KASHIWAYAMA Yoshinori 柏山恭範

Researcher Number	20401812
Affiliation (based on the past Project Information) *help	2013: 富山大学, 大学院医学薬学研究部(薬学), 助教 2011: University of Toyama, 助教 2010: 富山大学, 大学院・医学薬学研究部(薬学), 助教 2007 – 2010: University of Toyama, 大学院・医学薬学研究部, 助教 2006: 富山大学, 大学院医学薬学研究部, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator ペルオキシソーム / 細胞内小器官 / タンパク質輸送 / タンパク質局在化 / オルガネラ形成 / ABCタンパク質 Except Principal Investigator ペルオキシソーム / 原虫治療薬 / タンパク質局在化 / トリパノソーマ感染治療薬 … More / ハイスループットスクリーニング / トリパノソーマ感染症治療薬 / 膜タンパク質局在化 / ペルオキシソーム膜形成 / グリコソーム / ATP結合・加水分解 / 結晶化 / 基質輪送機 / Pex19P / X線結晶構造解析 / Pex3p / Pex19p / 脂肪酸輸送 / 基質輸送機構 / 局在化機構 / 小胞体 / ABCタンパク質 Less

Analysis of peroxisome membrane biogenesis and application for Nano-medicine
- Principal Investigator
  
  IMANAKA Tsuneo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Toyama
ペルオキシソーム膜上に存在する新規膜タンパク質挿入装置の同定と機能解析Principal Investigator
- Principal Investigator
  
  柏山恭範
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Toyama
Organelle selective targeting of ABC subfamily D proteins and molecular mechanisms of their functions on the membranes
- Principal Investigator
  
  IMANAKA Tsuneo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Toyama
ペルオキシソーム膜ABCタンパク質のペルオキシソーム膜選択的局在化機構の解析Principal Investigator
- Principal Investigator
  
  柏山恭範
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Toyama

All 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] ABC subfamily D proteins and very long chain fatty acid metabolism as novel targets in adrenoleukodystrophy.2011
- Author(s)
  Morita M., Shimozawa N., Kashiwayama Y., Suzuki Y., and Imanaka T.
- Journal Title
  
  Curr. Drug Targets
  
  Volume: 12 Pages: 694-706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590072
[Journal Article] ABC subfamily D proteins and very long chain fatty acid metabolism as novel targets in adrenoleukodystrophy2011
- Author(s)
  Morita M., Shimozawa, N., Kashiwayama Y., Suzuki Y. and Imanaka T
- Journal Title
  
  Curr. Drug Targets
  
  Volume: 12 Pages: 694-706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590072
[Journal Article] Identification of a substrate-binding site in a peroxisomal β-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative.2010
- Author(s)
  Kashiwayama Y., Tomohiro T., Narita K., Suzumura M., Glumoff T., Hiltunen J.K., Van Veldhoven P.P., Hatanaka Y., Imanaka T.
- Journal Title
  
  J.Biol.Chem. 285
  
  Pages: 26315-26325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590054
[Journal Article] Multiple organelle-targeting signals in the N-terminal portion of peroxisomal membrane protein PMP70.2010
- Author(s)
  Iwashita S., Tsuchida M., Tsukuda M., Yamashita Y., Emi Y., Kida Y., Komori M., Kashiwayama Y., Imanaka T., Sakaguchi M.
- Journal Title
  
  J.Biochem. 147
  
  Pages: 581-590
- NAID
  10027875314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590054
[Journal Article] Identification of a substrate-binding site in a peroxisomal n-oxidation enzyme by photoaffinity labeling with a novel palmitovl derivative.2010
- Author(s)
  Kashiwayama Y., et al.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Pages: 26315-26325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590054
[Journal Article] Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p.2010
- Author(s)
  Sato Y., Shibata H., Nakatsu T., Nakano H., Kashiwayama Y., Imanaka T., Kato H.
- Journal Title
  
  EMBO J. 29
  
  Pages: 4083-4093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590054
[Journal Article] Identification of a substrate-binding site in a peroxisomal β-oxidationenzyme by photoaffinity labeling with a novel palmitoyl derivative.2010
- Author(s)
  Kashiwayama Y., et al.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 285 Pages: 26315-26325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790064
[Journal Article] 70-kDa peroxisomal membrane protein related protein(P70R/ABCD4)localizes to endoplasmic reticulum not peroxisomes, and NH_2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins.2009
- Author(s)
  Kashiwayama Y., Seki M., Yasui A., Murasaki Y., Morita M., Sakaguchi M., Tanaka Y., Imanaka T.
- Journal Title
  
  Exp.Cell Res. 315
  
  Pages: 190-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590054
[Journal Article] Characterization of the interaction between recombinant human peroxin Pex3p and Pex19p : Identification of TRP104 in Pex3p as a critical residue for the interaction.2008
- Author(s)
  Sato Y., Shibata H., Nakano H., Matsuzono Y., Kashiwayama Y., Kobayashi Y., Fujiki Y., Imanaka T., Kato H.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 61346-61446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590054
[Journal Article] 70-kDa peroxisomal membrane protein related protein (p70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH_2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins.2008
- Author(s)
  Kashiwayama, Y.
- Journal Title
  
  Exp. Cell Res 315
  
  Pages: 190-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590054
[Journal Article] Hydrophobic regions adjacent to transmembrane domain 1 and 5 are important for the targeting of the 70-kDa peroxisomal membrane protein.2007
- Author(s)
  Kashiwayama Y., et. al.
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages: 33831-33944
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790050
[Presentation] A new therapeutic approach for trypanosome protozoa: Screening of chemical compounds that inhibit biogenesis of glycosome.2013
- Author(s)
  Watanabe Y, Okuyama N, Kawaguchi K, Morita M, Kashiwayama Y, Imanaka T.
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590072
[Presentation] グリコソーム形成因子をターゲットとした新規抗トリパノソーマ薬の開発．2013
- Author(s)
  渡邊雄一，奥山尚輝，川口甲介，守田雅志, 柏山恭範，今中常雄
- Organizer
  日本生化学会北陸支部第31回大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590072
[Presentation] A new therapeutic approach for trypanosome protozoa : Screening of chemical compounds that inhibit biogenesis of glycosome2013
- Author(s)
  Watanabe Y., Okuyama N., Kawaguchi K., Morita M., Kashiwayama Y., and Imanaka T
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590072
[Presentation] グリコソーム形成因子をターゲットとした原虫感染症治療薬開発のためのスクリーニング系の構築．2012
- Author(s)
  渡邉雄一，奥山尚輝，楠本梨賀，川口甲介，守田雅志，柏山恭範，今中常雄
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590072
[Presentation] グリコソーム形成因子をターゲットとした原虫感染症治療薬開発のためのスクリーニング系の構築2012
- Author(s)
  渡邉雄一,奥山尚輝,楠本梨賀,川口甲介,守田雅志,柏山恭範,今中常雄
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590072
[Presentation] ABCタンパク質サブファミリーDの細胞内局在化機構―ヒト，線虫及び粘菌での共通性―2011
- Author(s)
  李朝香，朝日彰子，赤池宗輔，柏山恭範，守田雅志，安川洋生，今中常雄
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590072
[Presentation] ABC タンパク質サブファミリーD の細胞内局在化におけるN末端疎水性アミノ酸配列の役割．2011
- Author(s)
  李朝香，朝日彰子，赤池宗輔，柏山恭範，守田雅志，安川洋生，今中常雄
- Organizer
  日本生化学会北陸支部第29回大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590072
[Presentation] ABCタンパク質サブファミリーDのオルガネラ膜への選別輸送機構：N末端マルチオルガネラ移行シグナルの解析．2011
- Author(s)
  李朝香，朝日彰子，阪口雅郎，柏山恭範，今中常雄
- Organizer
  第10回次世代を担う若手ファーマ・バイオフォーラム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23590072
[Presentation] 小胞体膜上に存在するABCタンパク質P70R (ABCD4) の存在状態の解析．2011
- Author(s)
  上杉泰介，柏山恭範，今中常雄
- Organizer
  日本薬学会北陸支部第123回例会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590072
[Presentation] 小胞体膜上に存在するABCタンパク質P70R(ABCD4)の存在状態の解析.2011
- Author(s)
  上杉泰介，柏山恭範，今中常雄
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590072
[Presentation] Identification of a substrate-binding site in a peroxisomal β-oxidation enzyme by diazirine-based photoaffinity labeling.2011
- Author(s)
  Tomohiro T., Kashiwayama Y, Imanaka T, and Hatanaka Y.
- Organizer
  8th AFMC International Medicinal Chemistry Symposium: Frontier of Medicinal Science
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590072
[Presentation] Complex formation of ABC protein, P70R/ABCD4 on endoplasmic reticulum membranes.2011
- Author(s)
  Uesugi T. , Kashiwayama Y., and Imanaka T.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590072
[Presentation] 小胞体膜上に局在するABCD4 (P70R) の存在様式と機能．2011
- Author(s)
  上杉泰介，赤池宗輔，柏山恭範，守田雅志，加藤博章，今中常雄
- Organizer
  第33回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-23590072
[Presentation] ABCタンパク質サブファミリーD群のオルガネラ選択的局在化機構2010
- Author(s)
  柏山恭範、今中常雄
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山
- Year and Date
  2010-11-29
- Data Source
  KAKENHI-PROJECT-22790064
[Presentation] ABCタンパク質サブファミリーDの細胞内局在化とN末端アミノ酸配列2010
- Author(s)
  李朝香, 朝日彰子, 赤池宗輔, 柏山恭範, 守田雅志, 安川洋生, 今中常雄
- Organizer
  第83回日本生化学会大会・第33回日本分子生物学会年会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590054
[Presentation] ABCタンパク質サブファミリーD群のオルガネラ選択的局在化機構2010
- Author(s)
  柏山恭範, 他
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山
- Year and Date
  2010-11-29
- Data Source
  KAKENHI-PROJECT-20590054
[Presentation] 小胞体膜上に存在するABCタンパク質P70R(ABCD4)の存在状態と機能の解析2010
- Author(s)
  東野和直, 上杉泰介, 柏山恭範, 今中常雄
- Organizer
  第83回日本生化学会大会・第33回日本分子生物学会年会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590054
[Presentation] Identification of a substrate-binding site in a peroxisomal β-oxidation enzyme by photoaffinity labeling with palmitoyl derivative.2009
- Author(s)
  Kashiwayama, Y.
- Organizer
  The 5th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  東京
- Year and Date
  2009-05-25
- Data Source
  KAKENHI-PROJECT-20590054
[Presentation] Importance of the NH_2-terminal hydrophobic motifs on the peroxisome selective targeting of PMP70.2009
- Author(s)
  柏山恭範, 守田雅志, 今中常雄
- Organizer
  International Meeting on Peroxisome Research
- Place of Presentation
  Seattle, USA.
- Year and Date
  2009-11-19
- Data Source
  KAKENHI-PROJECT-20590054
[Presentation] ペルオキシソーム膜タンパク質局在化の分子機構 : PMP70をモデルタンパク質としての解析2009
- Author(s)
  柏山恭範
- Organizer
  日本生化学会北陸支部第27回大会
- Place of Presentation
  福井
- Year and Date
  2009-05-23
- Data Source
  KAKENHI-PROJECT-20590054
[Presentation] ABCD群タンパク質の細胞内局在はN末端アミノ酸配列が制御している2008
- Author(s)
  柏山恭範
- Organizer
  日本生化学会北陸支部第26回大会
- Place of Presentation
  金沢大学
- Year and Date
  2008-05-31
- Data Source
  KAKENHI-PROJECT-20590054
[Presentation] ABCタンパク質D群の細胞内局在はN末端アミノ酸配列に依存する2008
- Author(s)
  柏山恭範, 関みどり, 安井暁奈, 守田雅志, 今中常雄
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2008-08-07
- Data Source
  KAKENHI-PROJECT-20590054
[Presentation] P70R (ABCD4)の細胞内局在と局在化機構の解析から明らかになるABCサブフアミリーD群タンパク質の細胞内局在制御機構2008
- Author(s)
  柏山恭範
- Organizer
  第3回トランスポーター研究会年会
- Place of Presentation
  京都大学
- Year and Date
  2008-06-07
- Data Source
  KAKENHI-PROJECT-20590054
[Presentation] ABCタンパク質D群の細胞内局在はN末端アミノ酸配列に依存する2008
- Author(s)
  柏山恭範
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2008-08-07
- Data Source
  KAKENHI-PROJECT-20590054
[Presentation] ABCタンパク質PMP70ならびにP70Rのオルガネラ局在化機構の解析2007
- Author(s)
  柏山恭範、関みどり、安井暁奈、朝比奈幸太、守田雅志、今中常雄
- Organizer
  第二回トランスポーター研究会
- Place of Presentation
  東京
- Year and Date
  2007-06-10
- Data Source
  KAKENHI-PROJECT-18790050
[Presentation] PMP70のペルオキシソーム局在化シグナルはPex19p結合領域とは異なる領域に存在する2007
- Author(s)
  柏山恭範、守田雅志、今中常雄
- Organizer
  第30回日本分子生物学会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-18790050

1. IMANAKA Tsuneo (50119559)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results

KASHIWAYAMA Yoshinori 柏山 恭範

Research Projects

Research Products

Co-Researchers

Analysis of peroxisome membrane biogenesis and application for Nano-medicine

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ペルオキシソーム膜上に存在する新規膜タンパク質挿入装置の同定と機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Organelle selective targeting of ABC subfamily D proteins and molecular mechanisms of their functions on the membranes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ペルオキシソーム膜ABCタンパク質のペルオキシソーム膜選択的局在化機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ABC subfamily D proteins and very long chain fatty acid metabolism as novel targets in adrenoleukodystrophy.2011

Author(s)

Journal Title

Data Source

[Journal Article] ABC subfamily D proteins and very long chain fatty acid metabolism as novel targets in adrenoleukodystrophy2011

Author(s)

Journal Title

Data Source

[Journal Article] Identification of a substrate-binding site in a peroxisomal β-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative.2010

Author(s)

Journal Title

Data Source

[Journal Article] Multiple organelle-targeting signals in the N-terminal portion of peroxisomal membrane protein PMP70.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Identification of a substrate-binding site in a peroxisomal n-oxidation enzyme by photoaffinity labeling with a novel palmitovl derivative.2010

Author(s)

Journal Title

Data Source

[Journal Article] Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p.2010

Author(s)

Journal Title

Data Source

[Journal Article] Identification of a substrate-binding site in a peroxisomal β-oxidationenzyme by photoaffinity labeling with a novel palmitoyl derivative.2010

Author(s)

Journal Title

Data Source

[Journal Article] 70-kDa peroxisomal membrane protein related protein(P70R/ABCD4)localizes to endoplasmic reticulum not peroxisomes, and NH_2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins.2009

Author(s)

Journal Title

Data Source

[Journal Article] Characterization of the interaction between recombinant human peroxin Pex3p and Pex19p : Identification of TRP104 in Pex3p as a critical residue for the interaction.2008

Author(s)

Journal Title

Data Source

[Journal Article] 70-kDa peroxisomal membrane protein related protein (p70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH_2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins.2008

Author(s)

Journal Title

Data Source

[Journal Article] Hydrophobic regions adjacent to transmembrane domain 1 and 5 are important for the targeting of the 70-kDa peroxisomal membrane protein.2007

Author(s)

Journal Title

Data Source

[Presentation] A new therapeutic approach for trypanosome protozoa: Screening of chemical compounds that inhibit biogenesis of glycosome.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] グリコソーム形成因子をターゲットとした新規抗トリパノソーマ薬の開発．2013

Author(s)

KASHIWAYAMA Yoshinori 柏山恭範