Higashitsuji Hisako 東辻久子

… Alternative Names

HIGASHITSUJI Hisako 東辻久子

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Researcher Number	20402852
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2012 – 2014: 京都大学, 医学(系)研究科(研究院), 助教 2007 – 2011: Kyoto University, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Obstetrics and gynecology
Keywords	Principal Investigator 卵巣癌 / ガンキリン / がん抑制遺伝子 / 卵巣がん / プロテアソーム / 癌遺伝子 / pRB / E3 ubiquitin ligase / NEDD8 / p53 … More / mdm2 / synthetic biology / polyubiquitylation / 26S proteasome / S6 ATPase / mononeddylation / gankyrin / 脱アセチル化酵素 / ヒストン / SIRT1 / HDAC1 / 活性化因子 / ヒストン脱アセチル化酵素 / HSCO / MDM2 / ISG15 / nedd8 / PIP / モノユビキチン化 / モノユビキチン Less

Mechanism of ovarian carcinogenesis due to 26S proteasome activation by protooncogene gankyrin mononeddylationPrincipal Investigator
- Principal Investigator
  
  HIGASHITSUJI Hisako
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Analysis of ovarian tumourigenesis due to activators for histone deacetylases(HDACs) that are highly overexpressed in cancersPrincipal Investigator
- Principal Investigator
  
  HIGASHITSUJI Hisako
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Analysis of ovarian carcinogenesis due to monoubiquitylation of gankyrin that is one of proteasome-interacting -proteins (PIPs)Principal Investigator
- Principal Investigator
  
  HIGASHITSUJI Hisako
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University

All 2014 2013 2012 2011 2010 2009 2008 2007 2005 2004 Other

All Journal Article Presentation

[Journal Article] Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1.2014
- Author(s)
  Liu Y, Higashitsuji H, Higashitsuji H, Itoh K, Sakurai T, Koike K, Hirota K, Fukumoto M, Fujita J.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 432(1) Pages: 22-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592514
[Journal Article] Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer.2014
- Author(s)
  Sakurai T, Kashida H, Watanabe T, Hagiwara S, Mizushima T, Iijima H, Nishida N, Higashitsuji H, Fujita J, Kudo M.
- Journal Title
  
  Cancer Res.
  
  Volume: 74 Pages: 6119-28
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592514
[Journal Article] Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production.2013
- Author(s)
  Sakurai T, Kudo M, Watanabe T, Itoh K, Higashitsuji H, Arizumi T, Inoue T, Hagiwara S, Ueshima K, Nishida N, Fukumoto M, Fujita J.
- Journal Title
  
  Dig Dis
  
  Volume: 31 Issue: 5-6 Pages: 440-6
- DOI
  10.1159/000355242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590998, KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24590997, KAKENHI-PROJECT-24592446, KAKENHI-PROJECT-24592514, KAKENHI-PROJECT-24659174, KAKENHI-PROJECT-24659362
[Journal Article] Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice2012
- Author(s)
  Masuda T, et al.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109 Issue: 27 Pages: 10885-108901
- DOI
  10.1073/pnas.1121524109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20670006, KAKENHI-PROJECT-23590998, KAKENHI-PROJECT-23592330, KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-23790332, KAKENHI-PROJECT-24592446, KAKENHI-PROJECT-24592514, KAKENHI-PROJECT-24659174, KAKENHI-PROJECT-24659362
[Journal Article] Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells.2012
- Author(s)
  Sumitomo Y, Higashitsuji H, Higashitsuji H, Liu Y, Fujita T, Sakurai T, et al
- Journal Title
  
  BMC Biotechnol
  
  Volume: 12 Issue: 1 Pages: 72-72
- DOI
  10.1186/1472-6750-12-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590998, KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24592446, KAKENHI-PROJECT-24592514, KAKENHI-PROJECT-24659362
[Journal Article] Adriamycin enhances proteasome-mediated generation of the proapoptotic processed form of MAGE-A4 in hepatoma cells2011
- Author(s)
  Sakurai T, Kudo M, Itoh K, Ryu U, Higashitsuji H, Fujita J.
- Journal Title
  
  Oncology
  
  Volume: 81 Issue: Suppl. 1 Pages: 30-5
- DOI
  10.1159/000334307
- Data Source
  KAKENHI-PROJECT-21592129
[Journal Article] MDM2 is a novel E3 ligase for HIV-1 Vif2009
- Author(s)
  Izumi T, Takaori-Kondo A, Shirakawa K, Higashitsuji H, Itoh K, Io K, Matsui M, Iwai K, Kondoh H, Sato T, Tomonaga M, Ikeda S, Akari H, Koyanagi Y, Fujita J, Uchiyama T.
- Journal Title
  
  Retrovirology
  
  Volume: 6 Issue: 1 Pages: 1-10
- DOI
  10.1186/1742-4690-6-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592129
[Journal Article] Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance2008
- Author(s)
  Ortiz CM, Ito T, Tanaka E, Tsunoda S, Nagayama S, Sakai Y, Higashitsuji H, Fujita J, Shimada Y.
- Journal Title
  
  Int J Cancer
  
  Volume: 122 Issue: 2 Pages: 325-332
- DOI
  10.1002/ijc.23106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592129
[Journal Article] Association of gankyrin protein expression with early clinical stages and IGFBP-5 expression in human hepatocellular carcinoma2008
- Author(s)
  Umemura A, Itoh Y, Itoh K, Yamaguchi K, Nakajima T, Higashitsuji H, Onoue H, Fukumoto M, Okanoue T, Fujita J
- Journal Title
  
  Hepatology 47(2)
  
  Pages: 493-502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591931
[Journal Article] A novel protein overexpressed in hepatoma accelerates export of NF-kappaB from the nucleus and inhibits p53-dependent apoptosis2008
- Author(s)
  Higashitsuji H, Higashitsuji H, Nagao T, Nonoguchi K, Fujii S, Itoh K, Fujita J
- Journal Title
  
  Cancer Cell 2(4)
  
  Pages: 335-346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591931
[Journal Article] Association of gankyrin protein expression with early clinical stages and IGFBP-5 expression in human hepatocellular carcinoma2008
- Author(s)
  Umemura A, Itoh Y, Itoh K, Yamaguchi K, Nakajima T, Higashitsuji H, Onoue H, Fukumoto M, Okanoue T, Fujita J.
- Journal Title
  
  Hepatology
  
  Volume: 47(2) Issue: 2 Pages: 493-502
- DOI
  10.1002/hep.22027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592129
[Journal Article] Association of gankyrin protein expression with early clinical stages and insulin-like growth factor-binding protein 5 expression in human hepatocellular carcinoma.2008
- Author(s)
  Umemura, A., Itoh. Y., Itoh, K., Yamaguchi, K., Nakajima. T., Higashitsuji, H., Onoue, H., Fukumoto, M., Okanoue, T., Fujita, J.
- Journal Title
  
  Hepatology 47
  
  Pages: 493-502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591931
[Journal Article] Enhanced deacetylation of p53 by the anti-apoptotic protein HSCO in association with histone deacetylase 1.2007
- Author(s)
  Hisako Higashitsuji, et. al.
- Journal Title
  
  J Biol Chem 282
  
  Pages: 13716-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591931
[Journal Article] The oncoprotein gankyrin interacts with RelA and suppresses NF kappaB activity2007
- Author(s)
  Higashitsuji H, Higashitsuji H, Liu Y, Masuda T, Fujita T, Abdel-Aziz HI, Kongkham S, Dawson S, John Mayer R, Itoh Y, Sakurai T, Itoh K, Fujita J
- Journal Title
  
  Biochem Biophys Res Commun 363(3)
  
  Pages: 879-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591931
[Journal Article] Enhanced deacetylation of p53 by the anti-apoptotic protein HSCO1 in association with histone deacetylase 12007
- Author(s)
  Higashitsuji H, Higashitsuji H, Masuda T, Liu Y, Itoh K, Fujita J
- Journal Title
  
  J Biol Chem 282(18)
  
  Pages: 13716-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591931
[Journal Article] The oncoprotein gankyrin interacts with RelA and suppresses NFkappaB activity.2007
- Author(s)
  Hiroaki Higashitsuji, et. al.
- Journal Title
  
  Biochem Biophys Res Commun 363
  
  Pages: 879-884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591931
[Journal Article] The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p532005
- Author(s)
  Higashitsuji H, Higashitsuji H, Itoh K,Sakurai T, Nagao T, Sumitomo Y, Masuda T, Dawson S, Shimada Y, Mayer RJ, Fujita J
- Journal Title
  
  Cancer Cell 8(1)
  
  Pages: 75-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591931
[Journal Article] Management of ovarian hyperstimulation due to follicle -stimulating hormone-secreting gonadotroph adenoma2004
- Author(s)
  Murakami T, Higashitsuji H, Yoshinaga K, Terada Y, Ito K, Ikeda H
- Journal Title
  
  BJOG 111(11)
  
  Pages: 1297-1300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591931
[Presentation] Overexpression of gankyrin in mouse hepatocytes induces hemangioma.2013
- Author(s)
  東辻宏明、東辻久子、藤田潤
- Organizer
  第２１回JDDW２０１３
- Place of Presentation
  東京都品川区
- Data Source
  KAKENHI-PROJECT-24592514
[Presentation] ほ乳類低温ショックタンパク質Cirpは皮膚創傷治癒を促進する2013
- Author(s)
  藤田潤、東辻久子、東辻宏明
- Organizer
  第８回臨床ストレス応答学会
- Place of Presentation
  松本市、信州大学医学部付属病院、大会議室
- Data Source
  KAKENHI-PROJECT-24592514
[Presentation] ACC1脂質代謝系酵素によるBRCA1のhomologous recombination の調節機序2013
- Author(s)
  東辻宏明、東辻久子
- Organizer
  日本消化器病学会
- Place of Presentation
  鹿児島市
- Data Source
  KAKENHI-PROJECT-24592514
[Presentation] CIRP(cold-inducible RNA binding protein)は癌細胞の浸潤能、転移能を亢進する2011
- Author(s)
  東辻久子
- Organizer
  第63回日本産科婦人科学会学術講演会
- Place of Presentation
  リーガロイヤルホテル大阪、大阪市
- Year and Date
  2011-08-30
- Data Source
  KAKENHI-PROJECT-21592129
[Presentation] CIRP (cold-inducible RNA binding protein)は癌細胞の浸潤能、転移能を亢進する2011
- Author(s)
  東辻久子
- Organizer
  第63回日本産科婦人科学会学術講演会
- Place of Presentation
  大阪市、リーガロイヤルホテル大阪
- Year and Date
  2011-08-30
- Data Source
  KAKENHI-PROJECT-21592129
[Presentation] がん遺伝子CIRP(cold-inducible RNA binding protein)は癌細胞の浸潤能と転移能を亢進させる2010
- Author(s)
  東辻久子
- Organizer
  JDDW2010第52回日本消化器病学会大会
- Place of Presentation
  横浜市パシフィコ横浜
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-21592129
[Presentation] がん遺伝子CIRP(cold-inducible RNA binding protein)は癌細胞の浸潤能と転移能を亢進させる2010
- Author(s)
  東辻久子
- Organizer
  第52回日本消化器病学会大会
- Place of Presentation
  パシフィコ横浜、横浜市
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-21592129
[Presentation] 卵巣癌で過剰発現する癌遺伝子産物ガンキリンは NFkappaB(RelA)と結合しその転写活性化能を抑制する。2009
- Author(s)
  東辻久子
- Organizer
  第61回日本産科婦人科学会学術講演会
- Place of Presentation
  国立京都国際会館、京都市
- Year and Date
  2009-04-05
- Data Source
  KAKENHI-PROJECT-19591931
[Presentation] 卵巣癌で過剰発現する癌遺伝子産物ガンキリンはNFkappaB(RelA)と結合しその転写活性化能を抑制する2009
- Author(s)
  東辻久子
- Organizer
  第61回日本産科婦人科学会学術講演会
- Place of Presentation
  国立京都国際会館、京都市
- Year and Date
  2009-04-05
- Data Source
  KAKENHI-PROJECT-19591931
[Presentation] 卵巣癌で過剰発現するがん遺伝子ガンキリンはNFkappaB(RelA)と結合しその転写活性化能を抑制する2009
- Author(s)
  東辻久子
- Organizer
  第61回日本産科婦人科学会学術講演会
- Place of Presentation
  国立京都国際会館、京都市
- Year and Date
  2009-04-05
- Data Source
  KAKENHI-PROJECT-21592129
[Presentation] 卵巣癌で過剰発現する癌遣伝子産物ガンキリンはNFkappaB(RelA)と結合しその転写活性化能を抑制する。2009
- Author(s)
  東辻久子
- Organizer
  第61回日本産科婦人科学会学術講演会
- Place of Presentation
  国立京都国際会館、京都市
- Year and Date
  2009-04-05
- Data Source
  KAKENHI-PROJECT-21592129
[Presentation] 卵巣癌で過剰発現する抗アポトーシス蛋白HSCOは、脱アセチル化酵素HDAC1をp53にリクルートすることにより、化学療法剤耐性を賦与する2007
- Author(s)
  東辻久子
- Organizer
  第59回日本産科婦人科学会学術講演会
- Place of Presentation
  国立京都国際会館、京都市
- Year and Date
  2007-04-16
- Data Source
  KAKENHI-PROJECT-19591931
[Presentation] 卵巣癌で過剰発現する抗アポトーシス蛋白HSCOは、脱アセチル化酵素HDAC1をp53にリクルートすることにより、化学療法剤耐性を賦与する2007
- Author(s)
  東辻久子
- Organizer
  第59回日本産科婦人科学会学術講演会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2007-04-16
- Data Source
  KAKENHI-PROJECT-19591931
[Presentation] ほ乳類低温ショックタンパク質CIRPはBRCA1による相同組み替えによるDNA修復を促進する
- Author(s)
  東辻久子
- Organizer
  第６９回日本消化器外科学会総会
- Place of Presentation
  郡山市立文化センター
- Year and Date
  2014-07-16 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-24592514

1. KUDO Masatoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 藤田潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 櫻井俊治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Higashitsuji Hisako 東辻 久子

HIGASHITSUJI Hisako 東辻 久子

Research Projects

Research Products

Co-Researchers

Mechanism of ovarian carcinogenesis due to 26S proteasome activation by protooncogene gankyrin mononeddylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of ovarian tumourigenesis due to activators for histone deacetylases(HDACs) that are highly overexpressed in cancersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of ovarian carcinogenesis due to monoubiquitylation of gankyrin that is one of proteasome-interacting -proteins (PIPs)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1.2014

Author(s)

Journal Title

Data Source

[Journal Article] Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer.2014

Author(s)

Journal Title

Data Source

[Journal Article] Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adriamycin enhances proteasome-mediated generation of the proapoptotic processed form of MAGE-A4 in hepatoma cells2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MDM2 is a novel E3 ligase for HIV-1 Vif2009

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance2008

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of gankyrin protein expression with early clinical stages and IGFBP-5 expression in human hepatocellular carcinoma2008

Author(s)

Journal Title

Data Source

[Journal Article] A novel protein overexpressed in hepatoma accelerates export of NF-kappaB from the nucleus and inhibits p53-dependent apoptosis2008

Author(s)

Journal Title

Data Source

[Journal Article] Association of gankyrin protein expression with early clinical stages and IGFBP-5 expression in human hepatocellular carcinoma2008

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of gankyrin protein expression with early clinical stages and insulin-like growth factor-binding protein 5 expression in human hepatocellular carcinoma.2008

Author(s)

Journal Title

Data Source

[Journal Article] Enhanced deacetylation of p53 by the anti-apoptotic protein HSCO in association with histone deacetylase 1.2007

Author(s)

Higashitsuji Hisako 東辻久子

HIGASHITSUJI Hisako 東辻久子