Nagata Kohzo 永田浩三

… Alternative Names

NAGATA Kohzo 永田浩三

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Researcher Number	20378227
Other IDs
Affiliation (Current)	2025: 名古屋大学, 医学系研究科(保健), 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 名古屋大学, 医学系研究科(保健), 教授 2012 – 2013: 名古屋大学, 医学(系)研究科(研究院), 教授 2008: Nagoya University, 医学部・保健学科, 准教授 2007 – 2008: Nagoya University, 医学部, 准教授 2007: Nagoya University, School of Medicine, Assistant Professor 2005 – 2006: 名古屋大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Laboratory medicine / Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Hygiene
Keywords	Principal Investigator 高血圧 / 心筋傷害 / メタボリックシンドローム / アミノ酸 / 心筋 / ミトコンドリア / L-アルギニン / 脂肪病態 / ミトコンドリア抗酸化薬 / ミトコンドリア機能・動態 … More / 心筋病態 / ミトコンドリア分裂阻害薬 / ミトコンドリア動態 / ミトコンドリア機能 / 炎症 / 酸化ストレス / グルココルチコイド / 脂肪組織 / 左室拡張障害 / 心筋リモデリング / メタボリック症候群 / 糖代謝異常 / 脂肪組織炎症 / βアドレナリン受容体 / グルココルチコイド受容体 / ストレス / 左室肥大 / 遺伝子発現 / アンジオテンシン / 心臓 / 拡張機能 / 心筋線維化 / 心筋肥大 / トランスジェニックマウス / ZAKI-4β … More Except Principal Investigator 心筋細胞 / 心筋リモデリング / 心不全 / Olmesartan / Cardiomyocyte / Heart Failure / Hypertension / Protease-Cathepsin S / Ventricular Remodeling / 蛋白質分解酵素-カテプシンS / オルメサルタン / 高血圧 / 蛋白分解酵素-カテプシンS / DNA Bank / Susceptibility Gene / Odds Ratio / Genome-Wide and Candidate Gene Association Study / Lifestyle Related-Disease / Cohort Study / King Study / Investigation of Genetic Risk of Cardiovascular Di / 症例-対照関連解 / KING study / 心筋梗塞 / DNAバンク / 疾患感受性遺伝子 / 遺伝子型頻度 / 症例-対照関連解析 / 生活習慣病 / コホート研究 / KING Study / 北名古屋ゲノム疫学研究 / 心臓ラプチャー / カテプシン / ドブタミン負荷試験 / 心筋症 / 機能性RNA / 心臓病態学 Less

Amino acid intervention in metabolic syndrome: analysis of cardiac mitochondrial function and dynamicsPrincipal Investigator
- Principal Investigator
  
  Nagata Kohzo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Nagoya University
Roles of glucocorticoid receptors in cardiac and adipose tissue pathology in a rat model of metabolic syndromePrincipal Investigator
- Principal Investigator
  
  NAGATA Kohzo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagoya University
To detect non-coding RNA related to heart failure
- Principal Investigator
  
  HIDEO Izawa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fujita Health University
  Nagoya University
Clarification of regulatory mechanisms for myocardial remodeling in cardiac-specific overexpression of ZAKI-4β in micePrincipal Investigator
- Principal Investigator
  
  NAGATA Kohzo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
DEFICIENCY OF CATHEPSIN S IMPROVE CARDIAC REMODELING AND FUNCTION AFTER MTOCARDIAL INFARCTION IN THE MOUSE HEART
- Principal Investigator
  
  CHENG Xian Wu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
Population based study of genetic risk and gene-environment interaction in lifestyle-related diseases including coronary artery diseases(KING Study)
- Principal Investigator
  
  YOKOTA Mitsuhiro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hygiene
- Research Institution
  Aichi Gakuin University
  Nagoya University
The Role for Cysteine Protease Cathepsin in Left Ventricular Remodeling and Gene Therapy Application.
- Principal Investigator
  
  CHENG Xianwu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University

All 2024 2023 2022 2014 2013 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment2008
- Author(s)
  Cheng XW, Murohara T, Kuzuya M, Izawa H, Sasaki T, Obata K, Nagata K, Nishizawa T, Kobayashi M, Yamada T, Kim W, Sato K, Shi GP, Okumura K, Yokota M.
- Journal Title
  
  Am J Pathol 173(2)
  
  Pages: 358-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590808
[Journal Article] Dobutamine stress testing as a diagnostic tool for evaluation of myocardial contractiMle reserve in asymptomatic or mildly symptomatic patients with dilated cardiomyopathy2008
- Author(s)
  Kobayashi M, Izawa H, Cheng XW, Asano H, Hirashiki A, Unno K, Ohshima S, Yamada T, Murase Y, Kato TS, Obata K, Noda A, Nishizawa T, Isobe S, Nagata K, Matsubara T, urohara T, Yokota M.
- Journal Title
  
  JACC Cardiovasc Imaging 1(6)
  
  Pages: 718-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590808
[Journal Article] Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure.2006
- Author(s)
  Saka M, Obata K, Ichihara S, Cheng XW, Kimata H, Takao N, Noda K, Izawa H, Nagata K, Murohara T, Yokota M.
- Journal Title
  
  Journal of Cardiovascular Pharmacology 47
  
  Pages: 770-779
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590719
[Journal Article] A Elastolytic Cathepsin Induction/Activation System Exists in the Rat and Human Myocardium and is Upregulated in Hypertensive Heart Failure.2006
- Author(s)
  Cheng XW, Obata K, Kzuya M, Izawa H, Nakamura K, Asahi E, Saka M, Kimata T, Nagasaka T, Noda A, Nagata K, Jin H, Shi G P, Iguchi A, Murohara T, Yokota M
- Journal Title
  
  Hypertension 48
  
  Pages: 979-987
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590719
[Journal Article] A Elastolytic Cathepsin Induction/Activation System Exists in the Rat and Human Myocardium and is Upregulated in Hypertensive Heart Failure.2006
- Author(s)
  Cheng XW, Obata K, Kzuya M, Izawa H, Nakamura K, Asahi E, Saka M, Kimata T, Nagasaka T, Noda A, Nagata K, Jin H, Shi GP, Iguchi A, Murohara T, Yokota M
- Journal Title
  
  Hypertension 48
  
  Pages: 979-987
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590719
[Journal Article] Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure.2006
- Author(s)
  Saka M, Obata K, Ichihara S, Cheng XW, Kimata H, Takao Nishizawa, Noda K, Izawa H, Nagata K, Murohara T, Yokota M
- Journal Title
  
  Journal of Cardiovascular Pharmacology 47
  
  Pages: 770-779
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590719
[Journal Article] Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin : potential role of the RhoA-ERK-SRF signaling pathway.2006
- Author(s)
  Saka M, Obata K, Ichihara S, Chene XW, Kimata H, Noda K, Nagata K, Yokota M.
- Journal Title
  
  Clinical and Experimental Pharmacology and Physiology 33
  
  Pages: 1164-1171
- Data Source
  KAKENHI-PROJECT-17590719
[Journal Article] Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats.2006
- Author(s)
  Kohzo Nagata
- Journal Title
  
  Hypertension 47
  
  Pages: 656-654
- NAID
  130004245524
- Data Source
  KAKENHI-PROJECT-17209021
[Journal Article] Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin : potential role of the RhoA-ERK-SRF signaling pathway.2006
- Author(s)
  Saka M, Obata K, Ichihara S, Cheng XW, Kimata H, Noda K, Nagata K, Yokota M
- Journal Title
  
  Clinical and Experimental Pharmacology and Physiology 33
  
  Pages: 1164-1171
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590719
[Journal Article] Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure.2006
- Author(s)
  Saka M, Obata K, Ichihara S, Cheng XW, Kimata H, Takao Nishizawa, Noda K, Izawa H, Nagata K, Murohara T, Yokota M.
- Journal Title
  
  Journal of Cardiovascular Pharmacology 47
  
  Pages: 770-779
- Data Source
  KAKENHI-PROJECT-17590719
[Journal Article] Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats.
- Author(s)
  Kohzo Nagata
- Journal Title
  
  Hypertension (in press)
- NAID
  130004245524
- Data Source
  KAKENHI-PROJECT-17209021
[Presentation] Mdivi-1, a mitochondrial fission inhibitor, ameliorates cardiac fibrosis and diastolic dysfunction, but not hypertension, in rats with metabolic syndrome2024
- Author(s)
  吉田恵輔、三島凜、田上海斗、奥澤透子、岩田晃陽、池田勝秀、室原豊明、永田浩三
- Organizer
  第88回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08078
[Presentation] The mitochondria-targeted antioxidant mitoquinol ameliorates cardiac fibrosis and diastolic dysfunction in rats with metabolic syndrome2023
- Author(s)
  奥澤透子、田上海斗、寺西環海、小原菜月、國松明日子、小出眞弥子、池田勝秀、室原豊明、永田浩三
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08078
[Presentation] L-arginine supplementation substantially ameliorates hypertension but does not improve LV hypertrophy, inflammation, fibrosis, or diastolic dysfunction in metabolic syndrome rats2022
- Author(s)
  早川美咲、崔茜茜、古川希、磯貝千遥、奥澤透子、城田紗希、田上海斗、坂部名奈子、池田勝秀、永田浩三（代理発表者）
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08078
[Presentation] Restraint stress attenuates obesity and deteriorates cardiac and adipose tissue pathology via β-adrenergic receptors in rats with metabolic syndrome2014
- Author(s)
  Natsumi Matsuura, Kai Nagasawa, Yuji Minagawa, Sae Ohura, Yuuri Takeshita, Takuya Hattori, Shogo Watanabe, Toyoaki Murohara, Kohzo Nagata
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590690
[Presentation] Glucocorticoid receptor blockade ameliorates cold stress-induced exacerbation of cardiac and adipose tissue pathology in a rat model of metabolic syndrome2014
- Author(s)
  Kai Nagasawa, Natsumi Matsuura, Yuji Minagawa, Yuuri Takeshita, Sae Ohura, Takuya Hattori, Shogo Watanabe, Toyoaki Murohara, Kohzo Nagata
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590690
[Presentation] Restraint stress attenuates obesity and deteriorates cardiac and adipose tissue pathology viaβ-adrenergic receptors in rats with metabolic syndrome2014
- Author(s)
  Natsumi Matsuura, Kai Nagasawa, Yuji Minagawa, Sae Ohura, Yuuri Takeshita, Takuya Hattori, Shogo Watanabe, Toyoaki Murohara, Kohzo Nagata
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590690
[Presentation] RU486を用いたグルココルチコイド受容体遮断はメタボリックシンドロームラットの脂肪組織炎症と心筋傷害を軽減する2013
- Author(s)
  竹下侑里、高橋圭司、大浦彩依、松浦菜摘、長澤快、服部拓哉、渡辺彰吾、伊藤裕美、室原豊明、永田浩三
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24590690
[Presentation] Cardiac-Specific Overexpression of ZAKI-4β Attenuates LV Hypertrophy and Interstitial Fibrosis, but not Coronary Perivascular Fibrosis, Induced by Angiotensin II2007
- Author(s)
  西澤孝夫、小畑孝二、永田浩三、野田明子、成憲武、井澤英夫、横田充弘、室原豊明
- Organizer
  第71回日本循環器学会総会・学術集会
- Place of Presentation
  神戸
- Year and Date
  2007-03-17
- Data Source
  KAKENHI-PROJECT-19590809
[Presentation] Cardiac-specific overexpression of ZAKI-4βattenuates LV hypertrophy and interstitial fibrosis, but not coronary perivascular fibrosis, induced by angiotensin II.2007
- Author(s)
  Nishizawa T, Nagata K, Noda A, Cheng XW, Izawa H, Yokota M, et al
- Organizer
  第71回日本循環器学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19590809

1. HIDEO Izawa (80402569)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
2. YOKOTA Mitsuhiro (50201851)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
3. CHENG Xian Wu (30378228)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
4. NODA Akiko (80252287)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
5. KUZUYA Masafumi (10283441)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MUROHARA Yotoaki (90299503)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. HASHIMOTO Katsunori (70324423)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OKUMURA Kenji (40262901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKESHITA Kyousuke (70444403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. UEYAMA Jun (00397465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ITO Hiromi (20610752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. OBATA Koji (40378229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KONDO Takahisa (00303644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. IGUCHI Aakihisa (20109763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Nagata Kohzo 永田 浩三

NAGATA Kohzo 永田 浩三

Research Projects

Research Products

Co-Researchers

Amino acid intervention in metabolic syndrome: analysis of cardiac mitochondrial function and dynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of glucocorticoid receptors in cardiac and adipose tissue pathology in a rat model of metabolic syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

To detect non-coding RNA related to heart failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of regulatory mechanisms for myocardial remodeling in cardiac-specific overexpression of ZAKI-4β in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEFICIENCY OF CATHEPSIN S IMPROVE CARDIAC REMODELING AND FUNCTION AFTER MTOCARDIAL INFARCTION IN THE MOUSE HEART

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Population based study of genetic risk and gene-environment interaction in lifestyle-related diseases including coronary artery diseases(KING Study)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Role for Cysteine Protease Cathepsin in Left Ventricular Remodeling and Gene Therapy Application.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment2008

Author(s)

Journal Title

Data Source

[Journal Article] Dobutamine stress testing as a diagnostic tool for evaluation of myocardial contractiMle reserve in asymptomatic or mildly symptomatic patients with dilated cardiomyopathy2008

Author(s)

Journal Title

Data Source

[Journal Article] Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] A Elastolytic Cathepsin Induction/Activation System Exists in the Rat and Human Myocardium and is Upregulated in Hypertensive Heart Failure.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] A Elastolytic Cathepsin Induction/Activation System Exists in the Rat and Human Myocardium and is Upregulated in Hypertensive Heart Failure.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin : potential role of the RhoA-ERK-SRF signaling pathway.2006

Author(s)

Journal Title

Data Source

[Journal Article] Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats.2006

Nagata Kohzo 永田浩三

NAGATA Kohzo 永田浩三