YAMAMOTO YUTAKA 山本豊

… Alternative Names

Researcher Number	20398217
Other IDs
Affiliation (Current)	2022: 熊本大学, 病院, 教授
Affiliation (based on the past Project Information) *help	2015 – 2016: 熊本大学, 大学院生命科学研究部(医), 准教授 2014: 熊本大学, 医学部附属病院, 准教授 2013 – 2014: 熊本大学, 医学部附属病院, その他 2012 – 2014: 熊本大学, 医学部附属病院, 特任准教授 2011: 熊本大学, 生命科学研究部, 助教 … More
Review Section/Research Field	Principal Investigator General surgery Except Principal Investigator General surgery
Keywords	Principal Investigator 乳癌 / 予後因子 / 乳腺外科学 / ユビキチンリガーゼ / Fbw7 / skp2 / トリプルネガティブ乳癌 / Skp2 / 細胞周期 / MACC1 … More Except Principal Investigator 乳癌 / 転写共役因子 / NCoR1 / HDAC6 / ER遺伝子増幅 / HDAC1 / AIB1 / ER遺伝子 / HDAC阻害薬 / 予後予測因子 / 効果予測因子 / 予後予測ツール / 多遺伝子発現 / 予後予測 / 効果予測 / 乳がん / エストロゲンレセプター / 内分泌療法 / ホルモン療法 / ホルモン依存性 / 内分泌療法耐性乳癌 / エストロゲン療法 Less

Detection for predictive factors of estrogen addition and depletion therapy in endocrine therapy-resistant breast cancer
- Principal Investigator
  
  Omoto Yoko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyoto Prefectural University of Medicine
The role of MACC1 in breast cancerPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO YUTAKA
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kumamoto University
Development of quantitative evaluation tool using multigene expression to predict efficacy of endocrine therapy for breast cancer
- Principal Investigator
  
  IWASE Hirotaka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kumamoto University
Study for mechanism of cell cycle regulation by ubiquitin ligase in triple-negative breast cancerPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Yutaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kumamoto University
The study on the sensitization of transcriptional modulator to endocrine therapy for breast cancer
- Principal Investigator
  
  IWASE Hirotaka
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kumamoto University

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] Reproductive Oncology2007
- Author(s)
  Iwase H, Yamamoto Y, Zhang Z
- Total Pages
  14
- Publisher
  Estrogen receptor structure and function in breast cancer pathogenesis.
- Data Source
  KAKENHI-PROJECT-19591513
[Book] Reproductive Oncol2007
- Author(s)
  Iwase H, Yamamoto Y, Zhang Z
- Publisher
  Estrogen receptor structure and function in breast cancer pathogenesis. Editor Fujimoto J
- Data Source
  KAKENHI-PROJECT-19591513
[Journal Article] Clinical significance of monitoring ESR1 mutations in circulating cell-free DNA in estrogen receptor positive breast cancer patients2016
- Author(s)
  63.Takeshita T, Yamamoto Y, Yamamoto-Ibusuki M, Inao T, Sueta A, Fujiwara S, Omoto Y, Iwase H.
- Journal Title
  
  Oncotarget
  
  Volume: 7 Pages: 32504-18
- DOI
  10.18632/oncotarget.8839
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461952, KAKENHI-PROJECT-15K21237, KAKENHI-PROJECT-15K10057
[Journal Article] Immunohistochemical analysis in ethinylestradiol-treated breast cancers after prior long-term estrogen-deprivation therapy.2015
- Author(s)
  Omoto Y, Takeshita T, Yamamoto Y, Yamamoto-Ibusuki M, Hayashi M, Sueta A, Fujiwara S, Taguchi T, Iwase H.
- Journal Title
  
  Springerplus.
  
  Volume: 108 Pages: 1-9
- DOI
  10.1186/s40064-015-0851-8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461952
[Journal Article] Droplet digital polymerase chain reaction assay for screening of ESR1 mutations in 325 breast cancer specimens.2015
- Author(s)
  Takeshita T, Yamamoto Y, Yamamoto-Ibusuki M, Inao T, Sueta A, Fujiwara S, Omoto Y, Iwase H.
- Journal Title
  
  Transl Res.
  
  Volume: 166 Pages: 540-553
- DOI
  10.1016/j.trsl.2015.09.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10057, KAKENHI-PROJECT-26461952
[Journal Article] Differential role of MACC1 expression and its regulation of the　HGF/c‑Met pathway between breast and colorectal cancer2015
- Author(s)
  Sueta A, Yamamoto Y, Yamamoto-Ibusuki M, Hayashi M, Takeshita T, Yamamoto S, Omoto Y, Iwase A
- Journal Title
  
  International Journal of Oncology
  
  Volume: 46 Pages: 2143-2153
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591909
[Journal Article] C6ORF97-ESR1 breast cancer susceptibility locus: influence on progression and survival in breast cancer patients.2015
- Author(s)
  Yamamoto-Ibusuki M, Yamamoto Y, Fujiwara S, Sueta A, Yamamoto S, Hayashi M, Tomiguchi M, Takeshita T, Iwase H
- Journal Title
  
  Eur J Hum Genet
  
  Volume: Epub Pages: 2143-53
- DOI
  10.1038/ejhg.2014.219
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591910, KAKENHI-PROJECT-15K21237
[Journal Article] Clinical benefit of sequential use of endocrine therapies for metastatic breast cancer.2015
- Author(s)
  Iwase H, Yamamoto Y.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: Epub
- DOI
  10.1007/s10147-015-0795-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591910
[Journal Article] Clinical Significance of pretherapeutic Ki67 as a predictive parameter for response to neoadjuvant chemotherapy in breast cancer; is it equally useful across tumor subtype2014
- Author(s)
  Sueta A, Yamamoto Y, Hayashi M, Yamamoto S, Inao T, Ibusuki M, MUrakami M, Iwase H
- Journal Title
  
  Surgery
  
  Volume: Epub
- DOI
  10.1016/j.surg.2014.01.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591910
[Journal Article] A complehensove analysis of Aurora A; transcript levels are most reliable in association with proliferation and prognosis in breast cancer2013
- Author(s)
  Yamamoto S, Yamamoto-Ibusuki M, yamamoto Y, Fujiwara S, Iwase H
- Journal Title
  
  BMC cancer
  
  Volume: 13 Pages: 217-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591910
[Journal Article] Comparison of prognostic values between combined immunohistochemical score of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67 and the corresponding gene expression score in breast cancer.2012
- Author(s)
  Yamamoto-Ibusuki M, Yamamoto Y, Yamamoto S, Fujiwara S, Fu P, Honda Y, Iyama K, Iwase H.
- Journal Title
  
  Mod Pathol
  
  Volume: 26 Pages: 79-86
- Data Source
  KAKENHI-PROJECT-24591910
[Journal Article] High survivin mRNA expression is a predictor of poor prognosis in breast cancer: a comparative study at the mRNA and protein level.2012
- Author(s)
  Xu C, Yamamoto-Ibusuki M, Yamamoto Y, Yamamoto S, Fujiwara S, Murakami K, Okumura Y, Yamaguchi L, Fujiki Y, Iwase H.
- Journal Title
  
  Breast Cancer
  
  Volume: Epub ahead of prinｔ Pages: 20-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591910
[Journal Article] Association of ErbB1-4 expression in invasive breast cancer with clinicopathological characteristics and prognosis.2012
- Author(s)
  Fujiwara S, Ibusuki M, Yamamoto S, Yamamoto Y, Iwase H.
- Journal Title
  
  Breast Cancer.
  
  Volume: Epub ahead of prinｔ Pages: 20-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591910
[Journal Article] Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients2011
- Author(s)
  Ibusuki M, Yamamoto Y, Shinriki S, Ando Y, Iwase H
- Journal Title
  
  Cancer Sci
  
  Volume: 102(2) Pages: 439-45
- NAID
  10029290404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591671
[Journal Article] Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients.2011
- Author(s)
  Ibusuki M, Yamamoto Y, Shinriki S, et al.
- Journal Title
  
  Cancer Science
  
  Volume: 102 Pages: 439-445
- NAID
  10029290404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591671
[Journal Article] Clinicopathological features and treatment strategy for triple-negative breast cancer.2010
- Author(s)
  Yamamoto Y, Iwase H
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 15 Pages: 341-351
- NAID
  10026601200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591671
[Journal Article] Clinicopathological features and treatment strategy for triple-negative breast cancer2010
- Author(s)
  Yamamoto Y, Iwase H
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 15(4) Pages: 341-51
- NAID
  10026601200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591671
[Journal Article] Clinical significance of basal-like subtype in triple-negative breast cancer2009
- Author(s)
  Yamamoto Y, Ibusuki M, Iwase H, et al
- Journal Title
  
  Breast Cancer VOL.16
  
  Pages: 260-270
- NAID
  10027254696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591671
[Journal Article] Estrogen receptor aloha gene ESR1 amplification may predict endocrine therapy responsiveness in breast cancer patients2009
- Author(s)
  Tomita S, Zhang Z, Nakano M, Ibusuki M, Kawasoe T, Yamamoto Y, Iwase H
- Journal Title
  
  Cancer Sci 100
  
  Pages: 1012-1017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591513
[Journal Article] Safety profiles of aromatase inhibitors and selective estrogen-receptor modulators in the treatment of early breast cancer2008
- Author(s)
  Yamamoto Y, Iwase H
- Journal Title
  
  Int J Clin Oncol 13
  
  Pages: 384-394
- NAID
  10023919405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591513
[Journal Article] Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasion2008
- Author(s)
  Okumura, Yamamoto Y, Zhang Z, Toyama T, Kawasoe T, Ibusuki M, Honda Y, Iyama K, Yamashita H, Iwase H
- Journal Title
  
  BMC cancer E-pub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591513
[Journal Article] 内分泌療法の効果予測-遺伝子プロファイリングから-2007
- Author(s)
  岩瀬弘敬、山本豊
- Journal Title
  
  日本臨床 65
  
  Pages: 549-554
- Data Source
  KAKENHI-PROJECT-19591513
[Journal Article] Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer.2007
- Author(s)
  Yamamoto Y, Ibusuki M, Iwase H
- Journal Title
  
  Breast Cancer Res Treat E-pub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591513
[Presentation] Clinical significance of sequential measurements of ESR1 mutations in plasma cell-free DNA in estrogen receptor positive recurrent metastatic breast cancer patients.2016
- Author(s)
  Takeshita T, Yamamoto Y, Yamamoto-Ibusuki M, Sueta A, Tomiguchi M and Iwase H.
- Organizer
  The 39th San Antonio Breast Cancer Symposium
- Place of Presentation
  San Antonio, TX, USA
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461952
[Presentation] Clinical significance of ESR1 mutations using droplet digital polymerase chain reaction assay in 325 breast cancer samples.2015
- Author(s)
  Takeshita T, Yamamoto Y, Yamamoto-Ibusuki M, Inao T, Sueta A, Fujiwara S, Iwase H
- Organizer
  The 38th San Antonio Breast Cancer Symposium
- Place of Presentation
  San Antonio, TX
- Year and Date
  2015-12-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461952
[Presentation] Clinical significance of ESR1 mutations by cell-free DNA in recurrent/metastatic breast cancer.2015
- Author(s)
  Takeshita T, Yamamoto Y, Yamamoto-Ibusuki M, Inao T, Sueta A, Fujiwara S, Iwase H
- Organizer
  Advances in Breast Cancer Research
- Place of Presentation
  Bellevue, Washington
- Year and Date
  2015-10-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461952
[Presentation] ESR1 gene alterations in the metastatic breast cancer with resistance to aromatase inhibitor.2015
- Author(s)
  Iwase H, Takeshita T, Yamamoto-Ibusuki M, Inao T, Sueta A, Fujiwara S, Yamamoto Y
- Organizer
  Advances in Breast Cancer Research
- Place of Presentation
  Bellevue, Washington
- Year and Date
  2015-10-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461952
[Presentation] 長期にアロマターゼ阻害薬を投与したER陽性再発乳癌患者におけるEE2 治療前後の遺伝子発現の免染での検討2014
- Author(s)
  大本陽子、竹下卓志、指宿睦子、藤原沙織、末田愛子、林　光博、山本聡子、稲尾瞳子、奥村恭博、村上敬一、山本　豊、岩瀬弘敬
- Organizer
  第22回日本乳癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2014-07-10
- Data Source
  KAKENHI-PROJECT-26461952
[Presentation] ER陽性HER2陰性乳癌の予後予測ツールとしてのKu-integrated prognostic scoreの開発2013
- Author(s)
  山本　豊
- Organizer
  第21回日本乳癌学会学術総会
- Place of Presentation
  浜松、アクトシティ
- Invited
- Data Source
  KAKENHI-PROJECT-24591910
[Presentation] Luminal型乳癌における包括的予後スコア創出の試みとその有用性2012
- Author(s)
  指宿睦子、山本　豊、山本聡子、藤原沙織、村上敬一、岩瀬弘敬
- Organizer
  第20回日本乳癌学会学術総会
- Place of Presentation
  熊本　ホテル日航熊本
- Invited
- Data Source
  KAKENHI-PROJECT-24591910
[Presentation] Tha advantage of copy number variation assay of ERBB2 using FFPE specimens: a comprehensive study2012
- Author(s)
  Ibusuki M,Yamamoto Y, Yamamoto S, Fujiwara S, Iwase H
- Organizer
  The 20th Annual Meeting of The Japanese Breast Cancer Society
- Place of Presentation
  Kumamoto,Japan,Hotel Nikko Kumaoto
- Data Source
  KAKENHI-PROJECT-24591910
[Presentation] Redu ced expression of ubiquitin ligase FB XW7 mRNA is associated with poor prog nosis in breast cancer patients2011
- Author(s)
  Ibusuki M, Yamamoto Y, Iwase H
- Organizer
  Adva nces in Breast Cancer Research
- Place of Presentation
  サンフランシスコ、米国
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-21591671
[Presentation] Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients2011
- Author(s)
  指宿睦子、山本豊、岩瀬弘敬
- Organizer
  Advances in Breast Cancer Research
- Place of Presentation
  米国サンフランシスコ
- Data Source
  KAKENHI-PROJECT-21591671
[Presentation] NCoR1蛋白発現は進行再発乳癌における内分泌療法の効果と関連する2008
- Author(s)
  富田さおり、山本豊、岩瀬弘敬
- Organizer
  日本乳癌学会
- Place of Presentation
  大阪
- Year and Date
  2008-09-26
- Data Source
  KAKENHI-PROJECT-19591513
[Presentation] 乳癌におけるErα遺伝子増幅の検討2008
- Author(s)
  富田さおり、山本豊、岩瀬弘敬
- Organizer
  第9回ホルモンと癌研究会
- Place of Presentation
  岐阜
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-19591513
[Presentation] Ethinylestradiol treatment downregulates ER and upregulates PgR; Immunohistochemical analysis in postmenopausal breast cancer tissues after prior long-term estrogen-deprivation therapy
- Author(s)
  Hirotaka Iwase, Yoko Omoto, Takeshi Takeshita, Mutsuko Yamamoto-Ibusuki, Mitsuhiro Hayashi, Aiko Sueta, Saori Fujiwara, Yutaka Yamamoto
- Organizer
  23rd San Antonio Breast Cancer Syposium
- Place of Presentation
  San Antonio
- Year and Date
  2014-12-10 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-24591910
[Presentation] Gene expression analysis in ethinylestradiol-treated breast cancers following long-term estrogen-deprivation therapy
- Author(s)
  Hirotaka Iwase, Takashi Takeshita, Aiko Sueta, Mai Tomiguchi,Yutaka Yamamoto
- Organizer
  第76回　日本癌学会学術総会
- Place of Presentation
  横浜、English Oral Session: Breast Cancer
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24591910
[Presentation] A role of MACC1 expression and its regulation of the HGF/c-Met pathway in breast cancer
- Author(s)
  Aiko S, Yamamoto Y, Hayashi M, Takeshita T, Yamamoto-Ibusuki M, Iwase H
- Organizer
  37th　San Antonio Breast Cancer symposium
- Place of Presentation
  San Antonio, TX, USA
- Year and Date
  2014-12-06 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-24591909

1. IWASE Hirotaka (40211065)

# of Collaborated Projects: 5 results

# of Collaborated Products: 36 results
2. IBUSUKI Mutsuko (30448526)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
3. Omoto Yoko (80642561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 田口哲也 (80243260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

YAMAMOTO YUTAKA 山本 豊

YAMAMOTO Yutaka 山本 豊

Research Projects

Research Products

Co-Researchers

Detection for predictive factors of estrogen addition and depletion therapy in endocrine therapy-resistant breast cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of MACC1 in breast cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of quantitative evaluation tool using multigene expression to predict efficacy of endocrine therapy for breast cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for mechanism of cell cycle regulation by ubiquitin ligase in triple-negative breast cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study on the sensitization of transcriptional modulator to endocrine therapy for breast cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Reproductive Oncology2007

Author(s)

Total Pages

Publisher

Data Source

[Book] Reproductive Oncol2007

Author(s)

Publisher

Data Source

[Journal Article] Clinical significance of monitoring ESR1 mutations in circulating cell-free DNA in estrogen receptor positive breast cancer patients2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunohistochemical analysis in ethinylestradiol-treated breast cancers after prior long-term estrogen-deprivation therapy.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Droplet digital polymerase chain reaction assay for screening of ESR1 mutations in 325 breast cancer specimens.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential role of MACC1 expression and its regulation of the HGF/c‑Met pathway between breast and colorectal cancer2015

Author(s)

Journal Title

Data Source

[Journal Article] C6ORF97-ESR1 breast cancer susceptibility locus: influence on progression and survival in breast cancer patients.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical benefit of sequential use of endocrine therapies for metastatic breast cancer.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Significance of pretherapeutic Ki67 as a predictive parameter for response to neoadjuvant chemotherapy in breast cancer; is it equally useful across tumor subtype2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A complehensove analysis of Aurora A; transcript levels are most reliable in association with proliferation and prognosis in breast cancer2013

Author(s)

YAMAMOTO YUTAKA 山本豊

YAMAMOTO Yutaka 山本豊

[Journal Article] Differential role of MACC1 expression and its regulation of the　HGF/c‑Met pathway between breast and colorectal cancer2015