Nakano Takanari 中野貴成

Researcher Number	20406474
Other IDs
Affiliation (Current)	2025: 埼玉医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 埼玉医科大学, 医学部, 准教授 2013 – 2020: 埼玉医科大学, 医学部, 講師 2013: 埼玉医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 38050:Food sciences-related / Eating habits / Integrated Nutrition Science Except Principal Investigator Metabolomics / General physiology
Keywords	Principal Investigator 植物ステロール / 小腸 / 動脈硬化 / Niemann-Pick C1-like 1 / コレステロール逆輸送 / コレステロール / 炎症 / LXR / アポE欠損マウス / Liver-X-Receptor … More / RNAシーケンス / 腸管経由コレステロール逆輸送 / Niemann-Pick C1-like1 / fecal neutral sterol / 腸管吸収 / APOE欠損マウス / 機能性食品 / 脂質異常症 / 微絨毛 / 腸管 / Caco-2細胞 / ABCG5/G8 / 高コレステロール血症 / 細胞内輸送 / 膜ホメオスタシス / ABCG8 / ABCG5 / NPC1L1 / コレステロール吸収制御 / エゼチミブ / 吸収 … More Except Principal Investigator プロモータ / PPARγ2 / PPARγ1 / 転写因子 / ノックアウトマウス / 脂質 / E4BP4 / DBP / C57Blackマウス / SV129マウス / 時計遺伝子 / CLOCK / BMAL1 / 脂肪誘導 / 胎盤巨細胞 / PPARγ1ノックアウトマウス / 新規スプライシングバリアント / PPARγ1プロモータ / ペルオキシソーム増殖因子活性化受容体 / 血小板巨核細胞 / 核内倍化 / 栄養膜巨大細胞 / 胎盤 / PPARγスプライシングバリアント / PPARγ / CRISPR-Cas9システム / 胎生致死 / 選択的スプライシングバリアント / ノックアウト(KO)マウス / PPARgamma / ノックアウト(KO)ホモマウス / 脂肪細胞分化誘導 / スプライシングバリアント / 腸管 / ViewRNA / 唾液腺 / 免疫染色 Less

Prevention of atheroscrelosis by a ow dose of plant sterols in micePrincipal Investigator
- Principal Investigator
  
  中野貴成
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Saitama Medical University
Prevention of atheroscrelosis by a low dose of plant sterols in micePrincipal Investigator
- Principal Investigator
  
  Nakano Takanari
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Saitama Medical University
The cause of PPARgamma1 exonC-specific knockout homozygous fetal death in homozygous mice
- Principal Investigator
  
  Inoue Ikuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Saitama Medical University
A Newly Integrated Model for Intestinal Cholesterol Absorption and Efflux Reappraises How Plant Sterol Intake Reduces Circulating Cholesterol LevelsPrincipal Investigator
- Principal Investigator
  
  NAKANO TAKANARI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Saitama Medical University
Discovery of Dwarfism Mouse Model by Deletion of PPAR gamma1 Specific Promoter.
- Principal Investigator
  
  INOUE Ikuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Saitama Medical University
胎生期に高発現するPPARγ3のマウス後期胚における局在と機能解析
- Principal Investigator
  
  TAKENAKA Yasuhiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Saitama Medical University
Proposed model that integrates cholesterol bidirectional flux in the small intestinePrincipal Investigator
- Principal Investigator
  
  Nakano Takanari
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Saitama Medical University

All 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Targeted disruption of Pparγ1 promotes trophoblast endoreplication in the murine placenta2020
- Author(s)
  Nakano Takanari、Aochi Hidekazu、Hirasaki Masataka、Takenaka Yasuhiro、Fujita Koji、Soma Hiroaki、Kamezawa Hajime、Koizumi Takahiro、Okuda Akihiko、Murakoshi Takayuki、Shimada Akira、Inoue Ikuo
- Journal Title
  
  bioRxiv
  
  Volume: 1 Pages: 1-29
- DOI
  10.1101/2020.05.28.120691
- Open Access
- Data Source
  KAKENHI-PROJECT-17K09866
[Journal Article] A Newly Integrated Model for Intestinal Cholesterol Absorption and Efflux Reappraises How Plant Sterol Intake Reduces Circulating Cholesterol Levels2019
- Author(s)
  Takanari Nakano, Ikuo Inoue, Takayuki Murakoshi
- Journal Title
  
  Nutrients
  
  Volume: 11 Issue: 2 Pages: 310-317
- DOI
  10.3390/nu11020310
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00864, KAKENHI-PROJECT-17K09866
[Journal Article] The annual rate of coronary artery calcification with combination therapy with a PCSK9 inhibitor and a statin is lower than that with statin monotherapy2018
- Author(s)
  Ikegami Yuichi、Inoue Ikuo、Inoue Kaiji、Shinoda Yuichi、Iida Shinichiro、Goto Seiichi、Nakano Takanari、Shimada Akira、Noda Mistuhiko
- Journal Title
  
  npj Aging and Mechanisms of Disease
  
  Volume: 4 Issue: 1 Pages: 1-8
- DOI
  10.1038/s41514-018-0026-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09866
[Journal Article] Evaluation of the effect of Teneligliptin on the transcriptional activity of PPARγ in cell-based assay.2018
- Author(s)
  Takenaka Y, Inoue I, Nakano T, Ikeda M, Kakinuma Y, Shimada A, Noda M.
- Journal Title
  
  J Nippon Med Sch
  
  Volume: (in press)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09866
[Journal Article] Luminal plant sterol promotes brush border membrane-to-lumen cholesterol efflux in the small intestine2018
- Author(s)
  Nakano Takanari、Inoue Ikuo、Takenaka Yasuhiro、Ikegami Yuichi、Kotani Norihiro、Shimada Akira、Noda Mitsuhiko、Murakoshi Takayuki
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 63 Issue: 2 Pages: 102-105
- DOI
  10.3164/jcbn.17-116
- NAID
  130007480039
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09866, KAKENHI-PROJECT-16K00864
[Journal Article] Plant sterol promotes brush border membrane-to-lumen cholesterol efflux in the small intestine2018
- Author(s)
  Nakano　T、Inoue　I、Takenaka　Y、Shimada　A、 Noda　M、Murakoshi　T
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: (in press)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09866
[Journal Article] The new molecular entity evolocumab, one kind of PCSK9 inhibitor, reduce plasma small size LDL-cholesterol levels by using a new standardized method of measuring LDL size.2017
- Author(s)
  Inoue I, Kubota R, Yanagi S, Akita M, Nakano T, Katayama S, Shimada A, Noda M.
- Journal Title
  
  Journal of Molecular and Integrative Physiology
  
  Volume: 7 Pages: 1-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09866
[Journal Article] Ezetimibe promotes brush bordermembrane-to-lumen cholesterol efflux in the small intestine.2016
- Author(s)
  Nakano T, Inoue I, et al.
- Journal Title
  
  PLoS ONE
  
  Volume: 11
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461367
[Journal Article] Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine2016
- Author(s)
  Nakano, T. Inoue, I. Takenaka, Y. Ono, H. Katayama, S. Awata, T. Murakoshi, T.
- Journal Title
  
  PLoS ONE
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25504013
[Journal Article] Ezetimibe promotes brush bordermembrane-to-lumen cholesterol efflux in the small intestine.2015
- Author(s)
  Nakano T, Inoue I, Takenaka Y,Ono H, Katayama S, Awata T, Murakoshi T.
- Journal Title
  
  PLoS One
  
  Volume: (in press)
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461367
[Journal Article] Identification of two nickel ion-induced genes, NI16 and PcGST1, in Paramecium caudatum.2014
- Author(s)
  Yasuhiro Takenaka, Nobuyuki Haga, Ikuo Inoue, Takanari Nakano, Masaaki Ikeda, Sgigehiro Katayama, Takuwa Awata.
- Journal Title
  
  Eukaryotic Cell
  
  Volume: 13 Pages: 1181-90
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461367
[Journal Article] Identification of two nickel ion-induced genes, NCI16 and PcGST1, in Paramecium caudatum2014
- Author(s)
  Takenaka, Y., Haga, N., Inoue, I., Nakano, T., Ikeda, M., Katayama, S., Awata
- Journal Title
  
  Eukaryotic Cell
  
  Volume: 13 Issue: 9 Pages: 1181-1190
- DOI
  10.1128/ec.00112-14
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460299
[Journal Article] A Novel Splicing Variant of Peroxisome Proliferator-Activated Receptor-γ (Pparγ1sv) Cooperatively Regulates Adipocyte Differentiation with Pparγ2.2013
- Author(s)
  Takenaka Y, Inoue I, Nakano T, Shinoda Y, Ikeda M, Awata T, Katayama S
- Journal Title
  
  PloS ONE
  
  Volume: 8 Issue: 6 Pages: e65583-e65583
- DOI
  10.1371/journal.pone.0065583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590645, KAKENHI-PROJECT-25460299
[Presentation] 腸上皮微絨毛におけるコレステロール両極性フラックスとトランスポーター2018
- Author(s)
  中野貴成, 井上郁夫, 竹中康浩, 小谷典弘, 島田朗, 野田光彦, 村越隆之
- Organizer
  第3回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-16K00864
[Presentation] 植物ステロールは腸管経由コレステロール逆輸送を促進する2018
- Author(s)
  中野貴成, 井上郁夫, 竹中康浩, 池上裕一, 小谷典弘, 島田朗, 野田光彦, 村越隆之
- Organizer
  第61回糖尿病学会
- Data Source
  KAKENHI-PROJECT-16K00864
[Presentation] 腸上皮微絨毛におけるコレステロール両極性フラックスとトランスポーター2018
- Author(s)
  中野貴成, 井上郁夫, 竹中康浩, 小谷典弘, 島田朗, 野田光彦, 村越隆之
- Organizer
  第3回トランスポーター研究会関東部会(千葉)
- Data Source
  KAKENHI-PROJECT-17K09866
[Presentation] PCSK9阻害薬の小型LDL、超小型LDL低下作用.2017
- Author(s)
  池上裕一、後藤誠一、井上郁夫、島田　朗、野田光彦、久保田　亮、穐田真澄、中野貴成、柳　捷凡
- Organizer
  第49回日本動脈硬化学会
- Data Source
  KAKENHI-PROJECT-17K09866
[Presentation] Ezetimibe Promotes Brush Border Membrane (BBM)-to-Lumen Cholesterol Efflux in the Small Intestine2017
- Author(s)
  Takanari Nakano,Ikuo Inoue,Yasuhiro Takenaka,Hiraku Ono, Shigehiro Katayama,Takuya Awata,Takayuki Murakoshi
- Organizer
  生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K00864
[Presentation] 一元的システムによる小腸コレステロール吸収- 排泄制御機構2015
- Author(s)
  中野貴成, 井上郁夫, 竹中康浩, 片山茂裕, 粟田卓也, 村越隆之
- Organizer
  第47回日本動脈硬化学会総会・学術集会（宮城県仙台市）
- Place of Presentation
  仙台国際センター・新展示施設
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-25504013
[Presentation] PPARγの転写制御活性にテネリグリプチンが及ぼす効果2014
- Author(s)
  竹中康浩、井上郁夫、中野貴成、池田正明、栗原進、小野啓、後藤誠一、片山茂裕、粟田卓也
- Organizer
  第４６回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-10
- Data Source
  KAKENHI-PROJECT-25460299
[Presentation] マウスPPARγスプライシングバリアントのポジティブフィードバック制御機構の解析2014
- Author(s)
  竹中康浩、井上郁夫、中野貴成、池田正明、栗原進、小野啓、後藤誠一、片山茂裕、粟田卓也
- Organizer
  第５７回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-25460299
[Presentation] ゾウリムシニッケル誘導遺伝子NCI16とPcGST1の単離と発現量解析および発現制御に関する研究2014
- Author(s)
  竹中康浩、芳賀信幸、井上郁夫、中野貴成、池田正明、粟田卓也、片山茂裕
- Organizer
  第３７回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-25460299
[Presentation] マウス新規PPARγスプライシングバリアント（Pparγ1sv）の脂肪細胞分化誘導における発現と機能解析2013
- Author(s)
  竹中康浩、井上郁夫、中野貴成、池田正明、栗原進、後藤誠一、片山茂裕、粟田卓也
- Organizer
  第３１回日本肥満症治療学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460299
[Presentation] 核内受容体PPARγの新規スプライシングバリアント(Pparγ1sv)の転写制御機構の解析2013
- Author(s)
  竹中康浩、井上郁夫、中野貴成、池田正明、片山茂裕、粟田卓也
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25460299
[Presentation] マウス17日胚における新規PPARγスプライシングバリアント(Pparγ1sv)の発現2013
- Author(s)
  竹中康浩、井上郁夫、中野貴成、池田正明、片山茂裕、粟田卓也
- Organizer
  第８６回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25460299
[Presentation] マウスPPARγスプライシングバリアントのマウス後期胚における局在と機能解析2013
- Author(s)
  竹中康浩、井上郁夫、中野貴成、池田正明、篠田雄一、片山茂裕、粟田卓也
- Organizer
  第５６回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25460299
[Presentation] 腸管吸収におけるステロール種選別とABCG5/G8の役割
- Author(s)
  中野貴成、井上郁夫,竹中康浩,片山茂裕, 粟田卓也, 村越隆之
- Organizer
  第46回日本動脈硬化学会総会・学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25504013
[Presentation] 一元的システムによる小腸コレステロール吸収-排泄制御機構
- Author(s)
  中野貴成、井上郁夫,竹中康浩,片山茂裕, 粟田卓也, 村越隆之
- Organizer
  第47回日本動脈硬化学会総会・学術集会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2015-07-09 – 2015-07-10
- Data Source
  KAKENHI-PROJECT-25504013
[Presentation] マウスPPARγスプライシングバリアントのポジティブフィードバック制御機構の解析
- Author(s)
  竹中康浩、井上郁夫、中野貴成、池田正明、栗原進、小野啓、後藤誠一、片山茂裕、粟田卓也.
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場、大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26461367
[Presentation] ABCG5/G8 heterodimer confers 'Safety valve' for rate-limiting dietary sterol absorption in the small intestine
- Author(s)
  中野貴成、井上郁夫,竹中康浩,片山茂裕, 粟田卓也, 村越隆之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25504013

1. INOUE Ikuo (60232526)

# of Collaborated Projects: 5 results

# of Collaborated Products: 23 results
2. TAKENAKA Yasuhiro (20586789)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
3. 青地英和 (40646478)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 平崎正孝 (10522154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 池田正明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakano Takanari 中野 貴成

Research Projects

Research Products

Co-Researchers

Prevention of atheroscrelosis by a ow dose of plant sterols in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prevention of atheroscrelosis by a low dose of plant sterols in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The cause of PPARgamma1 exonC-specific knockout homozygous fetal death in homozygous mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Newly Integrated Model for Intestinal Cholesterol Absorption and Efflux Reappraises How Plant Sterol Intake Reduces Circulating Cholesterol LevelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Discovery of Dwarfism Mouse Model by Deletion of PPAR gamma1 Specific Promoter.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胎生期に高発現するPPARγ3のマウス後期胚における局在と機能解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proposed model that integrates cholesterol bidirectional flux in the small intestinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Targeted disruption of Pparγ1 promotes trophoblast endoreplication in the murine placenta2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Newly Integrated Model for Intestinal Cholesterol Absorption and Efflux Reappraises How Plant Sterol Intake Reduces Circulating Cholesterol Levels2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The annual rate of coronary artery calcification with combination therapy with a PCSK9 inhibitor and a statin is lower than that with statin monotherapy2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of the effect of Teneligliptin on the transcriptional activity of PPARγ in cell-based assay.2018

Author(s)

Journal Title

Data Source

[Journal Article] Luminal plant sterol promotes brush border membrane-to-lumen cholesterol efflux in the small intestine2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Plant sterol promotes brush border membrane-to-lumen cholesterol efflux in the small intestine2018

Author(s)

Journal Title

Data Source

[Journal Article] The new molecular entity evolocumab, one kind of PCSK9 inhibitor, reduce plasma small size LDL-cholesterol levels by using a new standardized method of measuring LDL size.2017

Author(s)

Journal Title

Nakano Takanari 中野貴成