Kobayashi Tetsu 小林哲

… Alternative Names

KOBAYASHI Tetsu 小林哲

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Researcher Number	20437114
Other IDs
Affiliation (Current)	2025: 三重大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 三重大学, 医学系研究科, 教授 2017 – 2022: 三重大学, 医学部附属病院, 准教授 2015: 三重大学, 医学部附属病院, 准教授 2011 – 2014: 三重大学, 医学部附属病院, 講師 2011: 三重大学, 医学部付属病院, 講師 … More 2010: 三重大学, 医学附属病院, 助教 2009 – 2010: 三重大学, 医学部附属病院, 助教 2008: Mie University, 医学部・附属病院, 医員 2007 – 2008: Mie University, 医学部附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine / Environmental pharmacy
Keywords	Principal Investigator 肺線維症 / siRNA / TGF-β / RNAi / 線維芽細胞 / 線維化 / 肺癌 / 呼吸器 / マイクロバイオーム / 細菌叢 … More / TGF / リモデリング / 気道リモデリング / 上皮間葉移行 / EMT … More Except Principal Investigator 細菌叢 / corisin / 肺線維症 / サイトカイン / 肺気腫 / コリシン / アポトーシス / 肺内細菌叢 / 成長因子 / TGFbeta1 / MUC5B / ブレオマイシン / ムチン / ケモカイン / マウスモデル / COPD / 肺傷害 / 気管支炎 / プロテアーゼ / 炎症性サイトカイン / 煙草 / COVID-19 / 抗corisin抗体 / 呼吸不全 / ELISA法 / 肺疾患 / ムチン過剰発現 / 急性肺障害 / 細胞死誘導因子 / TGFΒ1 / MUC5Bタンパク / トランスジェニックマウス / 抗コリシン抗体 / 細胞死因子 / 急性増悪 / 予後 / 抗線維化剤 / 細胞死 / 遺伝子変異 / 遺伝子改変マウス / rs35705950単塩基多型 / コラーゲン / PCR成長因子 / トランジェニックマウス / 16S RNA / TGF-β / microbiome / fibrosis / IPF / 核酸医薬 / 転写因子 / 慢性炎症性疾患 / プロテアーゼ阻害剤 / ヒトマトリックスメタロプロテアーゼ / タバコ煙 / 難病 / MMP-2 / RNA干渉 / NF-kappaB / 細胞内伝達機構 / トロンビン / 慢性気管支炎 / T細胞 / トロンビン受容体 / 凝固系 / 活性化プロテインC / 肺胞上皮細胞傷害 / 凝固系因子 / 血管内皮細胞傷害 / タバコ / 慢性閉塞性肺疾患 / 活性かプロテインC / マトリックスメタロプロテーゼ / 樹状細胞 / 炎症性細胞 / 肺胞破壊 / 高齢者 / 閉塞性肺疾患 Less

細菌叢由来ペプチドによる肺線維症発症メカニズム解明と抑制方法の開発Principal Investigator
- Principal Investigator
  
  小林哲
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Mie University
COVID-19における肺傷害促進因子Corisinの検討
- Principal Investigator
  
  藤本源
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Mie University
The role of the lung microbiota-derived proapoptotic peptide (corisin) in COPD
- Principal Investigator
  
  GABAZZA CORINA
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Mie University
Microbiome in the Development of Lung CancerPrincipal Investigator
- Principal Investigator
  
  Kobayashi Tetsu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Mie University
Investigating the role of mucin in pulmonary fibrosis-associated microbiota dysbiosis using MUC5B overexpressing mice
- Principal Investigator
  
  Gabazza Esteban
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Mie University
Evaluating the role of the lung microbiome in pulmonary fibrosis
- Principal Investigator
  
  NAKAHARA Hiroki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Mie University
Development of novel therapeutic approaches for pulmonary fibrosis using MUC5B overexpressing mice
- Principal Investigator
  
  Taguchi Osamu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Mie University
RNAi for the treatment of refractory pulmonary diseasesPrincipal Investigator
- Principal Investigator
  
  Kobayashi Tetsu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Mie University
Development of new therapeutic strategies for chronic obstructive diseases using RNA interference
- Principal Investigator
  
  GABAZZA Esteban
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Mie University
siRNA for the treatment of airway remodelingPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Tetsu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Mie University
EVALUATING THE PATHOGENESIS AND DEVELOPMENT OF NOVEL THERAPIES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE USING GENE-ENGINEERED MICE
- Principal Investigator
  
  TAGUCHI Osamu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Mie University
Epithelial mesenchymal transition during airway remodelingPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Tetsu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Mie University

[Book] Annual Review 2016 呼吸器2016
- Author(s)
  小林　哲、ガバザ　エステバン
- Total Pages
  6
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-25461189
[Journal Article] Close-to-lesion transbronchial biopsy: a novel technique to improve suitability of specimens for genetic testing in patients with peripheral pulmonary lesions2023
- Author(s)
  Nishii Y, Sakaguchi T, Esumi S, Esumi M, Nakamura Y, Suzuki Y, Ito K, Fujiwara K, Yasui H, Ito A, Tarukawa T, Tsuruga T, D'Alessandro-Gabazza CN, Yasuma T, Fujimoto H, Asano F, Gabazza EC, Kobayashi T, Taguchi O, Hataji O.
- Journal Title
  
  Sci Rep.
  
  Volume: 13 Issue: 1 Pages: 14724-14724
- DOI
  10.1038/s41598-023-41726-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08203
[Journal Article] Epoprostenol and Treprostinil: Differential Effects on Regulatory T-Cell Generation in Patients with Pulmonary Arterial Hypertension2023
- Author(s)
  Yasuma Taro、Fujimoto Hajime、D’Alessandro-Gabazza Corina N.、Gabazza Esteban C.、Hataji Osamu、Kobayashi Tetsu
- Journal Title
  
  American Journal of Respiratory and Critical Care Medicine
  
  Volume: 208 Issue: 11 Pages: 1248-1248
- DOI
  10.1164/rccm.202308-1347le
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07651, KAKENHI-PROJECT-21K08203
[Journal Article] Elevated plasma and bile levels of corisin, a microbiota-derived proapoptotic peptide, in patients with severe acute cholangitis2023
- Author(s)
  Nishiwaki R, Imoto I, Oka S, Yasuma T, Fujimoto H, D'Alessandro-Gabazza CN, Toda M, Kobayashi T, Osamu H, Fujibe K, Nishikawa K, Hamaguchi T, Sugimasa N, Noji M, Ito Y, Takeuchi K, Cann I, Inoue Y, Kato T, Gabazza EC.
- Journal Title
  
  Gut Pathog.
  
  Volume: 15 Issue: 1 Pages: 59-59
- DOI
  10.1186/s13099-023-00587-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08203
[Journal Article] Inhibition of a Microbiota-Derived Peptide Ameliorates Established Acute Lung Injury2023
- Author(s)
  D'Alessandro Fridman V, D'Alessandro-Gabazza CN, Yasuma T, Toda M, Takeshita A, Tomaru A, Tharavecharak S, Lasisi IO, Hess RY, Nishihama K, Fujimoto H, Kobayashi T, Cann I, Gabazza EC.
- Journal Title
  
  American Journal of Pathology
  
  Volume: 23 Issue: 6 Pages: 740-754
- DOI
  10.1016/j.ajpath.2023.03.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08280, KAKENHI-PROJECT-20K08564, KAKENHI-PROJECT-21K16116, KAKENHI-PROJECT-21K16160, KAKENHI-PROJECT-23K15206, KAKENHI-PROJECT-21K08203, KAKENHI-PROJECT-21K16185
[Journal Article] Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression.2023
- Author(s)
  Inoue R, Yasuma T, Fridman D'Alessandro V, Toda M, Ito T, Tomaru A, D'Alessandro-Gabazza CN, Tsuruga T, Okano T, Takeshita A, Nishihama K, Fujimoto H, Kobayashi T, Gabazza EC.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 24(7) Issue: 7 Pages: 6695-6695
- DOI
  10.3390/ijms24076695
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15206, KAKENHI-PROJECT-23K07651, KAKENHI-PROJECT-21K08203
[Journal Article] Is Helicobacter pylori infection inversely correlated with atopic, skin, and autoimmune diseases?2022
- Author(s)
  Yasuma T, D'Alessandro-Gabazza CN, Fujimoto H, Kobayashi T, Imoto I, Gabazza EC.
- Journal Title
  
  Allergy
  
  Volume: 77 Issue: 10 Pages: 3165-3166
- DOI
  10.1111/all.15306
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08280, KAKENHI-PROJECT-20K08564
[Journal Article] Response of Lung Microbiota to Changes of Pulmonary Innate Immunity under Healthy Conditions2022
- Author(s)
  Yasuma Taro、D’Alessandro-Gabazza Corina N.、Fujimoto Hajime、Kobayashi Tetsu、Gabazza Esteban C.
- Journal Title
  
  American Journal of Respiratory and Critical Care Medicine
  
  Volume: 205 Issue: 4 Pages: 477-477
- DOI
  10.1164/rccm.202109-2187le
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08564, KAKENHI-PROJECT-21K08203
[Journal Article] Correlation of total serum HDL particles with a predictor of mortality risk in idiopathic pulmonary fibrosis2022
- Author(s)
  Yasuma T, D'Alessandro-Gabazza CN, Fujimoto H, Kobayashi T, Gabazza EC.
- Journal Title
  
  European Respiratory Journal
  
  Volume: 59 Issue: 4 Pages: 2103175-2103175
- DOI
  10.1183/13993003.03175-2021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08564
[Journal Article] Microbial Burden-associated Cytokine Storm May Explain Nonresolving Acute Respiratory Distress Syndrome in Patients with COVID-192022
- Author(s)
  Yasuma T, D'Alessandro-Gabazza CN, Kobayashi T, Gabazza EC, Fujimoto H.
- Journal Title
  
  Am J Respir Crit Care Med .
  
  Volume: 206 Issue: 9 Pages: 1182-1183
- DOI
  10.1164/rccm.202207-1266le
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08203
[Journal Article] Transforming Growth Factorβ1 Overexpression Is Associated with Insulin Resistance and Rapidly Progressive Kidney Fibrosis under Diabetic Conditions.2022
- Author(s)
  D'Alessandro VF, Takeshita A, Yasuma T, Toda M, D'Alessandro-Gabazza CN, Okano Y, Tharavecharak S, Inoue C, Nishihama K, Fujimoto H, Kobayashi T, Yano Y, Gabazza EC.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 23 Issue: 22 Pages: 146251-19
- DOI
  10.3390/ijms232214265
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08256, KAKENHI-PROJECT-22K08280, KAKENHI-PROJECT-21K16185, KAKENHI-PROJECT-21K16160
[Journal Article] Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis.2022
- Author(s)
  D'Alessandro-Gabazza CN, Yasuma T, Kobayashi T, Toda M, Abdel-Hamid AM, Fujimoto H, Hataji O, Nakahara H, Takeshita A, Nishihama K, Okano T, Saiki H, Okano Y, Tomaru A, D'Alessandro VF, Shiraishi M, Mizoguchi A, Ono R, Ohtsuka J, Fukumura M, Nosaka T, et al. & Gabazza EC
- Journal Title
  
  Nat Commun
  
  Volume: 13 Issue: 1 Pages: 1558-1558
- DOI
  10.1038/s41467-022-29064-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03529, KAKENHI-PROJECT-20K08564, KAKENHI-PROJECT-21K08256, KAKENHI-PROJECT-21K08411, KAKENHI-PROJECT-20K21614, KAKENHI-PROJECT-21K08203, KAKENHI-PROJECT-21K16185, KAKENHI-PROJECT-21K16116, KAKENHI-PROJECT-21K16160
[Journal Article] A Microbiome-Derived Peptide Induces Apoptosis of Cells from Different Tissues2021
- Author(s)
  Saiki Haruko、Okano Yuko、Yasuma Taro、Toda Masaaki、Takeshita Atsuro、Abdel-Hamid Ahmed M.、Fridman D’Alessandro Valeria、Tsuruga Tatsuki、D’Alessandro-Gabazza Corina N.、Katayama Kan、Sugimoto Masahiko、Fujimoto Hajime、Yamanaka Keiichi、Kobayashi Tetsu、Cann Isaac、Gabazza Esteban C.
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 11 Pages: 2885-2885
- DOI
  10.3390/cells10112885
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08564, KAKENHI-PROJECT-21K08203, KAKENHI-PROJECT-21K16185
[Journal Article] The role of cigarette smoking-derived pollutants in the risk of mortality in idiopathic pulmonary fibrosis2021
- Author(s)
  Yasuma Taro、D'Alessandro-Gabazza Corina N.、Hataji Osamu、Kobayashi Tetsu、Gabazza Esteban C.
- Journal Title
  
  European Respiratory Journal
  
  Volume: 58 Issue: 3 Pages: 2101372-2101372
- DOI
  10.1183/13993003.01372-2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08203
[Journal Article] The Potential of Digital Polymerase Chain Reaction for Improving Diagnostic Yield of Nontuberculous Mycobacteria Pulmonary Disease2021
- Author(s)
  Nishii Yoichi、Furuhashi Kazuki、Nakamura Saki、Nishio Miho、Nakamura Yuki、Ushiro Kengo、Ito Kentaro、Sakaguchi Tadashi、Suzuki Yuta、Fujiwara Kentaro、Yasuma Taro、Kobayashi Tetsu、D'Alessandro-Gabazza Corina、Gabazza Esteban C、Taguchi Osamu、Hataji Osamu
- Journal Title
  
  Infection and Drug Resistance
  
  Volume: Volume 14 Pages: 5079-5087
- DOI
  10.2147/idr.s338165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08564
[Journal Article] Degradation Products of Complex Arabinoxylans by Bacteroides intestinalis Enhance the Host Immune Response2021
- Author(s)
  Yasuma Taro、Toda Masaaki、Abdel-Hamid Ahmed M.、D’Alessandro-Gabazza Corina、Kobayashi Tetsu、Nishihama Kota、D’Alessandro Valeria Fridman、Pereira Gabriel V.、Mackie Roderick I.、Gabazza Esteban C.、Cann Isaac
- Journal Title
  
  Microorganisms
  
  Volume: 9 Issue: 6 Pages: 1126-1126
- DOI
  10.3390/microorganisms9061126
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08203
[Journal Article] Too Premature to Deny the Potential of Thrombomodulin-alfa in Idiopathic Pulmonary Fibrosis2020
- Author(s)
  Kobayashi Tetsu、Hataji Osamu、Fujimoto Hajime、D'Alessandro-Gabazza Corina、Yasuma Taro、Gabazza Esteban C
- Journal Title
  
  American Journal of Respiratory and Critical Care Medicine
  
  Volume: - Issue: 11 Pages: 1449-1450
- DOI
  10.1164/rccm.202002-0271le
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17960, KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-20K08564, KAKENHI-PROJECT-18K08175
[Journal Article] Low-Dose of Intrapulmonary Pirfenidone Improves Human Transforming Growth Factorβ1-Driven Lung Fibrosis2020
- Author(s)
  Okano Tomohito、Kobayashi Tetsu、Yasuma Taro、D’Alessandro-Gabazza Corina N.、Toda Masaaki、Fujimoto Hajime、Nakahara Hiroki、Okano Yuko、Takeshita Atsuro、Nishihama Kota、Saiki Haruko、Tomaru Atsushi、Fridman D’Alessandro Valeria、Ishida Satoru、Sugimoto Hiromi、Takei Yoshiyuki、Gabazza Esteban C.
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 11
- DOI
  10.3389/fphar.2020.593620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08564, KAKENHI-PROJECT-18K08175
[Journal Article] De Novo T790M Mutation in an L858R Epidermal Growth Factor Receptor Mutant-Associated Lung Adenocarcinoma2020
- Author(s)
  Fujiwara Takumi、Kobayashi Tetsu、Yasuma Taro、D’Alessandro-Gabazza Corina N.、Toda Masaaki、Fujimoto Hajime、Fujiwara Kentaro、Takeshita Atsuro、Nishihama Kota、Okano Tomohito、D’Alessandro Valeria Fridman、Takei Yoshiyuki、Hataji Osamu、Gabazza Esteban C
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 10 Pages: 3074-3074
- DOI
  10.3390/cancers12103074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08175
[Journal Article] Factors leading to failure to diagnose pulmonary malignant tumors using endobronchial ultrasound with guide sheath within the target lesion.2019
- Author(s)
  Nishii Y, Yasuma T, Ito K, Suzuki Y, Watanabe F, Kobayashi T, Nishihama K,　D'Alessandro-Gabazza CN, Fujimoto H, Gabazza EC, Asano F, Taguchi O, Hataji O.
- Journal Title
  
  Respir Res.
  
  Volume: 20 Issue: 1 Pages: 207-207
- DOI
  10.1186/s12931-019-1178-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08175, KAKENHI-PROJECT-19K17738, KAKENHI-PROJECT-19K17960, KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-17K09611
[Journal Article] Protein S is Protective in Acute Lung Injury by Inhibiting Cell Apoptosis2019
- Author(s)
  Baffour Tonto Prince、Yasuma Taro、Kobayashi Tetsu、D’Alessandro-Gabazza Corina、Toda Masaaki、Saiki Haruko、Fujimoto Hajime、Asayama Kentaro、Fujiwara Kentaro、Nishihama Kota、Okano Tomohito、Takeshita Atsuro、Gabazza Esteban
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 5 Pages: 1082-1082
- DOI
  10.3390/ijms20051082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-17K09611
[Journal Article] Protective Role of Matrix Metalloproteinase-2 in Allergic Bronchial Asthma.2019
- Author(s)
  Takahashi Y, Kobayashi T, D'Alessandro-Gabazza CN, Toda M, Fujiwara K, Okano T, Fujimoto H, Asayama K, Takeshita A, Yasuma T, Nishihama K, Inoue R, Qin L,Takei Y, Taguchi O, Gabazza EC.
- Journal Title
  
  Front Immunol.
  
  Volume: 10 Pages: 1795-1795
- DOI
  10.3389/fimmu.2019.01795
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08175, KAKENHI-PROJECT-19K17738, KAKENHI-PROJECT-19K17960, KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-17K09611
[Journal Article] Protein S is Protective in Acute Lung Injury by Inhibiting Cell Apoptosis.2019
- Author(s)
  Baffour Tonto P, Yasuma T, Kobayashi T, D'Alessandro-Gabazza CN, Toda M, Saiki H, Fujimoto H, Asayama K, Fujiwara K, Nishihama K, Okano T, Takeshita A, Gabazza EC.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20 Pages: 1082-1082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08175
[Journal Article] Risks of Treating Idiopathic Pulmonary Fibrosis with a TAM Receptor Kinase Inhibitor2018
- Author(s)
  D’Alessandro-Gabazza Corina N.、Kobayashi Tetsu、Gabazza Esteban C.
- Journal Title
  
  American Journal of Respiratory and Critical Care Medicine
  
  Volume: 198 Issue: 7 Pages: 970-971
- DOI
  10.1164/rccm.201805-0871le
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08175, KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-17K09611
[Journal Article] Mice overexpressing latent matrix metalloproteinase-2 develop lung emphysema after short-term exposure to cigarette smoke extract2018
- Author(s)
  Onishi Masahiro、Kobayashi Tetsu、D'Alessandro-Gabazza Corina N.、Fujimoto Hajime、Chelakkot-Govindalayathil Ayshwarya-Lakshmi、Takahashi Yoshinori、Yasuma Taro、Nishihama Kota、Toda Masaaki、Takei Yoshiyuki、Taguchi Osamu、Gabazza Esteban C.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 497 Issue: 1 Pages: 332-338
- DOI
  10.1016/j.bbrc.2018.02.081
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-17K09611, KAKENHI-PROJECT-15K09170
[Journal Article] Renal Injury during Long-Term Crizotinib Therapy2018
- Author(s)
  Yasuma Taro、Kobayashi Tetsu、D’Alessandro-Gabazza Corina、Fujimoto Hajime、Ito Kentaro、Nishii Yoichi、Nishihama Kota、Baffour Tonto Prince、Takeshita Atsuro、Toda Masaaki、Gabazza Esteban、Taguchi Osamu、Yonemura Shigenori、Hataji Osamu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 10 Pages: 2902-2902
- DOI
  10.3390/ijms19102902
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-17K09611
[Journal Article] Identification of Halophilic Microbes in Lung Fibrotic Tissue by Oligotyping2018
- Author(s)
  D’Alessandro-Gabazza Corina N.、Méndez-García Celia、Hataji Osamu、Westergaard Sara、Watanabe Fumiaki、Yasuma Taro、Toda Masaaki、Fujimoto Hajime、Nishihama Kota、Fujiwara Kentaro、Taguchi Osamu、Kobayashi Tetsu、Mackie Roderick I.、Cann Isaac、Gabazza Esteban C.
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 9 Pages: 1892-1892
- DOI
  10.3389/fmicb.2018.01892
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08175, KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-17K09611
[Journal Article] A Retrospective Comparison of the Clinical Efficacy of Gefitinib, Erlotinib and Afatinib in Japanese Patients with Non-small Cell Lung Cancer2018
- Author(s)
  Fujiwara A, Yoshida M, Fujimoto H, Nakahara H, Ito K, Nishihama K, Yasuma T, Hataji O, Taguchi O, D'Alessandro-Gabazza CN, Gabazza EC, Kobayashi T
- Journal Title
  
  Oncol Res
  
  Volume: 印刷中 Issue: 7 Pages: 1031-1036
- DOI
  10.3727/096504018x15151523767752
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-17K09611, KAKENHI-PROJECT-15K09170
[Journal Article] Comparable immunoreactivity rates of PD-L1 in archival and recent specimens from non-small cell lung cancer2018
- Author(s)
  Nakamura Yuki、Kobayashi Tetsu、Nishii Yoichi、Suzuki Yuta、Saiki Haruko、Ito Kentaro、Watanabe Fumiaki、Nishihama Kota、Yasuma Taro、D'Alessandro-Gabazza Corina N.、Katsuta Koji、Fujimoto Hajime、Gabazza Esteban C、Taguchi Osamu、Hataji Osamu
- Journal Title
  
  Thoracic Cancer
  
  Volume: 9 Issue: 11 Pages: 1476-1482
- DOI
  10.1111/1759-7714.12861
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-17K09611
[Journal Article] Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling2018
- Author(s)
  Kuwabara Yu、Kobayashi Tetsu、D'Alessandro-Gabazza Corina N.、Toda Masaaki、Yasuma Taro、Nishihama Kota、Takeshita Atsuro、Fujimoto Hajime、Nagao Mizuho、Fujisawa Takao、Gabazza Esteban C.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9
- DOI
  10.3389/fimmu.2018.02163
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08175
[Journal Article] Inhibition of Cell Apoptosis and Amelioration of Pulmonary Fibrosis by Thrombomodulin2017
- Author(s)
  Fujiwara Kentaro、Kobayashi Tetsu、Fujimoto Hajime、Nakahara Hiroki、D'Alessandro-Gabazza Corina N.、Hinneh Josephine A.、Takahashi Yoshinori、Yasuma Taro、Nishihama Kota、Toda Masaaki、Kajiki Masahiro、Takei Yoshiyuki、Taguchi Osamu、Gabazza Esteban C.
- Journal Title
  
  Am J Pathol
  
  Volume: 187 Issue: 10 Pages: 2312-2322
- DOI
  10.1016/j.ajpath.2017.06.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-17K09611, KAKENHI-PROJECT-15K09170
[Journal Article] Smart watch-based coaching with tiotropium and olodaterol ameliorates physical activity in patients with chronic obstructive pulmonary disease2017
- Author(s)
  Hataji O, Nishii Y, Ito K, Sakaguchi T, Saiki H, Suzuki Y, D'Alessandro-Gabazza C, Fujimoto H, Kobayashi T, Gabazza EC, Taguchi O
- Journal Title
  
  Exp Ther Med
  
  Volume: 14 Pages: 4061-4064
- DOI
  10.3892/etm.2017.5088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-17K09611, KAKENHI-PROJECT-15K09170
[Journal Article] Oligonucleotide-targeting periostin ameliorates pulmonary fibrosis2017
- Author(s)
  Tomaru A、Kobayashi T、Hinneh J A、Baffour Tonto P、D'Alessandro-Gabazza C N、Fujimoto H、Fujiwara K、Takahashi Y、Ohnishi M、Yasuma T、Nishihama K、Yoshino M、Takao K、Toda M、Totoki T、Takei Y、Yoshikawa K、Taguchi O、Gabazza E C
- Journal Title
  
  Gene Ther
  
  Volume: 24 Issue: 11 Pages: 706-716
- DOI
  10.1038/gt.2017.80
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-17K09611, KAKENHI-PROJECT-15K09170
[Journal Article] Efficacy of osimertinib in a patient with non-small cell lung cancer harboring epithelial growth factor receptor exon 19 deletion/T790M mutation, with poor performance status2017
- Author(s)
  Nishii Yoichi、Hataji Osamu、Ito Kentaro、Watanabe Fumiaki、Kobayashi Tetsu、D'alessandro-Gabazza Corina、Toda Masaaki、Taguchi Osamu、Yamamoto Nobuyuki、Gabazza Esteban
- Journal Title
  
  Mol Clin Oncol
  
  Volume: 8 Pages: 246-249
- DOI
  10.3892/mco.2017.1522
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08442, KAKENHI-PROJECT-17K09611, KAKENHI-PROJECT-15K09170
[Journal Article] irculating fibrocytes correlate with the asthma control test score.2016
- Author(s)
  Kobayashi H, Naito M, Masuya M, Maruyama M, Urata K, Takahashi Y, Tomaru A,Fujiwara K, Ohnishi M, Takagi T, Kobayashi T,D'Alessandro-Gabazza C, Urawa M,Gabazza EC, Taguchi O, Takei Y.
- Journal Title
  
  Allergol Immunopathol (Madr).
  
  Volume: 44 Issue: 3 Pages: 152-154
- DOI
  10.1016/j.aller.2015.09.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461189, KAKENHI-PROJECT-26860605, KAKENHI-PROJECT-15K09170, KAKENHI-PROJECT-16K09307
[Journal Article] Thrombomodulin inhibits the activation of eosinophils and mast cells.2015
- Author(s)
  Roeen Z, Toda M, D'Alessandro-Gabazza CN, Onishi M, Kobayashi T, Yasuma T, Urawa M, Taguchi O, Gabazza EC.
- Journal Title
  
  Cell Immunol.
  
  Volume: 293 Issue: 1 Pages: 34-40
- DOI
  10.1016/j.cellimm.2014.11.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461154, KAKENHI-PROJECT-15K09170, KAKENHI-PROJECT-25461189
[Journal Article] Activated protein C modulates the proinflammatory activity of dendritic cells.2015
- Author(s)
  Matsumoto T, Matsushima Y, Toda M, Roeen Z, D'Alessandro-Gabazza CN, Hinneh JA, Harada E, Yasuma T, Yano Y, Urawa M, Kobayashi T, Taguchi O, Gabazza EC.
- Journal Title
  
  J Asthma Allergy
  
  Volume: 8 Pages: 29-37
- DOI
  10.2147/jaa.s75261
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09170, KAKENHI-PROJECT-25461154, KAKENHI-PROJECT-25461189
[Journal Article] Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels.2014
- Author(s)
  Kobayashi T, Kim H, Liu X, Sugiura H, Kohyama T, Fang Q, Wen FQ, Abe S, Wang X, Atkinson JJ, Shipley JM, Senior RM, Rennard SI.
- Journal Title
  
  Am J　Physiol Lung Cell Mol Physiol.
  
  Volume: 306(11) Issue: 11 Pages: 1006-1015
- DOI
  10.1152/ajplung.00015.2014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461189
[Journal Article] Thrombin-activatable fibrinolysis inhibitor protects against acute lung injury by inhibiting the complement system.2013
- Author(s)
  Naito M, Taguchi O, Kobayashi T, Takagi T, D'Alessandro-Gabazza CN, Matsushima Y, Boveda-Ruiz D, Gil-Bernabe P, Matsumoto T, Chelakkot-Govindalayathil AL, Toda M, Yasukawa A, Hataji O, Morser J, Takei Y, Gabazza EC.
- Journal Title
  
  Am J Respir Cell Mol Biol.
  
  Volume: 49 Issue: 4 Pages: 646-653
- DOI
  10.1165/rcmb.2012-0454oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591128, KAKENHI-PROJECT-25461154, KAKENHI-PROJECT-25461189
[Journal Article] Dose-dependent differential effects of thrombin in allergic bronchial asthma.2013
- Author(s)
  Miyake Y, D'Alessandro-Gabazza CN, Takagi T, Naito M, Hataji O, Nakahara H, Yuda H, Fujimoto H, Kobayashi H, Yasuma T, Toda M, Kobayashi T, Yano Y, Morser J, Taguchi O, Gabazza EC.
- Journal Title
  
  J Thromb Haemost.
  
  Volume: 11 Issue: 10 Pages: 1903-1915
- DOI
  10.1111/jth.12392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591128, KAKENHI-PROJECT-25461154
[Journal Article] Eosinophils promote epithelial to mesenchymal transition of bronchial epithelial cells.2013
- Author(s)
  Yasukawa A, Hosoki K, Toda M, Miyake Y, Matsushima Y, Matsumoto T, Boveda-Ruiz D, Gil-Bernabe P, Nagao M, Sugimoto M, Hiraguchi Y, Tokuda R, Naito M, Takagi T, D'Alessandro-Gabazza CN, Suga S, Kobayashi T, Fujisawa T, Taguchi O, Gabazza EC.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 5 Pages: 1-12
- DOI
  10.1371/journal.pone.0064281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591471, KAKENHI-PROJECT-24591128, KAKENHI-PROJECT-25461154
[Journal Article] Differential role of regulatory T cells in early and late stages of pulmonary fibrosis.2013
- Author(s)
  Boveda-Ruiz D, D'Alessandro-Gabazza CN, Toda M, Takagi T, Naito M, Matsushima Y, Matsumoto T, Kobayashi T, Gil-Bernabe P, Chelakkot-Govindalayathil AL, Miyake Y, Yasukawa A, Morser J, Taguchi O, Gabazza EC.
- Journal Title
  
  Immunobiology.
  
  Volume: 218 Issue: 2 Pages: 245-254
- DOI
  10.1016/j.imbio.2012.05.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591128, KAKENHI-PROJECT-25461154
[Journal Article] Development and preclinical efficacy of novel transforming growth factor-β1 short interfering RNAs for pulmonary fibrosis2012
- Author(s)
  D' Alessandro-Gabazza CN, Kobayashi T, Boveda-Ruiz D, Takagi T, Toda M, Gil-Bernabe P, Miyake Y, Yasukawa A, Matsuda Y, Suzuki N, Saito H, Yano Y, Fukuda A, Hasegawa T, Toyobuku H, Rennard SI, Wagner PD, Morser J, Takei Y, Taguchi O, Gabazza EC
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 46 Pages: 397-406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590133
[Journal Article] Role of thrombin-activatablefibrinolysis inhibitor in allergic bronchial asthma2012
- Author(s)
  Fujiwara A, Taguchi O, Takagi T, D'Alessandro-Gabazza CN, Boveda-Ruiz D, Toda M, Yasukawa A, Matsushima Y, Miyake Y, Kobayashi H, Kobayashi T, Gil-Bernabe P,Naito M, Yoshida M, Morser J, Takei Y, Gabazza EC.
- Journal Title
  
  Lung
  
  Volume: 190 Pages: 189-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590859
[Journal Article] Role of thrombin-activatable fibrinolysis inhibitor in allergic bronchial asthma2012
- Author(s)
  Fujiwara A, Taguchi O, Takagi T, D' Alessandro-Gabazza CN, Boveda-Ruiz D, Toda M, Yasukawa A, Matsushima Y, Miyake Y, Kobayashi H, Kobayashi T, Gil-Bernabe P, Naito M, Yoshida M, Morser J, Takei Y, Gabazza EC
- Journal Title
  
  Lung
  
  Volume: 190 Pages: 189-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590133
[Journal Article] 呼吸器疾患に対するsiRNA創薬の進歩2012
- Author(s)
  小林哲
- Journal Title
  
  分子呼吸器病
  
  Volume: 16 Pages: 91-93
- Data Source
  KAKENHI-PROJECT-22590859
[Journal Article] Development and preclinical efficacy of novel transforming growthfactor-β1 short interfering RNAs for pulmonary fibrosis2012
- Author(s)
  D'Alessandro-Gabazza CN, Kobayashi T, Boveda-Ruiz D, Takagi T, Toda M,Gil-Bernabe P, Miyake Y, Yasukawa A, Matsuda Y, Suzuki N, Saito H, Yano Y, Fukuda A, Hasegawa T, Toyobuku H, Rennard SI, Wagner PD, Morser J, Takei Y, Taguchi O, Gabazza EC
- Journal Title
  
  Am J Respir Cell MolBiol
  
  Volume: 46 Pages: 397-406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590859
[Journal Article] Correlation between circulating fibrocytes, and activity andprogression of interstitial lung diseases2012
- Author(s)
  Fujiwara A, Kobayashi H, Masuya M, Maruyama M, Nakamura S, Ibata H, FujimotoH, Ohnishi M, Urawa M, Naito M, Takagi T, Kobayashi T, Gabazza EC, Takei Y,Taguchi O
- Journal Title
  
  Respirology
  
  Volume: 17 Issue: 4 Pages: 693-8
- DOI
  10.1111/j.1440-1843.2012.02167.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590859
[Journal Article] Correlation between circulating fibrocytes and activity and progression of interstitial lung diseases2012
- Author(s)
  Fujiwara A, Kobayashi H, Masuya M, Maruyama M, Nakamura S, Ibata H, Fujimoto H, Ohnishi M, Urawa M, Naito M, Takagi T, Kobayashi T, Gabazza EC, Takei Y, Taguchi O
- Journal Title
  
  Respirology
  
  Volume: (in press)(掲載決定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590133
[Journal Article] Efficacy of a novel class of RNA interference therapeutic agents2012
- Author(s)
  Hamasaki T, Suzuki H, Shirohzu H, Matsumoto T, D'Alessandro-Gabazza CN,Gil-Bernabe P, Boveda-Ruiz D, Naito M, Kobayashi T, Toda M, Mizutani T, TaguchiO, Morser J, Eguchi Y, Kuroda M, Ochiya T, Hayashi H, Gabazza EC, Ohgi T
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 8 Pages: 1-15
- DOI
  10.1371/journal.pone.0042655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590859, KAKENHI-PROJECT-23390087, KAKENHI-PROJECT-23659192, KAKENHI-PROJECT-23659626, KAKENHI-PROJECT-24591128
[Journal Article] Inhibition ofallergic bronchial asthma by thrombomodulin is mediated by dendritic cells2011
- Author(s)
  Takagi T, Taguchi O, Toda M, Ruiz DB, Bernabe PG, D' Alessandro-Gabazza CN, Miyake Y, Kobayashi T, Aoki S, Chiba F, Yano Y, Conway EM, Munesue S, Yamamoto Y, Yamamoto H, Suzuki K, Takei Y, Morser J, Gabazza EC
- Journal Title
  
  Am J Respir Crit Care Med
  
  Volume: 183 Pages: 31-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590133
[Journal Article] Solitary pulmonary nodule of benign metastasizing leiomyoma associated with primary lung cancer : a case report2011
- Author(s)
  Naito M, Kobayashi T, Yoshida M, Fujiwara K, Onishi M, Fujiwara A, Takagi T, Kobayashi H, Gabazza EC, Takei Y, Taguchi O
- Journal Title
  
  J Med Case Reports
  
  Volume: 5 Pages: 500-500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590133
[Journal Article] Inhibition of allergicbronchial asthma by thrombomodulin is mediated by dendritic cells2011
- Author(s)
  Takagi T, Taguchi O, Toda M, Ruiz DB, Bernabe PG, D'Alessandro-Gabazza CN,Miyake Y, Kobayashi T, Aoki S, Chiba F, Yano Y, Conway EM, Munesue S, Yamamoto Y,Yamamoto H, Suzuki K, Takei Y, Morser J, Gabazza EC
- Journal Title
  
  Am J RespirCrit Care Med
  
  Volume: 183 Pages: 31-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590859
[Journal Article] Efficacy of 23-valent pneumococcal vaccine in preventing pneumonia and improving survival in nursing home residents : double blind, randomised and placebo controlled trial2010
- Author(s)
  Maruyama T, Taguchi O, Niederman MS, Morser J, Kobayashi H, Kobayashi T, D' Alessandro-Gabazza C, Nakayama S, Nishikubo K, Noguchi T, Takei Y, Gabazza EC
- Journal Title
  
  BMJ
  
  Volume: 340 Pages: 1004-1004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590133
[Journal Article] Development and Preclinical Efficacy of Novel Transforming Growth Factor-β1 siRNAs for Pulmonary Fibrosis2010
- Author(s)
  Corina N D'Alessandro-Gabazza
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: (掲載確定) Issue: 3 Pages: 397-406
- DOI
  10.1165/rcmb.2011-0158oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590133, KAKENHI-PROJECT-22590859
[Journal Article] Hepatic growth factor (HGF) inhibits cigarette smoke extract induced apoptosis in human bronchial epithelial cells.2010
- Author(s)
  Togo S, Sugiura H, Nelson A, Kobayashi T, et al.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 316 Pages: 3501-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590859
[Journal Article] Presence of thrombin-activatable fibrinolysis inhibitor in Helicobacter pylori-associated gastro-duodenal disease2009
- Author(s)
  Ikeda A, Gabazza EC, Morser J, Imoto I, Kuroda M, D' Alessandro-Gabazza CN, Hara K, Ruiz DB, Bernabe PG, Katsurahara M, Toda M, Kobayashi Y, Yano Y, Sumida Y, Suzuki K, Taguchi O, Takei Y
- Journal Title
  
  Helicobacter
  
  Volume: 14 Pages: 147-155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590133
[Journal Article] The coagulation and protein C pathways in patients with sleep apnea2009
- Author(s)
  Takagi T, Morser J, Gabazza EC, Qin L, Fujiwara A, Naito M, Yamaguchi A, Kobayashi T, D' Alessandro-Gabazza CN, Boveda Ruiz D, Gil Bernabe P, Iwasaki Y, Takei Y, Taguchi O
- Journal Title
  
  Lung
  
  Volume: 187 Pages: 209-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590133
[Journal Article] Sphingosine 1-phosphate potentiateshuman lung fibroblast chemotaxis throughthe S1P2 receptor2008
- Author(s)
  Hashimoto M, Wang X, Mao L,Kobayashi T, Kawasaki S, Mori N, ToewsML, Kim HJ, Cerutis DR, Liu X, Rennard SI.
- Journal Title
  
  Am J Respir Cell Mol Biol 39(3)
  
  Pages: 356-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590893
[Journal Article] Roleof thrombin in interleukin-5 expressionfrom basophils2008
- Author(s)
  Yamaguchi A, Gabazza EC, Takei Y,Yano Y, Fujimoto H, D'Alessandro-GabazzaCN, Murakami E, Kobayashi T, Takagi T,Maruyama J, Suzuki K, Taguchi O.
- Journal Title
  
  Biochem Biophys ResCommun 28 ; 368(1)
  
  Pages: 116-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590893
[Journal Article] PKC delta mediates thromb in-augmented fibroblast-mediated collagen gel contraction.2008
- Author(s)
  Fang Q, Mao L, Kobayashi T, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 369
  
  Pages: 1199-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590893
[Journal Article] NF-kappaBmediates the survival of human bronchialepithelial cells exposed to cigarettesmoke extract2008
- Author(s)
  Liu X, Togo S, Al-Mugotir M, Kim H,Fang Q, Kobayashi T, Wang X, Mao L,Bitterman P, Rennard S.
- Journal Title
  
  Respir Res 23;9
  
  Pages: 66-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590893
[Journal Article] PKCdelta mediates thrombin-augmentedfibroblast-mediated collagen gelcontraction2008
- Author(s)
  Fang Q, Mao L, Kobayashi T, Wang X,Wyatt TA, Kim H, Liu X, Rennard SI
- Journal Title
  
  Biochem Biophys Res Commun 16;369(4)
  
  Pages: 1199-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590893
[Journal Article] A prospective comparison of nursinghome-acquired pneumonia withhospital-acquired pneumonia innon-intubated elderly2008
- Author(s)
  Maruyama T, Niederman MS,Kobayashi T, Kobayashi H, Takagi T,D'Alessandro-Gabazza CN, Fujimoto H, GilBernabe P, Hirohata S, Nakayama S,Nishikubo K, Yuda H, Yamaguchi A,Gabazza EC, Noguchi T, Takei Y, Taguchi O.
- Journal Title
  
  Respir Med 102(9)
  
  Pages: 1287-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590893
[Journal Article] RennardSI. Prostacyclin analogs stimulate VEGFproduction from human lung fibroblasts inculture2008
- Author(s)
  Kamio K, Sato T, Liu X, Sugiura H, TogoS, Kobayashi T, Kawasaki S, Wang X, MaoL, Ahn Y, Holz O, Magnussen H.
- Journal Title
  
  Am J Physiol Lung Cell MolPhysiol 294(6)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590893
[Journal Article] Prostacycl in analogs stimulate VEGF production from human lung fibroblast in culture.2008
- Author(s)
  Kamio K, Sato T, Liu X, Sugiura H, Togo S, Kobayashi T, et al.
- Journal Title
  
  Am J Physiol lung Cell Mol Physiol. 294
  
  Pages: 1226-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590893
[Journal Article] Role of the coagulation system in allergicinflammation in the upper airways2008
- Author(s)
  Shimizu S, Shimizu T, Morser J,Kobayashi T, Yamaguchi A, Qin L, Toda M,D'Alessandro-Gabazza C, Maruyama T,Takagi T, Yano Y, Sumida Y, Hayashi T,Takei Y, Taguchi O, Suzuki K, Gabazza EC.
- Journal Title
  
  Clin Immunol 129(2)
  
  Pages: 365-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590893
[Journal Article] Prostacyclin analogs inhibit fibroblastcontraction of collagen gels through thecAMP-PKA pathway2007
- Author(s)
  Kamio K, Liu X, Sugiura H, Togo S,Kobayashi T, Kawasaki S, Wang X, Mao L,AhnY, Hogaboam C, Toews ML, RennardSI
- Journal Title
  
  Am J Respir Cell Mol Biol 37(1)
  
  Pages: 113-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590893
[Journal Article] Prostaglandin E2 protects human lung fibroblasts from cigarette smoke Extractinduced apoptosis via EP2 receptor activation2007
- Author(s)
  Sugiura H, Liu X. Togo S, Kobayashi T, et. al.
- Journal Title
  
  J Cell Physiol. 210
  
  Pages: 99-110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590893
[Journal Article] The CCchemokine ligand 2 (CCL2) mediatesfibroblast survival through IL-62007
- Author(s)
  Liu X, Das AM, Seideman J, Griswold D,Afuh CN, Kobayashi T, Abe S, Fang Q, Hashimoto M, Kim H, Wang X, Shen L,Kawasaki S, Rennard SI
- Journal Title
  
  Am J Respir Cell Mol Biol 37(1)
  
  Pages: 121-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590893
[Journal Article] Prostacyclin analogs inhibit fibroblast contraction of collagen gels Through the cAMP-PKA pathway2007
- Author(s)
  Kamio K, Liu X, Sugiura H, TogoS, Kobayashi T, et.al.
- Journal Title
  
  Am J Respir Cell Mol Biol. 37
  
  Pages: 113-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590893
[Patent] ヒトMMP2を発現するトランスジェニック非ヒト哺乳類動物2013
- Inventor(s)
  ガバザエステバン, 田口修, 小林　哲
- Industrial Property Rights Holder
  三重大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-12-01
- Data Source
  KAKENHI-PROJECT-24591128
[Patent] ヒトTGFβ1を発現するトランスジェニックマウス2011
- Inventor(s)
  小林哲、Gabazza Esteban
- Industrial Property Rights Holder
  小林哲、Gabazza Esteban
- Industrial Property Number
  2011-237166
- Filing Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-21590133
[Patent] 線維症予防又は治療剤2010
- Inventor(s)
  小林哲, ガパザエステバン, 他
- Industrial Property Rights Holder
  三重大学大塚製薬
- Industrial Property Number
  2010-231946
- Filing Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-22590859
[Patent] 線維症予防又は治療剤2010
- Inventor(s)
  小林哲, ガバザエステバン
- Industrial Property Rights Holder
  三重大学大塚製薬
- Industrial Property Number
  2010-231946
- Filing Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-22590859
[Presentation] 細菌叢由来のアポトーシス促進ペプチドの抑制は急性肺障害を改善する2023
- Author(s)
  岡野智仁、岩中宗一、伊藤稔之、古橋一樹、大岩綾香、鶴賀龍樹、齋木晴子、藤原拓海、都丸敦史、高橋佳紀、藤本源、Valeria Fridman D'Alessandro、Corina N. D'Alessandro-Gabazza、Gabazza Esteban C、小林哲
- Organizer
  第63回呼吸器学会
- Data Source
  KAKENHI-PROJECT-21K08203
[Presentation] 肺内細菌叢由来ペプチドの炎症促進作用2023
- Author(s)
  古橋一樹、小林哲、伊藤稔之、大岩綾香、鶴賀龍樹、岡野智仁、藤原拓海、都丸敦史、高橋佳紀、藤本源、Corina Gabazza、Esteban C. Gabazza
- Organizer
  第63回呼吸器学会
- Data Source
  KAKENHI-PROJECT-21K08203
[Presentation] Corisinは肺線維症のバイオマーカーとなりうる2023
- Author(s)
  伊藤稔之、小林哲、大岩綾香、古橋一樹、鶴賀龍樹、岡野智仁、藤原拓海、都丸敦史、高橋佳紀、藤本源、Corina Gabazza、Esteban C. Gabazza
- Organizer
  第63回呼吸器学会
- Data Source
  KAKENHI-PROJECT-21K08203
[Presentation] 肺線維症モデルマウスにおける肺内細菌叢の検討2022
- Author(s)
  藤本　源、小林　哲、ガバザ　エステバン
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-20K08564
[Presentation] 肺線維症モデルマウスにおける肺内細菌叢の検討2022
- Author(s)
  藤本　源、小林　哲、ガバザ　エステバン
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-22K08280
[Presentation] ブドウ球菌由来のアポトーシス促進ペプチドはブレオマイシン誘発肺線維症モデルにおいて慢性期の肺線維化を促進する2022
- Author(s)
  岡野　智仁、Valeria Fridman D’Alessandro、古橋　一樹、大岩　綾香、鶴賀　龍樹、齋木　晴子、藤原　拓海、浅山　健太郎、高橋　佳紀、都丸　敦史、中原　博紀、藤本　源、岡野　優子、竹下　敦郎、安間　太郎、Corina N. D’Alessandro-Gabazza、Esteban C. Gabazza、小林　哲
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08564
[Presentation] ブドウ球菌由来のアポトーシス促進ペプチドはブレオマイシン誘発肺線維症モデルにおいて慢性期の肺線維化を促進する2022
- Author(s)
  岡野智仁,VF DAlessandro、古橋一樹、大岩綾香、鶴賀龍樹、齊木晴子、藤原拓海、浅山健太郎、高橋佳紀、都丸敦史、中原博紀、藤本源、岡野優子、竹下敦郎、安間太郎、CND Gabazza、Esteban C. Gabazza、小林哲
- Organizer
  第６２回呼吸器学会
- Data Source
  KAKENHI-PROJECT-21K08203
[Presentation] 微生物叢由来ペプチドの異なる細胞株に対するアポトーシス誘導の検討2022
- Author(s)
  齋木　晴子、小林　哲、鶴賀　龍樹、藤原　拓海、浅山　健太郎、岡野　智仁、都丸　敦史、高橋　佳紀、中原　博紀、藤本　源、Corina N. D’Alessandro-Gabazza、Esteban C. Gabazza
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K08280
[Presentation] ブレオマイシン肺線維症マウスモデルにおける肺内細菌叢由来の細胞死因子の経時的変化の検討2022
- Author(s)
  都丸敦史、齊木晴子、鶴賀龍樹、藤原拓海、岡野智仁、浅山健太郎、高橋佳紀、中原博紀、藤本源、CND Gabazza、Esteban C. Gabazza、小林哲
- Organizer
  第６２回呼吸器学会
- Data Source
  KAKENHI-PROJECT-21K08203
[Presentation] ブドウ球菌由来のアポトーシス促進ペプチドはブレオマイシン誘発肺線維症モデルにおいて慢性期の肺線維化を促進する2022
- Author(s)
  岡野智仁、Valeria F.DAlessandro、古橋一樹、大岩綾香、鶴賀龍樹、齊木晴子、藤原拓海、浅山健太郎、高橋佳紀、都丸敦史、中原博紀、藤本源、岡野優子、竹下敦郎、安間太郎、CND Gabazza、Esteban C. Gabazza、小林哲
- Organizer
  第６２回呼吸器学会
- Data Source
  KAKENHI-PROJECT-21K08203
[Presentation] The Role of the Lung Microbiota in Acute Exacerbation of Pulmonary Fibrosis2022
- Author(s)
  Valeria Fridman D’Alessandro, Tomohito Okano, Haruko Saiki, Tatsuki Tsuruga, Kentaro Asayama, Atsushi Tomaru, Hiroki Nakahara, Hajime Fujimoto, Corina N. D’Alessandro-Gabazza, Esteban C. Gabazza, Tetsu Kobayashi
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K08280
[Presentation] ブレオマイシン肺線維症マウスモデルにおける肺内細菌叢由来の細胞死因子（コリシン）の経時的変動の検討2022
- Author(s)
  都丸　敦史、齋木　晴子、鶴賀　龍樹、藤原　拓海、岡野　智仁、浅山　健太郎、高橋　佳紀、中原　博紀、藤本　源、Corina N. D’Alessandro-Gabazza、Esteban C. Gabazza、小林　哲
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K08280
[Presentation] The Role of the Lung Microbiota in Acute Exacerbation of Pulmonary Fibrosis2022
- Author(s)
  Valeria Fridman D’Alessandro, Tomohito Okano, Haruko Saiki, Tatsuki Tsuruga, Kentaro Asayama, Atsushi Tomaru, Hiroki Nakahara, Hajime Fujimoto, Corina N. D’Alessandro-Gabazza, Esteban C. Gabazza, Tetsu Kobayashi
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08564
[Presentation] マトリックスメタロプロテアーゼ-2（MMP-2）の肺線維症への役割2022
- Author(s)
  鶴賀　龍樹、小林　哲、齋木　晴子、岡野　智仁、藤原　拓海、浅山　健太郎、都丸　敦史、高橋　佳紀、藤本　源、Corina N. D’Alessandro-Gabazza、Esteban C. Gabazza
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08564
[Presentation] MUC5Bのrs35705950単塩基多型過剰発現トランスジェニックマウスの作製2020
- Author(s)
  都丸　敦史、小林　哲、齊木　晴子、浅山　健太郎、岡野　智仁、藤原　拓海、高橋　佳紀、中原　博紀、藤本　源、ガバザ　エステバン
- Organizer
  第60回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08564
[Presentation] 抗甲状腺薬によるANCA関連間質性肺炎と考えられた1例2020
- Author(s)
  岡野　智仁、鶴賀　龍樹、齊木　晴子、藤原　拓海、浅山　健太郎、高橋　佳紀、都丸　敦史、中原　博紀、藤本　源、小林　哲、ガバザ　エステバン
- Organizer
  第117回日本呼吸器学会東海地方会
- Data Source
  KAKENHI-PROJECT-20K08564
[Presentation] The Role of Matrix Metalloproteinase-2 in Pulmonary Fibrosis2020
- Author(s)
  Tomohito Okano, Tetsu Kobayashi, Haruko Saiki, Takumi Fujiwara, Kentaro Asayama, Yoshinori Takahashi, Atsushi Tomaru, Hiroki Nakahara, Hajime Fujimoto, Corina N. D’Alessandro-Gabazza, Esteban C. Gabazza
- Organizer
  第60回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08564
[Presentation] TGF-Β1過剰発現マウスを用いた肺線維化と発癌に関する検討2020
- Author(s)
  中原　博紀、小林　哲、齊木　晴子、藤原　拓海、岡野　智仁、浅山　健太郎、都丸　敦史、高橋　佳紀、藤本　源、ガバザ　コリナ、ガバザ　エステバン
- Organizer
  第60回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08564
[Presentation] 呼吸器疾患とmicrobiome2018
- Author(s)
  小林哲
- Organizer
  日本呼吸器学会
- Data Source
  KAKENHI-PROJECT-18K08175
[Presentation] 当院におけるEGFR遺伝子変異陽性肺癌患者に対する免疫チェックポイント阻害薬の使用経験2018
- Author(s)
  岡野　智仁、樋口　友里恵、齋木　晴子、藤原　拓海、浅山　健太郎、都丸　敦史、高橋　佳紀、藤原　研太郎、中原　博紀、藤本　源、小林　哲、伊藤　健太郎、田口　修、ガバザ　エステバン
- Organizer
  第113回日本肺癌学会中部支部学術集会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] 発症後20年経過したALK融合遺伝子陽性肺癌の1例2018
- Author(s)
  樋口　友里恵、齋木　晴子、岡野　智仁、藤原　拓海、浅山　健太郎、都丸　敦史、高橋　佳紀、藤原　研太郎、中原　博紀、藤本　源、小林　哲、ガバザ　エステバン、田口　修
- Organizer
  第113回日本肺癌学会中部支部学術集会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] マウス肺線維化モデルに対するPeriostin抑制効果の検討2018
- Author(s)
  都丸　敦史、ガバザ　エステバン、樋口　友里恵、齋木　晴子、藤原　拓海、浅山　健太郎、岡野　智仁、高橋　佳紀、藤原　研太郎、中原　博紀、藤本　源、戸田　雅昭、ガバザ　コリナ、小林　哲
- Organizer
  第48回吸入療法研究会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] 間質性肺炎の病態形成・線維化における凝固線溶系の関わり2018
- Author(s)
  藤本　源、小林　哲、樋口　友里恵、齋木　晴子、藤原　拓海、岡野　智仁、浅山　健太郎、都丸　敦史、高橋　佳紀、藤原　研太郎、大西　真裕、中原　博紀、ガバザ　エステバン、田口　修
- Organizer
  第58回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] アレクチニブ投与後に高血糖高浸透圧症候群を来した肺腺癌の1例2018
- Author(s)
  藤本　源、浅山　健太郎、岡野　智仁、藤原　拓海、高橋　佳紀、都丸　敦史、藤原　研太郎、大西　真裕、中原　博紀、小林　哲、ガバザ　エステバン、田口　修
- Organizer
  第112回日本肺癌学会中部支部学術集会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] KL-6やフェリチンが低値であったにも関わらず急速に呼吸不全が進行したMDA5抗体陽性CADMの1例2018
- Author(s)
  樋口　友里恵、高橋　佳紀、藤本　源、齋木　晴子、岡野　智仁、藤原　拓海、浅山　健太郎、都丸　敦史、藤原　研太郎、中原　博紀、小林　哲、ガバザ　エステバン、田口　修
- Organizer
  第131回日本結核病学会東海地方大会　第113回日本呼吸器学会東海地方学会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] MMP-2はマクロファージをM1に分化誘導し気管支喘息に対して防御的に働く2018
- Author(s)
  藤本　源、小林　哲、樋口　友里恵、齋木　晴子、岡野　智仁、藤原　拓海、浅山　健太郎、高橋　佳紀、都丸　敦史、藤原　研太郎、中原　博紀、ガバザ　エステバン
- Organizer
  第67回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] 気管支喘息モデルにおけるヒトMatrix Metalloproteinase-2の効果2017
- Author(s)
  藤本　源、小林　哲、浅山　健太郎、高橋　佳紀、都丸　敦史、藤原　研太郎、大西　真裕、中原　博紀、Corina N. D’Alessandro-Gabazza、田口　修、Esteban Gabazza
- Organizer
  第57回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] 気管支喘息患者におけるマトリックスメタロプロテアーゼ2の変動2017
- Author(s)
  藤本　源、小林　哲、浅山　健太郎、都丸　敦史、高橋　佳紀、藤原　研太郎、大西　真裕、中原　博紀、西濵　康太、安間　太郎、ガバザ　コリナ、戸田　雅昭、ガバザ　エステバン、田口　修
- Organizer
  第66回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] Nintedanib服用中に整形外科的手術が予定された特発性肺線維症の1例2017
- Author(s)
  藤本　源、浅山　健太郎、高橋　佳紀、都丸　敦史、藤原　研太郎、大西　真裕、中原　博紀、小林　哲、田口　修、ガバザ　エステバン
- Organizer
  第129回日本結核病学会東海地方大会　第111回日本呼吸器学会東海地方学会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] 肺癌科学療法中に生じた脾摘患者のAeromonas caviae敗血症の1例2017
- Author(s)
  渡邉　さや、藤原　研太郎、藤原　拓海、浅山　健太郎、都丸　敦史、高橋　佳紀、大西　真裕、中原　博紀、中原　博紀、藤本　源、小林　哲、田口　修、ガバザ　エステバン
- Organizer
  第130回日本結核病学会東海地方大会　第112回日本呼吸器学会東海地方学会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] ヒト変異EGFR遺伝子全長を組み込んだ肺癌モデルマウスにおけるバイオマーカーの検討2017
- Author(s)
  高橋　佳紀、浅山　健太郎、都丸　敦史、藤原　研太郎、大西　真裕、中原　博紀、藤本　源、小林　哲、ガバザ　エステバン、田口　修
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] L858R変異EGFR導入マウスに発生した肺腺癌の組織パターンの特徴2017
- Author(s)
  藤原　研太郎、小林　哲、浅山　健太郎、都丸　敦史、高橋　佳紀、大西　真裕、中原　博紀、藤本　源、安間　太郎、ガバザ　コリナ、ガバザ　エステバン、田口　修
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] 肺NTM症の治療後にANCA関連血管炎を発症しステロイド治療中に肺アスペルギルス症を合併した1例2017
- Author(s)
  高橋　佳紀、浅山　健太郎、都丸　敦史、藤原　研太郎、大西　真裕、中原　博紀、藤本　源、小林　哲、ガバザ　エステバン、田口　修
- Organizer
  第130回日本結核病学会東海地方大会　第112回日本呼吸器学会東海地方学会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] COPD患者に対するLAMA/LABA合剤とスマートウォッチ併用による身体活動性向上の試み2017
- Author(s)
  畑地　治、西井　洋一、伊藤　健太郎、坂口　直、齋木　晴子、鈴木　勇太、ガバザ　エステバン、小林　哲、田口　修
- Organizer
  第57回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] 気管支喘息におけるmatrix metalloproteinase-2(MMP-2)の変動2017
- Author(s)
  藤原　研太郎、小林　哲、浅山　健太郎、都丸　敦史、高橋　佳紀、大西　真裕、中原　博紀、藤本　源、ダレッサンドロ　ガバザ　コリナ、戸田　雅昭、田口　修、ガバザ　エステバン
- Organizer
  第16回Kinki Hokuriku Airway disease Conference
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] MMP-2過剰発現マウスにおける短期タバコ煙によるemphysema誘発の検討2017
- Author(s)
  大西　真裕、浅山　健太郎、高橋　佳紀、都丸　敦史、藤原　研太郎、中原　博紀、藤本　源、Corina N. D’Alessandro-Gabazza、Esteban C. Gabazza、田口　修、小林　哲
- Organizer
  第57回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] 変異EGFR導入マウスにおける肺腺癌の組織パターンの検討2017
- Author(s)
  藤原　研太郎、小林　哲、浅山　健太郎、都丸　敦史、高橋　佳紀、大西　真裕、中原　博紀、藤本　源、安間　太郎、ガバザ　エステバン、田口　修
- Organizer
  第57回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] ブレオマイシン誘発肺線維症におけるプロテインSのアポトーシス抑制効果についての検討2017
- Author(s)
  中原　博紀、小林　哲、浅山　健太郎、都丸　敦史、高橋　佳紀、藤原　研太郎、大西　真裕、藤本　源、ガバザ　コリナ、ガバザ　エステバン、田口　修
- Organizer
  第57回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] 肺癌モデルマウスにおけるバイオマーカーの検討2017
- Author(s)
  高橋　佳紀、小林　哲、浅山　健太郎、都丸　敦史、藤原　研太郎、大西　真裕、中原　博紀、藤本　源、ガバザ　エステバン、田口　修
- Organizer
  第57回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] MMP-2過剰発現マウスにおけるタバコ煙抽出液吸入による肺の気腫化の検討2017
- Author(s)
  大西　真裕、小林　哲、浅山　健太郎、高橋　佳紀、都丸　敦史、藤原　研太郎、中原　博紀、藤本　源、田口　修、戸田　雅昭、ガバザ　コリナ、ガバザ　エステバン
- Organizer
  第91回閉塞性肺疾患研究会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] マトリックスメタロプロテアーゼ2遺伝子導入喘息マウスにおける気道病変の解析2017
- Author(s)
  藤原　研太郎、小林　哲、浅山　健太郎、都丸　敦史、高橋　佳紀、大西　真裕、中原　博紀、藤本　源、西濵　康太、安間　太郎、ガバザ　コリナ、戸田　雅昭、ガバザ　エステバン、田口　修
- Organizer
  第66回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] マウス肺線維症モデルにおいてthrombomodulinは防御的に働く2017
- Author(s)
  浅山　健太郎、小林　哲、高橋　佳紀、都丸　敦史、藤原　研太郎、大西　真裕、中原　博紀、藤本　源、Corina Gabazza、Esteban Gabazza、田口　修
- Organizer
  第57回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] 気道の線維化の先には発癌があるのか？2017
- Author(s)
  小林　哲、Esteban C. Gabazza、浦田　健太郎、高橋　佳紀、都丸　敦史、藤原　研太郎、大西　真裕、中原　博紀、藤本　源、Corina N. D’Alessandro-Gabazza、戸田　雅昭、田口　修
- Organizer
  第36回気道分泌研究会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] 多発脳転移に対してオシメルチニブが著功したT790M陽性肺腺癌の1例2017
- Author(s)
  藤本　源、藤原　拓海、浅山　健太郎、高橋　佳紀、都丸　敦史、藤原　研太郎、大西　真裕、中原　博紀、小林　哲、ガバザ　エステバン、田口　修
- Organizer
  第111回日本肺癌学会中部支部学術集会
- Data Source
  KAKENHI-PROJECT-17K09611
[Presentation] RNA新時代2015
- Author(s)
  小林　哲
- Organizer
  第１２回呼吸器バイオマーカー研究会
- Place of Presentation
  東京（大手町サンケイプラザ）
- Year and Date
  2015-11-28
- Invited
- Data Source
  KAKENHI-PROJECT-25461189
[Presentation] ＩＰＦに対するRNAi創薬の可能性2015
- Author(s)
  小林　哲
- Organizer
  日本呼吸器学会総会
- Place of Presentation
  東京（国際フォーラム）
- Year and Date
  2015-04-18
- Invited
- Data Source
  KAKENHI-PROJECT-25461189
[Presentation] 気道リモデリングとその制御方法の試み2015
- Author(s)
  小林　哲
- Organizer
  第四回神奈川気道炎症病態研究会
- Place of Presentation
  神奈川県横浜市（ベイシェラトンホテル）
- Year and Date
  2015-10-31
- Invited
- Data Source
  KAKENHI-PROJECT-25461189
[Presentation] 肺線維化マウスを用いた細菌叢の検討2014
- Author(s)
  小林哲
- Organizer
  第１７回間質性肺炎細胞分子病態研究会
- Place of Presentation
  東京、砂防会館別館
- Year and Date
  2014-08-23
- Data Source
  KAKENHI-PROJECT-25461189
[Presentation] マウス疾患モデルを用いた線維化マーカーの探索2014
- Author(s)
  小林　哲
- Organizer
  第１１回呼吸器バイオマーカー研究会
- Place of Presentation
  東京、都市センターホテル
- Year and Date
  2014-11-29
- Data Source
  KAKENHI-PROJECT-25461189
[Presentation] 気管支喘息における樹状細胞に対する活性化プロテインＣの役割2014
- Author(s)
  高木健裕、高橋佳紀、都丸敦史、藤原研太郎、大西真裕、小林哲、小林裕康、ガバザ・エステバン、田口　修
- Organizer
  第54回日本呼吸器学会
- Place of Presentation
  大阪　国際会議場
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-24591128
[Presentation] COPD治療における“可逆性”の可能性2014
- Author(s)
  小林　哲、高橋　佳紀、都丸　敦史、藤原　研太郎、大西　真裕、高木　健裕、小林　裕康、Corina N. D’Alessandro-Gabazza、戸田　雅昭、Esteban C. Gabazza、田口　修
- Organizer
  第88回閉塞性肺疾患研究会
- Place of Presentation
  東京　大手町サンケイプラザ
- Year and Date
  2014-07-19
- Data Source
  KAKENHI-PROJECT-24591128
[Presentation] 気道リモデリング制御方法としてのRNAi創薬の試み2012
- Author(s)
  小林哲
- Organizer
  臨床喘息研究会第20回学術講演会
- Place of Presentation
  金沢
- Year and Date
  2012-10-06
- Data Source
  KAKENHI-PROJECT-22590859
[Presentation] 気道リモデリングにおけるメカニカルストレスの関与の検討2012
- Author(s)
  小林哲
- Organizer
  第84回閉塞性肺疾患研究会
- Place of Presentation
  東京
- Year and Date
  2012-01-28
- Data Source
  KAKENHI-PROJECT-22590859
[Presentation] 呼吸器疾患におけるRNAiを用いた治療の可能性2012
- Author(s)
  小林哲
- Organizer
  第85回閉塞性肺疾患研究会
- Place of Presentation
  東京
- Year and Date
  2012-07-21
- Data Source
  KAKENHI-PROJECT-22590859
[Presentation] 気管支喘息患者におけるthrombomodulin陽性樹状細胞の役割について/Inverse correlation of thrombomodulin-positive dendritic cells with airflow limitation in patients with allergic bronchial asthma2011
- Author(s)
  高木健裕,田口修,内藤雅大,戸田雅昭,小林哲,三宅泰士, Boveda-Ruiz D, D' Alessandro-Gabazza, Morser J, Gabazza EC
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉幕張メッセ
- Data Source
  KAKENHI-PROJECT-21590133
[Presentation] 気道リモデリングにおけるECM contraction および degradationの検討2011
- Author(s)
  小林哲
- Organizer
  第19回学術講演会
- Place of Presentation
  大阪
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22590859
[Presentation] 気道リモデリングにおける新規創薬の試み2011
- Author(s)
  小林哲
- Organizer
  アレルギー気道上皮細胞研究会第15回学術大会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-22590859
[Presentation] Effect of thrombin inhalation in a murine model of bronchial asthma2011
- Author(s)
  Takagi T, Onishi M, Naito M, Fujiwara A, Kobayashi T, Kobayashi H, D' Alessandro-Gabazza CN, Gabazza EC, Taguchi O.
- Organizer
  European Respiratory Society International Congress
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-21590133
[Presentation] Nasal obstruction and bronchial asthma2011
- Author(s)
  Hiroyasu Kobayashi
- Organizer
  American Thoracic Society
- Place of Presentation
  Convention Center, Denver, Colorado
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-21590133
[Presentation] Role of the complement system in exacerbation of acute lung injury in Thrombin-Activatable fibrinolysis inhibitor-deficient mice2011
- Author(s)
  内藤雅大,田口修,高木健裕,戸田雅昭,小林哲,三宅泰士, Boveda-Ruiz D, D' Alessandro-Gabazza, C, Gabazza EC
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉幕張メッセ
- Data Source
  KAKENHI-PROJECT-21590133
[Presentation] Role of thrombin-activatable fibrinolysis inhibitor in lipopolysaccharide-induced acute lung injury2011
- Author(s)
  Naito M, Taguchi O, Takagi T, Kobayashi T, D' Alessandro-Gabazza CN, Gabazza EC.
- Organizer
  European Respiratory Society International Congress
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-21590133
[Presentation] Protective effect of thrombomodulin in a murine model of allergen-induced asthma2010
- Author(s)
  Takagi T, Taguchi O, Toda M, Kobayashi H, Kobayashi T, Fujiwara A, Naito M, D' Alessandro-Gabazza CN, Boveda-Ruiz D, Gil-Bernabe P, Morser J, Gabazza EC.
- Organizer
  The 14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-21590133
[Presentation] 呼吸器疾患に対するsiRNA創薬の可能性2010
- Author(s)
  小林哲, 他
- Organizer
  アレルギー気道上皮細胞研究会
- Place of Presentation
  シェーンバッハ・サボー(東京)
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-22590859
[Presentation] Protective effect of thrombomodulin in a murine model of allergen-induced asthma2010
- Author(s)
  Takagi T, Taguchi O, Naito M, Toda M, Kobayashi T, Miyake Y, Boveda-Ruiz D, D' Alessandro-Gabazza CN, Morser J, Gabazza EC.
- Organizer
  Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21590133
[Presentation] Protective effect of thrombomodulin-positive dendritic cells against murine asthma2010
- Author(s)
  Fujiwara A, Urawa M, Naito M, Takagi T, Ebihara A, Kobayashi T, Kobayashi H, D' Alessandro-Gabazza CN, Takei Y, Gabazza EC, Taguchi O.
- Organizer
  European Respiratory Society International Congress
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21590133
[Presentation] Protective effect of thrombomodulin-positive dendritic cells against murine asthma2010
- Author(s)
  Naito M, Takagi T, Taguchi O, Toda M, Kobayashi H, Kobayashi T, Fujiwara A, D' Alessandro-Gabazza CN, Boveda-Ruiz D, Morser J and Gabazza EC.
- Organizer
  The 14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-21590133
[Presentation] Role of thrombin-activatable fibrinolysis inhibitor in lipopolysaccharide-induced acute lung injury2010
- Author(s)
  Naito M, Taguchi O, Takagi T, Toda M, Kobayashi T, Miyake Y, Boveda-Ruiz D, D' Alessandro-Gabazza CN, Morser J, Takei Y, Gabazza EC.
- Organizer
  Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21590133
[Presentation] 呼吸器疾患におけるsiRNA治療戦略2009
- Author(s)
  小林哲, 他
- Organizer
  第78回閉塞性肺疾患研究会
- Place of Presentation
  東京
- Year and Date
  2009-01-24
- Data Source
  KAKENHI-PROJECT-19590893
[Presentation] Role of thrombin-activatable fibrinolysis inhibitor in bronchial asthma2009
- Author(s)
  Takagi T, Naito M, Fujiwara A, Fujimoto H, Ebihara A, Yasui H, Kobayashi T, Kobayashi H, D' Alessandro-Gabazza CN, Gabazza EC, Takei Y, Taguchi O.
- Organizer
  European Respiratory Society International Congress
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-21590133
[Presentation] Procoagulant and Anticoagulant Factors inPatients with Sleep Apnea2009
- Author(s)
  M. Naito, T. Takagi, A. Fujiwara, A.Yamaguchi, T. Kobayashi, H. Kobayashi,C.N. D'Alessandro-Gabazza, J. Morser, E.C.Gabazza, Y. Takei, O. Taguchi
- Organizer
  ATS International Congress
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2009-05-18
- Data Source
  KAKENHI-PROJECT-19590893
[Presentation] Effect of a thrombin inhibitor on murine bronchial asthma2009
- Author(s)
  Fujiwara A, Naito M, Takagi T, Ebihara A, Kobayashi T, Kobayashi H, D' Alessandro-Gabazza CN, Gabazza EC, Takei Y, Taguchi O.
- Organizer
  European Respiratory Society International Congress
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-21590133
[Presentation] ProteinS Inhibits the Secretion of InflammatoryCytokines from Alveolar Epithelial Cells2009
- Author(s)
  M. Naito, T. Takagi, A. Fujiwara, A.Yamaguchi, T. Kobayashi, H. Kobayashi,C.N. D'Alessandro-Gabazza , J. Morser,E.C. Gabazza, Y. Takei, O. Taguchi
- Organizer
  ATS International Congress
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2009-05-18
- Data Source
  KAKENHI-PROJECT-19590893
[Presentation] Circulating Fibrocytes in Bronchial Asthma2009
- Author(s)
  H. Kobayashi, M. Masuya, M. Naito, A.Fujiwara, T. Takagi, A. Yamaguchi, T.Kobayashi, E.C. Gabazza, O. Taguchi
- Organizer
  ATS International Congress
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2009-05-18
- Data Source
  KAKENHI-PROJECT-19590893
[Presentation] 組織リモデリングにおけるMatrix metalloproteinase-9 の役割2008
- Author(s)
  小林哲
- Organizer
  第11回間質性肺炎細胞分子病態研究会
- Place of Presentation
  東京
- Year and Date
  2008-08-23
- Data Source
  KAKENHI-PROJECT-19590893
[Presentation] Matrixmetalloproteinase-9 modulates fibroblastactivity through autocrine TGF-b2008
- Author(s)
  T.Kobayashi, et.al.
- Organizer
  6th ERS Lung Science Conference
- Place of Presentation
  Estoril, Portugal
- Year and Date
  2008-05-14
- Data Source
  KAKENHI-PROJECT-19590893
[Presentation] 組織りモデリングにおけるMMP-9の役割2008
- Author(s)
  小林哲, 他
- Organizer
  間質性肺炎細胞分子病態研究会
- Place of Presentation
  シェーンバッハ・サボー(東京)
- Year and Date
  2008-08-23
- Data Source
  KAKENHI-PROJECT-19590893
[Presentation] Mmatrix metalloproteinase-9のリモデリングにおける役割2007
- Author(s)
  小林哲, 他.
- Organizer
  アレルギー・気道上皮細胞研究会第11回学術大会
- Place of Presentation
  シェーンバッハ・サボー(東京)
- Year and Date
  2007-12-08
- Data Source
  KAKENHI-PROJECT-19590893
[Presentation] 薬剤中止にて迅速に改善したメサラジンによる薬剤性肺障害の1例
- Author(s)
  藤原　研太郎、浦田　健太郎、都丸　敦史、高橋　佳紀、大西　真裕、高木　健裕、小林　哲、小林　裕康、田口　修、Esteban C. Gabazza
- Organizer
  第124回日本結核病学会東海地方大会
- Place of Presentation
  静岡　アクトシティ浜松コングレスセンター
- Year and Date
  2014-11-29 – 2014-11-30
- Data Source
  KAKENHI-PROJECT-24591128
[Presentation] 呼吸器疾患におけるRNAiを用いた治療開発の可能性
- Author(s)
  小林　哲
- Organizer
  第53回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461189
[Presentation] The lung microbiome using mouse disease model
- Author(s)
  Kobayashi Tetsu, Toda Masaaki, D’Alessandro- Gabazza Corina N., Takagi Takehiro, Chelakkot Govindalayathil Ayshwarya L., Roeen Ziaurahman, Urawa Masahito, Onishi Masahiro, Fujiwara Kentaro, Tomaru Atsushi, Taguchi Osamu, Gabazza Esteban
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都　国立京都国際会館
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24591128
[Presentation] 呼吸器疾患におけるRNAiを用いた創薬の可能性
- Author(s)
  小林　哲
- Organizer
  第16回間質性肺炎細胞分子病態研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461189
[Presentation] 呼吸器疾患におけるRNAiを用いた治療開発の可能性
- Author(s)
  小林哲、ガバザエステバン、その他
- Organizer
  日本呼吸器学会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24591128
[Presentation] A novel and short-term mouse model of chronic obstructive pulmonary disease
- Author(s)
  O.Hataji,A.L.Chelakkot-Govindalayathil, C.N.D’Alessandro-Gabazza, M. Onishi, K. Fujiwara, M.Toda, T.Kobayashi, E.C.Gabazza, O. Taguchi.
- Organizer
  ERS Munich, Germany
- Place of Presentation
  ドイツ　ミュンヘン
- Year and Date
  2014-09-06 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-24591128

1. ESTEBAN Gabazza (00293770)

# of Collaborated Projects: 10 results

# of Collaborated Products: 148 results
2. TAGUCHI Osamu (90197244)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. 戸田雅昭 (10202201)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
4. GABAZZA CORINA (10750656)

# of Collaborated Projects: 2 results

# of Collaborated Products: 41 results
5. 安間太郎 (80773887)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
6. 藤本源 (90378399)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
7. MORSER John (40571625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. NAKAHARA Hiroki (30757092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 竹下敦郎 (10830490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 矢野裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 藤澤隆夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 細木興亜

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 都丸敦史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 野阪哲哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Tetsu 小林 哲

KOBAYASHI Tetsu 小林 哲

Research Projects

Research Products

Co-Researchers

細菌叢由来ペプチドによる肺線維症発症メカニズム解明と抑制方法の開発Principal Investigator

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COVID-19における肺傷害促進因子Corisinの検討

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The role of the lung microbiota-derived proapoptotic peptide (corisin) in COPD

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Microbiome in the Development of Lung CancerPrincipal Investigator

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Investigating the role of mucin in pulmonary fibrosis-associated microbiota dysbiosis using MUC5B overexpressing mice

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Evaluating the role of the lung microbiome in pulmonary fibrosis

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Development of novel therapeutic approaches for pulmonary fibrosis using MUC5B overexpressing mice

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RNAi for the treatment of refractory pulmonary diseasesPrincipal Investigator

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Development of new therapeutic strategies for chronic obstructive diseases using RNA interference

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siRNA for the treatment of airway remodelingPrincipal Investigator

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EVALUATING THE PATHOGENESIS AND DEVELOPMENT OF NOVEL THERAPIES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE USING GENE-ENGINEERED MICE

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Epithelial mesenchymal transition during airway remodelingPrincipal Investigator

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[Book] Annual Review 2016 呼吸器2016

Author(s)

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Kobayashi Tetsu 小林哲

KOBAYASHI Tetsu 小林哲