s)
  Yamamoto, H., et al.
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 2036-2046
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22019025
[Journal Article] LRP6 is internalized by Dkkl to suppress its phosphorylation in the lipid raft and is recycled for reuse.2010
- Author(s)
  Sakane, H., Yamamoto, H., Kikuchi, A.
- Journal Title
  
  J.Cell Sci. 123
  
  Pages: 360-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790320
[Journal Article] Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metallonroteinase2010
- Author(s)
  Yamamoto H, et al.
- Journal Title
  
  Oncogene (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790320
[Journal Article] Wnt5a regulates distinct signaling pathways by binding to Frizzled2.2010
- Author(s)
  Sato, A.,Yamamoto, H.,Sakane, H., Koyama, H., Kikuchi, A.
- Journal Title
  
  EMBO J. 29
  
  Pages: 41-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790320
[Journal Article] LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse2010
- Author(s)
  Sakane, H., Yamamoto, H., and Kikuchi, A
- Journal Title
  
  J. Cell Sci
  
  Volume: 123 Pages: 360-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017
[Journal Article] Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase2010
- Author(s)
  Yamamoto, H., et al.
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 2036-2046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790320
[Journal Article] LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse.2010
- Author(s)
  Sakane,H., Yamamoto,H., Kikuchi,A
- Journal Title
  
  J.Cell Sci. 123
  
  Pages: 360-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Wnt5a regulates distinct signaling pathways by binding to Frizzled2.2010
- Author(s)
  Sato,A., Yamamoto,H., Sakane,H., Koyama,H., Kikuchi,A
- Journal Title
  
  EMBO J. 29
  
  Pages: 41-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Laminin γ2 mediates Wnt5a-induced invasion of Gastric Cancer Cells2009
- Author(s)
  Yamamoto, H., et.al.
- Journal Title
  
  Gastroenterology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Laminin γ2 Mediates Wnt5a-induced Invasion of Gastric Cancer Cells.2009
- Author(s)
  Yamamoto, H., et.al.
- Journal Title
  
  Gastroenterology
  
  Volume: 137 Pages: 242-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Laminin・2 mediates Wnt5a-induced invasion of gastric cancer cells2009
- Author(s)
  Yamamoto, H., Kitadai, . Y., Yamamoto, H., Oue, N., Ohdan, H., Yasui, W., and Kikuchi, A
- Journal Title
  
  Gastroenterology
  
  Volume: 137 Pages: 242-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017
[Journal Article] Laminin γ2 Mediates Wnt5a-induced Invasion of Gastric Cancer Cells.2009
- Author(s)
  Yamamoto, H., et.al.
- Journal Title
  
  Gastroenterology
  
  Volume: 137 Pages: 242-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017
[Journal Article] Laminin・2 mediates Wnt5a-induced invasion of gastric cancer cells.2009
- Author(s)
  Yamamoto,H., Kitadai,.Y., Yamamoto,H., Oue,N., Ohdan,H., Yasui,W., Kikuchi,A
- Journal Title
  
  Gastroenterology 137
  
  Pages: 242-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Selective activation mechanisms of Wnt signaling pathways.2009
- Author(s)
  Kikuchi,A., Yamamoto,H., Sato,A
- Journal Title
  
  Trends Cell Biol. 19
  
  Pages: 119-129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Selective activation of mechanisms of Wnt signaling pathways.2009
- Author(s)
  Kikuchi, A.,Yamamoto, H.,and Sato, A.
- Journal Title
  
  Trends Cell Biol. 19
  
  Pages: 119-129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790320
[Journal Article] Laminin・2 mediates Wnt5a-induced invasion of Gastric Cancer Cells.2009
- Author(s)
  Yamamoto, H.,Kitadai, Y.,Yamamoto, H., Oue, N., Ohdan, H., Yasui, W., Kikuchi, A.
- Journal Title
  
  Gastroenterology 137
  
  Pages: 242-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790320
[Journal Article] Selective activation mechanisms of Wnt signaling pathways2009
- Author(s)
  Kikuchi, A., Yamamoto, H., and Sato, A
- Journal Title
  
  Trends Cell Biol
  
  Volume: 19 Pages: 119-129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249017
[Journal Article] Laminin γ2 mediates Wnt5a-induced invasion of gastric cancer cells2009
- Author(s)
  Yamamoto H, et al.
- Journal Title
  
  Gastroenterology 137
  
  Pages: 242-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790320
[Journal Article] Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of ・-catenin signaling.2008
- Author(s)
  Yamamoto,H., Sakane,H., Yamamoto,H., Michiue,T., Kikuch,A
- Journal Title
  
  Dev. Cell 15
  
  Pages: 37-48
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Tumor formation due to abnormalities in the ・-catenin-independent pathway of Wnt signaling.2008
- Author(s)
  Kikuchi,A. Yamamoto,H
- Journal Title
  
  Cancer Sci. 99
  
  Pages: 202-208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Wnt3a and Dkkl regulate internalization of LRP6 differently to tune β-catenin pathway・2008
- Author(s)
  Yamamoto, H., et. al.
- Journal Title
  
  Dev. Cell (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of β-catenin signaling2008
- Author(s)
  Yamamoto, H., et.al.
- Journal Title
  
  Dev. Cell 15
  
  Pages: 37-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Tumor formation due to abnormalities in the β-catenin-independent pathway of Wnt siqnaling.2008
- Author(s)
  Kikuchi, A. Yamamoto, H.
- Journal Title
  
  Cancer Sci. 99
  
  Pages: 202-208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a.2007
- Author(s)
  Komekado,H., Yamamoto,H., Chiba,T., Kikuchi,A
- Journal Title
  
  Genes Cells 12
  
  Pages: 521-534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Wnt5a modulates glycogen synthase kinase 3 to induce phospshorylation of receptor tyrosine kinase Ror2.2007
- Author(s)
  Yamamoto, H., et. al.
- Journal Title
  
  Genes Cells 12
  
  Pages: 1215-1223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signaling.2007
- Author(s)
  Kurayoshi,M., Yamamoto,H., Takada,S., Izumi,S., Kikuchi,A
- Journal Title
  
  Biochem.J. 402
  
  Pages: 515-523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Regulation of Wnt signaling by receptor-mediated endocytosis.2007
- Author(s)
  Kikuchi,A. Yamamoto,H
- Journal Title
  
  J.Biochem. 141
  
  Pages: 443-451
- NAID
  10020099687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Multiplicity of the interactions of Wnt proteins and their receptors.2007
- Author(s)
  Kikuchi,A., Kishida,S., Yamamoto,H
- Journal Title
  
  Cell.Signal. 19
  
  Pages: 659-671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Caveolin is necessary for Wnt-3a-induced internalization of LRP6 and accumulation of ・-catenin.2006
- Author(s)
  Yamamoto,H., Komekado,H., Kikuchi,A
- Journal Title
  
  Dev.Cell 11
  
  Pages: 213-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Caveolin is necessary.for Wnt-3a-induced internalization of LRP6 and accumulation of β-catenin.2006
- Author(s)
  Yamamoto, H. et al.
- Journal Title
  
  Dev. Cell 11
  
  Pages: 213-223
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Regulation of Wnt signaling by protein-protein interaction and post-translational modifications.2006
- Author(s)
  Kikuchi,A., Kishida,S., Yamamoto,H
- Journal Title
  
  Experi.&Mol.Med. 38
  
  Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of β-catenin2006
- Author(s)
  Hideki Yamamoto, et al.
- Journal Title
  
  Dev. Cell 11・2
  
  Pages: 213-223
- Data Source
  KAKENHI-PROJECT-17790192
[Journal Article] Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion.2006
- Author(s)
  Kurayoshi,M., Oue,N., Yamamoto,H., Kishida,M., Inoue,A., Asahara,T., Yasui,W., Kikuchi,A
- Journal Title
  
  Cancer Res. 66
  
  Pages: 10439-10448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4.2005
- Author(s)
  Ihara,M., Yamamoto,H., Kikuchi,A
- Journal Title
  
  Mol.Cell.Biol. 25
  
  Pages: 3506-3518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014066
[Journal Article] Sumoylation is involved in β-catenin-dependent activation of Tcf-4.2003
- Author(s)
  Yamamoto, H.
- Journal Title
  
  EMBO J. 22
  
  Pages: 2047-2059
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219214
[Journal Article] Sumoylation is involved in β-catenin-dependent activation of Tcf-4.2003
- Author(s)
  Yamamoto H.
- Journal Title
  
  EMBO J. 22
  
  Pages: 2047-2059
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390094
[Journal Article] Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A.2001
- Author(s)
  Yamamoto, H.
- Journal Title
  
  J. Biol. Chem. 276
  
  Pages: 26875-26882
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219214
[Presentation] DKK1受容体CKPA4の細胞内輸送制御の解析2023
- Author(s)
  山本英樹、佐田遼太、菊池章
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07311
[Presentation] 新規DKK1受容体CKPA4の細胞内輸送制御2022
- Author(s)
  山本英樹, 佐田遼太, 菊池章
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07311
[Presentation] DKK1受容体CKAP4による細胞応答制御2021
- Author(s)
  山本英樹
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07311
[Presentation] Dynamic palmitoylation determines membrane microdomain localization of two DKK1 receptors CKAP4 and LRP6, and regulates DKK1 signaling2020
- Author(s)
  山本英樹, 佐田遼太, 木村公一, 菊池章
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07311
[Presentation] 肝細胞におけるLDLによるLRP6の異なるエンドサイトーシス経路の制御機構2016
- Author(s)
  山本英樹、梅田大介、松本真司、菊池章
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-26460365
[Presentation] エキソソーム上のWnt5bは細胞環境に応じて、がん細胞の増殖と運動を制御する2016
- Author(s)
  原田武志、山本英樹、菊池章
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-26460365
[Presentation] Wnt5bの細胞外分泌機構とその生理機能の解析2015
- Author(s)
  原田武志, 山本英樹, 菊池章
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26460365
[Presentation] Wnt5aの極性分泌による上皮細胞の内腔形成制御機構2015
- Author(s)
  山本英樹, 粟田ちひろ, 高尾敏文, 菊池章
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26460365
[Presentation] 翻訳後修飾によるWnt5aの細胞外分泌の制御機構2014
- Author(s)
  杉本崇行, 山本英樹, 金岩　知之, 粟田ちひろ, 高尾敏文, 坂根洋, 菊池章
- Organizer
  日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-26460365
[Presentation] 極性化された上皮細胞におけるWntとその受容体の輸送制御機構2014
- Author(s)
  山本英樹, 金岩　知之, 粟田ちひろ, 高尾敏文, 菊池章
- Organizer
  日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-26460365
[Presentation] 極性化された上皮細胞におけるWntの分泌制御機構2013
- Author(s)
  山本英樹, 花木英明, 辻本育子, 金岩知之, 粟田ちひろ, 高尾敏文, 菊池章
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590333
[Presentation] 翻訳後修飾によるWnt11の機能発現の制御2012
- Author(s)
  山本英樹, 花木英明, 辻本育子, 粟田ちひろ, 高尾敏文, 菊池章
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590333
[Presentation] 翻訳後修飾によるWnt11蛋白質の機能発現の制御2012
- Author(s)
  山本　英樹
- Organizer
  生化学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590333
[Presentation] 翻訳後修飾によるWnt蛋白質の機能発現の制御2011
- Author(s)
  山本英樹
- Organizer
  生化学会
- Place of Presentation
  京都国際会館(京都府)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PUBLICLY-22019025
[Presentation] 翻訳後修飾によるWnt蛋白質の機能発現の制御2011
- Author(s)
  山本　英樹
- Organizer
  生化学会
- Place of Presentation
  京都国際会館（京都府）
- Data Source
  KAKENHI-PROJECT-23590333
[Presentation] 翻訳後修飾によるWnt蛋白質の機能発現の制御2011
- Author(s)
  山本英樹, 粟田ちひろ, 高尾敏文, 岸田昭世, 岸田想子, 菊池章
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590333
[Presentation] Wnt5a-dependent activation of Rac through the internalization of Frizzled receptor2010
- Author(s)
  山本英樹
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21790320
[Presentation] Wnt5a-dependent activation of Rac throug the internalization of Frizzled receptor2010
- Author(s)
  山本英樹、佐藤朗、坂根洋、菊池章
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790320
[Presentation] Wnt5a-dependent activation of Rac through the internalization of Frizzled receptor2010
- Author(s)
  山本英樹
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PUBLICLY-22019025
[Presentation] 異なる受容体エンドサイトーシス経路を介するWntシグナル伝達の制御機構2009
- Author(s)
  山本英樹、坂根洋、菊池章
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790320
[Presentation] クラスリンを介するエンドサイトーシスによるWnt5a依存性のRacの活性化2009
- Author(s)
  山本英樹
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-21790320
[Presentation] 異なる受容体エンドサイトーシス経路を介するWntシグナル伝達の制御機構2009
- Author(s)
  山本英樹
- Organizer
  日本化学会
- Place of Presentation
  神戸ポートビプホテル(神戸市)
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-21790320
[Presentation] 脂質ラフトにおけるWntシグナルの活性制御2008
- Author(s)
  山本英樹
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17014066
[Presentation] Wnt5aはlaminin-5γ2の発現を介して胃癌細胞の転移能を促進する2008
- Author(s)
  山本英喜
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17014066
[Presentation] Expression of Wnt5a is correlated with aggressiveness of gastric and prostate cancer by stimulating cell migration and invasion.2007
- Author(s)
  Kikuchi, A., Yamamoto,H
- Organizer
  Traditional Wnt meeting.
- Place of Presentation
  La Jolla. California, USA
- Year and Date
  2007-06-22
- Data Source
  KAKENHI-PROJECT-17014066
[Presentation] Expression of Wnt5a is correlated with aggressiveness of gastric and prostate cancer by stimulating cell miqration andinvasion.2007
- Author(s)
  Kikuchi. A. Yamamoto. H.
- Organizer
  Traditional Wnt meeting.
- Place of Presentation
  La Jolla.California, USA
- Year and Date
  2007-06-22
- Data Source
  KAKENHI-PROJECT-17014066
[Presentation] 極性化された上皮細胞におけるWntの分泌制御機構
- Author(s)
  山本英樹, 花木　英明, 辻本　育子, 粟田ちひろ, 高尾敏文, 菊池章
- Organizer
  生化学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23590333

1. KIKUCHI Akira (10204827)

# of Collaborated Projects: 4 results

# of Collaborated Products: 30 results
2. HINO Shin-ichirou (00372699)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SATO Akira (70464302)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
4. KISHIDA Michiko (40274089)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. TAKAO Toshifumi (10197048)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
6. KISHIDA Shosei (50274064)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 小山眞也 (00186834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 安東知子 (20294548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 佐田遼太 (60869783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. 松本真司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamamoto Hideki 山本 英樹

YAMAMOTO Hideki 山本 英樹

Research Projects

Research Products

Co-Researchers

Regulation of signal response through a novel DKK1 receptor "CKAP4"Principal Investigator

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Regulation of membrane traffic of Wnt and its receptorsPrincipal Investigator

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Selective activation of Wnt signaling pathway using with purified Wnt proteinsPrincipal Investigator

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細胞分裂期におけるWntシグナル因子Dvlによる紡錘体形成の制御機構Principal Investigator

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Regulation of signaling network and cellular responses by Wnt

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Regulation of Wnt signaling by different endocytic pathwayPrincipal Investigator

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Abnormal Differentiation in Cancer Cells and Intracellular Signaling

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エンドサイトーシスによるWntシグナル伝達経路の制御機構の解析Principal Investigator

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Research Institution

Regulation of the Wnt signal by receptor-mediated endocytosis

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Identification of intercellular signal transduction molecules and analysis of their functional abnormality in human cancer

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[Book] WntシグナルにおけるFrizzled受容体の活性化機構2016

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[Book] サイトカイン・増殖因子キーワード事典2015

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[Book] The Lipid2014

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Yamamoto Hideki 山本英樹

YAMAMOTO Hideki 山本英樹