HEMMI HIROAKI 邊見弘明

… Alternative Names

HEMMI Hiroaki 邊見弘明

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Researcher Number	20451924
Other IDs
Affiliation (Current)	2025: 岡山理科大学, 獣医学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 岡山理科大学, 獣医学部, 教授 2014 – 2018: 和歌山県立医科大学, 先端医学研究所, 准教授 2012 – 2013: 大阪大学, 免疫学フロンティア研究センター, 寄附研究部門准教授 2011: 大阪大学, 免疫学フロンティア研究センター, 寄附研究部門助教 2010: 独立行政法人理化学研究所, 生体防御研究チーム, 研究員 2007 – 2009: Tokyo Medical and Dental University, 難治疾患研究所, 特任講師 2008: 医科歯科大, 難治疾患研究所
Review Section/Research Field	Principal Investigator Experimental pathology / Basic Section 49030:Experimental pathology-related Except Principal Investigator Basic Section 53050:Dermatology-related / Dermatology
Keywords	Principal Investigator 樹状細胞 / プロテアソーム / マクロファージ / 免疫プロテアソーム / 遺伝子変異 / 遺伝子改変マウス / 炎症 / 免疫応答 / サブセット / イムノグロブリンスパーファミリー … More / 細胞機能 / 造血 / 免疫細胞分化 / 細胞分化 / 遺伝子バリアント / モデルマウス / 免疫担当細胞分化 / 自然免疫機構 / 単球 / 自然免疫 / 免疫寛容 / 樹状細部 / 腸管 / 免疫制御 / 受容体 / イムノグロブリンスーパーファミリー / 死細胞 / サイトカイン産生 / 分子 / DAP12 … More Except Principal Investigator インタ－フェロン制御異常症 / 自己炎症性疾患 / 新規遺伝子変異 / インターフェロン制御異常症 / 凍瘡様皮疹 / 中條-西村症候群 / プロテアソーム / ノックインマウス / 中條ー西村症候群 / PSMB8 / proteasome / Nakajo-Nishimura / autoinflammatory / PSMB9 Less

免疫プロテアソーム異常による疾患の病態と機能的意義の解明Principal Investigator
- Principal Investigator
  
  邊見弘明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Okayama University of Science
Analysis of immunoproteasome function in immune cell developmentPrincipal Investigator
- Principal Investigator
  
  Hemmi Hiroaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Okayama University of Science
Identification and analysis of novel inherited dysregulation of interferon
- Principal Investigator
  
  Kunimoto Kayo
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Wakayama Medical University
Analysis of the immunoproteasome function in innate immunityPrincipal Investigator
- Principal Investigator
  
  Hemmi Hiroaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Okayama University of Science
  Wakayama Medical University
Elucidation of the pathological significance of a novel PSMB9 mutation in a sporadic case with Nakajo-Nishimura syndrome-like symptoms
- Principal Investigator
  
  Kunimoto Kayo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Wakayama Medical University
Analysis of dendritic cell functions in peripheral tissuesPrincipal Investigator
- Principal Investigator
  
  Hemmi Hiroaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Wakayama Medical University
Analysis of dendritic cell function in immune responsesPrincipal Investigator
- Principal Investigator
  
  HEMMI Hiroaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Wakayama Medical University
  Osaka University
Functional analysis of Trem-like 4 in micePrincipal Investigator
- Principal Investigator
  
  HEMMI Hiroaki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Osaka University
  The Institute of Physical and Chemical Research
Functional analysis of a new Trem moleculePrincipal Investigator
- Principal Investigator
  
  HEMMI Hiroaki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Medical and Dental University
樹状細胞・マクロファージ等に発現している新規Trem分子の機能解析Principal Investigator
- Principal Investigator
  
  邊見弘明
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Medical and Dental University

[Journal Article] Tmem45b is essential for inflammation- and tissue injury?induced mechanical pain hypersensitivity2022
- Author(s)
  Tanioku Tadashi、Nishibata Masayuki、Tokinaga Yasuyuki、Konno Kohtaro、Watanabe Masahiko、Hemmi Hiroaki、Fukuda-Ohta Yuri、Kaisho Tsuneyasu、Furue Hidemasa、Kawamata Tomoyuki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 45 Pages: 119-119
- DOI
  10.1073/pnas.2121989119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06956, KAKENHI-PLANNED-22H05187, KAKENHI-PROJECT-20H03505, KAKENHI-PROJECT-20H04043, KAKENHI-PROJECT-21K19384, KAKENHI-PROJECT-23K24428
[Journal Article] Expression profile of immunoregulatory factors in canine tumors2022
- Author(s)
  Murakami Kohei、Miyatake Saki、Miyamae Jiro、Saeki Kanna、Shinya Mizutani、Akashi Natsuki、Mitsui Ikki、Kobayashi Kosuke、Saeki Kohei、Maeta Noritaka、Kanda Teppei、Okamura Yasuhiko、Hemmi Hiroaki
- Journal Title
  
  Veterinary Immunology and Immunopathology
  
  Volume: 253 Pages: 110505-110505
- DOI
  10.1016/j.vetimm.2022.110505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06956, KAKENHI-PROJECT-21K09216
[Journal Article] Augmentation of STING‐induced type I interferon production in COPA syndrome2021
- Author(s)
  Kato Takashi、Yamamoto Masaki、Honda Yoshitaka、Orimo Takashi、Sasaki Izumi、Murakami Kohei、Hemmi Hiroaki、Fukuda‐Ohta Yuri、Isono Kyoichi、Takayama Saki、Nakamura Hidenori、Otsuki Yoshiro、Miyamoto Toshiaki、Takita Junko、Yasumi Takahiro、Nishikomori Ryuta、Matsubayashi Tadashi、Izawa Kazushi、Kaisho Tsuneyasu
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: in press Issue: 11 Pages: 2105-2115
- DOI
  10.1002/art.41790
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-18K16096, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-20K16289, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-20H03505, KAKENHI-PROJECT-21J22615, KAKENHI-PROJECT-21K06956, KAKENHI-PROJECT-21K09216, KAKENHI-PROJECT-21K19384, KAKENHI-PROJECT-21K19405
[Journal Article] Radiation inducible MafB gene is required for thymic regeneration2021
- Author(s)
  Daiki Hashimoto, Jose Gabriel R. Colet, Aki Murashima, Kota Fujimoto, Yuko Ueda, Kentaro Suzuki, Taiju Hyuga, Hiroaki Hemmi, Tsuneyasu Kaisho, Satoru Takahashi, Yousuke Takahama and Gen Yamada1
- Journal Title
  
  Scientific Reports
  
  Volume: - Issue: 1 Pages: 10439-10439
- DOI
  10.1038/s41598-021-89836-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07229, KAKENHI-PROJECT-17K08495, KAKENHI-PROJECT-18K07071, KAKENHI-PROJECT-20H03505, KAKENHI-PROJECT-21K06956, KAKENHI-PROJECT-21K19538, KAKENHI-PROJECT-20K18150
[Journal Article] Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency2021
- Author(s)
  Kanazawa N, Hemmi H, Kinjo N, Ohnishi H, Hamazaki J, M.H, K.A, M.T, H.S, K.N, K.S, H.Y, I.K, N.R, T.M, Y.Y, T.S, O.T, O.T, K.T, S.I, F.Y, W.N, I.Y, K.K, O.S, T.T, N.K, M.S, Y.K, Kaisho T
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 0-0
- DOI
  10.1038/s41467-021-27085-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07062, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-20K16289, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-20H03505, KAKENHI-PROJECT-20H03591, KAKENHI-PROJECT-21J22615, KAKENHI-PROJECT-19K08754, KAKENHI-PROJECT-19K08798, KAKENHI-PROJECT-19K09993, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-21K06956, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-21K07800, KAKENHI-PROJECT-21K19384, KAKENHI-PROJECT-20K17405
[Journal Article] Immunogenic tumor cell death promotes dendritic cell migration and inhibits tumor growth via enhanced T cell immunity2021
- Author(s)
  Moriya Taiki、Kitagawa Kurumi、Hayakawa Yuuki、Hemmi Hiroaki、Kaisho Tsuneyasu、Ueha Satoshi、Ikebuchi Ryoyo、Yasuda Ippei、Nakanishi Yasutaka、Honda Tetsuya、Matsushima Koji、Kabashima Kenji、Ueda Mizuki、Kusumoto Yutaka、Chtanova Tatyana、Tomura Michio
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 5 Pages: 102424-102424
- DOI
  10.1016/j.isci.2021.102424
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-18K07071, KAKENHI-PROJECT-20H03505, KAKENHI-PROJECT-21K19384, KAKENHI-PROJECT-18K14598
[Journal Article] Anticancer effects of chemokine-directed antigen delivery to a cross-presenting dendritic cell subset with immune checkpoint blockade2020
- Author(s)
  Mizumoto Y, Hemmi H, Katsuda M, Miyazawa M, Kitahata Y, Miyamoto A, Nakamori M, Ojima T, Matsuda K, Nakamura M, Hayata K, Fukuda-Ohta Y, Sugiyama M, Ohta T, Orimo T, Okura S, Sasaki I, Tamada K, Yamaue H, Kaisho T.
- Journal Title
  
  British Journal of Cancer
  
  Volume: 122 Issue: 8 Pages: 1185-1193
- DOI
  10.1038/s41416-020-0757-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07071, KAKENHI-PROJECT-19K09183, KAKENHI-PROJECT-18K16096, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17K10603, KAKENHI-PROJECT-17K10604, KAKENHI-PROJECT-17K10711, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-20K09063, KAKENHI-PROJECT-19K18101, KAKENHI-PROJECT-20K16289, KAKENHI-PROJECT-17H01580, KAKENHI-PROJECT-19K23848
[Journal Article] The mechanism of action of Spi-B in the transcriptional activation of the interferon-α4 gene.2020
- Author(s)
  R. Miyazaki, H. Saiga, T. Kato, T. Bakoshi, R. Senba, A. Shintani, M. Suzuki, K. Takao, I. Sasaki, A. Iizuka, M. Sugiyama, N. Iwami, Y. Fukuda-Ohta, H. Hemmi, T. Tanaka, M. Miyake, T. Kaisho, K. Hoshino.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 30;525 Issue: 2 Pages: 477-482
- DOI
  10.1016/j.bbrc.2020.02.101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16096, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-18K07071
[Journal Article] Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9‐genome editing promotes antitumor immunity and suppresses ovarian cancer progression2019
- Author(s)
  Yahata T, Mizoguchi M, Kimura A, Orimo T, Toujima S, Kuninaka Y, Nosaka M, Ishida Y, Sasaki I, Fukuda‐Ohta Y, Hemmi H, Iwahashi N, Noguchi T, Kaisho T, Kondo T, Ino K
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 4 Pages: 1279-1292
- DOI
  10.1111/cas.13958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07071, KAKENHI-PROJECT-18K10134, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-18K16096, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17K11293, KAKENHI-PROJECT-17K16863
[Journal Article] Hyperglycemia is associated with psoriatic inflammation in both humans and mice2019
- Author(s)
  Ikumi K, Odanaka M, Shime H, Imai M, Osaga S, Taguchi O, Nishida E, Hemmi H, Kaisho T, Morita A, Yamazaki S
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 印刷中 Issue: 6 Pages: 1329-1338
- DOI
  10.1016/j.jid.2019.01.029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07071, KAKENHI-PUBLICLY-17H05798, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-16H05177, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-16K08704, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-19K07510, KAKENHI-PROJECT-19KK0202, KAKENHI-PUBLICLY-19H04812, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17H04242, KAKENHI-PROJECT-17K11679
[Journal Article] Cholera toxin B induces interleukin-1β production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome2019
- Author(s)
  Orimo T, Sasaki I, Hemmi H, Ozasa T, Fukuda-Ohta Y, Ohta T, Morinaka M, Kitauchi M, Yamaguchi T, Sato Y, Tanaka T, Hoshino K, Katayama KI, Fukuda S, Miyake K, Yamamoto M, Satoh T, Furukawa K, Kuroda E, Ishii KJ, Takeda K, Kaisho T
- Journal Title
  
  International Immunology
  
  Volume: 印刷中 Issue: 10 Pages: 657-668
- DOI
  10.1093/intimm/dxz004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07071, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-19K22518, KAKENHI-PROJECT-18K16096, KAKENHI-PROJECT-19K23848, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17K19616, KAKENHI-PROJECT-18H02628
[Journal Article] Identification of a novel CCDC22 mutation in a patient with severe Epstein?Barr virus-associated hemophagocytic lymphohistiocytosis and aggressive natural killer cell leukemia2019
- Author(s)
  Yamashita Y, Nishikawa A, Iwahashi Y, Fujimoto M, Sasaki I, Mishima H, Kinoshita A, Hemmi H, Kanazawa N, Ohshima K, Imadome KI, Murata SI、Yoshiura KI, Kaisho T, Sonoki T, Tamura S
- Journal Title
  
  International Journal of Hematology
  
  Volume: 印刷中 Issue: 6 Pages: 744-750
- DOI
  10.1007/s12185-019-02595-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07071, KAKENHI-PROJECT-18K07850, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-19K08821, KAKENHI-PROJECT-19K22913, KAKENHI-PROJECT-18KK0245, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-16KT0112
[Journal Article] 生体内における樹状細胞への腫瘍抗原送達システムによる新規がんペプチドワクチン療法2018
- Author(s)
  水本有紀、勝田将裕、宮澤基樹、北畑裕司、宮本篤、中森幹人、尾島敏康、松田健司、邊見弘明、玉田耕治、改正恒康、山上裕機
- Journal Title
  
  癌と化学療法
  
  Volume: 45 Pages: 1469-1471
- Data Source
  KAKENHI-PROJECT-18K07071
[Journal Article] Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration.2017
- Author(s)
  4.Y. Ishida, A. Kimura, M. Nosaka, Y. Kuninaka, H. Hemmi, I. Sasaki, T. Kaisho, N. Mukaida, T. Kondo.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 16833-16833
- DOI
  10.1038/s41598-017-17007-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-26293163, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-15K08431, KAKENHI-PROJECT-15K08880
[Journal Article] Ultraviolet B?Induced Maturation of CD11b-Type Langerin?Dendritic Cells Controls the Expansion of Foxp3+Regulatory T Cells in the Skin2017
- Author(s)
  Yamazaki Sayuri、Odanaka Mizuyu、Nishioka Akiko、Kasuya Saori、Shime Hiroaki、Hemmi Hiroaki、Imai Masaki、Riethmacher Dieter、Kaisho Tsuneyasu、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 200 Issue: 1 Pages: 119-129
- DOI
  10.4049/jimmunol.1701056
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08704, KAKENHI-PROJECT-17K11679, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-16H06295, KAKENHI-PUBLICLY-17H05798, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-16H05177, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-15K08431, KAKENHI-PROJECT-16K15259, KAKENHI-PROJECT-16K15376, KAKENHI-PROJECT-17H04242
[Journal Article] Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis.2016
- Author(s)
  Ohta T, Sugiyama M, Hemmi H, Yamazaki C, Okura S, Sasaki I, Fukuda Y, Orimo T, Ishii KJ, Hoshino K, Ginhoux F, Kaisho T.
- Journal Title
  
  Scientific Reports
  
  Volume: 162 Issue: 1 Pages: 23505-23505
- DOI
  10.1038/srep23505
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08431, KAKENHI-PROJECT-26461465, KAKENHI-PROJECT-15K19077, KAKENHI-PROJECT-14J04735, KAKENHI-PROJECT-26293106, KAKENHI-PROJECT-16K19585
[Journal Article] In vivo ablation of dendritic cell subset expressing the chemokine receptor XCR1.2016
- Author(s)
  H. Hemmi, K. Hoshino, T. Kaisho.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1423 Pages: 247-53
- DOI
  10.1007/978-1-4939-3606-9_17
- ISBN
  9781493936045, 9781493936069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293106, KAKENHI-PROJECT-15K08431, KAKENHI-PROJECT-26461465
[Journal Article] Homeostasis of thymus-derived Foxp3+ regulatory T cells is controlled by ultraviolet B exposure in the skin.2014
- Author(s)
  S. Yamazaki, A. Nishioka, S. Kasuya, N. Ohkura, H. Hemmi, T. Kaisho, O. Taguchi, S. Sakaguchi, A. Morita
- Journal Title
  
  J Immunol
  
  Volume: 193(11) Issue: 11 Pages: 5488-97
- DOI
  10.4049/jimmunol.1400985
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117003, KAKENHI-PROJECT-24590460, KAKENHI-PROJECT-26293106, KAKENHI-PROJECT-26670192
[Journal Article] Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria.2014
- Author(s)
  H. Zhao, T. Aoshi, S. Kawai, Y. Mori, A. Konishi, M. Ozkan, Y. Fujita, Y. Haseda, M. Shimizu, M. Kohyama, K. Kobiyama, K. Eto, J. Nabekura, T. Horii, T. Ishino, M. Yuda, H. Hemmi, T. Kaisho, S. Akira, M. Kinoshita, K. Tohyama, Y. Yoshioka, K. J. Ishii, C. Coban
- Journal Title
  
  Cell Host Microbe
  
  Volume: 15 Issue: 5 Pages: 551-563
- DOI
  10.1016/j.chom.2014.04.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21117003, KAKENHI-PROJECT-23228001, KAKENHI-PROJECT-23390124, KAKENHI-PROJECT-24249024, KAKENHI-PROJECT-24249077, KAKENHI-PROJECT-24590460, KAKENHI-PROJECT-24590584, KAKENHI-PROJECT-25253027, KAKENHI-PROJECT-25293100, KAKENHI-PROJECT-26293106, KAKENHI-PROJECT-26860996
[Journal Article] Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR12013
- Author(s)
  C. Yamazaki, M. Sugiyama, T. Ohta, H. Hemmi, E. Hamada, I. Sasaki, Y. Fukuda, T. Yano, M. Nobuoka, T. Hirashima, A. Iizuka, K. Sato, T. Tanaka, K. Hoshino, T. Kaisho
- Journal Title
  
  J. Immunol
  
  Volume: 190 Issue: 12 Pages: 6071-6082
- DOI
  10.4049/jimmunol.1202798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390124, KAKENHI-PROJECT-23590577, KAKENHI-PROJECT-23659245, KAKENHI-PROJECT-24590460, KAKENHI-PROJECT-25293117, KAKENHI-PROJECT-25870401
[Journal Article] Treml4, an Ig Superfamily Member, Mediates Presentation of Several Antigens to T Cells In Vivo, Including Protective Immunity to HER2 Protein2012
- Author(s)
  Hiroaki Hemmi, Neeha Zaidi, Bei Wang, Ines Matos, Christopher Fiorese, Ashira Lubkin, Lori Zbytnuik, Koji Suda, Kenneth Zhang, Masaki Noda, Tsuneyasu Kaisho, Ralph M. Steinman, and Juliana Idoyaga
- Journal Title
  
  J Immunol
  
  Volume: 188 Issue: 3 Pages: 1147-1155
- DOI
  10.4049/jimmunol.1102541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790376, KAKENHI-PROJECT-23390124, KAKENHI-PROJECT-23659245, KAKENHI-PROJECT-23659868, KAKENHI-PLANNED-21117003
[Journal Article] CD8陽性樹状細胞サブセットの動的制御機構の解析2012
- Author(s)
  邊見弘明, 山崎千尋, 星野克明, 改正恒康
- Journal Title
  
  Cytometry Research
  
  Volume: 22 Pages: 31-35
- NAID
  10030199789
- URL
  http://www.cytometry.jp/scientist/journals/%E3%83%90%E3%83%83%E3%82%AF%E3%83%8A%E3%83%B3%E3%83%90%E3%83%BC
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790376
[Journal Article] Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice2010
- Author(s)
  Yamazaki, C., Miyamoto, R., Hoshino, K., Fukuda, Y., Sasaki, I., Saito, M., Ishiguchi, H., Yano, T., Sugiyama, T., Hemmi, H., Tanaka, T., Hamada, E., Hirashima, T., Amakawa, R., Fukuhara, S., Nomura, S., Ito, T., and Kaisho, T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 397 Issue: 4 Pages: 756-761
- DOI
  10.1016/j.bbrc.2010.06.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590444, KAKENHI-PROJECT-22790376
[Journal Article] A new triggering receptor expressed on myeloid cells(Trem)family member, them-like 4, binds to dead cells and is DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells2009
- Author(s)
  H. Hemmi, et.al.
- Journal Title
  
  The Journal of Immunology 182
  
  Pages: 1278-1286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790299
[Journal Article] A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells.2009
- Author(s)
  Hiroaki Hemmi, Juliana Idoyaga, Koji Suda, Nao Suda, Kathleen Kennedy, Masaki Noda, Alan Aderem, Ralph M. Steinman
- Journal Title
  
  Journal of Immunology 182
  
  Pages: 1278-1286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790299
[Journal Article] Innate Valpha 14 (+) natural killer T cells mature dendritic cells, leading to strong adaptive immunity2007
- Author(s)
  S. Fujii, K. Shimizu, H. Hemmi, R.M. Steinman
- Journal Title
  
  lmmunol Rev. 220
  
  Pages: 183-198
- Data Source
  KAKENHI-PROJECT-19890063
[Presentation] Impaired plasma cell differentiation in a novel model mouse of the proteasome-associated autoinflammatory syndromes with immunodeficiency.2023
- Author(s)
  Takashi Kato, Asumi Yamamoto, Izumi Sasaki, Naoko Wakaki-Nishiyama, Hiroaki Hemmi, Nobuo Kanazawa, Wataru Ise, Tsuneyasu Kaisho.
- Organizer
  The 29th International Symposium on Molecular Cell Biology of Macrophages. (ISICR/MMCB2023 Joint Symposium)
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Impairment of plasma cell generation in mice carrying a proteasome subunit β1i missense mutation derived from patients with autoinflammation and adaptive immune deficiency2023
- Author(s)
  Takashi Kato, Asumi Yamamoto, Izumi Sasaki, Naoko Wakaki-Nishiyama, Hiroaki Hemmi, Nobuo Kanazawa, Wataru Ise and Tsuneyasu Kaisho
- Organizer
  JAM on Cell Death, 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Dendritic cells and T cell abnormalities in a novel mouse model of COPA syndrome2022
- Author(s)
  Takashi Kato, Asumi Yamamoto, Izumi Sasaki, Naoko Wakaki-Nishiyama, Kohei Murakami, Hiroaki Hemmi, Yoshitaka Honda, Kazushi Izawa, Ryuta Nishikomori, Tsuneyasu Kaisho
- Organizer
  JSICR/MMCB 2022 Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] COPA症候群の新規モデルマウスにおけるSTINGの活性化とT細胞の異常2022
- Author(s)
  加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、村上康平、邊見弘明、本田吉孝、井澤和司、八角高裕、大月寛郎、松林正、西小森隆太、改正恒康
- Organizer
  第5回日本免疫不全・自己炎症学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] 和歌山からの研究発信　―自己炎症性疾患―2022
- Author(s)
  改正恒康, 金澤伸雄, 邊見弘明, 佐々木泉, 加藤喬, 山本明日美
- Organizer
  第90回和歌山医学会
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] 免疫不全を伴うプロテアソーム関連自己炎症症候群モデルマウスの解析2022
- Author(s)
  邊見弘明
- Organizer
  第20回四国免疫フォーラム
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Activation of type I Interferon signaling in dendritic cells and T cells of the mouse model of COPA syndrome2022
- Author(s)
  Takashi Kato, Ryota Yamasaki, Naoko Wakaki Nishiyama, Izumi Sasaki, Shiori Kaji, Kohei Murakami, Hiroaki Hemmi, Yoshitaka Honda, Kazushi Izawa, Yoshiro Otsuki, Tadashi Matsubayashi, Ryuta Nishikomori, Tsuneyasu Kaisho
- Organizer
  日本免疫毒性学会　第29回学術年会
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Chemokine-medicated delivery of cancer peptide vaccine to a dendritic cell subset with high crosspresentation activity2021
- Author(s)
  Yuki Mizumoto, Hiroaki Hemmi, Masahiro Katsuda, Yuri Fukuda-Ohta, Takashi Orimo, Izumi Sasaki, Koji Tamada, Hiroki Yamaue, Tsuneyasu Kaisho
- Organizer
  The 27th International Symposium on Molecular Cell Biology of Macrophages
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Impaired development of myeloid cells in proteasome subunit mutant mice2021
- Author(s)
  Hiroaki Hemmi, Takashi Orimo, Izumi Sasaki, Takashi Kato, Yuri Fukuda-Ohta, Noriko Kinjo, Hidenori Ohnishi, Nobuo Kanazawa, Tsuneyasu Kaisho
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Interstitial Lung Disease and abnormal STING activation in COPA V242G heterozygous variant mice2021
- Author(s)
  Takashi Kato, Takashi Orimo, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Chihiro Nakai, Izumi Sasaki, Kohei Murakami, Hiroaki Hemmi, Yoshitaka Honda, Kazushi Izawa, Yoshiro Otsuki, Tadashi Matsubayashi, Ryuta Nishikomori, Tsuneyasu Kaisho
- Organizer
  16th Meeting of the International Endotoxin and Innate Immunity Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] XCR1+ DC をターゲットにしたwhole-cell-vaccine の開発2021
- Author(s)
  宮本篤、勝田将裕、宮澤基樹、北畑裕司、水本有紀、小林良平、尾島敏康、邊見弘明、戸村道夫、改正恒康、山上裕機
- Organizer
  第25回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Hypomorphic mutation of Lig4 gene in mice predisposes to intestinal inflammation driven by CD4+ Th1 cells2021
- Author(s)
  Yusuke Yamashita, Takashi Orimo, Takashi Kato, Yuri Fukuda-Ohta, Izumi Sasaki, Hiroaki Hemmi, Shinobu Tamura, Tsuneyasu Kaisho
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] 樹状細胞サブセット(XCR1+DC) への特異的送達によるがんペプチドワクチン療法2021
- Author(s)
  水本有紀、勝田将裕、宮澤基樹、北畑裕司、宮本篤、中森幹人、松田健司、尾島敏康、邊見弘明、玉田耕治、改正恒康、山上裕機
- Organizer
  第25回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Sublingual dendritic cell (DC) - T cell clusters and distribution of DCs in the oral cavity2021
- Author(s)
  Yutaka Kusumoto, Tsuneyasu Kaisho, Hiroaki Hemmi, Tomoya Katakai, Tetsuya Honda, Junichi Kikuta, Kousuke Kataoka, Taiki Moriya, Masaru Ishii, Kenji Kabashima, Michio Tomura
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Unique location in the immunoproteasome complex of a variant causing proteasome-associated autoinflammatory syndrome with immunodeficiency2021
- Author(s)
  Nobuo Kanazawa, Hiroaki Hemmi, Noriko Kinjo, Hidenori Ohnishi, Jun Hamazaki, Hiroyuki Mishima, Akira Kinoshita, Tsunehiro Mizushima, Shigeo Murata, Koh-ichiro, Yoshiura, Tsuneyasu Kaisho
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] 自己炎症性疾患COPA症候群変異マウスにおけるSTINGシグナルの活性化2021
- Author(s)
  加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、張江伊水、田中日向子、佐々木泉、村上康平、邊見弘明、本田吉孝、井澤和司、西小森隆太、改正恒康
- Organizer
  第85回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Impaired monocyte and dendritic cell development in mice carrying a mutation identified from the proteasome-associated autoinflammation and immunodeficiency disease patient2021
- Author(s)
  Hiroaki Hemmi, Takashi Orimo, Naoko Nishiyama, Takashi Kato, Toshiya Ozasa, Izumi Sasaki, Hidenori Ohnishi, Noriko Kinjo, Nobuo Kanazawa, Tsuneyasu Kaisho
- Organizer
  The 27th International Symposium on Molecular Cell Biology of Macrophages
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Molecular mechanisms of type I interferonopathy in a novel COPA syndrome model mouse2021
- Author(s)
  Takashi Kato, Takashi Orimo, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Chihiro Nakai, Izumi Sasaki, Kohei Murakami, Hiroaki Hemmi, Yoshitaka Honda, Kazushi Izawa, Yoshiro Otsuki, Tadashi Matsubayashi, Ryuta Nishikomori, Tsuneyasu Kaisho
- Organizer
  第28回日本免疫毒性学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] XCR1 陽性樹状細胞分化におけるプロテアソームの役割2021
- Author(s)
  西山奈央子、佐々木泉、邊見弘明、改正恒康
- Organizer
  第25回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Hyperactivation of STING-induced type I interferon pathway in dendritic cells from novel mice model for an autoinflammatory disease, COPA syndrome2021
- Author(s)
  Takashi Kato, Takashi Orimo, Yuri Fukuda-Ohta, Sasaki Izumi. Hiroaki Hemmi, Yoshitaka Honda, Kazushi Izawa, Ryuta Nishikomori, Tsuneyasu Kaisho
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Augmented STING signaling in a new mouse model of COPA syndrome. The 27th International Symposium on Molecular Cell Biology of Macrophages2021
- Author(s)
  Takashi Kato, Takashi Orimo, Yuri Fukuda-Ohta, Naoko Nishiyama, Izumi Sasaki, Hiroaki Hemmi, Yoshitaka Honda, Kazushi Izawa, Ryuta Nishikomori, Tsuneyasu Kaisho
- Organizer
  The 27th International Symposium on Molecular Cell Biology of Macrophages
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] The role of IRE1α in cholera toxin B-induced interleukine-1β production from resident peritoneal macrophages. The 27th International Symposium on Molecular Cell Biology of Macrophages2021
- Author(s)
  Izumi Sasaki, Chihiro Nakai, Shuhei Morita, Daisuke Okuzaki, Yuri Fukuda-Ohta, Takashi Orimo, Hiroaki Hemmi, Koichi Furukawa, Tsuneyasu Kaisho
- Organizer
  The 27th International Symposium on Molecular Cell Biology of Macrophages
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Analysis of innate immune cells in proteasome subunit mutant mice2021
- Author(s)
  Hiroaki Hemmi, Takashi Orimo, Izumi Sasaki, Takashi Kato, Yuri Fukuda-Ohta, Noriko Kinjo, Hidenori Ohnishi, Nobuo Kanazawa, Tsuneyasu Kaisho
- Organizer
  16th Meeting of the International Endotoxin and Innate Immunity Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06956
[Presentation] Impaired development of myeloid cells in mice carrying a patient-derived proteasome subunit mutation.2020
- Author(s)
  邊見弘明、折茂貴是、佐々木泉、加藤喬、大田（福田）有里、金城紀子、浜田聡、木下晃、吉浦孝一郎、大西秀典、金澤伸雄、改正恒康
- Organizer
  第3回日本免疫不全・自己炎症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] 遺伝子改変マウスを用いた自己炎症性疾患病態解明へのアプローチ2020
- Author(s)
  邊見弘明
- Organizer
  愛媛大学プロテオサイエンスセンター（PROS）第８回学術シンポジウム難病のプロテオ医学研究2020 細胞死・炎症シグナル伝達機構の破綻による疾患と創薬２
- Invited
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] Cholera toxin B can induce interleukine-1β production in peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome.2019
- Author(s)
  Sasaki I, Orimo T, Hemmi H, Furukawa K, Kaisho T.
- Organizer
  The 26th International Symposium on Molecular Cell Biology of Macrophages.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] Generation and Analysis of Mice Carrying a Novel Heterozygous Missense Mutation of a Proteasome Subunit, PSMB9, in Patients with Autoinflammation and Immunodeficienty.2019
- Author(s)
  H. Hemmi, N. Kanazawa, N. Kinjo, S. Hamada, H. Ohnishi, T. Mizushima, A. Kinoshita, K.-I. Yoshiura, T. Kaisho.
- Organizer
  10th International congress 2019, Biannual Meeting of the International Society of Systemic Auto Inflammatory Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] コレラ毒素Bサブユニットは細胞内病原体センサーNLRP3とPyrinを介して炎症性サイトカインIL-1βの産生を誘導する2019
- Author(s)
  佐々木泉、折茂貴是、邊見弘明、古川鋼一、改正恒康
- Organizer
  第29回日本樹状細胞研究会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] Defective dendritic cell and monocyte development in proteasome subunit mutant mice.2019
- Author(s)
  Hemmi H, Orimo T, Sasaki I, Kato T, Fukuda-Ohta Y, Kinjo N, Hamada S, Kinoshita A, Yoshiura KI, Ohnishi H, Kanazawa N, Kaisho T.
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] Novel proteasome-related autoinflammation and immunodeficiency disease caused by a distinct heterozygous missense mutation in the PSMB9 gene.2019
- Author(s)
  Nobuo Kanazawa, Yumi Nakatani, Yutaka Inaba, Kayo Kunimoto, Noriko Kinjo, Satoru Hamada, Tsunehiro Mizushima, Akira Kinoshita, Koh-Ichiro Yoshiura, Jun Hamazaki, Shigeo Murata, Hidenori Ohnishi, Takashi Orimo, Hiroaki Hemmi, Tsuneyasu Kaisho.
- Organizer
  日本研究皮膚科学会　第44回年次学術大会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] Regulatory T cells with a distinctive feature expand through dermal dendritic cells in the ultraviolet B exposed skin.2019
- Author(s)
  Sayuri Yamazaki, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Hiroaki Hemmi, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita.
- Organizer
  16th International Workshop on Langerhans Cells
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] Roles of endoplasmic reticulum stress in cholera toxin B-induced interleukine-1β production from resident peritoneal macrophages.2019
- Author(s)
  Sasaki I, Morita S, Okuzaki D, Orimo T, Hemmi H, Furukawa K, Kaisho T.
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] コレラ毒素Bサブユニットによる炎症性サイトカインIL-1β産生誘導機構2019
- Author(s)
  佐々木泉、折茂貴是、邊見弘明、土屋慧馬、井上正一、熊谷直光、古川鋼一、改正恒康
- Organizer
  第26回日本免疫毒性学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] Dermal dendritic cells present neo-self antigens induced by ultraviolet B exposure to expand Foxp3+ regulatory T cells.2019
- Author(s)
  Sayuri Yamazaki, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Hiroaki Hemmi, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita.
- Organizer
  Society for Investigative Dermatology (SID) 77th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] Cholera toxin B can induce interleukine-1β production from resident per itoneal macrophages in synergy with lipopolysaccharides.2019
- Author(s)
  Sasaki I, Orimo T, Hemmi H, Furukawa K, Kaisho T.
- Organizer
  The 18th Awaji International Forum on Infection and Immunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] A Case of Neonatal-onset Proteasome-associated Autoinflammation and Immunodeficiency Disease Resembling but Distinct from Nakajo-Nishinura Syndrome.2019
- Author(s)
  N. Kinjo, S. Hamada, K. Nakanishi, H. Mishima, A. Kinoshita, K.-I. Yoshiura, T. Mizushima, J. Hamazaki, S. Murata, H. Hemmi, T. Kaisho, N. Kanazawa.
- Organizer
  10th International congress 2019, Biannual Meeting of the International Society of Systemic Auto Inflammatory Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] Analysis of mice carrying a novel and missense mutation of proteasome subunit gene identified in a patient with autoinflammation and immune deficiency.2019
- Author(s)
  Hiroaki Hemmi, Takashi Orimo, Naoko Nishiyama, Takashi Kato, Toshiya Ozasa, Izumi Sasaki, Noriko Kinjo, Nobuo Kanazawa, Tsuneyasu Kaisho.
- Organizer
  The 26th International Symposium on Molecular Cell Biology of Macrophages.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] ヒト疾患由来プロテアソームサブユニット突然変異導入マウスにおける樹状細胞分化障害2019
- Author(s)
  邊見弘明、小笹俊哉、加藤喬、折茂貴是、佐々木泉、大田（福田）有里、金澤伸雄、改正恒康.
- Organizer
  第29回日本樹状細胞研究会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] 生体内樹状細胞送達システムによる新規がんペプチドワクチン療法2018
- Author(s)
  水本有紀、勝田将裕、宮澤基樹、北畑裕司、宮本篤、中森幹人、尾島敏康、松田健司、邊見弘明、玉田耕治、改正恒康、山上裕機
- Organizer
  第39回癌免疫外科研究会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] 樹状細胞サブセットに注目したがんペプチドワクチン療法2018
- Author(s)
  水本有紀、勝田将裕、宮澤基樹、北畑裕司、宮本篤、中森幹人、松田健司、尾島敏康、邊見弘明、玉田耕治、改正恒康、山上裕機
- Organizer
  第77回日本癌学会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] A case of neonatal-onset proteasome-associated autoinflammatory syndrome resembling but distinct from Nakajo-Nishimura syndrome2018
- Author(s)
  Noriko Kinjo, Hiroyuki Mishima, Akira Kinoshita, Koh-Ichiro Yoshiura, Tsunehiro Mizushima, Jun Hamazaki, Shigeo Murata, Hiroaki Hemmi, Tsuneyasu Kaisho, Nobuo Kanazawa
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] A mouse model of LIG4 syndrome with novel LIG4 mutation2018
- Author(s)
  Yusuke Yamashita, Shinobu Tamura, Yuri Fukuda, Toshiya Ozasa, Nobuo Kanazawa, Hiroaki Hemmi, Koichiro Yoshiura, Tsuneyasu Kaisho, Takashi Sonoki
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] Analysis of mice carrying a novel mutation in a proteasome subunit gene identified in an autoinflammatory disease patient.2018
- Author(s)
  Toshiya Ozasa, Hiroaki Hemmi, Akira Kinoshita, Takashi Kato, Takashi Orimo, Izumi Sasaki, Yuri Fukuda-Ohta, Noriko Kinjo, Koh-Ichiro Yoshiura, Tsunehiro Mizushima, Nobuo Kanazawa, Tsuneyasu Kaisho
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] Impaired development of dendritic cells in proteasome subunit mutant mice2018
- Author(s)
  Hiroaki Hemmi, Toshiya Ozasa, Akira Kinoshita, Takashi Kato, Takashi Orimo, Izumi Sasaki, Yuri Fukuda-Ohta, Noriko Kinjo, Koh-Ichiro Yoshiura, Tsunehiro Mizushima, Nobuo Kanazawa, Tsuneyasu Kaisho
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] ケモカイン受容体XCR1陽性樹状細胞の機能的意義2018
- Author(s)
  邊見弘明、改正恒康
- Organizer
  第40回日本比較免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] 樹状細胞サブセットへの送達に注目したがんペプチドワクチン療法2018
- Author(s)
  水本有紀、勝田将裕、邊見弘明、宮澤基樹、北畑裕司、宮本篤、小林良平、中森幹人、尾島敏康、松田健司、中村公紀早田啓治、玉田耕治、改正恒康、山上裕機
- Organizer
  第31回日本バイオセラピィ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] Successful treatment of psoriatic inflammation restores hyperglycemia2018
- Author(s)
  Kyoko Ikumi, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Osamu Taguchi, Hiroaki Hemmi, Tsuneyasu Kaisho, Sayuri Yamazaki, Akimichi Morita
- Organizer
  International Investigative Dermatology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] 中條ー西村症候群からプロテアソーム関連自己炎症／免疫不全症候群へ2018
- Author(s)
  金澤伸雄、中谷友美、原知之、稲葉豊、国本佳代、古川福実、神人正寿、金城紀子、水島恒裕、三嶋博之、木下晃、吉浦孝一郎、邊見弘明、改正恒康
- Organizer
  第25回分子皮膚科学フォーラム
- Data Source
  KAKENHI-PROJECT-18K07071
[Presentation] Roles of arginine and methionine metabolism in cholera toxin-induced adjuvant effects.2017
- Author(s)
  Izumi Sasaki, Takashi Orimo, Hiroaki Hemmi, Toshiaki Ozasa, Yuri Fukuda, Shinji Fukuda, Tsuneyasu Kaisho.
- Organizer
  第46回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K08431
[Presentation] The critical role of dendritic cell subset in expanding Foxp3+ regulatory T cells in the murine skin after ultraviolet B exposure.2017
- Author(s)
  Sayuri Yamazaki, Akiko Nishioka, Saori Kasuya, Mizuyu Odanaka, Hiroaki Hemmi, Masaki Imai, Dieter Riethmacher, Tsuneyasu Kaisho, Naganari Ohkurah, Shimon Sakaguchi, Akimichi Morita.
- Organizer
  15th International Workshop on Langerhans Cells
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08431
[Presentation] Chemokine-directed cancer antigen peptide delivery to the XCR1+ dendritic cell subset.2016
- Author(s)
  Yuki Mizumoto, Hiroaki Hemmi, Masahiro Katsuda, Tomokazu Ohta, Yuri Fukuda, Atsushi Miyamoto, Hiroki Yamaue, Tsuneyasu Kaisho.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県那覇市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08431
[Presentation] Does Juzen-Taiho-To have immune-supressive effect?2016
- Author(s)
  Ken Kanno, Miziyu Odanaka, Masaki Imai, Akiko Nishioka, Mitsuhiko Nose, Hiroaki Hemmi, Tsuneyasu Kaisho, Akimichi orita, Sayuri Yamazaki.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県那覇市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08431
[Presentation] Metabolic basis for cholera toxin-induced IL-1beta production in synergy with lipopolysaccharides.2016
- Author(s)
  Izumi Sasaki, Shinji Fukuda, Takashi Orimo, Hiroaki Hemmi, Yuri Fukuda, Tomokazu Ohta, Kaisho Tsuneyasu.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県那覇市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08431
[Presentation] ケモカインXCL1を用いたがんペプチドワクチン療法の開発2016
- Author(s)
  水本有紀, 勝田将裕, 宮澤基樹, 北畑裕司, 宮本篤, 中森幹人, 松田健司, 尾島敏康, 早田啓治, 北谷純也, 邊見弘明, 改正恒康, 山上裕機.
- Organizer
  第29回日本バイオセラピィ学会学術集会総会
- Place of Presentation
  久留米シティプラザ（福岡県久留米市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K08431
[Presentation] Crosstalk between XCR1-expressing dendritic cells and intestinal T cells keeps intestinal homeostasis through the XCR1-XCL1 chemokine axis.2016
- Author(s)
  Tomokazu Ohta, Hiroaki Hemmi, Yuri Fukuda, Izumi Sasaki, Takashi Orimo, Tsuneyasu Kaisho.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県那覇市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08431
[Presentation] Role of the polyamine pathway in Cholera toxin-induced production of proinflammatory cytokines.2015
- Author(s)
  １４．Takashi Orimo, Izumi Sasaki, Shinji Fukuda, Hiroaki Hemmi, Yuri Fukuda. Tsuneyasu Kaisho.
- Organizer
  第４４回日本免疫学会総会
- Place of Presentation
  札幌コンベンションセンター（札幌）
- Year and Date
  2015-12-18
- Data Source
  KAKENHI-PROJECT-15K08431
[Presentation] Effective anti-tumor immunity provoked by chemokine-directed antigen delivering to a DC subset with high CTL-inducing ability.2015
- Author(s)
  Yuki Mizumoto, Hiroaki Hemmi, Masahiro Katsuda, Tomokazu Ohta, Yuri Fukida, Hiroki Yamaue, Tsuneyasu Kaisho.
- Organizer
  第４４回日本免疫学会総会
- Place of Presentation
  札幌コンベンションセンター（札幌）
- Year and Date
  2015-12-18
- Data Source
  KAKENHI-PROJECT-15K08431
[Presentation] Ultraviolet B-expanded thymus-derived Foxp3+ regulatory cells interact with dendritic cells in the skin.2015
- Author(s)
  Sayuri Yamazaki, Akiko Nishioka, Saori Kasuya, Naganari Ohkura, Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Taguchi, Shimon Sakaguchi, Akimichi Morita.
- Organizer
  14th International Workshop on Langerhans Cells
- Place of Presentation
  京都市国際交流協会（京都）
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08431
[Presentation] Intestinal immune homeostasis is regulated by XCR1-expressing dendritic cells through XCL1-XCR1 axis.2015
- Author(s)
  Tomokazu Ohta, Hiroaki Hemmi, Tsuneyasu Kaisho.
- Organizer
  14th International Workshop on Langerhans Cells
- Place of Presentation
  京都市国際交流協会（京都）
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08431
[Presentation] A novel mechanism to generate the intestinal intraepitherial T lymphocytes by XCR1-expressing dendritic cells2013
- Author(s)
  Ohta T, Hemmi H, Yamazaki C, Sugiyama M, Sasaki I, Hoshino K, Kaisho T.
- Organizer
  第42回　日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ（千葉県）
- Data Source
  KAKENHI-PROJECT-24590460
[Presentation] Function of XCR1-expressing dendritic cells in oral tolerance.2013
- Author(s)
  Hemmi H, Sugiyama M, Ohta T, Sasaki I, Yamazaki C, Tanaka T, Hoshino K, Kaisho T.
- Organizer
  第42回　日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ（千葉県）
- Data Source
  KAKENHI-PROJECT-24590460
[Presentation] Ablation of a dendritic cell subset expressing XC chemokine receptor 1 in vivo2012
- Author(s)
  Hemmi, H. et al.
- Organizer
  The 12th International Symposium on Dendritic Cells
- Place of Presentation
  EXCO （大邱, 韓国）
- Data Source
  KAKENHI-PROJECT-24590460
[Presentation] ケモカイン受容体Xcr1発現樹状細胞のin vivoにおける機能的意義2011
- Author(s)
  山崎千尋, 邊見弘明, 宮本理恵, 佐々木泉, 伊藤量基, 星野克明, 改正恒康
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22790376
[Presentation] CD8陽性樹状細胞の動的制御機構の解析2011
- Author(s)
  邊見弘明, 山崎千尋, 星野克明, 改正恒康
- Organizer
  第21回日本サイトメトリー学会学術集会
- Place of Presentation
  京都市国際会館
- Year and Date
  2011-06-26
- Data Source
  KAKENHI-PROJECT-22790376
[Presentation] マウス脾臓樹状細胞/マクロファージに発現しているTremファミリー分子Trem-like4の同定とその解析2009
- Author(s)
  邊見弘明, ほか
- Organizer
  第39回日本免疫学会学術集会・総会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20790299
[Presentation] マウス脾臓樹状細胞/マクロファージに発現しているTremファミリー分子Trem-like 4の同定とその解析2009
- Author(s)
  邊見弘明, Juliana Idoyaga, 高井俊行, 斉藤隆, 野田政樹, Ralph M. Steinman
- Organizer
  第39回日本免疫学会学術集会・総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790299
[Presentation] The identification and characterization of a new Trem-like Molecule2009
- Author(s)
  邊見弘明, et al.
- Organizer
  31st Annual Meeting of American Society of Bone and Mineral Research
- Place of Presentation
  Denver, CO, USA
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-20790299
[Presentation] The Identification and Characterization of A New Trem-like Molecule.2009
- Author(s)
  Hiroaki Hemmi, Juliana Idoyaga, Koji Suda, Masaki Noda, Ralph M. Steinman
- Organizer
  The 31st annual meeting of American Society for Bone and Mineral Research
- Place of Presentation
  Denver, CO, USA
- Data Source
  KAKENHI-PROJECT-20790299
[Presentation] Identification and characterization of a Trem-like molecule expressed on mouse splenic DCs and macrophages.2008
- Author(s)
  Hiroaki Hemmi, Juliana Idoyaga, Koji Suda, Nao Suda, Masaki Noda, Ralph M. Steinman
- Organizer
  The 10th International Symposium on Dendritic Cells
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20790299
[Presentation] Identification and characterization of a Trem-like molecule expressed on mouse splenic DCs and macrophages2008
- Author(s)
  H. Hemmi, et.al.
- Organizer
  The 10th International Symposium on Dendritic Cells
- Place of Presentation
  神戸国際会議場, 神戸
- Data Source
  KAKENHI-PROJECT-20790299
[Presentation] β-adrenergic Signaling Requires Bone Matrix Protein OOPN to Suppress Bone Formation and to Activate Bone Resorption.2007
- Author(s)
  M. Nagao, Y. Saita, J. Nagata, Y. Izu, T. Hayata, H. Hemmi, Y. Ezura, K. Nakashima, H. Kurosaws, M. Noda
- Organizer
  Twenty-Ninth Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  Hawaii Convention Center, Honolulu, HI, USA
- Year and Date
  2007-09-17
- Data Source
  KAKENHI-PROJECT-19890063
[Presentation] Osteoclast Specific Ablation of Dicer Suppresses Bone Resorption and Increases Bone Mass.2007
- Author(s)
  F. Mizoguchi, T. Nakamura, T. Hayata, H. Hemmi, Y. Ezura, K. Nakashima, N. Miyasaka, B. Harfe, S. Kato, M. Noda.
- Organizer
  Twenty-Ninth Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  Hawaii Convention Center, Honolulu, HI, USA
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-19890063
[Presentation] β2 Adrenergic Receptor Deficiency Enhances Bone Mass in by Antagonizing Against Aging-induced Bone Loss and Blunts Anabolic Effects of PTH on Osteoblasts.2007
- Author(s)
  R. Hanyu, Y. Saita, J. Nagata, Y. Izu, T. Hayata, H., Hemmi, S. Takeda, Y. Ezura, K. Nakashima, H. Kurosawa, M. Noda.
- Organizer
  Twenty-Ninth Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  Hawaii Convention Center, Honolulu, HI, USA
- Year and Date
  2007-09-16
- Data Source
  KAKENHI-PROJECT-19890063
[Presentation] Angiotensin II Suppresses Bone Mass via AT1 receptor in Long Bones of Adult Mice.2007
- Author(s)
  Y. Izu, T. Hayata, H. Hemmi, J. Nagata, Y. Ezura, K., Nakashima, M. Noda.
- Organizer
  Twenty-Ninth Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  Hawaii Convention Center, Honolulu, HI, USA
- Year and Date
  2007-09-17
- Data Source
  KAKENHI-PROJECT-19890063
[Presentation] Homeostasis of thymus-derived Foxp3+ regulatory T cells is controlled by ultraviolet B exposure in the skin.
- Author(s)
  Yamazaki S, Nishioka A, Kasuya K, Ohkura N, Hemmi H, Kaisho T, Taguchi O, Sakaguchi S, Morita A.
- Organizer
  第43回日本免疫学会総会・学術集会.
- Place of Presentation
  京都国際会館
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590460
[Presentation] Roles of Arginase I in Cholera toxin-induced production of proinflammatory cytokines.
- Author(s)
  Sasaki I, Fukuda S, Orimo T, Hemmi H, Kaisho T.
- Organizer
  第43回日本免疫学会総会・学術集会.
- Place of Presentation
  京都国際会館
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590460
[Presentation] XCL1 and XCR1 are involved in intestinal immune homeostasis by dendritic cells.
- Author(s)
  Ohta T, Okura S, Hemmi H, Sugiyama M, Sasaki I, Yamazaki C, Hoshino K, Kaisho T.
- Organizer
  第43回日本免疫学会総会・学術集会.
- Place of Presentation
  京都国際会館
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590460

1. Kunimoto Kayo (10438278)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 金澤伸雄 (90343227)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. FUKUDA Yuri

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. 稲葉豊 (00647571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TANAKA Yuriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. HATTORI Ikuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NISHIYAMA Naoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 改正恒康

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
9. 星野克明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 志馬寛明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 村嶋亜紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 濱崎純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HEMMI HIROAKI 邊見 弘明

HEMMI Hiroaki 邊見 弘明

Research Projects

Research Products

Co-Researchers

免疫プロテアソーム異常による疾患の病態と機能的意義の解明Principal Investigator

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Analysis of immunoproteasome function in immune cell developmentPrincipal Investigator

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Identification and analysis of novel inherited dysregulation of interferon

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Analysis of the immunoproteasome function in innate immunityPrincipal Investigator

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Elucidation of the pathological significance of a novel PSMB9 mutation in a sporadic case with Nakajo-Nishimura syndrome-like symptoms

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Analysis of dendritic cell functions in peripheral tissuesPrincipal Investigator

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Analysis of dendritic cell function in immune responsesPrincipal Investigator

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Functional analysis of Trem-like 4 in micePrincipal Investigator

Principal Investigator

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Functional analysis of a new Trem moleculePrincipal Investigator

Principal Investigator

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樹状細胞・マクロファージ等に発現している新規Trem分子の機能解析Principal Investigator

Principal Investigator

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Research Field

Research Institution

[Journal Article] Tmem45b is essential for inflammation- and tissue injury?induced mechanical pain hypersensitivity2022

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[Journal Article] Expression profile of immunoregulatory factors in canine tumors2022

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[Journal Article] Augmentation of STING‐induced type I interferon production in COPA syndrome2021

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HEMMI HIROAKI 邊見弘明

HEMMI Hiroaki 邊見弘明