TAKADA Minoru 高田實

Researcher Number	20373516
Affiliation (based on the past Project Information) *help	2014: 阪和第二泉北病院, 副院長 2008: 独立行政法人国立病院機構近畿中央胸部疾患センター, 臨床研究センター, 肺がん研究部長 2007: 国立病院機構近畿中央胸部疾患センター, 臨床研究センター・肺がん研究部, 部長 2005 – 2006: 独立行政法人国立病院機構(近畿中央胸部疾患センター臨床研究センター), 肺がん研究部, 部長
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine Except Principal Investigator Clinical oncology / Respiratory organ internal medicine
Keywords	Principal Investigator dimerization / auto-phosphorylation / gene amplification / somatic mutation / tyrosine kinase inhibitor / Epidermal Growth Factor / Non Small Cell Lung Cancer / KRAS / コピー数の増加 / インフレーム変異 … More / ミスセンス変異 / Gefitinib / EGFR-TKIs / EGFR / 非小細胞肺癌 / チロシンキナーゼ阻害剤(TKIs) / 二量体形成 / 自己リン酸化 / 遺伝子増幅 / 遺伝子変異 / チロシンキナーゼ阻害剤 / 上皮成長因子受容体(EGFR) / 非肺小細胞癌(NSCLC) … More Except Principal Investigator サイトケラチン / 化学療法 / FDG-PET / 薬物動態 / 薬力学 / 分子標的治療 / 癌性胸膜炎 / 非小細胞肺癌 / 応用動物 / グラニュライシン / 免疫学 / 癌 / 免疫療法 / 肺癌 Less

Nobel pharmacodynamics evaluation of molecular targeting agents: PHarmacokinetic/PHarmacodynamic Assessment on Malignant Effusions (PHAME)
- Principal Investigator
  
  KUBO Akihito
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Aichi Medical University
Analysis of cytotoxic effect of human Granulysin by using novel PK/PD model
- Principal Investigator
  
  KUBO Akihito
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Clinical Research Center, National Hospital Organization, Kinki-Chuo Chest Medical Center
Investigation of the relationship between EGFR gene status and clinical effect and the elucidation of the resistance mechanismPrincipal Investigator
- Principal Investigator
  
  TAKADA Minoru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  NHO Kinki-Chuo Chest Medical Center Clinical Research Center

All 2015 2014 2013 2011 2007 2005 Other

All Journal Article Presentation

[Journal Article] The role of smoking status on the progression-free survival of non-small-cell lung cancer patients harboring activating epidermal growth factor (EGFR) mutations receiving first-line EGFR tyrosine kinase inhibitor: a meta-analysis of prospective randomized trials.2015
- Author(s)
  Hasegawa Y, Ando M, Maemondo M, Yamamoto S, Isa S, Saka H, Kubo A, Kawaguchi T, Takada M, Rosell R, Kurata T, Ou SH.
- Journal Title
  
  The Oncologist
  
  Volume: 20 Issue: 3 Pages: 1-9
- DOI
  10.1634/theoncologist.2014-0285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501314, KAKENHI-PROJECT-15K09237, KAKENHI-PROJECT-25460896
[Journal Article] Role of consolidation chemotherapy after concurrent chemo-radiotherapy in locally advanced non-small-cell lung cancer.2014
- Author(s)
  Tsujino K, Kurata T, Kawaguchi T, Kubo A, Takada M, Ando M.
- Journal Title
  
  J Thorac Oncol
  
  Volume: 9 Issue: 1 Pages: e7-e8
- DOI
  10.1097/jto.0000000000000035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501314, KAKENHI-PROJECT-25460896
[Journal Article] Long-term complete response in a patient with disseminated pulmonary pleomorphic carcinoma induced by cisplatin and gemcitabine.2014
- Author(s)
  Tamiya A, Asami K, Shimizu S, Matusmura A, Isa S-I, Okishio K, Kitaichi M, Atagi S, Takada M, Kawaguchi T, Kubo A
- Journal Title
  
  Internal Medicine (in press)
  
  Volume: na
- NAID
  130004713245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501314
[Journal Article] Randomized phase III trial of erlotinib versus docetaxel as second- or third-line therapy in patients with advanced non-small cell lung cancer: Docetaxel and Erlotinib Lung cancer TriAl (DELTA).2014
- Author(s)
  Kawaguchi T, Ando M, Asami K, Okano Y, Fukuda M, Nakagawa H, Ibata H, Kozuki T, Endo T, Tamura A, Kamimura M, Sakamoto K, Yoshimi M, Soejima Y, Tomizawa Y, Isa S, Takada M, Saka H, Kubo A.
- Journal Title
  
  J Clin Oncol
  
  Volume: 32 Issue: 18 Pages: 1902-8
- DOI
  10.1200/jco.2013.52.4694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501314, KAKENHI-PROJECT-25460896
[Journal Article] Human papilloma virus in non-small cell lung cancer in never smokers: A systematic review of the literature.2014
- Author(s)
  Hasegawa Y, Ando M, Kubo A, Isa SI, Yamamoto S, Tsujino K, Kurata T, Ou SH, Takada M, Kawaguchi T
- Journal Title
  
  Lung Cancer
  
  Volume: 8 Issue: 1 Pages: 8-13
- DOI
  10.1016/j.lungcan.2013.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501314, KAKENHI-PROJECT-25460896
[Journal Article] Randomized phase III trial of erlotinib versus docetaxel as second- or third-line therapy in patients with advanced non-small cell lung cancer: Docetaxel and Erlotinib Lung cancer TriAl (DELTA).2014
- Author(s)
  Kawaguchi T, Ando M, Asami K, Okano Y, Fukuda M, Nakagawa H, Ibata H, Kozuki T, Endo T, Tamura A, Kamimura M, Sakamoto K, Yoshimi M, Soejima Y, Tomizawa Y, Isa S, Takada M, Saka H, Kubo A
- Journal Title
  
  J Clin Oncol (in press)
  
  Volume: na
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501314
[Journal Article] Long-term Complete Response in a Patient with Disseminated Pulmonary Pleomorphic Carcinoma Induced by Cisplatin and Gemcitabine2014
- Author(s)
  Tamiya A, Asami K, Shimizu S, Matusmura A, Isa S-I, Okishio K, Kitaichi M, Atagi S, Takada M, Kawaguchi T, Kubo A.
- Journal Title
  
  Intern. Med.
  
  Volume: 53 Issue: 22 Pages: 2625-2628
- DOI
  10.2169/internalmedicine.53.2637
- NAID
  130004713245
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23501314
[Journal Article] Is Consolidation Chemotherapy after Concurrent Chemo-Radiotherapy Beneficial for Patients with Locally Advanced Non-Small-Cell Lung Cancer?: A Pooled Analysis of the Literature.2013
- Author(s)
  Tsujino K, Kurata T, Yamamoto S, Kawaguchi T, Kubo A, Isa S, Hasegawa Y, Ou SH, Takada M, Ando M
- Journal Title
  
  J Thorac Oncol
  
  Volume: 8 Issue: 9 Pages: 1181-9
- DOI
  10.1097/jto.0b013e3182988348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501314, KAKENHI-PROJECT-25460896
[Journal Article] Differential constitutive activation of the Epidermal Growth Factor Receptor (EGFR) in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.2007
- Author(s)
  Okabe T, Okamoto I, Tamura K, Terashima M, Yoshida T, Satoh T, Takada M, Fukuoka M, Nakagawa K
- Journal Title
  
  Cancer Res 67(5)
  
  Pages: 2046-2053
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590812
[Journal Article] EGFR変異とゲフィチニブの臨床効果が相関しなかった1例2005
- Author(s)
  高田實
- Journal Title
  
  分子呼吸器病 Vol.9 No.4
  
  Pages: 58-62
- Data Source
  KAKENHI-PROJECT-17590812
[Journal Article] EGFR変異とゲフィチニブの臨床効果が相関しなかった1例2005
- Author(s)
  高田實
- Journal Title
  
  分子呼吸器病 Vol. 9 No. 4
  
  Pages: 58-62
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590812
[Presentation] Randomized phase III trial of erlotinib (E) versus (v) docetaxel (D) as second or third line therapy in patients with advanced non-small cell lung cancer (NSCLC) who have wild type or mutant epidermal growth factor receptor (EGFR): Docetaxel and Erlotinib Lung cancer TriAl (DELTA).2013
- Author(s)
  Okano Y, Ando M, Asami K, Fukuda M, Nakagawa H, Ibata H, Kozuki T, Endo T, Tamura A, Kamimura M, Sakamoto K, Yoshimi M, Soejima Y, Tomizawa Y, Isa S, Takada M, Saka H, Kubo A, Kawaguchi T.
- Organizer
  Annual Meeting of the American Society of Clinical Oncology
- Place of Presentation
  Chicago, IL, USA
- Data Source
  KAKENHI-PROJECT-23501314
[Presentation] 非小細胞肺癌(NSCLC)の癌性胸膜炎(MPE)におけるゲフィチニブの薬力学・薬物動態・臨床第II相試験2011
- Author(s)
  久保昭仁、洪　泰浩、堀　隆、伊佐俊一、福岡順也、川口知哉、安藤昌彦、岡本　勇、北市正則、安宅信二、河原正明、楠　洋子、山口悦郎、中川和彦、高田　實
- Organizer
  第51回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23501314
[Presentation] Updated overall survival (OS) results of randomized phase III trial of erlotinib (E) versus (v) docetaxel (D) as second or third line therapy in patients with advanced non-small cell lung cancer (NSCLC): Docetaxel and Erlotinib Lung cancer TriAl (DELTA).
- Author(s)
  Ibata H, Ando M, Asami K, Okano Y, Fukuda M, Nakagawa H, Kozuki T, Endo T, Tamura A, Kamimura M, Sakamoto K, Yoshimi M, Soejima Y, Tomizawa Y, Isa S, Takada M, Saka H, Kubo A, Kawaguchi T.
- Organizer
  Annual Meeting of the American Society of Clinical Oncology
- Place of Presentation
  Chicago, IL, USA.
- Year and Date
  2014-05-30 – 2014-06-03
- Data Source
  KAKENHI-PROJECT-23501314
[Presentation] The role of smoking status on the progression-free survival of non-small-cell lung cancer patients harboring activating epidermal growth factor (EGFR) mutations receiving first-line EGFR tyrosine kinase inhibitor: a meta-analysis of prospective randomized trials.
- Author(s)
  Hasegawa Y, Ando M, Maemondo M, Yamamoto S, Isa S, Saka H, Kubo A, Kawaguchi T, Takada M, Kurata T, Ou SH.
- Organizer
  Annual Meeting of the American Society of Clinical Oncology
- Place of Presentation
  Chicago, IL, USA.
- Year and Date
  2014-05-30 – 2014-06-03
- Data Source
  KAKENHI-PROJECT-23501314

1. KAWAHARA Masaaki (30344352)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. OKADA Masaji (40160684)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. FUKUOKA Junya (00324575)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. KUBO Akihito (60416245)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
5. KOU Yasuhiro (80426519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KAWAGUCHI Tomoya (70254422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
7. ISA Shun-Ichi (60421913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
8. SASAKI Hidefumi (00336695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OKAMOTO Isamu (10411597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

TAKADA Minoru 高田 實

Research Projects

Research Products

Co-Researchers

Nobel pharmacodynamics evaluation of molecular targeting agents: PHarmacokinetic/PHarmacodynamic Assessment on Malignant Effusions (PHAME)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of cytotoxic effect of human Granulysin by using novel PK/PD model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the relationship between EGFR gene status and clinical effect and the elucidation of the resistance mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The role of smoking status on the progression-free survival of non-small-cell lung cancer patients harboring activating epidermal growth factor (EGFR) mutations receiving first-line EGFR tyrosine kinase inhibitor: a meta-analysis of prospective randomized trials.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of consolidation chemotherapy after concurrent chemo-radiotherapy in locally advanced non-small-cell lung cancer.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-term complete response in a patient with disseminated pulmonary pleomorphic carcinoma induced by cisplatin and gemcitabine.2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Randomized phase III trial of erlotinib versus docetaxel as second- or third-line therapy in patients with advanced non-small cell lung cancer: Docetaxel and Erlotinib Lung cancer TriAl (DELTA).2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human papilloma virus in non-small cell lung cancer in never smokers: A systematic review of the literature.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Randomized phase III trial of erlotinib versus docetaxel as second- or third-line therapy in patients with advanced non-small cell lung cancer: Docetaxel and Erlotinib Lung cancer TriAl (DELTA).2014

Author(s)

Journal Title

Data Source

[Journal Article] Long-term Complete Response in a Patient with Disseminated Pulmonary Pleomorphic Carcinoma Induced by Cisplatin and Gemcitabine2014

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Is Consolidation Chemotherapy after Concurrent Chemo-Radiotherapy Beneficial for Patients with Locally Advanced Non-Small-Cell Lung Cancer?: A Pooled Analysis of the Literature.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential constitutive activation of the Epidermal Growth Factor Receptor (EGFR) in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] EGFR変異とゲフィチニブの臨床効果が相関しなかった1例2005

Author(s)

Journal Title

Data Source

[Journal Article] EGFR変異とゲフィチニブの臨床効果が相関しなかった1例2005

Author(s)

Journal Title

Description

Data Source

Author(s)

Organizer

TAKADA Minoru 高田實