Takaku Tomoiku 高久智生

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TAKAKU Tomoiku 高久智生

高久智生タカクトモイク

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Researcher Number	20408256
Other IDs
Affiliation (Current)	2025: 埼玉医科大学, 医学部, 教授 2025: 順天堂大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 医学部, 准教授 2011 – 2014: 順天堂大学, 医学部, 准教授 2007: 東京医科大学, 医学部, 臨床研究医 2005 – 2006: 東京医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Bioinformatics/Life informatics / Hematology
Keywords	Principal Investigator 治療抵抗性 / チロシンキナーゼ阻害薬 / チロシンキナーゼ阻害薬治療抵抗性 / DRP1 / ミトコンドリアの断片化 / シングルセルアナリシス / ゴーストサイトメトリー / ミトコンドリア / 白血病幹細胞 / 慢性骨髄性白血病 … More / 骨髄3次元構造 / 造血幹細胞 / サーカディアンリズム / 骨髄内神経ニッチ / 共焦点顕微鏡 / Neuron niche / Circadian rhythm / Hematopoietic niche … More Except Principal Investigator logical operation / viral infection / absolute quantification / gene expression analysis / DNA computer / DNAマイクロアレイ / 論理演算 / ウイルス感染症 / 絶対定量 / 遺伝子発現解析 / DNAコンピューター / apoptosis / FOXO3a / PP2A / sodium selenate / ATRA / APL / 活性酸素種 / FTY720 / ATRA耐性 / 全トランスレチノイン酸(ATRA) / 急性前骨髄球性白血病(APL) / プロテインホスファターゼ2A / FOXO3A Less

Development of novel treatment strategy for TKI resistant chronic myeloid leukemia cell.Principal Investigator
- Principal Investigator
  
  Takaku Tomoiku
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Development of the new treatment strategy of ATRA-resistant APL using PP2A-FOXO3A activation pathway
- Principal Investigator
  
  KOMATSU NORIO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Analysis of hematopoietic regulation system by circadian rhythmPrincipal Investigator
- Principal Investigator
  
  TOMOIKU Takaku
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Applications of molecular nanotechnology for human disease using DNA-encode based gene expression analysis
- Principal Investigator
  
  OHYASHIKI Junko
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  Tokyo Medical University

All 2023 2022 2012 2007 2006 2005

All Journal Article Presentation

[Journal Article] Artificial Intelligence Enables the Label-Free Identification of Chronic Myeloid Leukemia Cells with Mitochondrial Morphological Alterations2023
- Author(s)
  Suzuki Kohjin、Watanabe Naoki、Torii Satoru、Arakawa Satoko、Ochi Kiyosumi、Tsuchiya Shun、Yamada Kazuhiro、Kawamura Yoko、Ota Sadao、Komatsu Norio、Shimizu Shigeomi、Ando Miki、Takaku Tomoiku
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.07.26.550632
- Open Access
- Data Source
  KAKENHI-PROJECT-21K08406
[Journal Article] 骨髄三次元構造の再構築とその解析2012
- Author(s)
  高久智生
- Journal Title
  
  週刊　医学のあゆみ
  
  Volume: 242 Pages: 741-746
- Data Source
  KAKENHI-PROJECT-23591408
[Journal Article] Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells2007
- Author(s)
  Hamamura, RS., Ohyashiki, JH., Kurashina, R., Kobayashi, C., Zhang, Y., Takaku, T., Ohyashiki, K
- Journal Title
  
  Br J Cancer 97(8)
  
  Pages: 1099-105
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300095
[Journal Article] Transcriptional profiling of Epstein-Barr virus(EBV) genes and host cellular genes in nasal NK/T-cell lymphoma and chronic active EBV infection2006
- Author(s)
  Zhang, Y., Ohyashiki, JH., Takaku, T., Shimizu, N., Ohyashiki, K
- Journal Title
  
  Br J Cancer 94(4)
  
  Pages: 599-608
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300095
[Journal Article] Estimating immunoregulatory gene networks in human herpesvirus type 6-infected T cells.2005
- Author(s)
  Takaku T. et al.
- Journal Title
  
  Biochem Biophys Res Commun. 336(2)
  
  Pages: 469-477
- Data Source
  KAKENHI-PROJECT-17300095
[Journal Article] Estimating immunoregulatory gene networks in human herpesvirus type 6-infected T cells2005
- Author(s)
  Takaku T
- Journal Title
  
  Biochem Biophys Res Commun. 336
  
  Pages: 469-477
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300095
[Journal Article] Estimating immunoregulatory gene networks in human herpesvirus type 6-infected T cells2005
- Author(s)
  Takaku, T., Ohyashiki, JH., Zhang, Y., Ohyashiki, K
- Journal Title
  
  Biochem Biophys Res Commun 336(2)
  
  Pages: 469-77
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300095
[Presentation] AI-Driven “Ghost Cytometry” Enables Label-Free Identification of Leukemia Cells Through Mitochondrial Alterations2023
- Author(s)
  Kohjin Suzuki, Tomoiku Takaku
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08406
[Presentation] MAPK活性化とDrp1リン酸化により誘導されるCML細胞のAI検出可能なミトコンドリアの変化2023
- Author(s)
  鈴木行人,高久智生
- Organizer
  日本血液学会学術集会総会
- Data Source
  KAKENHI-PROJECT-21K08406
[Presentation] Artificial Intelligence-Driven “Ghost Cytometry” Enables Label-Free Identification of Chronic Myeloid Leukemia Cells Through Mitochondrial Morphological Alterations2023
- Author(s)
  Kohjin Suzuki, Tomoiku Takaku
- Organizer
  25th ESH iCMLf John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08406
[Presentation] CML細胞における細胞内小器官の機能および形態分析2022
- Author(s)
  高久智生
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08406
[Presentation] A novel Quanta-DNA Chip for gene expression analysis : DNA computing using the DNA Coded Number(DCN) methods2005
- Author(s)
  Ohyashiki, JH., Nakajima, T., Makino, T., Takaku, T., Ohyashiki, K., Suyama, A
- Organizer
  96th Annual Meeting forAmerican Association for Cancer Research, April
- Place of Presentation
  Anaheim, USA
- Year and Date
  2005-04-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300095

1. OHYASHIKI Junko (20191950)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. KOMATSU NORIO (50186798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YAMADA Seiko (30408257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 荒木真理人 (80613843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Takaku Tomoiku 高久 智生

TAKAKU Tomoiku 高久 智生

高久 智生 タカク トモイク

Research Projects

Research Products

Co-Researchers

Development of novel treatment strategy for TKI resistant chronic myeloid leukemia cell.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the new treatment strategy of ATRA-resistant APL using PP2A-FOXO3A activation pathway

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of hematopoietic regulation system by circadian rhythmPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Applications of molecular nanotechnology for human disease using DNA-encode based gene expression analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Artificial Intelligence Enables the Label-Free Identification of Chronic Myeloid Leukemia Cells with Mitochondrial Morphological Alterations2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 骨髄三次元構造の再構築とその解析2012

Author(s)

Journal Title

Data Source

[Journal Article] Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Transcriptional profiling of Epstein-Barr virus(EBV) genes and host cellular genes in nasal NK/T-cell lymphoma and chronic active EBV infection2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Estimating immunoregulatory gene networks in human herpesvirus type 6-infected T cells.2005

Author(s)

Journal Title

Data Source

[Journal Article] Estimating immunoregulatory gene networks in human herpesvirus type 6-infected T cells2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Estimating immunoregulatory gene networks in human herpesvirus type 6-infected T cells2005

Author(s)

Journal Title

Description

Data Source

[Presentation] AI-Driven “Ghost Cytometry” Enables Label-Free Identification of Leukemia Cells Through Mitochondrial Alterations2023

Author(s)

Organizer

Data Source

[Presentation] MAPK活性化とDrp1リン酸化により誘導されるCML細胞のAI検出可能なミトコンドリアの変化2023

Author(s)

Organizer

Data Source

[Presentation] Artificial Intelligence-Driven “Ghost Cytometry” Enables Label-Free Identification of Chronic Myeloid Leukemia Cells Through Mitochondrial Morphological Alterations2023

Author(s)

Organizer

Data Source

[Presentation] CML細胞における細胞内小器官の機能および形態分析2022

Author(s)

Organizer

Data Source

[Presentation] A novel Quanta-DNA Chip for gene expression analysis : DNA computing using the DNA Coded Number(DCN) methods2005

Takaku Tomoiku 高久智生

TAKAKU Tomoiku 高久智生

高久智生タカクトモイク