FUKUSHIMA Koji 福島耕治

Researcher Number	20400476
Affiliation (based on the past Project Information) *help	2011: Tohoku University, 大学病院, 助教 2007 – 2011: 東北大学, 病院, 助教 2006: TOHOKU UNIVERSITY, HOSPITAL, Research associate, 病院・助手
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator autophagy / Kupffer細胞 / インスリン抵抗性 / 肝臓 / 炎症 / TNF / 脂肪酸 / NASH / NAFLD / 脂肪性肝疾患 … More / 脂肪合成 / TNFα / クッパー細胞 / トランス脂肪酸 / 非アルコール性脂肪性肝炎 / 肝臓学 … More Except Principal Investigator 原発性胆汁性肝硬変 / liver cirrhosis / hapatocellular carcinoma / liver failure / natal immunity / branched chain amino acid / dendritic cell / 分岐鎖アミノ酸 / 肝硬変 / 肝細胞癌 / 肝不全 / 自然免疫 / 分枝鎖アミノ酸 / 樹状細胞 / ORF / モデルマウス / 胆汁うっ滞 / 胆管上皮細胞 / プロファイリング / レトロウイルス / 次世代シーケンサー / 肝臓学 / 等電点電気泳動 / 動物モデル / MALDI-TOFMS / 胆管細胞 / プロテオミクス Less

肝脂肪蓄積と炎症および細胞ストレスPrincipal Investigator
- Principal Investigator
  
  福島耕治
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Evaluation of endogenous retroviral genes at human cholestatic liver diseases
- Principal Investigator
  
  UENO Yoshiyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Involvement of fatty acids and Kupffer cells for development of liver diseasePrincipal Investigator
- Principal Investigator
  
  FUKUSHIMA Koji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Cell biological analysis for studying the target-specific mechanism involved in immune-mediated cholangitis.
- Principal Investigator
  
  UENO Yoshiyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Extracellular Branched-chain Amino Acids, Especially Valine, Regulate Maturation and Function of Monocyte-derived Dendritic Cells
- Principal Investigator
  
  UENO Yoshiyuki, 菅野記豊
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  TOHOKU UNIVERSITY

All 2010 2009 2008 2007

All Journal Article Presentation Book

[Book] Pathophysiology of the intrahepatic biliary epithelium2008
- Author(s)
  Fukushima K, and Ueno, Y
- Publisher
  Transworld Research Network
- Data Source
  KAKENHI-PROJECT-19590744
[Journal Article] Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice.2010
- Author(s)
  小原範之、福島耕治
- Journal Title
  
  Journal of Hepatology
  
  Volume: 53(2) Pages: 326-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590755
[Journal Article] Possible involvement and the mech anisms of excess trans-fatty acid consumptio n in severe NAFLD in mice.2010
- Author(s)
  小原範之, 福島耕治, 上野義之
- Journal Title
  
  Journal of Hepa tology 53(2)
  
  Pages: 326-334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590755
[Journal Article] Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice2010
- Author(s)
  Obara, N, Fukushima, K, Ueno, Y, et al
- Journal Title
  
  J of Hepatology (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590755
[Journal Article] Treatment of Primary Biliary Cirrhosis : A new challenge?2010
- Author(s)
  Fukushima K, Ueno Y, Shimosegawa T.
- Journal Title
  
  Hepatol Res 40
  
  Pages: 61-68
- NAID
  10027406756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590822
[Journal Article] Treatment of Primary Biliary Cirrhosis : A new challenge?2010
- Author(s)
  Fukushima K, Ueno Y, Shimosegawa T
- Journal Title
  
  Hepatology research : the official journal of the Japan Society of Hepatology
  
  Volume: 40(1) Pages: 61-68
- NAID
  10027406756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590822
[Journal Article] Compensatory role of inducible annexin A2 for impaired biliary epithelial anion-exchange activity of inflammatory cholangiopathy2009
- Author(s)
  Kido O, Fukushima K, Ueno Y, Inoue J, Jefferson DM, Shimosegawa T
- Journal Title
  
  Laboratory investigation
  
  Pages: 1374-1386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590822
[Journal Article] Compensatory role of inducible annexin A2 for impaired biliary epithelial anion-exchange activity of inflammatory cholangiopathy.2009
- Author(s)
  Kido O, Fukushima K, Ueno Y, Inoue J, Jefferson DM, Shimosegawa T.
- Journal Title
  
  Lab Invest 89
  
  Pages: 1374-1386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590822
[Journal Article] クッパー細胞に対する遊離脂肪酸の生理学的作用2008
- Author(s)
  小原範之、福島耕治、上野義之
- Journal Title
  
  薬理と治療 36
- Data Source
  KAKENHI-PROJECT-20590755
[Journal Article] クッパー細胞に対する遊離脂肪酸の生理学的作用2008
- Author(s)
  小原範之, 福島耕治, 上野義之, 下瀬川徹
- Journal Title
  
  Jpn Pharmacol Ther 36(s2)
- Data Source
  KAKENHI-PROJECT-20590755
[Journal Article] Amniotic epithelial cell-derived cholangiocytes in experimental cholestatic ductal hyperplasia2007
- Author(s)
  Moritoki Y, Ueno Y, Kanno N, Yamagiwa Y, Fukushima K, Gershwin ME, Shimosegawa T
- Journal Title
  
  Hepatol Res 37
  
  Pages: 286-294
- NAID
  10020164395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590744
[Journal Article] Autoimmune cholangitis in NOD.c3c4 mice is associated with cholangiocyte-specific Fas antigen deficiency2007
- Author(s)
  Nakagome Y, Ueno Y, Kogure T, Fukushima K, Moritoki Y, Ridgway WM, Eric Gershwin M, Shimosegawa T
- Journal Title
  
  J Autoimmun 29
  
  Pages: 20-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590744
[Journal Article] Bioinformatic approach for cholangiocyte pathophysiology.2007
- Author(s)
  Ueno Y, Fukushima K, Nakagome Y, Kido O and Shimosegawa T
- Journal Title
  
  Hepatol Res 37Suppl3
- NAID
  10019797315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590744
[Journal Article] Autoimmune cholangitis in NOD.c3c4 mice is associated with cholangiocyte-specific Fas antigen deficiency.2007
- Author(s)
  Nakagome Y, Ueno Y, Kogure T, Fukushima K, Moritoki Y, Ridgway WM, et. al.
- Journal Title
  
  J Autoimmun 29
  
  Pages: 20-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590744
[Journal Article] Bioinformatic approach for cholangiocyte pathophysiology2007
- Author(s)
  Ueno Y, Fukushima K, Nakagome Y, Kido O, Shimosegawa T
- Journal Title
  
  Hepatol Res 37 Suppl
- NAID
  10019797315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590744
[Journal Article] Mapping of a disease susceptibility locus in the HLA region for Primary Biliary Cirrhosis in Japan2007
- Author(s)
  Yahagi K, Ueno Y, Nomura E, Fukushima K, Moritoki Y, Kogure T, Kojima Y, Negoro K, Kinouchi Y, Shimosegawa T
- Journal Title
  
  Hepatol Res 37
  
  Pages: 270-275
- NAID
  10020164315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590744
[Presentation] トランス脂肪酸と肝関連指標に関する検討(フェローシップ賞受賞者講演)2010
- Author(s)
  福島耕治、小原範之、上野義之
- Organizer
  日本静脈経腸栄養学会
- Place of Presentation
  幕張
- Year and Date
  2010-02-25
- Data Source
  KAKENHI-PROJECT-20590755
[Presentation] トランス脂肪酸高含有特殊脂肪食による脂肪性肝疾患の惹起と発症機序2010
- Author(s)
  小原範之、福島耕治、上野義之
- Organizer
  日本消化器病学会
- Place of Presentation
  山形
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-20590755
[Presentation] トランス脂肪酸と肝関連指標に関する検討2010
- Author(s)
  福島耕治、小原範之、上野義之
- Organizer
  日本静脈経腸栄養学会
- Place of Presentation
  千葉・幕張
- Year and Date
  2010-02-26
- Data Source
  KAKENHI-PROJECT-20590755
[Presentation] トランス脂肪酸マウスモデルの病態解析2010
- Author(s)
  福島耕治
- Organizer
  日本消化器病学会・肝臓学会・消化吸収学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20590755
[Presentation] トランス脂肪酸マウスモデルの病態解析2010
- Author(s)
  福島耕治、小原範之、上野義之
- Organizer
  日本肝臓学会、消化器病学会、消化吸収学会
- Place of Presentation
  横浜
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20590755
[Presentation] Fatty liver disease model caused by long-term feeding of trans-fatty acids2009
- Author(s)
  福島耕治, 小原範之, 上野義之
- Organizer
  ESPEN
- Place of Presentation
  オーストリア・ウイーン
- Year and Date
  2009-09-02
- Data Source
  KAKENHI-PROJECT-20590755
[Presentation] トランス脂肪酸と肝関連指標に関する検討2009
- Author(s)
  福島耕治、小原範之、上野義之
- Organizer
  日本静脈経腸栄養学会
- Place of Presentation
  鹿児島
- Year and Date
  2009-01-29
- Data Source
  KAKENHI-PROJECT-20590755
[Presentation] Fatty liver disease model caused by long-term feeding of trans-fatty acids2009
- Author(s)
  福島耕治, 小原範之, 上野義之
- Organizer
  欧州経腸栄養学会
- Place of Presentation
  ウイーン(オーストリア)
- Year and Date
  2009-09-01
- Data Source
  KAKENHI-PROJECT-20590755
[Presentation] Mouse model of nonalcoholic fatty liver disease induced by long term feeding of trans-fat rich high-fat diet2009
- Author(s)
  小原範之, 福島耕治, 上野義之
- Organizer
  欧州肝臓学会
- Place of Presentation
  ボローニャ(イタリア)
- Year and Date
  2009-09-26
- Data Source
  KAKENHI-PROJECT-20590755
[Presentation] Trans fatty acid containing high fat diet induced nonalcoholic fatty liver disease in mice2009
- Author(s)
  小原範之, 福島耕治, 上野義之
- Organizer
  米国肝臓学会
- Place of Presentation
  ボストン(アメリカ)
- Year and Date
  2009-11-02
- Data Source
  KAKENHI-PROJECT-20590755
[Presentation] Mouse model of nonalcoholic fatty liver disease induced by long term feeding of trans-fat rich high-fat diet2009
- Author(s)
  小原範之, 福島耕治, 上野義之
- Organizer
  EASL
- Place of Presentation
  イタリア・ボローニャ
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-20590755
[Presentation] Trans fatty acid containing high fat diet induced nonalcoholic fatty liver disease in mice2009
- Author(s)
  小原範之, 福島耕治, 上野義之
- Organizer
  AASLD
- Place of Presentation
  アメリカ・ボストン
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20590755
[Presentation] Compensatory role of inducible annexin A2 for impaired biliary epithelial anion exchange activity of inflammatory cholangiopathy2008
- Author(s)
  Kido O, Fukushima K, Ueno Y, Inoue J, Jefferson DM, Shimosegawa T
- Organizer
  DDW San Diego
- Year and Date
  2008-05-14
- Data Source
  KAKENHI-PROJECT-19590744
[Presentation] Non alcoholic steatohepatitis(NASH)で認められる高脂肪酸血症の病態への意義2008
- Author(s)
  小原範之、福島耕治、上野義之
- Organizer
  日本肝臓学会
- Place of Presentation
  松山
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-20590755
[Presentation] Compensatory role of inducible annexin A2 for impaired biliary epithelial anion exchange activity of inflammatory cholangiopathy2008
- Author(s)
  Kido O, Fukushima K, Ueno Y, Inoue J, Jefferson DM
- Organizer
  Journal of Hepatology2008
- Place of Presentation
  EASL, Milan, Italy(48 : S173-S173)
- Year and Date
  2008-04-17
- Data Source
  KAKENHI-PROJECT-19590744
[Presentation] An Imbalance in Plasma Amino Acids of Advanced Cirrhotic Patients Influences the Intracellular Amino Acids of Peripheral Blood Mononuclear Cells, and the Imbalance Suppresses the Maturation of Dendritic Cells Via Mtor/S6k Signaling Pathway2008
- Author(s)
  Kokazu E, Ueno Y, Kondo Y, Fukushima K, Shiina M, Yamagiwa Y, Kogure T, Inoue J, Tamai K, Shimosegawa T
- Organizer
  AASLD SanFrancisco
- Place of Presentation
  U.S.A
- Year and Date
  2008-11-02
- Data Source
  KAKENHI-PROJECT-19590744

1. UENO Yoshiyuki (70282126)

# of Collaborated Projects: 5 results

# of Collaborated Products: 30 results
2. KOGURE Takayuki (70400330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 菅野記豊 (70375004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NORIYUKI Obara

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results

FUKUSHIMA Koji 福島 耕治

Research Projects

Research Products

Co-Researchers

肝脂肪蓄積と炎症および細胞ストレスPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of endogenous retroviral genes at human cholestatic liver diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of fatty acids and Kupffer cells for development of liver diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cell biological analysis for studying the target-specific mechanism involved in immune-mediated cholangitis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Extracellular Branched-chain Amino Acids, Especially Valine, Regulate Maturation and Function of Monocyte-derived Dendritic Cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Pathophysiology of the intrahepatic biliary epithelium2008

Author(s)

Publisher

Data Source

[Journal Article] Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice.2010

Author(s)

Journal Title

Data Source

[Journal Article] Possible involvement and the mech anisms of excess trans-fatty acid consumptio n in severe NAFLD in mice.2010

Author(s)

Journal Title

Data Source

[Journal Article] Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice2010

Author(s)

Journal Title

Data Source

[Journal Article] Treatment of Primary Biliary Cirrhosis : A new challenge?2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Treatment of Primary Biliary Cirrhosis : A new challenge?2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Compensatory role of inducible annexin A2 for impaired biliary epithelial anion-exchange activity of inflammatory cholangiopathy2009

Author(s)

Journal Title

Data Source

[Journal Article] Compensatory role of inducible annexin A2 for impaired biliary epithelial anion-exchange activity of inflammatory cholangiopathy.2009

Author(s)

Journal Title

Data Source

[Journal Article] クッパー細胞に対する遊離脂肪酸の生理学的作用2008

Author(s)

Journal Title

Data Source

[Journal Article] クッパー細胞に対する遊離脂肪酸の生理学的作用2008

Author(s)

Journal Title

Data Source

[Journal Article] Amniotic epithelial cell-derived cholangiocytes in experimental cholestatic ductal hyperplasia2007

Author(s)

Journal Title

NAID

FUKUSHIMA Koji 福島耕治