OISHI NAOKI 大石尚毅

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大石尚毅オオイシナオキ

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Researcher Number	20507040
Affiliation (based on the past Project Information) *help	2016 – 2017: 金沢大学, 医学系, 協力研究員 2015: 金沢大学, 医薬保健学総合研究科, 特任准教授 2010: Kanazawa University, 大学病院, 助教
Review Section/Research Field	Principal Investigator Gastroenterology
Keywords	Principal Investigator CD56 / CD133 / EpCAM / DNMT阻害剤 / HDAC阻害剤 / 癌幹細胞 / DNAメチル化制御タンパク阻害薬 / ヒストン修飾タンパク阻害薬 / 上皮間葉系移行 / 肝細胞癌

Identification of new therapy for HCC based on stemness surface markersPrincipal Investigator
- Principal Investigator
  
  OISHI NAOKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
ヒト肝細胞発癌過程の病態解明と新規治療法の開発Principal Investigator
- Principal Investigator
  
  大石尚毅
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University

All 2017 2016 2015

All Journal Article Presentation Book

[Book] 肝内胆管癌の遺伝子発現による分類2016
- Author(s)
  大石尚毅
- Total Pages
  5
- Publisher
  アークメディア
- Data Source
  KAKENHI-PROJECT-15K08992
[Journal Article] Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B.2017
- Author(s)
  Wang X, Oishi N, Shimakami T, Yamashita T, Honda M, Murakami S, Kaneko S.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 23 Issue: 18 Pages: 3252-3261
- DOI
  10.3748/wjg.v23.i18.3252
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-15K08992
[Journal Article] Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD90.2017
- Author(s)
  5.Yoshida M, Yamashita T, Okada H, Oishi N, Nio K, Hayashi T, Nomura Y, Hayashi T, Asahina Y, Ohwada M, Sunagozaka H, Takatori H, Colombo F, Porretti L, Honda M, Kaneko S.
- Journal Title
  
  Scientific Reports.
  
  Volume: 12;7(1) Issue: 1 Pages: 11292-11292
- DOI
  10.1038/s41598-017-11848-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H04695, KAKENHI-PROJECT-15K08992
[Journal Article] TSU-68 ameliorates hepatocellular carcinoma growth by inhibiting microenvironmental platelet-derived growth factor signaling.2015
- Author(s)
  Hara Y, Yamashita T, Oishi N, Nio K, Hayashi T, Nomura Y, Yoshida M, Hayashi T, Hashiba T, Asahina Y, Kondo M, Okada H, Sunagozaka H, Honda M, Kaneko S
- Journal Title
  
  Anticancer R.
  
  Volume: 3 Pages: 1423-31
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08992
[Journal Article] Defeating EpCAM(+) liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma.2015
- Author(s)
  Nio K, Yamashita T, Okada H, Kondo M, Hayashi T, Hara Y, Nomura Y, Zeng SS, Yoshida M, Hayashi T, Sunagozaka H, Oishi N, Honda M, Kaneko S
- Journal Title
  
  J. Hepatology
  
  Volume: 5 Issue: 5 Pages: 1164-72
- DOI
  10.1016/j.jhep.2015.06.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08992, KAKENHI-PROJECT-26460994, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378, KAKENHI-PROJECT-25293171
[Presentation] 幹細胞および上皮間葉系移行表面抗原による予後不良肝癌の同定とEpCAM発現調節機構の解明2016
- Author(s)
  大石尚毅、山下太郎、金子周一
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  千葉県
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K08992
[Presentation] HNF4AはEOB-MRI肝細胞相高信号のHCCにおいて成熟肝細胞様の特徴を維持に重要である。2016
- Author(s)
  大石尚毅、山下太郎、金子周一
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  東京都
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K08992
[Presentation] トランスクリプトーム解析による予後不良肝癌の病態と治療標的の解明2015
- Author(s)
  大石尚毅
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本(熊本県熊本市)
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K08992

1. YAMASHITA Taro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 本多政夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 島上哲朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 岡田光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OISHI NAOKI 大石 尚毅

大石 尚毅 オオイシ ナオキ

Research Projects

Research Products

Co-Researchers

Identification of new therapy for HCC based on stemness surface markersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト肝細胞発癌過程の病態解明と新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 肝内胆管癌の遺伝子発現による分類2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD90.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TSU-68 ameliorates hepatocellular carcinoma growth by inhibiting microenvironmental platelet-derived growth factor signaling.2015

Author(s)

Journal Title

Data Source

[Journal Article] Defeating EpCAM(+) liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] 幹細胞および上皮間葉系移行表面抗原による予後不良肝癌の同定とEpCAM発現調節機構の解明2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] HNF4AはEOB-MRI肝細胞相高信号のHCCにおいて成熟肝細胞様の特徴を維持に重要である。2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] トランスクリプトーム解析による予後不良肝癌の病態と治療標的の解明2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

OISHI NAOKI 大石尚毅

大石尚毅オオイシナオキ