AKUTA Norio 芥田憲夫

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芥田憲夫アクタノリオ

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Researcher Number	20469638
Affiliation (Current)	2025: (財)冲中記念成人病研究所, その他部局等, 研究員
Affiliation (based on the past Project Information) *help	2011: 公益財団法人冲中記念成人病研究所, 研究員 2010 – 2011: 財団法人冲中記念成人病研究所, 研究員 2009: Japan Society for the Promotion of Science, 研究員
Review Section/Research Field	Principal Investigator Gastroenterology
Keywords	Principal Investigator HOMA-IR / インスリン抵抗性 / 糖代謝 / NS5A-ISDR / 脂質代謝 / 肝発癌 / Ribavirin / Peginterferon / Coreアミノ酸置換 / HCV / 肝臓学

Clinical significance of HCV core region, to antiviral therapy and clinicopatological features.Principal Investigator
- Principal Investigator
  
  AKUTA Norio
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Okinaka Memorial Institute for Medical Research

All 2012 2011 2010 2009 2007 2005

All Journal Article Presentation Patent

[Journal Article] Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variati on Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy2012
- Author(s)
  Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H
- Journal Title
  
  Intervirology
  
  Volume: 55 Issue: 3 Pages: 231-41
- DOI
  10.1159/000328327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-21590866, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24659368
[Journal Article] Amino acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment efficacy to interferon plus ribavirin combination therapy2012
- Author(s)
  Akuta N, Kumada H(他13名, 1番目)
- Journal Title
  
  Intervirology
  
  Volume: 55 Pages: 231-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590866
[Journal Article] Amino acid substitutions in hepatitis C virus core region predict hepatocarcinogenesis following eradication of HCV RNA by antiviral therapy2011
- Author(s)
  芥田憲夫
- Journal Title
  
  Journal of Medical Virology
  
  Volume: VOL.83 Issue: 6 Pages: 1016-1022
- DOI
  10.1002/jmv.22094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590866
[Journal Article] Amino acid substitutions in hepatitis C virus core region predict hepatocarcinogenesis following eradication of HCV RNA by antiviral therapy2011
- Author(s)
  Akuta N, Kumada H(他11名, 1番目)
- Journal Title
  
  J Med Virol
  
  Volume: 83 Pages: 1016-1022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590866
[Journal Article] Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin2010
- Author(s)
  Akuta N, Kumada H(他14名, 1番目)
- Journal Title
  
  Hepatology
  
  Volume: 52 Pages: 412-429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590866
[Journal Article] Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin.2010
- Author(s)
  芥田憲夫
- Journal Title
  
  Hepatology
  
  Volume: VOL.52 Pages: 412-429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590866
[Journal Article] Amino acid substitutions in the hepatitis C virus core region of genotype 1b affect very early viral dynamics during treatment with telaprevir, peginterferon, and ribavirin2010
- Author(s)
  Akuta N, Kumada H(他12名, 1番目)
- Journal Title
  
  J Med Virol
  
  Volume: 82 Pages: 575-582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590866
[Journal Article] Amino acid substitutions in the hepatitis C virus core region of genotype]b affect very early viral dynamics during treatment with telaprevir, peginterferon, and ribavirin.2010
- Author(s)
  芥田憲夫
- Journal Title
  
  Journal of Medical Virology
  
  Volume: VOL.82 Pages: 575-582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590866
[Journal Article] Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus2009
- Author(s)
  芥田憲夫
- Journal Title
  
  Journal of Medical Virology VOL.81
  
  Pages: 1032-1039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590866
[Journal Article] A matched case-controlled study of 48 and 72 weeks of peginterferon plus ribavirin combination therapy in patients infected with HCV genotype 1b in Japan : amino acid substitutions in HCV core region as predictor of sustained virological response2009
- Author(s)
  Akuta N, Kumada H(他12名, 1番目)
- Journal Title
  
  J Med Virol
  
  Volume: 81 Pages: 452-458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590866
[Journal Article] Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 2a high viral load and virological response to interferon-ribavirin combination therapy2009
- Author(s)
  芥田憲夫
- Journal Title
  
  Intervirology VOL.52
  
  Pages: 301-309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590866
[Journal Article] Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 2a high viral load and virological response to interferon-ribavirin combination therapy2009
- Author(s)
  Akuta N, Kumada H(他12名, 1番目)
- Journal Title
  
  Intervirology
  
  Volume: 52 Pages: 301-309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590866
[Journal Article] A matched case-controlled study of 48 and 72 weeks of peginterferon plus ribavirin combination therapy in patients infected with HCV genotype 1b in Japan : amino acid substitutions in HCV core region as predictor of sustained virological response2009
- Author(s)
  芥田憲夫
- Journal Title
  
  Journal of Medical Virology VOL.81
  
  Pages: 452-458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590866
[Journal Article] Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus2009
- Author(s)
  Akuta N, Kumada H(他12名, 1番目)
- Journal Title
  
  J Med Virol
  
  Volume: 81 Pages: 1032-1039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590866
[Patent] B型肝炎ウイルス量が低下する可能性を予測する方法2007
- Inventor(s)
  熊田博光, 芥田憲夫
- Industrial Property Rights Holder
  熊田博光, 芥田憲夫
- Industrial Property Number
  2007-340261
- Filing Date
  2007-12-28
- Data Source
  KAKENHI-PROJECT-21590866
[Patent] B型肝炎ウイルス量が低下する可能性を予測する方法2007
- Inventor(s)
  熊田博光・芥田憲夫
- Industrial Property Rights Holder
  熊田博光・芥田憲夫
- Industrial Property Number
  2007-340261
- Filing Date
  2007-12-28
- Data Source
  KAKENHI-PROJECT-21590866
[Patent] C型肝炎に対するインターフェロン/リバビリン併用療法の有効性2005
- Inventor(s)
  熊田博光・芥田憲夫
- Industrial Property Rights Holder
  熊田博光・芥田憲夫
- Patent Publication Number
  2007-043985
- Filing Date
  2005-08-11
- Data Source
  KAKENHI-PROJECT-21590866
[Patent] C型肝炎に対するインターフェロン/リバビリン併用療法の有効性2005
- Inventor(s)
  熊田博光, 芥田憲夫
- Industrial Property Rights Holder
  熊田博光, 芥田憲夫
- Patent Publication Number
  2007-043985
- Filing Date
  2005-08-11
- Data Source
  KAKENHI-PROJECT-21590866
[Presentation] 新規抗HCV療法を含めた難治要因の検討と代謝要因への影響2011
- Author(s)
  芥田憲夫
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-21590866
[Presentation] C型肝炎の治療抵抗性と肝発癌に影響するウイルス・宿主要因の検討2011
- Author(s)
  芥田憲夫
- Organizer
  第15回日本肝臓学会大会
- Place of Presentation
  福岡サンパレス(東京都)
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-21590866
[Presentation] Amino acid substitution in the hepatitis C virus core region of genotype 1b are the important predictor of telaprevir with peginterferon plus ribavirin, and hepatocarcinogenesis2011
- Author(s)
  芥田憲夫
- Organizer
  The 62th annual meeting of the American association for the study of liver disease, 2011
- Place of Presentation
  CA (USA)
- Year and Date
  2011-11-06
- Data Source
  KAKENHI-PROJECT-21590866
[Presentation] HCV coreアミノ酸置換が肝発癌・代謝要因に及ぼす影響2011
- Author(s)
  芥田憲夫
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  ホテルグランパシフィックLE DAIBA(東京都)
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-21590866
[Presentation] Amino acid substitution in the hepatitis C virus core region of genotype 1b are the important predictor of telaprevir with peginterferon plus ribavirin, and hepatocarcinogenesis2011
- Author(s)
  芥田憲夫
- Organizer
  The 62th annual meeting of the American association for the study of liver disease
- Place of Presentation
  CA(USA)
- Year and Date
  2011-11-06
- Data Source
  KAKENHI-PROJECT-21590866
[Presentation] Coreアミノ酸置換とIL28B遺伝子多型のPEG-IFN/RBV/Telaprevir併用療法における有用性2010
- Author(s)
  芥田憲夫
- Organizer
  第38回日本肝臓学会東部会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-21590866
[Presentation] PEG-IFN/RBV/Telaprevir併用療法におけるCore aa70置換とIL28B遺伝子多型の有用性2010
- Author(s)
  芥田憲夫
- Organizer
  第14回日本肝臓学会大会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-21590866
[Presentation] Amino acid substitutions in HCV core region of genotype Ib are the important viral predictors of treatment resistance and hepatocarcinogenesis.2010
- Author(s)
  芥田憲夫
- Organizer
  7th APASL Single Topic Conference Hepatitis C Virus
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-21590866
[Presentation] Coreアミノ酸置換とIL28B遺伝子多型のPEG-IFN/SBV/Telaprevir併用療法における有用性2010
- Author(s)
  芥田憲夫
- Organizer
  第38回日本肝臓学会東部会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-21590866
[Presentation] Amino acid substitutions in HCV core region of genotype 1b are the important viral predictors of treatment resistance and hepatocarcinogenesis2010
- Author(s)
  芥田憲夫
- Organizer
  7th APASL Single Topic Conference"Hepatitis C Virus"
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-21590866
[Presentation] HCV coreアミノ酸置換の新規抗HCV療法・肝発癌に及ぼす影響2010
- Author(s)
  芥田憲夫
- Organizer
  第96回日本消化器病学会総会
- Place of Presentation
  新潟県民会館(新潟県)
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-21590866
[Presentation] 抗ウイルス療法・肝病態におけるHCV-1b core aa70/91の意義2009
- Author(s)
  芥田憲夫
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸ポートピアホテル(兵庫県)
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590866
[Presentation] Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of treatment resistance, insulin resistance, and hepatocarcinogenesis2009
- Author(s)
  芥田憲夫
- Organizer
  The 60th annual meeting of the American association for the study of liver disease
- Place of Presentation
  BOSTON HYNES CONVENTION CENTER(USA)
- Year and Date
  2009-11-01
- Data Source
  KAKENHI-PROJECT-21590866

1. 茶山一彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AKUTA Norio 芥田 憲夫

芥田 憲夫 アクタ ノリオ

Research Projects

Research Products

Co-Researchers

Clinical significance of HCV core region, to antiviral therapy and clinicopatological features.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variati on Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Amino acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment efficacy to interferon plus ribavirin combination therapy2012

Author(s)

Journal Title

Data Source

[Journal Article] Amino acid substitutions in hepatitis C virus core region predict hepatocarcinogenesis following eradication of HCV RNA by antiviral therapy2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Amino acid substitutions in hepatitis C virus core region predict hepatocarcinogenesis following eradication of HCV RNA by antiviral therapy2011

Author(s)

Journal Title

Data Source

[Journal Article] Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin2010

Author(s)

Journal Title

Data Source

[Journal Article] Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin.2010

Author(s)

Journal Title

Data Source

[Journal Article] Amino acid substitutions in the hepatitis C virus core region of genotype 1b affect very early viral dynamics during treatment with telaprevir, peginterferon, and ribavirin2010

Author(s)

Journal Title

Data Source

[Journal Article] Amino acid substitutions in the hepatitis C virus core region of genotype]b affect very early viral dynamics during treatment with telaprevir, peginterferon, and ribavirin.2010

Author(s)

Journal Title

Data Source

[Journal Article] Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus2009

Author(s)

Journal Title

Data Source

[Journal Article] A matched case-controlled study of 48 and 72 weeks of peginterferon plus ribavirin combination therapy in patients infected with HCV genotype 1b in Japan : amino acid substitutions in HCV core region as predictor of sustained virological response2009

Author(s)

Journal Title

Data Source

[Journal Article] Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 2a high viral load and virological response to interferon-ribavirin combination therapy2009

Author(s)

Journal Title

Data Source

[Journal Article] Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 2a high viral load and virological response to interferon-ribavirin combination therapy2009

Author(s)

Journal Title

Data Source

[Journal Article] A matched case-controlled study of 48 and 72 weeks of peginterferon plus ribavirin combination therapy in patients infected with HCV genotype 1b in Japan : amino acid substitutions in HCV core region as predictor of sustained virological response2009

Author(s)

Journal Title

Data Source

[Journal Article] Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus2009

Author(s)

Journal Title

Data Source

[Patent] B型肝炎ウイルス量が低下する可能性を予測する方法2007

Inventor(s)

Industrial Property Rights Holder

Industrial Property Number

Filing Date

Data Source

[Patent] B型肝炎ウイルス量が低下する可能性を予測する方法2007

Inventor(s)

Industrial Property Rights Holder

Industrial Property Number

Filing Date

AKUTA Norio 芥田憲夫

芥田憲夫アクタノリオ