Takahashi Kou 高橋弘

… Alternative Names

TAKAHASHI Kou 高橋弘

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Researcher Number	20415582
Other IDs
External Links
Affiliation (Current)	2025: 高知大学, 教育研究部医療学系基礎医学部門, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 高知大学, 教育研究部医療学系基礎医学部門, 准教授 2017 – 2018: 高知大学, 教育研究部医療学系基礎医学部門, 助教 2011: 独立行政法人国立精神・神経医療研究センター, 研究員 2010: 独立行政法人国立精神・神経医療研究センター, 精神保健研究所・精神薬理研究部, 協力研究員 2010: 独立行政法人国立精神・神経医療研究センター, 精神保健研究所・精神薬理研究部, 流動研究員 … More 2009: National Center of Neurology and Psychiatry, 老人精神保健部, 外来研究員 2009: National Center of Neurology and Psychiatry, 精神保健研究所老人精神保健部, 外来研究員 2008 – 2009: National Center of Neurology and Psychiatry, 精神保健研究所・老人精神保健部, 外来研究員 2006 – 2008: 国立精神・神経センター, 精神保健研究所・老人精神保健部, 研究員 2007: National Center of Neurology and Psychiatry, 精神保健研究所老人精神保健部, 研究員 2007: NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY, DIVISION OF PSYCHOGERIATRICS, Researcher Less
Review Section/Research Field	Principal Investigator Psychiatric science / Basic Section 52030:Psychiatry-related Except Principal Investigator Psychiatric science / Basic Section 52030:Psychiatry-related / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator アストロサイト / グリア / うつ病 / ストレス / グルタミン酸トランスポーター / 抗うつ薬 / 興奮毒性 / 全脳解析 / グルタミン酸作動性ニューロン / 神経活動 … More / 精神薬理学 / グルタミン酸受容体 / EAAT2 / うつ症状 / プロモーターアッセイ / 発現調節 / Ndrg2 / グルココルチコイド / western blot 法 / real time PCR 法 / western blot法 / real time PCR法 / microarray / 電気けいれん / 分化 / 発生 / 神経幹細胞 / 精神薬理 … More Except Principal Investigator 抗うつ薬 / 神経新生 / 情動行動 / うつ病 / 遺伝子発現 / 網羅的探索 / 転写因子 / 精神薬理学 / 自閉スペクトラム症 / 視床下部 / 社会行動 / バソプレシン / ヘモプレシン / DIFFERENTIAL CLONING / NEUROGENESIS / ECT / ANTIDEPRESSANT / 小胞体 / 経頭蓋的磁気刺激 / 電気けいれん / ELECTROCONVULSIVE TREATMENT / 遺伝子 / モデル動物 / 神経可塑的変化 / 行動薬理 / 大脳皮質初代培養神経細胞 Less

ヘモグロビン由来マリファナ様物質の脳内作用機序と社会性障害治療効果
- Principal Investigator
  
  田中健二朗
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kochi University
Investigating the neural mechanisms underlying depressive symptoms associated with the reduced expression of the astrocytic glutamate transporter.Principal Investigator
- Principal Investigator
  
  Takahashi Kou
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kochi University
Drug discovery research for novel anti-stress and antidepressant drugs targeting glutamate transportersPrincipal Investigator
- Principal Investigator
  
  Takahashi Kou
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Kochi University
Gene expression analysis in ventral and dorsal hippocampal dentate gyrus after 4 weeks treatment with sertraline
- Principal Investigator
  
  YAMADA Mitsuhiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Center of Neurology and Psychiatry
Prg1, regulated by MATH2, is an important factor for survival of neurons derived from neural stem cells
- Principal Investigator
  
  YAMADA Misa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  National Center of Neurology and Psychiatry
グルココルチコイドによる抗うつ薬関連遺伝子Ndrg2発現誘導のシグナル解明Principal Investigator
- Principal Investigator
  
  高橋弘
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  National Center of Neurology and Psychiatry
An antidepressant related transcription factor Math2 regulates Prg1 expression and induces neurite differentiation.
- Principal Investigator
  
  YAMADA Misa
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  National Center of Neurology and Psychiatry
Expression analysis of N-Myc downstream regulated gene 2 (Ndrg2) using the embryonic spinal cord and the adult brainPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Kou
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  National Center of Neurology and Psychiatry
SCREENING FOR ANTIDEPRESSANT RELATED GENES RELATED TO NEUROGENESIS
- Principal Investigator
  
  YAMADA Mitsuhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  National Center of Neurology and Psychiatry

All 2024 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book

[Book] Breathing, Feeding, and Neuroprotection.2006
- Author(s)
  Yamada M, Takahashi K, Kurahashi C, Yamada M, Honda K
- Publisher
  Springer-verlag, Tokyo
- Data Source
  KAKENHI-PROJECT-18591323
[Book] Breathing, Feeding, and Neuroprotection.2006
- Author(s)
  Yamada M, Takahashi K, Kurahashi C, Yamada M, Honda K
- Publisher
  Springer-Verlag, Tokyo
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591323
[Journal Article] Neuroserpin is expressed in early stage of neurogenesis in adult rat hippocampus.2010
- Author(s)
  Yamada, M., Takahashi, K., Ukai, W, Hashimoto, E., Saito, T., Yamada M.
- Journal Title
  
  Neuroreport 21
  
  Pages: 138-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790849
[Journal Article] Neuroserpin is expressed in early stage of neurogenesis in adult rat hippocampus.2010
- Author(s)
  Yamada, M., Takahashi, K., Ukai, W., Hashimoto, E., Saito, T., Yamada M.
- Journal Title
  
  Neuroreport 21(2)
  
  Pages: 138-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790849
[Journal Article] Induction of the transcription factor Math2 and its target gene Prg1 after chronic treatment with selective serotonin reuptake inhibitors in rat brain.2009
- Author(s)
  Yamada, M., Shida, Y., Takahashi, K., Yamada M.
- Journal Title
  
  J. Mental Health 55
  
  Pages: 103-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790849
[Journal Article] Induction of the transcription factor Math2 and its target gene Prg1 after chronic treatment with selective serotonin reuptake inhibitors in rat brain2009
- Author(s)
  Yamada, M., Shida, Y., Takahashi, K., Yamada M.
- Journal Title
  
  J.Mental Health 55
  
  Pages: 103-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591390
[Journal Article] Induction of the transcription factor Math2 and its target gene Prg1 after chronic treatment with selective serotonin reuptake inhibitors in rat brain.2009
- Author(s)
  Yamada, M., Shida, Y., Takahashi, K., Yamada M.
- Journal Title
  
  J. Mental Health 55
  
  Pages: 103-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591390
[Journal Article] Induction of the transcription factor Math2 and its target gene Prg l after chronic treatment with selective serotonin reuptake inhibitors in ratbrain.2009
- Author(s)
  Yamada, M., Shida, Y., Takahashi, K., Yamada M.
- Journal Title
  
  J.Mental Health 55
  
  Pages: 103-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790849
[Journal Article] Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway.2008
- Author(s)
  Maruyama, Y., Yamada, M., Takahashi, K., Yamada, M.
- Journal Title
  
  Biochem. Biophys. Res. Comm. 374
  
  Pages: 737-741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790849
[Journal Article] Prg1 is regulated by the basic helix-loop-helix transcription factor Math2.2008
- Author(s)
  Yamada, M., Shida, Y., Takahashi, K., Tanioka, T., Nakano, Y., Tobe, T., Yamada, M.
- Journal Title
  
  J. Neurochem 106
  
  Pages: 2375-2384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591390
[Journal Article] Gene expression profiling reveals complex changes in the olfactory bulbectomy model of depression after chronic treatment with antidepressants2008
- Author(s)
  Takahashi, K
- Journal Title
  
  J Pharmacol. Sci. 108
  
  Pages: 320-334
- NAID
  10024593145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790849
[Journal Article] Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S, 5R)-2, 5-di methyl-4-(2-propenyl)-1-pi perazinyl]-(3-methoxyphenyl)methyl]-N, N -diethylbenzamide] in an olfactory bulbectomized rat model.2008
- Author(s)
  Saitoh, A., Yamada, M., Yamada, M., Takahashi K., Yamaguchi, K., Murasawa, H., Nakatani, A., Tatsumi, Y., Hirose, N., Kamei, J.
- Journal Title
  
  Brain research 1208
  
  Pages: 160-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790849
[Journal Article] Prg1 is regulated by the basic helix-loop-helix transcription factor Math22008
- Author(s)
  Yamada M, Shida Y, Takahashi K, Tanioka T, Nakano Y, Tobe T, Yamada M.
- Journal Title
  
  J. Neurochem 106
  
  Pages: 2375-2384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591390
[Journal Article] Prg1 is regulated by the basic helix-loop-helix transcription factor Math2.2008
- Author(s)
  Yamada, M., Shida Y., Takahashi, K., Tanioka T., Nakano Y., Tobe T., Yamada, M.
- Journal Title
  
  J Neurochem 106(6)
  
  Pages: 2375-2384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790849
[Journal Article] Gene expression profiling reveals complex changes in the olfactory bulbectomy model of depression after chronic treatment with antidepressants.2008
- Author(s)
  Takahashi, K., Saitoh, A., Yamada, M., Maruyama, Y., Hirose, N., Kamei, J., Yamada, M.
- Journal Title
  
  J Pharmacol. Sci. 108(3)
  
  Pages: 320-334
- NAID
  10024593145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790849
[Journal Article] The expression of synaptic vesicle proteins after chronic antidepressant treatment in rat brain.2006
- Author(s)
  Yamada M, Takahashi K, Kurahashi C, Yamada M, Honda K.
- Journal Title
  
  Breathing, Feeding, and Neuroprotection.
  
  Pages: 82-87
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591323
[Journal Article] 山田光彦、山田美佐、高橋弘、丸山良亮 : 遺伝子から探る新規抗うつ薬の開発2006
- Author(s)
  山田光彦, 山田美佐, 高橋弘, 丸山良亮
- Journal Title
  
  日本薬理学雑誌 128
  
  Pages: 19-22
- Data Source
  KAKENHI-PROJECT-18591323
[Presentation] ヘモプレシンによる社会的アプローチ行動の減少と視床下部バソプレシン産生ニューロンの活動抑制2024
- Author(s)
  田中健二朗, 大迫洋治, 高橋弘, 日高千晴, 中根裕信
- Organizer
  第129回日本解剖学会総会
- Data Source
  KAKENHI-PROJECT-22K07563
[Presentation] An antidepressant related transcription factor Math2 regulates Prg1 expression and involves in neurite differentiation.2009
- Author(s)
  Yamada, M., Yamada, M., Shida Y., Takahashi, K., Tanioka T., Nakano Y., Tobe T.
- Organizer
  The 1st Meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  Kyoto International Conference Center
- Data Source
  KAKENHI-PROJECT-19790849
[Presentation] A glutamate release inhibitor rapidly attenuates hyperemotional responses in OBX rats.2009
- Author(s)
  Inagaki, M., Takahashi, K., Saitoh, A., Yamada, M., Iwai, T., Nakaani, A., Murasawa, H., Yoshida, M., Yamaguchi, K., Yamada, M.
- Organizer
  The 1st Meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  Kyoto International Conference Center
- Data Source
  KAKENHI-PROJECT-19790849
[Presentation] Chronic treatment with a selective opioid-delta agonist SNC80 affects the expression of excitatory amino-acid transporter genes in frontal cortex of olfactory bulbectomized rat.2009
- Author(s)
  Saitoh, A., Yamada, M., Takahashi, K., Iwai, T., Inagaki, M., Yamada, M.
- Organizer
  The 1st Meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  Kyoto International Conference Center
- Data Source
  KAKENHI-PROJECT-19790849
[Presentation] An antidepressant related transcription factor Math2 regulates Prgl expression and involves in neurite differentiation.2009
- Author(s)
  Yamada, M., Yamada, M., Shida Y., Takahashi, K., Tanioka T., Nakano Y., Tobe T.
- Organizer
  The 1st Meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-19790849
[Presentation] A glutamate release inhibitor rapidly attenuates hyperemotional responses in OBX rats.2009
- Author(s)
  Inagaki, M., Takahashi, K., Saitoh, A., Yamada, M., Iwai, T., Nakaani, A., Murasawa, H., Yoshida, M., Yamaguchi, K., Yamada, M.
- Organizer
  The 1st Meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-19790849
[Presentation] 抗うつ薬の作用メカニズムに関わる転写因子ADRG701が制御する下流遺伝子の探索2007
- Author(s)
  志田美子, 高橋弘, 山田美佐, 中野泰子, 戸部敞, 山田光彦
- Organizer
  第30回日本分子生物学会年会, 第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜, 神奈川
- Data Source
  KAKENHI-PROJECT-19591390
[Presentation] 抗うつ薬の作用メカニズムに関わる転写因子が制御する下流遺伝子の探索2007
- Author(s)
  志田美子, 高橋弘, 山田美佐, 中野泰子, 戸部敞, 山田光彦
- Organizer
  第30回日本分子生物学会年会, 第80回日本生化学会大会合同大会BMB2007
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18591323
[Presentation] The RING finger domain of Kf-1 is required for ubiquitin ligase activity and subcellular redistribution.2007
- Author(s)
  丸山良亮, 山田美佐, 高橋弘, 山田光彦
- Organizer
  BMB2007
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790849
[Presentation] The RING finger domain of Kf-l is required for ubiquitin ligase activity and subcellular redistribution2007
- Author(s)
  丸山良亮, 山田美佐, 高橋弘, 山田光彦
- Organizer
  BMB2007
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19790849
[Presentation] 抗うっ薬の作用メカニズムに関わる転写因子ADRG701が制御する下流遺伝子の探索2007
- Author(s)
  志田美子, 高橋弘, 山田美佐, 中野泰子, 戸部激, 山田光彦
- Organizer
  BMB2007
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19790849
[Presentation] 抗うつ薬の作用メカニズムに関わる転写因子ADRG701が制御する下流遺伝子の探索2007
- Author(s)
  志田美子, 高橋弘, 山田美佐, 中野泰子, 戸部敞山田光彦
- Organizer
  BMB2007
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790849
[Presentation] 抗うつ薬の作用メカニズムに関わる転写因子が制御する下流遺伝子の探索2007
- Author(s)
  志田美子, 高橋弘, 山田美佐, 中野泰子, 戸部敞, 山田光彦
- Organizer
  第30回日本分子生物学会年会, 第80回日本生化学会大会合同大会BMB2007
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591390
[Presentation] An antidepressant related transcription factor Math2 regulates Prg1 expression and induces neurite differentiation.
- Author(s)
  Yamada, M., Yamada, M., Shida, Y., Takahashi, K., Tanioka, T., Nakano, Y, Tobe, T.
- Organizer
  The 1st Meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  京都国際会議場Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-19591390

1. YAMADA Misa (10384182)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
2. YAMADA Mitsuhiko (60240040)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
3. MARUYAMA Yoshiaki (70421831)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. SAITOH Akiyoshi (00366832)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 岩井孝志 (90339135)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 由利和也 (10220534)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 田中健二朗 (30552260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Takahashi Kou 高橋 弘

TAKAHASHI Kou 高橋 弘

Research Projects

Research Products

Co-Researchers

ヘモグロビン由来マリファナ様物質の脳内作用機序と社会性障害治療効果

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigating the neural mechanisms underlying depressive symptoms associated with the reduced expression of the astrocytic glutamate transporter.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery research for novel anti-stress and antidepressant drugs targeting glutamate transportersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene expression analysis in ventral and dorsal hippocampal dentate gyrus after 4 weeks treatment with sertraline

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prg1, regulated by MATH2, is an important factor for survival of neurons derived from neural stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

グルココルチコイドによる抗うつ薬関連遺伝子Ndrg2発現誘導のシグナル解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An antidepressant related transcription factor Math2 regulates Prg1 expression and induces neurite differentiation.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression analysis of N-Myc downstream regulated gene 2 (Ndrg2) using the embryonic spinal cord and the adult brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

SCREENING FOR ANTIDEPRESSANT RELATED GENES RELATED TO NEUROGENESIS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Breathing, Feeding, and Neuroprotection.2006

Author(s)

Publisher

Data Source

[Book] Breathing, Feeding, and Neuroprotection.2006

Author(s)

Publisher

Description

Data Source

[Journal Article] Neuroserpin is expressed in early stage of neurogenesis in adult rat hippocampus.2010

Author(s)

Journal Title

Data Source

[Journal Article] Neuroserpin is expressed in early stage of neurogenesis in adult rat hippocampus.2010

Author(s)

Journal Title

Data Source

[Journal Article] Induction of the transcription factor Math2 and its target gene Prg1 after chronic treatment with selective serotonin reuptake inhibitors in rat brain.2009

Author(s)

Journal Title

Data Source

Takahashi Kou 高橋弘

TAKAHASHI Kou 高橋弘