Noguchi Takuya 野口拓也

… Alternative Names

NOGUCHI Takuya 野口拓也

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Researcher Number	20431893
Other IDs	https://orcid.org/0000-0001-6187-6645
Affiliation (Current)	2025: 岩手医科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 東北大学, 薬学研究科, 准教授 2014 – 2015: 東北大学, 薬学研究科(研究院), 准教授 2013: 群馬大学, 生体調節研究所, 助教 2007 – 2008: The University of Tokyo, 大学院・薬学系研究科, 助教 2006: 東京大学, 大学院薬学系研究科, 助手
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / General medical chemistry / Functional basic dentistry Except Principal Investigator Functional basic dentistry / Biological Sciences / Basic Section 57040:Regenerative dentistry and dental engineering-related / Dental engineering/Regenerative dentistry / Biological pharmacy
Keywords	Principal Investigator Fas / 自然免疫応答 / リソソームストレス / 転移抑制剤 / 遠隔転移 / 液滴 / p62/SQSTM1 / MAP キナーゼ / Toll-like receptor4 / Toll-like receptor … More / 炎症誘導 / ユビキチン化酵素 / MAPキナーゼ / FAS / TNF受容体 / プロテインキナーゼ / RNAiスクリーニング / カスパーゼ / Fasリガンド / シグナル伝達 / キナーゼ / STK11 / アポトーシス / kinase / Caspase-8 / TNF / FasL / Kinase / Apoptosis / 細胞死 / 活性酸素 / リン酸化酵素 / 細胞内シグナル伝達 … More Except Principal Investigator ストレス / 神経細胞分化 / PC12細胞 / アポトーシス / MAPキナーゼ / 周波数制御式反復微細振動刺激 / MAPK / MC3T3-E1 / PC12 / 微細振動刺激 / 骨芽細胞分化 / 歯科医用工学 / 神経分化誘導 / 再生医歯学 / SH-SY5Y細胞 / N2A細胞 / 神経成長因子 / 骨形成タンパク質 / サブクローニング / 温熱刺激 / 線虫 / p38 / PGAM5 / 浸透圧 / ASKファミリー / 細胞・組織 / タンパク質分解 / 蛋白質 / ストレス応答 / 小胞外ストレス / 炎症 / 発癌 / 口腔生化学 / ASK1 / ALS / 神経細胞死 / Derlin-l / ASEl / 小胞体ストレス / 筋萎縮性側索硬化症 Less

革新的転移抑制剤創出を見据えたp62/SQSTM液滴の病理的役割の解明Principal Investigator
- Principal Investigator
  
  野口拓也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tohoku University
Elucidation of the physiological and pathological roles of LINCR in innate immune response with a view to creating drugs to treat sepsisPrincipal Investigator
- Principal Investigator
  
  Noguchi Takuya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tohoku University
周波数制御式反復微細振動(FRMV)による神経細胞分化誘導とその分子的機序の検討
- Principal Investigator
  
  工藤忠明
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Tohoku University
Elucidation of balancing mechanisms of death receptor signaling mediated by STK11Principal Investigator
- Principal Investigator
  
  Noguchi Takuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tohoku University
Development of efficient and versatile method for inducing neuronal differentiation with temperature-controlled repeated thermal stimulation (TRTS)
- Principal Investigator
  
  Kudo Tada-aki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  Tohoku University
Elucidation of the phospho-dependent mechanisms of apoptosis inductionPrincipal Investigator
- Principal Investigator
  
  Noguchi Takuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
  Gunma University
小胞体品質管理におけるタンパク質分解の新規分子メカニズムの解明
- Principal Investigator
  
  西頭英起
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Drug development by the molecular mechanism-based analysis of stress signaling
- Principal Investigator
  
  ICHIJO Hidenori
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
口腔疾患に関わるストレスシグナル解明への遺伝学的アプローチ
- Principal Investigator
  
  一條秀憲
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokyo
Functional analysis of ASK2, a novel stress-responsive kinase, in carcinogenesis of oral squamous cell carcinomas
- Principal Investigator
  
  TAKEDA Kohsuke
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokyo
異常蛋白質蓄積によるASK1シグナルを介した神経変性細胞死の分子病態の解明
- Principal Investigator
  
  NISHITOH Hideki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
活性酸素種によるASK1活性化制御機構の解明Principal Investigator
- Principal Investigator
  
  野口拓也
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokyo

[Journal Article] The E3 Ubiquitin Protein Ligase LINCR Amplifies the TLR-Mediated Signals through Direct Degradation of MKP12024
- Author(s)
  Yokosawa Takumi、Miyagawa Sayoko、Suzuki Wakana、Nada Yuki、Hirata Yusuke、Noguchi Takuya、Matsuzawa Atsushi
- Journal Title
  
  Cells
  
  Volume: 13 Issue: 8 Pages: 687-687
- DOI
  10.3390/cells13080687
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02691
[Journal Article] Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos2024
- Author(s)
  Hamano Shuhei、Noguchi Takuya、Asai Yukino、Ito Ryo、Komatsu Ryuto、Sato Tetsu、Inoue Aya、Maruyama Tomoe、Kudo Tada-aki、Hirata Yusuke、Shindo Sawako、Uchida Yasuo、Hwang Gi-Wook、Matsuzawa Atsushi
- Journal Title
  
  Cell Death Discovery
  
  Volume: 10 Issue: 1 Pages: 74-74
- DOI
  10.1038/s41420-024-01838-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ0165, KAKENHI-PROJECT-21K09929, KAKENHI-PROJECT-23K06111, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691
[Journal Article] The NLRP3 Inflammasome Is a Major Cause of Acute Renal Failure Induced by Polypeptide Antibiotics2024
- Author(s)
  Kagi Tomohiro、Inoue Aya、Noguchi Takuya、Suzuki Wakana、Takano Saya、Otani Kohei、Naganuma Rio、Sekiguchi Yuto、Hirata Yusuke、Shindo Sawako、Hwang Gi-Wook、Matsuzawa Atsushi
- Journal Title
  
  The Journal of Immunology
  
  Volume: - Issue: 11 Pages: 1807-1818
- DOI
  10.4049/jimmunol.2300193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22KJ0288, KAKENHI-PROJECT-21H02691
[Journal Article] Physical Stimulation Methods Developed for In Vitro Neuronal Differentiation Studies of PC12 Cells: A Comprehensive Review2024
- Author(s)
  Tominami Kanako、Kudo Tada-aki、Noguchi Takuya、Hayashi Yohei、Luo You-Ran、Tanaka Takakuni、Matsushita Ayumu、Izumi Satoshi、Sato Hajime、Gengyo-Ando Keiko、Matsuzawa Atsushi、Hong Guang、Nakai Junichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 2 Pages: 772-772
- DOI
  10.3390/ijms25020772
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09929, KAKENHI-PROJECT-22K06245, KAKENHI-PROJECT-23K09127, KAKENHI-PROJECT-21K19693, KAKENHI-PUBLICLY-22H04662, KAKENHI-PROJECT-20H03850, KAKENHI-PLANNED-21H05298
[Journal Article] Reactive sulfur species disaggregate the SQSTM1/p62-based aggresome-like induced structures via the HSP70 induction and prevent parthanatos2023
- Author(s)
  Yamada Yutaro、Noguchi Takuya、Suzuki Midori、Yamada Mayuka、Hirata Yusuke、Matsuzawa Atsushi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: in press Issue: 6 Pages: 104710-104710
- DOI
  10.1016/j.jbc.2023.104710
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-20J20688, KAKENHI-PROJECT-21J10638, KAKENHI-PROJECT-23K06111, KAKENHI-PROJECT-21H02620
[Journal Article] LLPS of SQSTM1/p62 and NBR1 as outcomes of lysosomal stress response limits cancer cell metastasis2023
- Author(s)
  Noguchi Takuya、Sekiguchi Yuto、Shimada Tatsuya、Suzuki Wakana、Yokosawa Takumi、Itoh Tamaki、Yamada Mayuka、Suzuki Midori、Kurokawa Reon、Hirata Yusuke、Matsuzawa Atsushi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 43 Pages: 44-44
- DOI
  10.1073/pnas.2311282120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06111, KAKENHI-PROJECT-23KJ0096, KAKENHI-WRAPUP-23H05424, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691
[Journal Article] The NLRP3 Inflammasome Works as a Sensor for Detecting Hypoactivity of the Mitochondrial Src Family Kinases2023
- Author(s)
  Sekiguchi Y, Takano S, Noguchi T, Kagi T, Komatsu R, Tan M, Hirata Y, Matsuzawa A
- Journal Title
  
  J Immunol
  
  Volume: 210 Issue: 6 Pages: 795-806
- DOI
  10.4049/jimmunol.2200611
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-21J10592, KAKENHI-PROJECT-22KJ0288, KAKENHI-PROJECT-21K19325, KAKENHI-PROJECT-20KK0361, KAKENHI-PUBLICLY-21H00268
[Journal Article] SP600125 Enhances Temperature-Controlled Repeated Thermal Stimulation-Induced Neurite Outgrowth in PC12-P1F1 Cells2022
- Author(s)
  Luo You-Ran、Kudo Tada-aki、Tominami Kanako、Izumi Satoshi、Tanaka Takakuni、Hayashi Yohei、Noguchi Takuya、Matsuzawa Atsushi、Nakai Junichi、Hong Guang、Wang Hang
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 24 Pages: 15602-15602
- DOI
  10.3390/ijms232415602
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09929, KAKENHI-PROJECT-22K06245, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-19K06434, KAKENHI-PROJECT-21K19325, KAKENHI-PUBLICLY-21H00268, KAKENHI-PUBLICLY-20H04917
[Journal Article] The polypeptide antibiotic polymyxin B acts as a pro-inflammatory irritant by preferentially targeting macrophages2022
- Author(s)
  Kagi T, Naganuma R, Inoue A, Noguchi T, Hamano S, Sekiguchi Y, Hwang GW, Hirata Y, Matsuzawa A
- Journal Title
  
  J Antibiot
  
  Volume: 75 Issue: 1 Pages: 29-39
- DOI
  10.1038/s41429-021-00490-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H00268, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-21J10592, KAKENHI-PROJECT-20KK0361, KAKENHI-PROJECT-21K19325, KAKENHI-PROJECT-20K07011
[Journal Article] The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin2022
- Author(s)
  Shimada Tatsuya、Yabuki Yohsuke、Noguchi Takuya、Tsuchida Mei、Komatsu Ryuto、Hamano Shuhei、Yamada Mayuka、Ezaki Yusuke、Hirata Yusuke、Matsuzawa Atsushi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 17 Pages: 10064-10064
- DOI
  10.3390/ijms231710064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-21J10638, KAKENHI-PROJECT-20K07011, KAKENHI-PROJECT-20KK0361
[Journal Article] Mechanisms of gefitinib-induced interstitial pneumonitis: why and how the TKI perturbs innate immune systems?2021
- Author(s)
  Kagi T, Noguchi T, Matsuzawa A
- Journal Title
  
  Oncotarget
  
  Volume: 12 Issue: 13 Pages: 1321-1322
- DOI
  10.18632/oncotarget.27958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H00268, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-21K19325
[Journal Article] Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia2021
- Author(s)
  Toyama Takashi、Hoshi Takayuki、Noguchi Takuya、Saito Yoshiro、Matsuzawa Atsushi、Naganuma Akira、Hwang Gi-Wook
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 9831-9831
- DOI
  10.1038/s41598-021-89210-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05491, KAKENHI-PUBLICLY-21H00268, KAKENHI-PROJECT-19H04276, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-21K19325, KAKENHI-PROJECT-21K19321, KAKENHI-PROJECT-20H00488
[Journal Article] The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK12021
- Author(s)
  Shimada T, Kudoh Y, Noguchi T, Kagi T, Suzuki M, Tsuchida M, Komatsu H, Takahashi M, Hirata Y, Matsuzawa A
- Journal Title
  
  Int J Mol Sci
  
  Volume: 22 Issue: 11 Pages: 5796-5796
- DOI
  10.3390/ijms22115796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H00268, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-20J20688, KAKENHI-PROJECT-20K07011, KAKENHI-PROJECT-20KK0361, KAKENHI-PROJECT-21K19325
[Journal Article] trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway2021
- Author(s)
  Hirata Y, Takahashi M, Yamada Y, Matsui R, Inoue A, Ashida R, Noguchi T, Matsuzawa A
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 10350-10350
- DOI
  10.1038/s41598-021-89506-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H00268, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-20K07011, KAKENHI-PROJECT-20KK0361, KAKENHI-PROJECT-21K19325
[Journal Article] Gefitinib initiates sterile inflammation by pomoting IL-1β and HMGB1 release via two distinct mechanisms2021
- Author(s)
  Takuya Noguchi, Yuto Sekiguchi, Yuki Kudoh, Rio Naganuma, Tomohiro Kagi, Akiko Nishidate, Kazuhiro Maeda, Chizuru Ishii, Takashi Toyama, Yusuke Hirata, Gi-Wook Hwang, Atsushi Matsuzawa
- Journal Title
  
  Cell Death. Dis.
  
  Volume: 12 Issue: 1 Pages: 49-49
- DOI
  10.1038/s41419-020-03335-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07011, KAKENHI-PUBLICLY-19H05282, KAKENHI-PUBLICLY-20H05493, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-18K06622, KAKENHI-PROJECT-19K22481, KAKENHI-PROJECT-19K16345
[Journal Article] The Antibiotic Cefotaxime Works as Both an Activator of Nrf2 and an Inducer of HSP70 in Mammalian Cells2020
- Author(s)
  Yamada Mayuka、Suzuki Midori、Noguchi Takuya、Yokosawa Takumi、Sekiguchi Yuto、Mutoh Natsumi、Toyama Takashi、Hirata Yusuke、Hwang Gi-Wook、Matsuzawa Atsushi
- Journal Title
  
  BPB Reports
  
  Volume: 3 Issue: 1 Pages: 16-21
- DOI
  10.1248/bpbreports.3.1_16
- NAID
  130007944896
- ISSN
  2434-432X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06622
[Journal Article] Pro-apoptotic functions of TRAF2 in p53-mediated apoptosis induced by cisplatin2020
- Author(s)
  Tsuchida, M., Yokozawa, T., Noguchi, T., Shimada, T., Yamada, M., Sekiguchi, Y., Hirata, Y., Matsuzawa, A.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 4 Pages: 219-226
- DOI
  10.2131/jts.45.219
- NAID
  130007825449
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22481, KAKENHI-PUBLICLY-19H05282, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-18J20440, KAKENHI-PROJECT-18K06622
[Journal Article] TAK1 Mediates ROS Generation Triggered by the Specific Cephalosporins through Noncanonical Mechanisms.2020
- Author(s)
  Midori Suzuki, Yukino Asai, Tomohiro Kagi, Takuya Noguchi, Mayuka Yamada, Yusuke Hirata, Atsushi Matsuzawa
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 24 Pages: 9497-9497
- DOI
  10.3390/ijms21249497
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07011, KAKENHI-PUBLICLY-19H05282, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-20J20688, KAKENHI-PROJECT-18K06622
[Journal Article] trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop2020
- Author(s)
  Yusuke Hirata, Aya Inoue, Saki Suzuki, Miki Takahashi, Ryosuke Matsui, Nozomu Kono, Takuya Noguchi, Atsushi Matsuzawa
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-16
- DOI
  10.1038/s41598-020-59636-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06622, KAKENHI-PROJECT-19K22481, KAKENHI-PUBLICLY-19H05282, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-17H05053, KAKENHI-PROJECT-18J10828, KAKENHI-PROJECT-18K14894
[Journal Article] Pro-caspase-3 protects cells from polymyxin B-induced cytotoxicity by preventing ROS accumulation2020
- Author(s)
  T Yokosawa, M Yamada, T Noguchi, S Suzuki, Y Hirata, A Matsuzawa
- Journal Title
  
  The Journal of antibiotics
  
  Volume: 72 Issue: 11 Pages: 848-852
- DOI
  10.1038/s41429-019-0216-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06622, KAKENHI-PUBLICLY-19H05282, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-18K14894
[Journal Article] The Antibiotic Cefotaxime Works as Both an Activator of Nrf2 and an Inducer of HSP70 in Mammalian Cells2020
- Author(s)
  Mayuka Yamada, Midori Suzuki, Takuya Noguchi, Takumi Yokosawa, Yuto Sekiguchi, Natsumi Mutoh, Takashi Toyama, Yusuke Hirata, Gi-Wook Hwang, Atsushi Matsuzawa
- Journal Title
  
  BPB reports
  
  Volume: 3 Pages: 16-21
- NAID
  130007944896
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06622
[Journal Article] The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells2019
- Author(s)
  Yuto Sekiguchi, Mayuka Yamada, Takuya Noguchi, Chise Noomote, Mei Tsuchida, Yuki Kudoh, Yusuke Hirata, Atsushi Matsuzawa
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 44 Issue: 6 Pages: 435-440
- DOI
  10.2131/jts.44.435
- NAID
  130007659535
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06622, KAKENHI-PUBLICLY-19H05282, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-18J11303, KAKENHI-PROJECT-18J20440, KAKENHI-PROJECT-18K14894
[Journal Article] Nuclear-accumulated SQSTM1/p62-based ALIS act as microdomains sensing cellular stresses and triggering oxidative stress-induced parthanatos2018
- Author(s)
  Noguchi Takuya、Suzuki Midori、Mutoh Natsumi、Hirata Yusuke、Tsuchida Mei、Miyagawa Sayoko、Hwang Gi-Wook、Aoki Junken、Matsuzawa Atsushi
- Journal Title
  
  Cell Death & Disease
  
  Volume: 9 Issue: 12 Pages: 1193-1193
- DOI
  10.1038/s41419-018-1245-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06622, KAKENHI-PROJECT-18K14894, KAKENHI-PUBLICLY-17H05494, KAKENHI-PUBLICLY-17H05518, KAKENHI-PROJECT-18H02567
[Journal Article] Role of Apoptosis Signal-regulating Kinase 1 (ASK1) as an activator of the GAPDH-Siah1 Stress-Signaling Cascade.2015
- Author(s)
  Tristan, C.A., Ramos, A., Shahani, N., Emiliani, F.E., Nakajima, H., Noeh, C.C., Kato, Y., Takeuchi, T., Noguchi, T., Kadowaki, H., Sedlak, T.W., Ishizuka, K., Ichijo, H. and Sawa, A.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 290 Pages: 56-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460355
[Journal Article] Depletion of apoptosis signal-regulating kinase 1 prevents bile duct ligation-induced necroinflammation and subsequent peribiliary fibrosis.2014
- Author(s)
  Noguchi, H., Yamada, S., Nabeshima, A., Guo, X., Tanimoto, A., Wang, K.Y., Kitada, S., Tasaki, T., Takama, T., Shimajiri, S., Horlad, H., Komohara, Y., Izumi, H., Kohno, K., Ichijo, H. and Sasaguri, Y.
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 184 Issue: 3 Pages: 644-661
- DOI
  10.1016/j.ajpath.2013.11.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229004, KAKENHI-PROJECT-25650061
[Journal Article] Apoptosis Signal-regulating Kinase 1 deficiency attenuates vascular injury-induced neointimal hyperplasia by suppressing apoptosis in smooth muscle cells.2013
- Author(s)
  Tasaki, T., *Yamada, S., Guo, X., Tanimoto, A., Wang, K-T., Nabeshima, A., Kitada, S., Noguchi H., Kimura, S., Shimajiri, S., Kohno, K., Ichijo, H. and Sasaguri, Y.
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 182 Issue: 2 Pages: 597-609
- DOI
  10.1016/j.ajpath.2012.10.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229004, KAKENHI-PROJECT-23659033
[Journal Article] ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney.2012
- Author(s)
  Naguro I., et al.
- Journal Title
  
  Nature Communications
  
  Volume: 3 Issue: 1 Pages: 1285-1285
- DOI
  10.1038/ncomms2283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J09620, KAKENHI-PROJECT-11J09074, KAKENHI-PROJECT-20229004, KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22390347, KAKENHI-PROJECT-23390058, KAKENHI-PROJECT-23659033, KAKENHI-PROJECT-23659439, KAKENHI-PROJECT-23790078, KAKENHI-PROJECT-24390418, KAKENHI-PROJECT-24659027, KAKENHI-PUBLICLY-23110504, KAKENHI-PUBLICLY-23117510
[Journal Article] p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors2011
- Author(s)
  Sekine,Y., Takagahara,S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K., and Ichijo, H.
- Journal Title
  
  J. Cell Sci.
  
  Volume: 124 Issue: 17 Pages: 3006-3016
- DOI
  10.1242/jcs.085902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229004, KAKENHI-PROJECT-22390347, KAKENHI-PROJECT-22890031, KAKENHI-PUBLICLY-23117510, KAKENHI-PROJECT-23659033, KAKENHI-PROJECT-23700367, KAKENHI-PROJECT-23790078
[Journal Article] Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.2009
- Author(s)
  Takeda, K., Komuro, Y., Hayakawa, T., Oguchi, H., Ishida, Y., Murakami, S., Noguchi, T., Kinoshita, H., Sekine, Y., Iemura, S., Natsume, T., Ichijo H.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 106
  
  Pages: 12301-12305
- Data Source
  KAKENHI-PROJECT-20229004
[Journal Article] Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/ threonine phosphatase to activate ASK12009
- Author(s)
  Takeda, K., Komuro, Y., Hayakawa, T., Oguchi, H., Ishida, Y., Murakami, S., Noguchi, T., Kinoshita, H., Sekine, Y., Iemura, S., Natsume, T., and Ichijo H.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA.
  
  Volume: 106 Issue: 30 Pages: 12301-12305
- DOI
  10.1073/pnas.0901823106
- Data Source
  KAKENHI-PROJECT-20229004
[Journal Article] Ubiquitin-like sequence in ASKI plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.2009
- Author(s)
  Nagai, H., Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A., Ichijo H.
- Journal Title
  
  Mol. Cell 36
  
  Pages: 805-818
- Data Source
  KAKENHI-PROJECT-20229004
[Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.2009
- Author(s)
  Iriyama, T., Takeda, K., Nakamura, H., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., Saegusa, K., Tobiume, K., Homma, T., Shimada, Y., Tsuda, H., Aiko, S., Imoto, I., Inazawa, J., Chida, K., Kamei, Y., Kozuma, S., Taketani, Y., Matsuzawa, A. and Ichijo, H.
- Journal Title
  
  EMBO J. 28
  
  Pages: 843-853
- Data Source
  KAKENHI-PROJECT-19390470
[Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis2009
- Author(s)
  Iriyama, T., Takeda, K., Nakamura, H., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., Saegusa, K., Tobiume, K., Homma, T., Shimada, Y., Tsuda, H., Aiko, S., Imoto, I., Inazawa, J., Chida, K., Kamei, Y., Kozuma, S., Taketani, Y., Matsuzawa, A. and Ichijo H.
- Journal Title
  
  EMBO J.
  
  Volume: 28 Issue: 7 Pages: 843-853
- DOI
  10.1038/emboj.2009.32
- Data Source
  KAKENHI-PROJECT-20229004
[Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.2009
- Author(s)
  Iriyama, T., Takeda, K., Nakamura, H., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., Saegusa, K., Tobiume, K., Homma, T., Shimada, Y., Tsuda, H., Aiko, S., Imoto, I., Inazawa, J., Chida, K., Kamei, Y., Kozuma, S., Taketani, Y., Matsuzawa, A., Ichijo, H.
- Journal Title
  
  EMBO J. 28
  
  Pages: 843-853
- Data Source
  KAKENHI-PROJECT-20229004
[Journal Article] Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death2009
- Author(s)
  Nagai, H,, Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A. and Ichijo H.
- Journal Title
  
  Mol. Cell
  
  Volume: 36 Issue: 5 Pages: 805-818
- DOI
  10.1016/j.molcel.2009.10.016
- Data Source
  KAKENHI-PROJECT-20229004
[Journal Article] Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced aotosis in macrohage2008
- Author(s)
  Noguchi, T., et. al.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 7657-7665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390470
[Journal Article] Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracellular ATP-induced apoptosis in macrophage.2008
- Author(s)
  Noguchi, T., Ishii, K., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K. and Ichijo, H.
- Journal Title
  
  J.Biol.Chem 283
  
  Pages: 7657-7665
- Data Source
  KAKENHI-PROJECT-19390470
[Journal Article] Apoptosis signal-regulating kinase 1 in stress and immune response.2008
- Author(s)
  Takeda, K., Noguchi, T., Naguro, I.. and Ichijo, H.
- Journal Title
  
  Annu. Rev. Pharmacol. Toxicol. (review article) 48
  
  Pages: 199-225
- Data Source
  KAKENHI-PROJECT-19390470
[Journal Article] Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP induced apoptosis in imacrophage.2008
- Author(s)
  Noguchi, T. et al.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 7657-7665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390470
[Journal Article] ALS-linked mutant SOD1 induces ER stress-and ASK1-dependent motor neuron death by targeting Derlin-12008
- Author(s)
  Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K. and Ichijo H.
- Journal Title
  
  Genes Dev.
  
  Volume: 22 Issue: 11 Pages: 1451-1464
- DOI
  10.1101/gad.1640108
- Data Source
  KAKENHI-PROJECT-20229004
[Journal Article] Requirement of reactive oxygen specis-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage.2008
- Author(s)
  Noguchi, T. et. al.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 7657-7665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229004
[Journal Article] Apoptosis Signal-regulating Kinase 1(ASK1)in stress and immune response.2008
- Author(s)
  Takeda, K., Noguchi, T., Naguro, I., Ichijo, H.
- Journal Title
  
  Annu. Rev. Pharmacol. Toxicol. 48
  
  Pages: 199-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023013
[Journal Article] ALS-linked mutant SOD1 induces ER stress-and ASK1-dependent motor neuron death by targeting Derlin-1.2008
- Author(s)
  Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K. and Ichijo, H.
- Journal Title
  
  Genes Dev. 22
  
  Pages: 1451-1464
- Data Source
  KAKENHI-PROJECT-19390470
[Journal Article] ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.2008
- Author(s)
  Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K., Ichijo H.
- Journal Title
  
  Genes Dev. 22
  
  Pages: 1451-1464
- Data Source
  KAKENHI-PROJECT-20229004
[Journal Article] Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage.2008
- Author(s)
  Noguchi, T., et. al.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 7657-7665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18890061
[Journal Article] Apoptosis Signal-regulating Kinase 1 (ASK1) in stress and immune response2008
- Author(s)
  Takeda, K., Noguchi, T., Naguro, I. and Ichijo H.
- Journal Title
  
  Annu.Rev. Pharmacol.Toxicol.
  
  Volume: 48 Issue: 1 Pages: 199-225
- DOI
  10.1146/annurev.pharmtox.48.113006.094606
- Data Source
  KAKENHI-PROJECT-20229004
[Journal Article] Molecular Mechanism of Reactive Oxygen Species-dependent ASK1 Activation in Innate Immunity2008
- Author(s)
  Yamauchi, S., Noguchi, T. and Ichijo H.
- Journal Title
  
  Immune Network
  
  Volume: 8 Pages: 1-6
- Data Source
  KAKENHI-PROJECT-20229004
[Journal Article] Stress signaling in cancer.2007
- Author(s)
  Mucakami, S., Noguchi, T., Takeda, K., Ichijo, H.
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 1521-1527
- NAID
  10019997099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023013
[Journal Article] Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric complex with ASK1.2007
- Author(s)
  Takeda, K., Shimozono, R., Noguchi, T., Umeda, T., Morimoto, Y., Naguro, I., Tobiume, K., Saitoh, M., Matsuzawa, A. and Ichijo, H.
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 7522-7531
- Data Source
  KAKENHI-PROJECT-19390470
[Journal Article] Stress signaling in cancer.2007
- Author(s)
  Murakami, S., Noguchi, T., Takeda, K. and Ichijo, H.
- Journal Title
  
  Cancer Sci. (review article) 98
  
  Pages: 1521-1527
- NAID
  10019997099
- Data Source
  KAKENHI-PROJECT-19390470
[Journal Article] ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds.2007
- Author(s)
  Osaka, N., Takahashi, T., Murakami, S., Matsuzawa, A., Noguchi, T., Fujiwara, T., Aburatani, H., Moriyama, K., Takeda, K. and Ichijo, H.
- Journal Title
  
  J. Cell Biol. 176
  
  Pages: 903-909
- Data Source
  KAKENHI-PROJECT-19390470
[Journal Article] ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds.2007
- Author(s)
  Osaka, N., Takahashi, T., Murakami, S., Matsuzawa, A, Noguchi, T., Fujiwara, T., Aburatani, H., Moriyama, K., Takeda, K., Ichijo, H.
- Journal Title
  
  J. Cell Biol. 176
  
  Pages: 903-909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023013
[Journal Article] Thioredoxin and TRAF family proteins regulate ROS-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1.2007
- Author(s)
  Fujino, G., Noguchi, T., Matsuzawa, A., Yamauchi, S., Saitoh, M., Takeda, K., Ichijo, H.
- Journal Title
  
  Mol. Cell. Biol. 27
  
  Pages: 8152-8163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023013
[Journal Article] Thioredoxin and TRAF family proteins regulate ROS-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1.2007
- Author(s)
  Fujino, G., Noguchi, T., Matsuzawa, A., Yamauchi, S., Saitoh, M., Takeda, K. and Ichijo, H.
- Journal Title
  
  Mol. Cell. Biol. 27
  
  Pages: 8152-8163
- Data Source
  KAKENHI-PROJECT-19390470
[Journal Article] Apoptosis signal-regulating kinase2(ASK2)functions as a MAP3K in a heteromeric complex with ASK1.2007
- Author(s)
  Takeda, K., Shimozono, R., Noguchi, T., Umeda, T., Morimoto, Y., Naguro, I., Tobiume, K., Saitoh, M., Matsuzawa, A., Ichijo, H.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 7522-7531
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023013
[Journal Article] Pathophysiological roles of ASK1-MAP kinase signaling pathways.2007
- Author(s)
  Nagai, H., Noguchi, T., Takeda, K. and Ichijo, H.
- Journal Title
  
  J. Biochem. Mol.Biol.(review article) 40
  
  Pages: 1-6
- Data Source
  KAKENHI-PROJECT-19390470
[Journal Article] Pathophysiological Roles of ASK1-MAP Kinase Signaling Pathways.2007
- Author(s)
  Nagai, H., Noguchi, T., Takeda, K., Ichijo, H.
- Journal Title
  
  J. Biochem. Mol. Biol. 40
  
  Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023013
[Journal Article] Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage
- Author(s)
  Noguchi, T., Ishii, K., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K., Ichijo, H.
- Journal Title
  
  J. Biol. Chem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023013
[Presentation] Investigation of the Frequency-Regulated Repeated Micro-Vibration (FRMV) -mediated osteoblast differentiation mechanism in MC3T3-E1 cells2024
- Author(s)
  Ayumu Matsushita, Tada-aki Kudo, Yohei Hayashi, Kanako Tominami, Satoshi Izumi, Takakuni Tanaka, You-Ran Luo, Keiko Gengyo-Ando, Takuya Noguchi, Atsushi Matsuzawa, Guang Hong, Junichi Nakai
- Organizer
  第 101 回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-21K09929
[Presentation] 温度制御式反復温熱刺激を用いた骨芽細胞分化誘導法の開発2024
- Author(s)
  冨並香菜子, 工藤忠明, 林陽平, 泉哲, 松下歩夢, 羅悠然, 田中太邦, 安藤恵子, 野口拓也, 松沢厚, 洪光, 中井淳一
- Organizer
  第４５回東北骨代謝・骨粗鬆研究会
- Data Source
  KAKENHI-PROJECT-21K09929
[Presentation] 多機能分子p62/NBR1による液－液相分離（LLPS）を介した新たな癌転移抑制機構2023
- Author(s)
  野口拓也、松沢厚
- Organizer
  フォーラム2023：衛生薬学・環境トキシコロジー
- Invited
- Data Source
  KAKENHI-PROJECT-21H02691
[Presentation] 液－液相分離（LLPS）を介した新たな癌転移抑制機構2023
- Author(s)
  野口拓也
- Organizer
  Next Generation Symposium on Cell Signaling
- Invited
- Data Source
  KAKENHI-PROJECT-21H02691
[Presentation] A JNK inhibitor enhances thermal stimulation mediated neurite outgrowth in PC12-P1F1 cell2023
- Author(s)
  YouRan Luo, Tada-aki Kudo, Kanako Tominami, Satoshi Izumi, Yohei Hayashi, Takuiya Noguchi, Atsuhi Matsuzawa, Junichi Nakai, Guang Hong
- Organizer
  CA+inD International symposium 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09929
[Presentation] The effect of frequency-regulated repeated micro-vibration on osteoblast differentiation in MC3T3-E1 cells2023
- Author(s)
  Tada-aki Kudo , Guang Hong , Kanako Tominami , You-ran Luo , Satoshi Izumi , Takakuni Tanaka , Yohei Hayashi , Takuya Noguchi , Atsushi Matsuzawa , Junichi Nakai
- Organizer
  日本生理学会第１００回記念大会
- Data Source
  KAKENHI-PROJECT-21K09929
[Presentation] DNA 損傷応答におけるp62/SQSTM1液滴の役割2023
- Author(s)
  野口拓也
- Organizer
  第7回医薬品開発研究センターシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21H02691
[Presentation] SP600125 enhanced neurite outgrowth induced by temperature-controlled repeated thermal stimulation in PC12-P1F1 cells2022
- Author(s)
  Luo YR, Kudo T, Tominami K, Izumi S, Hayashi Y, Noguchi T, Matsuzawa A, Nakai J, Hong G
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-21K09929
[Presentation] A chemical compound SP600125 enhances neuritogenesis induced by temperature-controlled repeated thermal stimulation in PC12-P1F1 cells2022
- Author(s)
  You-Ran Luo, Tada-aki Kudo, Kanako Tominami, Satoshi Izumi, Yohei Hayashi, Takuya Noguchi, Atsushi Matsuzawa, Junichi Nakai, Guang Hong
- Organizer
  International Oral Health Symposium 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09929
[Presentation] Elucidation of the novel mechanisms by which gefitinib initiates inflammatory side effects2021
- Author(s)
  Tomohiro Kagi , Yuto Sekiguchi, Saya Takano, Yusuke Hirata, Takuya Noguchi, and Atsushi Matsuzawa
- Organizer
  International Graduate Student Conference in Pharmaceutical Sciences2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02691
[Presentation] Identification of the novel RING finger E3 ubiquitin ligase LINCR as a critical regulator of innate immune responses2021
- Author(s)
  Takumi Yokosawa, Yusuke Hirata, Takuya Noguchi, and Atsushi Matsuzawa
- Organizer
  International Graduate Student Conference in Pharmaceutical Sciences2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02691
[Presentation] The E3 ubiquitin-protein ligase RNF4 promotes TNF-α-induced cell death triggered by RIPK12021
- Author(s)
  Tatsuya Shimada, Tomohiro kagi, Midori Suzuki, Hiromu Komatsu, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa
- Organizer
  環境衛生フォーラム2021日韓次世代ポスターセッション
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02691
[Presentation] Involvement of the NLRP3 inflammasome in adverse drug reactions (ADRs)2021
- Author(s)
  Takuya Noguchi,　Atsushi Matsuzawa
- Organizer
  THE 6TH JAPAN-TAIWAN JOINT SYMPOSIUM FOR PHARMACEUTICAL SCIENCES
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02691
[Presentation] Induction of neuronal differentiation in PC12-P1F1 cells by frequency-regulated micro-vibration.2021
- Author(s)
  Luo YR, Kudo T, Tominami K, Izumi S, Hayashi Y, Noguchi T, Nakai J, Hong G
- Organizer
  FJMU-HKU-TU international symposium on oral health science 2021
- Data Source
  KAKENHI-PROJECT-21K09929
[Presentation] Establishment and characterization of neuron-like PC12-derived cell lines with hypersensitivity or hyposensitivity to temperature-regulated thermal stimulation (TRTS)2020
- Author(s)
  Tada-aki Kudo, Kanako Tominami, Satoshi Izumi, Yohei Hayashi, Takuya Noguchi, Guang Hong
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K11643
[Presentation] ゲノムワイドsiRNA ライブラリーを用いたアポトーシス調節キナーゼの探索2015
- Author(s)
  土田芽衣、野口拓也、平田祐介、松沢厚
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸学院大学ポートアイランドキャンパス
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-25460355
[Presentation] Fas 感受性を調節するキナーゼ群の探索2015
- Author(s)
  野口拓也、土田芽衣、平田祐介、松沢厚
- Organizer
  生化学会東北支部会
- Place of Presentation
  東北大学片平さくらホール
- Year and Date
  2015-05-09
- Data Source
  KAKENHI-PROJECT-25460355
[Presentation] ゲノムワイドsiRNAライブラリーを用いたアポトーシス調節キナーゼの探索2015
- Author(s)
  土田芽衣、野口拓也、平田祐介、松沢厚
- Organizer
  第14回次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉大学亥鼻キャンパス医薬系総合研究棟
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-25460355
[Presentation] 癌抑制遺伝子 STK11 による細胞死制御機構2014
- Author(s)
  野口拓也
- Organizer
  群馬大学・秋田大学　連携　第３回　生体情報研究シンポジウム～グローバルCOEプログラム「生体調節シグナルの統合的研究」の新展開～
- Place of Presentation
  秋田キャッスルホテル
- Year and Date
  2014-08-07
- Invited
- Data Source
  KAKENHI-PROJECT-25460355
[Presentation] Involvement of STK11 in TNF-induced cell death2014
- Author(s)
  熊澤琢也、野口拓也、徳永文稔
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-25460355
[Presentation] 癌抑制遺伝子STK11によるTNF2014
- Author(s)
  野口拓也
- Organizer
  大学院理工学府・生体調節研究所　第１９回　生命科学セミナー
- Place of Presentation
  群馬大学昭和キャンパス
- Year and Date
  2014-07-25
- Invited
- Data Source
  KAKENHI-PROJECT-25460355
[Presentation] Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage2008
- Author(s)
  Takuya Noguchi, et. al.
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18890061
[Presentation] ASK1-p38 pathway activated by NOX2-derived ROS is required for extracellular ATP-induced apoptosis in macroph2007
- Author(s)
  野口拓也, 他
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18890061
[Presentation] ATP誘導性アポトーシスにおけるASK1の役割2007
- Author(s)
  野口拓也, 他
- Organizer
  第30回日本分子生物学会年会、第80回日本生化学会大会合同大会(BMB2007)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18890061
[Presentation] ATP誘導性アポトーシスにおけるASK1の役割2007
- Author(s)
  野口拓也, 他
- Organizer
  第2回臨床ストレス応答学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18890061
[Presentation] ATP誘導性アポトーシスにおけるASK1の役割2007
- Author(s)
  野口拓也, 他
- Organizer
  第49回歯科基礎医学会学術大会・総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-18890061
[Presentation] 癌抑制遺伝子LKB1/STK11によるデスレセプターシグナルの制御機構
- Author(s)
  野口拓也
- Organizer
  新学術領域修飾シグナル第２回若手ワークショップ
- Place of Presentation
  伊香保温泉森秋旅館
- Data Source
  KAKENHI-PROJECT-25460355
[Presentation] デスレセプターを介したアポトーシスにおける癌抑制遺伝子STK11の関与
- Author(s)
  野口拓也
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸国際展示場1号館1階
- Data Source
  KAKENHI-PROJECT-25460355

1. NISHITOH Hideki (00332627)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. NAGURO Isao (80401222)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. TAKEDA Kohsuke (10313230)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
4. ICHIJO Hidenori (00242206)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
5. Kudo Tada-aki (50431606)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
6. 望月研太郎 (20633499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 冨並香菜子 (10815351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 出江紳一 (80176239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 金高弘恭 (50292222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 高木敏行 (20197065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 洪光 (70363083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
12. 林陽平 (00588056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
13. 松沢厚

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
14. 平田祐介

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
15. 斎藤芳郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Noguchi Takuya 野口 拓也

NOGUCHI Takuya 野口 拓也

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革新的転移抑制剤創出を見据えたp62/SQSTM液滴の病理的役割の解明Principal Investigator

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Elucidation of the physiological and pathological roles of LINCR in innate immune response with a view to creating drugs to treat sepsisPrincipal Investigator

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周波数制御式反復微細振動(FRMV)による神経細胞分化誘導とその分子的機序の検討

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Elucidation of balancing mechanisms of death receptor signaling mediated by STK11Principal Investigator

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Development of efficient and versatile method for inducing neuronal differentiation with temperature-controlled repeated thermal stimulation (TRTS)

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Elucidation of the phospho-dependent mechanisms of apoptosis inductionPrincipal Investigator

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小胞体品質管理におけるタンパク質分解の新規分子メカニズムの解明

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Drug development by the molecular mechanism-based analysis of stress signaling

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口腔疾患に関わるストレスシグナル解明への遺伝学的アプローチ

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Functional analysis of ASK2, a novel stress-responsive kinase, in carcinogenesis of oral squamous cell carcinomas

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異常蛋白質蓄積によるASK1シグナルを介した神経変性細胞死の分子病態の解明

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活性酸素種によるASK1活性化制御機構の解明Principal Investigator

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[Journal Article] The E3 Ubiquitin Protein Ligase LINCR Amplifies the TLR-Mediated Signals through Direct Degradation of MKP12024

Author(s)

Journal Title

Noguchi Takuya 野口拓也

NOGUCHI Takuya 野口拓也