Asada Hidetsugu 浅田秀基

… Alternative Names

浅田秀基アサダヒデツグ

ASADA Hidetsugu 浅田秀基

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Researcher Number	20399041
Other IDs	https://orcid.org/0000-0001-6255-4728
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定准教授 2025: 京都府立医科大学, 医学(系)研究科(研究院), 研究員
Affiliation (based on the past Project Information) *help	2022 – 2025: 京都大学, 医学研究科, 特定准教授 2019 – 2020: 京都大学, 医学研究科, 特定講師 2018: 京都大学, 医学研究科, 特定助教 2012 – 2015: 京都大学, 医学(系)研究科(研究院), 助教 2014: 京都大学, 大学院医学研究科, 研究員 … More 2012: 京都大学, 大学院・医学研究科, 特定助教 2010 – 2012: 京都大学, 医学研究科, 研究員 2007: Kyoto Prefectural University of Medicine, 医学部, 博士研究員 Less
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 48040:Medical biochemistry-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Dermatology Except Principal Investigator Structural biochemistry / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Transformative Research Areas, Section (II) / Basic Section 43020:Structural biochemistry-related
Keywords	Principal Investigator Gタンパク質共役受容体 / 構造解析 / X線結晶構造解析 / GPCR / バイスシグナリング / 単粒子解析 / クライオ電子顕微鏡 / バイアスシグナリング / グレリン受容体 / 膜タンパク質 … More / アンジオテンシン受容体 / 構造認識抗体 / X線結晶構造 / アンジオテンシン / 膜蛋白質 / 共結晶 / 結晶化 / 抗体 / 構造生物 / 免疫学 / 癌 / DDS / RNAi / 免疫療法 / サイトカイン / RNAインタフェレンス / 分子標的治療 / 悪性黒色腫 … More Except Principal Investigator X線結晶構造解析 / X線自由電子レーザー / Gタンパク質共役型受容体 / GPCR / 受容体 / 動的構造 / 時分割結晶構造解析 / 人工受容体 / Ｘ線自由電子レーザー / ロドプシン / シリアルフェムト秒結晶構造解析 / ヒスタミン / 結晶構造解析 / 花粉症 / アレルギー / G蛋白質共役型受容体 / 構造解析 / 膜タンパク質 / X線結晶解析 Less

プロテアーゼ活性化受容体の構造に基づく合理的新規抗凝固薬の探索Principal Investigator
- Principal Investigator
  
  浅田秀基
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto University
デザイナーリガンドで制御可能な受容体の創成および生成的デザイン
- Principal Investigator
  
  清中茂樹
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Nagoya University
細胞膜受容体の動的構造解析と活性化機構の解明
- Principal Investigator
  
  南後恵理子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tohoku University
グレリン受容体のシグナル伝達選択機構の構造基盤Principal Investigator
- Principal Investigator
  
  浅田秀基
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kyoto University
Activation mechanism of G protein-coupled receptors by X-ray free electron lasers
- Principal Investigator
  
  Nango Eriko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Tohoku University
  Institute of Physical and Chemical Research
Crystallization of Angiotensin receptor type 2 with its specific antibodyPrincipal Investigator
- Principal Investigator
  
  Asada Hidetsugu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Structure determination of histamine H1 receptor
- Principal Investigator
  
  SHIMAMURA Tatsuro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
Challenges for the structure determination of GPCR active conformation
- Principal Investigator
  
  SHIMAMURA Tatsuro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
Crystallization of GPCR and its specific antibodyPrincipal Investigator
- Principal Investigator
  
  ASADA Hidetsugu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
RNA interference-based therapeutic molecular targeting strategy using nano drug delivery systems to eradicate malignant melanomaPrincipal Investigator
- Principal Investigator
  
  SABURO Kishimoto, 浅田秀基
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kyoto Prefectural University of Medicine

All 2024 2020 2015 2013 2012 2011 2010 2008 2007

All Journal Article Presentation Book

[Book] Towards the Crystal Structure Determination of Muscarinic Acetylcholine Receptors2015
- Author(s)
  Suno, R., H. Asada and T. Kobayashi
- Total Pages
  13
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-25293068
[Journal Article] Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A2A receptor2024
- Author(s)
  Araya Tsuyoshi、Matsuba Yuya、Suzuki Harufumi、Doura Tomohiro、Nuemket Nipawan、Nango Eriko、Yamamoto Masaki、Im Dohyun、Asada Hidetsugu、Kiyonaka Shigeki、Iwata So
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 695 Pages: 149393-149393
- DOI
  10.1016/j.bbrc.2023.149393
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0099, KAKENHI-PLANNED-19H05777, KAKENHI-PLANNED-19H05781, KAKENHI-PROJECT-19H00923
[Journal Article] Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone2020
- Author(s)
  Im Dohyun、Inoue Asuka、Fujiwara Takaaki、Nakane Takanori、Yamanaka Yasuaki、Uemura Tomoko、Mori Chihiro、Shiimura Yuki、Kimura Kanako Terakado、Asada Hidetsugu、Nomura Norimichi、Tanaka Tomoyuki、Yamashita Ayumi、Nango Eriko、Tono Kensuke、Kadji Francois Marie Ngako、Aoki Junken、Iwata So、Shimamura Tatsuro
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41467-020-20221-0
- NAID
  120006943309
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21392, KAKENHI-PLANNED-19H05781, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-18H02394, KAKENHI-PROJECT-18K05334, KAKENHI-ORGANIZER-19H05776, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-18H02388
[Journal Article] Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharoroyces cerevisiae.2012
- Author(s)
  Shiroishi M., et al.
- Journal Title
  
  Micorb, Cell Fact.
  
  Volume: 11 Issue: 1 Pages: 78-78
- DOI
  10.1186/1475-2859-11-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J40150, KAKENHI-PROJECT-22570114, KAKENHI-PROJECT-22590270, KAKENHI-PROJECT-23370049, KAKENHI-PROJECT-23657074, KAKENHI-PROJECT-23770123, KAKENHI-PROJECT-24370044, KAKENHI-PROJECT-24659132, KAKENHI-PUBLICLY-24121715
[Journal Article] Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist2012
- Author(s)
  Haga, K*., A. C. Kruse*,H. Asada*, T. Yurugi-Kobayashi, M. Shiroishi, C. Zhang, W. I. Weis, T. Okada, B. K. Kobilka, T. Haga, and T. Kobayashi
- Journal Title
  
  These authors contributed equally to this work
  
  Volume: 482 Pages: 547-551
- NAID
  120003752107
- Data Source
  KAKENHI-PROJECT-22590270
[Journal Article] Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist2012
- Author(s)
  Haga K., et al
- Journal Title
  
  Nature
  
  Volume: 482 Issue: 7386 Pages: 547-551
- DOI
  10.1038/nature10753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J40150, KAKENHI-PROJECT-22590270, KAKENHI-PROJECT-22659059, KAKENHI-PROJECT-23370049
[Journal Article] Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium2011
- Author(s)
  Tokuda, N., K. Igarashi, T. Shimamura, T. Yurugi-Kobayashi, M. Shiroishi, K. Ito, T. Sugawara, H. Asada, T. Murata, N. Nomura, S. Iwata, and T. Kobayashi
- Journal Title
  
  Protein Expr Purif
  
  Volume: 79 Pages: 81-87
- NAID
  120003255719
- Data Source
  KAKENHI-PROJECT-22590270
[Journal Article] Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis2011
- Author(s)
  Asada, H., T. Uemura, T. Yurugi-Kobayashi, M. Shiroishi, T. Shimamura, H. Tsujimoto, K. Ito, T. Sugawara, T. Nakane, N. Nomura, T. Murata, T. Haga, S. Iwata, and T. Kobayashi
- Journal Title
  
  Microb Cell Fact
  
  Volume: 10 Pages: 24-24
- Data Source
  KAKENHI-PROJECT-22590270
[Journal Article] Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis2011
- Author(s)
  Asada, H., Uemura, T., Yurugi-Kobayashi, T., Shiroishi, M., Shimamura, T., Tsujimoto, H., Ito, K., Sugawara, T., Nakane, T., Nomura, N., Murata, T., Haga, T., Iwata, S., Kobayashi, T
- Journal Title
  
  Microbial Cell Factories
  
  Volume: 10 Issue: 1 Pages: 24-24
- DOI
  10.1186/1475-2859-10-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04341, KAKENHI-PROJECT-21370043, KAKENHI-PROJECT-22570114, KAKENHI-PROJECT-22590270
[Journal Article] Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion : case of a nonglycosylated mutant of miraculin, a taste-modifying protein2011
- Author(s)
  Ito, K., T.Sugawara, A.Koizumi, K.Nakajima, A.Shimizu-Ibuka, M.Shiroishi, H.Asada, T.Yurugi-Kobayashi, T.Shimamura, T.Asakura, T.Misaka, S.Iwata, T.Kobayashi, K.Abe
- Journal Title
  
  Biotechnology Letters
  
  Volume: Vol.33 Issue: 1 Pages: 103-107
- DOI
  10.1007/s10529-010-0399-1
- NAID
  120002723145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590270, KAKENHI-PROJECT-23248058
[Journal Article] Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium2011
- Author(s)
  Tokuda N, Igarashi K, Shimamura T(co-1st author), Yurugi-Kobayashi T, Shiroishi M, Ito K, Sugawara T, Asada H, Murata T, Nomura N, Iwata S, Kobayashi T.
- Journal Title
  
  Protein. Expr. Purif.
  
  Volume: 79(1) Issue: 1 Pages: 81-7
- DOI
  10.1016/j.pep.2011.04.006
- NAID
  120003255719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370043, KAKENHI-PROJECT-22570114, KAKENHI-PROJECT-22590270, KAKENHI-PROJECT-23657074
[Journal Article] Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein2011
- Author(s)
  Ito, K., T. Sugawara, A. Koizumi, K.Nakajima, A. Shimizu-Ibuka, M. Shiroishi, H. Asada, T. Yurugi-Kobayashi, T. Shimamura, T. Asakura, T. Misaka, S. Iwata, T. Kobayashi, and K. Abe
- Journal Title
  
  Biotechnol Lett
  
  Volume: 33 Pages: 103-107
- NAID
  120002723145
- Data Source
  KAKENHI-PROJECT-22590270
[Journal Article] Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin2010
- Author(s)
  Ito, K., T. Sugawara, A. Koizumi, K. Nakajima, A. Shimizu-Ibuka, M. Shiroishi, H. Asada, T. Yurugi-Kobayashi, T. Shimamura, T. Asakura, K. Masuda, M. Ishiguro, T. Misaka, S. Iwata, T. Kobayashi, and K. Abe
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1800 Pages: 986-992
- Data Source
  KAKENHI-PROJECT-22590270
[Journal Article] Pleiotrophic Functions of Epstein-Barr Virus Nuclear Antigen-1 (EBNA-1) and oriP Differentially Contribute to the Efficacy of Transfection/expression of Exogenous Gene in Mammalian Cells2008
- Author(s)
  Kishida, T., H. Asada, K. Kubo, Y. Sato, M. Shin-Ya, J. Imanishi, K. Yoshikawa & O. Mazda
- Journal Title
  
  J. Biotechnol 133 (2)
  
  Pages: 201-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591323
[Journal Article] IL-21 induces inhibitor of differentiation 2 (Id2) and leads to complete abrogation of anaphylaxis in mice2007
- Author(s)
  Kishida, T., Y. Hiromura, M. Shin-Ya, H. Asada, H. Kuriyama, M. Sugai, A. Shimizu, Y. Yokota, T. Hama, J. Imanishi, Y. Hisa & O. Mazda
- Journal Title
  
  J. Immunol 179 (12)
  
  Pages: 8554-8561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591323
[Presentation] Crystallization of Angiotensin receptor type 2 with its specific antibody2013
- Author(s)
  浅田秀基
- Organizer
  GPCR workshop 2013
- Place of Presentation
  Maui, Hawaii
- Data Source
  KAKENHI-PROJECT-25293068
[Presentation] The expression and purification of Angiotensin II receptor type 2 toward crystal structural biology2011
- Author(s)
  浅田秀基
- Organizer
  GPCR workshop 2011
- Place of Presentation
  Hyatt Regency Maui Resort & Spa (Hawaii, USA)
- Year and Date
  2011-12-05
- Data Source
  KAKENHI-PROJECT-22590270
[Presentation] アンジオテンシンタイプ2受容体の発現・精製から結晶構造解析へ向けて(Expression and purification of angiotensin receptor type 2 for the determination of crystal structure)2011
- Author(s)
  浅田秀基
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22590270
[Presentation] Expression and purification of Angiotensin receptor type 2 and production of structure recognition antibody for structural biology2010
- Author(s)
  浅田秀基
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸国際会議場(神戸)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22590270

1. SABURO Kishimoto (90079913)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. SHIROISHI Mitsunori (00380527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. SHIMAMURA Tatsuro (90391979)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. OGASAWARA Satoshi (30546685)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Nango Eriko (90376947)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 清中茂樹 (90422980)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. HINO Tomoya (40373360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. IWATA So (60452330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 椎村祐樹 (40551297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 堤尚孝 (70963495)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 林到ヒョン (50721883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 保坂俊彰 (40462725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 熊坂崇 (30291066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. LEURS Rob

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小林拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Asada Hidetsugu 浅田 秀基

浅田 秀基 アサダ ヒデツグ

ASADA Hidetsugu 浅田 秀基

Research Projects

Research Products

Co-Researchers

プロテアーゼ活性化受容体の構造に基づく合理的新規抗凝固薬の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

デザイナーリガンドで制御可能な受容体の創成および生成的デザイン

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞膜受容体の動的構造解析と活性化機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

グレリン受容体のシグナル伝達選択機構の構造基盤Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Activation mechanism of G protein-coupled receptors by X-ray free electron lasers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Crystallization of Angiotensin receptor type 2 with its specific antibodyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure determination of histamine H1 receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Challenges for the structure determination of GPCR active conformation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Crystallization of GPCR and its specific antibodyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RNA interference-based therapeutic molecular targeting strategy using nano drug delivery systems to eradicate malignant melanomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Towards the Crystal Structure Determination of Muscarinic Acetylcholine Receptors2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A2A receptor2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone2020

Author(s)

Journal Title

DOI

Asada Hidetsugu 浅田秀基

浅田秀基アサダヒデツグ

ASADA Hidetsugu 浅田秀基