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MITSUI Tetsuo  三井 哲雄

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Mitsui Tetsuo  三井 哲雄

MITSUI Tetuo  三井 哲雄

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Researcher Number 20402084
Other IDs
Affiliation (Current) 2025: 常葉大学, 社会環境学部, 教授
Affiliation (based on the past Project Information) *help 2019: 常葉大学, 社会環境学部, 准教授
2017 – 2018: 山梨大学, 大学院総合研究部, 助教
2016: 山梨大学, 総合研究部, 助教
2014: 山梨大学, 大学院総合研究部, 助教
2012: 山梨大学, 医学工学総合研究部, 助教 … More
2010 – 2012: 山梨大学, 大学院・医学工学総合研究部, 助教
2008: University of Yamanashi, 大学院医学工学総合研究部, 助教
2007 – 2008: University of Yamanashi, 大学院・医学工学総合研究部, 助教
2007: 山梨大, 医学工学総合研究部, 助手
2006: 山梨大学, 大学院医学工学総合研究部, 助手 Less
Review Section/Research Field
Principal Investigator
Obstetrics and gynecology / Environmental physiology(including physical medicine and nutritional physiology)
Except Principal Investigator
Environmental physiology (including Physical medicine and Nutritional physiology)
Keywords
Principal Investigator
エストロジェン / 細胞増殖 / シグナル伝達 / 遺伝子 / 下垂体 / マイクロアレイ / ゲノム編集 / 遺伝子発現 / 膜受容体 / Proliferation … More / Lactotroph / Gpr30 / Estrogen / microRNA … More
Except Principal Investigator
エストロジェン / プロラクチン産生細胞 / 下垂体前葉 / 細胞増殖 / 下垂体 / Rasd1 / プロモクリプチン / ERE / ブロモクリプチン / ドーパミン受容体 / エストロジェン反応性配列 / エストロジェン受容体 / 系統差 / 老化、内分泌 / 成長 / 発達 Less
  • Research Projects

    (7 results)
  • Research Products

    (43 results)
  • Co-Researchers

    (4 People)
  •  Generation of estrogen membrane receptor-deficient rat by genome editing and elucidation for the mechanism of anti-mitogenic actionPrincipal Investigator

    • Principal Investigator
      Mitsui Tetsuo
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental physiology(including physical medicine and nutritional physiology)
    • Research Institution
      Tokoha University
      University of Yamanashi
  •  Identification of the gene involved in the anti-proliferative action of estrogen

    • Principal Investigator
      ARITA Jun
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental physiology (including Physical medicine and Nutritional physiology)
    • Research Institution
      University of Yamanashi
  •  Identification of the microRNA which is involved in theanti-proliferative action of estrogensPrincipal Investigator

    • Principal Investigator
      MITSUI Tetsuo
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      University of Yamanashi
  •  Molecular mechanism for the interaction between estrogen receptor and G protein-coupled receptor

    • Principal Investigator
      ARITA Jun
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental physiology (including Physical medicine and Nutritional physiology)
    • Research Institution
      University of Yamanashi
  •  Rat strain difference in estrogen responsiveness of cell proliferation

    • Principal Investigator
      ARITA Jun
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental physiology (including Physical medicine and Nutritional physiology)
    • Research Institution
      University of Yamanashi
  •  Study on the mechanisms for the antimitogenic action of estrogensPrincipal Investigator

    • Principal Investigator
      MITSUI Mitsui
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      University of Yamanashi
  •  細胞増殖に対するエストロジェンの抑制作用に関する分子機構の解明Principal Investigator

    • Principal Investigator
      三井 哲雄
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      University of Yamanashi

All 2018 2017 2016 2015 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

  • [Journal Article] Activation of G protein-coupled estrogen receptor 1 mimics, but does not mediate, the anti-proliferative action of estradiol on pituitary lactotrophs in primary culture2017

    • Author(s)
      Tetsuo MITSUI, Maho ISHIDA, Michi IZAWA, Jun ARITA
    • Journal Title

      Endocr J

      Volume: 64 Issue: 1 Pages: 103-115

    • DOI

      10.1507/endocrj.EJ16-0079

    • NAID

      130005305882

    • ISSN
      0918-8959, 1348-4540
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16K08522
  • [Journal Article] <i>Rasd1</i> is an estrogen-responsive immediate early gene and modulates expression of late genes in rat anterior pituitary cells2017

    • Author(s)
      Linghong Wang, Tetsuo Mitsui, Maho Ishida, Michi Izawa, Jun Arita
    • Journal Title

      Endocr J

      Volume: 64 Issue: 11 Pages: 1063-1071

    • DOI

      10.1507/endocrj.EJ17-0148

    • NAID

      130006225026

    • ISSN
      0918-8959, 1348-4540
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08522
  • [Journal Article] Global gene expression profiling of the inhibitory effect of estrogen on the cell proliferation of MDA-MB-231 breast cancer cells stably transfected with estrogen receptor2015

    • Author(s)
      M Ishida, T Mitsui, M Izawa, J Arita
    • Journal Title

      Journal of Physiological Sciences

      Volume: 65

    • Data Source
      KAKENHI-PROJECT-24590297
  • [Journal Article] Differences between rat strains in the development of PRL-secreting pituitary tumors with long-term estrogen treatment: In vitro insulin-like growth factor-1-induced lactotroph proliferation and gene expression are affected in Wistar-Kyoto rats with low estrogen-susceptibility2013

    • Author(s)
      Mitsui, T., Ishida, M., Izawa, M., Arita, J.
    • Journal Title

      Endocrine Journal

      Volume: 60 Pages: 1251-1259

    • NAID

      130004770398

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590297
  • [Journal Article] Activation of D2 dopamine receptors inhibits estrogen response element-mediated estrogen receptor transactivation in rat pituitary lactotrophs.2013

    • Author(s)
      Ishida, M., Mitsui, T., Izawa, M., Arita, J.
    • Journal Title

      Molecular & Cellular Endocrinology

      Volume: 375 Pages: 58-67

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590297
  • [Journal Article] Mechanism for the anti-proliferative action of estrogen on lactotroph proliferation2012

    • Author(s)
      Tetsuo Mitsui
    • Journal Title

      Journal of Physiological Sciences

      Volume: 62

    • Data Source
      KAKENHI-PROJECT-22591819
  • [Journal Article] Mechanism for the anti-proliferative action of estrogen on lactotroph proliferation2012

    • Author(s)
      Tetsuo Mitsui
    • Journal Title

      Journal of Physiological Sciences

      Volume: 62

    • Data Source
      KAKENHI-PROJECT-24590297
  • [Journal Article] Mechanism forthe anti-proliferative action of estrogen onlactotroph proliferation2012

    • Author(s)
      Mitsui T, Ishida M, Arita J
    • Journal Title

      J. Physiol. Sci.

      Volume: 62

    • Data Source
      KAKENHI-PROJECT-22591819
  • [Journal Article] Inhibition of Bcl3 gene expression mediates the anti-proliferative action of estrogen in pituitary lactotrophs in primary culture2011

    • Author(s)
      Mitsui T, Ishida M, Izawa M, Kagami Y, Arita J
    • Journal Title

      Molecular and Cellular Endocrinology

      Volume: 345 Pages: 68-78

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591819
  • [Journal Article] Inhibition of Bcl3 gene expression mediates the anti-proliferative action of estrogen in pituitary lactotrophs in primary culture2011

    • Author(s)
      Mitsui Tetsuo
    • Journal Title

      Molecular and Cellualr Endocrinology

      Volume: 345 Issue: 1-2 Pages: 68-78

    • DOI

      10.1016/j.mce.2011.07.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590254
  • [Journal Article] cAMP response element-bindingprotein (CREB) is required for epidermalgrowth factor (EGF)-induced cellproliferation and serum response elementactivation in neural stem cells isolated fromthe forebrain subventricular zone of adultmice.2011

    • Author(s)
      Iguchi H, Mitsui T, Ishida M, Kanba S,Arita J
    • Journal Title

      Endocr. J.

      Volume: 58 Pages: 747-59

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591819
  • [Journal Article] Fetal exposure to2,3,7,8-tetrachlorodibenzo-p-dioxininduces expression of the chemokine genesCxcl4 and Cxcl7 in the perinatal mousebrain2011

    • Author(s)
      Mitsui T, Taniguchi N, Kawasaki N,Kagami Y, Arita J
    • Journal Title

      J. Appl. Toxicol.

      Volume: 31 Pages: 279-284

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591819
  • [Journal Article] Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces expression of the chemokine genes Cxcl4 and Cxcl7 in the perinatal mouse brain2011

    • Author(s)
      Mitsui T, Taniguchi N, Kawasaki N, Kagami Y, Arita J
    • Journal Title

      Journal of applied toxicology

      Volume: 31 Pages: 279-284

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591819
  • [Journal Article] Inhibition of Bcl3 gene expressionmediates the anti-proliferative action ofestrogen in pituitary lactotrophs in primaryculture2011

    • Author(s)
      Mitsui T, Ishida M, Izawa M, Kagami Y,Arita J
    • Journal Title

      Mol. Cell. Endocrinol

      Volume: 345 Pages: 68-78

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591819
  • [Journal Article] Fetal exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD)induces expression of the chemokine genes Cxc14 and Cxc17 in the perinatal mouse brain2011

    • Author(s)
      Mitsui Tetsuo
    • Journal Title

      Journal of Applied Toxicology

      Volume: 31(in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590254
  • [Journal Article] Fetal exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD) induces expression of the chemokine genes Cxcl4 and Cxcl7 in the perinatal mouse brain2011

    • Author(s)
      Mitsui, T., Taniguchi, N., Kawasaki, N., Kagami, Y., Arita, J.
    • Journal Title

      Journal of Applied Toxicology

      Volume: 31 Pages: 279-284

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590254
  • [Journal Article] Inhibition of Bcl3 gene expression mediates the anti-proliferative action of estrogen in pituitary lactotrophs in primary culture2011

    • Author(s)
      Mitsui, T., Ishida, M., Izawa, M., Kagami, Y., Arita, J.
    • Journal Title

      Molecular & Cellular Endocrinology

      Volume: 345 Pages: 68-78

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590254
  • [Journal Article] cAMP response element-binding protein(CREB) is required for epidermal growth factor(EGF)-induced cell proliferation and serum response element activation in neural stem cells isolated from the forebrain subventricular zone of adult mice2011

    • Author(s)
      Iguchi, H., Mitsui, T., Ishida, M., Kanba, S., Arita, J.
    • Journal Title

      Endocrine Journal

      Volume: 58 Pages: 747-759

    • NAID

      10029862663

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590254
  • [Journal Article] cAMP response element-binding protein (CREB) is required for epidermal growth factor (EGF)-induced cell proliferation and serum response element activation in neural stem cells isolated from the forebrain subventricular zone of adult mice2011

    • Author(s)
      Iguchi H, Mitsui T, Ishida M, Kanba S, Arita J
    • Journal Title

      Endocrine Journal

      Volume: 58 Pages: 747-759

    • NAID

      10029862663

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591819
  • [Journal Article] Absence of ligand-independent transcriptional activation of the estrogen receptor via the estrogen response element in pituitary lactotrophs in primary culture2010

    • Author(s)
      Ishida, M., Mitsui T., Izawa M., Arita, J.
    • Journal Title

      Journal of Steroid Biochemistry and Molecular Biology

      Volume: 118 Pages: 93-101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590254
  • [Journal Article] Absence of ligand-independenttranscriptional activation of the estrogenreceptor via the estrogen response elementin pituitary lactotrophs in primary culture2010

    • Author(s)
      Ishida M, Mitsui T, Izawa M, Arita J
    • Journal Title

      J.Steroid Biochem. Mol. Biol.

      Volume: 118 Pages: 93-101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591819
  • [Journal Article] Adenovirus vectors differentially modulate proliferation of pituitary lactotrophs in primary culture in a mitogen and infection time-dependent manner2008

    • Author(s)
      Wang Z., Mitsui T., Ishida M., Arita J.
    • Journal Title

      Journal of Endocrinology 198

      Pages: 209-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19791144
  • [Journal Article] Adenovirus vectors differentially modulate proliferation of pituitary lactotrophs in primary culture in a mitogen and infection time-dependent manner2008

    • Author(s)
      Z Wang, T Mitsui, M Ishida, J Arita
    • Journal Title

      Journal of Endocrinology 198

      Pages: 209-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590224
  • [Journal Article] Involvement of cAMP response element-binding protein in the regulation of cell proliferation and the prolactin promoter of lactotrophs in primary culture2007

    • Author(s)
      M Ishida, T Mitsui, K Yamakawa, N Sugiyama, W Takahashi, H Shimura, T Endo, T Kobayashi, J Arita
    • Journal Title

      American Journal of Physiology, Endocrinology & Metabolism

      Pages: 1529-1537

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590224
  • [Presentation] Rasd1はエストロゲン応答性初期遺伝子でありラット下垂体前葉細胞において後期遺 伝子発現を調節する2018

    • Author(s)
      三井哲雄、石田真帆、有田順
    • Organizer
      第95回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-16K08522
  • [Presentation] エストロジェンによるMDA-ER細胞の増殖抑制作用に対するBCAR3およびFOSL1遺伝子の関与の検討2017

    • Author(s)
      石田真帆、三井哲雄、有田順、宇賀貴紀
    • Organizer
      第64回中部日本生理学会
    • Data Source
      KAKENHI-PROJECT-16K08522
  • [Presentation] Gpr30の活性化は、非ゲノム的作用により下垂体前葉のプロラクチン産生初代培養細胞に対するエストラジオールの増殖抑制作用を模倣する2017

    • Author(s)
      三井 哲雄、石田 真帆、有田 順、宇賀 貴紀
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Data Source
      KAKENHI-PROJECT-16K08522
  • [Presentation] エストロジェンの増殖抑制作用に関与する遺伝子発現解析2017

    • Author(s)
      三井哲雄、石田真帆、有田順、宇賀貴紀
    • Organizer
      第64回中部日本生理学会
    • Data Source
      KAKENHI-PROJECT-16K08522
  • [Presentation] エストロジェンの膜受容体Gpr30を介した細胞増殖調節機構2016

    • Author(s)
      三井 哲雄、石田 真帆、有田 順
    • Organizer
      第63回中部日本生理学会
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県・岡崎市)
    • Data Source
      KAKENHI-PROJECT-16K08522
  • [Presentation] エストロジェンの増殖抑制作用にGPCRスーパーファミリーのメンバーであるGPR30は関与するのか2016

    • Author(s)
      三井 哲雄、石田 真帆、有田 順
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      日本科学未来館(東京都・江東区)
    • Data Source
      KAKENHI-PROJECT-16K08522
  • [Presentation] プロラクチン産生細胞の細胞増殖に対するエストロジェンの抑制作用の発現機構2012

    • Author(s)
      三井哲雄
    • Organizer
      第89回日本生理学会大会「下垂体の機能調節に関わる新規分子の解明」シンポジウム
    • Place of Presentation
      (長野県松本市)
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-21590254
  • [Presentation] プロラクチン産生細胞の細胞増殖に対するエストロジェンの抑制作用の発現機構2012

    • Author(s)
      三井哲雄、 石田真帆、 有田順
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-22591819
  • [Presentation] プロラクチン産生細胞の細胞増殖に対するエストロジェンの抑制作用の発現機構2012

    • Author(s)
      三井哲雄
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-22591819
  • [Presentation] Wistar系及び Wistar/Kyoto 系ラットにおけるプロラクチン産生細胞増殖及び遺伝子発現に対するエストラジオール及びIGF-1 の作用2011

    • Author(s)
      有田順、石田真帆、三井哲雄
    • Organizer
      第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-29
    • Data Source
      KAKENHI-PROJECT-22591819
  • [Presentation] IGF-1 依存性のエストロジェンによる増殖抑制作用には Bcl3 遺伝子発現の抑制が関与する2011

    • Author(s)
      三井哲雄、石田真帆、有田順
    • Organizer
      第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-29
    • Data Source
      KAKENHI-PROJECT-22591819
  • [Presentation] IGF-1依存性のエストロゲンによる増殖抑制作用にはBcl3遺伝子発現の抑制が関与する2011

    • Author(s)
      三井哲雄
    • Organizer
      第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会
    • Place of Presentation
      パシフィコ横浜(東日本大震災の為誌上開催)
    • Year and Date
      2011-03-29
    • Data Source
      KAKENHI-PROJECT-22591819
  • [Presentation] Absence of ligand-independenttranscriptional activation of the estrogenreceptor via the estrogen response elementin pituitary lactotrophs in primary culture2010

    • Author(s)
      Ishida M, Mitsui T, Izawa M, Arita J
    • Organizer
      14th International Congress ofEndocrinology
    • Place of Presentation
      京都
    • Year and Date
      2010-03-29
    • Data Source
      KAKENHI-PROJECT-22591819
  • [Presentation] プロラクチン産生細胞の増殖制御に関するエストロジェン作用、公募シンポジウム「下垂体前葉細胞の分化制御の新展開」2009

    • Author(s)
      石田真帆、三井哲雄、有田順
    • Organizer
      第82 回日本内分泌学会学術総会
    • Place of Presentation
      前橋
    • Year and Date
      2009-04-24
    • Data Source
      KAKENHI-PROJECT-19590224
  • [Presentation] プロラクチン産生細胞の増殖制御に関するエストロジェン作用2009

    • Author(s)
      石田真帆、三井哲雄、有田順
    • Organizer
      公募シンポジウム「下垂体前葉細胞の分化制御の新展開」第82回日本内分泌学会学術総会
    • Place of Presentation
      前橋
    • Year and Date
      2009-04-24
    • Data Source
      KAKENHI-PROJECT-19791144
  • [Presentation] 下垂体プロラクチン産生細胞の増殖に対するアデノウィルス感染の影響2007

    • Author(s)
      三井哲雄
    • Organizer
      第34回日本神経内分泌学会
    • Place of Presentation
      前橋
    • Year and Date
      2007-08-05
    • Data Source
      KAKENHI-PROJECT-19590224
  • [Presentation] 下垂体プロラクチン産生細胞の増殖に対するアデノウィルス感染の影響2007

    • Author(s)
      三井哲雄、王振華、石田真帆、有田順
    • Organizer
      第34 回日本神経内分泌学会
    • Place of Presentation
      前橋
    • Year and Date
      2007-08-05
    • Data Source
      KAKENHI-PROJECT-19590224
  • [Presentation] 下垂体プロラクチン産生細胞の増殖に対するアデノウィルス感染の影響2007

    • Author(s)
      三井哲雄、王振華、石田真帆、有田順
    • Organizer
      第54回中部日本生理学会
    • Place of Presentation
      三重
    • Year and Date
      2007-10-20
    • Data Source
      KAKENHI-PROJECT-19791144
  • [Presentation] 下垂体プロラクチン産生細胞の増殖に対するアデノウィルス感染の影響2007

    • Author(s)
      三井哲雄、王振華、石田真帆、有田順
    • Organizer
      第34回日本神経内分泌学会
    • Place of Presentation
      前橋
    • Year and Date
      2007-08-05
    • Data Source
      KAKENHI-PROJECT-19791144
  • 1.  ISHIDA Maho (80362086)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 10 results
  • 2.  ARITA Jun (80128587)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 11 results
  • 3.  WANG Linghong
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  IZAWA Michi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results

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