Fujimura Masatake 藤村成剛

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FUJIMURA Masatake 藤村成剛

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Researcher Number	20416564
Other IDs
Affiliation (Current)	2025: 国立水俣病総合研究センター, その他部局等, 部長
Affiliation (based on the past Project Information) *help	2019 – 2024: 国立水俣病総合研究センター, その他部局等, 部長 2015 – 2016: 国立水俣病総合研究センター, その他部局等, 室長 2009 – 2016: National Institute for Minamata Disease, 基礎研究部, 室長 2013 – 2014: 国立水俣病総合研究センター, その他部局等, その他 2013: 国立水俣病総合研究センター, 基礎研究部・病理室, 室長 2012 – 2013: 国立水俣病総合研究センター, 基礎研究部・病理室, 室長 2008: National Institute for Minamata Disease, 基礎研究部・病理室, 室長
Review Section/Research Field	Principal Investigator Environmental pharmacy / Basic Section 64010:Environmental load and risk assessment-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Environmental and hygienic pharmacy Except Principal Investigator Pathological medical chemistry / Neurology / Risk sciences of radiation/Chemicals
Keywords	Principal Investigator メチル水銀 / 神経機能障害 / 中毒学 / 水俣病 / miRNA / エクソソーム / ポリチオール化 / バイオマーカー / 振動刺激 / 筋線維 … More / 神経軸索 / 振動刺激処置 / ROCK阻害剤 / 神経障害性疼痛 / 筋機能障害 / シナプス蛋白 / 神経突起 / 小脳 / 神経症状 / 胎児期曝露 / 低濃度メチル水銀 / 薬学 / 環境系薬学 / 選択的神経細胞障害 / フランス / 国際情報交換 / 小脳顆粒細胞 / マイクロダイセクション / 薬理学 / 脳神経疾患 / 再生医学 / 環境 / ローキナーゼ阻害薬 / 環境毒 … More Except Principal Investigator ストレス蛋白質 / GAS5 / 早期終止コドン / Snhg1 / 蛋白質翻訳 / mTOR pathway / 小胞体ストレスプレコンディショニング / 早期終止コドン (PTC) / eIF2α リン酸化 / Snhg1 mRNA / 蛋白質翻訳抑制 / 早期終止コドン(PTC) / NMD抑制 / eIF2αリン酸化 / mRNA監視機構(NMD) / 環境ストレス / ラット / 小脳 / VEGF / 血液脳関門 / 血管内皮細胞増殖因子 / メチル水銀中毒 / 水俣病 / 芳香族炭化水素受容体 / 成長遅滞 / 成長ホルモン / 黄体形成ホルモン / 育児破綻 / プロラクチン / 性未成熟 / 性ステロイド / ダイオキシン Less

Development of a biomarker that can objectively determine differences in individual susceptibility to methylmercury poisoningPrincipal Investigator
- Principal Investigator
  
  藤村成剛
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 64010:Environmental load and risk assessment-related
- Research Institution
  National Institute for Minamata Disease
Experimental research on regenerative treatment of axon and muscle fiber for nerve and muscle dysfunction by methylmercuryPrincipal Investigator
- Principal Investigator
  
  Fujimura Masatake
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Institute for Minamata Disease
Research on inciting factor of neurological symptoms following low dose methylmercury exposure in fetal periodPrincipal Investigator
- Principal Investigator
  
  Fujimura Masatake
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  National Institute for Minamata Disease
Research on environmental stresses-induced change in nonsense-mediated mRNA decay (NMD) activity and its effect on pathological conditions
- Principal Investigator
  
  Usuki Fusako
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Institute for Minamata Disease
環境汚染物質による性未成熟のインプリンティングと育児破綻の分子機構
- Principal Investigator
  
  山田英之
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyushu University
Analysis of vascular endothelial growth factor as novel therapeutic target for methylmercury poisoning
- Principal Investigator
  
  SHIMOHATA Takayoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Experimental research on selective neuronal damage by methylmercury using microdissection methodPrincipal Investigator
- Principal Investigator
  
  FUJIMURA Masatake
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  National Institute for Minamata Disease
Experimental study on effect of Rho kinase inhibitors against neurological impairment by environmental toxinsPrincipal Investigator
- Principal Investigator
  
  FUJIMURA Masatake
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  National Institute for Minamata Disease

[Book] Handbook of Neurotoxicity2021
- Author(s)
  Fujimura M, Usuki F
- Total Pages
  16
- Publisher
  Springer, Cham
- ISBN
  9783030715199
- Data Source
  KAKENHI-PROJECT-19K07077
[Book] Signal transduction systems involved in methylmercury-cytotoxicity. (In : Aschner M and Ceccatelli S (ed.))
- Author(s)
  Usuki F, Fujimura M
- Publisher
  Springer Science + Business Media, Berlin
- Data Source
  KAKENHI-PROJECT-20590135
[Journal Article] Cellular conditions responsible for methylmercury-mediated neurotoxicity.2022
- Author(s)
  Fujimura M, Usuki F
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 23 Issue: 13 Pages: 7218-7218
- DOI
  10.3390/ijms23137218
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07077
[Journal Article] Fasudil, a ROCK inhibitor, prevents neuropathic pain in Minamata disease model rats.2022
- Author(s)
  Fujimura M
- Journal Title
  
  Toxicol. Lett.
  
  Volume: 371 Pages: 38-45
- DOI
  10.1016/j.toxlet.2022.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07077
[Journal Article] Methylmercury induces hyperalgesia/allodynia through spinal cord dorsal horn neuronal activation and subsequent somatosensory cortical circuit formation in rats2021
- Author(s)
  Fujimura M, Usuki F, Nakamura A
- Journal Title
  
  Archives of Toxicology
  
  Volume: 95 Issue: 6 Pages: 2151-2162
- DOI
  10.1007/s00204-021-03047-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07077
[Journal Article] Fasudil, a Rho-Associated Coiled Coil-Forming Protein Kinase Inhibitor, Recovers Methylmercury-Induced Axonal Degeneration by Changing Microglial Phenotype in Rats2019
- Author(s)
  Fujimura M, Usuki F, Nakamura A
- Journal Title
  
  Toxicol Sci
  
  Volume: 168 Issue: 1 Pages: 126-136
- DOI
  10.1093/toxsci/kfy281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07077
[Journal Article] Local Vibration Stimuli Induce Mechanical Stress-Induced Factors and Facilitate Recovery From Immobilization-Induced Oxidative Myofiber Atrophy in Rats2019
- Author(s)
  Usuki F, Fujimura M, Nakamura A, Nakano J, Okita M, Higuchi I
- Journal Title
  
  Front Physiol
  
  Volume: 10 Pages: 759-759
- DOI
  10.3389/fphys.2019.00759
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07077
[Journal Article] Prenatal low-dose methylmercury exposure impairs neurite outgrowth and synaptic protein expression and suppresses TrkA pathway activity adn eEF1A1 expression in the rat cerebellum.2016
- Author(s)
  Fujimura M, Usuki F, Cheng J, Zhao W
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 298 Pages: 1-8
- DOI
  10.1016/j.taap.2016.03.002
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460187
[Journal Article] Decreased plasma thiol antioxidant barrier and selenoproteins as potential biomarkers for ongoing methylmercury intoxication and an individual protective capacity2016
- Author(s)
  Fusako Usuki, Masatake Fujimura
- Journal Title
  
  Archives of Toxicology
  
  Volume: unknown Issue: 4 Pages: 917-26
- DOI
  10.1007/s00204-015-1528-3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460402
[Journal Article] Assessing pre/post-weaning neurobehavioral development for perinatal exposure to low doses of methylmercury.2015
- Author(s)
  Cheng J, Fujimura M, Bo D.
- Journal Title
  
  Journal of Environmental Sciences (China)
  
  Volume: 38 Pages: 36-41
- DOI
  10.1016/j.jes.2015.05.027
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460187
[Journal Article] メチル水銀毒性とRho蛋白質.2015
- Author(s)
  藤村成剛
- Journal Title
  
  臨床環境医学
  
  Volume: 24 Pages: 79-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460187
[Journal Article] Effect of <i>in utero</i> exposure to endocrine disruptors on fetal steroidogenesis governed by the pituitary-gonad axis: a study in rats using different ways of administration2015
- Author(s)
  Kariyazono Y., Taura J., Hattori Y., Ishii Y., Narimatsu S., Fujimura M., Takeda T., Yamada H
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 40 Issue: 6 Pages: 909-916
- DOI
  10.2131/jts.40.909
- NAID
  130005108866
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15J03653, KAKENHI-PROJECT-24221004
[Journal Article] Low concentrations of methylmercury inhibit neural progenitor cell proliferation associated with up-regulation of glycogen synthase kinase 3β and subsequent degradation of cyclin E in rats.2015
- Author(s)
  Fujimura M, Usuki F.
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 288 Issue: 1 Pages: 19-25
- DOI
  10.1016/j.taap.2015.07.006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460187
[Journal Article] 水銀汚染と生物への影響. 特集: 水銀～その規制動向と処理技術2015
- Author(s)
  藤村成剛
- Journal Title
  
  環境浄化技術
  
  Volume: 14 Pages: 1-3
- Data Source
  KAKENHI-PROJECT-26460187
[Journal Article] Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: In vitro and in vivo effects of TrkA pathway activators.2015
- Author(s)
  Fujimura M, Usuki F
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 282 Issue: 3 Pages: 259-266
- DOI
  10.1016/j.taap.2014.12.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460187
[Journal Article] Low in situ expression of antioxidative enzymes in rat cerebellar granular cells susceptible to methylmercury2014
- Author(s)
  Fujimura M, Usuki F
- Journal Title
  
  Arch. Toxicol
  
  Volume: 89 Pages: 109-113
- Data Source
  KAKENHI-PROJECT-23590167
[Journal Article] Low in situ expression of antioxidative enzymes in rat cerebellar granular cells susceptible to methylmercury2014
- Author(s)
  Fujimura M, Usuki F
- Journal Title
  
  Arch. Toxicol.
  
  Volume: 88 Issue: 1 Pages: 109-113
- DOI
  10.1007/s00204-013-1089-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590167
[Journal Article] Neurobehavioral effects, c-Fos/Jun expression and tissue distribution in rat offspring prenatally co-exposed to MeHg and PFOA : PFOA impairs Hg retention2013
- Author(s)
  Cheng J, Fujimura M, Zhao W, Wang W
- Journal Title
  
  Chemosphere
  
  Volume: 91 Pages: 758-764
- Data Source
  KAKENHI-PROJECT-23590167
[Journal Article] Neurobehavioral effects, c-Fos/Jun expression and tissue distribution in rat offspring prenatally co-exposed to MeHg and PFOA: PFOA impairs Hg retention2013
- Author(s)
  Cheng J, Fujimura M, Zhao W, Wang W
- Journal Title
  
  Chemosphere
  
  Volume: 91 Pages: 758-764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590167
[Journal Article] Endoplasmic reticulum stress preconditioning attenuates methylmercury-induced cellular damage by inducing favorable stress responses.2013
- Author(s)
  Usuki F, Fujimura M, Yamashita A
- Journal Title
  
  Sci Rep
  
  Volume: 3 Issue: 1 Pages: 2346-2346
- DOI
  10.1038/srep02346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23687025, KAKENHI-PROJECT-25460402
[Journal Article] Perinatal exposure to low dose of methylmercury induces dysfunction of motor coordination with decreases of synaptophysin expression in the cerebellar granule cells of rats2012
- Author(s)
  Fujimura M, Cheng J, and Zhao W
- Journal Title
  
  Brain Res.
  
  Volume: 1464 Pages: 1-7
- DOI
  10.1016/j.brainres.2012.05.012
- NAID
  130005483670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24221004
[Journal Article] Differing effects of toxicants (methylmercury, inorganic mercury, lead, amyloid β and rotenone) on cultured rat cerebrocortical neurons: differential expression of Rho proteins associated with neurotoxicity2012
- Author(s)
  Fujimura M, and Usuki F
- Journal Title
  
  Toxicol. Sci.
  
  Volume: 126 Issue: 2 Pages: 506-514
- DOI
  10.1093/toxsci/kfr352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24221004
[Journal Article] Effects of methylmercury contained in a diet mimicking the Wayana Amerindians contamination through fish consumption: mercury accumulation, metallothionein induction, gene expression variations, and role of the chemokine CCL22012
- Author(s)
  Bourdineaud JP, Laclau M, Maury-Brachet R, Gonzalez P, Baudrimont M, Mesmer-Dudons N, Fujimura M, Marighetto A, Godefroy D, Rostene W, and Brethes D
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 13 Issue: 6 Pages: 7710-7738
- DOI
  10.3390/ijms13067710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24221004
[Journal Article] Dietary mercury exposure resulted in behavioral differences in mice contaminated with fish-associated methylmercury compared to methylmercury chloride added to diet2012
- Author(s)
  Bourdineaud JP, Marumoto M, Yasutake A, and Fujimura M
- Journal Title
  
  J. Biomed. Biotechnol.
  
  Volume: 2012 Pages: 681016-681016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24221004
[Journal Article] Perinatal exposure to low dose of methylmercury induces dysfunction of motor coordination with decreases of synaptophysin expression in the cerebellar granule cells of rats2012
- Author(s)
  Fujimura M, Cheng J, Zhao W
- Journal Title
  
  Brain Res
  
  Volume: 1464 Pages: 1-7
- NAID
  130005483670
- Data Source
  KAKENHI-PROJECT-23590167
[Journal Article] Effects of methylmercury contained in a diet mimicking the Wayana Amerindians contamination through fish consumption : mercury accumulation, metallothionein induction, gene expression variations, and role of the chemokine CCL22012
- Author(s)
  Bourdineaud JP, Laclau M, Maury-Brachet R, Gonzalez P, Baudrimont M, Mesmer-Dudons N, Fujimura M, Marighetto A, Godefroy D, Rostène W, Brèthes D
- Journal Title
  
  Int. J. Mol. Sci
  
  Volume: 13 Pages: 7710-7738
- Data Source
  KAKENHI-PROJECT-23590167
[Journal Article] Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.2011
- Author(s)
  Fujimura M, Usuki F, Kawamura M, Izumo S
- Journal Title
  
  Toxicol. Appl.Pharmacol. 250
  
  Pages: 1-9
- Data Source
  KAKENHI-PROJECT-20590135
[Journal Article] Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.2011
- Author(s)
  Fujimura M, Usuki F, Kawamura M, Izumo S.
- Journal Title
  
  Toxicol.Appl.Pharmacol.
  
  Volume: 250 Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590135
[Journal Article] Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons2009
- Author(s)
  Masatake Fujimura, Fusako Usuki, Masumi Sawada, William Rostene, David Godefroy, Akihiko Takashima
- Journal Title
  
  Neurotoxicology 30
  
  Pages: 16-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590135
[Journal Article] Methylmercury exposure downregulates the expression of Racl, leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons.2009
- Author(s)
  Fujimura M, Usuki F, Sawada M, Rostene W, Godefroy D, Takashima A
- Journal Title
  
  Neurotoxicology 30
  
  Pages: 16-22
- Data Source
  KAKENHI-PROJECT-20590135
[Presentation] メチル水銀曝露ラットに生じる疼痛閾値低下に対する各種薬剤の効果2023
- Author(s)
  藤村成剛, 臼杵扶佐子, 中村篤
- Organizer
  令和5年度メチル水銀研究ミーティング
- Data Source
  KAKENHI-PROJECT-19K07077
[Presentation] メチル水銀毒性に対する耐性/脆弱性診断のための血中バイオマーカーの探索研究2023
- Author(s)
  藤村成剛, 鵜木隆光
- Organizer
  メタルバイオサイエンス研究会2023
- Data Source
  KAKENHI-PROJECT-23K25022
[Presentation] メチル水銀曝露はラット足底部に末梢および中枢神経傷害を介した神経障害性疼痛を引き起こす2023
- Author(s)
  藤村成剛
- Organizer
  第50回日本毒性学会
- Data Source
  KAKENHI-PROJECT-19K07077
[Presentation] Methylmercury induces allodynia through activation of inflammatory microglia in spinal cord and subsequent stimulation in somatosensory cortex od rats2021
- Author(s)
  Fujimura M, Usuki F, Nakamura A
- Organizer
  60th Annual Meeting, Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07077
[Presentation] メチル水銀曝露はラット足底部に神経障害性疼痛の1種である疼痛閾値低下 (アロディニア) を引き起こす2020
- Author(s)
  藤村成剛, 臼杵扶佐子, 中村篤
- Organizer
  メタルバイオサイエンス研究会2020
- Data Source
  KAKENHI-PROJECT-19K07077
[Presentation] 局所振動刺激はラットにおいてメカノストレス因子を誘導し不動化による筋萎縮からの回復を促進する2019
- Author(s)
  藤村成剛, 臼杵扶佐子, 中村篤, 中野治郎, 沖田実, 樋口逸郎
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07077
[Presentation] Fasudil, a ROCK inhibitor, recovers methylmercury-induced axonal degeneration by changing microglial phenotype in rats2019
- Author(s)
  Fujimura M, Usuki F, Nakamura A
- Organizer
  14th International Conference on Mercury as a Global Pollutant
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07077
[Presentation] Mild endoplasmic reticulum stress preconditioning upregulates gene expression of membrane transporters.2016
- Author(s)
  Fusako Usuki, Masatake Fujimura
- Organizer
  55th Annual Meeting of Society of Toxicology
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-03-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460402
[Presentation] メチル水銀の妊娠期飲水曝露が胎児のメタボロームに及ぼす影響と性差2016
- Author(s)
  武田知起, 人見将也, 服部友紀子, 藤村成剛, 石井祐次, 山田英之
- Organizer
  平成27年度メチル水銀研究ミーティング
- Place of Presentation
  LMJ東京研修センター(東京都文京区)
- Year and Date
  2016-01-07
- Data Source
  KAKENHI-PROJECT-24221004
[Presentation] メチル水銀中毒バイオマーカーとしての血漿チオール抗酸化バリアとセレノ蛋白質.2016
- Author(s)
  臼杵扶佐子、藤村成剛
- Organizer
  メチル水銀ミーテイング
- Place of Presentation
  東京
- Year and Date
  2016-01-07
- Invited
- Data Source
  KAKENHI-PROJECT-25460402
[Presentation] Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.2015
- Author(s)
  Fujimura M, Usuki F.
- Organizer
  ASIATOX 2015
- Place of Presentation
  韓国・済州
- Year and Date
  2015-06-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460187
[Presentation] メチル水銀毒性とRho蛋白質.2015
- Author(s)
  藤村成剛
- Organizer
  第24回日本臨床環境医学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-06-06
- Invited
- Data Source
  KAKENHI-PROJECT-26460187
[Presentation] Methylmercury-induced stress responses in astroglia cells2015
- Author(s)
  Fusako Usuki, Masatake Fujimura
- Organizer
  Society of Toxicology 54th Annual Meeting
- Place of Presentation
  SanDiego, USA
- Year and Date
  2015-03-24
- Data Source
  KAKENHI-PROJECT-25460402
[Presentation] 低用量メチル水銀のラット胎児期曝露はTrkA-eEF1A1経路の抑制を介して神経突起形成不全およびシナプス恒常性変化を引き起こす.2015
- Author(s)
  藤村成剛, 臼杵扶佐子.
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26460187
[Presentation] メチル水銀の胎児期曝露による小脳神経シナプス形成におよぼす影響.2015
- Author(s)
  藤村成剛, Cheng J, Zhao W.
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-26460187
[Presentation] メチル水銀の妊娠期飲水曝露による胎児の肝メタボローム変動とその性差 : 毒性に直結する因子抽出の試み2015
- Author(s)
  人見将也, 武田知起, 服部友紀子, 藤村成剛, 石井祐次, 山田英之
- Organizer
  フォーラム2015 : 衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸学院大学ポートアイランドキャンバス(兵庫県神戸市)
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-24221004
[Presentation] メチル水銀の妊娠期曝露による胎児脳下垂体および副腎のホルモン合成系への影響と性差2014
- Author(s)
  武田知起, 服部友紀子, 仮屋薗侑大, 藤村成剛, 石井祐次, 山田英之
- Organizer
  平成26年度メチル水銀研究ミーティング
- Place of Presentation
  東京
- Year and Date
  2014-12-05
- Data Source
  KAKENHI-PROJECT-24221004
[Presentation] メチル水銀の妊娠期飲水曝露が胎児の脳下垂体、生殖腺および副腎のホルモン発現に及ぼす影響2014
- Author(s)
  武田知起, 服部友紀子, 仮屋薗侑大, 藤村成剛, 石井祐次山田英之
- Organizer
  フォーラム2014: 衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば
- Year and Date
  2014-09-19
- Data Source
  KAKENHI-PROJECT-24221004
[Presentation] Effects of methylmercury on heart rate variability in the rat2013
- Author(s)
  Sasaki M, Yamamoto M, and Fujimura M
- Organizer
  52nd Annual Meeting of the Society of Toxicology
- Place of Presentation
  San Antonio, TX, USA
- Data Source
  KAKENHI-PROJECT-24221004
[Presentation] ラットメチル水銀亜急性中毒モデルにおける血管内皮細胞成長因子(VEGF) 抑制療法の検討2013
- Author(s)
  高橋哲哉, 藤村成剛, 臼杵扶佐子, 西澤正豊, 下畑享良
- Organizer
  第25回日本脳循環代謝学会総会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-24659426
[Presentation] メチル水銀による翻訳伸長因子eEF1Aの発現低下2013
- Author(s)
  藤村成剛
- Organizer
  平成25年度メチル水銀研究ミーティング
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23590167
[Presentation] ラットメチル水銀亜急性中毒モデルにおける血管内皮細胞成長因子(VEGF) 抑制療法の検討2013
- Author(s)
  高橋哲哉, 藤村成剛, 臼杵扶佐子, 西澤正豊, 下畑享良
- Organizer
  第54 回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659426
[Presentation] Mild endoplasmic reticulum stress preconditioning attenuates methylmercury-induced cellular damage by inducing favorable stress responses2013
- Author(s)
  Usuki F, Fujimura M, and Yamashita A
- Organizer
  52nd Annual Meeting of the Society of Toxicology
- Place of Presentation
  San Antonio, TX, USA
- Data Source
  KAKENHI-PROJECT-24221004
[Presentation] Perinatal exposure to low dose of methylmercury induces dysfunction of motor coordination with decreases of synaptophysin expression in the cerebellar granule cells of rats2013
- Author(s)
  Fujimura M, Cheng J, Zhao W
- Organizer
  52^<nd> Society of Toxicology
- Data Source
  KAKENHI-PROJECT-23590167
[Presentation] Vascular endothelial growth factor upregulation in blood brain barrier in rat models of subacute methylmercury intoxication2013
- Author(s)
  Takahashi T, Fujimura M, Usuki F, Nishizawa M, and Shimohata Y
- Organizer
  65th American Academy of Neurology
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-24221004
[Presentation] Perinatal exposure to low dose of methylmercury induces dysfunction of motor coordination with decreases of synaptophysin expression in the cerebellar granule cells of rats2013
- Author(s)
  Fujimura M, Cheng J, and Zhao W
- Organizer
  52nd Annual Meeting of the Society of Toxicology
- Place of Presentation
  San Antonio, TX, USA
- Data Source
  KAKENHI-PROJECT-24221004
[Presentation] Low in situ expression of antioxidative enzymes in rat cerebellar granular cells susceptible to methylmercury2013
- Author(s)
  Fujimura M, Usuki F
- Organizer
  第36回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23590167
[Presentation] 内分泌撹乱物質の胎児•性ホルモン合成系への影響とその機構解析2013
- Author(s)
  仮屋薗侑大, 武田知起, 田浦順樹, 石井祐次, 藤村成剛, 山田英之
- Organizer
  フォーラム2013：衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-24221004
[Presentation] ラットメチル水銀亜急性中毒モデルにおける血管内皮細胞成長因子(VEGF) 発現の検討2012
- Author(s)
  高橋哲哉, 藤村成剛, 臼杵扶佐子, 西澤正豊, 下畑享良
- Organizer
  第24回日本脳循環代謝学会総会
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-24221004
[Presentation] メチル水銀の選択的細胞傷害 -マイクロダイセクション法を用いた各種神経細胞における抗酸化酵素の発現解析-2012
- Author(s)
  藤村成剛
- Organizer
  平成24年度メチル水銀・カドミウム研究ミーティング
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23590167
[Presentation] Differing effects of toxicants on cultured rat cerebrocortical neurons: Differential expression of Rho proteins associated with neurotoxicity2012
- Author(s)
  Fujimura M, and Usuki F
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-24221004
[Presentation] Neuritic degeneration contributes to methylmercury induced neuronal cell death.2011
- Author(s)
  Fujimura M
- Organizer
  NIMD forum 2011
- Data Source
  KAKENHI-PROJECT-20590135
[Presentation] Neuritic degeneration contributes to methylmercury induced neuronal cell death.2011
- Author(s)
  Fujimura M.
- Organizer
  NIMD forum 2011
- Place of Presentation
  Minamata, Japan
- Year and Date
  2011-01-28
- Data Source
  KAKENHI-PROJECT-20590135
[Presentation] Methylmercury exposure downregulates the expression of Racl, leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons.2010
- Author(s)
  Fujimura M, Usuki F, Rostene W, Godefroy D, Takashima A
- Organizer
  48^<th> Society of Toxicology's annual meeting
- Place of Presentation
  Salt Lake City, USA
- Year and Date
  2010-03-10
- Data Source
  KAKENHI-PROJECT-20590135
[Presentation] Molecular mechanism of methylmercury-induced neurotoxicity in cerebrocortical neuron.2008
- Author(s)
  Fujimura M
- Organizer
  Forum 2008 : Pharmaceutical Health and Environmental Toxicology
- Data Source
  KAKENHI-PROJECT-20590135
[Presentation] メチル水銀による大脳皮質神経細胞の細胞死機構2008
- Author(s)
  藤村成剛
- Organizer
  フォーラム2008:衛生薬学・トキシコロジー“健康をまもり、健康をはぐくむ
- Place of Presentation
  熊本市市民会館熊本市国際交流会館
- Year and Date
  2008-10-17
- Data Source
  KAKENHI-PROJECT-20590135
[Presentation] Vascular endothelial growth factor upregulation in blood brain barrier in rat models of subacute methylmercury intoxication
- Author(s)
  Tetsuya Takahashi, Masatake Fujimura, Fusako Usuki, Masatoyo Nishizawa, Takayoshi Shimohata
- Organizer
  65th American Academy of Neurology Annual Meeting
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-24659426
[Presentation] ラットメチル水銀亜急性中毒モデルにおける血管内皮細胞成長因子（VEGF）発現の検討
- Author(s)
  高橋　哲哉、藤村成剛、臼杵扶佐子、西澤正豊、下畑享良
- Organizer
  第53回神経学会学術集会
- Place of Presentation
  東京・国際フォーラム
- Data Source
  KAKENHI-PROJECT-24659426
[Presentation] Activation of TrkA pathway by GM1 ganglioside and its analog prevents methylmercury-induced nerve damage in vitro and in vivo.
- Author(s)
  Fujimura M, Usuki F
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26460187
[Presentation] Low level of methylmercury inhibits cell proliferation through the activation of glycogen synthase kinase 3and subsequent degradation of cyclin E in cortical progenitor cells of rats.
- Author(s)
  Fujimura M, Usuki F
- Organizer
  54th Society of Toxicology
- Place of Presentation
  米国・サンディエゴ
- Year and Date
  2015-03-22 – 2015-03-26
- Data Source
  KAKENHI-PROJECT-26460187

1. USUKI Fusako (50185013)

# of Collaborated Projects: 7 results

# of Collaborated Products: 34 results
2. IZUMO Shuji (30143811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. SHIMOHATA Takayoshi (60361911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. TAKAHASHI Tetsuya (20515663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. YAMASHITA Akio (20405020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 山田英之 (40142351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 成松鎮雄 (20113037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山本緑 (00336075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 姫野勝 (50037602)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中村篤 (40785713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
11. 鵜木隆光 (00742868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 中村政明 (50399672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Fujimura Masatake 藤村 成剛

FUJIMURA Masatake 藤村 成剛

Research Projects

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Co-Researchers

Development of a biomarker that can objectively determine differences in individual susceptibility to methylmercury poisoningPrincipal Investigator

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Experimental research on regenerative treatment of axon and muscle fiber for nerve and muscle dysfunction by methylmercuryPrincipal Investigator

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Research on inciting factor of neurological symptoms following low dose methylmercury exposure in fetal periodPrincipal Investigator

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Research on environmental stresses-induced change in nonsense-mediated mRNA decay (NMD) activity and its effect on pathological conditions

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環境汚染物質による性未成熟のインプリンティングと育児破綻の分子機構

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Analysis of vascular endothelial growth factor as novel therapeutic target for methylmercury poisoning

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Experimental research on selective neuronal damage by methylmercury using microdissection methodPrincipal Investigator

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Experimental study on effect of Rho kinase inhibitors against neurological impairment by environmental toxinsPrincipal Investigator

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[Book] Handbook of Neurotoxicity2021

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[Book] Signal transduction systems involved in methylmercury-cytotoxicity. (In : Aschner M and Ceccatelli S (ed.))

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[Journal Article] Cellular conditions responsible for methylmercury-mediated neurotoxicity.2022

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[Journal Article] Fasudil, a ROCK inhibitor, prevents neuropathic pain in Minamata disease model rats.2022

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[Journal Article] Methylmercury induces hyperalgesia/allodynia through spinal cord dorsal horn neuronal activation and subsequent somatosensory cortical circuit formation in rats2021

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[Journal Article] Fasudil, a Rho-Associated Coiled Coil-Forming Protein Kinase Inhibitor, Recovers Methylmercury-Induced Axonal Degeneration by Changing Microglial Phenotype in Rats2019

Author(s)

Fujimura Masatake 藤村成剛

FUJIMURA Masatake 藤村成剛