Sugawara Michiko 菅原通子

… Alternative Names

SUGAWARA Kayoko 菅原通子

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Researcher Number	20406458
Other IDs
Affiliation (based on the past Project Information) *help	2013 – 2015: 埼玉医科大学, 医学部, 講師 2011: 埼玉医科大学, 医学部, 助教 2007 – 2008: 埼玉医科大学, 医学部, 助教
Review Section/Research Field	Except Principal Investigator Gastroenterology
Keywords	Except Principal Investigator 性差 / C型慢性肝炎 / 転写因子 / オステオポンチン / Huh7 / ポリメラーゼ / B型慢性肝炎 / 核酸アナログ / cyclingprobereal-timePCR / nucleotide analogs … More / nucleoside / terminal protein domain / polymerase / HCV / HBV / SNP / エストロゲン / Th1系免疫応答 / プロモーターアッセイ / オシテオポンチン / Th1 系免疫応答 / ゲルシフトアッセイ / 性差プロモーターアッセイ / C 型慢性肝炎 / 遺伝子多型 Less

The aa15-17 amino acid sequence in the terminal protein domain of HBV polymerase as a viral factor affect-ing in vivo as well as in vitro replication activity of the virus.
- Principal Investigator
  
  Mochida Satoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical University
Identification of Female-Specific Transcriptional Factors for Osteopontin Translation as a Host Factor to Determine the Difference of Clinical Features of Liver Diseases between Male and Female Patients
- Principal Investigator
  
  MOCHIDA Satoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical University
The regulatory mechanisms of osteopontin expression in as a genetic factor to determine inflammatory grading in the liver of HCV infected patients
- Principal Investigator
  
  MOCHIDA Satoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical University

All 2016 2015 2014 2013 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Development of rare RAVs that are extremely tolerant against NS5A inhibitors during daclatasvir/asunaprevir therapy via a two-hit mechanism.2016
- Author(s)
  Uchida Y, Kouyama J, Naiki K, Sugawara K, Inao M, Imai Y, Nakayama N, Mochida S.
- Journal Title
  
  Hepatology Research
  
  Volume: Feb 15 Issue: 12 Pages: 1234-1246
- DOI
  10.1111/hepr.12673
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] Significance of variants associated with resistance to NS5A inhibitors in Japanese patients with genotype 1b hepatitis C virus infection as evaluated using cycling-probe real-time PCR combined with direct sequencing.2016
- Author(s)
  Uchida Y, Kouyama J, Naiki K, Sugawara K, Ando S, Nakaoa M, Motoya D, Inao M, Imai Y, Nakayama N, Mochida S.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 51 Issue: 3 Pages: 260-270
- DOI
  10.1007/s00535-015-1106-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] Multicenter prospective study to optimize the efficacy of triple therapy with telaprevir in patients with genotype 1b HCV infection according to an algorithm based on the drug adherence, IL28B gene allele and viral response: the AG & RGT Trial.2015
- Author(s)
  Sugawara K, Koushima Y, Inao M, Nakayama N, Nagoshi S, Yakabi K, Tamano M, Asabe S, Mishikawa K, Harada Y, Sekine C, Fukuya Y, Funtny J, Hashimoto Y, Mochida S
- Journal Title
  
  Hepatol Res
  
  Volume: in press Issue: 11 Pages: 1091-1099
- DOI
  10.1111/hepr.12475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] Telaprevir-Induced, but not Pegylated Interferon-Associated, Retinopathy as a Noteworthy Adverse Effect during Triple Antiviral Therapy in Patients with Chronic Hepatitis C.2014
- Author(s)
  Sugawara K, Inao M, Nakayama N, Mochida S.
- Journal Title
  
  J Gastroenterol
  
  Volume: 49 Pages: 363-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] Therapeutic Strategy for Patients with Bleeding Rectal Varices Complicating Liver Cirrhosis.2014
- Author(s)
  Yoshino K, Imai Y, Nakazawa M, Chikayama T, Ando S, Sugawara K,Inao M, Oka M, Mochida S.
- Journal Title
  
  Hepatol Res
  
  Volume: in press Issue: 11 Pages: 1088-1094
- DOI
  10.1111/hepr.12232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] A Possible Novel Genotype HBV Strain Developing Due to Recombination between Genotypes H and B Strains Isolated from a Japanese Patient.2014
- Author(s)
  Uchida Y, Kouyama J, Naiki K, Sugawara K, Inao M, Nakayama N, Mochida S
- Journal Title
  
  Hepatol Res
  
  Volume: in press Issue: 11 Pages: 1130-1141
- DOI
  10.1111/hepr.12238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Journal Article] SNPs in the promoter region of osteopontin gene as a possible host factor for sex difference in hepatocellular carcinoma development in patients with HCV.2013
- Author(s)
  Hamaoka K, Nagoshi S, Sugawara K, Naiki K, Uchida Y, Inao M, Nakayama N, Fujiwara K, Mochida S.
- Journal Title
  
  Hepatol Int
  
  Volume: 7 Issue: 2 Pages: 683-692
- DOI
  10.1007/s12072-012-9404-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461010
[Presentation] Frequent Emergences of Rare RAVs Showing Extreme Resistance to NS5A Inhibitors during Dual Oral Therapy with Daclatasvir Plus Asunaprevir in Patients Previously Receiving Triple Therapy with Simeprevir.2015
- Author(s)
  Yoshihito UCHIDA, Nobuaki NAKAYAMA, Jun-ichi KOUYAMA, Kayoko NAIKI, Hayato UEMURA, Kayoko SUGAWARA, Mie INAO, Satoshi MOCHIDA
- Organizer
  The Liver Meeting, AASLD
- Place of Presentation
  St Francisco,USA
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461010
[Presentation] NS5A領域のアミノ酸変異に基づいたIFNフリー治療の戦略：サイクリング・プローブ法を用いた検討2015
- Author(s)
  内田義人，菅原通子，持田　智
- Organizer
  JDDW 2015
- Place of Presentation
  東京グランドﾌﾟﾘﾝｽホテル新高輪　（東京都港区）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25461010
[Presentation] Estrogen-dependent novel transfer factor as well as SRY may be involved in the sexual differrence in the development of hepatocellular carcinoma in HCV-infected patients through osteopontin expression in the liver2010
- Author(s)
  Hamaoka K, Nagoshi S, Sugawara K, Inao M, Naiki K, Nakayama N, Fujiwara K, Mochida S
- Organizer
  61^<st> Annual Meeting of American Association for the Study of the Liver
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-21590858
[Presentation] 肝病態における性差: Osteopontin遺伝子promoter SNPsに関連する新規転写因子のエストロゲンによる調節機構2010
- Author(s)
  濱岡和宏, 名越澄子, 菅原通子, 内木佳代子, 稲生実枝, 中山伸朗, 藤原研司, 持田智
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-21590858
[Presentation] An unknown transfer factor up-regulated by estrogen may be involved in the sexual difference in the development of hepatocellular carcinoma in HCV-infected patients through osteopontin expression in the liver2010
- Author(s)
  Hamaoka K, Nagoshi S, Sugawara K, Inao M, Naiki K, Nakayama N, Fujiwara K, Mochida S
- Organizer
  45th Annual Meeting of European Association for the Study of the Liver
- Place of Presentation
  Wien, Austria
- Data Source
  KAKENHI-PROJECT-21590858
[Presentation] 肝病態の性差を規定する宿主要因: Osteopontin 遺伝子promoter SNPsと新規転写因子の意義2009
- Author(s)
  濱岡和宏,名越澄子,菅原通子,内木佳代子,稲生実枝,中山伸朗,藤原研司,持田智
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19590788
[Presentation] A novel transfer factor specific to female cells may be involved in the sexual difference in the development of hepatocellular carcinoma in HCV-Infected patients through osteopontin expression in the liver2009
- Author(s)
  Hamaoka K, Nagoshi S, Sugawara K, Inao M, Naiki K, Nakayama N, Fujiwara K, Mochida S
- Organizer
  60th Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-21590858
[Presentation] 肝病態の性差を規定する宿主要因: Osteopontin 遺伝子promoter SNPs nt -155の意義2008
- Author(s)
  菅原通子,名越澄子,内木佳代子,濱岡和宏,稲生実枝,中山伸朗,藤原研司,持田智
- Organizer
  第8回オステオポンチン研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19590788
[Presentation] Hepatic Inflammatory Reaction may be Regulated in Patients with Hepatitis Virus Infection through Osteopontin Expression in Hepatic Macrophages and Hepatocytes Determined by the Genetic Polymorphisms.2007
- Author(s)
  Sugawara K, Nagoshi S, Hamaoka K, Inao M, Naiki K, Nakayama N, Fujiwara K, MochidaS.
- Organizer
  Asian Pacific Digestive Diseases Week (APDW) 2007.
- Place of Presentation
  Kobe, Japan.
- Data Source
  KAKENHI-PROJECT-19590788
[Presentation] The Significance of Osteopontin Promoter SNPs at nt -155 and FoxD3 as Host Factors to Regulate the Development of Hepatocellular Carcinoma in Female Patients with HCV Infection.2007
- Author(s)
  Hamaoka K, Nagoshi S, Sugawara K, Inao M, Naiki K, Naito M, Nakayama M, Fujiwara K, Mochida S.
- Organizer
  57th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Boston, USA.
- Data Source
  KAKENHI-PROJECT-19590788
[Presentation] The aa15-17 Amino Acid Sequence in the Terminal Protein Domain of HBV Polymerase as a Viral Factor Affecting in Vivo as Well as in Vitro Replication Activity of the Virus
- Author(s)
  Uchida Y, Yoshino K, Sugawara K, Kouyama J, Naiki K, Nakayama N, Mochida S
- Organizer
  The liver Meeting 2013 (AASLD)
- Place of Presentation
  Washington,USA
- Data Source
  KAKENHI-PROJECT-25461010

1. MOCHIDA Satoshi (20219968)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
2. INAO Mie (70286037)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. NAKAYAMA Nobuaki (40292015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results

Sugawara Michiko 菅原 通子

SUGAWARA Kayoko 菅原 通子

Research Projects

Research Products

Co-Researchers

The aa15-17 amino acid sequence in the terminal protein domain of HBV polymerase as a viral factor affect-ing in vivo as well as in vitro replication activity of the virus.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of Female-Specific Transcriptional Factors for Osteopontin Translation as a Host Factor to Determine the Difference of Clinical Features of Liver Diseases between Male and Female Patients

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The regulatory mechanisms of osteopontin expression in as a genetic factor to determine inflammatory grading in the liver of HCV infected patients

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Development of rare RAVs that are extremely tolerant against NS5A inhibitors during daclatasvir/asunaprevir therapy via a two-hit mechanism.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Significance of variants associated with resistance to NS5A inhibitors in Japanese patients with genotype 1b hepatitis C virus infection as evaluated using cycling-probe real-time PCR combined with direct sequencing.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multicenter prospective study to optimize the efficacy of triple therapy with telaprevir in patients with genotype 1b HCV infection according to an algorithm based on the drug adherence, IL28B gene allele and viral response: the AG & RGT Trial.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Telaprevir-Induced, but not Pegylated Interferon-Associated, Retinopathy as a Noteworthy Adverse Effect during Triple Antiviral Therapy in Patients with Chronic Hepatitis C.2014

Author(s)

Journal Title

Data Source

[Journal Article] Therapeutic Strategy for Patients with Bleeding Rectal Varices Complicating Liver Cirrhosis.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Possible Novel Genotype HBV Strain Developing Due to Recombination between Genotypes H and B Strains Isolated from a Japanese Patient.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SNPs in the promoter region of osteopontin gene as a possible host factor for sex difference in hepatocellular carcinoma development in patients with HCV.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Frequent Emergences of Rare RAVs Showing Extreme Resistance to NS5A Inhibitors during Dual Oral Therapy with Daclatasvir Plus Asunaprevir in Patients Previously Receiving Triple Therapy with Simeprevir.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] NS5A領域のアミノ酸変異に基づいたIFNフリー治療の戦略：サイクリング・プローブ法を用いた検討2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Estrogen-dependent novel transfer factor as well as SRY may be involved in the sexual differrence in the development of hepatocellular carcinoma in HCV-infected patients through osteopontin expression in the liver2010

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 肝病態における性差: Osteopontin遺伝子promoter SNPsに関連する新規転写因子のエストロゲンによる調節機構2010

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] An unknown transfer factor up-regulated by estrogen may be involved in the sexual difference in the development of hepatocellular carcinoma in HCV-infected patients through osteopontin expression in the liver2010

Sugawara Michiko 菅原通子

SUGAWARA Kayoko 菅原通子