hoshii takayuki 星居孝之

… Alternative Names

Hoshii Takayuki 星居孝之

HOSHII Takayuki 星居孝之

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Researcher Number	20464042
Other IDs	https://orcid.org/0000-0002-5418-1981
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 千葉大学, 大学院医学研究院, 准教授 2019 – 2023: 千葉大学, 大学院医学研究院, 講師 2011 – 2014: 金沢大学, がん進展制御研究所, 助教 2010: 金沢大学, がん研究所, 助教
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 54010:Hematology and medical oncology-related / Hematology / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 白血病 / ヒストンメチル化 / 転写 / エピゲノム / mTOR / 細胞分化 / 転写伸長 / BuGZ / 休止解除 / ゲノム構造 … More / エピジェネティクス / 腫瘍抑制 / エンハンサー / 酵素活性 / 染色体分配 / 細胞分裂 / エピゲノム制御 / ヒストンメチル化酵素 / 転写制御 / 機能的重複 / エピゲノム修飾 / H3K4メチル化 / 酵素ドメイン / 重複性 / mTORC1 / 白血病幹細胞 / 自己複製 / 造血細胞 / mTOR複合体1 / mTOR複合体 / シグナル伝達 / 幹細胞 … More Except Principal Investigator ヒストン修飾 / 転写因子 / エピゲノム / 肝芽腫 Less

網羅的エピゲノム解析とゲノム編集技術を用いた肝芽腫の新規治療候補遺伝子の同定
- Principal Investigator
  
  工藤渉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Chiba University
Functional analysis of H3K4 methyltransferase activity for the epigenome replication in leukemiaPrincipal Investigator
- Principal Investigator
  
  星居孝之
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Comprehensive identification and functional analysis of anti-leukemogenic domains in enhancer regulatory moleculesPrincipal Investigator
- Principal Investigator
  
  星居孝之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Chiba University
Elucidation of the mechanism of AML progression through a genomic structure-dependent regulation of transcriptional elongationPrincipal Investigator
- Principal Investigator
  
  星居孝之
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Chiba University
Functional redundancy of H3K4 methyltransferase family on epigenetic regulation in leukemiaPrincipal Investigator
- Principal Investigator
  
  Hoshii Takayuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Chiba University
Elucidation of epigenomic regulation by chromosome segregation factor and identification of novel therapeutic target for leukemiaPrincipal Investigator
- Principal Investigator
  
  Hoshii Takayuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Chiba University
白血病クラスI変異による細胞分化異常におけるmTORC1活性の機能解析Principal Investigator
- Principal Investigator
  
  星居孝之
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University
Analysis for the role of mTORC1 in the self-renew of leukemia stem cellPrincipal Investigator
- Principal Investigator
  
  HOSHII Takayuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University
ｍＴＯＲ複合体１を介した細胞分化制御機構の解明Principal Investigator
- Principal Investigator
  
  星居孝之
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University
Research for regulatory mechanisms of normal hematopoietic stem cell and leukemia stem cell pool via mTOR Complex 1Principal Investigator
- Principal Investigator
  
  HOSHII Takayuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University

All 2023 2022 2021 2020 2019 2014 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] <scp>SETD1A</scp> function in leukemia is mediated through interaction with mitotic regulators <scp>BuGZ</scp>/<scp>BUB3</scp>2023
- Author(s)
  Perlee Sarah、Kikuchi Sota、Nakadai Tomoyoshi、Masuda Takeshi、Ohtsuki Sumio、Matsumoto Makoto、Rahmutulla Bahityar、Fukuyo Masaki、Cifani Paolo、Kentsis Alex、Roeder Robert G、Kaneda Atsushi、Hoshii Takayuki
- Journal Title
  
  EMBO reports
  
  Volume: 24 Issue: 10 Pages: 1-19
- DOI
  10.15252/embr.202357108
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07161, KAKENHI-PROJECT-22K07164, KAKENHI-PUBLICLY-22H05546, KAKENHI-PROJECT-23K23867, KAKENHI-PROJECT-23K24359
[Journal Article] SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia2022
- Author(s)
  Hoshii Takayuki、Perlee Sarah、Kikuchi Sota、Rahmutulla Bahityar、Fukuyo Masaki、Masuda Takeshi、Ohtsuki Sumio、Soga Tomoyoshi、Nabet Behnam、Kaneda Atsushi
- Journal Title
  
  Cell Reports
  
  Volume: 41 Issue: 9 Pages: 111727-111727
- DOI
  10.1016/j.celrep.2022.111727
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07164, KAKENHI-PUBLICLY-22H04684, KAKENHI-PROJECT-23K24359
[Journal Article] Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein‐Barr virus‐positive gastric cancer2021
- Author(s)
  Li Wenzhe、Okabe Atsushi、Usui Genki、Fukuyo Masaki、Matsusaka Keisuke、Rahmutulla Bahityar、Mano Yasunobu、Hoshii Takayuki、Funata Sayaka、Hiura Nobuhiro、Fukayama Masashi、Tan Patrick、Ushiku Tetsuo、Kaneda Atsushi
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 8 Pages: 3349-3362
- DOI
  10.1111/cas.14978
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07457, KAKENHI-PROJECT-19K16707, KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-19H03690
[Journal Article] Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma2020
- Author(s)
  Okabe Atsushi, Huang Kie Kyon, Matsusaka Keisuke, Fukuyo Masaki, Xing Manjie, Ong Xuewen, Hoshii Takayuki, Usui Genki, Seki Motoaki, Mano Yasunobu, Rahmutulla Bahityar, Kanda Teru, Suzuki Takayoshi, Rha Sun Young, Ushiku Tetsuo, Fukayama Masashi, Tan Patrick, Kaneda Atsushi
- Journal Title
  
  Nature Genetics
  
  Volume: 52 Issue: 9 Pages: 919-930
- DOI
  10.1038/s41588-020-0665-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07457, KAKENHI-PROJECT-19K09184, KAKENHI-PROJECT-19K16707, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H03690, KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-18J00861, KAKENHI-PROJECT-18K06983, KAKENHI-PROJECT-19K22399, KAKENHI-PROJECT-19K16101
[Journal Article] The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.2020
- Author(s)
  Naka K, Ochiai R, Matsubara E, Kondo C, Yang KM, Hoshii T, Araki M, Araki K, Sotomaru Y, Sasaki K, Mitani K, Kim D-W, Ooshima A, Kim SJ.
- Journal Title
  
  Nature Comm
  
  Volume: 11 Issue: 1 Pages: 4681-4681
- DOI
  10.1038/s41467-020-18491-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08822, KAKENHI-PROJECT-19H03690, KAKENHI-PROJECT-20H03517, KAKENHI-PROJECT-19H01056
[Journal Article] Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals.2014
- Author(s)
  Yamada D, Hoshii T, Tanaka S, Hegazy AM, Kobayashi M, Tadokoro Y, Ohta K, Ueno M, Ali MAE, Hirao A.
- Journal Title
  
  J Biochem.
  
  Volume: 155 Issue: 4 Pages: 227-33
- DOI
  10.1093/jb/mvt112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24790967, KAKENHI-PUBLICLY-25118710, KAKENHI-PUBLICLY-25130705, KAKENHI-PROJECT-25340028, KAKENHI-PROJECT-25461411, KAKENHI-PROJECT-25861263, KAKENHI-PROJECT-26460361
[Journal Article] Abundant nucleostemin expression supports the undifferentiated properties of germ cell tumors2013
- Author(s)
  Uema, N., Ooshio, T., Harada, K., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Ohta, K., Ali, M.A., Katano, M., Soga, T., Nakanuma, Y., Okuda, A., Hirao, A.
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 183 Issue: 2 Pages: 592-603
- DOI
  10.1016/j.ajpath.2013.04.018
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134007, KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24790967, KAKENHI-PUBLICLY-25118710, KAKENHI-PROJECT-25293082, KAKENHI-PROJECT-25461411, KAKENHI-PROJECT-25670147
[Journal Article] Metabolic regulation of osteoclast differentiation and function2013
- Author(s)
  Indo Y, Takeshita S, Ishii K, Hoshii T, Aburatani H, Hirao A, Ikeda K
- Journal Title
  
  J Bone Miner Res
  
  Volume: 28 Issue: 11 Pages: 2392-2399
- DOI
  10.1002/jbmr.1976
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22118007, KAKENHI-PROJECT-22390064, KAKENHI-PROJECT-22590330, KAKENHI-PROJECT-23659473, KAKENHI-PROJECT-24790967, KAKENHI-PUBLICLY-25118710
[Journal Article] Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.2013
- Author(s)
  Hoshii T, Kasada A, Hatakeyama T, Ohtani M, Tadokoro Y, Naka K, Ikenoue T, Ikawa T, Kawamoto H, Fehling HJ, Araki K, Yamamura K, Matsuda S, Hirao A
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 111 Issue: 10 Pages: 3805-3810
- DOI
  10.1073/pnas.1320265111
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22118004, KAKENHI-PROJECT-23310135, KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24249057, KAKENHI-PROJECT-24689042, KAKENHI-PROJECT-24790967, KAKENHI-PUBLICLY-25118710, KAKENHI-PUBLICLY-25118732, KAKENHI-PUBLICLY-25130705, KAKENHI-PROJECT-25460602, KAKENHI-PROJECT-25461411, KAKENHI-PROJECT-25670236, KAKENHI-PROJECT-25670447, KAKENHI-PROJECT-221S0001
[Journal Article] Mechanistic/mammalian target protein of rapamycin signaling in hematopoietic stem cells and leukemia.2013
- Author(s)
  Hirao A, Hoshii T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104 Issue: 8 Pages: 977-82
- DOI
  10.1111/cas.12189
- NAID
  120005830607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24790967
[Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.2013
- Author(s)
  Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
- Journal Title
  
  Mol Cell
  
  Volume: 51 Issue: 5 Pages: 618-631
- DOI
  10.1016/j.molcel.2013.08.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-23247034, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24790332, KAKENHI-PROJECT-24790967, KAKENHI-PLANNED-25111002, KAKENHI-PUBLICLY-25118710, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-25870631
[Journal Article] PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi-1 expression and nuclear translocation of RORγ2012
- Author(s)
  Kurebayashi Y. Nagai S. Ikejiri A. Ohtani M. Ichiyama K. Baba Y. Yamada T. Egami S. Hoshii T. Hirao A. Matsuda S. Koyasu S.
- Journal Title
  
  Cell Reports
  
  Volume: 1 Issue: 4 Pages: 360-373
- DOI
  10.1016/j.celrep.2012.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390290, KAKENHI-PROJECT-22229004, KAKENHI-PROJECT-22590439, KAKENHI-PROJECT-22790906, KAKENHI-PUBLICLY-23130507, KAKENHI-PROJECT-23390086, KAKENHI-PROJECT-23650593, KAKENHI-PROJECT-23790546, KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24790479, KAKENHI-PROJECT-24790967, KAKENHI-PUBLICLY-23118511
[Journal Article] Nucleostemin in injury-induced liver regeneration.2012
- Author(s)
  Shugo. H
- Journal Title
  
  Stem cells Dev.
  
  Volume: 21 Issue: 16 Pages: 3044-3054
- DOI
  10.1089/scd.2011.0725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J06332, KAKENHI-PROJECT-23659396, KAKENHI-PROJECT-23791076, KAKENHI-PROJECT-23791588, KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24790967, KAKENHI-PUBLICLY-23118511, KAKENHI-PUBLICLY-23130507
[Journal Article] mTORC1 is essential for leukemia-propagation but not stem cell self-renewal2012
- Author(s)
  Hoshii T
- Journal Title
  
  The Journal of Clinical Investigation
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790906
[Journal Article] mTORC1is essential for leukemia propagation but not stem cell self-renewal.2012
- Author(s)
  Hoshii. T
- Journal Title
  
  J Clin Invest.
  
  Volume: 122 Issue: 6 Pages: 2114-2129
- DOI
  10.1172/jci62279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J06332, KAKENHI-PROJECT-22790906, KAKENHI-PROJECT-23300159, KAKENHI-PROJECT-23310135, KAKENHI-PROJECT-23791076, KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24790967, KAKENHI-PLANNED-22134007, KAKENHI-PUBLICLY-23118511, KAKENHI-PUBLICLY-23130507, KAKENHI-PUBLICLY-23134507, KAKENHI-PUBLICLY-24115712
[Journal Article] mTORC1 is essential for leukemia-propagation but not stem cell self-renewal2012
- Author(s)
  Hoshii T
- Journal Title
  
  The Journal of Clinical Investigation
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23118511
[Journal Article] mTORC1 in Intestinal CD11c+CD11b+Dendritic Cells Regulates Intestinal Homeostasis by Promoting IL-10 Production2012
- Author(s)
  Ohtani M, Hoshii T, Fujii H, Koyasu S, Hirao A, Matsuda S.
- Journal Title
  
  J Immunol
  
  Volume: 188 Issue: 10 Pages: 4736-40
- DOI
  10.4049/jimmunol.1200069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390290, KAKENHI-PROJECT-22229004, KAKENHI-PROJECT-22590437, KAKENHI-PROJECT-22590439, KAKENHI-PROJECT-22790906, KAKENHI-PUBLICLY-23118511, KAKENHI-PUBLICLY-23130507, KAKENHI-PROJECT-23650593, KAKENHI-PROJECT-23790546, KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24790967
[Journal Article] Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells.2011
- Author(s)
  Naka K, Hoshii T, Hirao A.
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 1577-1581
- NAID
  10026594276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790906
[Journal Article] NKX2. 2 suppresses self-renewal of glioma-initiating cells2011
- Author(s)
  Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii H, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J
- Journal Title
  
  Cancer Res
  
  Volume: 71 Issue: 3 Pages: 1135-45
- DOI
  10.1158/0008-5472.can-10-2304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390290, KAKENHI-PROJECT-21390404, KAKENHI-PROJECT-21591864, KAKENHI-PROJECT-22790906
[Journal Article] NKX2.2 suppresses self-renewal of glioma-initiating cells.2011
- Author(s)
  Muraguchi T, Hoshii T.Hirao A
- Journal Title
  
  Cancer Res
  
  Volume: 71 Pages: 1135-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790906
[Journal Article] Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells2010
- Author(s)
  Naka K, Hoshii T, Hirao A.
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Issue: 7 Pages: 1577-81
- DOI
  10.1111/j.1349-7006.2010.01584.x
- NAID
  10026594276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390290, KAKENHI-PROJECT-22790906
[Presentation] BOD1L facilitates chromatin binding of SETD1A and promotes leukemia cell growth2023
- Author(s)
  星居孝之
- Organizer
  第16回エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-23K24359
[Presentation] BOD1L facilitates chromatin binding of SETD1A and promotes leukemia cell growth2023
- Author(s)
  星居孝之
- Organizer
  The 2nd International Symposium on REPLICATION of NON GENOME
- Data Source
  KAKENHI-PROJECT-23K24359
[Presentation] 統合解析による肝芽腫の生存・増殖に重要な転写因子の同定2023
- Author(s)
  工藤渉, 星居孝之, 関元昭, 岡部篤史, 福世真樹,バハテヤリラヒムトラ, 菱木知郎,金田篤志
- Organizer
  第65回日本小児血液・がん学会
- Data Source
  KAKENHI-PROJECT-23K07245
[Presentation] Identifying key transcription factors to survival and growth in hepatoblastoma by integrated analysis2023
- Author(s)
  工藤渉, 星居孝之, 関元昭, 岡部篤史, 福世真樹,バハテヤリラヒムトラ, 菱木知郎,金田篤志
- Organizer
  第82回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07245
[Presentation] BOD1L facilitates chromatin binding of SETD1A and promotes leukemia cell growth2023
- Author(s)
  星居孝之
- Organizer
  ASH ANNUAL Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24359
[Presentation] SETD1A function is mediated through interaction with mitotic regulators BuGZ/BUB3 in leukemia2023
- Author(s)
  星居孝之
- Organizer
  ISEH 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24359
[Presentation] SETD1A regulates transcriptional pause release of heme biosynthesis genes in acute myeloid leukemia2022
- Author(s)
  星居孝之
- Organizer
  第15回エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-23K24359
[Presentation] SETD1A regulates transcriptional pause release of heme biosynthesis genes in acute myeloid leukemia2022
- Author(s)
  星居孝之
- Organizer
  第15回エピジェネティクス研究会
- Data Source
  KAKENHI-PUBLICLY-22H04684
[Presentation] SETD1A regulates transcriptional pause release of heme biosynthesis genes in acute myeloid leukemia2022
- Author(s)
  星居孝之
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24359
[Presentation] Functional specificity and redundancy of H3K4 HMTs in leukemia2022
- Author(s)
  星居孝之
- Organizer
  2023 Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24359
[Presentation] Functional specificity and redundancy of H3K4 HMTs in leukemia2022
- Author(s)
  星居孝之
- Organizer
  2023 Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19538
[Presentation] H3K4メチル化酵素活性による白血病非ゲノム情報複製機構の解明2022
- Author(s)
  星居孝之
- Organizer
  第５回新学術領域「非ゲノム情報複製機構」領域会議
- Data Source
  KAKENHI-PUBLICLY-22H04684
[Presentation] SETD1A regulates transcriptional pause release of heme biosynthesis genes in acute myeloid leukemia2022
- Author(s)
  星居孝之
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PUBLICLY-22H04684
[Presentation] Functional specificity and redundancy of H3K4 HMTs in leukemia2022
- Author(s)
  星居孝之
- Organizer
  2023 Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04684
[Presentation] H3K4 methyltransferase SETD1A regulates the mitochondrial respiration in acute myeloid leukemia2021
- Author(s)
  星居孝之
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03690
[Presentation] 新規H3K4メチル化複合体による細胞周期に伴うDNA損傷応答機構の制御2020
- Author(s)
  星居孝之
- Organizer
  第14回日本エピジェネティクス研究会（招待講演）
- Invited
- Data Source
  KAKENHI-PROJECT-19H03690
[Presentation] Roles of non-canonical H3K4 methyltransferase complex in leukemia2020
- Author(s)
  星居孝之
- Organizer
  The 7th Cancer Epigenomics Symposium
- Data Source
  KAKENHI-PROJECT-19H03690
[Presentation] Roles of non-canonical H3K4 methyltransferase complex in leukemia2020
- Author(s)
  星居孝之
- Organizer
  The 7th Cancer Epigenomics Symposium
- Data Source
  KAKENHI-PROJECT-19K22399
[Presentation] 新規H3K4メチル化複合体による細胞周期に伴うDNA損傷応答機構の制御2020
- Author(s)
  星居孝之
- Organizer
  第14回日本エピジェネティクス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22399
[Presentation] H3K4メチル基転移酵素の触媒作用非依存的な転写制御2019
- Author(s)
  星居孝之
- Organizer
  第13回日本エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-19H03690
[Presentation] H3K4メチル基転移酵素の触媒作用非依存的な転写制御2019
- Author(s)
  星居孝之
- Organizer
  第13回日本エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-19K22399
[Presentation] Targeting of a non-catalytic function of H3K4 methyltransferase SETD1A in leukemia2019
- Author(s)
  星居孝之
- Organizer
  第78回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22399
[Presentation] Targeting of a non-catalytic function of H3K4 methyltransferase SETD1A in leukemia2019
- Author(s)
  星居孝之
- Organizer
  第78回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03690
[Presentation] H3K4メチル化酵素の触媒活性非依存的な転写調節による白血病細胞の増殖制御2019
- Author(s)
  星居孝之
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03690
[Presentation] H3K4メチル化酵素の触媒活性非依存的な転写調節による白血病細胞の増殖制御2019
- Author(s)
  星居孝之
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22399
[Presentation] mTORC1 is essential for propagation of earliest T lineage-committed cell in normal lymphopoiesis and leukemogenesis2013
- Author(s)
  星居孝之、笠田篤郎、平尾敦
- Organizer
  第11回幹細胞シンポジウム
- Place of Presentation
  東京大学伊藤国際学術センター（東京都）
- Data Source
  KAKENHI-PUBLICLY-25118710
[Presentation] mTORC1 is essential for T lineage-committed cell in normal lymphopoiesis and leukemogenesis2013
- Author(s)
  星居孝之、笠田篤郎、大谷真志、池上恒雄、伊川友活、河本宏、荒木喜美、山村研一、松田達志、平尾敦
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  さっぽろ芸文館・ロイトン札幌・札幌市教育分化会館（北海道）
- Data Source
  KAKENHI-PUBLICLY-25118710
[Presentation] mTORC1 inactivation prevents and eradicates acute lymphoblastic T-cell leukemia2013
- Author(s)
  Takayuki Hoshii, Atuo Kasada, Tomoki Hatakeyama, Masashi Ohtani, Yuko Tadokoro, Kazuhito Naka, Tsuneo Ikenoue, Tomokatsu Ikawa, Hiroshi Kawamoto, Asushi Iwama, Kimi Araki, Ken-ichi Yamamura, Satoshi Matsuda, Atsushi Hirao
- Organizer
  2013 ASH annual meeting and exposition, New Orleans
- Place of Presentation
  LA (USA)
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] T 細胞発生と急性T リンパ性白血病におけるmTORC1 の機能解析2013
- Author(s)
  星居孝之
- Organizer
  平成25年度がん若手研究者ワークショップ
- Place of Presentation
  蓼科グランドホテル滝の湯(長野県)
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] mTORC1 is essential for T lineage-committed cell in normal lymphopoiesis and leukemogenesis2013
- Author(s)
  星居孝之、笠田篤郎、大谷真志、池上恒雄、伊川友活、河本宏、荒木喜美、山村研一、松田達志、平尾敦
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  さっぽろ芸文館・ロイトン札幌・札幌市教育分化会館（北海道）
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] T細胞発生と急性Tリンパ性白血病におけるmTORC1の機能解析2013
- Author(s)
  星居孝之
- Organizer
  平成25年度がん若手研究者ワークショップ
- Place of Presentation
  蓼科グランドホテル滝の湯（長野県）
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] mTORC1 inactivation prevents and eradicates acute lymphoblastic T-cell leukemia2013
- Author(s)
  Takayuki Hoshii, Atuo Kasada, Tomoki Hatakeyama, Masashi Ohtani, Yuko Tadokoro, Kazuhito Naka, Tsuneo Ikenoue, Tomokatsu Ikawa, Hiroshi Kawamoto, Asushi Iwama, Kimi Araki, Ken-ichi Yamamura, Satoshi Matsuda, Atsushi Hirao
- Organizer
  2013 ASH annual meeting and exposition
- Place of Presentation
  New Orleans, LA (USA)
- Data Source
  KAKENHI-PUBLICLY-25118710
[Presentation] mTORC1 inactivation prevents and eradicates acute lymphoblastic T-cell leukemia2013
- Author(s)
  Takayuki Hoshii, Atuo Kasada, Tomoki Hatakeyama, Masashi Ohtani, Yuko Tadokoro, Kazuhito Naka, Tsuneo Ikenoue, Tomokatsu Ikawa, Hiroshi Kawamoto, Asushi Iwama, Kimi Araki, Ken-ichi Yamamura, Satoshi Matsuda, Atsushi Hirao
- Organizer
  2013 ASH annual meeting and exposition
- Place of Presentation
  New Orleans, LA (USA)
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] mTORC1 is essential for T lineage-committed cell in normal lymphopoiesis and leukemogenesis2013
- Author(s)
  星居孝之, 笠田篤郎, 大谷真志, 池上恒雄, 伊川友活, 河本宏, 荒木喜美, 山村研一, 松田達志, 平尾敦
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  さっぽろ芸文館・ロイトン札幌・札幌市教育分化会館(北海道)
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] 白血病クラスI変異による細胞分化異常におけるmTORC1 活性の機能解析2013
- Author(s)
  星居孝之
- Organizer
  新学術領域研究「細胞運命制御」
- Place of Presentation
  グランドエクシブ鳴門(徳島県)
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] T細胞発生と急性Tリンパ性白血病におけるmTORC1の機能解析2013
- Author(s)
  星居孝之
- Organizer
  平成25年度がん若手研究者ワークショップ
- Place of Presentation
  蓼科グランドホテル滝の湯（長野県）
- Data Source
  KAKENHI-PUBLICLY-25118710
[Presentation] mTORC1 is essential for propagation of earliest T lineage-committed cell in normal lymphopoiesis and leukemogenesis2013
- Author(s)
  星居孝之, 笠田篤郎, 平尾敦
- Organizer
  第11回幹細胞シンポジウム
- Place of Presentation
  東京大学伊藤国際学術センター(東京都)
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] mTORC1 is essential for propagation of earliest T lineage-committed cell in normal lymphopoiesis and leukemogenesis2013
- Author(s)
  星居孝之、笠田篤郎、平尾敦
- Organizer
  第11回幹細胞シンポジウム
- Place of Presentation
  東京大学伊藤国際学術センター（東京都）
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] 活性型K-Ras 変異による白血病発症におけるmTOR 複合体1 の役割2013
- Author(s)
  星居孝之
- Organizer
  第17回造血器腫瘍研究会
- Place of Presentation
  シーガイア・コンベンションセンター(宮崎県)
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] 急性骨髄性白血病細胞の増殖と幹細胞維持におけるmTORC1の機能解析2012
- Author(s)
  星居孝之
- Organizer
  第16回造血器腫瘍研究会
- Place of Presentation
  国立がん研究センター(東京都)
- Data Source
  KAKENHI-PROJECT-22790906
[Presentation] Acute myeloid leukemia stem cells lacking Raptor self-renew but have defective leukemia initiating capacity in mice2012
- Author(s)
  星居孝之, 田所優子, 仲一仁, 大塩貴子, 村口輝之, 杉山直幸, 曽我朋義, 荒木喜美, 山村研一, 平尾敦
- Organizer
  International Society for Stem Cell Research (ISSCR) 10th Annual Meeting
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] 急性骨髄性白血病細胞の増殖と幹細胞維持におけるmTOR複合体1(mTORC1)の機能解析2012
- Author(s)
  星居孝之
- Organizer
  新学術領域「細胞運命制御」若手の会
- Place of Presentation
  軽井沢プリンスホテル(長野県)
- Data Source
  KAKENHI-PROJECT-22790906
[Presentation] Acute myeloid leukemia stem cells lacking mTORC1 self-renew but have defective leukemia-initiating capacity in mice2012
- Author(s)
  星居孝之, 仲一仁, 村口輝行, 曽我朋義, 荒木喜美, 山村研一, 平尾敦
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌・さっぽろ芸文館・札幌市教育分化会館(北海道)
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] Acute myeloid leukemia stem cells lacking mTORC1 self-renew but have defective leukemia-initiating capacity in mice2012
- Author(s)
  星居孝之
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌・さっぽろ芸文館・札幌市教育文化会館（北海道）
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PUBLICLY-23118511
[Presentation] AML stem cells lacking mTORC1 self-renew but have defective leukemia-initiating capacity in mice2012
- Author(s)
  星居孝之
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館（京都府）
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] 急性骨髄性白血病細胞の増殖と幹細胞維持におけるmTORC1の機能解析2012
- Author(s)
  星居孝之
- Organizer
  第16回造血器腫瘍研究会
- Place of Presentation
  国立がん研究センター(東京都)
- Year and Date
  2012-01-29
- Data Source
  KAKENHI-PUBLICLY-23118511
[Presentation] AML stem cells lacking mTORC1 self-renew but have defective leukemia-initiating capacity in mice2012
- Author(s)
  星居孝之, 田所優子, 仲一仁, 大塩貴子, 村口輝之, 杉山直幸, 曽我朋義, 荒木喜美, 山村研一, 平尾敦
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] Analysis of survival signals in mTORC1-deficient acute myeloid leukemia stem cells2012
- Author(s)
  星居孝之
- Organizer
  International symposium on genetic and epigenetic control of cell fate
- Place of Presentation
  グランドプリンスホテル京都（京都府）
- Year and Date
  2012-11-06
- Data Source
  KAKENHI-PUBLICLY-23118511
[Presentation] Acute myeloid leukemia stem cells lacking Raptor self-renew but have defective leukemia initiating capacity in mice2012
- Author(s)
  星居孝之
- Organizer
  International Society for Stem Cell Research (ISSCR) 10th Annual Meeting
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] mTORC1シグナルによる造血細胞の増殖・分化制御2012
- Author(s)
  星居孝之
- Organizer
  新学術領域研究「細胞運命制御」
- Place of Presentation
  グランドプリンスホテル（広島県）
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] mTORC1シグナルによる造血細胞の増殖・分化制御2012
- Author(s)
  星居孝之
- Organizer
  新学術領域研究「細胞運命制御」
- Place of Presentation
  グランドプリンスホテル（広島県）
- Year and Date
  2012-06-05
- Data Source
  KAKENHI-PUBLICLY-23118511
[Presentation] Analysis of survival signals in mTORC1-deficient acute myeloid leukemia stem cells2012
- Author(s)
  Hoshii T, Hirao A
- Organizer
  International symposium on genetic and epigenetic control of cell fate
- Place of Presentation
  グランドプリンスホテル京都(京都府)
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] Analysis of survival signals in mTORC1-deficient acute myeloid leukemia stem cells2012
- Author(s)
  星居孝之
- Organizer
  International symposium on genetic and epigenetic control of cell fate
- Place of Presentation
  グランドプリンスホテル京都（京都府）
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] AML stem cells lacking mTORC1 self-renew but have defective leukemia-initiating capacity in mice2012
- Author(s)
  星居孝之
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館（京都府）
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PUBLICLY-23118511
[Presentation] Acute myeloid leukemia stem cells lacking mTORC1 self-renew but have defective leukemia-initiating capacity in mice2012
- Author(s)
  星居孝之
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌・さっぽろ芸文館・札幌市教育分化会館（北海道）
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] mTORC1 シグナルによる造血細胞の増殖・分化制御2012
- Author(s)
  星居孝之
- Organizer
  新学術領域研究「細胞運命制御」
- Place of Presentation
  グランドプリンスホテル広島(広島県)
- Data Source
  KAKENHI-PROJECT-24790967
[Presentation] Acute myeloid leukemia stem cells lacking Raptor self-renew but have defective leukemia initiating capacity in mice2012
- Author(s)
  星居孝之
- Organizer
  International Society for Stem Cell Research (ISSCR) 10th Annual Meeting
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2012-06-13
- Data Source
  KAKENHI-PUBLICLY-23118511
[Presentation] 急性骨髄性白血病細胞の増殖と幹細胞維持におけるmTORC1の機能解析2011
- Author(s)
  星居孝之
- Organizer
  新学術領域研究「細胞運命制御」若手の会
- Place of Presentation
  軽井沢プリンスホテル西館(長野県)
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PUBLICLY-23118511
[Presentation] Rapamycin inhibits initiation of T-ALL induced by activation of oncogenic K-ras2011
- Author(s)
  星居孝之
- Organizer
  第11回日本分子生物学会春季シンポジウム
- Place of Presentation
  石川県立音楽堂(石川県)
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-22790906
[Presentation] Roles of mTORC1 signaling innormal hematopoiesis andleukemogenesis2011
- Author(s)
  星居孝之
- Organizer
  日米血液腫瘍セミナー
- Place of Presentation
  湘南国際村センター(神奈川県)
- Data Source
  KAKENHI-PROJECT-22790906
[Presentation] Rapamycin inhibits initiation of T-ALL induced by activation of oncogenic K-ras2011
- Author(s)
  星居孝之
- Organizer
  第11回日本分子生物学会春季シンポジウム
- Place of Presentation
  石川県立音楽堂(石川県)
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PUBLICLY-23118511
[Presentation] TSC-mTOR signaling controlsthe hematopoietic stem cell pool2010
- Author(s)
  星居孝之
- Organizer
  日本分子生物学会第10回春季シンポジウム
- Place of Presentation
  ホテル松島大観荘(宮城県)
- Year and Date
  2010-06-07
- Data Source
  KAKENHI-PROJECT-22790906
[Presentation] Strict regulation mTOR signaling is essential for hematopoietic stem cell maintenance in vivo2010
- Author(s)
  星居孝之
- Organizer
  第8回幹細胞シンポジウム
- Place of Presentation
  淡路国際夢舞台(兵庫)
- Year and Date
  2010-05-15
- Data Source
  KAKENHI-PROJECT-22790906
[Presentation] Strict regulation of mTOR signaling is essential for hematopoietic stem cell maintenancein vivo2010
- Author(s)
  星居孝之
- Organizer
  第8回幹細胞シンポジウム
- Place of Presentation
  淡路夢舞台(兵庫県)
- Year and Date
  2010-05-15
- Data Source
  KAKENHI-PROJECT-22790906
[Presentation] Rapamycin inhibits initiation of T-ALL induced by activation of oncogenic K-ras2010
- Author(s)
  星居孝之
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22790906

1. 金田篤志 (10313024)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. 荒木喜美 (90211705)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 武藤朋也 (90723560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 増田豪 (70383940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 工藤渉 (10928047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 菱木知郎 (00375776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 岡部篤史 (80778118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. FUKUYO Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. MATSUSAKA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 曽我朋義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 平尾敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
12. 池田恭治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 竹下淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 河本宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 三谷絹子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 佐々木光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 田中啓二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 中太智義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

hoshii takayuki 星居 孝之

Hoshii Takayuki 星居 孝之

HOSHII Takayuki 星居 孝之

Research Projects

Research Products

Co-Researchers

網羅的エピゲノム解析とゲノム編集技術を用いた肝芽腫の新規治療候補遺伝子の同定

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Functional analysis of H3K4 methyltransferase activity for the epigenome replication in leukemiaPrincipal Investigator

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Comprehensive identification and functional analysis of anti-leukemogenic domains in enhancer regulatory moleculesPrincipal Investigator

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Elucidation of the mechanism of AML progression through a genomic structure-dependent regulation of transcriptional elongationPrincipal Investigator

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Functional redundancy of H3K4 methyltransferase family on epigenetic regulation in leukemiaPrincipal Investigator

Principal Investigator

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Elucidation of epigenomic regulation by chromosome segregation factor and identification of novel therapeutic target for leukemiaPrincipal Investigator

Principal Investigator

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白血病クラスI変異による細胞分化異常におけるmTORC1活性の機能解析Principal Investigator

Principal Investigator

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Review Section

Research Institution

Analysis for the role of mTORC1 in the self-renew of leukemia stem cellPrincipal Investigator

Principal Investigator

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ｍＴＯＲ複合体１を介した細胞分化制御機構の解明Principal Investigator

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Research Institution

Research for regulatory mechanisms of normal hematopoietic stem cell and leukemia stem cell pool via mTOR Complex 1Principal Investigator

Principal Investigator

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Research Institution

[Journal Article] <scp>SETD1A</scp> function in leukemia is mediated through interaction with mitotic regulators <scp>BuGZ</scp>/<scp>BUB3</scp>2023

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[Journal Article] SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia2022

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[Journal Article] Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein‐Barr virus‐positive gastric cancer2021

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hoshii takayuki 星居孝之

Hoshii Takayuki 星居孝之

HOSHII Takayuki 星居孝之