Miyagi Satoru 宮城聡

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MIYAGI Satoru 宮城聡

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Researcher Number	20400997
Other IDs
Affiliation (Current)	2025: 島根大学, 学術研究院医学・看護学系, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 島根大学, 学術研究院医学・看護学系, 教授 2018 – 2021: 島根大学, 学術研究院医学・看護学系, 准教授 2016 – 2017: 千葉大学, 大学院医学研究院, 特任講師 2009 – 2012: Chiba University, 大学院・医学研究院, 助教 2011: 千葉大学, 医学(系)研究科(研究院), 助教 … More 2008: 千葉大学, 大学院医学研究院, 助教 2007: Chiba University, 大学院・医学研究院, 助教 2006: 千葉大学, 大学院医学研究院, 助手 Less
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related / General medical chemistry Except Principal Investigator Gastroenterology / Hematology / Biological Sciences
Keywords	Principal Investigator 造血幹細胞 / 遺伝子発現制御 / クロマチン / 白血病 / クロマチンタンパク質 / 転写制御 / 自己複製 / エピジェネティクス / リン酸化 / ユビキチン化 … More / 細胞系譜追跡 / ニッチ / 造血支持細胞 / FZD5 / 間葉系幹細胞 / 急性リンパ性白血病 / メチル化 / METTL18 / RNAiスクリーニング / T-ALL / 創薬標的 / shRNA スクリーン / T細胞性急性リンパ性白血病 / 胸腺細胞分化 / T細胞分化 / 核構造 / 細胞分化 / 幹細胞 / 神経幹細胞 / Sox2 … More Except Principal Investigator ポリコーム群遺伝子 / 自己複製能 / 肝臓癌 / 癌幹細胞 / Bmi1 / Bmil / 自己複製 / DZNep / EZH2 / BMI1 / Arf / Ink4a / bivalent domain / Fus / ヒストン脱メチル化酵素 / 白血病幹細胞 / 造血幹細胞 / ポリコーム複合体 / SP細胞 / フローサイトメトリー / CD90 / CD133 / CD133, CD90 / Ring1b / 精子幹細胞 / ポリコーム遺伝子 Less

PHF6の翻訳後修飾を介した造血幹細胞制御Principal Investigator
- Principal Investigator
  
  宮城聡
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Shimane University
Identification of mesenchymal stem cell, which gives rise to hematopoiesis supporting cellsPrincipal Investigator
- Principal Investigator
  
  Miyagi Satoru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Shimane University
Pooled shRNA screening for novel potential drug targets in T-ALLPrincipal Investigator
- Principal Investigator
  
  Miyagi Satoru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Shimane University
  Chiba University
Role of histone acetyltransferase, Hbo1, in hematopoiesisPrincipal Investigator
- Principal Investigator
  
  MIYAGI Satoru
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
Regulation of hematopoietic and leukemic stem cells by the polycomb complexes
- Principal Investigator
  
  IWAMA Atsushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
Investigation of novel target genes regulated by polycomb group genes in hepatocellular carcinoma
- Principal Investigator
  
  CHIBA Tetsuhiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Role of transcriptional co-repressor, TIF1b, in hematopoietic stem cellPrincipal Investigator
- Principal Investigator
  
  MIYAGI Satoru
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
Investigation of cancer stem cell system in hepatocellular carcinoma
- Principal Investigator
  
  CHIBA Tetsuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
生殖系幹細胞の自己複製制御機構の解明
- Principal Investigator
  
  IWAMA Atsushi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
幹細胞の自己複製におけるSox2遺伝子の機能Principal Investigator
- Principal Investigator
  
  宮城聡
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Chiba University

[Journal Article] Generation of a BAC transgenic mouse strain that expresses CreERT and a fluorescent protein under the transcriptional control of the Fzd5 locus2022
- Author(s)
  Miyagi Satoru、Kato Yuko、Watanabe Ayako、Miyamoto Kenichi、Yoshikawa Rintaro、Hagiya Keita、Hirano Daisuke、Matsuzaki Yumi
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 42 Issue: 1
- DOI
  10.1186/s41232-022-00194-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08865, KAKENHI-PROJECT-22K08454, KAKENHI-PROJECT-22K08477
[Journal Article] Plant homeodomain finger protein 6 in the regulation of normal and malignant hematopoiesis.2020
- Author(s)
  Miyagi S, Iwama A.
- Journal Title
  
  Curr Opin Hematol.
  
  Volume: - Issue: 4 Pages: 248-253
- DOI
  10.1097/moh.0000000000000588
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-19K08865
[Journal Article] Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche2019
- Author(s)
  Kato Yuko、Hou Li-Bo、Miyagi Satoru、Nitta Eriko、Aoyama Kazumasa、Shinoda Daisuke、Yamazaki Satoshi、Kuribayashi Wakako、Isshiki Yusuke、Koide Shuhei、Si Sha、Saraya Atsunori、Matsuzaki Yumi、van Lohuizen Maarten、Iwama Atsushi
- Journal Title
  
  Experimental Hematology
  
  Volume: 76 Pages: 24-37
- DOI
  10.1016/j.exphem.2019.07.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08865, KAKENHI-PUBLICLY-18H05095, KAKENHI-WRAPUP-19H05442, KAKENHI-PROJECT-17H05086, KAKENHI-PROJECT-17K09900, KAKENHI-PROJECT-18K19555
[Journal Article] The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells.2019
- Author(s)
  Miyagi S, Sroczynska P, Kato Y, Nakajima-Takagi Y, Oshima M, Rizq O, Takayama N, Saraya A, Mizuno S, Sugiyama F, Takahashi S, Matsuzaki Y, Christensen J, Helin K, and Iwama A.
- Journal Title
  
  Blood
  
  Volume: - Issue: 23 Pages: 2495-2506
- DOI
  10.1182/blood.2019000468
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-16K09840, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-19K08865, KAKENHI-WRAPUP-19H05442, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-18K19555
[Journal Article] Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells2019
- Author(s)
  Kanayama K, Chiba T, Oshima Kanzaki H, Koide S, Saraya A, Miyagi S, Mimura N, Kusakabe Y, Saito T, Ogasawara S, Suzuki E, Ooka Yoshihiko, Maruyama H, Iwama A, Kato N.
- Journal Title
  
  Stem Cells Int
  
  Volume: 2019 Pages: 9789240-9789240
- DOI
  10.1155/2019/9789240
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09340, KAKENHI-PROJECT-19K08865
[Journal Article] Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome.2018
- Author(s)
  Tara S, Isshiki Y, Nakajima-Takagi Y, Oshima M, Aoyama K, Tanaka T, Shinoda D, Koide S, Saraya A, Miyagi S, Manabe I, Matsui H, Koseki H, Bardwell VJ, Iwama A.
- Journal Title
  
  Blood
  
  Volume: 132(23) Issue: 23 Pages: 2470-2483
- DOI
  10.1182/blood-2018-01-827964
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08348, KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-16K09840, KAKENHI-INTERNATIONAL-15K21751
[Journal Article] Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma2017
- Author(s)
  Yokoyama M, Chiba T, Zen Y, Oshima M, Kusakabe Y, Noguchi Y, Yuki K, Koide S, Tara S, Saraya A, Aoyama K, Mimura N, Miyagi S, et al.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 13 Pages: 21315-21326
- DOI
  10.18632/oncotarget.15528
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09340, KAKENHI-PROJECT-16K09840
[Journal Article] Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.2016
- Author(s)
  Agger, K., Miyagi, S., Pedersen, M.T., Kooistra, S.M., Johansen, J.V., and Helin, K.
- Journal Title
  
  Genes Dev
  
  Volume: 30 Issue: 11 Pages: 1278-1288
- DOI
  10.1101/gad.280495.116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09840
[Journal Article] Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells.2016
- Author(s)
  Oshima M, Hasegawa N, Mochizuki-Kashio M, Muto T, Miyagi S, Koide S, Yabata S, Wendt G, Saraya A, Wang C, Shimoda K, Suzuki Y, Iwama A.
- Journal Title
  
  Exp Hematol
  
  Volume: 44(4) Issue: 4 Pages: 282-296
- DOI
  10.1016/j.exphem.2015.12.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0002, KAKENHI-PROJECT-14J40024, KAKENHI-PROJECT-16K09840
[Journal Article] Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of non-hematopoietic genes.2016
- Author(s)
  Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y,Iwama A.
- Journal Title
  
  Blood
  
  Volume: 128(5) Issue: 5 Pages: 638-649
- DOI
  10.1182/blood-2016-01-694810
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01513, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-15J04258, KAKENHI-PROJECT-26293228, KAKENHI-PROJECT-15K09478, KAKENHI-PROJECT-16K09340, KAKENHI-PROJECT-16K09840, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] Role of SOX17 in hematopoietic development from human embryonic stem cells2013
- Author(s)
  Nakajima-Takagi, Y., Osawa, M., Oshima, M., Takagi, H., Miyagi, S., Endoh, M., Endo, T.A., Takayama, N., Eto, K., Toyoda, T., Koseki, H., Nakauchi, H. and Iwama, A
- Journal Title
  
  Blood
  
  Volume: 121 Pages: 447-458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791071
[Journal Article] Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia2012
- Author(s)
  Tanaka, S., Miyagi, S., Sashida, G., Chiba, T., Yuan, J., Mochizuki-Kashio, M., Suzuki, Y., Sugano, S., Nakaseko, C., Yoko te, K., Koseki, H. and Iwama, A
- Journal Title
  
  Blood
  
  Volume: 120 Pages: 1107-1117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791071
[Journal Article] 3-Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells2012
- Author(s)
  Chiba T, Suzuki E, Negishi M, Saraya A, Miyagi S, Konuma T, Tanaka S, Tada M, Kanai F, Imazeki F, Iwama A, Yokosuka O
- Journal Title
  
  International Journal of Cancer
  
  Volume: 130(11) Issue: 11 Pages: 2557-2567
- DOI
  10.1002/ijc.26264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03550, KAKENHI-PROJECT-21390289, KAKENHI-PUBLICLY-23130502, KAKENHI-PROJECT-23689039, KAKENHI-PROJECT-23791071
[Journal Article] Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes2012
- Author(s)
  Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H, Nakauchi H, Iwama A
- Journal Title
  
  J Exp Med
  
  Volume: 209 Pages: 445-454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390289
[Journal Article] Emx2 is a dose-dependent negative regulator of Sox2 telencephalic enhancers.2012
- Author(s)
  Mariani J, Favaro R, Lancini C, Vaccari G, Ferri ALM, Bertolini J, Tonoli D, Latorre E, Caccia R, Ronchi A, Ottolenghi S, Miyagi S, Okuda A, Zappavigna V, Nicolis SK.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 40 Issue: 14 Pages: 6461-6476
- DOI
  10.1093/nar/gks295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590275, KAKENHI-PROJECT-23791071
[Journal Article] Lethal myelofibrosis induced by Bmil-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes2012
- Author(s)
  Oguro H
- Journal Title
  
  J Exp Med
  
  Volume: 209 Issue: 3 Pages: 445-454
- DOI
  10.1084/jem.20111709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390289, KAKENHI-PUBLICLY-23130502, KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23791071
[Journal Article] Bmil confers resistance to oxidative stress on hematopoietic stem cells.2012
- Author(s)
  Nakamura S, Oshima M, Yuan J, Saray a A, Miyagi S, Konuma T, Yamazaki S, Osawa M, Nakauchi H, Koseki H, Iwama A.
- Journal Title
  
  PLoS One
  
  Volume: 7(5) Issue: 5 Pages: e36209-e36209
- DOI
  10.1371/journal.pone.0036209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03550, KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23791071, KAKENHI-PROJECT-24249056, KAKENHI-PLANNED-23106004
[Journal Article] Aldehyde dehydrogenase 1 is associated with recurrence-free survival but not stem cell-like properties in hepatocellular carcinoma2012
- Author(s)
  Suzuki, E., Chiba, T., Zen, Y., Miyagi, S., Tada, M., Kanai, F., Imazeki, F., Miyazaki, M., Iwama, A. and Yokosuka, O
- Journal Title
  
  Hepatol Res
  
  Volume: 42 Pages: 1100-1111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791071
[Journal Article] Direct activation of STAT5 by ETV6-Lyn fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis2011
- Author(s)
  Takeda Y, Nakaseko C, Tanaka H, Takeuchi M, Yui M, Saraya A, Miyagi S, Wang C, Tanaka S, Ohwada C, Sakaida E, Yamaguchi N, Yokote K, Hennighausen L, Iwama A
- Journal Title
  
  Br J Haematol
  
  Volume: 153 Pages: 589-598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390289
[Journal Article] The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis2011
- Author(s)
  Mishima Y
- Journal Title
  
  Blood
  
  Volume: 118 Issue: 9 Pages: 2443-2453
- DOI
  10.1182/blood-2011-01-331892
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22116513, KAKENHI-PUBLICLY-23130502, KAKENHI-PROJECT-23791071, KAKENHI-PROJECT-23791094
[Journal Article] Dependency on the polycomb protein Ezh2 distinguishes fetal from adult hematopoietic stem cells2011
- Author(s)
  Mochizuki-Kashio M, Mishima Y, Miyagi S, Negishi M, Saraya A, Konuma T, Shinga J, Koseki H, Iwama A
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 6553-6561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390289
[Journal Article] The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis2011
- Author(s)
  Mishima Y, Miyagi S, Saraya A, Negishi M, Endoh M, Endo TA, Toyoda T, Shinga J, Katsumoto T, Chiba T, Yamaguchi N, Kitabayashi I, Koseki H, Iwama A
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 2443-2453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390289
[Journal Article] Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells2011
- Author(s)
  Konuma T, et al
- Journal Title
  
  Experimental Hematology
  
  Volume: 39(6) Issue: 6 Pages: 697-709
- DOI
  10.1016/j.exphem.2011.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03550, KAKENHI-PROJECT-21390289, KAKENHI-PUBLICLY-23130502, KAKENHI-PROJECT-23791071
[Journal Article] Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis.2011
- Author(s)
  Takeda, Y., Nakaseko, C., Tanaka, H., Takeuchi, M., Yui, M., Saraya, A., Miyagi, S., Wang, C., Tanaka, S., Ohwada, C., Sakaida, E., Yamaguchi, N., Yokote, K., Hennighausen, L., Iwama A.
- Journal Title
  
  Br.J.Haematol. 153
  
  Pages: 589-598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790906
[Journal Article] Direct activation of Stat5 by ETV6-Lyn fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis2011
- Author(s)
  Takeda, et al.
- Journal Title
  
  British Journal of Haematology
  
  Volume: 153 Issue: 5 Pages: 2874-2903
- DOI
  10.1111/j.1365-2141.2011.08663.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390017, KAKENHI-PUBLICLY-23130502, KAKENHI-PROJECT-23390185, KAKENHI-PROJECT-23791071
[Journal Article] Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells2011
- Author(s)
  Mochizuki-Kashio M, Mishima Y, Miyagi S, Negishi M, Saraya A, Konuma T, Shinga J, Koseki H, Iwama A
- Journal Title
  
  Blood
  
  Volume: 118(25) Issue: 25 Pages: 6553-6561
- DOI
  10.1182/blood-2011-03-340554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03550, KAKENHI-PUBLICLY-23130502, KAKENHI-PROJECT-23791071
[Journal Article] Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells2011
- Author(s)
  Konuma T, Nakamura S, Miyagi S, Negishi M, Chiba T, Oguro H, Yuan J, Mochizuki-Kashio M, Ichikawa H, Miyoshi H, Vidal M Iwama A
- Journal Title
  
  Exp Hematol
  
  Volume: 39 Pages: 697-709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390289
[Journal Article] Bmil promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.2010
- Author(s)
  Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.
- Journal Title
  
  Hepatology 52
  
  Pages: 1111-1123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790649
[Journal Article] The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.2010
- Author(s)
  Chiba T, Aoki R, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A.
- Journal Title
  
  J Hepatol 52
  
  Pages: 854-863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790649
[Journal Article] The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.2010
- Author(s)
  Aoki, R., Chiba, T., Miyagi, S., Negishi, M., Konuma, T., Taniguchi, H., Ogawa, M., Yokosuka, O., Iwama, A.
- Journal Title
  
  J Hepatol. 52
  
  Pages: 854-863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790906
[Journal Article] The polycomb-group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells2010
- Author(s)
  Aoki R, Chiba T, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A
- Journal Title
  
  J Hepatology
  
  Volume: 52 Pages: 854-863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390289
[Journal Article] Identification of a novel TEL-Lyn fusion gene in primary myelofibrosis2010
- Author(s)
  Tanaka H, Takeuchi M, Takeda Y, Sakai S, Oda K, Abe D, Ohwada C, Ozawa S, Sakaida E, Shimizu N, Saito Y, Miyagi S, Iwama A, Nakaseko C
- Journal Title
  
  Leukemia
  
  Volume: 24 Pages: 297-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390289
[Journal Article] The polycomb-group gene Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and independent manners2010
- Author(s)
  Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A
- Journal Title
  
  Hepatology
  
  Volume: 52 Pages: 1111-1123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390289
[Journal Article] Identification of a novel TEL-Lyn fusion gene in primary myelofibrosis.2010
- Author(s)
  Tanaka, H., Takeuchi, M., Takeda, Y., Sakai, S., Abe, D., Ohwada, C., Sakaida, E., Shimizu, N., Saito, Y., Miyagi, S., Iwama, A., Nakaseko, C.
- Journal Title
  
  Leukemia 24
  
  Pages: 197-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790906
[Journal Article] The polycomb-group gene Bmil promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and independent manners.2010
- Author(s)
  Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.
- Journal Title
  
  Hepatology. 52
  
  Pages: 1111-1123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790906
[Journal Article] Dmapl plays an essential role in the maintenance of genome integrity through the DNA repair process.2009
- Author(s)
  Negishi, M., Chiba, T., Saraya, A., Miyagi, S., Iwama, A.
- Journal Title
  
  Genes Cells 14
  
  Pages: 1347-1357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790906
[Journal Article] Role of SoxB1 transcription factors in development2009
- Author(s)
  Miyagi, S., et al.
- Journal Title
  
  Cellular and Molecular Lifescience 66
  
  Pages: 3675-3684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790906
[Journal Article] DMAP1 is essential for the recruitment of Pcna to repair foci2009
- Author(s)
  Negishi M, Chiba T, Saraya A, Miyagi S, Iwama A
- Journal Title
  
  Genes Cells
  
  Volume: 14 Pages: 1347-1357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390289
[Journal Article] Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma.2009
- Author(s)
  Yonemitsu, Y., Imazeki, F., Chiba, T., Fukai, K., Nagai, Y., Miyagi, S., Arai, M., Aoki, R., Miyazaki, M., Nakatani, Y., Iwama, A., Yokosuka, O.
- Journal Title
  
  Hum.Pathol. 40
  
  Pages: 1304-1311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790906
[Journal Article] Dmapl plays an essential role in the maintenance of genome integrity through the DNA repair process.2009
- Author(s)
  Negishi M, Chiba T, Saraya A, Miyagi S, Iwama A.
- Journal Title
  
  Gene Cells, 14
  
  Pages: 1347-1357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790649
[Journal Article] Role of SoxB1 transcription factors in development.2009
- Author(s)
  Miyagi, S., Kato, H., Okuda, A.
- Journal Title
  
  Cell Mol Life Sci. 66
  
  Pages: 3675-3684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790906
[Journal Article] Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma2009
- Author(s)
  Yonemitsu Y, Imazeki F, Chiba T, Fukai K, Nagai Y, Miyagi S, Arai M, Aoki R, Miyazaki M, Nakatani Y, Iwama A, Yokosuka O
- Journal Title
  
  Hum Pathology
  
  Volume: 40 Pages: 1304-1311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390289
[Journal Article] The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma.2008
- Author(s)
  Chiba T, Miyagi S, Saraya A, Ryutaro Aoki R, Seki A, Morita Y, Yonemitsu Y, Yokosuka O, Taniguchi H, Nakauchi H,Iwama A.
- Journal Title
  
  Cancer Res 68
  
  Pages: 7742-7749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790468
[Journal Article] The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon.2006
- Author(s)
  Miyagi, S.
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 13374-13381
- Data Source
  KAKENHI-PROJECT-18790192
[Journal Article] 3-deazaneplanocin is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells
- Author(s)
  Chiba T, Suzuki E, Negishi M, Saraya A, Miyagi S, Konuma T, Tanaka S, Tada M, Kanai F, Imazeki F, Iwama A, Yokosuka O
- Journal Title
  
  Int J Cancer
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390289
[Journal Article] Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells.
- Author(s)
  Konuma, T., Nakamura, S., Miyagi, S., Negishi, M., Chiba, T., Oguro, H., Yuan, J., Mochizuki-Kashio, M., Ichikawa, H., Miyoshi, H., Vidal, M., Iwama, A.
- Journal Title
  
  Exp.Hematol. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790906
[Journal Article] Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma.
- Author(s)
  Yonemitsu Y, Imazeki F, Chiba T, Fukai K, Nagai Y, Miyagi S, Arai M, Aoki R, Miyazaki M, Nakatani Y, Iwama A, Yokosuka O.
- Journal Title
  
  Hum Pathol (in press.)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] Phip deficiency leads to the expansion of hematopoietic stem/progenitor cells and splenomegaly upon aging.2023
- Author(s)
  Yuko Kato1, Takako Yokomizo2, Goro Sashida3, and Atsushi Iwama2, Satoru Miyagi4
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-22K08454
[Presentation] 造血幹細胞制御因子Phf6の結合因子の同定とその機能解析2020
- Author(s)
  宮城聡、加藤裕子、岩間厚志、松崎有未
- Organizer
  炎症再生医学会
- Data Source
  KAKENHI-PROJECT-19K08865
[Presentation] BRD1はHBO1、ING4とヒストンアセチル化酵素複合体を形成しヒストンH3のアセチル化に働く2010
- Author(s)
  宮城聡
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21790906
[Presentation] Brdl/Brpf2 is a core component of the Hbo1 HAT complex and regulates fetal liver erythropoiesis2010
- Author(s)
  Satoru Miyagi
- Organizer
  The 1st JSH International Symposium
- Place of Presentation
  Akita University
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-21790906
[Presentation] Brd1/Brpf2 is a core component of the Hbo1 HAT complex and regulates fetal liver erythropoiesis2010
- Author(s)
  Satoru Miyagi
- Organizer
  The 1st JSH International Symposium
- Place of Presentation
  Akita University
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-21790906
[Presentation] 転写共役因子TIF1βは造血幹細胞の維持に働く2009
- Author(s)
  宮城聡
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21790906
[Presentation] 転写共役因子TIF1 β は造血幹細胞の維持に働く2009
- Author(s)
  宮城聡
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21790906
[Presentation] Brd1(Bromodomain-containing protein 1)-Hbo1複合体による赤血球分化制御2009
- Author(s)
  宮城聡
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21790906
[Presentation] Brdl (Bromodomain-containing protein 1)-Hbol複合体による赤血球分化制御2009
- Author(s)
  宮城聡
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21790906
[Presentation] Molecular machinery in the establishment and maintenance of liver cancer stem cell system.2008
- Author(s)
  千葉哲博、宮城聡、横須賀收、岩間厚志
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  愛知県
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] The polycomb gene product BMI1 is required for the tumor-initiating capacity of hepatocellular carcinoma cells.2007
- Author(s)
  千葉哲博、宮城聡、横須賀收、岩間厚志
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  神奈川県
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] Investigation of cancer stem cell system in hepatocellular carcinoma.2007
- Author(s)
  Chiba T, Miyagi S, Yokosuka O, Taniguchi H, Nakauchi H, Iwama A.
- Organizer
  17th APASL conference
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-19790468

1. IWAMA Atsushi (70244126)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
2. YOKOSUKA Osamu (90182691)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. CHIBA Tetsuhiro (00381583)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
4. OGURO Hideyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. MOCHIZUKI Makiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. OHSHIMA Motohiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. KATO NAOYA

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 奥田晶彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 武藤香織

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 鈴木穣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 松井啓隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyagi Satoru 宮城 聡

MIYAGI Satoru 宮城 聡

Research Projects

Research Products

Co-Researchers

PHF6の翻訳後修飾を介した造血幹細胞制御Principal Investigator

Principal Investigator

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Research Institution

Identification of mesenchymal stem cell, which gives rise to hematopoiesis supporting cellsPrincipal Investigator

Principal Investigator

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Review Section

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Pooled shRNA screening for novel potential drug targets in T-ALLPrincipal Investigator

Principal Investigator

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Research Institution

Role of histone acetyltransferase, Hbo1, in hematopoiesisPrincipal Investigator

Principal Investigator

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Research Institution

Regulation of hematopoietic and leukemic stem cells by the polycomb complexes

Principal Investigator

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Investigation of novel target genes regulated by polycomb group genes in hepatocellular carcinoma

Principal Investigator

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Research Institution

Role of transcriptional co-repressor, TIF1b, in hematopoietic stem cellPrincipal Investigator

Principal Investigator

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Research Institution

Investigation of cancer stem cell system in hepatocellular carcinoma

Principal Investigator

Project Period (FY)

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Research Institution

生殖系幹細胞の自己複製制御機構の解明

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

幹細胞の自己複製におけるSox2遺伝子の機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

[Journal Article] Generation of a BAC transgenic mouse strain that expresses CreERT and a fluorescent protein under the transcriptional control of the Fzd5 locus2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plant homeodomain finger protein 6 in the regulation of normal and malignant hematopoiesis.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche2019

Author(s)

Journal Title

DOI

Data Source

Miyagi Satoru 宮城聡

MIYAGI Satoru 宮城聡