kawate hisaka 河手久香

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Kawate Hisaka 河手久香

KAWATE Hisaka 河手久香

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Researcher Number	20507503
Other IDs
Affiliation (Current)	2025: 信州大学, 医学部, 研究員
Affiliation (based on the past Project Information) *help	2018 – 2023: 信州大学, 医学部, 研究員 2017: 信州大学, 医学系研究科, 研究員 2014 – 2015: 信州大学, 医学系研究科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / General internal medicine(including psychosomatic medicine) / Pathological medical chemistry
Keywords	Principal Investigator RAMP / アドレノメデュリン / 受容体活性調節タンパク / リンパ管 / 血管 / 転移 / 癌 / フレイル / RAMP2 / サルコペニア … More / 骨格筋 / 老年医学 / 代謝障害 / 性差医療 / 病態医化学 Less

RAMP2、3の機能分化の解明と、癌の血行性およびリンパ行性転移抑制への応用Principal Investigator
- Principal Investigator
  
  河手久香
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Shinshu University
Elucidation of the skeletal muscle regulatory mechanism of the AM-RAMP2 system and its application to sarcopenia and frailty.Principal Investigator
- Principal Investigator
  
  Kawate Hisaka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Shinshu University
Gender-specific medicine for age-related disease based on a novel metabolic regulatory systemPrincipal Investigator
- Principal Investigator
  
  Kawate Hisaka
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Shinshu University
Novel homeostatic system, which regulates functional relationship between WAT and BATPrincipal Investigator
- Principal Investigator
  
  KAWATE Hisaka
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinshu University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Receptor activity modifying protein RAMP sub-isoforms and their functional differentiation, which regulates functional diversity of adrenomedullin2022
- Author(s)
  Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Sakurai T
- Journal Title
  
  Biology(Basel)
  
  Volume: 11(5) Issue: 5 Pages: 788-788
- DOI
  10.3390/biology11050788
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06855, KAKENHI-PROJECT-22K15524, KAKENHI-PROJECT-22KJ1493, KAKENHI-PROJECT-20K07845, KAKENHI-PROJECT-20K09803, KAKENHI-PROJECT-20K21569, KAKENHI-PROJECT-21H02669
[Journal Article] Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress.2021
- Author(s)
  Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shind T.
- Journal Title
  
  Endocrinology.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07845
[Journal Article] Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-b-Smads signaling and myofibroblast differentiation2021
- Author(s)
  Wei Y, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T
- Journal Title
  
  Endocrinology
  
  Volume: 162(8) Issue: 8 Pages: 1-22
- DOI
  10.1210/endocr/bqab090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07317, KAKENHI-PROJECT-19K07477, KAKENHI-PROJECT-20K16299, KAKENHI-PROJECT-20K07845, KAKENHI-PROJECT-20K09803, KAKENHI-PROJECT-21K06868, KAKENHI-PROJECT-20K21569, KAKENHI-PROJECT-22KJ1493, KAKENHI-PROJECT-21H02669
[Journal Article] Adrenomedullin-receptor activity-modifying protein 2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in age-related macular degeneration2021
- Author(s)
  Tanaka M, Kakihara S, Hirabayashi K, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Aruga K, Yamauchi A, Murata T, Shindo T
- Journal Title
  
  Am J Pathol
  
  Volume: 191(4) Issue: 4 Pages: 652-668
- DOI
  10.1016/j.ajpath.2020.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07317, KAKENHI-PROJECT-19K07477, KAKENHI-PROJECT-20K07845, KAKENHI-PROJECT-20K09803, KAKENHI-PROJECT-20K21569, KAKENHI-PROJECT-20K16299, KAKENHI-PROJECT-18H02602, KAKENHI-PROJECT-18J40224, KAKENHI-PROJECT-21H02669
[Journal Article] Adrenomedullin-RAMP2 system ameliorates pulmonary fibrosis by regulating TGF-β-Smads pathway and differentiation of myofibroblasts.2021
- Author(s)
  Wei Y, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui1 N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T.
- Journal Title
  
  Endocrinology.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07845
[Journal Article] Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress2021
- Author(s)
  Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T
- Journal Title
  
  Endocrinology
  
  Volume: 162(3) Issue: 3 Pages: 0-0
- DOI
  10.1210/endocr/bqab001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07317, KAKENHI-PROJECT-20K16299, KAKENHI-PROJECT-18J40224, KAKENHI-PROJECT-19K07477, KAKENHI-PROJECT-20K07845, KAKENHI-PROJECT-20K09803, KAKENHI-PROJECT-20K21569, KAKENHI-PROJECT-21H02669
[Journal Article] Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts2020
- Author(s)
  Dai K, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Matsui S, Shindo T
- Journal Title
  
  Oncogene
  
  Volume: 39(9) Issue: 9 Pages: 1914-1930
- DOI
  10.1038/s41388-019-1112-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07317, KAKENHI-PROJECT-17K08588, KAKENHI-PROJECT-17K09296, KAKENHI-PROJECT-19K07477, KAKENHI-PROJECT-20K07845, KAKENHI-PROJECT-20K09803, KAKENHI-PROJECT-20K21569, KAKENHI-PROJECT-18J40224, KAKENHI-PROJECT-18H02602
[Journal Article] Endogenous Calcitonin Gene-Related Peptide Deficiency Exacerbates Postoperative Lymphedema by Suppressing Lymphatic Capillary Formation and M2 Macrophage Accumulation2019
- Author(s)
  Matsui S, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Dai K, Cui N, Wei Y, Tanaka M, Kakihara S, Nakamura K, Yamauchi A, Ishida K, Tanaka S, Kawamata M, Shindo T
- Journal Title
  
  Am J Pathol
  
  Volume: 189(12) Issue: 12 Pages: 2487-2502
- DOI
  10.1016/j.ajpath.2019.08.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07317, KAKENHI-PROJECT-17K08588, KAKENHI-PROJECT-17K09296, KAKENHI-PROJECT-18H02602, KAKENHI-PROJECT-18J40224
[Journal Article] Development of a novel model of central retinal vascular occlusion and the therapeutic potential of the adrenomedullin-RAMP2 system.2019
- Author(s)
  Hirabayashi K, Tanaka M, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Dai K, Cui N, Wei Y, Nakamura K, Iida S, Matsui S, Yamauchi A, Murata T, Shindo T.
- Journal Title
  
  Am J Pathol.
  
  Volume: 189 Issue: 2 Pages: 449-466
- DOI
  10.1016/j.ajpath.2018.10.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09296, KAKENHI-PROJECT-18J40224, KAKENHI-PROJECT-16K08545, KAKENHI-PROJECT-18H00481, KAKENHI-PROJECT-18H02602
[Journal Article] Regulation of cardiovascular development and homeostasis by the adrenomedullin-RAMP system2019
- Author(s)
  Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Sakurai T.
- Journal Title
  
  Peptides.
  
  Volume: 111 Pages: 55-61
- DOI
  10.1016/j.peptides.2018.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08588, KAKENHI-PROJECT-17K09296, KAKENHI-PROJECT-18H02602, KAKENHI-PROJECT-18J40224, KAKENHI-PROJECT-16K08545, KAKENHI-PROJECT-18H00481
[Journal Article] Development of a novel model of central retinal vascular occlusion and the therapeutic potential of the adrenomedullin-RAMP2 system.2019
- Author(s)
  Hirabayashi K, Tanaka M, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Dai K, Cui N, Wei Y, Nakamura K, Iida S, Matsui S, Yamauchi A, Murata T, Shindo T.
- Journal Title
  
  Am J Pathol.
  
  Volume: 189 Pages: 449-466
- DOI
  10.1016/j.peptides.2018.10.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08588, KAKENHI-PROJECT-17K09296, KAKENHI-PROJECT-18H02602, KAKENHI-PROJECT-18J40224, KAKENHI-PROJECT-16K08545, KAKENHI-PROJECT-18H00481
[Journal Article] Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline2018
- Author(s)
  Zhai L, Tanaka M, et al.
- Journal Title
  
  J Hypertens.
  
  Volume: 36 Issue: 4 Pages: 876-891
- DOI
  10.1097/hjh.0000000000001649
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06841, KAKENHI-PROJECT-16K15233, KAKENHI-PROJECT-17K08588, KAKENHI-PROJECT-17K09296, KAKENHI-PROJECT-18H02602, KAKENHI-PROJECT-18H00481
[Journal Article] Adrenomedullin Suppresses Vascular Endothelial Growth Factor-Induced Vascular Hyperpermeability and Inflammation in Retinopathy.2017
- Author(s)
  Imai A, Toriyama Y, Iesato Y, Hirabayasi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Zhai L, Dai K, Tanimura K, Liu T, Cui N, Yamauchi A, Murata T, Shindo T
- Journal Title
  
  American journal of Pathology
  
  Volume: 187(5) Issue: 5 Pages: 999-1015
- DOI
  10.1016/j.ajpath.2017.01.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06244, KAKENHI-PROJECT-26293085, KAKENHI-PROJECT-16K15233, KAKENHI-PROJECT-16K08545, KAKENHI-PROJECT-17K08588, KAKENHI-PROJECT-17K09296
[Journal Article] アドレノメデュリン-RAMP2系は転移前土壌形成を抑制し、癌転移を抑制する2017
- Author(s)
  田中愛、小山晃英、桜井敬之、神吉昭子、新藤優佳、河手久香、新藤隆行他
- Journal Title
  
  血管
  
  Volume: 40 Pages: 101-106
- Data Source
  KAKENHI-PROJECT-17K09296
[Journal Article] Vasoprotective activities of the adrenomedullin-RAMP2 system in endothelial cells2017
- Author(s)
  Xian X, Tanaka M, et al.
- Journal Title
  
  Endocrinology
  
  Volume: 158 Issue: 5 Pages: 1359-1372
- DOI
  10.1210/en.2016-1531
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06841, KAKENHI-PROJECT-26293085, KAKENHI-PROJECT-26293183, KAKENHI-PROJECT-26460337, KAKENHI-PROJECT-16K08545, KAKENHI-PROJECT-16K15233, KAKENHI-PROJECT-16H00679, KAKENHI-PROJECT-17K08588, KAKENHI-PROJECT-17K09296
[Journal Article] Endogenous calcitonin gene-related peptide regulates lipid metabolism and energy homeostasis in male mice2017
- Author(s)
  Liu T, Tanaka M, et al.
- Journal Title
  
  Endocrinology
  
  Volume: 158 Issue: 5 Pages: 1194-1206
- DOI
  10.1210/en.2016-1510
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06841, KAKENHI-PROJECT-26293085, KAKENHI-PROJECT-26293183, KAKENHI-PROJECT-26460337, KAKENHI-PROJECT-16K08545, KAKENHI-PROJECT-16K15233, KAKENHI-PROJECT-16H00679, KAKENHI-PROJECT-17K08588, KAKENHI-PROJECT-17K09296
[Journal Article] Adrenomedullin-RAMP2 System in Vascular Endothelial Cells2015
- Author(s)
  Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Shindo T.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 22 Issue: 7 Pages: 647-653
- DOI
  10.5551/jat.29967
- NAID
  130005089126
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460337, KAKENHI-PROJECT-15K19185, KAKENHI-PROJECT-26893102, KAKENHI-PROJECT-25460330, KAKENHI-PROJECT-26670153, KAKENHI-PROJECT-26293085, KAKENHI-PROJECT-26293183
[Journal Article] Pathophysiological Function of Endogenous Calcitonin Gene-Related Peptide in Ocular Vascular Diseases2015
- Author(s)
  Toriyama Y, Tanaka M et al.
- Journal Title
  
  Am J Pathol.
  
  Volume: 185 Issue: 6 Pages: 1-13
- DOI
  10.1016/j.ajpath.2015.02.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J07817, KAKENHI-PROJECT-26893102, KAKENHI-PROJECT-25460330
[Journal Article] アドレノメデュリン受容体システムの機能分化と、血管･リンパ管の制御機構2014
- Author(s)
  山内啓弘、桜井敬之、神吉昭子、新藤優佳、河手久香、五十嵐恭子、鳥山佑一、田中愛、劉甜、羨鮮、Zhai Liuyu、荒居琢磨、新藤隆行
- Journal Title
  
  リンパ学
  
  Volume: 37 Pages: 57-61
- Data Source
  KAKENHI-PROJECT-26893102
[Journal Article] 血管、臓器恒常性を制御する生体内システム、アドレノメデュリンとその受容体活性調節システムの病態生理学的意義2014
- Author(s)
  新藤隆行、桜井敬之、神吉昭子、新藤優佳、河手久香、小山晃英
- Journal Title
  
  日薬理誌
  
  Volume: 143 Pages: 232-235
- NAID
  130004827694
- Data Source
  KAKENHI-PROJECT-26893102
[Journal Article] Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection2014
- Author(s)
  Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M, Mukoyama M, Shindo T
- Journal Title
  
  PLoS One.
  
  Volume: 9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26893102
[Journal Article] アドレノメデュリン－RAMP2システムによる、白色脂肪、褐色脂肪の脂質、エネルギー代謝制御2014
- Author(s)
  神吉昭子、桜井敬之、河手久香、新藤優佳、植竹龍一、山内啓弘、五十嵐恭子、鳥山佑一、田中愛、劉甜、羨鮮、今井章、Zhai Liuyu、大和慎治、新藤隆行
- Journal Title
  
  血管
  
  Volume: 37 Pages: 135-139
- Data Source
  KAKENHI-PROJECT-26893102
[Journal Article] Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia2014
- Author(s)
  Igarashi K, Tanaka M et al.
- Journal Title
  
  Peptides
  
  Volume: 62 Pages: 21-31
- DOI
  10.1016/j.peptides.2014.08.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J07817, KAKENHI-PROJECT-25460330, KAKENHI-PROJECT-25893225, KAKENHI-PROJECT-26460337, KAKENHI-PROJECT-26893102
[Journal Article] Function differentiation of RAMP2 and RAMP3 in their regulation of the vascular system2014
- Author(s)
  Yamauchi A, Tanaka M et al.
- Journal Title
  
  J Mol Cell Cardiol.
  
  Volume: 77 Pages: 73-85
- DOI
  10.1016/j.yjmcc.2014.09.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J07817, KAKENHI-PROJECT-25460330, KAKENHI-PROJECT-26293183, KAKENHI-PROJECT-26460337, KAKENHI-PROJECT-26893102
[Presentation] AM-RAMP2系は、高内皮細静脈(HEV)の恒常性を制御し、リンパ節転移を抑制する2023
- Author(s)
  田中愛、桜井敬之、神吉昭子、新藤優佳、河手久香、ZHAO YUNLU、松田順繁、ZHANG YAN、GUO QIANQIAN、星山健、LI PEIXUAN、LI JIAKE、大西菜穂、林真倫那、笠原智貴、甲斐健佑、新藤隆行
- Organizer
  第6回日本腫瘍循環器学会
- Data Source
  KAKENHI-PROJECT-23K06850
[Presentation] Vascular homeostatic function of the AM-RAMP2 system and its application to the regulation of lymph node metastasis.2023
- Author(s)
  Tanaka M, Sakurai T, Kamiyoshi K, Ichikawa-Shindo Y, Kawate H, Kakihara S, Zhao Y, Matsuda Y, Zhang Y, Guo Q, Li P, Onishi N, Kasahara T, Shindo T.
- Organizer
  第87回日本循環器学会
- Data Source
  KAKENHI-PROJECT-23K06850
[Presentation] アドレノメデュリン2の肝臓および代謝制御における病態生理学的意義2022
- Author(s)
  神吉昭子、桜井敬之、新藤優佳、河手久香、田中愛、柿原伸次、Zhao Yunlu、松田順繁、Zhang Yan、Guo Qianqian、Li Peixuan、大西菜穂、笠原智、新藤隆行
- Organizer
  第43回日本肥満学会
- Data Source
  KAKENHI-PROJECT-20K07845
[Presentation] サルコペニア病態におけるアドレノメデュリン-RAMP系の病態生理学的意義2021
- Author(s)
  有賀公亮、桜井敬之、神吉昭子、市川優佳、河手久香、田中愛、柿原伸次、Zhao Yunlu、松田順繁、新藤隆行
- Organizer
  第25回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-20K07845
[Presentation] Adrenomedullin-RAMP2 system ameliorates age-related macular degeneration by suppressing choroidal neovascularization and subretinal fibrosis.2021
- Author(s)
  Tanaka M, Kakihara S, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Kasahara T, Aruga K, Shindo T.
- Organizer
  第85回日本循環器学会
- Data Source
  KAKENHI-PROJECT-20K07845
[Presentation] 肥満および脂肪肝におけるアドレノメデュリン2の病態生理学的意義2021
- Author(s)
  肥満および脂肪肝におけるアドレノメデュリン2の病態生理学的意義神吉昭子、桜井敬之、新藤優佳、河手久香、田中愛、崔南奇、田中正明、Wei Yangxuan、柿原伸次、Zhao Yunlu、笠原智貴、有賀公亮、新藤隆行
- Organizer
  第94回日本内分泌学会
- Data Source
  KAKENHI-PROJECT-20K07845
[Presentation] Adrenomedullin-RAMP2 system regulates vascular endothelial homeostasis, which suppresses hematogenous and lymphogenous metastasis.2021
- Author(s)
  Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Zhao Y, Kasahara T, Aruga K, Shindo T.
- Organizer
  第85回日本循環器学会
- Data Source
  KAKENHI-PROJECT-20K07845
[Presentation] Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress.2021
- Author(s)
  Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Wei Y, Tanaka M, Kakihara S, Zhao Y, Kasahara T, Aruga K, Shindo T.
- Organizer
  第85回日本循環器学会
- Data Source
  KAKENHI-PROJECT-20K07845
[Presentation] 加齢黄斑変性におけるアドレノメデュリン-RAMP系の病態生理学的意義2019
- Author(s)
  田中正明、柿原伸次、桜井敬之、神吉昭子、市川優佳、田中愛、河手久香、戴昆、村田敏規、新藤隆行
- Organizer
  第23回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders2019
- Author(s)
  Kamiyoshi A, Sakurai T, Kawate H, Ichikawa-Shindo Y,Shindo T.et al.
- Organizer
  第83回日本循環器学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] アドレノメデュリン-RAMP2系は、筋線維芽細胞分化抑制により、肺線維症の病態を改善する2019
- Author(s)
  Wei Yangxuan、神吉昭子、桜井敬之、新藤優佳、河手久香、田中愛、戴昆、崔南奇、新藤隆行
- Organizer
  第23回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] アドレノメデュリン‐RAMP3系の欠損は、癌関連線維芽細胞におけるポドプラニン発現の制御により臓器間転移を抑制する2019
- Author(s)
  戴昆、田中愛、桜井敬之、神吉昭子、新藤優佳、河手久香、平林一貴、崔南奇、Wei Yangxuan、田中正明、松井周平、中村啓成、新藤隆行
- Organizer
  第28回日本がん転移学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] 脂肪細胞のミトコンドリア機能制御におけるアドレノメデュリン-RAMP2系の病態生理学的意義2019
- Author(s)
  神吉昭子、桜井敬之、新藤優佳、河手久香、田中愛、田中正明、柿原伸次、松井周平、中村啓成、新藤隆行
- Organizer
  第23回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] Loss of adrenomedullin-RAMP3 system suppresses inter-organ metastasis by regulation of podoplanin (PDPN) expression in cancer-associated fibroblasts (CAFs)2019
- Author(s)
  Dai K, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Matsui S, Nakamura K, Kakihara S, Yamauchi A, Shindo T.
- Organizer
  第78回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] 血管内皮細胞アドレノメデュリンーRAMP2系の、リンパ節転移における病態生理学的意義2019
- Author(s)
  田中愛、戴昆、桜井敬之、神吉昭子、新藤優佳、河手久香、崔南奇、Wei Yangxuan、田中正明、柿原伸次、松井周平、新藤隆行
- Organizer
  第27回日本血管生物医学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] アドレノメデュリン-RAMP2系はヒト網膜色素上皮細胞の上皮間葉転換を抑制する2019
- Author(s)
  田中正明、平林一貴、今井章、鳥山佑一、家里康弘、桜井敬之、神吉昭子、新藤優佳、河手久香、田中愛、山内啓弘、村田敏規、新藤隆行
- Organizer
  第123回日本眼科学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] アドレノメデュリン-RAM2, 3系は、心血管系ストレスに対して、心臓恒常性を制御する2019
- Author(s)
  崔南奇、神吉昭子、桜井敬之、新藤優佳、河手久香、田中愛、戴昆、Wei Yangxuan、松井周平、新藤隆行
- Organizer
  第23回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] Pathophysiological significance of adrenomedullin-RAMP2 system in age-related macular degeneration2019
- Author(s)
  Tanaka M, Hirabayashi K, Iesato Y, Imai A, Toriyama Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Yamauchi A, Murata T, Shindo T.
- Organizer
  The Association for Research in Vision and Ophthalmology (ARVO) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] AM-RAMP2系はTGFβ-CXCR4系を抑制し、網膜線維化を抑制する2019
- Author(s)
  田中正明、平林一貴、今井章、鳥山佑一、家里康弘、桜井敬之、神吉昭子、新藤優佳、河手久香、田中愛、山内啓弘、村田敏規、新藤隆行
- Organizer
  第73回日本臨床眼科学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] アドレノメデュリン‐RAMP3系欠損は、癌関連線維芽細胞(CAF)の活性を抑制し、癌転移を抑制する2019
- Author(s)
  戴昆、田中愛、神吉昭子、桜井敬之、新藤優佳、河手久香、崔南奇、Wei Yangxuan、新藤隆行
- Organizer
  第23回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] Regulation of cytoskeleton and energy metabolism of adipocytes by adrenomedullin-RAMP2 system2018
- Author(s)
  Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Shindo T, et al.
- Organizer
  第82回日本循環器学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] アドレノメデュリン－RAMP2系による脂肪細胞の細胞骨格とエネルギー代謝制御機構2018
- Author(s)
  神吉昭子、桜井敬之、河手久香、新藤優佳、新藤隆行　他
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] アドレノメデュリン－RAMP2系は褐色脂肪細胞とベージュ脂肪細胞の分化を制御する2017
- Author(s)
  神吉昭子、桜井敬之、河手久香、新藤優佳、新藤隆行　他
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] アドレノメデュリン－RAMP2系による、脂肪細胞の細胞骨格およびエネルギー代謝制御機構2017
- Author(s)
  神吉昭子、桜井敬之、新藤優佳、河手久香、新藤隆行　他
- Organizer
  第21回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-17K09296
[Presentation] Adrenomedullin-RAMP2 system regulates differentiation and lipid metabolism of white and brown adipose tissues2016
- Author(s)
  Kamiyoshi A, Kawate H, Shindo T. et al.
- Organizer
  第80回日本循環器学会
- Place of Presentation
  仙台　仙台国際センター
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-26893102
[Presentation] アドレノメデュリン－RAMP2システムは、褐色脂肪細胞の細胞分化とエネルギー代謝を制御する2016
- Author(s)
  神吉昭子、河手久香、新藤隆行 et al
- Organizer
  第45回日本心脈管作動物質学会
- Place of Presentation
  徳島　阿波観光ホテル
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PROJECT-26893102
[Presentation] アドレノメデュリン－RAMP2システムによる白色脂肪と褐色脂肪の脂質、エネルギー代謝制御2015
- Author(s)
  神吉昭子、河手久香、新藤隆行 et al.
- Organizer
  第88回日本内分泌学会
- Place of Presentation
  東京　ホテルニューオータニ東京
- Year and Date
  2015-04-25
- Data Source
  KAKENHI-PROJECT-26893102
[Presentation] アドレノメデュリン－RAMP2系による、白色脂肪と褐色脂肪の脂質代謝と分化制御2015
- Author(s)
  神吉昭子、河手久香、新藤隆行 et al.
- Organizer
  第36回日本肥満学会
- Place of Presentation
  名古屋　名古屋国際会議場
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-26893102
[Presentation] アドレノメデュリン－RAMP2システムは、白色脂肪―褐色脂肪間の脂質、エネルギー代謝バランスを制御する2014
- Author(s)
  神吉昭子、桜井敬之、新藤優佳、河手久香、劉甜、羨鮮、今井章、Liuyu Zhai、大和慎治、新藤隆行
- Organizer
  第18回日本心血管内分泌代謝学会
- Place of Presentation
  横浜､横浜市開港記念館
- Year and Date
  2014-11-22
- Data Source
  KAKENHI-PROJECT-26893102
[Presentation] アドレノメデュリン－RAMP2システムは、白色脂肪－褐色脂肪間の脂質、エネルギー代謝を制御する
- Author(s)
  神吉昭子、桜井敬之、新藤優佳、河手久香、山内啓弘、五十嵐恭子、鳥山佑一、田中愛、劉甜、羨鮮、今井章、Liuyu Zhai、大和慎治、新藤隆行
- Organizer
  第44回日本心脈管作動物質学会
- Place of Presentation
  香川、高松センタービル
- Year and Date
  2015-02-06 – 2015-02-07
- Data Source
  KAKENHI-PROJECT-26893102

1. KAMIYOSHI Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
2. IMAI Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. SHINDO Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 村田敏規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 鳥山佑一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 田中愛

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

kawate hisaka 河手 久香

Kawate Hisaka 河手 久香

KAWATE Hisaka 河手 久香

Research Projects

Research Products

Co-Researchers

RAMP2、3の機能分化の解明と、癌の血行性およびリンパ行性転移抑制への応用Principal Investigator

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Elucidation of the skeletal muscle regulatory mechanism of the AM-RAMP2 system and its application to sarcopenia and frailty.Principal Investigator

Principal Investigator

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Gender-specific medicine for age-related disease based on a novel metabolic regulatory systemPrincipal Investigator

Principal Investigator

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Novel homeostatic system, which regulates functional relationship between WAT and BATPrincipal Investigator

Principal Investigator

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[Journal Article] Receptor activity modifying protein RAMP sub-isoforms and their functional differentiation, which regulates functional diversity of adrenomedullin2022

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[Journal Article] Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress.2021

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[Journal Article] Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-b-Smads signaling and myofibroblast differentiation2021

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[Journal Article] Adrenomedullin-receptor activity-modifying protein 2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in age-related macular degeneration2021

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[Journal Article] Adrenomedullin-RAMP2 system ameliorates pulmonary fibrosis by regulating TGF-β-Smads pathway and differentiation of myofibroblasts.2021

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[Journal Article] Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress2021

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[Journal Article] Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts2020

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[Journal Article] Endogenous Calcitonin Gene-Related Peptide Deficiency Exacerbates Postoperative Lymphedema by Suppressing Lymphatic Capillary Formation and M2 Macrophage Accumulation2019

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[Journal Article] Development of a novel model of central retinal vascular occlusion and the therapeutic potential of the adrenomedullin-RAMP2 system.2019

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[Journal Article] Regulation of cardiovascular development and homeostasis by the adrenomedullin-RAMP system2019

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[Journal Article] Development of a novel model of central retinal vascular occlusion and the therapeutic potential of the adrenomedullin-RAMP2 system.2019

Author(s)

kawate hisaka 河手久香

Kawate Hisaka 河手久香

KAWATE Hisaka 河手久香