YAMASHITA Takenari 山下雄也

Researcher Number	20431843
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2019: 東京医科大学, 医学部, 客員研究員 2016 – 2017: 東京大学, 大学院医学系研究科(医学部), 特任研究員 2015: 東京大学, 医学(系)研究科(研究院), 特任研究員 2014: 東京大学, 医学(系)研究科(研究院), 研究員 2013: 東京大学, 医学(系)研究科(研究院), 特任研究員 … More 2012: 東京大学, 医学(系)研究科(研究院), 研究員 2012: 東京大学, 大学院・医学系研究科, 特任研究員 2011: 東京大学, 医学部附属病院, 特任研究員 2008: The University of Tokyo, 医学部附属病院, リサーチ・フェロー 2007 – 2008: The University of Tokyo, 医学部附属病院, リサーチフェロー 2007: 東京大学, 医学部・附属病院, リサーチフェロー Less
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator AMPA受容体 / 筋萎縮性側索硬化症 / RNA編集 / ADAR2 / カルパイン / 神経細胞死 / GluA2 / TDP-43 / AMPA 受容体 / 細胞死 … More / ALS / 核ー細胞死輸送 / 核膜孔複合体（NPC） / 核-細胞質輸送 / 核膜孔複合体 / 核‐細胞質輸送 / NPC / FUS / RNA結合蛋白 / calpain / リン酸化 / カルシウム / Calpain / RNA 編集 / microRNA … More Except Principal Investigator 脊髄運動ニューロン / 動物モデル / ADAR2 / GluR2 / RNA編集 / AMPA受容体 / グルタミン酸受容体 / 筋萎縮性側索硬化症 / 脳神経疾患 Less

Ca2+流入異常を介した核-細胞質システム破綻による細胞死メカニズムの解析Principal Investigator
- Principal Investigator
  
  山下雄也
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical University
  The University of Tokyo
Analysis of the molecular link of amyotrophic lateral sclerosis associated genes in sporadic ALS model micePrincipal Investigator
- Principal Investigator
  
  Yamashita Takenari
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo
Analysis of cascade of neuronal cell death for TDP-43 in sporadic amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Takenari
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo
Search for microRNA capable of modifying with ADAR2 activityPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Takenari
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo
ALS運動ニューロンにおけるGLUR2RNA編集異常の解析
- Principal Investigator
  
  KWAK Shin
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 2008 2007 Other

All Journal Article Presentation Book Other

[Book] 遺伝子医学MOOK 30号2016
- Author(s)
  山下雄也, 郭　伸
- Publisher
  株式会社　メディカル　ドゥ
- Data Source
  KAKENHI-PROJECT-25461269
[Book] AMPA receptor-mediated neuronal death in motor neuron diseases. In: Amino Acid Receptor Research, Eds. Paley BF, Warfield TE2008
- Author(s)
  Kwak S, Hideyama T, Yamashita T
- Publisher
  Nova Science Publishers Inc. NY.
- Data Source
  KAKENHI-PROJECT-19790601
[Book] In Amino Acid Receptor Research (AMPA receptor-mediated neuronal death in motor neuron diseases)2008
- Author(s)
  Kwak S., Hideyama T., Yamashita T
- Publisher
  Nova Science Publishers Inc. NY
- Data Source
  KAKENHI-PROJECT-19790601
[Book] グルタミン酸受容体と神経細胞死、神経変性疾患のサイエンス2007
- Author(s)
  山下雄也, 郭伸
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-19790601
[Book] 神経変性疾患のサイエンス(グルタミン酸受容体と神経細胞死)2007
- Author(s)
  山下雄也, 郭伸
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-19790601
[Book] 神経変性疾患のサイエンス(神経細胞死とグルタミン酸受容体)2007
- Author(s)
  山下雄也、郭伸
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-18023012
[Journal Article] Extracellular RNAs as Biomarkers of Sporadic Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases.2019
- Author(s)
  Hosaka T, Yamashita T, Tamaoka A, Kwak S.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20 Issue: 13 Pages: 3148-3148
- DOI
  10.3390/ijms20133148
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23957, KAKENHI-PROJECT-16K09666, KAKENHI-PROJECT-16H06277
[Journal Article] Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein.2019
- Author(s)
  Aizawa H, Yamashita T, Kato H, Kimura T, Kwak S
- Journal Title
  
  J Clin Neurol.
  
  Volume: 15（1） Issue: 1 Pages: 62-67
- DOI
  10.3988/jcn.2019.15.1.62
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09666, KAKENHI-PROJECT-18K07537, KAKENHI-PROJECT-16H06277
[Journal Article] ADAR2-dependent A-to-I RNA editing in the extracellular linear and circular RNAs.2018
- Author(s)
  Hosaka T, Yamashita T, Teramoto S, Hirose N, Tamaoka A, Kwak S
- Journal Title
  
  Neurosci Res.
  
  Volume: 印刷中 Pages: 48-57
- DOI
  10.1016/j.neures.2018.11.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09666, KAKENHI-PROJECT-16K09681, KAKENHI-PROJECT-16H06277
[Journal Article] Cell death cascade and molecular therapy in ADAR2-deficient motor neurons of ALS.2018
- Author(s)
  Yamashita T, Kwak S
- Journal Title
  
  Neurosci Res.
  
  Volume: 印刷中 Pages: 4-13
- DOI
  10.1016/j.neures.2018.06.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09666, KAKENHI-PROJECT-16K09681, KAKENHI-PROJECT-16H06277
[Journal Article] Altered intracellular milieu of ADAR2-deficient motor neurons in amyotrophic lateral sclerosis2017
- Author(s)
  Yamashita T, Akamatsu M, Kwak S
- Journal Title
  
  Genes
  
  Volume: 8(2)-60 Issue: 2 Pages: 60-60
- DOI
  10.3390/genes8020060
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253063, KAKENHI-PROJECT-16K09666, KAKENHI-PROJECT-17K09747
[Journal Article] Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons.2017
- Author(s)
  Yamashita T, Aizawa H, Teramoto S, Akamatsu M, Kwak S
- Journal Title
  
  Sci Reports
  
  Volume: 7-39994 Issue: 1
- DOI
  10.1038/srep39994
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253063, KAKENHI-PROJECT-16K09666, KAKENHI-PROJECT-17K09747
[Journal Article] 孤発性ALSの病態と治療－AMPA受容体阻害薬による筋萎縮性側索硬化症治療の可能性2017
- Author(s)
  赤松恵, 山下雄也, 郭　伸
- Journal Title
  
  神経治療学
  
  Volume: 34-2 Pages: 86-94
- Open Access
- Data Source
  KAKENHI-PROJECT-16K09666
[Journal Article] Phosphorylated TDP-43 becomes resistant to cleavage by calpain: a regulatory role for phosphorylation in TDP-43 pathology of ALS/FTLD.2016
- Author(s)
  Yamashita T, Teramoto S, Kwak S
- Journal Title
  
  Neurosci Res
  
  Volume: 未定 Pages: 63-69
- DOI
  10.1016/j.neures.2015.12.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461266, KAKENHI-PROJECT-25461269, KAKENHI-PROJECT-25253063, KAKENHI-PROJECT-16K09666
[Journal Article] Abnormal RNA editing and treatment strategy in neurological diseases; towards cure for ALS2016
- Author(s)
  山下雄也, 郭　伸
- Journal Title
  
  生化学
  
  Volume: 88 Issue: 5 Pages: 600-608
- DOI
  10.14952/SEIKAGAKU.2016.880600
- ISSN
  0037-1017
- Year and Date
  2016-10-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-16K09666
[Journal Article] 特集認知症･神経変性疾患の克服への挑戦 Ⅲ.新たな技術開発によるチャレンジ ALSの遺伝子治療─分子病態解明から治療へ2016
- Author(s)
  山下雄也, 郭　伸
- Journal Title
  
  生体の科学
  
  Volume: 67 Issue: 4 Pages: 323-328
- DOI
  10.11477/mf.2425200462
- ISSN
  0370-9531, 1883-5503
- Year and Date
  2016-08-15
- Data Source
  KAKENHI-PROJECT-16K09666
[Journal Article] Deficient RNA-editing enzyme ADAR2 in an amyotrophic lateral sclerosis patient with a FUSP525L mutation.2016
- Author(s)
  Aizawa H, Hideyama T, Yamashita T, Kimura T, Suzuki N, Aoki M, Kwak S
- Journal Title
  
  J Clin Neurosci
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461269
[Journal Article] 筋萎縮性側索硬化症－孤発性ALSモデルマウスを用いたALSの遺伝子治療法開発2016
- Author(s)
  山下雄也, 郭　伸
- Journal Title
  
  遺伝子医学 MOOK
  
  Volume: 30 Pages: 257-263
- Data Source
  KAKENHI-PROJECT-16K09666
[Journal Article] The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice.2016
- Author(s)
  Akamatsu M, Yamashita T, Hirose N, Teramoto S, Kwak S:
- Journal Title
  
  Sci Rep
  
  Volume: 7-28649 Issue: 1
- DOI
  10.1038/srep28649
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253063, KAKENHI-PROJECT-16K09666
[Journal Article] Deficient RNA-editing enzyme ADAR2 in an amyotrophic lateral sclerosis patient with a FUSP525L mutation2016
- Author(s)
  Aizawa H, Hideyama T, Yamashita T, Kimura T, Suzuki N, Aoki M, Kwak S
- Journal Title
  
  J Clin Neurosci
  
  Volume: 32 Pages: 128-129
- DOI
  10.1016/j.jocn.2015.12.039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253063, KAKENHI-PROJECT-15H05667, KAKENHI-PROJECT-16K09666
[Journal Article] Autophagy in spinal motor neurons of conditional ADAR2-knockout mice: an implication for a role of calcium in increased autophagy flux in ALS.2015
- Author(s)
  Sasaki S, Yamashita T, Kwak S
- Journal Title
  
  Neurosci Lett
  
  Volume: 598 Pages: 79-84
- DOI
  10.1016/j.neulet.2015.05.025
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461269
[Journal Article] TDP-43病理形成メカニズム2014
- Author(s)
  山下雄也, 郭　伸
- Journal Title
  
  Dementia Japan
  
  Volume: 28 Pages: 307-318
- Data Source
  KAKENHI-PROJECT-25461269
[Journal Article] Unique nuclear vacuoles in the motor neurons of conditional ADAR2-knockout mice2014
- Author(s)
  Sasaki S, Yamashita T, Hideyama T, Kwak S
- Journal Title
  
  Brain Research
  
  Volume: 1550 Pages: 36-46
- DOI
  10.1016/j.brainres.2014.01.006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22590965, KAKENHI-PUBLICLY-25110709, KAKENHI-PROJECT-25253063, KAKENHI-PROJECT-25461269, KAKENHI-PROJECT-26640036
[Journal Article] The molecular link between inefficient GluA2 Q/R site-RNA editing and TDP-43 pathology in motor neurons of sporadic amyotrophic lateral sclerosis patients.2014
- Author(s)
  Yamashita, T., and Kwak, S.
- Journal Title
  
  Brain Res.
  
  Volume: in press. Pages: 28-38
- DOI
  10.1016/j.brainres.2013.12.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25110709, KAKENHI-PROJECT-25253063, KAKENHI-PROJECT-25461269, KAKENHI-PROJECT-26640036
[Journal Article] Calpain plays a crucial role in TDP-43 pathology2014
- Author(s)
  山下雄也, 郭　伸
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 54 Issue: 12 Pages: 1151-1154
- DOI
  10.5692/clinicalneurol.54.1151
- NAID
  130004921169
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-25461269
[Journal Article] RNA editingと筋萎縮性側索硬化症。RNA　Biologyからみた神経変性疾患の病態機序2013
- Author(s)
  山下雄也、郭　伸
- Journal Title
  
  医学の歩み
  
  Volume: 247 Pages: 412-420
- Data Source
  KAKENHI-PROJECT-25461269
[Journal Article] A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation.2013
- Author(s)
  Akamatsu, M., Takuma, H., Yamashita, T., Okada, T., Keino-Masu, K., Ishii, K., Kwak, S., Masu, M., and Tamaoka, A.
- Journal Title
  
  Neuroscience Research
  
  Volume: 77 Issue: 4 Pages: 234-241
- DOI
  10.1016/j.neures.2013.09.009
- NAID
  120007130577
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22123006, KAKENHI-PUBLICLY-24110502, KAKENHI-PROJECT-24591249, KAKENHI-PUBLICLY-25110709, KAKENHI-PROJECT-25253063, KAKENHI-PROJECT-25293065, KAKENHI-PROJECT-25461266, KAKENHI-PROJECT-25461269
[Journal Article] Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons2013
- Author(s)
  Yamashita T, Chai HL, Teramoto S, Tsuji S, Shimazaki K, Muramatsu S, Kwak S
- Journal Title
  
  EMBO Mol Med
  
  Volume: 5(11) Issue: 11 Pages: 1710-1719
- DOI
  10.1002/emmm.201302935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590473, KAKENHI-PUBLICLY-25110709, KAKENHI-PUBLICLY-25110729, KAKENHI-PROJECT-25253063, KAKENHI-PROJECT-25461269
[Journal Article] Profound downregulation of the RNA editing enzyme ADAR2 in ALS motor neurons2012
- Author(s)
  Hideyama T, Yamashita Y, H Aizawa, Tsuji S,Kakita A, Takahashi H, Kwak S
- Journal Title
  
  Neurobiol Dis
  
  Volume: 45 Issue: 3 Pages: 1121-1128
- DOI
  10.1016/j.nbd.2011.12.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390173, KAKENHI-PROJECT-23659184, KAKENHI-PROJECT-23790977, KAKENHI-PUBLICLY-23110503
[Journal Article] Abnormal processing of TDP-43 does not regulate ADAR2 activity in cultured cell lines2012
- Author(s)
  Yamashita T, Hideyama T, Teramoto S, Kwak S
- Journal Title
  
  Neurosci Res
  
  Volume: 73 Issue: 2 Pages: 153-160
- DOI
  10.1016/j.neures.2012.02.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390173, KAKENHI-PROJECT-23790977
[Journal Article] RNA editing of the Q/R site of GluA2 in cultured cell lines expressing different levels of the RNA editing enzyme ADAR22012
- Author(s)
  Yamashita T, Tadami C, Nishimoto Y, Hideyama T, Kimura D, Suzuki T,Kwak S
- Journal Title
  
  Neurosci Res
  
  Volume: 73 Issue: 1 Pages: 42-48
- DOI
  10.1016/j.neures.2012.02.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390173, KAKENHI-PROJECT-23790977, KAKENHI-PROJECT-23791002, KAKENHI-PUBLICLY-23110503
[Journal Article] Co-occurrence of TDP-43 mislocalization with reduced RNA editing enzyme, ADAR2, in aged mouse motor neurons: implications for age-related acceleration of ALS2012
- Author(s)
  Hideyama T, Teramoto S, Hachiga K, Yamashita T, Kwak S
- Journal Title
  
  PLoS One
  
  Volume: 7,(8) Issue: 8 Pages: e43469-e43469
- DOI
  10.1371/journal.pone.0043469
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390173, KAKENHI-PROJECT-23790977, KAKENHI-PROJECT-23790978
[Journal Article] A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology2012
- Author(s)
  Yamashita T, Hideyama T, Hachiga K, Teramoto S, Takano J, Iwata N, Saido TC, and Kwak S
- Journal Title
  
  Nat Commun
  
  Volume: 3 Issue: 1 Pages: 1307-1307
- DOI
  10.1038/ncomms2303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390173, KAKENHI-PROJECT-22700379, KAKENHI-PROJECT-23790977, KAKENHI-PUBLICLY-23110535
[Journal Article] Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line.2009
- Author(s)
  Sawada J, Yamashita T, Aizawa H, Aburakawa Y, Hasebe N, Kwak S
- Journal Title
  
  Neurosci. Res. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790601
[Journal Article] Determination of editors at the novel A-to-I editing positions2008
- Author(s)
  Nishimoto Y., Yamashita T., Hideyama T., Tsuji S. Suzuki N., Kwak S.
- Journal Title
  
  Neuroscience Research (掲載確定)
- Data Source
  KAKENHI-PROJECT-19790601
[Journal Article] Determination of editors at the novel A-to-I editing positions2008
- Author(s)
  Nishimoto Y., Yamashita T., Hideyama T., Tsuji S., Suzuki N., Kwak S.
- Journal Title
  
  Neuroscience Research 61
  
  Pages: 201-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790601
[Journal Article] Newly identified ADAR2-mediated editing positions as a useful tool for ALS research2008
- Author(s)
  Kwak S., Nishimoto Y., Yamashita T.
- Journal Title
  
  RNA Biology 5
  
  Pages: 193-197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790601
[Journal Article] Determination of editors at the novel A-to-I editing positions2008
- Author(s)
  Nishimoto Y, Yamashita T, Hideyama T, Tsuji S, Suzuki N, Kwak S
- Journal Title
  
  Neurosci. Res. 61(2)
  
  Pages: 201-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790601
[Journal Article] Newly identified ADAR2-mediated editing positions as a useful tool for ALS research.2008
- Author(s)
  Kwak S, Nishimoto Y, Yamashita T
- Journal Title
  
  RNA Biology 5
  
  Pages: 193-197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790601
[Journal Article] Determination of editors of mRNAs with site-selective-A-to-1 editing positions.2008
- Author(s)
  Nishimoto Y, Yamashita T, Hideyama T, Tsuji S, Suzuki N, Kwak S
- Journal Title
  
  Neurosci Res 61
  
  Pages: 201-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023012
[Journal Article] Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cellline
- Author(s)
  Sawada J., Yamashita T., Aizawa H., Aburakawa Y., Hasebe N., Kwak S.
- Journal Title
  
  Neuroscience Research (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] AMPA受容体サブユニット特異的RNAアプタマーによるALSモデルマウス（AR2）におけるALS病態の改善効果.2019
- Author(s)
  赤松恵, 山下雄也, 寺本さやか, Huang Zhen, 戸田達史, Niu Li,郭伸
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] ALSにおいて発現が低下するADAR2遺伝子の発現をヒト脊髄運動神経にて制御しうる転写因子の探索2019
- Author(s)
  廣瀬直毅,寺本さやか,山下雄也,郭伸
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] ADAR2-mediated RNA editing of extracellular liner and circular RNAs: a potential biomarker of amyotrophic lateral sclerosis.2018
- Author(s)
  Hosaka T, Yamashita T, Teramoto S, Hirose N, Tamaoka A, Kwak S
- Organizer
  The 49th Annual Meeting Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] ADAR2-mediated A-to-I sites in extracellular RNAs as a biomarker of amyotrophic lateral sclerosis2018
- Author(s)
  保坂孝史，山下雄也，寺本さやか，廣瀬直樹，玉岡晃，郭伸
- Organizer
  The 59th Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] ADAR2-dependent A-to-I RNA editing in the extracellular linear and circular RNAs.2018
- Author(s)
  Hosaka T, Yamashita T, Teramoto S, Hirose N, Tamaoka A, Kwak S
- Organizer
  Neurobiology of Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] Development of ALS therapy using AMPA receptor RNA aptamers.2018
- Author(s)
  Akamatsu M, Yamashita T, Teramoto S, Huang, Z, Niu L, Kwak S
- Organizer
  4th EAN Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] ALSにおいて発現が低下するADAR2遺伝子の発現制御メカニズムのヒト運動ニューロン特異性,2018
- Author(s)
  廣瀬直毅，寺本さやか，山下雄也，郭伸
- Organizer
  第41回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] Target therapy for ALS with RNA aptamers - rescue of ALS phenotype resulting from loss of motor neurons with TDP-43 pathology in ALS model mice.2018
- Author(s)
  Akamatsu M, Yamashita T, Teramoto S, Huang, Z, Niu L, Kwak S
- Organizer
  The 49th Annual Meeting Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] RNA aptamer as a potential drug candidate for ALS - rescue of clinicopathologic ALS phenotype in model mice.2018
- Author(s)
  Akamatsu M, Yamashita T, Teramoto S, Huang, Z, Niu L, Kwak S
- Organizer
  Neurobiology of Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] SEARCH FOR ALS-ASSOCIATED EXTRACELLULAR RNA AS A BIOMARKER2017
- Author(s)
  1.Takashi Hosaka, Takenari Yamashita, Naoki Hirose, Sayaka Teramoto, Akira Tamaoka, Shin Kwak
- Organizer
  WCN2017: XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] A selective non-competitive AMPA receptor antagonist as a potential drug for sporadic amyotrophic lateral sclerosis (ALS) -rescue of motor dysfunctions and loss of motor neurons with TDP-43 pathology in ALS model mice.2016
- Author(s)
  Megumi Akamatsu, Takenari Yamashita, Takashi Hosaka, Naoki Hirose, Sayaka Teramoto, Shin Kwak
- Organizer
  Society for Neuroscience 2016.
- Place of Presentation
  San Diego Convention Center（San Diego　USA）
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] 筋萎縮性側索硬化症の分子標的治療.2016
- Author(s)
  郭伸, 山下雄也, 赤松恵, 寺本さやか
- Organizer
  第34回日本神経治療学会】特別プログラム「シンポジウム3」
- Place of Presentation
  米子コンベンションセンター（鳥取県米子市）
- Year and Date
  2016-11-03
- Invited
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] 孤発性筋萎縮性側索硬化症の病因に基づいた特異治療法の確立.2016
- Author(s)
  山下雄也, 赤松恵、寺本さやか、村松慎一, 相澤仁志, 郭伸
- Organizer
  2015年度IBCグラント研究奨励金報告会
- Place of Presentation
  中央大学駿河台記念館610教室(東京都文京区)
- Year and Date
  2016-11-06
- Invited
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] Death of motor neurons caused by failure of GluA2 RNA editing was robustly rescued by a selective AMPA receptor antagonist in the mechanistic ALS model mice: a potential drug for sporadic amyotrophic lateral scleroses(ALS).2016
- Author(s)
  Megumi Akamatsu, Takenari Yamashita, Takashi Hosaka, Naoki Hirose, Sayaka Teramoto, Shin Kwak
- Organizer
  【4th RNA Metabolism in Neurological Disease】11th Brain Research Conference.
- Place of Presentation
  Paradise Point（San Diego　USA）
- Year and Date
  2016-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] ROBUST BENEFICIAL EFFECTS OF A NON-COMPETITIVE AMPA RECEPTOR ANTAGONIST IN AN ALS MOUSE MODEL.2016
- Author(s)
  Megumi Akamatsu, Takenari Yamashita, Sayaka Teramoto, Shin Kwak
- Organizer
  The 27th International Symposium on ALS/MND .
- Place of Presentation
  Convention Centre Dublin （Dublin　Ireland）
- Year and Date
  2016-12-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09666
[Presentation] AMPA受容体アンタゴニストであるランパネルを用いたALS治療法の開発2015
- Author(s)
  山下雄也, 廣瀬直己, 赤松恵, 寺本さやか, 蔡慧令, 郭伸
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場.兵庫県・神戸市
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] Mechanism-based gene therapy for sporadic ALS.2015
- Author(s)
  郭　伸, 山下雄也, 寺本さやか
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟コンベンションセンター). 新潟県・新潟市
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] ADAR2-dependent death and TDP-43 mislocalization in motor neurons.2013
- Author(s)
  Kwak S, Yamashita T, Teramoto S, Chai HL
- Organizer
  8th Brain Research conference “RNA binding proteins in neurological disease”
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] マウス胎仔電気穿孔法による in vivo TDP-43 遺伝子導入と封入体形成2013
- Author(s)
  11. 詫間浩、赤松恵、山下雄也、岡田拓也、石井一弘、桝和子、郭伸、桝正幸、玉岡晃
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京、日本
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] Calpain-dependent cleavage of TDP-43 plays a crucial role in ALS pathology.2013
- Author(s)
  4. Yamashita T, Hideyama T, Teramoto S, Takano J, Iwata N, Saido TC, Kwak S
- Organizer
  The 44th Annual Meeting Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] TDP-43 aggregation produced by In utero electroporation and its properties in the mouse motor neurons.2013
- Author(s)
  9. Akamatsu M, Takuma H, Yamashita T, Okada T, Ishii K, Keino-Masu K, Kwak S, Masu M, Tamaoka A
- Organizer
  The 44th Annual Meeting Society for Neuroscience
- Place of Presentation
  San Diego、USA
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] ClapainがALSのTDP-43病理形成に果たす役割2013
- Author(s)
  8. 山下雄也、日出山拓人、寺本さやか、高野二郎、岩田修永、西道隆臣、郭　伸
- Organizer
  第35回神経組織培養研究会
- Place of Presentation
  大阪、日本
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] ADAR2 plays a key role for death and TDP-43 mislocalization in ALS motor neurons.2013
- Author(s)
  Yamashita T, Teramoto S, Chai HL, Muramatsu SI, Kwak S
- Organizer
  The 24th International Symposium on MND/ALS
- Place of Presentation
  Milan, Itary
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] Molecular mechanism generating TDP-43 pathology in amyotrophic lateral sclerosis (ALS) motor neurones.2013
- Author(s)
  Kwak S, Yamashita T, Hideyama T, Teramoto S
- Organizer
  The 23rd Meeting of the European Neurological Society
- Place of Presentation
  Balcerona, Spain
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] ClapainがALSのTDP-43病理形成に重要な役割を果たす2013
- Author(s)
  7. 山下雄也、日出山拓人、寺本さやか、高野二郎、岩田修永、西道隆臣、郭　伸
- Organizer
  第36回日本神経科学大会Neuro2013
- Place of Presentation
  京都、日本
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] AMPA受容体サブユニットGluA2のQ/R 部位RNA編集率に対する薬剤の効果2013
- Author(s)
  澤田準、相澤仁志、淺野目明日香、高橋佳恵、斉藤司、片山隆行、長谷部直幸、山下雄也、郭　伸
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京、日本
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] 筋萎縮性側索硬化症関連タンパク質：TDP-43封入体の形成ーマウス胎仔電気穿孔法による大脳皮質運動野への疾患関連遺伝子の導入2013
- Author(s)
  10. 赤松恵、詫間浩、山下雄也、岡田拓也、石井一弘、桝和子、郭伸、桝正幸、玉岡晃
- Organizer
  第36回日本神経科学大会Neuro2013
- Place of Presentation
  京都、日本
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] Calpain-dependent cleavage of TDP-43 plays a crucial role in ALS pathology2013
- Author(s)
  Yamashita T, Hideyama T, Teramoto S, Takano J, Iwata N, Saido TC, Kwak S
- Organizer
  8th Brain Research conference “RNA binding proteins in neurological disease”
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] 「RNA editing and ALS」2012
- Author(s)
  Kwak S, Hideyama T, Yamashita T
- Organizer
  6th International symposium on nanomedicine
- Place of Presentation
  Shimane, Matsue
- Year and Date
  2012-11-29
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] RNA editing and ALS2012
- Author(s)
  Kwak S., Hideyama T., Yamashita T.
- Organizer
  6th International symposium on nanomedicine.
- Place of Presentation
  Shimane, Matsue, kunibikimesse
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] Downregulation of RNA editing enzyme ADAR2 and sporadic ALS2011
- Author(s)
  Hideyama, T., Yamashita, T., Aizawa, H. and Kwak, S
- Organizer
  The 22nd International Symposium on MND/ALS
- Place of Presentation
  Sydney, Australia.
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] Abnormal GluR2 RNA editing and TDP-43 pathology in ALS motor neurons.2011
- Author(s)
  Yamashita, T., Hideyama, T., Hachiga, K., Teramoto, S. and Kwak, S.
- Organizer
  41st Annual Meeting Society for Neuroscience
- Place of Presentation
  Washington DC, USA.
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] Abnormal GluR2 RNA editing and TDP-43 pathology in ALS motor neurons.2011
- Author(s)
  Yamashita, T., Hideyama, T., Hachiga, K., Teramoto, S. and Kwak, S.
- Organizer
  6th Brain Research conference "RNA binding proteins in neurological disease
- Place of Presentation
  Washington DC, USA.
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] ALS 運動ニューロンにおけるRNA編集異常とTDP-43 の病理. Abnormal GluR2 RNA editing and TDP-43 pathology in ALS motor neurons2011
- Author(s)
  山下雄也、日出山拓人、八賀康祐、寺本さやか、郭伸
- Organizer
  第34回神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] AMPA受容体サブユニットGluR2のQ/R部位RNA編集率に及ぼす各種薬剤の効果2011
- Author(s)
  澤田潤、相澤仁志、片山隆行、長谷部直幸、山下雄也、郭伸
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] AMPA 受容体サブユニットGluR2 のQ/R 部位RNA 編集率に及ぼす各種薬剤の効果.2011
- Author(s)
  澤田潤、相澤仁志、片山隆行、長谷部直幸、山下雄也、郭伸.
- Organizer
  第52 回日本神経学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] 孤発性ALSにおけるRNA編集異常のメカニズムと運動ニューロン死2011
- Author(s)
  日出山拓人、山下雄也、相澤仁志、柿田明美、高橋均、辻省次、鈴木岳史、SeeburgPH,HiguchiM,高橋良輔、三澤日出巳、郭伸
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] Inefficient RNA editing of GluA2 with ADAR2 downregulation and sporadic ALS2011
- Author(s)
  Hideyama, T., Yamashita, T., Aizawa, H. and Kwak, S
- Organizer
  8th IBRO World Congress of Neuroscience
- Place of Presentation
  Firenze, Itary
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] Inefficient RNA editing of GluA2 with ADAR2 downregulation and sporadic ALS.2011
- Author(s)
  Hideyama, T., Yamashita, T., Aizawa, H. and Kwak, S.
- Organizer
  8th IBRO World Congress of Neuroscience
- Place of Presentation
  Firenze, Itary.
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] 孤発性ALS におけるRNA 編集異常のメカニズムと運動ニューロン死.2011
- Author(s)
  日出山拓人、山下雄也、相澤仁志、柿田明美、高橋均、辻省次、鈴木岳史、Seeburg PH, Higuchi M, 高橋良輔、三澤日出巳、郭伸.
- Organizer
  第5２回日本神経学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] Abnormal GluR2 RNA editing and TDP-43 pathology in ALS motor neurons2011
- Author(s)
  Yamashita, T., Hideyama, T., Hachiga, K., Teramoto, S. and Kwak, S
- Organizer
  6th Brain Research conference "RNA binding proteins in neurological disease
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] ADAR2 賦活物質のin vitro スクリーニングシステムの開発：孤発性ALS 治療薬の探索.2011
- Author(s)
  山下雄也、寺本さやか、日出山拓人、郭伸.
- Organizer
  包括型脳科学研究推進支援ネットワーク夏のワークショップ
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] Abnormal GluR2 RNA editing and TDP-43 pathology in ALS motor neurons2011
- Author(s)
  Yamashita, T., Hideyama, T., Hachiga, K., Teramoto, S. and Kwak, S
- Organizer
  41st Annual Meeting Society for Neuroscience
- Place of Presentation
  Washington DC, USA.
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] Downregulation of RNA editing enzyme ADAR2 and sporadic ALS.2011
- Author(s)
  Hideyama, T., Yamashita, T., Aizawa, H. and Kwak, S.
- Organizer
  The 22nd International Symposium on MND/ALS
- Place of Presentation
  Sydney, Australia.
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] ALS 運動ニューロンにおけるRNA編集異常とTDP-43 の病理. Abnormal GluR2 RNA editing and TDP-43 pathology in ALS motor neurons.2011
- Author(s)
  山下雄也、日出山拓人、八賀康祐、寺本さやか、郭伸.
- Organizer
  第34 回神経科学大会
- Place of Presentation
  横浜.
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] ADAR2賦活物質のinvitroスクリーニングシステムの開発:孤発性ALS2011
- Author(s)
  山下雄也、寺本さやか、日出山拓人、郭伸
- Organizer
  治療薬の探索.包括型脳科学研究推進支援ネットワーク夏のワークショップ
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790977
[Presentation] Sporadic ALS model mice by RNA editing enzyme abnormality.2008
- Author(s)
  Hideyama T, Yamashita T, Tsuji S, Takahashi R, Misawa H, Suzuki T, Kwak S
- Organizer
  6th Forum of European Neuroscience Forum 2008
- Place of Presentation
  Geneve
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] RNA編集異常による孤発性ALSモデルマウスの開発2008
- Author(s)
  日出山拓人, 西本祥仁, 山下雄也, 辻省次, 高橋良輔, 三澤日出巳, 鈴木岳之, 郭伸
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Slow death of motor neurons in sporadic ALS mouse model by conditional targeting of RNA editing enzyme ADAR22008
- Author(s)
  Hideyama T, Yamashita T, Tsuji S, Takahashi R, Misawa H, Suzuki T, Kwak S
- Organizer
  The 19th International Symposium on MND/ALS. 2008
- Place of Presentation
  Birmingham
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Slow death of motor neurons in sporadic ALS mouse model by conditi onal targeting of RNA editing enzyme ADAR22008
- Author(s)
  Hideyama T, Yamashita T, Tsuji S, Takahashi R, Misawa H. Suzuki T, Kwak S
- Organizer
  The 19^<th> International Symposium on MND/ALS
- Place of Presentation
  Birmingham, 英国
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Slow neuronal death of motor neurons in sporadic ALS mouse model by RNA editing enzyme ADAR2 knockout2008
- Author(s)
  Hideyama T, Yamashita T, Tsuji S, Takahashi R, Misawa H, Suzuki T, Kwak S
- Organizer
  Society for neuroscience 38th Annual Meeting
- Place of Presentation
  Washington DC, 米国
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Regulation mechanism of GluR2 Q/R site-editing in cultured cell lines2008
- Author(s)
  Yamashita T, Tadami C, Nishimoto Y, Hideyama T, Kimura D, Suzuki T, Kwak S
- Organizer
  Society for neuroscience 38th Annual Meeting
- Place of Presentation
  Washington, DC
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Regulation mechanism of G1uR2 Q/R site-editing in cultured cell lines2008
- Author(s)
  Yamashita T, Tadami C, Nishimoto Y, Hideyama T, Kimura D, Suzuki T, Kwak S
- Organizer
  Society for neuroscience 38th Annual Meeting
- Place of Presentation
  Washington DC, 米国
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] AMPA受容体サブユニットGluR2のQ/R部位RNA編集率に及ぼす各種薬剤の効果2008
- Author(s)
  澤田潤, 相澤仁志, 山下雄也, 油川陽子, 長谷部直幸, 郭伸
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] 培養細胞によるGluR2 Q/R部位の編集制御機構2008
- Author(s)
  山下雄也, 只見智恵子, 西本祥仁, 日出山拓人, 木村大輔, 鈴木岳之, 郭伸
- Organizer
  第31回神経科学大会 Neuro2008
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] RNA編集異常による孤発性筋萎縮性側索硬化症モデルマウスの作製2008
- Author(s)
  郭伸, 日出山拓人, 山下雄也, 辻省次, 高橋良輔, 三澤日出巳, 木村大輔, 鈴木岳之
- Organizer
  第31回神経科学大会、Neuro2008
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] 培養細胞によるGluR2Q/R部位の編集制御機構2008
- Author(s)
  山下雄也, 只見智恵子, 西本祥仁, 日出山拓人, 木村大輔, 鈴木岳之, 郭伸
- Organizer
  第31回神経科学大会、Neuro2008
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Slow neuronal death of motor neurons in sporadic ALS mouse model by RNA editing enzyme ADAR2 knockout.2008
- Author(s)
  Hideyama T, Yamashita T, Tsuji S, Takahashi R, Misawa H, Suzuki T, Kwak S
- Organizer
  38th Annual Meeting Society for Neuroscience
- Place of Presentation
  Washington
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Sporadic ALS model mice by RNA editing enzyme abnormality2008
- Author(s)
  Hideyama T, Yamashita T, Tsuji S, Takahashi R, Misawa H. Suzuki T. Kwak S
- Organizer
  6^<th> Forum of European Neuroscience Forum 2008
- Place of Presentation
  Geneve, スイス国
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Establishment of a novel Hela cell line stably expressing the half-echted GluR2 transcript2007
- Author(s)
  Yamashita T., Tadami C., Nishimoto Y., Kimura D., Suzuki T., Kwak S.
- Organizer
  Society for Neuroscience 37th Annual Meeting
- Place of Presentation
  San Diego, California
- Year and Date
  2007-11-06
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Death of motor neurons in mice deficient in an RNA editing enzyme2007
- Author(s)
  Hideyama, T, Yamashita, T, Tsuji, S, Takahashi, R, Misawa, H, Suzuki, T, Kwak, S
- Organizer
  Amiotroph Later Scl, P153
- Place of Presentation
  Tronto, Canada
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] RNA編集異常による孤発性ALSモデルマウスの開発2007
- Author(s)
  郭伸, 日出山拓人, 西本祥仁, 山下雄也, 辻省次, 高橋良輔, 三澤日出巳, 鈴木岳之
- Organizer
  第30回日本神経科学会合同大会 Neuro2007、P1-h47
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Tet onシステムを利用したRNA編集活性測定株の樹立2007
- Author(s)
  山下雄也, 只見知恵子, 西本祥仁, 木村大輔, 鈴木岳之, 郭伸
- Organizer
  第50回日本神経化学会(横浜)大会合同大会 Neuro2007、P1-j01
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Tet-Onシステムを利用したAMPA受容体サブユニットGluR2のRNA編集率測定株の樹立2007
- Author(s)
  山下雄也、只見智恵子、西本祥仁、木村大輔、鈴木岳之、郭伸
- Organizer
  Neuro2007 第30回日本神経科学大会・第50回日本神経化学会大会、第17回日本神経回路学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-18023012
[Presentation] RNA編集異常による孤発性ALSモデルマウスの開発2007
- Author(s)
  日出山拓人、西本祥仁、山下雄也、辻省次、高橋良輔、三澤日出巳、鈴木岳之、郭伸
- Organizer
  東京大学生命研究ネット
- Place of Presentation
  東京
- Year and Date
  2007-09-15
- Data Source
  KAKENHI-PROJECT-18023012
[Presentation] 孤発性筋萎縮性側索硬化症のRNA編集異常2007
- Author(s)
  日出山拓人、西本祥仁、山下雄也、伊藤杏子、辻省次、高橋良輔、三澤日出巳、鈴木岳之、郭伸
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-16
- Data Source
  KAKENHI-PROJECT-18023012
[Presentation] Tet Onシステムを利用したRNA編集活性測定株の樹立2007
- Author(s)
  山下雄也、只見知恵子、西本祥仁、木村大輔、鈴木岳之、郭伸
- Organizer
  第50回日本神経化学会大会合同大会Neuro2007
- Place of Presentation
  横浜
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Establishment of a novel Hela cell line stably expressing the half-edited GluR2 transcript2007
- Author(s)
  Yamashita T, Tadami C, Nishimoto Y, Kimura D, Suzuki T, Kwak S
- Organizer
  37th Annual Meeting Society for Neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2007-11-03
- Data Source
  KAKENHI-PROJECT-18023012
[Presentation] 孤発性ALSのバイオマーカーの開発2007
- Author(s)
  西本祥仁、日出山拓人、山下雄也、鈴木則宏、郭伸
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] RNA editing and ADAR2 in sporadic ALS2007
- Author(s)
  Hideyama T, Nishimoto Y, Yamashita T, Kakita A, Takahashi H, Tsuji S, Kwak S
- Organizer
  NEURO-COE RETREAT 2007
- Place of Presentation
  Hakone
- Year and Date
  2007-07-13
- Data Source
  KAKENHI-PROJECT-18023012
[Presentation] Establishment of a novel Hela cell line stably expressing the half-edited GluR2 transcript.2007
- Author(s)
  Yamashita, T, Tadami, C, Nishimoto,Y, Kimura, D, Suzuki,T, Kwak, S
- Organizer
  Society for Neuroscience 37th Annual Meeting, No. 591.16.
- Place of Presentation
  San Diego, California
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Alteration of RNA editing and neuronal death in motor neuron diseases.2007
- Author(s)
  Hideyama, T, Nishimoto, Y, Yamashita, T, Tsuji, S, Takahashi, H, Kakita, A, Suzuki, T, Kwak, S
- Organizer
  ENS 2007, No. 700.
- Place of Presentation
  Rhodes
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] RNA編集異常による孤発性ALSモデルマウスの開発と検討2007
- Author(s)
  郭伸、日出山拓人、西本祥仁、山下雄也、辻省次、高橋良輔、三澤日出巳、鈴木岳之
- Organizer
  Neuro2007 第30回日本神経科学大会・第50回日本神経化学会大会、第17回日本神経回路学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-18023012
[Presentation] Tet onシステムを利用したAMPA受容体サブユニットGluR2のRNA編集率測定株の樹立2007
- Author(s)
  山下雄也、只見知恵子、西本祥仁、木村大輔、鈴木岳之、郭伸
- Organizer
  東京大学生命科学研究ネットワークシンポジウム2007
- Place of Presentation
  東京
- Year and Date
  2007-09-15
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] Death of motor neurons in mice deficient in an RNA editing enzyme2007
- Author(s)
  Hideyama T, Yamashita T, Tsuji S, Takahashi R, Misawa H, Suzuki T, Kwak S
- Organizer
  The 18th International Symposium on MND/ALS.
- Place of Presentation
  Toronto
- Year and Date
  2007-11-30
- Data Source
  KAKENHI-PROJECT-18023012
[Presentation] 孤発性ALSのバイオマーカーの開発2007
- Author(s)
  西本祥仁、日出山拓人、山下雄也、鈴木則宏、郭伸
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-16
- Data Source
  KAKENHI-PROJECT-18023012
[Presentation] 孤発性筋萎縮性側索硬化症のRNA編集異常2007
- Author(s)
  日出山拓人, 西本祥仁, 山下雄也, 伊藤杏子, 辻省次, 高橋良輔, 三澤日出巳, 鈴木岳之, 郭伸
- Organizer
  第48回日本神経学会総会、No. 10022
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] グリオーマ細胞におけるAMPA受容体サブユニットGluR2のRNA編集率の検討2007
- Author(s)
  只見智恵子, 木村大輔, 伊藤杏子, 山下雄也, 鈴木岳之, 郭伸
- Organizer
  第80回日本薬理学会年会、No. 10300
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] 孤発性ALSのバイオマーカーの開発2007
- Author(s)
  西本祥仁, 日出山拓人, 山下雄也, 鈴木則宏, 郭伸
- Organizer
  第48回日本神経学会総会、P-10122
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19790601
[Presentation] 子宮内電気穿孔法TDP-43遺伝子導入によるin vivo形成封入体の微細形態の検討
- Author(s)
  詫間　浩, 赤松　恵, 山下雄也, Hartmut Oehring, 岡田拓也, 枡　和子, 石井一弘, Gustav Jirikowsk, 郭　伸, 枡　正幸, 玉岡　晃
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場, 福岡,　日本
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] Gene therapy for sporadic ALS using an intravenous injection of AAV vector.
- Author(s)
  Yamashita T, Chai HL, Teramoto S, Muramatsu S, Kwak S
- Organizer
  The 25th International Symposium on MND/ALS
- Place of Presentation
  Brussels, Belgium
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] TDP-43病理形成メカニズムにおけるTDP-43のカルパイン依存性断片化の意義
- Author(s)
  山下雄也, 郭　伸
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場, 福岡,　日本
- Year and Date
  2014-05-21 – 2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] ペランパネルはALSモデルマウス運動ニューロンのTDP-43病理を軽減する
- Author(s)
  蔡　慧玲, 郭　伸, 山下雄也
- Organizer
  第37回日本神経科学大会Neuro2014
- Place of Presentation
  パシフィコ横浜, 横浜、日本
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] Development of a gene therapy for sporadic ALS by normalizing ADAR2 activity in the motor neurons using a vascular type AAV vector.
- Author(s)
  Kwak S, Yamashita T, Chai HL, Teramoto S, Muramatsu S-I
- Organizer
  The 24th Meeting of the European Neurological Society
- Place of Presentation
  Istanbul, Turkey
- Year and Date
  2014-05-31 – 2014-06-03
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] AMPA受容体サブユニットGluA2のQ/R部位RNA編集率に対する薬剤の効果
- Author(s)
  澤田　潤, 相澤仁志, 浅野目明日香, 高橋佳恵, 斎藤　司, 片山隆行, 山下雄也, 郭　伸, 長谷部直幸
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場, 福岡,　日本
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] ALSモデルマウスを用いたALSの遺伝子治療法開発の試み.
- Author(s)
  山下雄也, 蔡　慧玲, 寺本さやか, 辻　省次, 島崎久仁子, 村松慎一, 郭　伸
- Organizer
  第37回日本神経科学大会Neuro2014
- Place of Presentation
  パシフィコ横浜, 横浜、日本
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] Mechanism-based gene therapy for ALS using sporadic ALS model mice
- Author(s)
  Yamashita T, Chai HL, Teramoto S, Tsuji S, Shimazaki K, Muramatsu S-I, Kwak S
- Organizer
  The 45th Annual Meeting Society for Neuroscience
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] Electron microscopic observation of intranuclear aggregation of TDP-43 in mouse cerebral cortex produced by in utero electroporation
- Author(s)
  Akamatsu M, Takuma H, Yamashita T, Okada T, Masu-Keino K, Oehring H, Kwak S, Masu M, Jirikowski FG
- Organizer
  第37回日本神経科学大会Neuro2014
- Place of Presentation
  パシフィコ横浜, 横浜、日本
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] 分子病態に基づいた孤発性ALSの遺伝子治療法の開発
- Author(s)
  郭　伸, 山下雄也, 蔡　慧玲, 寺本さやか, 辻省次, 島崎久仁子, 村松愼一
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場, 福岡,　日本
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461269
[Presentation] 筋炎と悪性腫瘍との関連に関する疫学的検討
- Author(s)
  肥田あゆみ, 井上真奈美, 前田明子, 山下雄也, 郭　伸、辻　省次, 清水　潤
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場, 福岡,　日本
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461269
[]

1. KWAK Shin (40160981)

# of Collaborated Projects: 2 results

# of Collaborated Products: 50 results
2. MURAMATSU S Hinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 佐々木彰一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 桝和子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 桝正幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMASHITA Takenari 山下 雄也

Research Projects

Research Products

Co-Researchers

Ca2+流入異常を介した核-細胞質システム破綻による細胞死メカニズムの解析Principal Investigator

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Analysis of the molecular link of amyotrophic lateral sclerosis associated genes in sporadic ALS model micePrincipal Investigator

Principal Investigator

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Analysis of cascade of neuronal cell death for TDP-43 in sporadic amyotrophic lateral sclerosisPrincipal Investigator

Principal Investigator

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Search for microRNA capable of modifying with ADAR2 activityPrincipal Investigator

Principal Investigator

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ALS運動ニューロンにおけるGLUR2RNA編集異常の解析

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Research Institution

[Book] 遺伝子医学MOOK 30号2016

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Data Source

[Book] AMPA receptor-mediated neuronal death in motor neuron diseases. In: Amino Acid Receptor Research, Eds. Paley BF, Warfield TE2008

Author(s)

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[Book] In Amino Acid Receptor Research (AMPA receptor-mediated neuronal death in motor neuron diseases)2008

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[Book] グルタミン酸受容体と神経細胞死、神経変性疾患のサイエンス2007

Author(s)

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Data Source

[Book] 神経変性疾患のサイエンス(グルタミン酸受容体と神経細胞死)2007

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[Book] 神経変性疾患のサイエンス(神経細胞死とグルタミン酸受容体)2007

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[Journal Article] Extracellular RNAs as Biomarkers of Sporadic Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases.2019

Author(s)

Journal Title

DOI

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[Journal Article] Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein.2019

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[Journal Article] ADAR2-dependent A-to-I RNA editing in the extracellular linear and circular RNAs.2018

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[Journal Article] Cell death cascade and molecular therapy in ADAR2-deficient motor neurons of ALS.2018

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Journal Title

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Data Source

[Journal Article] Altered intracellular milieu of ADAR2-deficient motor neurons in amyotrophic lateral sclerosis2017

Author(s)

YAMASHITA Takenari 山下雄也

[Journal Article] 特集認知症･神経変性疾患の克服への挑戦 Ⅲ.新たな技術開発によるチャレンジ ALSの遺伝子治療─分子病態解明から治療へ2016