Sakai Akihiro 酒井昭博

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Akihiro Sakai 酒井昭博

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Researcher Number	20384886
Other IDs
Affiliation (Current)	2025: 東海大学, 医学部, 客員准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 東海大学, 医学部, 准教授 2018: 東海大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator 扁平上皮癌 / RNA-Seq / CPSF1 / 頭頸部癌 / 選択的スプライシング / RNA-seq

頭頸部癌におけるスプライシング関連遺伝子CPSF1遺伝子異常による発癌機構の解明Principal Investigator
- Principal Investigator
  
  酒井昭博
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Tokai University
Exploring the mechanisms of carcinogenesis through the aberrant alternative splicing in head and neck cancerPrincipal Investigator
- Principal Investigator
  
  Akihiro Sakai
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Tokai University

All 2023 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Computed Tomography to Diagnose Paranasal Sinus Chemical Burns and Tissue Damage: A Case Report2021
- Author(s)
  Saito Kosuke、Goto Fumiyuki、Sekine Motoki、Yamamoto Hikaru、Kaneda Shoji、Sakai Akihiro、Ebisumoto Koji、Maki Daisuke、Iijima Hiroaki、Yamauchi Mayu、Watanabe Takane、Okami Kenji
- Journal Title
  
  The Laryngoscope
  
  Volume: 2 Issue: 9 Pages: 1-2
- DOI
  10.1002/lary.29408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16860
[Journal Article] Predicting the radiosensitivity of HPV-negative oropharyngeal squamous cell carcinoma using miR-130b2021
- Author(s)
  Inoue Hitoshi、Hirasaki Masataka、Kogashiwa Yasunao、Kuba Kiyomi、Ebihara Yasuhiro、Nakahira Mitsuhiko、Sakai Akihiro、Okuda Akihiko、Sugasawa Masashi
- Journal Title
  
  Acta Oto-Laryngologica
  
  Volume: 1 Issue: 6 Pages: 1-6
- DOI
  10.1080/00016489.2021.1897160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16860, KAKENHI-PROJECT-19H03426, KAKENHI-PROJECT-21K06825
[Journal Article] Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation2020
- Author(s)
  Liu Chao、Sadat Sayed H、Ebisumoto Koji、Sakai Akihiro、Panuganti Bharat A、Ren Shuling、Goto Yusuke、Haft Sunny、Fukusumi Takahito、Ando Mizuo、Saito Yuki、Guo Theresa、Tamayo Pablo、Yeerna Huwate、Kim William、Hubbard Jacqueline、Sharabi Andrew B、Gutkind J. Silvio、Califano Joseph A.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 26 Issue: 11 Pages: 2693
- DOI
  10.1158/1078-0432.ccr-18-3301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09316, KAKENHI-PROJECT-18K16860
[Journal Article] Reciprocal activation of HEY1 and NOTCH4 under SOX2 control promotes EMT in head and neck squamous cell carcinoma2020
- Author(s)
  Fukusumi Takahito、Guo Theresa、Ren Shuling、Haft Sunny、Liu Chao、Sakai Akihiro、Ando Mizuo、Saito Yuki、Sadat Sayed、Califano Joseph
- Journal Title
  
  International Journal of Oncology
  
  Volume: 58 Issue: 2 Pages: 226-237
- DOI
  10.3892/ijo.2020.5156
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09316, KAKENHI-PROJECT-19K09909, KAKENHI-PROJECT-18K16860
[Journal Article] The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma.2020
- Author(s)
  Hirai H、Tada Y、Nakaguro M、Kawakita D、Sato Y、Shimura T、Tsukahara K、Kano S、Ozawa H、Okami K、Sato Y、Fushimi C、Shimizu A、Okamoto I、Takase S、Okada T、Sato H、Imanishi Y、Otsuka K、Watanabe Y、Sakai A、Ebisumoto K、Togashi T、Ueki Y、Ota H、Saigusa N、Takahashi H、Ando M、Urano M、Hanazawa T、Nagao T
- Journal Title
  
  Virchows Arch
  
  Volume: X Issue: 2 Pages: 291-299
- DOI
  10.1007/s00428-020-02777-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09386, KAKENHI-PROJECT-17K08753, KAKENHI-PROJECT-18K09340, KAKENHI-PROJECT-20K09763, KAKENHI-PROJECT-20K10508, KAKENHI-PROJECT-18K16860, KAKENHI-PROJECT-20K07417
[Journal Article] Aberrant expression of CPSF1 promotes head and neck squamous cell carcinoma via regulating alternative splicing2020
- Author(s)
  Sakai Akihiro、Ando Mizuo、Fukusumi Takahito、Ren Shuling、Liu Chao、Qualliotine Jesse、Haft Sunny、Sadat Sayed、Saito Yuki、Guo Theresa W.、Xu Guorong、Sasik Roman、Fisch Kathleen M.、Gutkind J. Silvio、Fertig Elana J.、Molinolo Alfredo A.、Califano Joseph A.
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 5 Pages: e0233380-e0233380
- DOI
  10.1371/journal.pone.0233380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09316, KAKENHI-PROJECT-18K16860
[Journal Article] Prognostic Implication of Histopathologic Indicators in Salivary Duct Carcinoma2020
- Author(s)
  Nakaguro Masato、Sato Yukiko、Tada Yuichiro、Kawakita Daisuke、Nagao Toshitaka et al.
- Journal Title
  
  The American Journal of Surgical Pathology
  
  Volume: 44 Issue: 4 Pages: 526-535
- DOI
  10.1097/pas.0000000000001413
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08753, KAKENHI-PROJECT-18K16860, KAKENHI-PROJECT-19K16568, KAKENHI-PROJECT-17K08705, KAKENHI-PROJECT-20K09763, KAKENHI-PROJECT-20K10508, KAKENHI-PROJECT-18K09386, KAKENHI-PROJECT-20K07417
[Journal Article] HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers2020
- Author(s)
  Ren Shuling、Gaykalova Daria A.、Guo Theresa、Favorov Alexander V.、Fertig Elana J.、Tamayo Pablo、Callejas-Valera Juan Luis、Allevato Mike、Gilardi Mara、Santos Jessica、Fukusumi Takahito、Sakai Akihiro、et al.
- Journal Title
  
  Oncogene
  
  Volume: 39 Issue: 40 Pages: 6327-6339
- DOI
  10.1038/s41388-020-01431-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16860
[Journal Article] Rational genomic optimization of DNA detection for human papillomavirus type 16 in head and neck squamous cell carcinoma2020
- Author(s)
  Saito Y, Favorov AV, Forman M, Ren S, Sakai A, Fukusumi T, Liu C, Sadat S, Ando M, Xu G, Khan Z, Pang J, Valsamakis A, Fisch KM, Califano JA.
- Journal Title
  
  Head & Neck
  
  Volume: 42 Issue: 4 Pages: 688-697
- DOI
  10.1002/hed.26041
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0334, KAKENHI-PROJECT-18K09316, KAKENHI-PROJECT-18K16860
[Journal Article] Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus?positive oropharyngeal squamous cell carcinoma2019
- Author(s)
  Haft Sunny、Ren Shuling、Xu Guorong、Mark Adam、Fisch Kathleen、Guo Theresa W.、Khan Zubair、Pang John、Ando Mizuo、Liu Chao、Sakai Akihiro、Fukusumi Takahito、Califano Joseph A.
- Journal Title
  
  Cancer
  
  Volume: 125 Issue: 14 Pages: 2423-2434
- DOI
  10.1002/cncr.32068
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16860, KAKENHI-PROJECT-15KK0334
[Journal Article] Evaluation of Nasal Airflow and Resistance: Computational Modeling for Experimental Measurements.2019
- Author(s)
  Kaneda S, Iida M, Yamamoto H, Sekine M, Ebisumoto K, Sakai A, Takakura Y.
- Journal Title
  
  Tokai J Exp Clin Med
  
  Volume: 44 Pages: 59-67
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16860
[Journal Article] Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers2019
- Author(s)
  Ando Mizuo、Saito Yuki、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 2188-2188
- DOI
  10.1038/s41467-019-09937-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09316, KAKENHI-PROJECT-18K16860, KAKENHI-PROJECT-15KK0334
[Journal Article] A novel splice variant of LOXL2 promotes progression of human papillomavirus?negative head and neck squamous cell carcinoma2019
- Author(s)
  Liu Chao、Guo Theresa、Sakai Akihiro、Ren Shuling、Fukusumi Takahito、Ando Mizuo、Sadat Sayed、Saito Yuki、Califano Joseph A.
- Journal Title
  
  Cancer
  
  Volume: 126 Issue: 4 Pages: 737-748
- DOI
  10.1002/cncr.32610
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09316, KAKENHI-PROJECT-18K16860, KAKENHI-PROJECT-15KK0334
[Journal Article] The high expression of FOXA1 is correlated with a favourable prognosis in salivary duct carcinomas: a study of 142 cases2018
- Author(s)
  Urano Makoto、Hirai Hideaki、Tada Yuichiro、Otsuka Kuninori、Watanabe Yoshihiro、Sakai Akihiro、Ebisumoto Koji、Togashi Takafumi、Ueki Yushi、Ota Hisayuki、Sato Yukiko、Saigusa Natsuki、Nakaguro Masato、Hanazawa Toyoyuki、Nagao Toshitaka
- Journal Title
  
  Histopathology
  
  Volume: 73 Issue: 6 Pages: 943-952
- DOI
  10.1111/his.13706
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08705, KAKENHI-PROJECT-17K08753, KAKENHI-PROJECT-18K09386, KAKENHI-PROJECT-17K18006, KAKENHI-PROJECT-18K16860, KAKENHI-PROJECT-16K19072
[Journal Article] Chronological Progression of an Enlarged Styloid Process: A Case Report of Eagle Syndrome2018
- Author(s)
  Maki Daisuke、Okami Kenji、Ebisumoto Koji、Sakai Akihiro
- Journal Title
  
  Case Reports in Otolaryngology
  
  Volume: 2018 Pages: 1-4
- DOI
  10.1155/2018/9207264
- Data Source
  KAKENHI-PROJECT-18K16860
[Journal Article] Discovery and development of differentially methylated regions in human papillomavirus-related oropharyngeal squamous cell carcinoma2018
- Author(s)
  Ren Shuling、Gaykalova Daria、Wang Jennifer、Guo Theresa、Danilova Ludmila、Favorov Alexander、Fertig Elana、Bishop Justin、Khan Zubair、Flam Emily、Wysocki Piotr T.、DeJong Peter、Ando Mizuo、Liu Chao、Sakai Akihiro、Fukusumi Takahito、Haft Sunny、Sadat Sayed、Califano Joseph A.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 143 Issue: 10 Pages: 2425-2436
- DOI
  10.1002/ijc.31778
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16860, KAKENHI-PROJECT-15KK0334
[Journal Article] How to improve the endoscopic view of the hypopharynx: Validation of our novel modified Killian's Method to expose the hypopharynx in 20 subjects2018
- Author(s)
  Sakai A.、Okami K.、Ebisumoto K.、Yamamoto H.、Saito K.、Maki D.、Furuya H.、Iida M.
- Journal Title
  
  Clinical Otolaryngology
  
  Volume: 43 Issue: 5 Pages: 1407-1410
- DOI
  10.1111/coa.13172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16860
[Journal Article] Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant2018
- Author(s)
  Liu Chao、Guo Theresa、Xu Guorong、Sakai Akihiro、Ren Shuling、Fukusumi Takahito、Ando Mizuo、Sadat Sayed、Saito Yuki、Khan Zubair、Fisch Kathleen M.、Califano Joseph
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 20 Issue: 20 Pages: 5123-5132
- DOI
  10.1158/1078-0432.ccr-18-0752
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09316, KAKENHI-PROJECT-18K16860, KAKENHI-PROJECT-15KK0334, KAKENHI-PROJECT-16K20230
[Presentation] Prognostic Value of Inflammatory and Nutritional Biomarkers of Immune Checkpoint Inhibitors for Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck2023
- Author(s)
  Akihiro Sakai
- Organizer
  The 8th conference of ASHNO 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16935
[Presentation] 上手な咽喉頭内視鏡所見の撮り方2023
- Author(s)
  酒井昭博
- Organizer
  第47回日本頭頸部癌学会・学術講演会
- Data Source
  KAKENHI-PROJECT-22K16935
[Presentation] Prognostic factors for nivolumab in recurrent metastatic head and neck cancer2023
- Author(s)
  Hiroaki Iijima, Akihiro Sakai
- Organizer
  The 8th conference of ASHNO 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16935
[Presentation] 頭頸部癌における選択的スプライシングを介した発癌機構の解明2019
- Author(s)
  酒井昭博
- Organizer
  第42回　頭頚部癌学会
- Data Source
  KAKENHI-PROJECT-18K16860

1. 長尾俊孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 多田雄一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 平井秀明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 齊藤祐毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
5. 伏見千宙

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 佐藤由紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 安藤瑞生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakai Akihiro 酒井 昭博

Akihiro Sakai 酒井 昭博

Research Projects

Research Products

Co-Researchers

頭頸部癌におけるスプライシング関連遺伝子CPSF1遺伝子異常による発癌機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring the mechanisms of carcinogenesis through the aberrant alternative splicing in head and neck cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Computed Tomography to Diagnose Paranasal Sinus Chemical Burns and Tissue Damage: A Case Report2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predicting the radiosensitivity of HPV-negative oropharyngeal squamous cell carcinoma using miR-130b2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reciprocal activation of HEY1 and NOTCH4 under SOX2 control promotes EMT in head and neck squamous cell carcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aberrant expression of CPSF1 promotes head and neck squamous cell carcinoma via regulating alternative splicing2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic Implication of Histopathologic Indicators in Salivary Duct Carcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rational genomic optimization of DNA detection for human papillomavirus type 16 in head and neck squamous cell carcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus?positive oropharyngeal squamous cell carcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of Nasal Airflow and Resistance: Computational Modeling for Experimental Measurements.2019

Author(s)

Journal Title

Data Source

[Journal Article] Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel splice variant of LOXL2 promotes progression of human papillomavirus?negative head and neck squamous cell carcinoma2019

Author(s)

Journal Title

DOI

Sakai Akihiro 酒井昭博

Akihiro Sakai 酒井昭博