Motegi Sei-ichiro 茂木精一郎

… Alternative Names

MOTEGI Sei-ichiro 茂木精一郎

茂木精一郎モテギセイイチロウ

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Researcher Number	20420185
Other IDs
Affiliation (Current)	2025: 群馬大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 群馬大学, 大学院医学系研究科, 教授 2017 – 2019: 群馬大学, 大学院医学系研究科, 准教授 2016: 群馬大学, 大学院医学系研究科, 講師 2012 – 2015: 群馬大学, 医学(系)研究科(研究院), 講師 2013: 群馬大学, 大学院医学系研究科, 講師 2008: 群馬大, 生体調節研究所, 研究員 2007: Gunma University, 生体調節研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related / Dermatology Except Principal Investigator Dermatology / Basic Section 53050:Dermatology-related / Basic Section 52010:General internal medicine-related / Collagenous pathology/Allergology / Medical pharmacy
Keywords	Principal Investigator 間葉系幹細胞 / 褥瘡 / 創傷治癒 / 悪性黒色腫 / フェロトーシス / アトピー性皮膚炎 / 温度感受性チャネル / 温度感受性TRPチャネル / TRPV4 / 尋常性乾癬 … More / 酸化ストレス / エクソソーム / 酸化ストレス障害 / 急性期褥瘡 / 線維化 / 強皮症 / 血管新生 / サイトカイン / 細胞間相互作用 / 接触皮膚炎 / T細胞 / ランゲルハンス細胞 / 樹状細胞 / CD47 / SHPS-1 … More Except Principal Investigator 線維化 / 強皮症 / 全身性強皮症 / 皮膚硬化 / 膠原病 / 治療 / 間葉系幹細胞 / MFG-E8 / エクソソーム / 皮膚線維化 / ラミンＡ / Werner症候群 / ウエルナー症候群 / ラミンA / 早老症 / 老化 / NK細胞 / アトピー性皮膚炎 / ATP / 細胞外ATP / MM07 / APJアゴニスト / アペリン / 細胞内シグナル / 腎性全身線維症 / 石灰化 / ガドリニウム / 腎性全身性線維症 Less

急性期褥瘡におけるフェロトーシス制御機構と新規治療への応用Principal Investigator
- Principal Investigator
  
  茂木精一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Gunma University
Role of temperature-sensitive TRP channels in skin inflammatory diseases and their therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  Motegi Sei-ichiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Gunma University
Treatment for skin sclerosis in systemic sclerosis by MSCs-derived exosome
- Principal Investigator
  
  YOKOYAMA Yoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Gunma University
Elucidation of the pathogenesis of skin sclerosis and lipoatrophy in progeria and development of novel treatment
- Principal Investigator
  
  Endo Yukie
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Gunma University
Elucidation of the pathogenesis of acute-phase pressure ulcers and development of novel therapies: Focusing on mesenchymal stem cell-derived exosomesPrincipal Investigator
- Principal Investigator
  
  Motegi Sei-ichiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Gunma University
Development of new treatment in systemic sclerosis by regulating of apelin/APJ signaling
- Principal Investigator
  
  Yokoyama Yoko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Gunma University
The role of extracellular ATP in the pathogenesis of skin sclerosis and vasculopathy in systemic sclerosis
- Principal Investigator
  
  Ishikawa Osamu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
Development of a new treatment for atopic dermatitis by activating NK cells
- Principal Investigator
  
  Kishi Chikako
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
Elucidation of the regulation by secreted protein MFG-E8, and the development of new therapyPrincipal Investigator
- Principal Investigator
  
  Motegi Sei-ichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
The regulation of fibrosis and calcification by gadolinium
- Principal Investigator
  
  YAMADA Kazuya
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
Role of mesenchymal stem cells in tumor angiogenesisPrincipal Investigator
- Principal Investigator
  
  MOTEGI Sei-ichiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University
新しい細胞間シグナル系による皮膚免疫機能の制御Principal Investigator
- Principal Investigator
  
  茂木精一郎
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Gunma University

All 2023 2022 2021 2019 2018 2017 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] TRPV4 Regulates the Development of Psoriasis by Controlling Adenosine Triphosphate Expression in Keratinocytes and the Neuroimmune System2023
- Author(s)
  Amalia Syahla Nisaa、Baral Hritu、Fujiwara Chisako、Uchiyama Akihiko、Inoue Yuta、Yamazaki Sahori、Ishikawa Mai、Kosaka Keiji、Sekiguchi Akiko、Yokoyama Yoko、Ogino Sachiko、Torii Ryoko、Hosoi Mari、Shibasaki Koji、Motegi Sei-ichiro
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 143 Issue: 12 Pages: 2356-2365
- DOI
  10.1016/j.jid.2023.05.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06434, KAKENHI-PROJECT-21K08340
[Journal Article] Antifibrotic effects and mechanisms of mesenchymal stem cell-derived exosomes in a systemic sclerosis mouse model: Possible contribution of miR-196b-5p2021
- Author(s)
  Baral Hritu、Uchiyama Akihiko、Yokoyama Yoko、Sekiguchi Akiko、Yamazaki Sahori、Amalia Syahla Nisaa、Inoue Yuta、Ogino Sachiko、Torii Ryoko、Hosoi Mari、Matsuzaki Toshiyuki、Motegi Sei-ichiro
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 104 Issue: 1 Pages: 39-47
- DOI
  10.1016/j.jdermsci.2021.08.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08685
[Journal Article] The Regulation of Skin Fibrosis in Systemic Sclerosis by Extracellular ATP via P2Y2 Purinergic Receptor.2019
- Author(s)
  Perera LMB, Sekiguchi A, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Yokoyama Y, Ogino S, Torii R, Hosoi M, Ishikawa O, Motegi S
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 139 Pages: 890-899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10205
[Journal Article] Inhibitory Regulation of Skin Fibrosis in Systemic Sclerosis by Apelin/APJ Signaling.2018
- Author(s)
  Yokoyama Y, Sekiguchi A, Fujiwara C, Uchiyama A, Uehara A, Ogino S, Torii R, Ishikawa O, Motegi S
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: 70 Issue: 10 Pages: 1661-72
- DOI
  10.1002/art.40533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09968
[Journal Article] MFG-E8 drives melanoma growth by stimulating mesenchymal stromal cell-induced angiogenesis and M2 polarization of tumor-associated macrophages2016
- Author(s)
  Yamada K, Uchiyama A, Uehara A, Perera B, Ogino S, Yokoyama Y, Takeuchi Y, Udey MC, Ishikawa O, and Motegi S
- Journal Title
  
  Cancer Research
  
  Volume: 76 Issue: 14 Pages: 4283-92
- DOI
  10.1158/0008-5472.can-15-2812
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461654
[Journal Article] Protective Effect of MFG-E8 after Cutaneous Ischemia-Reperfusion Injury.2015
- Author(s)
  Akihiko Uchiyama, Kazuya Yamada, Buddhini Perera, Sachiko Ogino, Yoko Yokoyama, Yuko Takeuchi, Osamu Ishikawa, and Sei-ichiro Motegi
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 135 Issue: 4 Pages: 1157-65
- DOI
  10.1038/jid.2014.515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461654
[Presentation] TRPV4 regulates psoriasis-like dermatitis via enhancement of Th17 pathway by ATP and neuropeptides production in mouse model2022
- Author(s)
  Syahla N. Amalia, Akihiko Uchiyama, Hritu Baral, Chisako Fujiwara, Yuta Inoue, Yoko Yokoyama, Sachiko Ogino, Ryoko Torii, Mari Hosoi, Sei-ichiro Motegi
- Organizer
  The 47th Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08340
[Presentation] Antifibrotic effects and mechanisms of miR-196b-5p of mesenchymal stem cell-derived exosomes in a systemic sclerosis mouse model2021
- Author(s)
  Hritu Baral, Akihiko Uchiyama, Yoko Yokoyama, Akiko Sekiguchi, Sahori Yamazaki, Syahla Nisaa Amalia, Yuta Inoue, Sachiko Ogino, Ryoko Torii, Mari Hosoi, Toshiyuki Matsuzaki, Sei-ichiro Motegi
- Organizer
  The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08685
[Presentation] Inhibitory regulation of skin fibrosis in systemic sclerosis by apelin/APJ signaling2017
- Author(s)
  Yoko Yokoyama, Akiko Sekiguchi, Chisako Fujiwara, Akihiko Uchiyama, Sahori Yamazaki, Sachiko Ogino, Ryoko Torii, Osamu Ishikawa, and Sei-ichiro Motegi
- Organizer
  The 42nd annual meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09968
[Presentation] The regulation of skin fibrosis in systemic sclerosis by extracellular ATP via P2Y2 purinergic receptor2017
- Author(s)
  Buddhini Perera, Akiko Sekiguchi, Akihiko Uchiyama, Akihito Uehara, Chisako Fujwara, Sahori Yamazaki, Osamu Ishikawa, Sei-ichiro Motegi
- Organizer
  The 42nd annual meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10205
[Presentation] Mechanistic insight into the extracellular ATP-induced IL-6 via purinergic receptor in systemic sclerosis dermal fibroblasts2017
- Author(s)
  Buddhini Perera, Akihiko Uchiyama, Akiko Sekiguchi, Chisako Fujwara, Osamu Ishikawa, Sei-ichiro Motegi
- Organizer
  2017 Society for Investigative Dermatology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10205
[Presentation] Inhibitory regulation of MFGE-8 on fibrosis in systemic sclerosis.2016
- Author(s)
  Fujiwara C, Uehara A, Yokoyama Y, Ogino S, Uchiyama A, sekiguchi A, Ogino S, Ishikawa O, Motegi S.
- Organizer
  The 41th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  Sendai
- Year and Date
  2016-12-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461654
[Presentation] MFG-E8 promotes mesenchymal stem cells-induced angiogenesis2015
- Author(s)
  Kazuya Yamada, Akihiko Uchiyama, Sachiko Ogino, Buddhini Perera, Yoko Yokoyama, Yuko Takeuchi, Osamu Ishikawa, and Sei-ichiro Motegi
- Organizer
  The 45th Annual ESDR Meeting
- Place of Presentation
  Rotterdam
- Year and Date
  2015-09-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461654
[Presentation] 腫瘍血管新生における間葉系幹細胞の役割2013
- Author(s)
  茂木精一郎
- Organizer
  日本皮膚科学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24791135
[Presentation] 間葉系幹細胞による悪性黒色腫の腫瘍血管新生の制御2013
- Author(s)
  山田和哉, 内山明彦, 上原顕仁, 荻野幸子, 横山洋子, 竹内裕子, 石川治, 茂木精一郎
- Organizer
  第60回北関東医学会総会
- Place of Presentation
  前橋
- Year and Date
  2013-09-26
- Data Source
  KAKENHI-PROJECT-24791135
[Presentation] 間葉系幹細胞による悪性黒色腫の腫瘍血管新生の制御2013
- Author(s)
  山田和哉, 内山明彦, 上原顕仁, 荻野幸子, 横山洋子, 竹内裕子, Mark C. Udey, 石川治, 茂木精一郎
- Organizer
  第20回新群筑皮膚合同研究会
- Place of Presentation
  前橋
- Year and Date
  2013-10-18
- Data Source
  KAKENHI-PROJECT-24791135
[Presentation] 腫瘍血管新生における間葉系幹細胞の役割2013
- Author(s)
  茂木　精一郎、山田　和哉、内山　明彦、上原　顕仁、石川　治
- Organizer
  第112回日本皮膚科学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24791135
[Presentation] Role of endothelin-1/endothelin receptor signaling in fibrosis and calcification in nephrogenic systemic fibrosis2013
- Author(s)
  Motegi S, Okada E, Uchiyama A, Yamada K, Uehara A, Ogino S, Takeuchi Y, Ishikawa O
- Organizer
  International Investiagtive Dermatology
- Place of Presentation
  Edinburgh
- Data Source
  KAKENHI-PROJECT-24790146
[Presentation] Protective effect of MFG-E8 after cutaneous ischemia-reperfusion injury
- Author(s)
  Akihiko Uchiyama, Kazuya Yamada, Buddhini Perera, Sachiko Ogino, Yoko Yokoyama, Yuko Takeuchi, Osamu Ishikawa, and Sei-ichiro Motegi
- Organizer
  39th Japanese Society for Investigative Dermatology
- Place of Presentation
  ホテル阪急エキスポパーク（大阪府吹田市）
- Year and Date
  2014-12-12 – 2014-12-14
- Data Source
  KAKENHI-PROJECT-26461654
[Presentation] MFG-E8 promotes mesenchymal stem cells-induced angiogenesis in malignant melanoma
- Author(s)
  Kazuya Yamada, Akihiko Uchiyama, Buddhini Perera, Sachiko Ogino, Yoko Yokoyama, Yuko Takeuchi, Osamu Ishikawa, and Sei-ichiro Motegi
- Organizer
  39th Japanese Society for Investigative Dermatology
- Place of Presentation
  ホテル阪急エキスポパーク（大阪府吹田市）
- Year and Date
  2014-12-12 – 2014-12-14
- Data Source
  KAKENHI-PROJECT-26461654

1. Yokoyama Yoko (00241901)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. YAMADA Kazuya (90420190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. Ishikawa Osamu (90168188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. Kishi Chikako (60402707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Endo Yukie (00372350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 天野博雄 (70302487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 柴崎貢志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Motegi Sei-ichiro 茂木 精一郎

MOTEGI Sei-ichiro 茂木 精一郎

茂木 精一郎 モテギ セイイチロウ

Research Projects

Research Products

Co-Researchers

急性期褥瘡におけるフェロトーシス制御機構と新規治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of temperature-sensitive TRP channels in skin inflammatory diseases and their therapeutic applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Treatment for skin sclerosis in systemic sclerosis by MSCs-derived exosome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathogenesis of skin sclerosis and lipoatrophy in progeria and development of novel treatment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathogenesis of acute-phase pressure ulcers and development of novel therapies: Focusing on mesenchymal stem cell-derived exosomesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new treatment in systemic sclerosis by regulating of apelin/APJ signaling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of extracellular ATP in the pathogenesis of skin sclerosis and vasculopathy in systemic sclerosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new treatment for atopic dermatitis by activating NK cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the regulation by secreted protein MFG-E8, and the development of new therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The regulation of fibrosis and calcification by gadolinium

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of mesenchymal stem cells in tumor angiogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新しい細胞間シグナル系による皮膚免疫機能の制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] TRPV4 Regulates the Development of Psoriasis by Controlling Adenosine Triphosphate Expression in Keratinocytes and the Neuroimmune System2023

Author(s)

Motegi Sei-ichiro 茂木精一郎

MOTEGI Sei-ichiro 茂木精一郎

茂木精一郎モテギセイイチロウ