Koinuma Koji 鯉沼広治

… Alternative Names

鯉沼広治コイヌマコウジ

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Researcher Number	20382905
Other IDs
Affiliation (Current)	2025: 自治医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 自治医科大学, 医学部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Digestive surgery
Keywords	Principal Investigator メトホルミン / 転移 / 発癌 / 糖尿病 / 多重免疫染色 / 腫瘍浸潤リンパ球 / 好中球細胞外トラップ / 免疫 / 大腸癌 / アデノシン … More / Abscopal Effect / 肺転移 / Abscopal Effect / 免疫放射線療法 / 直腸癌 … More Except Principal Investigator 核酸医薬 / マイクロRNA / 腹膜播種 / 小腸大腸肛門外科学 / 消化器外科学 / 癌 / LuM1 / 免疫放射線療法 / abscopal effect / 免疫療法 / アデノシン / 放射線療法 / Abscopal effect / 接着 / CD73 / 放射線治療 / 肺転移 / 直腸癌 Less

Role of neutrophil extracellular traps in the pathophysiology of colorectal cancerPrincipal Investigator
- Principal Investigator
  
  鯉沼広治
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jichi Medical University
Novel method to prevent peritoneal recurrence using nuclear medicine
- Principal Investigator
  
  Ohzawa Hideyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Jichi Medical University
Novel radioimmunotherapy for rectal cancer based on the tumor metabolismPrincipal Investigator
- Principal Investigator
  
  Koinuma Koji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jichi Medical University
Radiation and immune checkpoint inhibition for the treatment of advanced rectal cancer with distant micrometastasis
- Principal Investigator
  
  Horie Hisanaga
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Jichi Medical University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Metformin may improve the outcome of patients with colorectal cancer and type 2 diabetes mellitus partly through effects on neutrophil extracellular traps.2023
- Author(s)
  Saito A, Koinuma K, Kawashima R, Miyato H, Ohzawa H, Horie H, Yamaguchi H, Kawahira H, Mimura T, Kitayama J, Sata N.
- Journal Title
  
  BJC Reports
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08901
[Journal Article] The Regional Specificity of Mucosa-Associated Microbiota in Patients with Distal Colorectal Cancer2022
- Author(s)
  Kono Yoshihiko、Inoue Ryo、Teratani Takumi、Tojo Mineyuki、Kumagai Yuko、Morishima So、Koinuma Koji、Lefor Alan Kawarai、Kitayama Joji、Sata Naohiro、Horie Hisanaga
- Journal Title
  
  Digestion
  
  Volume: 103 Issue: 2 Pages: 141-149
- DOI
  10.1159/000519487
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08901, KAKENHI-PROJECT-22K16543, KAKENHI-PROJECT-21K20958
[Journal Article] Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model2022
- Author(s)
  Tojo Mineyuki、Miyato Hideyo、Koinuma Koji、Horie Hisanaga、Tsukui Hidenori、Kimura Yuki、Kaneko Yuki、Ohzawa Hideyuki、Yamaguchi Hironori、Yoshimura Kotaro、Lefor Alan Kawarai、Sata Naohiro、Kitayama Joji
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1
- DOI
  10.1038/s41598-022-11236-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08901, KAKENHI-PROJECT-23K24411
[Journal Article] CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model2020
- Author(s)
  H. Tsukui, H. Horie, K. Koinuma, H. Ohzawa, Y. Sakuma, Y. Hosoya, H. Yamaguchi, K. Yoshimura, A. K. Lefor, N. Sata, J. Kitayama.
- Journal Title
  
  BMC Cancer
  
  Volume: 20(1) Issue: 1 Pages: 411-411
- DOI
  10.1186/s12885-020-06893-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09225
[Journal Article] CD73 Blockade Enhances the Local and Abscopal Effects of Radiotherapy in a Murine Rectal Cancer Model2020
- Author(s)
  Hidenori Tsukui, Hisanaga Horie, Koji Koinuma, Hideyuki Ohzawa, Yasunaru Sakuma, Yoshinori Hosoya, Hironori Yamaguchi, Kotaro Yoshimura, Alan Kawarai Lefor , Naohiro Sata , Joji Kitayama.
- Journal Title
  
  BMC Cancer
  
  Volume: 20 Pages: 411-411
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] 大腸癌患者の術後末梢血中低比重好中球と予後の関連性2022
- Author(s)
  風當ゆりえ, 北山丈二, 金子勇貴, 髙橋和也, 木村勇希, 太田学, 熊谷祐子, 太白健一, 直井大志, 佐田友藍, 井上賢之, 大澤英之, 宮戸秀世, 鯉沼広治, 佐久間康成, 堀江久永, 細谷好則,佐田尚宏
- Organizer
  第77回日本大腸肛門病学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08901
[Presentation] 大腸がん患者の術直後の血中低比重好中球比率が補助化学療法の再発予測因子となるか2022
- Author(s)
  風當ゆりえ, 北山丈二, 金子勇貴, 高橋和也, 木村有希, 熊谷祐子, 太白健一, 直井大志, 佐田友藍, 大澤英之, 宮戸秀世, 鯉沼広治, 堀江久永, 山口博紀,佐田尚宏
- Organizer
  第60回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08901
[Presentation] Expression of programmed cell death ligand 1 in peripheral blood monocytes is associated with the response to preoperative chemoradiotherapy for rectal cancer.2022
- Author(s)
  高橋礼, 東條峰之, 津久井秀則, 松宮美沙希, 金子勇貴, 風當ゆりえ, 木村有希, 髙橋和也, 大澤英之, 宮戸秀世, 鯉沼広治, 山口博紀, 佐久間康成, 川平洋, 堀江久永, 細谷好則, 味村俊樹, アラン瓦井レフォー, 北山丈二,佐田尚宏
- Organizer
  第26回日本外科病理学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08901
[Presentation] 直腸癌術前放射線化学療法の奏効率と末梢血単核球上PDL1との関連2021
- Author(s)
  東條峰之, 津久井秀則, 金子勇貴, 風當ゆりえ, 木村有希, 髙橋和也, 齋藤晶, 大澤英之, 宮戸秀世, 鯉沼広治, 堀江久永, 佐田尚宏，北山丈二
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09225
[Presentation] Combination therapy of local radiation and metformin can suppress the spontaneous lung metastases of murine tumor2020
- Author(s)
  東條峰之, 津久井秀則, 齋藤晶, 高橋和也, 木村有希, 熊谷祐子, 宮戸秀世, 大澤英之, 鯉沼広治, 堀江久永, 佐田尚宏, 北山丈二
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09225
[Presentation] 大腸癌細胞株LuM1肺転移モデルにおけるMetoformin併用放射線治療2020
- Author(s)
  東條峰之, 津久井秀則, 齋藤晶, 木村有希, 髙橋和也, 熊谷祐子, 金丸理人, 宮戸秀世, 大澤英之, 鯉沼広治, 佐田尚宏, 北山丈二
- Organizer
  第41回癌免疫外科研究会
- Data Source
  KAKENHI-PROJECT-19K09225
[Presentation] 直腸癌に対する術前CRTと選択的側方郭清併用による治療成績2020
- Author(s)
  堀江久永, 鯉沼広治, 巷野佳彦, 佐田友藍, 直井大志, 佐久間康成, 細谷好則, 味村俊樹, 北山丈二, 佐田尚宏
- Organizer
  第75回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-19K09225
[Presentation] CD73 targeting therapy enhances the antitumor effect of radiotherapy in rectal cancer2020
- Author(s)
  津久井秀則, 堀江久永, 大澤英之, 山口博紀, 佐久間康成, 川平洋, 細谷好則, 味村俊樹, 鯉沼広治, 吉村浩太郎, Alan Lefor, 佐田尚宏, 北山丈二
- Organizer
  第120回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09225
[Presentation] 術前CRTと側方郭清による側方リンパ節転移の制御．2019
- Author(s)
  堀江　久永，鯉沼　広治，井上　賢之，田原　真紀子，巷野　佳彦，佐久間　康成，細谷　好則，味村　俊樹，北山　丈二，佐田　尚宏．
- Organizer
  第74回日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-19K09225
[Presentation] 術前CRTと側方郭清による側方リンパ節転移の制御．2019
- Author(s)
  堀江　久永，鯉沼　広治，井上　賢之，田原　真紀子，巷野　佳彦，佐久間　康成，細谷　好則，味村　俊樹，北山　丈二，佐田　尚宏．
- Organizer
  第74回日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] 直腸癌術前化学放射線療法における治療前後末梢血好中球リンパ球による治療効果予測2018
- Author(s)
  津久井秀則, 北山丈二, 森本光昭, 熊谷祐子, 佐田友藍, 清水徹一郎, 直井大志, 田原真紀子, 巷野佳彦, 森和亮, 伊藤誉, 井上賢之, 鯉沼広治, 佐久間康成, 細谷好則, 堀江久永, Alan Lefor, 佐田尚宏
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] 当院における局所進行下部直腸癌に対する術前化学放射線療法の有用性と課題について2017
- Author(s)
  森本光昭,津久井秀則,熊谷祐子,佐田友藍,清水徹一郎,直井大志,田原真紀子,巷野佳彦,森和亮,伊藤誉,井上賢之,鯉沼広治,佐久間康成,細谷好則,北山丈二,堀江久永,Lefor Alan ,佐田尚宏
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10649
[Presentation] Local irradiation with systemic anti-PD1 antibody may effectively suppress the micrometastasis in distant organ through the induction of abscopal effects.2017
- Author(s)
  Hidenori Tsukui, Rihito Kanamaru, Ai Sadatomo, Daishi Naoi, Tetsuichiro Shimizu, Makiko Tahara, Katsusuke Mori, Homare Ito, Mitsuaki Morimoto, Yoshihiko Kono, Yoshiyuki Inoue, Hiroyuki Maruyama, Koji Koinuma, Hisanaga Horie, Yasunaru Sakuma, Yoshinori Hosoya, Naohiro Sata, Joji Kitayama.
- Organizer
  AACR 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10649

1. 北山丈二 (20251308)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
2. Horie Hisanaga (20316532)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
3. 井上賢之 (80375279)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. Ohzawa Hideyuki (60458271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 山口博紀 (20376445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 田原真紀子 (30406102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 佐田尚宏 (20261977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 宮戸秀世 (90813163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 佐田友藍 (40528585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 金丸理人 (10625544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Koinuma Koji 鯉沼 広治

鯉沼 広治 コイヌマ コウジ

Research Projects

Research Products

Co-Researchers

Role of neutrophil extracellular traps in the pathophysiology of colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel method to prevent peritoneal recurrence using nuclear medicine

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel radioimmunotherapy for rectal cancer based on the tumor metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Radiation and immune checkpoint inhibition for the treatment of advanced rectal cancer with distant micrometastasis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Metformin may improve the outcome of patients with colorectal cancer and type 2 diabetes mellitus partly through effects on neutrophil extracellular traps.2023

Author(s)

Journal Title

Data Source

[Journal Article] The Regional Specificity of Mucosa-Associated Microbiota in Patients with Distal Colorectal Cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD73 Blockade Enhances the Local and Abscopal Effects of Radiotherapy in a Murine Rectal Cancer Model2020

Author(s)

Journal Title

Data Source

[Presentation] 大腸癌患者の術後末梢血中低比重好中球と予後の関連性2022

Author(s)

Organizer

Data Source

[Presentation] 大腸がん患者の術直後の血中低比重好中球比率が補助化学療法の再発予測因子となるか2022

Author(s)

Organizer

Data Source

[Presentation] Expression of programmed cell death ligand 1 in peripheral blood monocytes is associated with the response to preoperative chemoradiotherapy for rectal cancer.2022

Author(s)

Organizer

Data Source

[Presentation] 直腸癌術前放射線化学療法の奏効率と末梢血単核球上PDL1との関連2021

Author(s)

Organizer

Data Source

[Presentation] Combination therapy of local radiation and metformin can suppress the spontaneous lung metastases of murine tumor2020

Author(s)

Organizer

Data Source

[Presentation] 大腸癌細胞株LuM1肺転移モデルにおけるMetoformin併用放射線治療2020

Author(s)

Organizer

Data Source

[Presentation] 直腸癌に対する術前CRTと選択的側方郭清併用による治療成績2020

Author(s)

Organizer

Data Source

Koinuma Koji 鯉沼広治

鯉沼広治コイヌマコウジ