YAMAMOTO Yomiko 山本由弥子

Researcher Number	20403496
Affiliation (Current)	2020: 岡山大学, 医歯薬学総合研究科, 助教
Affiliation (based on the past Project Information) *help	2020: 岡山大学, 医歯(薬)学総合研究科, 助教 2016 – 2019: 岡山大学, 医歯薬学総合研究科, 助教 2011 – 2016: 岡山大学, 医歯(薬)学総合研究科, 助教 2007 – 2013: 岡山大学, 大学院・医歯薬学総合研究科, 助教
Review Section/Research Field	Principal Investigator Biomedical engineering/Biomaterial science and engineering / Biomedical engineering/Biological material science / Basic Section 90120:Biomaterials-related Except Principal Investigator Prosthetic dentistry / 補綴理工系歯学 / Bacteriology (including Mycology) / Prosthodontics/ Dental materials science and / Basic Section 57050:Prosthodontics-related
Keywords	Principal Investigator 細菌 / ボツリヌス神経毒素 / 神経障害性疼痛 / ボツリヌス毒素 / 腸管 / 薬物送達 / 薬物送達システム / 疼痛抑制 / SNAP-25 / SNAREタンパク質 … More Except Principal Investigator … More

ボツリヌス神経毒素の鎮痛効果発現における直接的作用と間接的作用Principal InvestigatorOngoing
- Principal Investigator
  
  山本由弥子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Okayama University
Neuron-glia signal processing for orofacial pain management developmentOngoing
- Principal Investigator
  
  松香芳三
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  The University of Tokushima
神経障害性疼痛に対するボツリヌス療法の前臨床研究Principal InvestigatorOngoing
- Principal Investigator
  
  山本由弥子
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Okayama University
Neural transmission mechanisms of tooth mechanical stimulation -Development of treatment for occlusal dysesthesia patients-
- Principal Investigator
  
  MATSUKA Yoshizo
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  The University of Tokushima
Clarification of molecular mechanisms underlying the analgesic effect of botulinum toxin and applied studyPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO YUMIKO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Okayama University
Development of neuro-regeneration with Botulinum toxin
- Principal Investigator
  
  MATSUKA Yoshizo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Prosthetic dentistry
- Research Institution
  The University of Tokushima
  Okayama University
Development of a new treatment for trigeminal neuron sensitization
- Principal Investigator
  
  MATSUKA Yoshizo
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Prosthetic dentistry
- Research Institution
  The University of Tokushima
  Okayama University
The development of novel drug delivery systems based on the mechanism for intestinal absorption of botulinum toxinsPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Yumiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Okayama University
Establishment of new procedure for botulism including bioterrorism, and application of botulinum toxin to the treatment
- Principal Investigator
  
  OGUMA Keiji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
Basic mechanisms of nociceptive sensitization of first order sensory neuron in trigeminal neuralgia and treatment development
- Principal Investigator
  
  MATSUKA Yoshizo
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Okayama University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] 病原細菌・ウイルス図鑑（ボツリヌス菌）2017
- Author(s)
  小熊惠二、鈴木智典、山本由弥子
- Total Pages
  916
- Publisher
  北海道大学出版会
- ISBN
  9784832982291
- Data Source
  KAKENHI-PROJECT-17K01358
[Book] 人獣共通感染症　改訂3版（ボツリヌス症）2016
- Author(s)
  小熊惠二、山本由弥子、鈴木智典
- Total Pages
  550
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-26350499
[Book] 改訂版人獣共通感染症(ボツリヌス症)2011
- Author(s)
  小熊惠二,山本由弥子,鈴木智典,武士甲一
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-22500427
[Journal Article] Cross-excitation in peripheral sensory ganglia is associated with pain transmission2015
- Author(s)
  Omoto K, Maruhama K, Terayama R, Yamamoto Y, Matsushita O, Sugimoto T, Oguma K, Matsuka Y
- Journal Title
  
  Toxins
  
  Volume: 7 Pages: 2906-2917
- DOI
  10.3390/toxins7082906
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26350499, KAKENHI-PROJECT-26293412
[Journal Article] C produced by Clostridium botulinum type C and D: comparison of gene, enzymatic, and biological activities with those of Clostridium perfringens alpha-toxin.2013
- Author(s)
  Fatmawati NN, Sakaguchi Y, Suzuki T, Oda M, Shimizu K, Yamamoto Y, Sukurai J, Matsushita O, and Oguma K.
- Journal Title
  
  Acta Med. Okayama
  
  Volume: 67 Pages: 9-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500427
[Journal Article] ボツリヌス症:ボツリヌス毒素の構造と機能と、その臨床応用.2012
- Author(s)
  小熊惠二, 山本由弥子, 鈴木智典
- Journal Title
  
  日本臨牀
  
  Volume: 70 Pages: 1329-1337
- Data Source
  KAKENHI-PROJECT-22500427
[Journal Article] Intradermal injection of Botulinum toxin type A alleviates infraorbital nerve constriction-induced thermal hyperalgesia in an operant assay2012
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Maruhama K, Yamamoto Y, Neubert JK, Noland TA, Watanabe K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
- Journal Title
  
  J.Oral Rehabil.
  
  Volume: 39 Pages: 63-72
- DOI
  10.1111/j.1365-2842.2011.02236.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390365, KAKENHI-PROJECT-22500427, KAKENHI-PROJECT-23659897
[Journal Article] ボツリヌス症2012
- Author(s)
  小熊惠二, 山本由弥子, 鈴木智典, 中嶋洋
- Journal Title
  
  臨床と微生物
  
  Volume: 39 Pages: 170-176
- Data Source
  KAKENHI-PROJECT-22500427
[Journal Article] ツリヌス毒素の構造・機能2012
- Author(s)
  鈴木智典, 山本由弥子, 小熊惠二
- Journal Title
  
  日本医事新報
  
  Volume: 4607 Pages: 60-61
- Data Source
  KAKENHI-PROJECT-22500427
[Journal Article] Application of purified botulinum type A neurotoxin to treat experimental trigeminal neuropathy in rats and patients with urinary incontinence and prostatic hyperplasia.2012
- Author(s)
  Matsuka Y, Yokoyama T, Yamamoto Y, Suzuki T, Nishikawa A, Ohyama T, Watanabe T, Kuboki T, Nagai A, Oguma K.
- Journal Title
  
  J. Toxicol.
  
  Volume: (online journal) Pages: 648384-648384
- DOI
  10.1155/2012/648384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390365, KAKENHI-PROJECT-22500427, KAKENHI-PROJECT-23659897
[Journal Article] Peripheral administration of botulinum toxin type A neurotoxin reverses trigeminal neuropathic pain symptoms2011
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Sato K, Watanabe K, Kuboki T, Oguma K
- Journal Title
  
  http://posters.f1000.com/PosterList?posterID=763
- Data Source
  KAKENHI-PROJECT-22390365
[Journal Article] Peripheral administration of botulinum toxin type A neurotoxin reverses trigeminal neuropathic pain symptoms2011
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Sato K, Watanabe K, Kuboki T, Oguma K.
- URL
  http://posters.f1000.com/PosterList?posterID=763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390365
[Journal Article] ボツリヌス中毒-歴史,現状とその問題点-2011
- Author(s)
  小熊惠二, 山本由弥子, 鈴木智典, 門間千枝
- Journal Title
  
  Modern Physician
  
  Volume: 31 Pages: 783-792
- Data Source
  KAKENHI-PROJECT-22500427
[Journal Article] Peripheral administration of Botulinum toxin type A decreases exaggerated neurotransmitter release and reverses neuropathy-induced gene expression changes in trigeminal ganglia2010
- Author(s)
  Kumada A, Matsuka Y, Kitamura Y, Spigelman I, Ishihara Y, Yamamoto Y, Hikasa T, Sonoyama W, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
- URL
  http://posters.f1000.com/Conferences?confID=3&sectID=null&posterID=266.12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390365
[Journal Article] Peripheral administration of Botulinum toxin type A decreases exaggerated neurotransmitter release and reverses neuropathy-induced gene expression changes in trigeminal ganglia2010
- Author(s)
  Kumada A, Matsuka Y, Kitamura Y, Spigelman I, Ishihara Y, Yamamoto Y, Hikasa T, Sonoyama W, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Journal Title
  
  http://posters.f1000.com/Conferences?confID=3&sect ID=null&posterID=266.12
- Data Source
  KAKENHI-PROJECT-22390365
[Journal Article] Botulinum toxin type A (150 kDa)decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction2009
- Author(s)
  Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Yamamoto Y, Sonoyama w, Kuboki
- Journal Title
  
  Neuroscience 259
  
  Pages: 1422-1429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] Botulinum toxin type A (150 kDa) decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction.2009
- Author(s)
  Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Yamamoto Y, Sonoyama W, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
- Journal Title
  
  Neurosceince 159
  
  Pages: 1422-1429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] Botulinum toxin type A (150 kDa) decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction2009
- Author(s)
  Kitamura Y、Matsuka Y、Spigelman I、Ishihara Y、Yamamoto Y、Sonoyama W、Kamioka H、Yamashiro T、Kuboki T、Oguma K
- Journal Title
  
  Neurosceince Vol.159
  
  Pages: 1422-1429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] Botulinum toxin type A(150 kDa)decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction2009
- Author(s)
  Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Yamamoto Y, Sonoyama W, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Journal Title
  
  Neuroscience 259
  
  Pages: 1422-1429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] 三叉神経痛治療のための薬物治療法の開発2009
- Author(s)
  松香芳三, 北村洋一, 山本由弥子, 園山亘, I.Spigelman, 小熊恵二, 窪木拓男
- Journal Title
  
  日本歯科医学会誌 28
  
  Pages: 49-53
- NAID
  10025692891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] Botulinum toxin type A (150 kDa) decreases exaggerated neurotransmitter release from trigerminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction2009
- Author(s)
  Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Yamamoto Y, Sonoyama W, Kuboki T, and Oguma K
- Journal Title
  
  Neuroscience 159
  
  Pages: 1422-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] 三叉神経痛治療のための薬物治療法の開発2009
- Author(s)
  松香芳三、北村洋一、山本由弥子、園山亘、Spigelman Y、小熊恵二、窪木拓男
- Journal Title
  
  日本歯科医学会誌 28巻
  
  Pages: 49-53
- NAID
  10025692891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] Molecular properties of each subcomponent in Clostridium botulinum type B haemagglutinin complex2008
- Author(s)
  Arimitsu H, Sakaguchi Y, Lee JC, Ochi S, Tsukamoto K, Yamamoto Y, Ma S, Tsuji T, and Oguma K
- Journal Title
  
  Microb Pathog. 45
  
  Pages: 142-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] The effect of peripheral administration of botulinum toxin type A in neuropathic pain rats2008
- Author(s)
  Matsuka Y、Kitamura Y、Spigelman I、Akther R、Yamamoto Y、Sonoyama W、Oguma K、Kuboki T
- Journal Title
  
  Toxicon Vol.51
  
  Pages: 7-7
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] Botulinum toxin blocks neurotransmitter release from somata of rat neuropathic trigeminal ganglion neurons2008
- Author(s)
  itamura Y、Matsuka Y、Ishihara Y、Spigelman I、Yamamoto Y、Sonoyama W、Oguma K、Kuboki T
- Journal Title
  
  Toxicon Vol.51
  
  Pages: 6-6
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] 三叉神経痛治療のための薬物治療法の開発2008
- Author(s)
  松香芳三, 北村洋一, 山本由弥子, 園山亘, I. Spigelman, 小熊恵二, 窪木拓男
- Journal Title
  
  日本歯科医学会誌 28
  
  Pages: 49-53
- NAID
  10025692891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] Identification of structural genes for Clostridium botulinum type C neurotoxin-converting phage particles2007
- Author(s)
  Hwang HJ, Lee JC, Yamamoto Y, Sarker MR, Tsuchiya T, Oguma K
- Journal Title
  
  FEMS Microbiol. Lett. 270
  
  Pages: 82-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Cterminal half fragment (50 kDa) of heavy chain components of Clostridium botulinum type C and D neurotoxins can be used as an effective vaccine2007
- Author(s)
  Lee JC, Hwang HJ, Sakaguchi Y, Yamamoto Y, Arimitsu H, Tsuji T, Watanabe T, Ohyama T, Tsuchiya T, and Oguma K
- Journal Title
  
  Microbiol. Immunol 51
  
  Pages: 445-455
- NAID
  10020280881
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Clinical application of Clostridium botulinum type A neurotoxin purified by a simple procedure for patients with urinary incontinence caused by refractory detrusor overactivity2007
- Author(s)
  Lee JC, Yokoyama T, Hwang HJ, Arimitsu H, Yamamoto Y, Kawasaki M, Takigawa T, Takeshi K, Nishikawa A, Kumon H, and Oguma K
- Journal Title
  
  FEMS Immunol. Med. Microbiol. 51
  
  Pages: 201-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Molecular analysis of an extrachromosomal element encoding the C2 toxin gene discovered in Clostridium botulinum type C
- Author(s)
  Sakaguchi Y, Hayashi T, Yamamoto Y, Nakayama K, Zhang K, Ma S, Arimitsu H, and Oguma K
- Journal Title
  
  J Bacteriol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] C型とD型ボツリヌス毒素変換ファージの解析2018
- Author(s)
  阪口義彦、内山淳平、小椋義俊、後藤和義、山本由弥子、松崎茂展、山口明日美、林哲也、小熊惠二、林俊治
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K01358
[Presentation] Pain transmission within peripheral sensory ganglia2015
- Author(s)
  Omoto K, Maruhama K, Yamamoto Y, Sugimoto T, Matsushita O, Neubert JK, Matsuka Y
- Organizer
  Society for Neuroscience
- Place of Presentation
  Chicago (USA)
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293412
[Presentation] 精製A型ボツリヌス毒素の軸索輸送と疼痛抑制効果2014
- Author(s)
  丸濵功太郎，松香芳三，山本由弥子，寺山隆司，杉本朋貞
- Organizer
  日本神経科学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-26293412
[Presentation] Botulinum toxin endocytosis into trigeminal neurons alleviates neuropathic pain2013
- Author(s)
  Maruhama K, Matsuka Y, Yamamoto Y, Terayama R, Komi K, Ono M, Maekawa K, Kamioka H, Yamashiro T, Sugimoto T, Matsushita O, Kuboki T.
- Organizer
  International Association for Dental Research
- Place of Presentation
  (アメリカ)ワシントン州コンベンションセンター
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] Botulinum toxin endocytosis into trigeminal neurons alleviates neuropathic pain2013
- Author(s)
  Maruhama K, Matsuka Y, Yamamoto Y, Terayama R, Komi K, Ono M, Maekawa K, Kamioka H, Yamashiro T, Sugimoto T, Matsushita O, Kuboki T
- Organizer
  International Association for Dental Research
- Place of Presentation
  Washington State Convention Center (Seattle, USA)
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] Botulinum toxin endocytosed trigeminal neurons alleviates neuropathic pain2013
- Author(s)
  Omoto K, Suzuki Y, Maruhama K, Yamamoto Y, Terayama R, Spigelman I, Kamioka H, Maekawa K, Sugimoto T, Matsushita O, Kuboki T, Matsuka Y
- Organizer
  Asia Academic Congress for Temporomandibular Joint
- Place of Presentation
  International Communication Branch (China)
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] E型ボツリヌス毒素は、A型ボツリヌス毒素と異なるメカニズムによりCaco-2細胞に結合する2013
- Author(s)
  山本由弥子
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22500427
[Presentation] E型ボツリヌス毒素は、A型ボツリヌス毒素と異なるメカニズムによりCaco-2細胞に結合する2013
- Author(s)
  山本由弥子,鈴木智典,美間健彦,藤田久美子,横田憲治,松下治,小熊惠二
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  幕張メッセ(千葉)
- Data Source
  KAKENHI-PROJECT-22500427
[Presentation] 神経毒素成分を精製したA型ボツリヌス毒素の三叉神経への取り込みと輸送2012
- Author(s)
  丸濵功太郎, 松香芳三, 山本由弥子, 寺山隆司, 古味佳子, 大野充昭, 前川賢治, 上岡寛, 山城隆, 杉本朋貞, 松下治, 小熊恵二, 窪木拓男
- Organizer
  日本口腔顔面痛学会
- Place of Presentation
  (東京都)慶應義塾大学
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] 神経障害性疼痛へのポツリヌス毒素の効果2012
- Author(s)
  松香芳三,丸〓功太郎,三宅愛,山本由弥子,前川賢治,古味桂子,園山亘,小熊惠二,窪木拓男
- Organizer
  日本歯科医学会総会
- Place of Presentation
  インテックス大阪(大阪府)
- Year and Date
  2012-11-11
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] 神経毒素成分を精製した A 型ボツリヌス毒素の三叉神経への取り込みと輸送2012
- Author(s)
  丸〓功太郎, 松香芳三, 山本由弥子, 寺山隆司, 古味佳子, 大野充昭, 前川賢治, 上岡寛, 山城隆, 杉本朋貞, 松下治, 小熊恵二, 窪木拓男
- Organizer
  日本口腔顔面痛学会
- Place of Presentation
  慶応大学(東京都)
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] 神経障害性疼痛へのポツリヌス毒素の効果2012
- Author(s)
  松香芳三, 丸濵功太郎, 三宅愛, 山本由弥子, 前川賢治, 古味桂子, 園山亘, 小熊惠二, 窪木拓男
- Organizer
  日本歯科医学会総会
- Place of Presentation
  (大阪府)インテックス大阪
- Year and Date
  2012-11-11
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] ボツリヌス菌A型菌変異株が産生するHA複合体の構造に関する研究2011
- Author(s)
  馬少博,鈴木智典,張凱, Ni Nengah Dwi Fatmawati,山本由弥子,藤田久美子,西田菜々,横田憲治,小熊惠二
- Organizer
  第64回日本細菌学会中国・四国支部総会
- Place of Presentation
  岡山大学(岡山)
- Year and Date
  2011-10-23
- Data Source
  KAKENHI-PROJECT-22500427
[Presentation] Medical application of clostridal toxins; 1) Clostridium botulinum neurotoxin2011
- Author(s)
  Oguma K, Yamamoto Y, Suzuki T, Yokoyama T, Matsuka Y, Arimitsu H, Kuboki T
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  Sapporo Convention Center (北海道)
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] Botulinum toxin type A neurotoxin endocytosis into trigeminal neuron and its effect onto neuropathic pain beahavior2011
- Author(s)
  Kumada A, Matsuka Y, Yamamoto Y, Suzuki T, Spigelman I, Neubert JK, Nolan TA, Watanabe K, Maruhama K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  Sapporo Convention Center (北海道)
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] ボツリヌスE型毒素のCaco-2細胞に対する結合性について2011
- Author(s)
  張凱, 山本由弥子,鈴木智典,横田憲治,藤田久美子,西田菜々,馬少博,Ni Nengah Dwi Fatmawati,長町榮子,小熊惠二
- Organizer
  第64回日本細菌学会中国・四国支部総会
- Place of Presentation
  岡山大学(岡山)
- Year and Date
  2011-10-23
- Data Source
  KAKENHI-PROJECT-22500427
[Presentation] Botulinum neurotoxin type A endocytosis into trigeminal neurons and its effect on neuropathic pain behavior2011
- Author(s)
  Maruhama K, Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Suzuki T, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington DC Convention Center (Washington DC, USA)
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] Botulinum toxin type A neurotoxin endocytosis into trigeminal neuron and its effect onto neuropathic pain beahavior2011
- Author(s)
  Kumada A, Matsuka Y, Yamamoto Y, Suzuki T, Spigelman I, Neubert JK, Nolan TA, Watanabe K, Maruhama K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  (北海道)札幌コンベンションセンター
- Year and Date
  2011-09-07
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] Medical application of clostridal toxins; 1) Clostridium botulinum neurotoxin2011
- Author(s)
  Oguma K, Yamamoto Y, Suzuki T, Yokoyama T, Matsuka Y, Arimitsu H, Kuboki T
- Organizer
  International Union of Microbiological Societies 2011 Congress(招待講演)
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] Botulinum neurotoxin type A endocytosis into trigeminal neurons and its effect on neuropathic pain behavior2011
- Author(s)
  Maruhama K, Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Suzuki T, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] Medical application of clostridal toxins; 1) Clostridium botulinum neurotoxin2011
- Author(s)
  Oguma K, Yamamoto Y, Suzuki T, Yokoyama T, Matsuka Y, Arimitsu H, Kuboki T.
- Organizer
  International Union of Microbiological Societies 2011 Congress, Sapporo
- Place of Presentation
  (北海道)札幌コンベンションセンター
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] Botulinum toxin type A neurotoxin endocytosis into trigeminal neuron and its effect onto neuropathic pain beahavior2011
- Author(s)
  Kumada A, Matsuka Y, Yamamoto Y, Suzuki T, Spigelman I, Neubert JK, Nolan TA, Watanabe K, Maruhama K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] Botulinum neurotoxin type A endocytosis into trigeminal neurons and its effect on neuropathic pain behavior2011
- Author(s)
  Maruhama K, Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Suzuki T, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
- Organizer
  Society for Neuroscience
- Place of Presentation
  (アメリカ)ワシントン州コンベンションセンター
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] A型ボツリヌス神経毒素の三叉神経節培養細胞への結合と取り込み2010
- Author(s)
  山本由弥子
- Organizer
  第63回日本細菌学会中国・四国支部総会
- Place of Presentation
  松山大学
- Year and Date
  2010-10-17
- Data Source
  KAKENHI-PROJECT-22500427
[Presentation] 三叉神経障害性疼痛モデルに対する改良A型ボツリヌス毒素の鎮痛効果2010
- Author(s)
  熊田愛, 松香芳三, 北村洋一, Igor Spigelman, 山本由弥子, Todd A.Nolan, John K.Neubert, 石原嘉人, 園山亘, 上岡寛, 山城隆, 小熊恵二, 窪木拓男
- Organizer
  神経行動薬理若手研究者の集い
- Place of Presentation
  岡山
- Year and Date
  2010-03-15
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Peripheral administration of Botulinum toxin type A neurotoxin reverses trigeminal neuropathic pain symptoms2010
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Satoh K, Watanabe K, Kuboki T, Oguma K.
- Organizer
  Society for Neuroscience
- Place of Presentation
  (アメリカ)サンディエゴコンベンションセンター
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] Pepripehral administration of Botlinum toxin type A neurotoxin reverses trigeminal thermal hyperalgesia2010
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Sato K, Watanabe K, Yamamoto K, Murakami K, Kuboki T, Oguma K.
- Organizer
  Asian Academy of Craniomandibular Disorders
- Place of Presentation
  (福岡県)九州大学
- Year and Date
  2010-10-03
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] A型ボツリヌス神経毒素の三叉神経節培養細胞への結合と取り込み2010
- Author(s)
  山本由弥子,張凱,Ni Nengah Dwi Fatmawati,申蓮花,馬少博,阪口義彦, 鈴木智典,小熊惠二
- Organizer
  第63回日本細菌学会中国・四国支部総会
- Place of Presentation
  松山大学(松山).
- Year and Date
  2010-10-17
- Data Source
  KAKENHI-PROJECT-22500427
[Presentation] Peripheral administration of botulinum toxin type A decreases exaggerated neurotransmitter release from somata of trigeminal ganglion neurons and reverses neuropathy symptoms2010
- Author(s)
  Kumada A, Matsuka Y, Kitamura Y, Spigelman I, Yamamoto Y, Nolan TA, Neubert JK, Ishihara Y, Sonoyama W, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Organizer
  International Symposium for Future Technology Creating Better Human Health and Society. Molecular Targets for the Development of Therapeutic Agents against Cancer and Infectious Diseases in vitro, in vivo and in silico
- Place of Presentation
  Okayama
- Year and Date
  2010-02-03
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Pepripehral administration of Botlinum toxin type A neurotoxin reverses trigeminal thermal hyperalgesia2010
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Sato K, Watanabe K, Yamamoto K, Murakami K, Kuboki T, Oguma K
- Organizer
  Asian Academy of Craniomandibular Disorders
- Place of Presentation
  Hakata
- Year and Date
  2010-10-03
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] Peripheral administration of Botulinum toxin type A neurotoxin reverses trigeminal neuropathic pain symptoms2010
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Satoh K, Watanabe K, Kuboki T, Oguma K
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] Association of TMJ-pain, headache and bruxism in non-patient young adults2010
- Author(s)
  Hara ES, Miyawaki S, Minakuchi H, Kataoka T, Matsuka Y, Yamashiro T, Takano-Yamamoto T, Kuboki T
- Organizer
  International Association for Dental Research
- Place of Presentation
  Barcelona
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] C 型とD型ボツリヌスC2毒素遺伝子をコードするプラスミドの解析2009
- Author(s)
  阪口義彦、林哲也、中山恵介、山本由弥子、馬少博、橋本夕佳、張凱、小熊惠二
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] Peripheral administration of botulinum toxin type A decreases exaggerated neurotransmitter release and reverses neuropathy-induced gene expression changes in trigeminal ganglia2009
- Author(s)
  Kumada A、Matsuka Y、Kitamura Y、Spigelman I、Ishihara Y、Yamamoto Y、Hikasa T、Sonoyama W、Kamioka H、Yamashiro T、Kuboki T、Oguma K
- Organizer
  Society for Neuroscience
- Place of Presentation
  Chicago
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Botulinum toxin blocks neurotransmitter release and alleviates neuropathy symptoms2009
- Author(s)
  Kumada A, Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Yamamoto Y, Hikasa T, Kamioka H, Yamashiro T, Sonoyama W, Kuboki T, Oguma K
- Organizer
  The Second International Symposium of Medial and Dental Education in Okayama
- Place of Presentation
  Okayama
- Year and Date
  2009-05-18
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Botulinum toxin blocks neurotransmitter release from somata of rat neuropi2008
- Author(s)
  Kitamura Y, Matsuka Y, Ishihara Y, Spigelman I, Yamamoto Y, Sonoyama w, Oguma K, Kuboki
- Organizer
  Botulinum and Tetanus Toxins 2008
- Place of Presentation
  Baveno
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Botulinum toxin blocks neurotransmitter release from somata of rat neuropathic trigeminal ganglion neurons2008
- Author(s)
  Kitamura Y、Matsuka Y、Ishihara Y、Spigelman I、Yamamoto Y、Sonoyama W、Oguma K、Kuboki T
- Organizer
  Botulinum and Tetanus Toxins 2008
- Place of Presentation
  Baveno
- Year and Date
  2008-06-12
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Peripheral administration of Botulinum toxin type A blocks neurotransmitte2008
- Author(s)
  Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Akther R, Yamamoto Y, Sonoyama W, Oeuma K Kuboki T
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington DC
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] The effect of peripheral administration of botulinum toxin type A in ratswith neuropathic pain2008
- Author(s)
  Yoshizo Matsuka, Yoichi Kitamura, Igor Spigelman, Rahena Akther, Yumiko Yamamoto, Wataru Sonoyama, Keiji Oguma and Takuo Kuboki
- Organizer
  The 6^<th> International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins
- Place of Presentation
  Italy
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] 三叉神経因性疼痛モデルラットにおける改良A型ボツリヌス毒素の効果2008
- Author(s)
  北村洋一、松香芳三、石原嘉人、園山亘、山本由弥子、小熊恵二、窪木拓男
- Organizer
  口腔顔面痛学会
- Place of Presentation
  福岡
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Peripheral administration of Botulinum toxin type A blocks neurotransmitter release from somata of trigeminal ganglion neurons and alleviates neuropathy symptoms2008
- Author(s)
  Kitamura Y、Matsuka Y、Spigelman I、Ishihara Y、Akther R、Yamamoto Y、Sonoyama W、Oguma K、Kuboki T
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington DC
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] The effect of peripheral administration of botulinum toxin type A in neuropa2008
- Author(s)
  Matsuka Y, Kitamura Y, Spigelman I, Akther R, Yamamoto Y, Sonoyama W, Oguma K and
- Organizer
  Botulinum and Tetanus Toxins 2008
- Place of Presentation
  Baveno
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Peripheral administration of Botulinum toxin type A blocks neurotransmitter release from somata of trigeminal ganglion neurons and alleviates neuropathy symptoms2008
- Author(s)
  Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Akther R, Yamamoto Y, Sonoyama W, Oguma K, Kuboki T.
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington DC.
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Botulinum toxin blocks neurotransmitter release from somata of rat neuropathic trigeminal ganglion neurons2008
- Author(s)
  Yoichi, Kitamura, Yoshizo, Matsuka, Yoshihiro, Ishihara, Igor, Spigelman, Yumiko, Yamamoto, Wataru, Sonoyama, Horoshi, Kamioka, Takashi, Yamashiro, Keiji, Oguma and Takuro, Kuboki
- Organizer
  The 6^<th> International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins
- Place of Presentation
  Italy
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] 三叉神経因性疼痛モデルラツトにおける神経伝達物質遊離に対する改良A型ボツリヌス毒素の効果 -神経因性疼痛に対する新規治療法の開発-2008
- Author(s)
  北村洋一, 松香芳三, 山本由弥子, 小熊恵二, 窪木拓男
- Organizer
  先端歯学スクール2008
- Place of Presentation
  三浦
- Year and Date
  2008-10-20
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] 三叉神経因性疼痛モデルラツトにおける改良A型ボツジヌス毒素の効果2008
- Author(s)
  北村洋一, 松香芳三, 石原嘉人, 園山亘, 山本由弥子, 小熊恵二, 窪木拓男
- Organizer
  口腔顔面痛学会
- Place of Presentation
  福岡
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] The effect of peripheral administration of botulinum toxin type A in neuropathic pain rats2008
- Author(s)
  Matsuka Y、Kitamura Y、Spigelman I、Akther R、Yamamoto Y、Sonoyama W、Oguma K、Kuboki T
- Organizer
  Botulinum and Tetanus Toxins 2008
- Place of Presentation
  Baveno
- Year and Date
  2008-06-12
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] 精製A型ボツリヌス毒素の軸索輸送と疼痛抑制効果
- Author(s)
  丸濱功太郎，松香芳三，山本由弥子，寺山隆司，杉本朋貞
- Organizer
  第37回日本神経科学大会 Neuroscience 2014
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26350499
[Presentation] 三叉神経におけるA型ボツリヌス神経毒素の局在と軸索輸送
- Author(s)
  山本由弥子，丸濱功太郎，松香芳三，美間健彦，後藤和義，横田憲治，松下治，小熊惠二
- Organizer
  第67回日本細菌学会中国・四国支部総会
- Place of Presentation
  徳島
- Year and Date
  2014-10-04 – 2014-10-05
- Data Source
  KAKENHI-PROJECT-26350499
[Presentation] ボツリヌス毒素を利用した神経障害性疼痛治療
- Author(s)
  松香芳三，丸濱功太郎，山本由弥子，小熊惠二，松下治
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  岐阜
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26350499

1. MATSUKA Yoshizo (90243477)

# of Collaborated Projects: 7 results

# of Collaborated Products: 56 results
2. OGUMA Keiji (00002262)

# of Collaborated Projects: 6 results

# of Collaborated Products: 67 results
3. KUBOKI Takuo (00225195)

# of Collaborated Projects: 3 results

# of Collaborated Products: 49 results
4. KUMADA Ai (40610895)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
5. 丸濱功太郎 (60712792)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
6. MAEKAWA Kenji (20304313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KANYAMA Manabu (90294420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUGIMOTO Tomosada (50135729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKEI Koji (40322226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ONO Tsuyoshi (80457225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
11. YOKOTA Kenji (00243460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. AYADA Kiyoshi (00379835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SAKAGUCHI Yoshihiko (70403491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
14. ARIMITSU Hideyuki (40367701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. MATSUO Ryuji (30157268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MATSUSHITA Osamu (00209537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. 小川匠 (20267537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 小出隆規 (70322253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 大島正充 (00548307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 岩田幸一 (60160115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KITAMURA Yoichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
22. SPIGELMAN Igor

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
23. NEUBERT John k.

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

YAMAMOTO Yomiko 山本 由弥子

Research Projects

Research Products

Co-Researchers

ボツリヌス神経毒素の鎮痛効果発現における直接的作用と間接的作用Principal InvestigatorOngoing

Principal Investigator

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Review Section

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Neuron-glia signal processing for orofacial pain management developmentOngoing

Principal Investigator

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Review Section

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神経障害性疼痛に対するボツリヌス療法の前臨床研究Principal InvestigatorOngoing

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Neural transmission mechanisms of tooth mechanical stimulation -Development of treatment for occlusal dysesthesia patients-

Principal Investigator

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Clarification of molecular mechanisms underlying the analgesic effect of botulinum toxin and applied studyPrincipal Investigator

Principal Investigator

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Development of neuro-regeneration with Botulinum toxin

Principal Investigator

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Development of a new treatment for trigeminal neuron sensitization

Principal Investigator

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The development of novel drug delivery systems based on the mechanism for intestinal absorption of botulinum toxinsPrincipal Investigator

Principal Investigator

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Establishment of new procedure for botulism including bioterrorism, and application of botulinum toxin to the treatment

Principal Investigator

Project Period (FY)

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Research Institution

Basic mechanisms of nociceptive sensitization of first order sensory neuron in trigeminal neuralgia and treatment development

Principal Investigator

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Research Institution

[Book] 病原細菌・ウイルス図鑑（ボツリヌス菌）2017

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[Book] 人獣共通感染症 改訂3版 （ボツリヌス症）2016

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[Book] 改訂版人獣共通感染症(ボツリヌス症)2011

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[Journal Article] Cross-excitation in peripheral sensory ganglia is associated with pain transmission2015

YAMAMOTO Yomiko 山本由弥子

[Book] 人獣共通感染症　改訂3版（ボツリヌス症）2016