YAGI Ryoji 八木良二

… Alternative Names

八木良二ヤギリヨウジ

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Researcher Number	20392152
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2020: 千葉大学, 大学院医学研究院, 特任准教授 2013 – 2015: 千葉大学, 医学(系)研究科(研究院), 特任准教授 2006: 理研, 研究員 2005: 独立行政法人理化学研究所, シグナル・ネットワーク研究チーム, 研究員
Review Section/Research Field	Principal Investigator Immunology / Basic Section 49070:Immunology-related / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator 転写因子 / IL-9 / サイトカイン / ヘルパーT細胞 / Th9 / T細胞 / 炎症 / Th9細胞 / アレルギー / Th2細胞 … More / transcription factor / CD4T cells / cytokine / 免疫 / 遷延化 / 遺伝子発現制御 / アレルギー・ぜんそく / 免疫学 / 遺伝子発現 / cis-element / NKT細胞 / 好塩基球 / マスト細胞 / IL-4 … More Except Principal Investigator Notch / IL-4 / 自己免疫 / 抗体 / FACS / SEREX法 / SEREX / フローサイトメトリー / 自己抗体 / 神経免疫疾患 / 視神経脊髄炎 / Transcriptional factor / Memory T cell / Chromatin / IL-2 / 転写因子 / 記憶型T細胞 / クロマチン Less

Th9細胞の分化メカニズムの解明と癌治療への展開Principal Investigator
- Principal Investigator
  
  八木良二
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Chiba University
Comprehensive search of autoantibies in neuroimmunological disorders using a novel hybrid SEREX-FACS method
- Principal Investigator
  
  Masahiro Mori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Chiba University
Molecular mechanisms regulating Th9 cell differentiationPrincipal Investigator
- Principal Investigator
  
  YAGI Ryoji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Molecular mechanisms of Th9 cell-mediated chronic inflammationPrincipal Investigator
- Principal Investigator
  
  YAGI Ryoji
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Chiba University
マスト細胞、好塩基球およびNKT細胞におけるIL-4遺伝子の発現制御機構の解析Principal Investigator
- Principal Investigator
  
  八木良二
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The Institute of Physical and Chemical Research
Development of therapeutic strategy for allergic diseases based on the genome information
- Principal Investigator
  
  KUBO Masato
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Laboratory for Signal Network, Research Center for Allergy and Immunology (RCAI), RIKEN Yokohama Institute

All 2019 2018 2017 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] A new therapeutic target: the CD69-Myl9 system in immune responses2019
- Author(s)
  Kimura Motoko Y.、Koyama-Nasu Ryo、Yagi Ryoji、Nakayama Toshinori
- Journal Title
  
  Seminars in Immunopathology
  
  Volume: - Issue: 3 Pages: 349-358
- DOI
  10.1007/s00281-019-00734-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07165, KAKENHI-PUBLICLY-17H05787, KAKENHI-PROJECT-18K07257, KAKENHI-PUBLICLY-19H04800, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-18K19466
[Journal Article] BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses2019
- Author(s)
  Dey Anup、Yang Wenjing、Gegonne Anne、Nishiyama Akira、Pan Richard、Yagi Ryoji、Grinberg Alex、Finkelman Fred D、Pfeifer Karl、Zhu Jinfang、Singer Dinah、Zhu Jun、Ozato Keiko
- Journal Title
  
  The EMBO Journal
  
  Volume: 38 Issue: 7
- DOI
  10.15252/embj.2018100293
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07165
[Journal Article] CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation2018
- Author(s)
  Kimura Motoko Y.、Igi Akemi、Hayashizaki Koji、Mita Yukiyoshi、Shinzawa Miho、Kadakia Tejas、Endo Yukihiro、Ogawa Satomi、Yagi Ryoji、Motohashi Shinichiro、Singer Alfred、Nakayama Toshinori
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 3749-3749
- DOI
  10.1038/s41467-018-06283-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07165, KAKENHI-PROJECT-18K19466, KAKENHI-PUBLICLY-17H05787, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-18H02892
[Journal Article] Bcl11b, a novel GATA3-interacting protein, suppresses Th1 while limiting Th2 cell differentiation2018
- Author(s)
  Fang Difeng、Cui Kairong、Hu Gangqing、Gurram Rama Krishna、Zhong Chao、Oler Andrew J.、Yagi Ryoji、Zhao Ming、Sharma Suveena、Liu Pentao、Sun Bing、Zhao Keji、Zhu Jinfang
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: - Issue: 5 Pages: 1449-1462
- DOI
  10.1084/jem.20171127
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08523, KAKENHI-PROJECT-18K07165
[Journal Article] Histone demethylases UTX and JMJD3 are required for NKT cell development in mice2017
- Author(s)
  Northrup Daniel、Yagi Ryoji、Cui Kairong、Proctor William R.、Wang Chaochen、Placek Katarzyna、Pohl Lance R.、Wang Rongfu、Ge Kai、Zhu Jinfang、Zhao Keji
- Journal Title
  
  Cell & Bioscience
  
  Volume: 7 Issue: 1
- DOI
  10.1186/s13578-017-0152-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08523
[Journal Article] IL-7Rα Expression Regulates Murine Dendritic Cell Sensitivity to Thymic Stromal Lymphopoietin2017
- Author(s)
  Kummola Laura、Ortutay Zsuzsanna、Chen Xi、Caucheteux Stephane、Hamalainen Sanna、Aittomaki Saara、Yagi Ryoji、Zhu Jinfang、Pesu Marko、Paul William E.、Junttila Ilkka S.
- Journal Title
  
  Journal of Immunology
  
  Volume: 198 Issue: 10 Pages: 3909-3918
- DOI
  10.4049/jimmunol.1600753
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08523
[Journal Article] Th2細胞における転写因子GATA3の役割2015
- Author(s)
  八木良二
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 第64巻第1号 Pages: 103-106
- NAID
  40020540548
- Data Source
  KAKENHI-PROJECT-15K08523
[Journal Article] Pathogenic memory type Th2 cells in allergic inflammation2014
- Author(s)
  Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., and Nakayama, T.
- Journal Title
  
  Trends Immunol
  
  Volume: 35(2) Issue: 2 Pages: 69-78
- DOI
  10.1016/j.it.2013.11.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790461, KAKENHI-PROJECT-25893032, KAKENHI-PROJECT-25893033
[Journal Article] The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells.2014
- Author(s)
  Yagi, R., Zhong, C., Northrup, D. L., Yu, F., Bouladoux, N., Spencer, S., Hu, G., Barron, L., Sharma, S., Nakayama, T., Belkaid, Y., Zhao, K., and Zhu, J.
- Journal Title
  
  Immunity
  
  Volume: 40 Issue: 3 Pages: 378-388
- DOI
  10.1016/j.immuni.2014.01.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893033
[Journal Article] Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.2013
- Author(s)
  Hosokawa H, Tanaka T, Kato M, Tohyama H, Hanazawa A, Tamaki Y, Hirahara K, Sakikawa I, Morita A, Nagira M, Suzuki Y, Nakayama T.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 110(46) Issue: 46 Pages: 18626-18631
- DOI
  10.1073/pnas.1311100110
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24116506, KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-24390239, KAKENHI-PROJECT-24592083, KAKENHI-PROJECT-25670438, KAKENHI-PROJECT-25860352, KAKENHI-PROJECT-25893032, KAKENHI-PROJECT-25893033
[Presentation] Molecular mechanisum for IFNg-mediated inhibition of Th2 cell proliferation2019
- Author(s)
  八木良二、Murshed Sarkar、木村元子、中山俊憲
- Organizer
  3rd Annual CU-UCSD cMAV Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07165
[Presentation] Roles of Th2 cell-related transcription factors, GATA3, STAT5 and Runx3, in Th9 differentiation2018
- Author(s)
  八木良二、中山俊憲
- Organizer
  第83回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07165
[Presentation] Th9細胞分化を制御する遺伝子の同定2018
- Author(s)
  八木良二
- Organizer
  第8回オルソオルガノジェネシス検討会
- Data Source
  KAKENHI-PROJECT-18K07165
[Presentation] Molecular mechanisum for IFNg-mediated inhibition of Th2 cell proliferation2018
- Author(s)
  八木良二、Murshed Sarkar、木村元子、中山俊憲
- Organizer
  第47回日本免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07165
[Presentation] Role of Th2-associated transcription factors in Th9 cell differentiation.2017
- Author(s)
  Yagi, R., Zhu, J., and Nakayama, T.
- Organizer
  7th International Workshop of Kyoto T Cell Conference
- Place of Presentation
  京都大学医学部・芝蘭会館（京都府京都市）
- Year and Date
  2017-03-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08523
[Presentation] リンパ組織形成のメカニズム2016
- Author(s)
  八木良二
- Organizer
  千葉大学リンパ浮腫研究シンポジウム
- Place of Presentation
  千葉大学医学部附属病院大講堂（ガーネットホール）（千葉県千葉市）
- Year and Date
  2016-03-05
- Data Source
  KAKENHI-PROJECT-15K08523
[Presentation] Role of a novel immune signaling molecule in Th2-type response.2016
- Author(s)
  Sarkar, H. M., Yagi, R., Nakajima, T., Nakayama, T., and Zhu, J.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄コンベンションセンター(沖縄県宜野湾市)
- Year and Date
  2016-12-07
- Data Source
  KAKENHI-PROJECT-15K08523
[Presentation] Th9細胞の役割と分化メカニズム2015
- Author(s)
  八木良二
- Organizer
  第151回日本獣医学会学術集会　微生物学分科会（免疫）シンポジウム
- Place of Presentation
  北里大学獣医学部（青森県十和田市）
- Year and Date
  2015-09-07
- Invited
- Data Source
  KAKENHI-PROJECT-15K08523
[Presentation] Role of the transcription factor GATA3 in helper T cell and innate lymphoid cell development2015
- Author(s)
  Yagi, R., Nakayama, T., and Zhu, J.
- Organizer
  Immunology 2015, The American Association of Immunologists, AAI Annual Meeting
- Place of Presentation
  New Orleans (USA)
- Year and Date
  2015-05-09
- Invited
- Data Source
  KAKENHI-PROJECT-25893033
[Presentation] Roles of IL-2 on Th9 cell differentiation2015
- Author(s)
  Sarkar, H. M., Yagi, R., Nakajima, T., Kimura, M., Nakayama, T., and Zhu, J.
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K08523
[Presentation] Role of the transcription factor GATA3 in helper T cell and innate lymphoid cell development2015
- Author(s)
  Ryoji Yagi
- Organizer
  Immunology 2015 AAI Annual Meeting
- Place of Presentation
  New Orleans (U.S.A)
- Year and Date
  2015-05-08
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08523
[Presentation] Molecular basis for acquisition of helper function during thymocyte development2015
- Author(s)
  Motoko Y. Kimura, Miho Shinzawa, Ruth Etzensperger, Ryoji Yagi, Koji Hayashizaki, Akemi Igi, Toshinori Nakayama and Alfred Singer
- Organizer
  Venice Thymus Meeting 2015
- Place of Presentation
  Venice (Italy)
- Year and Date
  2015-04-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08523
[Presentation] IL-9 production is a transient feature of differentiating Th2 cells in response to TGFβ.2014
- Author(s)
  Yagi, R., Sarkar, H. M., Soh, T., Nakayama, T., and Zhu, J.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-25893033
[Presentation] Role of the transcription factor GATA3 in helper T cell and innate lymphoid cell development.2014
- Author(s)
  Yagi, R.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-12-11
- Invited
- Data Source
  KAKENHI-PROJECT-25893033
[Presentation] Roles of Th2 differentiation-related transcription factors, GATA3, STAT5 and Runx3 in Th9 differentiation2013
- Author(s)
  八木良二
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ（千葉市）
- Data Source
  KAKENHI-PROJECT-25893033

1. KUBO Masato (40277281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Masahiro Mori (70345023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 鵜沢顕之 (10533317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 日和佐隆樹 (30260251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 星野忠次 (90257220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Sarkar Murshed

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 田中知明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 遠藤裕介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAGI Ryoji 八木 良二

八木 良二 ヤギ リヨウジ

Research Projects

Research Products

Co-Researchers

Th9細胞の分化メカニズムの解明と癌治療への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive search of autoantibies in neuroimmunological disorders using a novel hybrid SEREX-FACS method

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms regulating Th9 cell differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of Th9 cell-mediated chronic inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マスト細胞、好塩基球およびNKT細胞におけるIL-4遺伝子の発現制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of therapeutic strategy for allergic diseases based on the genome information

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A new therapeutic target: the CD69-Myl9 system in immune responses2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bcl11b, a novel GATA3-interacting protein, suppresses Th1 while limiting Th2 cell differentiation2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histone demethylases UTX and JMJD3 are required for NKT cell development in mice2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-7Rα Expression Regulates Murine Dendritic Cell Sensitivity to Thymic Stromal Lymphopoietin2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Th2細胞における転写因子GATA3の役割2015

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Pathogenic memory type Th2 cells in allergic inflammation2014

Author(s)

Journal Title

DOI

YAGI Ryoji 八木良二

八木良二ヤギリヨウジ