Shimojo Masafumi 下條雅文

… Alternative Names

SHIMOJO MASAFUMI 下條雅文

Less

Researcher Number	20455348
Other IDs
Affiliation (Current)	2025: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究センター, 研究統括 2025: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究部, 研究統括
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究センター, 研究統括 2022 – 2023: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究部, 研究統括 2021: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究部, 主任研究員 2016 – 2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 研究員(任常)
Review Section/Research Field	Principal Investigator Basic Section 52040:Radiological sciences-related / Basic Section 51030:Pathophysiologic neuroscience-related / Transformative Research Areas, Section (III) / Biological Sciences / Radiation science
Keywords	Principal Investigator 生体脳イメージング / 蛍光 / PET / 炎症 / レポーター / 光イメージング / 認知症 / ポジトロン断層撮像法 / 広域顕微鏡 / 生体イメージング１ … More / 神経回路 / 多細胞 / 回路病態 / イメージング / 回路 / PETイメ―ジング / 回路再編 / 臨界期 / 非侵襲 / 生体深部イメージング / レポーター遺伝子 / 生体脳 / マルチモーダル / 生体深部 / バイオマーカー / AAV / 神経変性 / 神経炎症 / E/Iバランス / シナプス / トランスレーショナルリサーチ / 放射線 / 脳神経疾患 / 神経科学 / タウ / グルタミン酸受容体 / 診断法 Less

生体脳イメージングを基軸とした回路炎症病態の可視化と制御Principal Investigator
- Principal Investigator
  
  下條雅文
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Institutes for Quantum Science and Technology
炎症病態により誘導される回路再編メカニズムと遺伝学的制御Principal Investigator
- Principal Investigator
  
  下條雅文
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  National Institutes for Quantum Science and Technology
Imaging analysis of neuronal circuit for dissecting brain function and dysfunctionPrincipal Investigator
- Principal Investigator
  
  Shimojo Masafumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Development of imaging-based early diagnosis biomarkers of neurodegenerative disordersPrincipal Investigator
- Principal Investigator
  
  SHIMOJO MASAFUMI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
蛋白質と化合物の共進化により誘導される蛍光/PET脳機能イメージング技術Principal Investigator
- Principal Investigator
  
  下條雅文
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of PET imaging diagnostics to assess pathological cascade in Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  SHIMOJO MASAFUMI
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model.2023
- Author(s)
  Kudo T, Takuwa H, Takahashi M, Urushihata T, Shimojo M, Sampei K, Yamanaka M, Tomita Y, Sahara N, Suhara T, Higuchi M
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 4 Pages: 106342-106342
- DOI
  10.1016/j.isci.2023.106342
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06929, KAKENHI-PUBLICLY-21H05705, KAKENHI-PUBLICLY-21H00446, KAKENHI-PROJECT-23K21399, KAKENHI-PROJECT-21K07580
[Journal Article] Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy2022
- Author(s)
  Ono Maiko、Komatsu Masaaki、Ji Bin、Takado Yuhei、Shimojo Masafumi、Minamihisamatsu Takeharu、Warabi Eiji、Yanagawa Toru、Matsumoto Gen、Aoki Ichio、Kanaan Nicholas M.、Suhara Tetsuya、Sahara Naruhiko、Higuchi Makoto
- Journal Title
  
  Aging Cell
  
  Volume: 21 Issue: 7
- DOI
  10.1111/acel.13615
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-22K07529, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04771, KAKENHI-PLANNED-18H05414, KAKENHI-ORGANIZER-19H05705, KAKENHI-PLANNED-19H05706, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-22H04651, KAKENHI-PROJECT-23K24214
[Journal Article] A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model2022
- Author(s)
  Kimura Taeko、Ono Maiko、Seki Chie、Sampei Kazuaki、Shimojo Masafumi、Kawamura Kazunori、Zhang Ming-Rong、Sahara Naruhiko、Takado Yuhei、Higuchi Makoto
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 49 Issue: 13 Pages: 4298-4311
- DOI
  10.1007/s00259-022-05898-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-22K19393, KAKENHI-PUBLICLY-21H05705, KAKENHI-PUBLICLY-21H00446
[Journal Article] High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies2021
- Author(s)
  Tagai K, Ono M, Kubota M, Kitamura S, Takahata K, Seki C, Takado Y, Shinotoh H, Sano Y, Yamamoto Y, Matsuoka K, Takuwa H, Shimojo M, (24人省略), Shimada H.
- Journal Title
  
  Neuron
  
  Volume: 109 Issue: 1 Pages: 42-58
- DOI
  10.1016/j.neuron.2020.09.042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07543, KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-19K17101, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-18K07777, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-19H03362, KAKENHI-PROJECT-19H03583
[Journal Article] A first-in-human study of 11C-MTP38, a novel PET ligand for phosphodiesterase 72021
- Author(s)
  Kubota Manabu、Seki Chie、Kimura Yasuyuki、Takahata Keisuke、Shimada Hitoshi、Takado Yuhei、Matsuoka Kiwamu、Tagai Kenji、Sano Yasunori、Yamamoto Yasuharu、Okada Maki、Kikuchi Tatsuya、Ichise Masanori、Kawamura Kazunori、Zhang Ming-Rong、Higuchi Makoto
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 41 Issue: 11 Pages: 2928-2943
- DOI
  10.1177/0271678x211004150
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17101, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-20K07935, KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-23K21399
[Journal Article] A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains2021
- Author(s)
  Shimojo M、Ono M、Takuwa H、Mimura K、Nagai Y、Fujinaga M、Kikuchi T、Okada M、Seki C、Tokunaga M、Maeda J、Takado Y、Takahashi M、Minamihisamatsu T、Zhang M‐R、Tomita Y、Suzuki N、Maximov A、Suhara T、Minamimoto T、Sahara N、Higuchi M
- Journal Title
  
  The EMBO Journal
  
  Volume: 40 Issue: 22
- DOI
  10.15252/embj.2021107757
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-21K07580
[Journal Article] Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model2021
- Author(s)
  Sato H、Takado Y、Toyoda S、Tsukamoto-Yasui M、Minatohara K、Takuwa H、Urushihata T、Takahashi M、Shimojo M、Ono M、Maeda J、Orihara A、Sahara N、Aoki I、Karakawa S、Isokawa M、Kawasaki N、Kawasaki M、Ueno S、Kanda M、Nishimura M、Suzuki K、Mitsui A、Nagao K、Kitamura A、Higuchi M
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 43 Pages: 1-11
- DOI
  10.1126/sciadv.abd5046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K08005, KAKENHI-PROJECT-20K15910, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-23K21399
[Journal Article] MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice2021
- Author(s)
  Takado Yuhei、Takuwa Hiroyuki、Sampei Kazuaki、Urushihata Takuya、Takahashi Manami、Shimojo Masafumi、Uchida Shoko、Nitta Nobuhiro、Shibata Sayaka、Nagashima Keisuke、Ochi Yoshihiro、Ono Maiko、Maeda Jun、Tomita Yutaka、Sahara Naruhiko、Near Jamie、Aoki Ichio、Shibata Kazuhisa、Higuchi Makoto
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: 42 Issue: 1 Pages: 197-212
- DOI
  10.1177/0271678x211045449
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K08005, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-19H01041, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-23K21399
[Journal Article] Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor2021
- Author(s)
  93.Maeda J. Sahara N.（他１９名）
- Journal Title
  
  Brain Communications
  
  Volume: 3 Issue: 1 Pages: 1-19
- DOI
  10.1093/braincomms/fcab011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-18K07777, KAKENHI-PROJECT-19K16274, KAKENHI-PROJECT-16H06277
[Journal Article] Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.2020
- Author(s)
  Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, Aoki I, Kawamura K, Zhang MR, Suhara T, Sahara N, Higuchi M.
- Journal Title
  
  J Neurosci.
  
  Volume: 40 Issue: 17 Pages: 3491-3501
- DOI
  10.1523/jneurosci.2880-19.2020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-18K07777, KAKENHI-PROJECT-19K08005, KAKENHI-PUBLICLY-18H04752, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17K10387, KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-20K15910, KAKENHI-PUBLICLY-19H05437
[Journal Article] Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity2019
- Author(s)
  Shimojo Masafumi、Madara Joseph、Pankow Sandra、Liu Xinran、Yates John、S?dhof Thomas C.、Maximov Anton
- Journal Title
  
  Genes & Development
  
  Volume: 33 Issue: 5-6 Pages: 365-376
- DOI
  10.1101/gad.320077.118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07777, KAKENHI-PUBLICLY-18H04752
[Journal Article] In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg45102018
- Author(s)
  Ishikawa Ai、Tokunaga Masaki、Maeda Jun、Minamihisamatsu Takeharu、Shimojo Masafumi、Takuwa Hiroyuki、Ono Maiko、Ni Ruiqing、Hirano Shigeki、Kuwabara Satoshi、Ji Bin、Zhang Ming-Rong、Aoki Ichio、Suhara Tetsuya、Higuchi Makoto、Sahara Naruhiko
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 61 Issue: 3 Pages: 1037-1052
- DOI
  10.3233/jad-170509
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10387, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09979, KAKENHI-PROJECT-16K21636, KAKENHI-PROJECT-16K19872
[Journal Article] In Vivo Tau Imaging for a Diagnostic Platform of Tauopathy Using the rTg4510 Mouse Line2017
- Author(s)
  Sahara Naruhiko、Shimojo Masafumi、Ono Maiko、Takuwa Hiroyuki、Febo Marcelo、Higuchi Makoto、Suhara Tetsuya
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 8 Pages: 663-663
- DOI
  10.3389/fneur.2017.00663
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K21636
[Presentation] In vivo assessment of progressive astrogliosis in rTg4510 tauopathy animal brains2023
- Author(s)
  Shimojo Masafumi, Minamihisamatsu Takeharu, Takahiro Shimizu, Uchida Shoko, Takahashi Manami, Takuwa Hiroyuki, Matsushita Yumi, Yanai Rin, Minatohara Keiichiro, Zhang Ming-Rong, Sahara Naruhiko, Higuchi Makoto
- Organizer
  SfN2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07580
[Presentation] 脳疾患モデル動物を用いたPET画像解析2023
- Author(s)
  下條雅文
- Organizer
  第66回日本神経化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07580
[Presentation] In vivo assessment of progressive astrogliosis in rTg4510 tauopathy animal brains2023
- Author(s)
  Shimojo Masafumi, Minamihisamatsu Takeharu, Takahiro Shimizu, Uchida Shoko, Takahashi Manami, Takuwa Hiroyuki, Matsushita Yumi, Yanai Rin, Minatohara Keiichiro, Zhang Ming-Rong, Sahara Naruhiko, Higuchi Makoto
- Organizer
  第50回　内藤カンファレンス
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07580
[Presentation] Molecular profiles of inflammatory astrocyte in rTg4510 tauopathy animal brains2023
- Author(s)
  Shimojo Masafumi, Minamihisamatsu Takeharu, Takahiro Shimizu, Uchida Shoko, Takahashi Manami, Takuwa Hiroyuki, Matsushita Yumi, Yanai Rin, Minatohara Keiichiro, Zhang Ming-Rong, Sahara Naruhiko, Higuchi Makoto
- Organizer
  第46回日本神経科学会
- Data Source
  KAKENHI-PROJECT-21K07580
[Presentation] 脳深部回路を可視化するPETレポーターイメージング技術2022
- Author(s)
  下條　雅文
- Organizer
  第24回日本ヒト脳機能マッピング学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H05705
[Presentation] ecDHFRイメージング用の遺伝子レポーターPETトレーサー[18F]FHP-TMPの開発2022
- Author(s)
  大久保　崇之, 下條　雅文, 小野　麻衣子, 藤永　雅之, 小川　政直, 念垣　信樹, 永井　裕司, 南本　敬史, 樋口　真人, 張　明栄
- Organizer
  第62回日本核医学会学術総会
- Data Source
  KAKENHI-PUBLICLY-21H05705
[Presentation] In vivo assessment of progressive astrogliosis in the pathophysiological cascade of rTg4510 tauopathy animal brains2022
- Author(s)
  Shimojo Masafumi, Minamihisamatsu Takeharu, Manami Takahashi, Takuwa Hiroyuki, Matsushita Yumi, Yanai Rin, Keiichiro Minatohara, Zhang Ming-Rong, Sahara Naruhiko, Higuchi Makoto
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PUBLICLY-21H05705
[Presentation] In vivo assessment of progressive astrogliosis in the pathophysiological cascade of rTg4510 tauopathy animal brains2022
- Author(s)
  Shimojo Masafumi, Minamihisamatsu Takeharu, Manami Takahashi, Takuwa Hiroyuki, Matsushita Yumi, Yanai Rin, Keiichiro Minatohara, Zhang Ming-Rong, Sahara Naruhiko, Higuchi Makoto
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-21K07580
[Presentation] In vivo assessment of progressive astrogliosis in the pathophysiological cascade of rTg4510 tauopathy animal brains2022
- Author(s)
  Shimojo Masafumi, Minamihisamatsu Takeharu, Manami Takahashi, Takuwa Hiroyuki, Matsushita Yumi, Yanai Rin, Keiichiro Minatohara, Zhang Ming-Rong, Sahara Naruhiko, Higuchi Makoto
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K07580
[Presentation] In vivo assessment of progressive astrogliosis in the pathophysiological cascade of rTg4510 tauopathy animal brains2022
- Author(s)
  Shimojo Masafumi, Minamihisamatsu Takeharu, Manami Takahashi, Takuwa Hiroyuki, Matsushita Yumi, Yanai Rin, Keiichiro Minatohara, Zhang Ming-Rong, Sahara Naruhiko, Higuchi Makoto
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PUBLICLY-21H05705
[Presentation] 認知症モデル動物脳における炎症病態の画像解析2022
- Author(s)
  下條雅文
- Organizer
  タウ研究会2022
- Data Source
  KAKENHI-PUBLICLY-21H05705
[Presentation] 脳深部回路を可視化するPETレポーターイメージング技術2022
- Author(s)
  下條雅文
- Organizer
  第24回日本ヒト脳機能マッピング学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07580
[Presentation] 認知症モデル動物脳における炎症病態の画像解析2022
- Author(s)
  下條雅文
- Organizer
  タウ研究会2022
- Data Source
  KAKENHI-PROJECT-21K07580
[Presentation] ecDHFRイメージング用の遺伝子レポーターPETトレーサー[18F]FHP-TMPの開発2022
- Author(s)
  大久保　崇之, 下條　雅文, 小野　麻衣子, 藤永　雅之, 小川　政直, 念垣　信樹, 永井　裕司, 南本　敬史, 樋口　真人, 張　明栄
- Organizer
  第62回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07580
[Presentation] タウ病態モデルマウスにおける脳回路障害とその画像描出2021
- Author(s)
  下條雅文
- Organizer
  タウ研究会議
- Invited
- Data Source
  KAKENHI-PROJECT-21K07580
[Presentation] Genetically encoded reporter for PET monitoring of neuronal ensemble activities in the deep brain circuit2021
- Author(s)
  Shimojo Masafumi、Ono Maiko、Takuwa Hiroyuki、Mimura Koki、Nagai Yuji、Fujinaga Masayuki、Kikuchi Tatsuya、Okada Maki、Seki Chie、Tokunaga Masaki、Maeda Jun、Takado Yuhei、Takahashi Manami、Minamihisamatsu Takeharu、Zhang Ming‐Rong、Tomita Yutaka、Suzuki Norihiro、Maximov Anton、Higuchi Makoto
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-21K07580
[Presentation] Genetically targeted PET reporter imaging of deep neuronal circuit in the mammalian brain2021
- Author(s)
  Shimojo Masafumi、Ono Maiko、Takuwa Hiroyuki、Mimura Koki、Nagai Yuji、Fujinaga Masayuki、Kikuchi Tatsuya、Okada Maki、Seki Chie、Tokunaga Masaki、Maeda Jun、Takado Yuhei、Takahashi Manami、Minamihisamatsu Takeharu、Zhang Ming‐Rong、Tomita Yutaka、Suzuki Norihiro、Maximov Anton、Higuchi Makoto
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07580
[Presentation] Genetically encoded reporter for PET monitoring of neuronal ensemble activities in the deep brain circuit2021
- Author(s)
  Shimojo Masafumi、Ono Maiko、Takuwa Hiroyuki、Mimura Koki、Nagai Yuji、Fujinaga Masayuki、Kikuchi Tatsuya、Okada Maki、Seki Chie、Tokunaga Masaki、Maeda Jun、Takado Yuhei、Takahashi Manami、Minamihisamatsu Takeharu、Zhang Ming‐Rong、Tomita Yutaka、Suzuki Norihiro、Maximov Anton、Higuchi Makoto
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PUBLICLY-21H05705
[Presentation] Genetically targeted PET reporter imaging of deep neuronal circuit in the mammalian brain2021
- Author(s)
  Shimojo Masafumi、Ono Maiko、Takuwa Hiroyuki、Mimura Koki、Nagai Yuji、Fujinaga Masayuki、Kikuchi Tatsuya、Okada Maki、Seki Chie、Tokunaga Masaki、Maeda Jun、Takado Yuhei、Takahashi Manami、Minamihisamatsu Takeharu、Zhang Ming‐Rong、Tomita Yutaka、Suzuki Norihiro、Maximov Anton、Higuchi Makoto
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-21K07580
[Presentation] Genetically targeted PET reporter imaging of deep neuronal circuit in the mammalian brain2021
- Author(s)
  Shimojo Masafumi、Ono Maiko、Takuwa Hiroyuki、Mimura Koki、Nagai Yuji、Fujinaga Masayuki、Kikuchi Tatsuya、Okada Maki、Seki Chie、Tokunaga Masaki、Maeda Jun、Takado Yuhei、Takahashi Manami、Minamihisamatsu Takeharu、Zhang Ming‐Rong、Tomita Yutaka、Suzuki Norihiro、Maximov Anton、Higuchi Makoto
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-21H05705
[Presentation] タウ病態モデルマウスにおける脳回路障害とその画像描出2021
- Author(s)
  下條　雅文
- Organizer
  タウ研究会議
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H05705
[Presentation] Genetically encoded reporter for PET monitoring of neuronal ensemble activities in the deep brain circuit2021
- Author(s)
  Shimojo Masafumi、Ono Maiko、Takuwa Hiroyuki、Mimura Koki、Nagai Yuji、Fujinaga Masayuki、Kikuchi Tatsuya、Okada Maki、Seki Chie、Tokunaga Masaki、Maeda Jun、Takado Yuhei、Takahashi Manami、Minamihisamatsu Takeharu、Zhang Ming‐Rong、Tomita Yutaka、Suzuki Norihiro、Maximov Anton、Higuchi Makoto
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PUBLICLY-21H05705
[Presentation] Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.2020
- Author(s)
  Shimojo M
- Organizer
  日本神経化学会(WEB開催)
- Invited
- Data Source
  KAKENHI-PROJECT-18K07777
[Presentation] Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.2020
- Author(s)
  Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, Aoki I, Kawamura K, Zhang MR, Suhara T, Sahara N, *Higuchi M.
- Organizer
  日本神経科学会(WEB開催)
- Data Source
  KAKENHI-PROJECT-18K07777
[Presentation] Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.2020
- Author(s)
  Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, Aoki I, Kawamura K, Zhang MR, Suhara T, Sahara N, *Higuchi M.
- Organizer
  FENS Forum 2020 (Online)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07777
[Presentation] Genetically encoded reporter for bimodal optical and PET imaging in the mammalian brain2019
- Author(s)
  Shimojo M, Ono M, Takuwa H, Mimura K, Nagai Y, Fujinaga M, Kikuchi T, Okada M, Seki C, Tokunaga M, Maeda J, Takado Y, Takahashi M, Minamihisamatsu T, Zhang MR, Tomita Y, Suzuki N, Minamimoto T, Maximov A, Suhara T, Sahara N, Higuchi M
- Organizer
  Brain & BrainPET
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04752
[Presentation] Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity2019
- Author(s)
  Shimojo M, Madara J, Pankow S, Liu X, Yates J 3rd, Sudhof TC, Higuchi M, Maximov A
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PUBLICLY-18H04752
[Presentation] Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity2019
- Author(s)
  Shimojo M, Madara J, Pankow S, Liu X, Yates J 3rd, Sudhof TC, Higuchi M, Maximov A
- Organizer
  Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04752
[Presentation] Genetically encoded reporter for bimodal optical and PET imaging in the mammalian brain2019
- Author(s)
  Shimojo M, Ono M, Takuwa H, Mimura K, Nagai Y, Fujinaga M, Kikuchi T, Okada M, Seki C, Tokunaga M, Maeda J, Takado Y, Takahashi M, Minamihisamatsu T, Zhang MR, Tomita Y, Suzuki N, Minamimoto T, Maximov A, Suhara T, Sahara N, Higuchi M
- Organizer
  UK-Japan Neuroscience Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04752
[Presentation] Genetically encoded reporter for bimodal optical and PET imaging in the mammalian brain2018
- Author(s)
  Masafumi Shimojo, et al
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K07777
[Presentation] Genetically encoded reporter for bimodal optical and PET imaging in the mammalian brain2018
- Author(s)
  Masafumi Shimojo, et al
- Organizer
  SfN2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07777
[Presentation] In vivo assessment of synaptic properties in rTg4510 tauopathy transgenic mouse model by positron emission tomography2018
- Author(s)
  Masafumi Shimojo, Hiroyuki Takuwa, Yuhei Takado, Masaki Tokunaga, Urushihata Takuya, Tsukamoto Satoshi, Jun Maeda, Takeharu Minamihisamatsu, Ming-Rong Zhang, Ichio Aoki, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuchi
- Organizer
  第37回認知症学会
- Data Source
  KAKENHI-PUBLICLY-18H04752
[Presentation] In vivo assessment of synaptic properties in rTg4510 tauopathy transgenic mouse model by positron emission tomography2018
- Author(s)
  Masafumi Shimojo, Hiroyuki Takuwa, Yuhei Takado, Masaki Tokunaga, Urushihata Takuya, Tsukamoto Satoshi, Jun Maeda, Takeharu Minamihisamatsu, Ming-Rong Zhang, Ichio Aoki, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuchi
- Organizer
  第37回認知症学会
- Data Source
  KAKENHI-PROJECT-18K07777
[Presentation] Genetically encoded reporter for bimodal optical and PET imaging in the mammalian brain2018
- Author(s)
  Masafumi Shimojo, et al
- Organizer
  FENS Forum2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07777
[Presentation] Genetically encoded reporter for bimodal optical and PET imaging in the mammalian brain2018
- Author(s)
  Masafumi Shimojo, et al
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PUBLICLY-18H04752
[Presentation] Genetically encoded reporter for bimodal optical and PET imaging in the mammalian brain2018
- Author(s)
  Masafumi Shimojo, et al
- Organizer
  SfN2018
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04752
[Presentation] Genetically encoded reporter for bimodal optical and PET imaging in the mammalian brain2018
- Author(s)
  Masafumi Shimojo, et al
- Organizer
  FENS Forum2018
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04752
[Presentation] Multimodal imaging approach to dissect molecular and cellular mechanism of neuroscience2016
- Author(s)
  下條　雅文
- Organizer
  東京大学大学院医学系研究科セミナー
- Place of Presentation
  東京大学大学院 (東京)
- Year and Date
  2016-08-04
- Invited
- Data Source
  KAKENHI-PROJECT-16K21636
[Presentation] In vivo assessment of synaptic properties in rTg4510 tauopathy transgenic mouse model by positron emission tomography2016
- Author(s)
  Masafumi Shimojo, Masaki Tokunaga, Hiroyuki Takuwa, Yuhei Takado, Takeharu Minamihisamatsu, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi, Naruhiko Sahara
- Organizer
  SFN2016
- Place of Presentation
  San Diego (USA)
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21636

1. 小坂田文隆 (60455334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. SHIMADA Hitoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. TAKUWA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. TOMITA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 前田純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 樋口真人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 久保田学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 佐原成彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Shimojo Masafumi 下條 雅文

SHIMOJO MASAFUMI 下條 雅文

Research Projects

Research Products

Co-Researchers

生体脳イメージングを基軸とした回路炎症病態の可視化と制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

炎症病態により誘導される回路再編メカニズムと遺伝学的制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Imaging analysis of neuronal circuit for dissecting brain function and dysfunctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of imaging-based early diagnosis biomarkers of neurodegenerative disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

蛋白質と化合物の共進化により誘導される蛍光/PET脳機能イメージング技術Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of PET imaging diagnostics to assess pathological cascade in Alzheimer's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A first-in-human study of 11C-MTP38, a novel PET ligand for phosphodiesterase 72021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice2021

Author(s)

Journal Title

DOI

Shimojo Masafumi 下條雅文

SHIMOJO MASAFUMI 下條雅文