Yoshifuji Hajime 吉藤元

… Alternative Names

YOSHIFUJI Hajime 吉藤元

吉藤元ヨシフジハジメ

Less

Researcher Number	20422975
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 講師
Affiliation (based on the past Project Information) *help	2020 – 2023: 京都大学, 医学研究科, 講師 2019: 京都大学, 医学研究科, 助教 2018: 京都大学, 医学研究科, 病院講師 2018: 京都大学, 大学院医学研究科, 助教 2017: 京都大学, 医学(系)研究科(研究院), 助教 … More 2015: 京都大学, 大学院医学研究科, 助教 2011 – 2015: 京都大学, 医学(系)研究科(研究院), 助教 2012: 京都大学, 大学院・医学研究科臨床免疫学, 助教 2007: Kyoto University, 医学研究科, 助教 2006: 京都大学, 医学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Collagenous pathology/Allergology / Basic Section 54020:Connective tissue disease and allergy-related
Keywords	Principal Investigator 膠原病学 / 全身性エリテマトーデス / チミジル酸シンターゼ / B細胞 / 疾患動物モデル / 動物モデル / T細胞 / 形質細胞 / MRL/lprマウス / IgGサブクラス … More / モデルマウス / IgG4関連疾患 / IgG4 / サイトカイン / 一塩基多型 / IL-12 / iPS細胞 / 高安動脈炎 / BAFF / 自己反応性細胞 / 抗DNA抗体 / ミオシン誘発筋炎 / カルパイン / 免疫学 … More Except Principal Investigator 免疫抑制療法 / 間質性肺炎 / 無筋症性皮膚筋炎 / 皮膚筋炎 / 自己抗体 / IFIH1 / MDA5 / サイトカイン / 亜型解析 / 遺伝学的解析 / 疾患レジストリ / 難病プラットフォーム / 疾患活動性指標 / GWAS / クラスター解析 / ゲノム解析 / レジストリ / 予後不良病型 / 疾患活動性 / レジストリ研究 / ベーチェット病 / 間質性肺病変 / DDB1 / 血漿交換療法 / SFPQ / 難治性病態 / 治療 / モデルマウス / 膠原病難治性病態 Less

Role of thymidylate synthetase in B cells of systemic lupus erythematosusPrincipal Investigator
- Principal Investigator
  
  吉藤元
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kyoto University
Improvement of IgG4-related disease model and its treatmentsPrincipal Investigator
- Principal Investigator
  
  Yoshifuji Hajime
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kyoto University
Generation of evidence through registry construction by genome-wide subtype analysis of Behcet's disease
- Principal Investigator
  
  KIRINO Yohei
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Yokohama City University
Approach to understanding of pathogenesis and invention of new treatments from the results of preliminary genetic studiesPrincipal Investigator
- Principal Investigator
  
  Yoshifuji Hajime
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kyoto University
Autoantibodies in dermatomyositis-associated interstitial lung disease and establishment of treatment for improved life prognosis
- Principal Investigator
  
  MImori Tsuneyo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kyoto University
Approach to regulation of an anti-DNA antibody-knock-in mouse nephritis modelPrincipal Investigator
- Principal Investigator
  
  Yoshifuji Hajime
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kyoto University
Study for pathological significance of autoantibodies and establishment of therapy in myositis-associated intractable acute interstitial pneumonia
- Principal Investigator
  
  MIMORI Tsuneyo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kyoto University
Regulation of autoreactive B cells in an anti-DNA antibody- knock-in mouse modelPrincipal Investigator
- Principal Investigator
  
  YOSHIFUJI Hajime
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyoto University
多発性筋炎・皮膚筋炎モデルを用いた筋炎病態解析とプロテアーゼ制御による治療法開発Principal Investigator
- Principal Investigator
  
  吉藤元
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyoto University

All 2023 2021 2020 2019 2018 2017 2016 2014 2013 2012 2011 2008 2007 2006

All Journal Article Presentation

[Journal Article] Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model2023
- Author(s)
  Gon Yoshie、Kandou Tsugumitsu、Tsuruyama Tatsuaki、Iwasaki Takeshi、Kitagori Koji、Murakami Kosaku、Nakashima Ran、Akizuki Shuji、Morinobu Akio、Hikida Masaki、Mimori Tsuneyo、Yoshifuji Hajime
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 2 Pages: e0279389-e0279389
- DOI
  10.1371/journal.pone.0279389
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08801
[Journal Article] Expression of S100A8 protein on B cells is associated with disease activity in patients with systemic lupus erythematosus2023
- Author(s)
  Kitagori Koji、Oku Takuma、Wakabayashi Masaki、Nakajima Tomoya、Nakashima Ran、Murakami Kosaku、Hirayama Yoshitaka、Ishihama Yasushi、Ohmura Koichiro、Morinobu Akio、Mimori Tsuneyo、Yoshifuji Hajime
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 25 Issue: 1 Pages: 76-76
- DOI
  10.1186/s13075-023-03057-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07893, KAKENHI-PROJECT-20K08485
[Journal Article] IgG4関連疾患のモデル動物と病因2020
- Author(s)
  吉藤元
- Journal Title
  
  炎症と免疫
  
  Volume: 28 Pages: 315-320
- Data Source
  KAKENHI-PROJECT-20K08801
[Journal Article] 【特集-リウマチ性疾患における遺伝素因と環境要因】　血管炎と遺伝子多型2019
- Author(s)
  吉藤元
- Journal Title
  
  リウマチ科
  
  Volume: 61 Pages: 122-7
- Data Source
  KAKENHI-PROJECT-17K09975
[Journal Article] 【血管炎症候群のupdate】　高安動脈炎のゲノム遺伝学的研究と生物学的製剤の有効性2019
- Author(s)
  吉藤元, 寺尾知可史
- Journal Title
  
  リウマチ科
  
  Volume: 61 Pages: 523-9
- Data Source
  KAKENHI-PROJECT-17K09975
[Journal Article] Pathophysiology of large vessel vasculitis and utility of interleukin-6 inhibition therapy.2019
- Author(s)
  Yoshifuji H
- Journal Title
  
  Mod Rheumatol
  
  Volume: 29 Issue: 2 Pages: 287-293
- DOI
  10.1080/14397595.2018.1546358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09975
[Journal Article] Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis.2018
- Author(s)
  Terao C, Yoshifuji H, Matsumura T, Naruse TK, Ishii T, Nakaoka Y, Kirino Y, Matsuo K, Origuchi T, Shimizu M, Maejima Y, Amiya E, Tamura N, Kawaguchi T, Takahashi M, Setoh K, Ohmura K, Watanabe R, Horita T, Atsumi T, Matsukura M, Miyata T, et al.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 115 Issue: 51 Pages: 13045-13050
- DOI
  10.1073/pnas.1808850115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09975, KAKENHI-PROJECT-16H05298, KAKENHI-PROJECT-18H02926, KAKENHI-PROJECT-16H06277
[Journal Article] Splicing factor proline/glutamine-rich is a novel autoantigen of dermatomyositis and associated with anti-melanoma differentiation-associated gene 5 antibody.2017
- Author(s)
  Hosono Y, Nakashima R, Serada S, Murakami K, Imura Y, Yoshifuji H, Ohmura K, Naka T, Mimori T
- Journal Title
  
  J Autoimmun.
  
  Volume: 77 Pages: 116-122
- DOI
  10.1016/j.jaut.2016.11.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05341
[Journal Article] A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production.2017
- Author(s)
  Nakajima T, Yoshifuji H, Shimizu M, Kitagori K, Murakami K, Nakashima R, Imura Y, Tanaka M, Ohmura K, Matsuda F, Terao C, Mimori T.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 19 Issue: 1 Pages: 197-197
- DOI
  10.1186/s13075-017-1408-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09975
[Journal Article] Two cases of autoimmune and secondary pulmonary alveolar proteinosis during immunosuppressive therapy in dermatomyositis with interstitial lung disease.2016
- Author(s)
  Imura Y, Yukawa N, Handa T, Nakashima R, Murakami K, Yoshifuji H, Ohmura K, Ishii H, Nakata K, Mimori T:
- Journal Title
  
  Mod Rheumatol. [Epub ahead of print]
  
  Volume: 00 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293222
[Journal Article] Serum milk fat globule epidermal growth factor 8 elevation may subdivide systemic lupus erythematosus into two pathophysiologically distinct subsets2014
- Author(s)
  Yamamoto, N., Yamaguchi, H., Ohmura, K., Yokoyama, T., Yoshifuji, H., Yukawa, N., Kawabata, D., Fujii, T., Morita, S., Nagata, S. and Mimori, T.
- Journal Title
  
  Lupus
  
  Volume: 23 Issue: 4 Pages: 386-394
- DOI
  10.1177/0961203314523870
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22000013, KAKENHI-PROJECT-25461472, KAKENHI-PROJECT-25461473, KAKENHI-PROJECT-26460649
[Journal Article] Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL-6 and IL-8.2014
- Author(s)
  Shiheido H, Kitagori K, Sasaki C, Kobayashi S, Aoyama T, Urata K, Oku T, Hirayama Y, Yoshitomi H, Hikida M, Yoshifuji H, Mimori T, Watanabe T, Shimizu J.
- Journal Title
  
  Immunity, Inflammation and Disease.
  
  Volume: 2 Issue: 1 Pages: 35-43
- DOI
  10.1002/iid3.17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111009, KAKENHI-PROJECT-25461473
[Journal Article] SLEモデルマウスにおける自己反応性B細胞制御メカニズム2012
- Author(s)
  吉藤　元
- Journal Title
  
  リウマチ科
  
  Volume: 48 Pages: 246-52
- Data Source
  KAKENHI-PROJECT-23791111
[Journal Article] Serum BAFF and APRIL levels in patients with IgG4-related disease and their clinical significance.2012
- Author(s)
  Kiyama K, Kawabata D, Hosono Y, Kitagori K, Yukawa N, Yoshifuji H, Ohmura K, Fujii T, Mimori T
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 14(2) Issue: 2
- DOI
  10.1186/ar3810
- NAID
  120004754361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390201, KAKENHI-PROJECT-22591091, KAKENHI-PROJECT-23791111, KAKENHI-PROJECT-23791112
[Journal Article] SLE モデルマウスにおける自己反応性 B 細胞制御メカニズム2012
- Author(s)
  吉藤元.
- Journal Title
  
  リウマチ科
  
  Volume: 48 Pages: 246-52
- Data Source
  KAKENHI-PROJECT-23791111
[Journal Article] Antigen is required for maturation and activation of pathogenic anti-DNA antibodies and systemic inflammation.2011
- Author(s)
  Venkatesh J, Yoshifuji H, Kawabata D, Chinnasamy P, Stanevsky A, Grimaldi CM, Cohen-Solal J, Diamond B.
- Journal Title
  
  J Immunol
  
  Volume: 186 Issue: 9 Pages: 5304-12
- DOI
  10.4049/jimmunol.1000224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791111
[Journal Article] 抗アミノアシルtRNA合成酵素抗体症候群2008
- Author(s)
  吉藤元, 三森経世
- Journal Title
  
  臨床検査 52
- Data Source
  KAKENHI-PROJECT-18790679
[Journal Article] 多発性筋炎・皮膚筋炎自己抗体に関する最新のトピックス2006
- Author(s)
  吉藤元, 三森経世
- Journal Title
  
  Medicine 43巻第6号
  
  Pages: 935-937
- Data Source
  KAKENHI-PROJECT-18790679
[Presentation] 【シンポジウム3: IgG4関連疾患の病因・病態と治療】ヒトIgG4ノックインマウスの検討.2021
- Author(s)
  吉藤元，権淳英.
- Organizer
  日本シェーグレン症候群学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08801
[Presentation] 【近未来のリウマチ医セッション】　希少疾患研究のすすめ　－高安動脈炎の遺伝子研究－2019
- Author(s)
  吉藤元
- Organizer
  日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-17K09975
[Presentation] 【教育講演3　血管炎】　ポリジーンから見た大型血管炎の病態と治療.2018
- Author(s)
  吉藤元.
- Organizer
  日本リウマチ学会中国・四国支部学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09975
[Presentation] 高安動脈炎の新規関連領域及びHLAとLILRA3領域の相互作用の同定.2018
- Author(s)
  寺尾知可史, 吉藤元, 松村貴由, 成瀬妙子, 石井智徳, 小室一成, 木村彰方, 磯部光章, 三森経世, 松田文彦.
- Organizer
  日本内科学会
- Data Source
  KAKENHI-PROJECT-17K09975
[Presentation] Genetic Backgrounds and Pathophysiology of Large Vessel Vasculitis.2018
- Author(s)
  吉藤元
- Organizer
  日本循環器学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09975
[Presentation] The SNP rs6871626 Located in IL12B Region may Influence on Vascular Lesions of Takayasu Arteritis.2017
- Author(s)
  Nakajima T, Yoshifuji H, Terao C, Murakami K, Nakashima R, Imura Y, Ohmura K, Mimori T.
- Organizer
  欧州リウマチ学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09975
[Presentation] 高安動脈炎の遺伝学的要因と治療応用2017
- Author(s)
  吉藤元
- Organizer
  日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-17K09975
[Presentation] Predictive factors of poor prognosis and utility of plasmaexchange in anti-MDA5(+)dermatomyositis with interstitial lung disease under immunosuppressive therapy.2016
- Author(s)
  Mirei Shirakashi, Ran Nakashima, Yuji Hosono, Kosaku Murakami, Motomu Hashimoto, Naoichiro Yukawa, Yoshitaka Imura, Hajime Yoshifuji, Masao Tanaka, Koichiro Ohmura, Tsuneyo Mimori
- Organizer
  The 13th International Workshop on Autoantibodies and Autoimmunity
- Place of Presentation
  Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05341
[Presentation] Splicing Factor Proline/Glutamine-Rich Is a Novel Autoantigen of Dermatomyositis and Associated with Anti-Melanoma Differentiation-Associated Gene 5 Antibody.2016
- Author(s)
  Yuji Hosono, Ran Nakashima, Kosaku Murakami, Yoshitaka Imura, Satoshi Serada, Minoru Fujimoto, Hajime Yoshifuji, Koichiro Ohmura, Tetsuji Naka and Tsuneyo Mimori.
- Organizer
  American College of Rheumatology2016/9/28
- Place of Presentation
  Washington, DC
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05341
[Presentation] The onset of myositis with myositis-specific autoantibodies (MSAs) are associated with the seasons.2013
- Author(s)
  Hosono Y, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Hashimoto M, Ohmura K, Fujii T, Mimori T
- Organizer
  EULAR2013 (European League Against Rheumatism)
- Place of Presentation
  Madrid, Spain
- Data Source
  KAKENHI-PROJECT-25293222
[Presentation] SLE モデルマウスにおける自己反応性 B 細胞制御メカニズム.2011
- Author(s)
  吉藤元
- Organizer
  第10回リウマチ膠原病・よつやセミナー
- Place of Presentation
  ベルサール八重洲(東京)(招待講演)
- Year and Date
  2011-08-27
- Data Source
  KAKENHI-PROJECT-23791111
[Presentation] SLEモデルマウスにおける自己反応性B細胞制御メカニズム2011
- Author(s)
  吉藤　元
- Organizer
  第10回　リウマチ膠原病・よつやセミナー(招待講演)
- Place of Presentation
  ベルサール八重洲（東京）
- Data Source
  KAKENHI-PROJECT-23791111
[Presentation] Amelioration of Experimental Myopathyby a Calpain-inhibitory Compound2007
- Author(s)
  吉藤元, 臼井崇, ほか
- Organizer
  米国リウマチ学会
- Place of Presentation
  米国ボストン
- Year and Date
  2007-11-10
- Data Source
  KAKENHI-PROJECT-18790679

1. OMURA Koichiro (40432372)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. MIMORI Tsuneyo (10157589)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. IMURA Yoshitaka (60456895)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. NAKASHIMA Ran (10599525)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. TERAO Chikashi (60610459)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. FUJII Takao (70255462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. YUKAWA Naoichiro (90422972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. MURAKAMI Kousaku (70599927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. KIRINO Yohei (50468154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 小林大介 (00363507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 渥美達也 (20301905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 國崎玲子 (20457849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中島秀明 (30217723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 田中良哉 (30248562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 岳野光洋 (50236494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 土橋浩章 (50380176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 目黒明 (60508802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 黒沢美智子 (70245702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 東野俊洋 (70458818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 吉見竜介 (70585265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 藤枝雄一郎 (70790872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 菊地弘敏 (80338681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 竹内正樹 (80794081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 廣畑俊成 (90189895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 川上純 (90325639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 水木信久 (90336579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 古賀智裕 (90537284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 宮川一平 (10525463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. HOSONO Yuji

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
30. TSUJI Hideki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
31. YAGITA Nasato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. HATTA Kazuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. NOJIMA Takaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. KATAYAMA Masaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 長田重一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 藤井俊裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 渡辺武

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshifuji Hajime 吉藤 元

YOSHIFUJI Hajime 吉藤 元

吉藤 元 ヨシフジ ハジメ

Research Projects

Research Products

Co-Researchers

Role of thymidylate synthetase in B cells of systemic lupus erythematosusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Improvement of IgG4-related disease model and its treatmentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation of evidence through registry construction by genome-wide subtype analysis of Behcet's disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Approach to understanding of pathogenesis and invention of new treatments from the results of preliminary genetic studiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Autoantibodies in dermatomyositis-associated interstitial lung disease and establishment of treatment for improved life prognosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Approach to regulation of an anti-DNA antibody-knock-in mouse nephritis modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for pathological significance of autoantibodies and establishment of therapy in myositis-associated intractable acute interstitial pneumonia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of autoreactive B cells in an anti-DNA antibody- knock-in mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

多発性筋炎・皮膚筋炎モデルを用いた筋炎病態解析とプロテアーゼ制御による治療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of S100A8 protein on B cells is associated with disease activity in patients with systemic lupus erythematosus2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IgG4関連疾患のモデル動物と病因2020

Author(s)

Journal Title

Data Source

[Journal Article] 【特集-リウマチ性疾患における遺伝素因と環境要因】 血管炎と遺伝子多型2019

Author(s)

Journal Title

Data Source

[Journal Article] 【血管炎症候群のupdate】 高安動脈炎のゲノム遺伝学的研究と生物学的製剤の有効性2019

Author(s)

Yoshifuji Hajime 吉藤元

YOSHIFUJI Hajime 吉藤元

吉藤元ヨシフジハジメ

[Journal Article] 【特集-リウマチ性疾患における遺伝素因と環境要因】　血管炎と遺伝子多型2019

[Journal Article] 【血管炎症候群のupdate】　高安動脈炎のゲノム遺伝学的研究と生物学的製剤の有効性2019

[Journal Article] 多発性筋炎・皮膚筋炎自己抗体に関する最新のトピックス2006

[Presentation] 【近未来のリウマチ医セッション】　希少疾患研究のすすめ　－高安動脈炎の遺伝子研究－2019