WATANABE Kozo 渡辺幸造

Researcher Number	20376718
Affiliation (based on the past Project Information) *help	2014: 東京医科歯科大学, 難治疾患研究所免疫疾患分野, 助教 2007 – 2012: Laboratory of Immunology, Medical Research Institute, 難治疾患研究所, Assistant Professor 2006: 東京医科歯科大学, 難治疾忠研究所, 助教
Review Section/Research Field	Principal Investigator Immunology Except Principal Investigator Immunology / General medical chemistry
Keywords	Principal Investigator Bリンパ球 / 糖鎖 / レクチン / 糖鎖リガンド / Cタイプ様レクチン / CD72 / 免疫寛容・自己免疫 / 自己免疫 / 免疫寛容 Except Principal Investigator CD72 … More / CD22 / SARS / Bリンパ球 / ER stress / alternative splicing / infectious diseases / B lymphocyte / polymorphism / ハプロタイプ / 多型 / CD7 2 / 小胞体ストレス / 選択的スプライシング / 感染症 / 遺伝子多型 / スルファチド / ヘパリン / Sm/RNP / 自己抗体 / シグナル伝達 / Ｓｍ／ＲＮＰ / 硫酸化糖鎖 / 抑制性受容体 / 糖鎖 / レクチン / Bリンパ球、 Less

Carbohydrate recognition of B lymphocyte lectins and their function
- Principal Investigator
  
  TSUBATA Takeshi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University
Suppression of autoimmunity by B lymphocyte membrane protein CD72Principal Investigator
- Principal Investigator
  
  WATANABE Kozo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
Regulation of autoimmunity by B lymphocyte coreceptor CD72Principal Investigator
- Principal Investigator
  
  WATANABE Kozo
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
Immunogenetic analysis of the resistance to infectious diseases
- Principal Investigator
  
  TSUBATA Takeshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University

All 2011 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] Self-and non-self recognition by coreceptors on B lymphocytes : Regulation of B lymphocytes by CD19, CD21, CD22 and CD72.(D Kitamura, editor.)(How the Immune System Recognizes Self and Nonself)Chapter 72008
- Author(s)
  Watanabe, K., Tsubata,T
- Publisher
  Springer-Verlag Tokyo, Inc.
- Data Source
  KAKENHI-PROJECT-20790371
[Journal Article] CD22-Antagonists with nanomolar potency : The synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold2011
- Author(s)
  Abdu-Allah, H.H.M., Watanabe, K., Completo, G.C., Sadagopan, M., Hayashizaki, K., Takaku, C., Tamanaka, T., Takematsu, H., Kozutsumi, Y., Paulson, J.C., Tsubata, T., Ando, H., Ishida, H., Kiso, M.
- Journal Title
  
  Bioorg.Med.Chem
  
  Volume: 19 Issue: 6 Pages: 1966-1971
- DOI
  10.1016/j.bmc.2011.01.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21603007, KAKENHI-PROJECT-22380067, KAKENHI-PROJECT-22658038, KAKENHI-PUBLICLY-23113709, KAKENHI-PROJECT-23790531
[Journal Article] Design and synthesis of multivalent heterobifunctional CD22-ligand as a potential immunomodulator.2011
- Author(s)
  Abdu-Allah, H. H. M, Watanabe, K., Kanie, O., Tsubata, T. Ishida, H. and Kiso, M.
- Journal Title
  
  Synthesis
  
  Volume: 18 Pages: 2968-2974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390063
[Journal Article] CD22-antagonists with nanomolar potency: The synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold.2011
- Author(s)
  Abdu-Allah, H. H. M., Watanabe, K., Completo, G. C., Sadagopan, M., Hayashizaki, K., Takaku, C., Tamanaka, T., Takematsu, H., Kozutsumi, Y., Paulson, J.C., Tsubata, T., Ando, H., Ishida, H. and Kiso, M.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 19 Pages: 1966-1971
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790531
[Journal Article] Design and synthesis of multivalent heterobifunctional CD22-ligand as a potential immunomodulator.2011
- Author(s)
  Abdu-Allah, H. H. M., Watanabe, K., Kanie, O., Tsubata, T. Ishida, H. and Kiso, M.
- Journal Title
  
  Synthesis.
  
  Volume: 18 Pages: 2968-2974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790531
[Journal Article] Cationic nanogels efficiently deliver proteins to myeloma cells and primary T lymphocytes poorly expressing heparan sulfate2011
- Author(s)
  K.Watanabe, et al
- Journal Title
  
  Biomaterials
  
  Volume: 32 Issue: 25 Pages: 5900-5905
- DOI
  10.1016/j.biomaterials.2011.04.058
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114009, KAKENHI-PUBLICLY-23113709, KAKENHI-PROJECT-23390063, KAKENHI-PROJECT-23790531
[Journal Article] Design and synthesis of a multivalent heterobifunctional CD22 ligand as apotential immunomodulator2011
- Author(s)
  Abdu-Allah, H.H.M., Watanabe, K., Daikoku, S., Kanie, O., Tsubata, T., Ando, H., Ishida, H., Kiso, M.
- Journal Title
  
  Synthesis
  
  Volume: 18 Issue: 18 Pages: 2968-2974
- DOI
  10.1055/s-0030-1260151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21603007, KAKENHI-PROJECT-22380067, KAKENHI-PROJECT-22658038, KAKENHI-PROJECT-23790531
[Journal Article] The use of cationic nanogels to deliver proteins to myeloma cells and primary T lymphocytes that poorly express heparan sulfate.2011
- Author(s)
  Watanabe, K., Tsuchiya, Y., Kawaguchi, Y., Sawada, S., Ayame, H., Akiyoshi, K. and Tsubata, T.
- Journal Title
  
  Biomaterials.
  
  Volume: 32 Pages: 5900-5905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790531
[Journal Article] CD22-Antagonists with nanomolar potency : The synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold2011
- Author(s)
  Hajjaj H.M.Abdu-Allah, Kozo Watanabe, Gladys C.Completo, Magesh Sadagopan, Koji Hayashizaki, Chiaki Takaku, Taichi Tamanaka, Hiromu Takematsu, Yasunori Kozutsumi, James C.Paulson, Takeshi Tsubata, Hiromune Ando, Hideharu Ishida, Makoto Kiso
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 19 Pages: 1966-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790371
[Journal Article] CD22-Antagonists with nanomolar potency : The synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold2011
- Author(s)
  Hajjaj H.M. Abdu-Allah, Kozo Watanabe, Gladys C. Completo, Magesh Sadagopan, Koji Hayashizaki, Chiaki Takaku, Taichi Tamanaka, Hiromu Takematsu, Yasunori Kozutsumi, James C. Paulson, Takeshi Tsubata, Hiromune Ando, Hideharu Ishida, Makoto Kiso
- Journal Title
  
  Bioorg.Med.Chem. 19
  
  Pages: 1966-1971
- Data Source
  KAKENHI-PROJECT-20790371
[Journal Article] Synthesis of biotinylated sialoside to probe CD22-ligand interactions2009
- Author(s)
  Abdu-Allah, H.H.M., Watanabe, K., Hayashizaki, K., Iwayama, Y., Takematsu, H., Kozutsumi, Y., Tsubata, T., Ishida, H., Kiso, M.
- Journal Title
  
  Tetrahedron Lett. 50
  
  Pages: 4488-4491
- Data Source
  KAKENHI-PROJECT-20790371
[Journal Article] Autophagy connects antigen receptor signaling to costimulatory signaling in B lymphocytes2009
- Author(s)
  Watanabe K and Tsubata T
- Journal Title
  
  Autophagy 5
  
  Pages: 108-110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790371
[Journal Article] Potent Small Molecule Mouse CD22 Inhibitors: Exploring the Interaction of the Residue at C-2 of Sialic Acid Scaffold Bioorg.2009
- Author(s)
  Abdu-Allah, H.H.M., Watanabe, K., Hayashizaki, K., Takaku, C., Tamanaka, T., Takematsu, H., Kozutsumi, Y., Tsubata, T., Ishida, H., Kiso, M.
- Journal Title
  
  Med.Chem.Lett. 19
  
  Pages: 5573-5575
- Data Source
  KAKENHI-PROJECT-20790371
[Journal Article] Autophagy connects antigen receptor signaling2009
- Author(s)
  Watanabe, K., Tsubata, T.
- Journal Title
  
  Autophagy 5
  
  Pages: 108-110
- Data Source
  KAKENHI-PROJECT-20790371
[Journal Article] Potent Small Molecule Mouse CD22 Inhibitors : Exploring the Interaction of the Residue at C-2 of Sialic Acid Scaffold2009
- Author(s)
  Abdu-Allah, H.H.M., Watanabe, K., Hayashizaki, K, Takaku, C., Tamanaka, T., Takematsu, H, Kozutsumi, Y., Tsubata, T., Ishida, H., Kiso, M.
- Journal Title
  
  Bioorg.Med.Chem.Lett
  
  Volume: 19 Pages: 5573-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790371
[Journal Article] Synthesis of biotinylated sialoside to probe CD22-ligand interactions2009
- Author(s)
  Abdu-Allah, H.H.M., Watanabe, K., Hayashizaki, K., Iwayama, Y., Takematsu, H., Kozutsumi, Y., Tsubata, T., Ishida, H., Kiso, M.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 50 Pages: 5573-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790371
[Journal Article] Induction of autophagy by B cell antigen receptor stimulation and its inhibition by costimulation2008
- Author(s)
  Watanabe K, Ichinose S, Hayashizaki K and Tsubata T
- Journal Title
  
  Biochem Biophys Res Coommun 374
  
  Pages: 274-281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790371
[Journal Article] Induction of autophagy by B cell antigen receptor stimulation and its inhibition by costimulation2008
- Author(s)
  Watanabe, K., Ichinose, S., Hayashizaki, K., Tsubata,T.
- Journal Title
  
  Biochem Biophys Res Commun. 374(2)
  
  Pages: 274-281
- Data Source
  KAKENHI-PROJECT-20790371
[Journal Article] Induction of autophagy by B cell antigen receptor stimulation and its inhibition by costimulation.2007
- Author(s)
  Watanabe, K., Ichinose, S., Hayashizaki, K., Tsubata, T.
- Journal Title
  
  Biochem. Biophys. Res. Comm. 374
  
  Pages: 274-281
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18406019
[Journal Article] Induction of autophagy by B cell antigen receptor stimulation and its inhibition by costimulation2007
- Author(s)
  Watanabe, K., Ichinose, S., Hayashizaki, K., Tsubata, T
- Journal Title
  
  Biochem. Biophys. Res. Comm. 374
  
  Pages: 274-281
- Data Source
  KAKENHI-PROJECT-18406019
[Journal Article] Autophagy connects antigen receptor signaling to costimulatory signaling in B lymphocytes2007
- Author(s)
  Watanabe, K, Tsubata, T.
- Journal Title
  
  Autophagy 5
  
  Pages: 108-110
- Data Source
  KAKENHI-PROJECT-18406019
[Journal Article] Autophagy connects antigen receptor signaling to costimulatory signaling in B lymphocytes.2007
- Author(s)
  Watanabe, K, Tsubata, T.
- Journal Title
  
  Autophagy. 5
  
  Pages: 108-110
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18406019
[Journal Article] The use of cationic nanogels to deliver proteins to myeloma cells and primary T lymphocytes that poorly express heparan sulfate
- Author(s)
  Kozo Watanabe, Yumiko Tsuchiya, Yoshinori Kawaguchi, Shin-ichi Sawada, Hirohito Ayame, Kazunari Akiyoshi, Takeshi Tsubata
- Journal Title
  
  Biomaterials. in press
- Data Source
  KAKENHI-PROJECT-20790371
[Presentation] The C-type lectin-like domain containing B lymphocyte membrane molecule CD72 shows Ca2 ＋-independent lectin activity to sulfated glycans2011
- Author(s)
  渡辺幸造、安達貴弘、鍔田武志
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-23390063
[Presentation] 合成ビオチン化CD22リガンドを用いた競合阻害ELISAによる新規合成CD22リガンドの活性評価2009
- Author(s)
  渡辺幸造、竹松弘、鍔田武志
- Organizer
  日本免疫学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790371
[Presentation] CHP-NH2 ナノゲルを用いたタンパク導入によるがん細胞とT細胞の細胞死制御2009
- Author(s)
  渡辺幸造、土屋祐美子、河口佳典、菖蒲弘人、澤田晋一、秋吉一成、鍔田武志
- Organizer
  ケミカルバイオロジー学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20790371
[Presentation] The C-type lectin-like domain-containing B lymphocyte membrane molecule CD72 carries a Ca2+-independent2009
- Author(s)
  Kozo Watanabe, Kenichi Nakajima, Yuka Imai, Motohiko Sato, Koji Hayashizaki, Takahiro Adachi, Kiichiro Totani, Yukishige Ito, Takeshi Tsubata
- Organizer
  lectin activity to oligomannose CREST国際シンポジウム
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-20790371
[Presentation] 合成ビオチン化CD22リガンドを用いた競合阻害ELISAによる新規合成CD22リガンドの活性評価2009
- Author(s)
  渡辺幸造、竹松弘、鍔田武志
- Organizer
  日本免疫学会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20790371
[Presentation] CHP-NH2ナノゲルを用いたタンパク導入によるがん細胞とT細胞の細胞死制御2009
- Author(s)
  渡辺幸造、土屋祐美子、河口佳典、菖蒲弘人、澤田晋一、秋吉一成、鍔田武志
- Organizer
  ケミカルバイオロジー学会
- Place of Presentation
  神戸
- Year and Date
  2009-05-19
- Data Source
  KAKENHI-PROJECT-20790371
[Presentation] B細胞特異的C型レクチン様分子CD72はオリゴマンノースに対してCa2+非依存性のレクチン活性を有する2008
- Author(s)
  渡辺幸造, 中島権一, 今井有香, 安達貴弘,佐藤元彦, 林崎浩史, 戸谷希一郎, 伊藤幸成, 鍔田武志
- Organizer
  日本分子生物学会年会・日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20790371
[Presentation] B細胞特異的C型レクチン様分子CD72のオリゴマンノースに対するCa2+非依存性のレクチン活性2008
- Author(s)
  渡辺幸造, 安達貴弘, 鍔田武志
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18406019
[Presentation] Ca2+-independent lectin activity of C-type lectin-like domain-containing B lymphocyte membrane molecule CD72 for oligomannose2008
- Author(s)
  Kozo Watanabe, Kenichi Nakajima Youka Imai, Takahiro Adachi,Motohiko Sato, Koji Hayashizaki, Kiichiro Totani, Yukishige Ito and Takeshi Tsubata
- Organizer
  日本分子生物学会・生化学会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20790371
[Presentation] B細胞特異的C型レクチン様分子CD72はオリゴマンノースに対してCa2+非依存性のレクチン活性を有する2008
- Author(s)
  渡辺幸造, 中島権一, 今井有香, 安達貴弘, 佐藤元彦, 林崎浩史, 戸谷希一郎, 伊藤幸成, 鍔田武志
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18406019
[Presentation] B細胞特異的C型レクチン様分子CD72ほオリゴマンノースに対してCa2+非依存性のレクチン活性を有する2008
- Author(s)
  渡辺幸造, 中島権一, 今井有香, 安達貴弘, 佐藤元彦, 林崎浩史, 戸谷希一郎, 伊藤幸成, 鍔田武志
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-18406019
[Presentation] B細胞特異的C型レクチン様分子CD72のオリゴマンノースに対するCa2+非依存性のレクチン活性2008
- Author(s)
  渡辺幸造, 安達貴弘, 鍔田武志
- Organizer
  日本免疫学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790371
[Presentation] The C-type lectin-like domain-containing B lymphocyte membrane molecule CD72 carries a Ca2+-independent lectin activity to oligomannose2008
- Author(s)
  Watanabe Kozo, Adachi Takahiro and Tsubata Takeshi
- Organizer
  日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-20790371

1. TSUBATA Takeshi (80197756)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. ITO Nobutoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 石田秀治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

WATANABE Kozo 渡辺 幸造

Research Projects

Research Products

Co-Researchers

Carbohydrate recognition of B lymphocyte lectins and their function

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Suppression of autoimmunity by B lymphocyte membrane protein CD72Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of autoimmunity by B lymphocyte coreceptor CD72Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immunogenetic analysis of the resistance to infectious diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Self-and non-self recognition by coreceptors on B lymphocytes : Regulation of B lymphocytes by CD19, CD21, CD22 and CD72.(D Kitamura, editor.)(How the Immune System Recognizes Self and Nonself)Chapter 72008

Author(s)

Publisher

Data Source

[Journal Article] CD22-Antagonists with nanomolar potency : The synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design and synthesis of multivalent heterobifunctional CD22-ligand as a potential immunomodulator.2011

Author(s)

Journal Title

Data Source

[Journal Article] CD22-antagonists with nanomolar potency: The synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold.2011

Author(s)

Journal Title

Data Source

[Journal Article] Design and synthesis of multivalent heterobifunctional CD22-ligand as a potential immunomodulator.2011

Author(s)

Journal Title

Data Source

[Journal Article] Cationic nanogels efficiently deliver proteins to myeloma cells and primary T lymphocytes poorly expressing heparan sulfate2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design and synthesis of a multivalent heterobifunctional CD22 ligand as apotential immunomodulator2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The use of cationic nanogels to deliver proteins to myeloma cells and primary T lymphocytes that poorly express heparan sulfate.2011

Author(s)

Journal Title

Data Source

[Journal Article] CD22-Antagonists with nanomolar potency : The synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold2011

Author(s)

Journal Title

Data Source

[Journal Article] CD22-Antagonists with nanomolar potency : The synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold2011

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of biotinylated sialoside to probe CD22-ligand interactions2009

Author(s)

Journal Title

Data Source

[Journal Article] Autophagy connects antigen receptor signaling to costimulatory signaling in B lymphocytes2009

Author(s)

Journal Title

Data Source

[Journal Article] Potent Small Molecule Mouse CD22 Inhibitors: Exploring the Interaction of the Residue at C-2 of Sialic Acid Scaffold Bioorg.2009

WATANABE Kozo 渡辺幸造