NISHIMURA Go 西村剛

Researcher Number	20422305
Affiliation (based on the past Project Information) *help	2011: 東京大学, 医学部・附属病院, 助教 2007 – 2011: 東京大学, 医学部附属病院, 助教 2010: 東京大学, 医学部附属病院, 特任助教 2008: The University of Tokyo, 医学部・附属病院, 助教 2007: The University of Tokyo, Hospital, Intern Doctor 2007: The University of Tokyo, 医学部附属病院, 医員 2006: 東京大学, 医学部附属病院, 非常勤医員
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine
Keywords	Principal Investigator 大動脈弁 / TGFβ / 転写因子SIP1 / BMP / TGF / 分子血管病態学 / 遺伝子発現 / TFGβ / 肺動脈弁 / 転写因子δEF1 … More Except Principal Investigator … More 動脈硬化 / KLF5 / メタボリックシンドローム / 分子イメージング / Transcriptional regulation / Metabolic syndrome / Atherosclerosis / Translational research / Diabetes mellitus / Cardiovascular disease / 転写調節 / トランスレーショナルリサーチ / 糖尿病 / 循環器・高血圧 / 診断 / ナノ粒子 / 虚血性心疾患 / 不安定プラーク / 翻訳後修飾 / 小胞体ストレス / 転写因子 / 慢性炎症 / 血管新生 / 癌 / 遺伝子治療 / siRNA / ナノDDS Less

Analysis of the transcriptional control mechanism which regulates generation, development and disease of cardiovascular systemPrincipal Investigator
- Principal Investigator
  
  NISHIMURA Go
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
ER stress and posttranslational modification pathways in cardiometabolic syndrome
- Principal Investigator
  
  MANABBE Ichiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
高機能ナノ粒子を用いた不安定プラークの診断=治療法の開発
- Principal Investigator
  
  眞鍋一郎
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Analysis of the transcriptional control mechanism which regulates cell differentiation and phenotype alteration in vascular diseasePrincipal Investigator
- Principal Investigator
  
  NISHIMURA Go
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
高機能ナノ粒子によるsiRNA治療法・分子イメージング法の開発
- Principal Investigator
  
  MANABBE Ichiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Transcription factor networks in blood vessel-metabolic system crosstalk and metabolic syndrome
- Principal Investigator
  
  MANABE Ichiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo

All 2010 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.2010
- Author(s)
  Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K.
- Journal Title
  
  J Clin Invest 120
  
  Pages: 179-190
- NAID
  120003783344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390220
[Journal Article] Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload.2010
- Author(s)
  Takeda N, Manabe I, Uchino Y, Eguchi K, Matsumoto S, Nishimura S, Shindo T, Sano M, Otsu K, Snider P, Conway SJ, Nagai R.
- Journal Title
  
  J Clin Invest 120
  
  Pages: 254-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390220
[Journal Article] FGF-2-induced HGF secretion by adipose-derived stromal cells inhibits post-injury fibrogenesis through a JNK-dependent mechanism.2009
- Author(s)
  Suga H, Eto H, Shigeura T, Inoue K, Aoi N, Kato H, Nishimura S, Manabe I, Gonda K, Yoshimura K.
- Journal Title
  
  Stem Cells 27
  
  Pages: 238-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390220
[Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.2009
- Author(s)
  Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R.
- Journal Title
  
  Nat Med 8
  
  Pages: 914-920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390220
[Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.2009
- Author(s)
  Nishimura S
- Journal Title
  
  Nature Medicine 15
  
  Pages: 914-920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390220
[Journal Article] A nanoparticle system specifically designed to deliver siRNA inhibits tumor growth in vivo.2009
- Author(s)
  Yagi N, Manabe I, Tottori T, Ishihara A, Ogata F, Kim JH, Nishimura S, Fujiu K, Oishi Y, Itaka K, Kato Y, Yamauchi M, Nagai R.
- Journal Title
  
  Cancer Res 69
  
  Pages: 6531-6538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390220
[Journal Article] In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue2008
- Author(s)
  Nishimura S, Manabe I, Nagasaki M, Seo K, Yamashita H, Hosoya Y, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S.
- Journal Title
  
  J Clin Invest 118(2)
  
  Pages: 710-721
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390230
[Journal Article] In vivo imaging revealed local cell dynamics in obese adipose tissue inflammation2008
- Author(s)
  Nishimura S
- Journal Title
  
  J Clin Invest 118
  
  Pages: 710-721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390230
[Journal Article] In vivo imaging in mice reveals local cell dynamics and inflammation inobese adipose tissue.2008
- Author(s)
  Nishimura S
- Journal Title
  
  J. Clin Invest 118
  
  Pages: 710-721
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390230
[Journal Article] Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels2007
- Author(s)
  Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Yamashita H, Fujita H, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S.
- Journal Title
  
  Diabetes 56(6)
  
  Pages: 1517-1526
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390230
[Journal Article] Adipogenesisin Obesity Requires Close Interplay Between Differentiating Adipocytes, Stromal Cells, and Blood Vessels2007
- Author(s)
  Nishimura S
- Journal Title
  
  Diabetes 56
  
  Pages: 1517-1526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390230
[Journal Article] DeltaEFI mediates TGF-beta signaling in vascular smooth muscle cell differentiation.2006
- Author(s)
  Nishimura G
- Journal Title
  
  Dev Cell 11・1
  
  Pages: 93-104
- Data Source
  KAKENHI-PROJECT-18390230
[Journal Article] deltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation.2006
- Author(s)
  Nishimura G
- Journal Title
  
  Dev Cell 11
  
  Pages: 93-104
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390230
[Journal Article] deltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation2006
- Author(s)
  Nishimura G, Manabe I, Tsushima K, Fujiu K, Oishi Y, Imai Y, Maemura K, Miyagishi M, Higashi Y, Kondoh H, Nagai R.
- Journal Title
  
  Dev Cell 11(1)
  
  Pages: 93-104
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390230
[Presentation] Smad Interacting Protein 1 (SIP1) controls arterial valve development2009
- Author(s)
  西村剛
- Organizer
  第73回日本循環器学会学術集会
- Place of Presentation
  大阪ホテルNCB
- Year and Date
  2009-03-22
- Data Source
  KAKENHI-PROJECT-19790519
[Presentation] Smad Interacting Protein 1 controls arterial valve development2009
- Author(s)
  西村剛
- Organizer
  第73回日本循環器学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2009-03-22
- Data Source
  KAKENHI-PROJECT-19790519
[Presentation] In Vivo Molecular Imaging Revealed Chronic Inflammation and Increased Adhesion Molecules in Obese Adipose Tissue in Mice2008
- Author(s)
  Nishimura S
- Organizer
  American Heart Association Scientific Sessions 2008
- Place of Presentation
  ニューオリンズ、米国
- Year and Date
  2008-11-11
- Data Source
  KAKENHI-PROJECT-20659124
[Presentation] KLF5 Plays an Important Role in Endoplasmic Reticulum Stress Response in both Cardiovascular and Metabolic System2007
- Author(s)
  Eguchi K, Manabe I, Shen H, Oishi Y, Fujiu K, Takeda N, Nishimura G, Nagai R.
- Organizer
  American Heart Association Scientific Sessions 2007
- Place of Presentation
  Orlando
- Year and Date
  2007-11-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390230

1. MANABBE Ichiro (70359628)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
2. FUJIU Katsuhito (30422306)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. NAGAI Ryozo (60207975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 大石由美子 (80435734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

NISHIMURA Go 西村 剛

Research Projects

Research Products

Co-Researchers

Analysis of the transcriptional control mechanism which regulates generation, development and disease of cardiovascular systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ER stress and posttranslational modification pathways in cardiometabolic syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

高機能ナノ粒子を用いた不安定プラークの診断=治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the transcriptional control mechanism which regulates cell differentiation and phenotype alteration in vascular diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

高機能ナノ粒子によるsiRNA治療法・分子イメージング法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transcription factor networks in blood vessel-metabolic system crosstalk and metabolic syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload.2010

Author(s)

Journal Title

Data Source

[Journal Article] FGF-2-induced HGF secretion by adipose-derived stromal cells inhibits post-injury fibrogenesis through a JNK-dependent mechanism.2009

Author(s)

Journal Title

Data Source

[Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.2009

Author(s)

Journal Title

Data Source

[Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.2009

Author(s)

Journal Title

Data Source

[Journal Article] A nanoparticle system specifically designed to deliver siRNA inhibits tumor growth in vivo.2009

Author(s)

Journal Title

Data Source

[Journal Article] In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] In vivo imaging revealed local cell dynamics in obese adipose tissue inflammation2008

Author(s)

Journal Title

Data Source

[Journal Article] In vivo imaging in mice reveals local cell dynamics and inflammation inobese adipose tissue.2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels2007

NISHIMURA Go 西村剛