Kawai Akito 河合聡人

Researcher Number	20435150
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 藤田医科大学, 医学部, 講師 2020: 藤田医科大学, 医学部, 助教 2018: 藤田医科大学, 医学部, 助教 2015 – 2017: 崇城大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Risk sciences of radiation and chemicals
Keywords	Principal Investigator X線結晶構造解析 / β-ラクタマーゼ阻害薬 / β-ラクタム薬 / 薬剤耐性細菌 / 分子動力学計算 / 酵素速度論解析 / β-ラクタマーゼ / 抗菌薬耐性 / 血漿タンパク結合 / アルブミン … More / 薬剤感受性試験 / 抗菌薬 / 薬剤感受性 / ヒト血清アルブミン / 構造生物学 / DNAクランプ / DNA相同組換え / タンパク質の結晶化 Less

Structural enzymological study for the optimization of the combinations of beta-lactam and beta-lactamase inhibitorPrincipal Investigator
- Principal Investigator
  
  河合聡人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Fujita Health University
Structure based study of human serum albumin complex with antibiotics to improve the multidrug antimicrobial therapy.Principal Investigator
- Principal Investigator
  
  Kawai Akito
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Fujita Health University
Regulation of DNA clamp reactions involved in DNA recombinationPrincipal Investigator
- Principal Investigator
  
  Kawai Akito
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Fujita Health University
  Sojo University

All 2024 2023 2022 2021 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Structural insights into the molecular mechanism of high-level ceftazidime?avibactam resistance conferred by CMY-1852024
- Author(s)
  Kawai Akito、Shropshire William C.、Suzuki Masahiro、Borjan Jovan、Aitken Samuel L.、Bachman William C.、McElheny Christi L.、Bhatti Micah M.、Shields Ryan K.、Shelburne Samuel A.、Doi Yohei
- Journal Title
  
  mBio
  
  Volume: 15 Issue: 2
- DOI
  10.1128/mbio.02874-23
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06267
[Journal Article] High-level ceftazidime/avibactam resistance in<i>Escherichia coli</i>conferred by the novel plasmid-mediated β-lactamase CMY-185 variant2023
- Author(s)
  Shropshire William C、Endres Bradley T、Borjan Jovan、Aitken Samuel L、Bachman William C、McElheny Christi L、Wu Chin-Ting、Egge Stephanie L、Khan Ayesha、Miller William R、Bhatti Micah M、Saharasbhojane Pranoti、Kawai Akito、Shields Ryan K、Shelburne Samuel A、Doi Yohei
- Journal Title
  
  Journal of Antimicrobial Chemotherapy
  
  Volume: 78 Issue: 10 Pages: 2442-2450
- DOI
  10.1093/jac/dkad249
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06267
[Journal Article] Effects of Myristate on the Induced Circular Dichroism Spectra of Aripiprazole Bound to Human Serum Albumin: A Structural?Chemical Investigation2022
- Author(s)
  Hirata Kenshiro、Kawai Akito、Chuang Victor Tuan Giam、Sakurama Keiki、Nishi Koji、Yamasaki Keishi、Otagiri Masaki
- Journal Title
  
  ACS Omega
  
  Volume: 7 Issue: 5 Pages: 4413-4419
- DOI
  10.1021/acsomega.1c06220
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16060, KAKENHI-PROJECT-20K06995
[Journal Article] Structural Basis of the Change in the Interaction Between Mycophenolic Acid and Subdomain IIA of Human Serum Albumin During Renal Failure2022
- Author(s)
  Yamasaki Keishi、Teshima Honoka、Yukizawa Reina、Kuyama Koki、Tsukigawa Kenji、Nishi Koji、Otagiri Masaki、Kawai Akito
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 66 Issue: 1 Pages: 951-961
- DOI
  10.1021/acs.jmedchem.2c01790
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16060, KAKENHI-PROJECT-20K06995
[Journal Article] Chlorine Atoms of an Aripiprazole Molecule Control the Geometry and Motion of Aripiprazole and Deschloro-aripiprazole in Subdomain IIIA of Human Serum Albumin2022
- Author(s)
  Kawai Akito、Kobashigawa Yoshihiro、Hirata Kenshiro、Morioka Hiroshi、Imoto Shuhei、Nishi Koji、Chuang Victor Tuan Giam、Yamasaki Keishi、Otagiri Masaki
- Journal Title
  
  ACS Omega
  
  Volume: 7 Issue: 34 Pages: 29944-29951
- DOI
  10.1021/acsomega.2c02929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16060, KAKENHI-PROJECT-20K06995
[Journal Article] Functional and Structural Characterization of Acquired 16S rRNA Methyltransferase NpmB1 Conferring Pan-Aminoglycoside Resistance2021
- Author(s)
  Kawai Akito、Suzuki Masahiro、Tsukamoto Kentaro、Minato Yusuke、Doi Yohei
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 65 Issue: 10
- DOI
  10.1128/aac.01009-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07548, KAKENHI-PROJECT-20K16060
[Journal Article] Interaction of Benzbromarone with Subdomains IIIA and IB/IIA on Human Serum Albumin as the Primary and Secondary Binding Regions2021
- Author(s)
  Yamasaki Keishi、Kawai Akito、Sakurama Keiki、Udo Nagiko、Yoshino Yuta、Saito Yuki、Tsukigawa Kenji、Nishi Koji、Otagiri Masaki
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 18 Issue: 3 Pages: 1061-1070
- DOI
  10.1021/acs.molpharmaceut.0c01004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06810, KAKENHI-PROJECT-20K16060, KAKENHI-PROJECT-20K06995
[Journal Article] Crystal structure analysis of human serum albumin complexed with sodium 4-phenylbutyrate.2018
- Author(s)
  Kawai A, Yamasaki K, Enokida T, Miyamoto S, Otagiri M.
- Journal Title
  
  Biochem Biophys Rep
  
  Volume: 13 Pages: 78-82
- DOI
  10.1016/j.bbrep.2018.01.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08261, KAKENHI-PROJECT-15K16128
[Journal Article] Analysis of the binding of aripiprazole to human serum albumin: The importance of a chloro-group in the chemical structure.2018
- Author(s)
  Sakurama K, Kawai A, Tuan Giam Chuang V, Kanamori Y, Osa M, Taguchi K, Seo H, Maruyama T, Imoto S, Yamasaki K, Otagiri M
- Journal Title
  
  ACS Omega
  
  Volume: 3 Issue: 10 Pages: 13790-13797
- DOI
  10.1021/acsomega.8b02057
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08261, KAKENHI-PROJECT-15K16128
[Journal Article] Crystallographic analysis of the ternary complex of octanoate and N-acetyl-l-methionine with human serum albumin reveals the mode of their stabilizing interactions.2017
- Author(s)
  Kawai A, Chuang VTG, Kouno Y, Yamasaki K, Miyamoto S, Anraku M, Otagiri M.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1865 Issue: 8 Pages: 979-984
- DOI
  10.1016/j.bbapap.2017.04.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08261, KAKENHI-PROJECT-17K08480, KAKENHI-PROJECT-15K16128
[Journal Article] Species Differences in the Binding of Sodium 4-Phenylbutyrate to Serum Albumin.2017
- Author(s)
  Yamasaki K, Enokida T, Taguchi K, Miyamura S, Kawai A, Miyamoto S, Maruyama T, Seo H, Otagiri M.
- Journal Title
  
  J Pharm Sci
  
  Volume: 106 Issue: 9 Pages: 2860-2867
- DOI
  10.1016/j.xphs.2017.04.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08261, KAKENHI-PROJECT-15K16128
[Journal Article] Crystal structure of family 4 uracil-DNA glycosylase from Sulfolobus tokodaii and a function of tyrosine 170 in DNA binding2015
- Author(s)
  Kawai A., Higuchi S., Tsunoda M., Nakamura K.T., Yamagata Y., Miyamoto S.
- Journal Title
  
  FEBS Letters
  
  Volume: 589 Issue: 19PartB Pages: 2675-2682
- DOI
  10.1016/j.febslet.2015.08.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K16128
[Presentation] N346Y変異型AmpC β-ラクタマーゼの基質特異性変化の分子構造基盤2024
- Author(s)
  河合聡人、土井洋平
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06267
[Presentation] セフタジジム－アビバクタム合剤治療中に単離された大腸菌が有したβ-ラクタマーゼの構造生物学研究2023
- Author(s)
  河合聡人、土井洋平
- Organizer
  フジタEXPO2023
- Data Source
  KAKENHI-PROJECT-23K06267
[Presentation] ヒト血清アルブミンとアリピプラゾール誘導体の誘起CDスペクトル変化に関する構造生物化学的考察2023
- Author(s)
  河合聡人 , 小橋川敬博 , 平田憲史郎 , 森岡弘志 , 井本修平 , 西弘二 , 山崎啓之 , 小田切優樹
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K16060
[Presentation] CMY-185によるセフタジジムーアビバクタム高度耐性化機構の検討2023
- Author(s)
  河合聡人、土井洋平
- Organizer
  第52回薬剤耐性菌研究会
- Data Source
  KAKENHI-PROJECT-23K06267
[Presentation] ファミリー4 ウラシルDNAグリコシラーゼによる酵素触媒機構の解明2018
- Author(s)
  河合聡人, 吉田紀生, 中村照也, 下野和実, 山縣ゆり子, 宮本秀一
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15K16128
[Presentation] ヒト血清アルブミンを安定化する低分子化合物の構造化学研究2018
- Author(s)
  河合聡人、安楽誠、河野陽介、宮本秀一、山崎啓之、小田切優樹
- Organizer
  第16回次世代を担う若手のためのフィジカル・ファーマフォーラム（PPF2018）
- Data Source
  KAKENHI-PROJECT-15K16128
[Presentation] ファミリー4 ウラシルDNAグリコシラーゼ-DNA複合体の立体構造に基づく酵素反応機構の解明2017
- Author(s)
  河合聡人, 中村照也, 山縣ゆり子, 宮本秀一
- Organizer
  2016年度量子ビームサイエンスフェスタ
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2017-03-14
- Data Source
  KAKENHI-PROJECT-15K16128
[Presentation] 立体構造に基づくオクタン酸ナトリウム及びN-アセチル-L-メチオニンのヒト血清アルブミン安定化効果に関する考察2017
- Author(s)
  河合聡人, 安楽誠, 河野陽介, 宮本秀一, 山崎啓之, 小田切優樹
- Organizer
  第34回日本薬学会九州支部大会
- Data Source
  KAKENHI-PROJECT-15K16128
[Presentation] 立体構造に基づくヒト血清アルブミンに対するN-アセチル-L-メチオニンの抗酸化効果に関する考察2017
- Author(s)
  河合聡人, 安楽誠, 河野陽介, 宮本秀一, 山崎啓之, 小田切優樹
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15K16128
[Presentation] ファミリー4 ウラシルDNAグリコシラーゼ-DNA複合体の結晶構造解析2017
- Author(s)
  河合聡人, 中村照也, 下野和実, 山縣ゆり子, 宮本秀一
- Organizer
  第55回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-15K16128
[Presentation] 立体構造に基づくアルブミン製剤に添加する安定化剤の有用性に関する考察2016
- Author(s)
  河合聡人, 安楽誠, 河野陽介, 宮本秀一, 小田切優樹
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場(福岡県福岡市)
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K16128
[Presentation] ファミリー4 ウラシルDNAグリコシラーゼとDNAの複合体構造解析2016
- Author(s)
  河合聡人, 中村照也, 山縣ゆり子, 宮本秀一
- Organizer
  2015年度量子ビームサイエンスフェスタ
- Place of Presentation
  つくば国際会議場 (茨城県つくば市)
- Year and Date
  2016-03-15
- Data Source
  KAKENHI-PROJECT-15K16128
[Presentation] ヒト血清アルブミン-オクタン酸ナトリウム-N-アセチル－Ｌ-メチオニン三元複合体のX線結晶構造解析2016
- Author(s)
  小田切優樹, 河合聡人, 河野陽介, 宮本秀一, 山崎啓之, 安楽誠
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K16128
[Presentation] ファミリー4 ウラシルDNAグリコシラーゼによるDNA認識機構の解明2015
- Author(s)
  河合聡人, 中村照也, 山縣ゆり子, 宮本秀一
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール (徳島県徳島市)
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15K16128

1. YAMASAKI Keishi

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
2. TSUKAMOTO Kentaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 小田切優樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawai Akito 河合 聡人

Research Projects

Research Products

Co-Researchers

Structural enzymological study for the optimization of the combinations of beta-lactam and beta-lactamase inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure based study of human serum albumin complex with antibiotics to improve the multidrug antimicrobial therapy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of DNA clamp reactions involved in DNA recombinationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structural insights into the molecular mechanism of high-level ceftazidime?avibactam resistance conferred by CMY-1852024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-level ceftazidime/avibactam resistance in<i>Escherichia coli</i>conferred by the novel plasmid-mediated β-lactamase CMY-185 variant2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of Myristate on the Induced Circular Dichroism Spectra of Aripiprazole Bound to Human Serum Albumin: A Structural?Chemical Investigation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural Basis of the Change in the Interaction Between Mycophenolic Acid and Subdomain IIA of Human Serum Albumin During Renal Failure2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chlorine Atoms of an Aripiprazole Molecule Control the Geometry and Motion of Aripiprazole and Deschloro-aripiprazole in Subdomain IIIA of Human Serum Albumin2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional and Structural Characterization of Acquired 16S rRNA Methyltransferase NpmB1 Conferring Pan-Aminoglycoside Resistance2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interaction of Benzbromarone with Subdomains IIIA and IB/IIA on Human Serum Albumin as the Primary and Secondary Binding Regions2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structure analysis of human serum albumin complexed with sodium 4-phenylbutyrate.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of the binding of aripiprazole to human serum albumin: The importance of a chloro-group in the chemical structure.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystallographic analysis of the ternary complex of octanoate and N-acetyl-l-methionine with human serum albumin reveals the mode of their stabilizing interactions.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Species Differences in the Binding of Sodium 4-Phenylbutyrate to Serum Albumin.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structure of family 4 uracil-DNA glycosylase from Sulfolobus tokodaii and a function of tyrosine 170 in DNA binding2015

Author(s)

Journal Title

Kawai Akito 河合聡人