Nakashima kazue 中島一恵 (久岡一恵)

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HISAOKA-NAKASHIMA KAZUE 中島一恵

久岡一恵

中島一恵(久岡一恵) ナカシマカズエ

NAKASHIMA Kazue 中島一恵

HISAOKA Kazue 久岡一恵

久岡一恵ヒサオカカズエ

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Researcher Number	20393431
Other IDs
Affiliation (Current)	2025: 広島大学, 医系科学研究科(薬), 助教 2025: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 研究員(移行)
Affiliation (based on the past Project Information) *help	2018 – 2023: 広島大学, 医系科学研究科(薬), 助教 2017 – 2018: 広島大学, 医歯薬保健学研究科(薬), 助教 2013 – 2016: 広島大学, 医歯薬保健学研究院(薬), 助教 2015: 広島大学, 医歯薬保健学研究院, 助教 2012: 広島大学, 医歯薬保健学研究院, 助教 … More 2012: 広島大学, 大学院・医歯薬保健学研究院, 助教 2011: 広島大学, 医歯(薬)学総合研究科, 助教 2010: 広島大学, 薬学部, 助教 2008: 呉医療センター, 臨床研究部, 研究員 Less
Review Section/Research Field	Principal Investigator Pharmacology in pharmacy / Basic Section 47040:Pharmacology-related / Basic Section 48030:Pharmacology-related / General pharmacology Except Principal Investigator General pharmacology / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 47040:Pharmacology-related / Psychiatric science
Keywords	Principal Investigator 抗うつ薬 / 神経障害性疼痛 / ミクログリア / 薬理学 / アストロサイト / 神経栄養因子 / グリア / 慢性疼痛 / マトリックスメタロプロテアーゼ / うつ病 / グリア細胞 / 薬理作用 / 精神薬理学 … More Except Principal Investigator … More ミクログリア / アストロサイト / グリア細胞 / 核内受容体 / 鎮痛薬 / 慢性疼痛 / 脊髄アストロサイト / 神経障害性疼痛 / 精神神経疾患 / 認知機能障害 / 細胞老化 / ROR / 炎症性サイトカイン / マクロファージ / RORγ / 創薬 / SR9009 / 脊髄後角 / サイトカイン / REV-ERB / connexin36 / グルタミン酸 / プロテアソーム / ユビキチン / グルタミン酸トランスポーター / TNF / GSK-3β / cyclooxygenase-2 / interleukin-6 / connexin43 / プロテオミクス / 繊維芽細胞成長因子受容体 / アフィニティクロマトグラフィ / 神経栄養因子 / グリア / 抗うつ薬 / 精神薬理学 Less

海馬ミクログリアサブセットに着目した神経障害性疼痛の病態解明と新規治療法への応用Principal Investigator
- Principal Investigator
  
  中島一恵 (久岡一恵)
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Hiroshima University
慢性疼痛における核内受容体RORsの機能解析と新規治療戦略への応用
- Principal Investigator
  
  森岡徳光
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Hiroshima University
ミクログリアの細胞老化現象に着目した認知機能障害の発症・増悪機構の解明と応用
- Principal Investigator
  
  中村庸輝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Hiroshima University
The role of anterior cingulate cortical microglia in pathophysiology of neuropathic pain and novel drug targetsPrincipal Investigator
- Principal Investigator
  
  Hisaoka-Nakashima Kazue
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Hiroshima University
Role of nuclear receptor REV-ERB in chronic pain and their potential as therapeutic targets for analgesics
- Principal Investigator
  
  Morioka Norimitsu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hiroshima University
The role of matrix metalloproteinase in the antidepressant-induced glial cell line-derived neurotrophic factor expression in astrocytesPrincipal Investigator
- Principal Investigator
  
  Nakashima Kazue
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Hiroshima University
Involvement of spinal gap junction in induction and maintenance of chronic pain
- Principal Investigator
  
  Morioka Norimitsu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hiroshima University
The role of Fibroblast growth factor (FGF) signaling on the novel pharmacological action of antidepressants.Principal Investigator
- Principal Investigator
  
  HISAOKA-NAKASHIMA KAZUE
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Hiroshima University
The effect of antidepressant on Fibroblast growth factor (FGF) receptor, as a novel therapeutic target for major depression.Principal Investigator
- Principal Investigator
  
  NAKASHIMA Kazue (HISAOKA Kazue)
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Hiroshima University
Identification of novel targets related to induce expression of neurotrophic factors at antidepressant in glia
- Principal Investigator
  
  TAKEBAYASHI Minoru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  国立病院機構呉医療センター精神科
   Department of Clinical Research, National Hospital Organization Kure Medical Center

[Book] Recent Developments on Depression Research. (Shirayama Y, Chaki S (eds))2009
- Author(s)
  Takebayashi M, Hisaoka K, Tsuchioka M
- Publisher
  Glial dysfunction in mood disorders : the role of GDNF.
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Mitochondrial dysfunction and type I interferon signaling induce anxiodepressive-like behaviors in mice with neuropathic pain2023
- Author(s)
  Yoshimoto Natsuki、Nakamura Yoki、Hisaoka-Nakashima Kazue、Morioka Norimitsu
- Journal Title
  
  Experimental Neurology
  
  Volume: 367 Pages: 114470-114470
- DOI
  10.1016/j.expneurol.2023.114470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06163
[Journal Article] Inhibition of nuclear receptor RORγ ameliorates mechanical hypersensitivity through the suppression of spinal microglial activation.2023
- Author(s)
  Morioka N, Tsuruta M, Masuda N, Yamano K, Nakano M, Kochi T, Nakamura Y, Hisaoka-Nakashima K
- Journal Title
  
  Neuroscience
  
  Volume: 526 Pages: 223-236
- DOI
  10.1016/j.neuroscience.2023.07.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06628
[Journal Article] High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain2022
- Author(s)
  Kazue Hisaoka-Nakashima, Kazuto Ohata, Natsuki Yoshimoto, Shintarou Tokuda, Nanako Yoshii, Yoki Nakamura, Dengli Wang, Keyue Liu, Hidenori Wake, Takayuki Yoshida, Yukio Ago, Kouichi Hashimoto, Masahiro Nishibori, Norimitsu Morioka
- Journal Title
  
  Exp Neurol .
  
  Volume: 355 Pages: 114146-114146
- DOI
  10.1016/j.expneurol.2022.114146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17930, KAKENHI-PROJECT-20K07291
[Journal Article] Anti-interleukin-6 receptor antibody improves allodynia and cognitive impairment in mice with neuropathic pain following partial sciatic nerve ligation2022
- Author(s)
  Hisaoka-Nakashima Kazue、Moriwaki Kodai、Yoshimoto Natsuki、Yoshii Toshiki、Nakamura Yoki、Ago Yukio、Morioka Norimitsu
- Journal Title
  
  International Immunopharmacology
  
  Volume: 112 Pages: 109219-109219
- DOI
  10.1016/j.intimp.2022.109219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07291
[Journal Article] Perineural high-mobility group box 1 induces mechanical hypersensitivity through activation of spinal microglia: involvement of glutamate-NMDA receptor dependent mechanism in spinal dorsal horn.2021
- Author(s)
  Nakamura Y, Fukuta A, Miyashita K, Zhang FF, Wang D, Liu K, Wake H, Hisaoka-Nakashima K, Nishibori M, Morioka N
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 186 Pages: 114496-114496
- DOI
  10.1016/j.bcp.2021.114496
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07291, KAKENHI-PROJECT-19H03408, KAKENHI-PROJECT-20K18476
[Journal Article] Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice2019
- Author(s)
  Morioka Norimitsu、Kodama Keitaro、Tomori Mizuki、Yoshikawa Kanade、Saeki Munenori、Nakamura Yoki、Zhang Fang Fang、Hisaoka-Nakashima Kazue、Nakata Yoshihiro
- Journal Title
  
  Brain, Behavior, and Immunity
  
  Volume: 印刷中 Pages: 116-130
- DOI
  10.1016/j.bbi.2019.01.014
- NAID
  120006847077
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08596
[Journal Article] High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain2019
- Author(s)
  Hisaoka-Nakashima Kazue、Tomimura Yoshiaki、Yoshii Toshiki、Ohata Kazuto、Takada Naoki、Zhang Fang Fang、Nakamura Yoki、Liu Keyue、Wake Hidenori、Nishibori Masahiro、Nakata Yoshihiro、Morioka Norimitsu
- Journal Title
  
  Progress in Neuro-Psychopharmacology and Biological Psychiatry
  
  Volume: 92 Pages: 347-362
- DOI
  10.1016/j.pnpbp.2019.02.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21225, KAKENHI-PROJECT-16K08270
[Journal Article] Depression: A novel mechanism of antidepressant action with a focus on astrocytes2017
- Author(s)
  Takebayashi M, Hisaoka-Nakashima K, Okada Tsuchioka M, Shibasaki C, Abe H, and Kajitani N
- Journal Title
  
  Advances in Modern Medicine
  
  Volume: 1 Pages: 220-232
- Data Source
  KAKENHI-PROJECT-16K08270
[Journal Article] Pharmacological Activation Gi/o Protein Increases Glial Cell Line-Derived Neurotrophic Factor Production through Fibroblast Growth Factor Receptor and Extracellular Signal-Regulated Kinase Pathway in Primary Cultured Rat Cortical Astrocytes2017
- Author(s)
  Hisaoka-Nakashima K, Matsumoto C, Azuma H, Taki S, Takebayashi M, Nakata Y, Morioka N
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 10 Pages: 1759-1766
- DOI
  10.1248/bpb.b17-00383
- NAID
  130006110587
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08270
[Journal Article] The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells2016
- Author(s)
  Abe H, Hisaoka-Nakashima K, Kajitani N, Okada-Tsuchioka M, Yano R, Itagaki K, Shibasaki C, Morioka N, Nakata Y, Takebayashi M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 479 Issue: 4 Pages: 907-912
- DOI
  10.1016/j.bbrc.2016.09.070
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09819, KAKENHI-PROJECT-16K08270, KAKENHI-PROJECT-16K18883, KAKENHI-PROJECT-16K19796
[Journal Article] Identification of lysophosphatidic acid receptor 1 in astroglial cells as a target for glial cell line-derived neurotrophic factor expression induced by antidepressants.2016
- Author(s)
  Kajitani, N., Miyano, K., Okada-Tsuchioka, M., Abe, H., Itagaki, K., Hisaoka-Nakashima, K., Morioka, N., Uezono, Y., Takebayashi, M.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Issue: 53 Pages: 27364-27370
- DOI
  10.1074/jbc.m116.753871
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08686, KAKENHI-PROJECT-15K09819, KAKENHI-PROJECT-16K08270, KAKENHI-PROJECT-16K18883, KAKENHI-PROJECT-16K19796
[Journal Article] Stimulation of spinal dorsal horn β2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase.2016
- Author(s)
  Zhang F.F., Morioka N., Abe H., Fujii S., Miyauchi K., Nakamura Y., Hisaoka-Nakashima K., Nakata Y.
- Journal Title
  
  Neurochemistry International
  
  Volume: 101 Pages: 144-155
- DOI
  10.1016/j.neuint.2016.11.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460342
[Journal Article] Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression.2016
- Author(s)
  Zhang F.F., Morioka N., Kitamura T., Fujii S., Miyauchi K., Nakamura Y., Hisaoka-Nakashima K., Nakata Y.
- Journal Title
  
  Life Sciences
  
  Volume: 155 Pages: 116-122
- DOI
  10.1016/j.lfs.2016.05.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460342
[Journal Article] Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia.2016
- Author(s)
  Hisaoka-Nakashima K, Kajitani N, Kaneko M, Shigetou T, Kasai M, Matsumoto C, Yokoe T, Azuma H, Takebayashi M, Morioka N, Nakata Y
- Journal Title
  
  Brain Res
  
  Volume: 1634 Pages: 57-67
- DOI
  10.1016/j.brainres.2015.12.057
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25870461, KAKENHI-PROJECT-15K09819
[Journal Article] Proinflammatory cytokines downregulate connexin 43-gap junction in rat spinal astrocytes via ubiquitin-proteasome system.2015
- Author(s)
  Zhang F.F., Morioka N., Kitamura T., Hisaoka-Nakashima K., Nakata Y.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 464 Issue: 4 Pages: 1202-1208
- DOI
  10.1016/j.bbrc.2015.07.105
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460342
[Journal Article] Tricyclic antidepressant amitriptyline-induced glial cell line-derived neurotrophic factor production involves pertussis toxin-sensitive Gαi/o activation in astroglial cells.2015
- Author(s)
  Hisaoka-Nakashima K, Miyano K, Matsumoto C, Kajitani N, Abe H, Okada-Tsuchioka M, Yokoyama A, Uezono Y, Morioka N, Nakata Y, Takebayashi M.
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 22 Pages: 13678-13691
- DOI
  10.1074/jbc.m114.622415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590740, KAKENHI-PROJECT-25870461, KAKENHI-PROJECT-15K08686, KAKENHI-PROJECT-25860199
[Journal Article] Downregulation of connexin36 in mouse spinal dorsal horn neurons leads to mechanical allodynia2015
- Author(s)
  Nakamura Y, Morioka N, Zhang FF, Hisaoka-Nakashima K, Nakata Y
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 93 Issue: 4 Pages: 584-591
- DOI
  10.1002/jnr.23515
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460342
[Journal Article] Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves extracellular signal-regulated kinase-dependent early growth response 1 production in rat primary cultured astrocytes.2015
- Author(s)
  Kajitani N, Hisaoka-Nakashima K, Okada-Tsuchioka M, Hosoi M, Yokoe T, Morioka N, Nakata Y, Takebayashi M.
- Journal Title
  
  J Neurochem
  
  Volume: 135 Issue: 1 Pages: 27-37
- DOI
  10.1111/jnc.13247
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25870461
[Journal Article] Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice.2015
- Author(s)
  Morioka N., Zhang F.F., Nakamura Y., Kitamura T., Hisaoka-Nakashima K., Nakata Y.
- Journal Title
  
  Ｂｒａｉｎ，　Ｂｅｈａｖｉｏｒ，　ａｎｄ　Ｉｍｍｕｎｉｔｙ
  
  Volume: 49 Pages: 293-310
- DOI
  10.1016/j.bbi.2015.06.015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460342
[Journal Article] グリアと抗うつ薬2014
- Author(s)
  中島一恵、森岡徳光、仲田義啓、竹林実
- Journal Title
  
  分子精神医学
  
  Volume: 14 Pages: 9-14
- Data Source
  KAKENHI-PROJECT-25870461
[Journal Article] History of the G Protein–Coupled Receptor (GPCR) Assays From Traditional to a State-of-the-Art Biosensor Assay2014
- Author(s)
  Miyano K, Sudo Y, Yokoyama A, Hisaoka-Nakashima K, Morioka N, Takebayashi M, Shiraishi S, Nakata Y, Higami Y, Uezono Y.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 126 Issue: 4 Pages: 302-309
- DOI
  10.1254/jphs.14R13CP
- NAID
  130004704288
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590740, KAKENHI-PROJECT-25860200, KAKENHI-PROJECT-25870461, KAKENHI-PROJECT-25860199
[Journal Article] Tricyclic antidepressant amitriptyline indirectly increases the proliferation of adult dentate gyrus-derived neural precursors : an involvement of astrocytes.2013
- Author(s)
  Boku S, Hisaoka-Nahashima K, Nakagawa S, Kato A, Kaiitani N, Inoue T, Kusumi I, Takebayashi M
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 11 Pages: 116-124
- DOI
  10.1371/journal.pone.0079371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06852, KAKENHI-PROJECT-23591667, KAKENHI-PROJECT-23591686, KAKENHI-PROJECT-24591673, KAKENHI-PROJECT-25870461
[Journal Article] Antidepressant acts on astrocytes leading to an increase in the expression of neurotrophic/growth factors: differential regulation of FGF-2 by noradrenaline2012
- Author(s)
  Kajitani Naoto, Hisaoka-Nakashima Kazue, Morioka Norimitsu, Okada-Tsuchioka Mami, Kaneko Masahiro, Kasai Miho, Shibasaki Chiyo, Nakata Yoshihiro, Takebayashi Minoru.
- Journal Title
  
  PLoS One
  
  Volume: 7(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790297
[Journal Article] Riluzole-induced glial cell line-derived neurotrophic factor production is regulated through fibroblast growth factor receptor signaling in rat C6 glioma cells.2011
- Author(s)
  Tsuchioka M, Hisaoka K, Yano R, Shibasaki C, Kajiatani N, Takebayashi M.
- Journal Title
  
  Brain Res.
  
  Volume: 1384 Pages: 1-8
- DOI
  10.1016/j.brainres.2011.01.100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790297
[Journal Article] Asymmetric alternation of the hemodynamic response at the prefrontal cortex in patients with schizophrenia during electroconvulsive therapy: a near-infrared spectroscopy study.2011
- Author(s)
  Fujita Y, Takebayashi M, Hisaoka K, Tsuchioka M, Morinobu S, Yamawaki S.
- Journal Title
  
  Brain Res.
  
  Volume: 1410 Pages: 132-140
- DOI
  10.1016/j.brainres.2011.06.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790297
[Journal Article] Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor signaling in glial cells: involvement in glial cell line-derived neurotrophic factor production.2011
- Author(s)
  Hisaoka K, Tsuchioka M, Yano R, Maeda N, Kajitani N, Morioka N, Nakata Y, Takebayashi M.
- Journal Title
  
  J Biol Chem.
  
  Volume: 286(24) Issue: 24 Pages: 21118-21128
- DOI
  10.1074/jbc.m111.224683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790297
[Journal Article] Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor signaling in glial cells: involvement in glial cell line-derived neurotrophic factor production.2011
- Author(s)
  Hisaoka Kazue, Tsuchioka Mami, Yano Ryouya, Maeda Natsuko, Kajitani Naoto, Morioka Norimitsu, Nakata Yoshihiro, Takebayashi Minoru.
- Journal Title
  
  J Biol Chem
  
  Volume: 286(24) Pages: 21118-21128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790297
[Journal Article] Noradrenergic regulation of period1 expression in spinal astrocytes is involved in protein kinase A, c-Jun N-terminal kinase and extracellular signal-regulated kinase activation mediated by α1- and β2-adrenoceptors.2011
- Author(s)
  Sugimoto T, Morioka N, Sato K, Hisaoka K, Nakata Y.
- Journal Title
  
  Neuroscience.
  
  Volume: 185 Pages: 1-13
- DOI
  10.1016/j.neuroscience.2011.04.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790297
[Journal Article] Riluzole-induced glial cell line-derived neurotrophic factor production in regulated through fibroblast growth factor receptor signaling in rat C6 glioma cells.2011
- Author(s)
  Tsuchioka M, Hisaoka K, Yano R, Shibasaki C, Kajiatani N, Takebayashi M
- Journal Title
  
  Brain Research 1384
  
  Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Riluzole-induced glial cell line-derived neurotrophic factor production is regulated through fibroblast growth factor receptor signaling in rat C6 glioma cells2011
- Author(s)
  Tsuchioka Mami, Hisaoka Kazue, Yano Ryouya, Shibasaki Chiyo, Kajiatani Naoto, Takebayashi Minoru.
- Journal Title
  
  Brain Res
  
  Volume: 1384 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790297
[Journal Article] Plasma levels of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2) in patients with major depressive disorders.2010
- Author(s)
  Takebayashi M, Hashimoto R, Hisaoka K, Tsuchioka M, Kunugi H
- Journal Title
  
  Journal of Neural Transmission 117
  
  Pages: 1119-1122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Prior Neonatal Isolation Reduces Induction of NGF mRNA and Decreases GDNF mRNA in th Hippocampus of Juvenile and Adult Rodents Subjected to Immobilization Stress2008
- Author(s)
  Kawano K, Morinobu S, Sawada T, Tsuji S, Erabi K, Fuchikami M, Kozuru T, Yamawaki S, Hisaoka K, Takebayashi M
- Journal Title
  
  Synapse 62
  
  Pages: 259-267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Serotonin(5-HT)induces glial cell line-derived neurotrophic factor(GDNF)mRNA expression via the transactivation of fibroblast growth factor receptor 2(FGFR2)in rat C6 glioma cells2008
- Author(s)
  Tsuchioka M, Takebayashi M, Hisaoka K, Maeda N, Nakata Y.
- Journal Title
  
  Journal of Neurochemistry 106
  
  Pages: 244-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells.2008
- Author(s)
  Tsuchioka M, Takebayashi M, Hisaoka K, Maeda N, Nakata Y
- Journal Title
  
  Journal of Neurochemistry 106
  
  Pages: 244-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Antidepressants induce acute CREB phosphorylation and CRE-mediated gene expression in glial cells : a possible contribution to GDNF production.2008
- Author(s)
  Hisaoka K, Maeda N, Tsuchioka M, Takebayashi M
- Journal Title
  
  Brain Research 1196
  
  Pages: 53-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Antidepressants induce acute CREB phosphorylation and CRE-mediated gene expression in glial cells : a possible contribution to GDNF production2008
- Author(s)
  Hisaoka K, Maeda N, Tsuchioka M, Takebayashi M
- Journal Title
  
  Brain Research 1196
  
  Pages: 53-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT3
- Author(s)
  Boku Shuken, Nakagawa Shin, Takamura Naoki, Kato Akiko, Takebayashi Minoru, Hisaoka-Nakashima Kazue, Omiya Yuki, Inoue Takeshi, Kusumi Ichiro.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] ミクログリアの細胞老化に着目した老化マウスのうつ・不安様症状の解析2024
- Author(s)
  横畠未来、中村庸輝、池田圭佑、中島一恵、吾郷由希夫、佐藤綾美、石神昭人、森岡徳光
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 核内受容体 RORγ 阻害薬はミクログリア活性を抑制することで疼痛緩和効果を示す2024
- Author(s)
  升田菜緒、鶴田真帆、中村庸輝、中島一恵、森岡徳光
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06628
[Presentation] 神経障害性疼痛モデルマウスにおける不安・うつ様行動に対するHMGB1中和抗体経鼻投与の効果の検討2024
- Author(s)
  田上浩司、中島一恵、中村庸輝、西堀正洋、森岡徳光
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06163
[Presentation] ミクログリアへ及ぼす加齢の影響2023
- Author(s)
  中村庸輝、中島一恵、森岡徳光
- Organizer
  第46回日本基礎老化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] ミトコンドリア機能障害は mitochondrial DNA - cyclic GMP-AMP synthase を介してミクログリアの炎症応答を変化させる2023
- Author(s)
  中野雅凪矢、中村庸輝、岩本桃香、中島一恵、森岡徳光
- Organizer
  第143回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] パーキンソン病関連性疼痛に対する high mobility group box-1 中和抗体の鎮痛効果2023
- Author(s)
  中村庸輝、佐藤史爽、山野樹一、麻思萌、河内貴弘、中島一恵、王登莉、劉克約、和氣秀徳、西堀正洋、森岡徳光
- Organizer
  第53回日本神経精神薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] ミクログリアに対するロテノン処置は細胞質ミトコンドリア DNA 漏出を介して I 型インターフェロン産生を増強する2023
- Author(s)
  中村庸輝、中野雅凪矢、岩本桃香、中島一恵、森岡徳光
- Organizer
  フォーラム2023 - 衛生薬学・環境トキシコロジー -
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] Blockade of high mobility group box-1 function ameriolates mechanical hypersensitivity in a mouse model of Parkinson's disease2023
- Author(s)
  Nakamura Y, Sato F, Yamano K, Ma S, Kochi T, Hisaoka-Nakashima K, Wang D, Liu K, Wake H, Nishibori M, Morioka N
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 加齢に伴うミクログリア機能変容の解明を目指した新規研究手法の確立2023
- Author(s)
  中村庸輝、中島一恵、森岡徳光
- Organizer
  第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 神経障害性疼痛マウスの認知機能低下における脳ミクログリアの役割に関する検討2023
- Author(s)
  吉井　菜々子、中島　一恵、中村　庸輝、森岡　徳光
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会
- Data Source
  KAKENHI-PROJECT-23K06163
[Presentation] 神経障害性疼痛による認知機能障害発症メカニズムの解明 ‐clodronate liposomeを用いた検討‐2023
- Author(s)
  徳田　慎太朗、中島　一恵、中村　庸輝、森岡　徳光
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会
- Data Source
  KAKENHI-PROJECT-23K06163
[Presentation] Mitochondrial DNA- cyclic GMP-AMP synthase 経路がミクログリアの炎症応答に及ぼす影響2023
- Author(s)
  中野雅凪矢、中村庸輝、岩本桃香、森岡徳光、中島一恵
- Organizer
  第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] The emerging role of HMGB1 in the brain during chronic pain.2023
- Author(s)
  Nakamura Y, Nakashima K, Morioka N
- Organizer
  19th World Congress of Basic & Clinical Pharmacology 2023 (WCP2023)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] ミクログリアにおけるミトコンドリア機能障害は mitochondrial DNA-cyclic GMP-AMP synthase を介し interferonβ 産生を増強する2023
- Author(s)
  中野雅凪矢、中村庸輝、岩本桃香、中島一恵、森岡徳光
- Organizer
  次世代を担う若手のための創薬・医療薬理シンポジウム 2023
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 細胞質へ漏出したミトコンドリア DNA のミクログリアの炎症反応へ及ぼす影響2022
- Author(s)
  中村庸輝、中島一恵、森岡徳光
- Organizer
  第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会 (JPW2022)
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 神経障害性疼痛マウスにおける認知機能障害に対するHMGB1中和抗体の効果に関する検討2022
- Author(s)
  吉本夏輝、中島一恵、大畑一努、中村庸輝、王登莉、劉克約、和氣秀徳、吾郷由希夫、西堀正洋、森岡徳光
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] Cytosolic mitochondrial DNA enhances the IRF3 response in microglia with mitochondrial dysfunction2022
- Author(s)
  中村庸輝、中野雅凪矢、池田圭佑、岩本桃香、中島一恵、森岡徳光
- Organizer
  第45回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 老化様ミクログリアにおける炎症応答変化の解析2022
- Author(s)
  池田圭佑、中村庸輝、中野雅凪矢、中島一恵、森岡徳光
- Organizer
  第 1 回広島大学脳神経科学セミナー
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 難治性疼痛に対する創薬標的としての HMGB1 の可能性2022
- Author(s)
  中村庸輝、中島一恵、森岡徳光
- Organizer
  生体機能と創薬シンポジウム 2022
- Invited
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 老化様ミクログリア作製手法の確立と炎症応答変化の解析2022
- Author(s)
  中村庸輝, 池田圭佑, 中野雅凪矢, 中島一恵, 森岡徳光
- Organizer
  第38回創薬・薬理フォーラム岡山
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 慢性疼痛モデル：抗体製剤の経鼻投与による疼痛と付随する情動・認知機能異常に対する改善効果2022
- Author(s)
  森岡徳光、中村庸輝、中島一恵、西堀正洋
- Organizer
  第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 老化様ミクログリアの作製方法の確立と炎症応答変化の解析2022
- Author(s)
  池田圭佑、中村庸輝、中野雅凪矢、中島一恵、森岡徳光
- Organizer
  第142回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] ラット大脳皮質由来初代培養ミクログリアにおけるglucocorticoid誘導性 high-mobility group box-1放出メカニズムの検討2022
- Author(s)
  竹内佑香、中島一恵、中村庸輝、王登莉、劉克約、西堀正洋、森岡徳光
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 海馬のミトコンドリア機能障害は神経障害性疼痛マウスに不安・うつ行動を誘発する2022
- Author(s)
  吉本夏輝、中島一恵、中村庸輝、森岡徳光
- Organizer
  第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] ミクログリアのミトコンドリア機能障害と炎症応答変化2022
- Author(s)
  中村庸輝、中野雅凪矢、池田圭佑、中島一恵、森岡徳光
- Organizer
  第 1 回広島大学脳神経科学セミナー
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 神経障害性疼痛により生じる認知機能低下に対するHMGB1の関与2021
- Author(s)
  中島一恵, 大畑一努, 森脇航大, 吉本夏輝, 中村庸輝, 王登莉, 劉克約, 和氣秀徳, 西堀正洋, 森岡徳光
- Organizer
  第43回日本生物学的精神医学会第51回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 慢性疼痛によるストレスがもたらす情動・認知機能異常へのhigh mobility box-1とミクログリアの関与2021
- Author(s)
  森岡徳光, 中島一恵, 中村庸輝
- Organizer
  第43回日本生物学的精神医学会第51回日本神経精神薬理学会合同年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 神経障害性疼痛モデルマウスの脳におけるミトコンドリア由来DAMPsの発現変化に関する検討2021
- Author(s)
  吉本夏輝、中島一恵、中村庸輝、森岡徳光
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 神経障害性疼痛モデルマウスにおける海馬での神経可塑性変化に関する検討2021
- Author(s)
  吉本夏輝、中島一恵、中村庸輝、吾郷由紀夫、森岡徳光
- Organizer
  第60回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 神経障害性疼痛モデルマウスにおける脳内ミトコンドリア由来DAMPs発現変化とミトコンドリア機能障害に関する検討2021
- Author(s)
  吉本夏輝、中島一恵、中村庸輝、森岡徳光
- Organizer
  第139回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 神経障害性疼痛マウスの認知機能低下に対するHMGB1の役割に関する検討2020
- Author(s)
  大畑一努、中島一恵、森脇航大、吉本夏輝、中村庸輝、王登莉、劉克約、和氣秀徳、西堀正洋、森岡徳光
- Organizer
  第59回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] ミクログリアにおける核内受容体 REV-ERBs の炎症制御機構の解明2019
- Author(s)
  児玉景太郎, 鶴田真帆, 武村昌俊, 岩本桃香, 中村庸輝, 中島一恵, 森岡徳光
- Organizer
  第136回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17K08596
[Presentation] Effects of nuclear receptor reverb on proinflammatory responses in cultured microglia.2019
- Author(s)
  Kodama K, Yoshikawa K, Takemura M, Nakamura Y, Nakashima K, Morioka N
- Organizer
  Society for Neuroscience Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08596
[Presentation] ラット大脳皮質初代培養アストロサイトにおいてミルタザピンはGDNF 産生を増加する2018
- Author(s)
  高城　冴花、中島　一恵、渡辺　慎太郎、中村　庸輝、仲田　義啓、森岡　徳光
- Organizer
  第57回日本薬学会・日本病院薬剤師会・中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-16K08270
[Presentation] 脊髄アストロサイトにおける核内受容体REV-ERBsを介した炎症性疼痛緩和効果の検討2018
- Author(s)
  吉川　奏，児玉景太郎，中村庸輝，中島一恵，仲田義啓, 森岡徳光
- Organizer
  第57回日本薬学会・日本薬剤師会・日本病院薬剤師会・中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-17K08596
[Presentation] The analysis of anxiety- and depression-related behaviors in neuropathic pain of mice - possible involvement of brain inflammation2018
- Author(s)
  Kazue Hisaoka-Nakashima, Yoshiaki Tomimura, Toshiki Yoshii, Fang Fang Zhang, Yoki Nakamura, Keyue Liu, Masahiro Nishibori, Yoshihiro Nakata, Norimitsu Morioka
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08270
[Presentation] 神経障害性疼痛モデルマウスにおけるうつ様行動と脳ミクログリア機能解析2017
- Author(s)
  中島一恵、富村昌暉、吉井稔紀、張　芳芳、仲田義啓、森岡徳光
- Organizer
  第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-16K08270
[Presentation] Antidepressant amitriptyline activates matrix metalloproteinase in astroglial cells: involvement in glial cell line-derived neurotrophic factor expression.2016
- Author(s)
  H. ABE, K. HISAOKA-NAKASHIMA, N. KAJITANI, M. OKADA-TSUCHIOKA, K. ITAGAKI, C. SHIBASAKI, M. MORIOKA, Y. NAKATA, M. TAKEBAYASHI
- Organizer
  30th CINP WORLD CONGRESS OF NEUROPSYCHOPHARMACOLOGY
- Place of Presentation
  Seoul
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08270
[Presentation] A role of spinal astrocytic connexin43 in maintenance of neuropathic pain.2016
- Author(s)
  藤井志織, 森岡徳光, 張　芳芳, 中島一恵, 仲田義啓
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 脊髄アストロサイトにおけるconnexin43の発現低下はIL-6及びCOX-2の発現増加を介して痛みを誘発する2016
- Author(s)
  藤井志織, 張　芳芳, 中島一恵, 仲田義啓, 森岡徳光
- Organizer
  第130回日本薬理学会近畿部会
- Place of Presentation
  京都大学百周年時計台記念館
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 神経障害性疼痛発症時における脊髄アストロサイトConnexin43の新たな役割2016
- Author(s)
  藤井志織, 張　芳芳, 中島一恵, 仲田義啓, 森岡徳光
- Organizer
  第129回日本薬理学会近畿部会
- Place of Presentation
  広島県医師会館
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] ラット初代培養アストロサイトにおいてリゾフォスファチジン酸がトロンボスポンジン１発現に与える効果の検討2016
- Author(s)
  横江俊樹、中島一恵、東穂奈美、高城冴花、仲田義啓、森岡徳光
- Organizer
  第55回日本薬学会・日本薬剤師会・日本病院薬剤師会　中国四国支部学術大会
- Place of Presentation
  岡山
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-16K08270
[Presentation] Antidepressants activate matrix metalloproteinase (MMP) in astroglial cells: involvement in glial cell line-derived neurotrophic factor (GDNF) expression2015
- Author(s)
  H. ABE, K. HISAOKA-NAKASHIMA, N. KAJITANI, M. OKADA-TSUCHIOKA, K. ITAGAKI, M. MORIOKA, Y. NAKATA, M. TAKEBAYASHI
- Organizer
  45th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25870461
[Presentation] アミトリプチリンはアストロサイトにおいてGai/oを活性化しグリア細胞由来神経栄養因子（GDNF）を産生する2015
- Author(s)
  中島　一恵、宮野　加奈子、松本　千枝、梶谷　直人、安部　裕美、岡田　麻美、横山　明信、上園　保仁、森岡　徳光、竹林　実、仲田　義啓
- Organizer
  第127回日本薬理学会近畿部会
- Place of Presentation
  岐阜市
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PROJECT-25870461
[Presentation] The role of spinal astrocytic Cx43 in the maintenance of neuropathic pain2015
- Author(s)
  Zhang F., Morioka N., Nakamura Y., Fujii S., Hisaoka-Nakashima K., Nakata Y.
- Organizer
  45th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 脊髄アストロサイトConnexin43発現低下による神経障害性疼痛発症メカニズムの解析2015
- Author(s)
  藤井志織, 森岡徳光, 張　芳芳, 中島一恵, 仲田義啓
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2015
- Place of Presentation
  東京大学薬学部
- Year and Date
  2015-08-29
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] ラットアストログリア細胞において三環系抗うつ薬アミトリプチリンはMMP-9活性化を介してグリア細胞由来神経栄養因子（GDNF）mRNA発現を増加させる2015
- Author(s)
  安倍裕美、中島一恵、梶谷直人、岡田麻実、板垣圭、森岡徳光、仲田義啓、竹林実
- Organizer
  第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
- Place of Presentation
  東京
- Year and Date
  2015-09-24
- Data Source
  KAKENHI-PROJECT-25870461
[Presentation] ラット初代培養ミクログリアにおいて三環系抗うつ薬アミトリプチリンが脳由来神経栄養因子(BDNF)mRNA 発現に及ぼす効果の検討2014
- Author(s)
  重藤　貴大、中島　一恵、梶谷　直人、竹林　実、森岡　徳光、仲田　義啓
- Organizer
  第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  広島（広島国際会議場）
- Year and Date
  2014-11-08
- Data Source
  KAKENHI-PROJECT-25870461
[Presentation] 脊髄アストロサイトgap junction-Cx43発現低下に対するproteasome系の役割2014
- Author(s)
  張　芳芳、森岡徳光、北村智哉、藤井志織、中島一恵、仲田義啓
- Organizer
  第125回日本薬理学会近畿部会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 脊髄アストロサイトConnexin43の神経障害性疼痛発症への関与2014
- Author(s)
  北村智哉、森岡徳光、張　芳芳、藤井志織、中島一恵、仲田義啓
- Organizer
  第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  広島国際会議場
- Year and Date
  2014-11-08
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 脊髄アストロサイトConnexin43の神経障害性疼痛における機能解明2014
- Author(s)
  北村智哉、森岡徳光、張　芳芳、中島一恵、仲田義啓
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2014
- Place of Presentation
  近畿大学東大阪キャンパス
- Year and Date
  2014-08-30
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 神経障害性疼痛に対する脊髄後角におけるアストロサイトCx43の関与2014
- Author(s)
  張　芳芳、森岡徳光、北村智哉、藤井志織、中島一恵、仲田義啓
- Organizer
  第126回日本薬理学会近畿部会
- Place of Presentation
  和歌山県JAビル
- Year and Date
  2014-10-24
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 7)アミトリプチリンによるグリア細胞株由来神経栄養因子産生メカニズムの解明：マトリックスメタロプロテアーゼの関与2014
- Author(s)
  安部　裕美、中島　一恵、岡田　麻美、梶谷　直人、板垣　圭、森岡　徳光、竹林　実、仲田　義啓
- Organizer
  第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  広島（広島国際会議場）
- Year and Date
  2014-11-08
- Data Source
  KAKENHI-PROJECT-25870461
[Presentation] ラット初代培養ミクログリアにおける脳由来神経栄養因子（BDNF）発現に対する三環系抗うつ薬アミトリプチリンの影響2014
- Author(s)
  重藤貴大、中島一恵、梶谷直人、竹林　実、森岡徳光、仲田義啓
- Organizer
  第125回日本薬理学会近畿部会
- Place of Presentation
  岡山（岡山コンベンションセンター）
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-25870461
[Presentation] Tricyclic antidepressant amitriptyline acts on astrocytes leading to the increase in the FGF2 expression: A role of early growth response 1 signaling2014
- Author(s)
  N. KAJITANI, K. HISAOKA, M. OKADA-TSUCHIOKA, M. HOSOI, C. SHIBASAKI, N. MORIOKA, Y. NAKATA, M. TAKEBAYASHI
- Organizer
  44th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC (USA)
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-25870461
[Presentation] 初代培養ラット大脳皮質アストロサイトにおいて三環系抗うつ薬アミトリプチリンはMEK/ERKカスケードを介してBDNF exon mRNAの発現を調節する2013
- Author(s)
  中島一恵
- Organizer
  Neuro2013
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] 7) ラット大脳皮質初代培養アストロサイトのBDNFexon mRNA発現に対するモノアミンの影響2013
- Author(s)
  葛西美穂、中島（久岡）一恵、梶谷直人、重藤貴大、竹林　実、森岡徳光、仲田義啓
- Organizer
  第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会・合同大会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-25870461
[Presentation] 8) ラット大脳皮質初代培養アストロサイトにおいて三環系抗うつ薬amitriptylineはEgr-1を介してFGF-2の発現を増加させる2013
- Author(s)
  梶谷直人、竹林　実、中島一恵、安部裕美、柴崎千代、岡田麻美、森岡徳光、仲田義啓
- Organizer
  第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会・合同大会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-25870461
[Presentation] Distinct regulation of fibroblast growth factor-2 expression by antidepressant and noradrenaline in rat cortical astrocytes2012
- Author(s)
  Kajitani Naoto, Hisaoka-Nakashima Kazue, Morioka Norimitsu, Okada-Tsuchioka Mami, Shibasaki Chiyo, Kaneko Masahiro, Kasai Miho, Nakata Yoshihiro, Takebayashi Minoru
- Organizer
  42th Annual Meeting of Society for Neuroscience
- Place of Presentation
  New Orleans U.S.A
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] 抗うつ薬がラット初代培養アストロサイトの BDNF exon mRNA の発現に及ぼす効果2012
- Author(s)
  金子将大, 久岡一恵, 梶谷直人, 葛西美穂, 岡田麻美, 森岡徳光, 竹林実, 仲田義啓
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] Tricyclic antidepressant amitriptyline indirectly increases the proliferation of adult dentate gyrus-derived neural precursor cells through inducing FGF2 secretion from astrocyte.2012
- Author(s)
  Boku Shuken, Hisaoka-Nakashima Kazue, Nakagawa Shin, Kato Akiko, Kajitani Naoto, Inoue Takeshi, Takebayashi Minoru.
- Organizer
  51th annual meeting of ACNP
- Place of Presentation
  Florida U.S.A.
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] ラット初代培養アストロサイトにおいて抗うつ薬が BDNF exon mRNA 発現に及ぼす作用2012
- Author(s)
  金子将大, 中島(久岡)一恵, 梶谷直人,葛西美穂, 重藤貴大, 森岡徳光, 竹林実,仲田義啓
- Organizer
  第121回日本薬理学会近畿部会
- Place of Presentation
  徳島
- Year and Date
  2012-06-29
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] 三環系抗うつ薬Amitriptylineによるグリア細胞株由来神経栄養因子(GDNF)産生機構におけるマトリックスメタロプロテアーゼ(MMP)の関与2012
- Author(s)
  中島（久岡）一恵
- Organizer
  第22回日本臨床精神神経薬理学会・第42回日本神経精神薬理学会合同年会
- Place of Presentation
  宇都宮市
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] ラット大脳皮質アストロサイトにおいて、amitriptyline による FGF-2の発現は複数の受容体型チロシンキナーゼを介して調節される2012
- Author(s)
  細井茉由, 岡田麻美, 梶谷直人, 矢野遼也, 柴崎千代, 久岡一恵, 森岡徳光, 仲田義啓, 竹林実
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] 三環系抗うつ薬Amitriptyline によるグリア細胞株由来神経栄養因子(GDNF)産生機構におけるマトリックスメタロプロテアーゼ(MMP)の関与2012
- Author(s)
  中島(久岡)一恵, 矢野遼也, 安部裕美,岡田麻美, 柴崎千代, 梶谷直人, 森岡徳光,竹林実, 仲田義啓
- Organizer
  第42回日本神経精神薬理学会合同年会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] 抗うつ薬は初代培養アストロサイトからFGF-2を産生する2011
- Author(s)
  梶谷直人、久岡一恵、金子将大、葛西美穂、矢野遼也、岡田麻美、竹林　実、森岡徳光、仲田義啓
- Organizer
  第119回日本薬理学会近畿部会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] 抗うつ薬は初代培養アストロサイトから FGF-2 を産生する2011
- Author(s)
  梶谷直人, 久岡一恵, 金子将大, 葛西美穂, 矢野遼也, 岡田麻美, 竹林実, 森岡徳光, 仲田義啓
- Organizer
  第119回日本薬理学会近畿部会
- Place of Presentation
  名古屋
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] Antidepressants activate expression of fibroblast growth factor receptor (FGFR) signaling in glial cells: Involvement in glial cell line-derived neurotrophic factor (GDNF) production2011
- Author(s)
  Hisaoka Kazue, Okada-Tsuchioka Mami, Yano Ryouya, Kajitani Naoto, Morioka Norimitsu, Nakata Yoshihiro, Takebayashi Minoru.
- Organizer
  41th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC U.S.A.
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] The increase of FGF-2 expression by amitryptyline and noradrenaline could be mediated different mechanisms in rat primary cultured astrocytes.2011
- Author(s)
  Kajitani Naoto, Hisaoka Kazue, Kaneko Masahiro, Kasai Miho, Yano Ryouya, Okada-Tsuchioka Mami, Morioka Norimitsu, Takebayashi Minoru, Nakata Yoshihiro.
- Organizer
  2nd Congress of Asian College of Neuropsychopharmacology Jointly with 2011 Annual Meeting of KCNP
- Place of Presentation
  Seoul Korea
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] 抗うつ薬によるグリア細胞株由来神経栄養因子(GDNF) 産生機構の解明:マトリックスメタロプロテアーゼ(MMP)の関与2011
- Author(s)
  矢野遼也, 久岡一恵, 細井茉由, 岡田麻美, 柴崎千代, 梶谷直人, 森岡徳光, 竹林実, 仲田義啓
- Organizer
  第120回日本薬理学会近畿部会
- Place of Presentation
  京都
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] Electroconvulsive seizure (ECS) increases thrombospondin-1 (TSP-1) expression in the adult rat hippocampus.2011
- Author(s)
  Okada-Tsuchioka Mami, Takebayashi Minoru, Segawa Masashi, Hosoi Mayu, Kajitani Naoto, Shibasaki Chiyo, Yano Ryouya, Hisaoka Kazue, Morinobu Shigeru
- Organizer
  41th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC U.S.A.
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] 抗うつ薬によるグリア細胞株由来神経栄養因子(GDNF)産生機構の解明：マトリックスメタロプロテアーゼ(MMP)の関与2011
- Author(s)
  矢野遼也、久岡一恵、細井茉由、岡田麻美、柴崎千代、梶谷直人、森岡徳光、竹林　実、仲田義啓
- Organizer
  第120回日本薬理学会近畿部会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] Antidepressants activate expression of fibroblast growth factor receptor (FGFR) signaling in glial cells: Involvement in glial cell line-derived neurotrophic factor (GDNF) production.2011
- Author(s)
  Hisaoka Kazue, Takebayashi Minoru, Okada-Tsuchioka Mami, Yano Ryouya, Kajitani Naoto, Morioka Norimitisu, Nakata Yoshihiro.
- Organizer
  2nd Congress of Asian College of Neuropsychopharmacology Jointly with 2011 Annual Meeting of KCNP
- Place of Presentation
  Seoul Korea
- Data Source
  KAKENHI-PROJECT-23790297
[Presentation] リルゾールはグリア細胞において繊維芽細胞増殖因子受容体(FGFR)を介してグリア細胞株由来神経栄養因子(GDNF)を産生する2010
- Author(s)
  土岡麻美、久岡一恵、矢野遼也、梶谷直人、竹林実
- Organizer
  第29回躁うつ病の薬理・生化学的研究懇話会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] 抗うつ薬はグリアにおいてFGF受容体を活性化してGDNFを産生する2010
- Author(s)
  久岡一恵、竹林実、土岡麻美、矢野遼也、梶谷直人、森岡徳光、仲田義啓
- Organizer
  第117回日本薬理学会近畿部会
- Place of Presentation
  徳島
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] 抗うつ薬はラット初代培養アストロサイトにおいてFGF-2の発現を増加させる2010
- Author(s)
  梶谷直人、久岡一恵、森岡徳光、土岡麻美、矢野遼也、竹林実、仲田義啓
- Organizer
  第13回創薬・薬理フォーラム岡山
- Place of Presentation
  広島
- Year and Date
  2010-08-11
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Antidepressants activate expression of neurotrophic/growth factors in astrocytes.2010
- Author(s)
  Kajitani N, Hisaoka K, Morioka N, Tsuchioka M, Yano R, Nakata Y, Takebayashi M
- Organizer
  40^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Riluzole induces glial cell line-derived neurotrophic factor (GDNF) expression through fibroblast growth factor recerat C6 glioma cells.2010
- Author(s)
  Tsuchioka M, Hisaoka K, Yano R, Shibasaki C, Kajitani N, Takebayashi M
- Organizer
  40^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Riluzole induces glial cell line-derived neurotrophic factor(GDNF)expression through fibroblast growth factor receptor(FGFR)in rat C6 glioma cells.2010
- Author(s)
  Tsuchioka M, Hisaoka K, Yano R, Shibasaki C, Kajitani N, Takebayashi M
- Organizer
  40^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] ラット初代培養アストロサイトにおいて抗うつ薬が神経栄養因子・成長因子の発現に及ぼす影響2010
- Author(s)
  梶谷直人、久岡一恵、森岡徳光、土岡麻美、朴秀賢、中川伸、仲田義啓、竹林実
- Organizer
  第29回躁うつ病の薬理・生化学的研究懇話会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Antidepressants activate expression of neurotrophic/growth factors in astrocytes.2010
- Author(s)
  Kajitani N, Hisaoka K, Morioka N, Tsuchioka M, Yano R, Nakata Y, Takebayashi M
- Organizer
  40^<th> Meeting of Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Anitidepressants activates FGF receptor signaling in glia : Involvement in GDNF production2009
- Author(s)
  Hisaoka K, Tsuchioka M, Takebayashi M
- Organizer
  1st Meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Anitidepressants increase glial cell line-derived neurotrophic factor (GDNF) production through fibroblast growth factorreceptor (FGFR) in glia2009
- Author(s)
  Hisaoka K, Tsuchioka M, Takebayashi M
- Organizer
  39^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Altered blood levels of neuronal adhesion molecule (NCAM) in remitted patients with mood disorders : an involvement of glialcell line derived neurotrophic factor (GDNF) signaling2009
- Author(s)
  Takebayashi M, Hisaoka K, Tsuchioka M
- Organizer
  1st Meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] ラット初代培養アストロサイトにおいて抗うつ薬はFGF-2の発現を増加させる2009
- Author(s)
  梶谷直人、久岡一恵、森岡徳光、中村明陽、土岡麻美、朴秀賢、中川伸、仲田義啓、竹林実
- Organizer
  第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会合同大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] グリアにおける抗うつ薬の新規ターゲット分子同定の試み2009
- Author(s)
  土岡麻美、久岡一恵、仲田義啓、竹林実
- Organizer
  第28回躁うつ病の薬理・生化学的研究懇話会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Riluzole rapidly activates a MEK/ERK/CREB pathway in glial cells : a role for GDNF production2009
- Author(s)
  Tsuchioka M, Hisaoka K, Yano R, Takebayashi M
- Organizer
  1st Meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Increased blood levels of neuronal adhesion molecule (NCAM) in remitted patients with mood disorders : a role of glial cell line derived neurotrophic factor (GDNF) signaling.2009
- Author(s)
  Takebayashi M, Hisaoka K, Tsuchioka M
- Organizer
  39^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago, October
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Anitidepressants increase glial cell line-derived neurotrophic factor (GDNF) production through fibroblast growth factor receptor (FGFR) in glia.2009
- Author(s)
  Hisaoka K, Tsuchioka M, Takebayashi M
- Organizer
  39^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago, October
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] 抗うつ薬はFGF受容体を介してグリアからのGDNF産生を誘導する2008
- Author(s)
  久岡一恵、土岡麻美、長島悟史、藤田康孝、竹林実
- Organizer
  第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Serotonin(5-HT) increases glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor 2 (FGFR2) in C6 glioma cells.2008
- Author(s)
  Tsuchioka M, Hisaoka K, Fujita Y, Uike T, Nakata Y, Takebayashi M
- Organizer
  38^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] 10) ラット大脳皮質培養アストロサイトにおけるamtriptyline誘導性FGF-2産生に対するEGR-1の関与
- Author(s)
  梶谷直人、竹林　実、中島一恵、安部裕美、柴崎千代、岡田麻美、森岡徳光、仲田義啓
- Organizer
  第124回日本薬理学会近畿部会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25870461

1. Morioka Norimitsu (20346505)

# of Collaborated Projects: 7 results

# of Collaborated Products: 58 results
2. NAKATA Yoshihiro (40133152)

# of Collaborated Projects: 4 results

# of Collaborated Products: 31 results
3. 中村庸輝 (60711786)

# of Collaborated Projects: 4 results

# of Collaborated Products: 36 results
4. TAKEBAYASHI Minoru (60304440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 27 results
5. OKADA Mami (30517280)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. 上園保仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 王登莉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakashima kazue 中島 一恵 (久岡 一恵)

HISAOKA-NAKASHIMA KAZUE 中島 一恵

久岡一恵

中島 一恵(久岡一恵) ナカシマ カズエ

NAKASHIMA Kazue 中島 一恵

HISAOKA Kazue 久岡 一恵

久岡 一恵 ヒサオカ カズエ

Research Projects

Research Products

Co-Researchers

海馬ミクログリアサブセットに着目した神経障害性疼痛の病態解明と新規治療法への応用Principal Investigator

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慢性疼痛における核内受容体RORsの機能解析と新規治療戦略への応用

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ミクログリアの細胞老化現象に着目した認知機能障害の発症・増悪機構の解明と応用

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The role of anterior cingulate cortical microglia in pathophysiology of neuropathic pain and novel drug targetsPrincipal Investigator

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Role of nuclear receptor REV-ERB in chronic pain and their potential as therapeutic targets for analgesics

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The role of matrix metalloproteinase in the antidepressant-induced glial cell line-derived neurotrophic factor expression in astrocytesPrincipal Investigator

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Involvement of spinal gap junction in induction and maintenance of chronic pain

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The role of Fibroblast growth factor (FGF) signaling on the novel pharmacological action of antidepressants.Principal Investigator

Principal Investigator

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The effect of antidepressant on Fibroblast growth factor (FGF) receptor, as a novel therapeutic target for major depression.Principal Investigator

Principal Investigator

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Identification of novel targets related to induce expression of neurotrophic factors at antidepressant in glia

Principal Investigator

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[Book] Recent Developments on Depression Research. (Shirayama Y, Chaki S (eds))2009

Author(s)

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Data Source

[Journal Article] Mitochondrial dysfunction and type I interferon signaling induce anxiodepressive-like behaviors in mice with neuropathic pain2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of nuclear receptor RORγ ameliorates mechanical hypersensitivity through the suppression of spinal microglial activation.2023

Nakashima kazue 中島一恵 (久岡一恵)

HISAOKA-NAKASHIMA KAZUE 中島一恵

中島一恵(久岡一恵) ナカシマカズエ

NAKASHIMA Kazue 中島一恵

HISAOKA Kazue 久岡一恵

久岡一恵ヒサオカカズエ