SASAHARA KENJI 笹原健二

Researcher Number	20432495
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2020: 大阪大学, 蛋白質研究所, 特任講師(常勤) 2017: 大阪大学, たんぱく質研究所, 特任講師(常勤) 2013 – 2014: 神戸大学, 医学(系)研究科(研究院), 研究員 2012: 神戸大学, 医学(系)研究科(研究院), グローバルCOE研究員
Review Section/Research Field	Principal Investigator Biophysics / Basic Section 43020:Structural biochemistry-related
Keywords	Principal Investigator アミロイド / アモルファス凝集 / 揺らぎ / 蛋白質 / 蛋白質凝集 / アミロイドーシス / アミロイド線維 / 膜動態 / II型糖尿病 / 細胞毒性 … More / モデル脂質膜 / アミロイド凝集 / 膵島アミロイドポリペプチド / アミロイドβペプチド / モデル膜 / 脂質膜 Less

脂質膜上でのIAPPアミロイド凝集・沈着機構及びインスリンによる抑制機構の解明Principal Investigator
- Principal Investigator
  
  笹原健二
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Osaka University
Elucidation of thermal fluctuation associated with structural transition from amorphous aggregation to amyloid fibrillationPrincipal Investigator
- Principal Investigator
  
  SASAHARA KENJI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Osaka University
Effect of amyloid aggregation on dynamic properties of lipid membranesPrincipal Investigator
- Principal Investigator
  
  SASAHARA KENJI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Kobe University

All 2020 2019 2018 2017 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Isoelectric point-amyloid formation of α-synuclein extends the generality of the solubility and supersaturation-limited mechanism2020
- Author(s)
  Furukawa Koki、Aguirre Cesar、So Masatomo、Sasahara Kenji、Miyanoiri Yohei、Sakurai Kazumasa、Yamaguchi Keiichi、Ikenaka Kensuke、Mochizuki Hideki、Kardos Jozsef、Kawata Yasushi、Goto Yuji
- Journal Title
  
  Current Research in Structural Biology
  
  Volume: 2 Pages: 35-44
- DOI
  10.1016/j.crstbi.2020.03.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06352, KAKENHI-PUBLICLY-18H04557, KAKENHI-PROJECT-17K07363
[Journal Article] Heating during agitation of β2-microglobulin reveals that supersaturation breakdown is required for amyloid fibril formation at neutral pH2019
- Author(s)
  Noji Masahiro、Sasahara Kenji、Yamaguchi Keiichi、So Masatomo、Sakurai Kazumasa、Kardos Jazsef、Naiki Hironobu、Goto Yuji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 43 Pages: 15826-15835
- DOI
  10.1074/jbc.ra119.009971
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-17K07363
[Journal Article] Polyphosphates diminish solubility of a globular protein and thereby promote amyloid aggregation2019
- Author(s)
  Sasahara Kenji、Yamaguchi Keiichi、So Masatomo、Goto Yuji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 42 Pages: 15318-15329
- DOI
  10.1074/jbc.ra119.008662
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-17K07363
[Journal Article] Possible mechanisms of polyphosphate-induced amyloid fibril formation of β2-microglobulin2019
- Author(s)
  Zhang Chun-ming、Yamaguchi Keiichi、So Masatomo、Sasahara Kenji、Ito Toru、Yamamoto Suguru、Narita Ichiei、Kardos Jozsef、Naiki Hironobu、Goto Yuji
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 26 Pages: 12833-12838
- DOI
  10.1073/pnas.1819813116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-17K07363
[Journal Article] Aggregation-phase diagrams of β2-microglobulin reveal temperature and salt effects on competitive formation of amyloids versus amorphous aggregates2018
- Author(s)
  Masayuki Adachi, Masahiro Noji, Masatomo So, Kenji Sasahara, Jozsef Kardos, Hironobu Naiki, Yuji Goto
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 38 Pages: 14775-14785
- DOI
  10.1074/jbc.ra118.004683
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07363, KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-17K15074
[Journal Article] Heparin-dependent aggregation of hen egg white lysozyme reveals two distinct mechanisms of amyloid fibrillation2017
- Author(s)
  Nitani Ayame、Muta Hiroya、Adachi Masayuki、So Masatomo、Sasahara Kenji、Sakurai Kazumasa、Chatani Eri、Naoe Kazumitsu、Ogi Hirotsugu、Hall Damien、Goto Yuji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 52 Pages: 21219-21230
- DOI
  10.1074/jbc.m117.813097
- NAID
  120006557632
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07363, KAKENHI-PUBLICLY-16H00772, KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-15H04362, KAKENHI-PROJECT-16H04778, KAKENHI-PROJECT-15J03570, KAKENHI-PROJECT-17J01433, KAKENHI-PROJECT-15K07038
[Journal Article] Membrane-mediated amyloid deposition of human islet amyloid polypeptide2017
- Author(s)
  Sasahara Kenji
- Journal Title
  
  Biophysical Reviews
  
  Volume: 10 Issue: 2 Pages: 453-462
- DOI
  10.1007/s12551-017-0351-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07363
[Journal Article] Uptake of raft components into amyloid beta peptide aggregates and membrane damage2015
- Author(s)
  Kenji Sasahara, Kenichi Morigaki, Yasuko Mori
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 印刷中 Pages: 18-26
- DOI
  10.1016/j.ab.2015.04.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570185
[Journal Article] Transcriptome profiling of brain edemas caused by influenza infection and lipopolysaccharide treatment2014
- Author(s)
  Yukihiro Kyan, Yumi Ueda, Mitsutaka Yoshida, Kenji Sasahara, Kyoko Shinya
- Journal Title
  
  Journal of Medical Virology
  
  Volume: 86 Issue: 5 Pages: 905-911
- DOI
  10.1002/jmv.23801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570185
[Journal Article] PB1-F2 amino acids regulate influenza A viral polymerase activity2014
- Author(s)
  Yumi Ueda, Motoko Tanaka, Yukihiro Kyan, Mitsutaka Yoshida, Kenji Sasahara, Kyoko Shinya.
- Journal Title
  
  Joural of Basic and Applied Sciences
  
  Volume: 10 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570185
[Journal Article] Amyloid aggregation and deposition of human islet amyloid polypeptide at membrane interfaces2014
- Author(s)
  Kenji Sasahara, Kenichi Morigaki, Kyoko Shinya
- Journal Title
  
  FEBS Journal
  
  Volume: 印刷中 Issue: 11 Pages: 2597-2612
- DOI
  10.1111/febs.12807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570185, KAKENHI-PROJECT-26291031
[Journal Article] Effects of membrane interaction and aggregation of amyloid beta-peptide on lipid mobility and membrane domain structure2013
- Author(s)
  Sasahara K, Morigaki K, Shinya K
- Journal Title
  
  Physical Chemistry Chemical Physics
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570185
[Journal Article] Protease-dependent HA cleavage contributes to the alteration of chicken hemagglutination of the H3N2 influenza A virus2013
- Author(s)
  Masaoki Yamaoka, Akiko Makino, Kenji Sasahara, Aldise Mareta Nastri, Luh Ade Wilan Krisna, Edith Frederika Purhito, Emmanuel Djoko Poetranto, Laksmi Wulandari, Resti Yudhawati, Landia Setiawati, Retno Asih Setyoningrum, Kyoko Shinya
- Journal Title
  
  Japanese Journal of Infectious Diseases
  
  Volume: 66 Pages: 526-529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570185
[Journal Article] Application and use of differential scannning calorimetry in studies of thermal fluctuation associated with amyloid fibril formation2013
- Author(s)
  Sasahara K, Goto Y
- Journal Title
  
  Biophysical Reviews
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570185
[Journal Article] Binding of islet amyloid polypeptide to supported lipid bilayers and amyloid aggregation at the membranes2012
- Author(s)
  Sasahara K, Morigaki K, Okazaki T, Hamada D
- Journal Title
  
  Biochemistry
  
  Volume: 51 Pages: 6908-6919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570185
[Presentation] Amyloid aggregation of αsynuclein in the vicinity of solubility limit modulated by polyphosphate2019
- Author(s)
  Sasahara Kenji, Yamaguchi Keiichi, So Masatomo, Goto Yuji
- Organizer
  2019 Ulm Meeting - Biophysics of Amyloid Formation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07363
[Presentation] Mechanism of polyphosphate-induced aggregation of a globular protein2019
- Author(s)
  笹原健二、山口圭一、宗正智、後藤祐児
- Organizer
  第92回日本生化学会
- Data Source
  KAKENHI-PROJECT-17K07363
[Presentation] Amyloid aggregation of α-synuclein in the vicinity of solubility limit modulated by polyphosphate2019
- Author(s)
  Sasahara Kenji, Yamaguchi Keiichi, So Masatomo, Goto Yuji
- Organizer
  Ulm Meeting - Biophysics of Amyloid Formation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07363
[Presentation] Amyloid aggregation of α-synuclein near solubility limit modulated by polyphosphate2019
- Author(s)
  笹原健二、山口圭一、宗正智、河田康志、後藤祐児
- Organizer
  第19回日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-17K07363
[Presentation] Polyphosphate-induced aggregation of hen lysozyme2019
- Author(s)
  笹原健二、山口圭一、宗正智、後藤祐児
- Organizer
  第57回日本生物物理学会
- Data Source
  KAKENHI-PROJECT-17K07363
[Presentation] αシヌクレインアミロイド線維形成を促進及び抑制する溶液条件2018
- Author(s)
  笹原健二、山口圭一、宗正智、後藤祐児
- Organizer
  第6回日本アミロイドーシス研究会学術集会
- Data Source
  KAKENHI-PROJECT-17K07363
[Presentation] Competition between amyloid fibrillation and amorphous aggregation of αsynuclein2018
- Author(s)
  笹原健二、山口圭一、宗正智、河田康志、後藤祐児
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K07363
[Presentation] 超音波照射下におけるポリリン酸が促進するαシヌクレインのアミロイド線維形成2017
- Author(s)
  山口圭一、藤川龍弥、宗正智、笹原健二、河田康志、後藤祐児
- Organizer
  第26回ソノケミストリー討論会
- Data Source
  KAKENHI-PROJECT-17K07363
[Presentation] 超音波照射によるαシヌクレインアミロイド核の伸長を促進する溶液条件2017
- Author(s)
  笹原健二、山口圭一、宗正智、後藤祐児
- Organizer
  第26回ソノケミストリー討論会
- Data Source
  KAKENHI-PROJECT-17K07363
[Presentation] Interaction of amyloid with lipid membranes2015
- Author(s)
  Kenji Sasahara
- Organizer
  Institute for Protein Research Seminar
- Place of Presentation
  大阪大学蛋白質研究所
- Year and Date
  2015-02-05
- Invited
- Data Source
  KAKENHI-PROJECT-24570185
[Presentation] Dynamic Association of IAPP aggregates with lipids and amyloid deposition2014
- Author(s)
  笹原健二、新矢恭子
- Organizer
  新学術領域　動的秩序と機能
- Place of Presentation
  キャンパスプラザ京都
- Data Source
  KAKENHI-PROJECT-24570185
[Presentation] Characterization of membrane-mediated IAPP aggregation2013
- Author(s)
  笹原　健二、新矢　恭子
- Organizer
  第１3回日本蛋白質科学会年会
- Place of Presentation
  とりぎん文化ホール（鳥取）
- Data Source
  KAKENHI-PROJECT-24570185
[Presentation] モデル脂質膜上でのIAPPアミロイド沈着2013
- Author(s)
  笹原健二、新矢恭子
- Organizer
  第12回日本蛋白質科学会
- Place of Presentation
  鳥取文化会館
- Data Source
  KAKENHI-PROJECT-24570185
[Presentation] Amyloid deposition of islet amyloid polypeptide on model membranes2013
- Author(s)
  笹原健二、新矢恭子
- Organizer
  第８６回日本生化学会年回
- Place of Presentation
  横浜国際会議場
- Data Source
  KAKENHI-PROJECT-24570185
[Presentation] Establishment of methodology to evaluate the effectiveness of anti-influenza drug2012
- Author(s)
  笹原　健二、永江　倫子、新矢　恭子
- Organizer
  第８５回日本生化学会大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24570185
[Presentation] Effects of raft composition on the membrane-mediated aggregation of IAPP2012
- Author(s)
  笹原　健二、新矢　恭子
- Organizer
  第５０回日本生物物理学会年会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-24570185
[Presentation] 脂質膜上でのIAPP凝集と脂質組成の効果2012
- Author(s)
  笹原　健二、新矢　恭子、森垣　憲一
- Organizer
  第１２回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-24570185
[Presentation] Observation of amyloid aggregates associated with lipids of amyloid beta peptides
- Author(s)
  Kenji Sasahara
- Organizer
  日本生物物理学会年会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24570185

1. MORIGAKI Kenichi (10358179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 後藤祐児

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

SASAHARA KENJI 笹原 健二

Research Projects

Research Products

Co-Researchers

脂質膜上でのIAPPアミロイド凝集・沈着機構及びインスリンによる抑制機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of thermal fluctuation associated with structural transition from amorphous aggregation to amyloid fibrillationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of amyloid aggregation on dynamic properties of lipid membranesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Isoelectric point-amyloid formation of α-synuclein extends the generality of the solubility and supersaturation-limited mechanism2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Heating during agitation of β2-microglobulin reveals that supersaturation breakdown is required for amyloid fibril formation at neutral pH2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polyphosphates diminish solubility of a globular protein and thereby promote amyloid aggregation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible mechanisms of polyphosphate-induced amyloid fibril formation of β2-microglobulin2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aggregation-phase diagrams of β2-microglobulin reveal temperature and salt effects on competitive formation of amyloids versus amorphous aggregates2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Heparin-dependent aggregation of hen egg white lysozyme reveals two distinct mechanisms of amyloid fibrillation2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Membrane-mediated amyloid deposition of human islet amyloid polypeptide2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Uptake of raft components into amyloid beta peptide aggregates and membrane damage2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptome profiling of brain edemas caused by influenza infection and lipopolysaccharide treatment2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PB1-F2 amino acids regulate influenza A viral polymerase activity2014

Author(s)

Journal Title

Data Source

[Journal Article] Amyloid aggregation and deposition of human islet amyloid polypeptide at membrane interfaces2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of membrane interaction and aggregation of amyloid beta-peptide on lipid mobility and membrane domain structure2013

Author(s)

Journal Title

SASAHARA KENJI 笹原健二