KAKAZU EIJI 嘉数英二

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KAKAZU Eiji 嘉数英二

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Researcher Number	20509377
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立国際医療研究センター, 肝炎・免疫研究センター, 医師
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人国立国際医療研究センター, 肝炎・免疫研究センター, 医師 2021 – 2023: 東北大学, 医学系研究科, 大学院非常勤講師 2017 – 2020: 東北大学, 大学病院, 助教 2018: 東北大学, 東北大学病院, 助教 2015 – 2016: 東北大学, 高度教養教育・学生支援機構, 助教 … More 2015: 東北大学, 学内共同利用施設等, 助教 2014: 東北メディカル・メガバンク機構, 学内共同利用施設等, 非常勤講師 2013 – 2014: 東北大学, 東北メディカル・メガバンク機構, 非常勤講師 2013: 東北大学, メディカルメガバンク, 助教(トモフェロー) 2013: 東北大学, 東北メディカルメガバンク機構, 非常勤講師 2012: 東北大学, 東北メディカル・メガバンク機構, 助教 2011: 東北大学, 大学病院, 医員 2009 – 2010: Tohoku University, 病院, 医員 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator アミノ酸 / 非アルコール性脂肪性肝炎 / NASH / NAFLD / 非アルコール性脂肪性肝疾患 / 遊離アミノ酸 / 門脈血 / 酸化ストレス / 非代償性肝硬変 / 単球 … More / 肝硬変 / ミトコンドリア / MASH / MASLD / VLDL / 門脈 / 小胞体ストレス / オレイン酸 / パルミチン酸 / 肝細胞 / 潅流培養 / 3D培養 / 脂肪肝 / メタボローム解析 / アミノ酸不均衡 / L-グルタミン酸 / 免疫 / L-シスチン / 腎機能障害 / 血漿アミノ酸不均衡 / mTOR / 樹状細胞 / xCT / 分岐鎖アミノ酸 … More Except Principal Investigator 肝細胞癌 / エキソソーム / HBV / チロシンキナーゼ阻害薬 / 微小環境 / microRNA / 耐性 / ウイルス性肝炎 / B型肝炎ウイルス / Rabタンパク質 / B型慢性肝炎 / CD63 / Rab5B / 小胞輸送 / 癌幹細胞 / 機能性RNA / PS-L1 / 免疫抑制細胞 / 免疫細胞 / HCV / Tregs / PD-L1 / MDSCs / HCC Less

Exploring the Relationship between Intra- and Extracellular Free Amino Acid Imbalance and Mitochondrial TCA Cycle Function in HepatocytesPrincipal Investigator
- Principal Investigator
  
  嘉数英二
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Center for Global Health and Medicine
肝癌のチロシンキナーゼ阻害薬に対する耐性獲得機序の解明と耐性克服薬の探索
- Principal Investigator
  
  小暮高之
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Impact of free amino acids on intracellular stress response mechanisms in hepatic steatosis.Principal Investigator
- Principal Investigator
  
  Kakazu Eiji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku University
Mechanistic analysis of hepatitis B virus infection focusing on vesicle trafficking system and its clinical application
- Principal Investigator
  
  Inoue Jun
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku University
Analysis of the mechanism of tumor microenvironment modulation through exosomes in hepatocellular cancer stem cells
- Principal Investigator
  
  Kogure Takayuki
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku Medical and Pharmaceutical University
  Tohoku University
Elucidation of the association between non alcoholic steatohepatitis and endoplasmic reticulum stress by metabolomics of portal bloodPrincipal Investigator
- Principal Investigator
  
  KAKAZU EIJI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Development of HCC treatment by analyzing the induction of MDSC, TAM and Tregs
- Principal Investigator
  
  Kondo Yasuteru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Exosomal transfer of functional RNA in hepatocellular carcinoma cell proliferation
- Principal Investigator
  
  Kogure Takayuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
amino acids metabolism and immune abnormality in non alcoholic steatohepatitisPrincipal Investigator
- Principal Investigator
  
  KAKAZU Eiji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
The plasma L-Cystine / L-Glutamate imbalance in cirrhosis influences the function of antigen-presenting cell.Principal Investigator
- Principal Investigator
  
  KAKAZU Eiji
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
The study of amino acids imbalance which influences the immune cells, especially dendritic cells, in patients with advanced cirrhosis.Principal Investigator
- Principal Investigator
  
  KAKAZU Eiji
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University

[Journal Article] Effects of sodium glucose cotransporter 2 inhibitors and pioglitazone on FIB‐4 index in metabolic‐associated fatty liver disease2023
- Author(s)
  Mino Masaaki、Kakazu Eiji、Sano Akitoshi、Katsuyama Hisayuki、Hakoshima Mariko、Yanai Hidekatsu、Aoki Yoshihiko、Imamura Masatoshi、Yamazoe Taiji、Mori Taizo、Yoshio Sachiyo、Inoue Jun、Masamune Atsushi、Kanto Tatsuya
- Journal Title
  
  Hepatology Research
  
  Volume: - Issue: 7 Pages: 618-628
- DOI
  10.1111/hepr.13898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17038, KAKENHI-PROJECT-20K08322, KAKENHI-PROJECT-21K07904
[Journal Article] Steatotic hepatocytes release mature VLDL via methionine and tyrosine metabolism in a Keap1‐Nrf2 dependent manner2021
- Author(s)
  Sano Akitoshi、Kakazu Eiji、Hamada Shin、Inoue Jun、Ninomiya Masashi、Iwata Tomoaki、Tsuruoka Mio、Sato Kosuke、Masamune Atsushi
- Journal Title
  
  Hepatology
  
  Volume: - Issue: 3 Pages: 1271-1286
- DOI
  10.1002/hep.31808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08322
[Journal Article] Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production2019
- Author(s)
  Inoue Jun、Ninomiya Masashi、Umetsu Teruyuki、Nakamura Takuya、Kogure Takayuki、Kakazu Eiji、Iwata Tomoaki、Takai Satoshi、Sano Akitoshi、Fukuda Mitsunori、Watashi Koichi、Isogawa Masanori、Tanaka Yasuhito、Shimosegawa Tooru、McNiven Mark A.、Masamune Atsushi
- Journal Title
  
  Journal of Virology
  
  Volume: 93 Issue: 15
- DOI
  10.1128/jvi.00621-19
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08385, KAKENHI-PROJECT-17K09436, KAKENHI-PROJECT-17H04085
[Journal Article] The profiling of plasma free amino acids and the relationship between serum albumin and plasma-branched chain amino acids in chronic liver disease: a single-center retrospective study.2018
- Author(s)
  Akitoshi Sano, Eiji Kakazu, Tatsuki Morosawa, Jun Inoue, Takayuki Kogure, Masashi Ninomiya, Tomoaki Iwata, Teruyuki Umetsu, Takuya Nakamura, Satoshi Takai, Tooru Shimosegawa
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 印刷中 Issue: 8 Pages: 978-988
- DOI
  10.1007/s00535-018-1435-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09336
[Journal Article] Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1alpha-dependent manner2016
- Author(s)
  Eiji Kakazu, Amy S. Mauer, Meng Yin and Harmeet Malhi
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 57 Issue: 2 Pages: 233-245
- DOI
  10.1194/jlr.m063412
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460972
[Journal Article] Shimosegawa T . Sequential analysis of amino acid substitutions with hepatitis B virus in association with nucleoside/nucleotide analog treatment detected by deep sequencing2014
- Author(s)
  Ninomiya M, Kondo Y, Niihori T, Nagashima T, Kogure T, Kakazu E, Kimura O, Aoki Y, Matsubara Y
- Journal Title
  
  Hepatol Res
  
  Volume: 44(6) Issue: 6 Pages: 678-684
- DOI
  10.1111/hepr.12168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390268, KAKENHI-PROJECT-23791148, KAKENHI-PROJECT-25460970
[Journal Article] HCV infection enhances Th17 commitment, which could affect the pathogenesis of autoimmune diseases2014
- Author(s)
  Kondo Y, Ninomiya M, Kimura O, Machida K, Funayama R, Nagashima T, Kobayashi K, Kakazu E, Kato T, Nakayama K, Lai MM, Shimosegawa T.
- Journal Title
  
  PLoS One
  
  Volume: 9(6) Issue: 6 Pages: e98521-e98521
- DOI
  10.1371/journal.pone.0098521
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460970, KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-26670085, KAKENHI-PROJECT-26830064
[Journal Article] Involvement of microRNA-29a in epigenetic regulation of transforming growth factor-β-induced epithelial-mesenchymal transition in hepatocellular carcinoma2014
- Author(s)
  Kogure T, Kondo Y, Kakazu E, Ninomiya M, Kimura O, Shimosegawa T.
- Journal Title
  
  Hepatol Res.
  
  Volume: 2014 Issue: 8 Pages: 907-919
- DOI
  10.1111/hepr.12188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460970
[Journal Article] Expression of EpCAM Increases in the Hepatitis B Related and the Treatment-Resistant Hepatocellular Carcinoma.2014
- Author(s)
  Kimura O, Kondo Y, Kogure T, Kakazu E, Ninomiya M, Iwata T, Morosawa T, Shimosegawa T.
- Journal Title
  
  BioMed Research International
  
  Volume: 2014 Pages: 172913-172913
- DOI
  10.1155/2014/172913
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460970
[Journal Article] Hepatitis B surface antigen could contribute to the immunopathogenesis of hepatitis B virus infection.2013
- Author(s)
  Yasuteru Kondo et al.
- Journal Title
  
  ISRN Gastroenterol.
  
  Volume: 2013:935295 Pages: 935295-935295
- DOI
  10.1155/2013/935295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790761, KAKENHI-PROJECT-23790762
[Journal Article] Distinct MicroRNAs Expression Profile in Primary Biliary Cirrhosis and Evaluation of miR 505-3p and miR197-3p as Novel Biomarkers2013
- Author(s)
  Ninomiya, M., Kondo, Y., Funayama, R., Nagashima, T., Kogure, T., Kakazu, E., Kimura, O., Ueno, Y., Nakayama, K., Shimosegawa, T.
- Journal Title
  
  PloS one
  
  Volume: 8 Issue: 6 Pages: e66086-e66086
- DOI
  10.1371/journal.pone.0066086
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24116503, KAKENHI-PROJECT-24700951, KAKENHI-PROJECT-25460970
[Journal Article] Eradication ofhepatitis C virus (HCV) could improve the immunological status and pyoderma gangrenosum-like lesion2013
- Author(s)
  Kondo Y, Iwata T, Haga T, Kimura O, Ninomiya M, Kakazu E, Kogure T, Morosawa T, Aiba S, Shimosegawa T.
- Journal Title
  
  Hepatology Research
  
  Volume: 44 Issue: 2 Pages: 4-4
- DOI
  10.1111/hepr.12102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790761, KAKENHI-PROJECT-23790762
[Journal Article] An imbalance of plasma amino acids in patients with cirrhosis disturbs the tricarboxylic acid cycle of dendritic cell.2013
- Author(s)
  Kakazu E, Kondo Y, Kogure T, Ninomoiya M, Kimura O, Shimosegawa T
- Journal Title
  
  Sci Rep.
  
  Volume: 2013 Dec 10;3:3459. Issue: 1 Pages: 3459-3459
- DOI
  10.1038/srep03459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460970, KAKENHI-PROJECT-25460972
[Journal Article] 1(OH) vitamin D3 supplementation improves the sensitivity of the immune-response during Peg-IFN/RBV therapy in chronic hepatitis C patients-case controlled trial2013
- Author(s)
  Kondo Y, Kato T, Kimura O, Iwata T, Ninomiya M, Kakazu E, Miura M, Akahane T, Miyazaki Y, Kobayashi T, Ishii M, Kisara N, Sasaki K, Nakayama H, Igarashi T, Obara N, Ueno Y, Morosawa T, Shimosegawa T.
- Journal Title
  
  PLoS One
  
  Volume: May 23;8(5):e63672. Issue: 5 Pages: e63672-e63672
- DOI
  10.1371/journal.pone.0063672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460970
[Journal Article] Supplementation of branched-chain amino acids maintains the serum albumin level in the course of hepatocellular carcinoma recurrence.2013
- Author(s)
  Kakazu E, Kondo Y, Kogure T, Ninomiya M, Kimura O, Iwata T, Morosawa T, Iwasaki T, Shimosegawa T.
- Journal Title
  
  The Tohoku Journal of Experimental Medicine
  
  Volume: 230 Pages: 191-196
- NAID
  10031194081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460972
[Journal Article] The effect of branched chain amino acid formulation on keeping the serum albumin level in the course of hepatocellular carcinoma recurrence.2013
- Author(s)
  Kakazu E, Kondo Y, Kogure T, Ninomiya M, Kimura O, Iwata T, Morosawa T, Iwasaki T, Shimosegawa T.
- Journal Title
  
  Tohoku J Exp Med.
  
  Volume: 230(4) Pages: 191-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460970
[Journal Article] Relationship between renal dysfunction and abnormalities of the immune system in patients with decompensated cirrhosis2012
- Author(s)
  Kakazu E, Kondo Y, Shimosegawa T
- Journal Title
  
  ISRN Gastroenterology
  
  Volume: 2012 Pages: 123826-123826
- DOI
  10.5402/2012/123826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790761, KAKENHI-PROJECT-23790762
[Journal Article] Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway2012
- Author(s)
  Tamai K, Shiina M, Tanaka N, Nakano T, Yamamoto A, Kondo Y, Kakazu E, Inoue J, Fukushima K, Sano K, Ueno Y, Shimosegawa T, Sugamura K.
- Journal Title
  
  Virology
  
  Volume: 22(2) Issue: 2 Pages: 377-85
- DOI
  10.1016/j.virol.2011.11.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-22790630, KAKENHI-PROJECT-23790762, KAKENHI-PROJECT-24300326
[Journal Article] Sequential Immunological Analysis of HBV/HCV Co-Infected Patients During2012
- Author(s)
  Kondo Y, Ueno Y, Ninomiya M, Tamai K, Tanaka Y, Inoue J, Kakazu E, Kobayashi K, Shimosegawa T
- Journal Title
  
  Peg-IFN/RBV therapy J Gastroenterol
  
  Volume: 47(12) Issue: 12 Pages: 1323-35
- DOI
  10.1007/s00535-012-0596-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790761, KAKENHI-PROJECT-23790762
[Journal Article] 非代償性肝硬変における腎機能低下の要因2012
- Author(s)
  嘉数英二、近藤泰輝、二宮匡史、木村修、下瀬川徹
- Journal Title
  
  消化器内科
  
  Volume: 54(3) Pages: 380-385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790762
[Journal Article] Use of illumina deep sequencing technology to differentiate hepatitis Cvirus variants2012
- Author(s)
  Ninomiya M, Ueno Y, Funayama R, Kagashima T, Nishida Y, Kondo Y, Inoue J, Kakazu E, Kimura O, Nakayama K, Shimosegawa T
- Journal Title
  
  Journal of clinical microbiology
  
  Volume: 50 Issue: 3 Pages: 857-866
- DOI
  10.1128/jcm.05715-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590822, KAKENHI-PROJECT-23790761, KAKENHI-PROJECT-23790762, KAKENHI-PROJECT-23790765, KAKENHI-PROJECT-24700951
[Journal Article] Association between S21 substitution in the core protein of hepatitis B virus and fulminant hepatitis.2012
- Author(s)
  Jun Inoue et al.
- Journal Title
  
  J Clin Virol.
  
  Volume: 55(2) Issue: 2 Pages: 147-152
- DOI
  10.1016/j.jcv.2012.06.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790761, KAKENHI-PROJECT-23790762
[Journal Article] 非代償性肝硬変における腎機能低下の要因2012
- Author(s)
  嘉数英二
- Journal Title
  
  消化器内科
  
  Volume: Vol.54 No.3 Pages: 380-385
- Data Source
  KAKENHI-PROJECT-23790762
[Journal Article] The influence of pioglitazone on the plasma amino acids profile in patients with Nonalcoholic Steatohepatitis (NASH)2012
- Author(s)
  Kakazu E, Kondo Y, Ninomiya M, Kimura O, Nagasaki F, Ueno Y, Shimosegawa T.
- Journal Title
  
  Hepatology International
  
  Volume: 2012 Issue: 2 Pages: 577-585
- DOI
  10.1007/s12072-012-9395-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790761, KAKENHI-PROJECT-23790762
[Journal Article] Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+circulating monocytes in patients with advanced cirrhosis2011
- Author(s)
  E. Kakazu, Y. Ueno, Y. Kondo, J. Inoue, M. Ninomiya, O. Kimura, Y. Wakui, K. Fukushima, K. Tamai, T. Shimosegawa
- Journal Title
  
  PLoS One
  
  Volume: 6 Issue: 8 Pages: 23402-23402
- DOI
  10.1371/journal.pone.0023402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790630, KAKENHI-PROJECT-23790761, KAKENHI-PROJECT-23790762
[Journal Article] 肝硬変に出現する血漿アミノ酸不均衡が免疫機構に与える影響について2011
- Author(s)
  嘉数英二　上野義之　下瀬川徹
- Journal Title
  
  肝胆膵
  
  Volume: 63(3) Pages: 375-382
- Data Source
  KAKENHI-PROJECT-23790762
[Journal Article] Rapid Reduction of HCV-Core protein in the peripheral blood improve the immunological response in Chronic Hepatitis C patients2011
- Author(s)
  Yasuteru Kondo, Yoshiyuki Ueno, Yuta Wakui et al.
- Journal Title
  
  Hepatology Research
  
  Volume: 41(12) Issue: 12 Pages: 1153-1168
- DOI
  10.1111/j.1872-034x.2011.00878.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790761, KAKENHI-PROJECT-23790762
[Journal Article] Enhanced replication of hepatitis B virus with frameshift in the precore region found in fulminant hepatitis patients2011
- Author(s)
  Inoue, J., Ueno, Y., Wakui, Y., Fukushima, K., Kondo, Y., Kakazu, E., Ninomiya, M., Niitsuma, H., and Shimosegawa, T.
- Journal Title
  
  The Journal of infectious diseases
  
  Volume: 204 Issue: 7 Pages: 1017-1025
- DOI
  10.1093/infdis/jir485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790762
[Journal Article] Plasma L-Cystine / L-Glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis.2011
- Author(s)
  Kakazu E, Ueno Y, Kondo Y, Inoue J, Ninomiya M, Kimura O, Wakui Y, Fukushima K, Tamai K, Shimosegawa T.
- Journal Title
  
  PLoS One
  
  Volume: 6(8)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790762
[Journal Article] Lymphotropic HCV strain can infect human primary naive CD4+ cells and affect their proliferation and IFN-γ secretion activity.2011
- Author(s)
  Kondo Y, Ueno Y, Kakazu E, Kobayashi K, Shiina M, Tamai K, Machida K, Inoue J, Wakui Y, Fukushima K, Obara N, Kimura O, Shimosegawa T.
- Journal Title
  
  J Gastroenterol. 46(2)
  
  Pages: 232-241
- NAID
  10029027386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] The Nutritional Index 'CONUT' Is Useful for Predicting Long-Term Prognosis of Patients with End-Stage Liver Diseases2011
- Author(s)
  Fukushima, K., Ueno, Y., Kawagishi, N., Kondo, Y., Inoue, J., Kakazu, E., Ninomiya, M., Wakui, Y., Saito, N., Satomi, S., and Shimosegawa, T.
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 224 Issue: 3 Pages: 215-219
- DOI
  10.1620/tjem.224.215
- NAID
  10029051173
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790762
[Journal Article] Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines.2010
- Author(s)
  Kimura O, Takahashi T, Ishii N, Inoue Y, Ueno Y, Kogure T, Fukushima K, Shiina M, Yamagiwa Y, Kondo Y, Inoue J, Kakazu E, Iwasaki T, Kawagishi N, Shimosegawa T, Sugamura K.
- Journal Title
  
  Cancer Sci 101
  
  Pages: 2145-2155
- NAID
  10027832222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] Inhibitory effect on hepatitis B virus in vitro by a peroxisome proliferator-activated receptor-gamma ligand2010
- Author(s)
  Wakui Y, Inoue J, Ueno Y, Fukushima K, Kondo Y, Kakazu E, Obara N, Kimura O, Shimosegawa T.
- Journal Title
  
  rosiglitazone.Biochem Biophys Res Commun 396
  
  Pages: 508-514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein.2010
- Author(s)
  Tamai K, Tanaka N, Nakano T, Kakazu E, Kondo Y, Inoue J, Shiina M, Fukushima K, Hoshino T, Sano K, Ueno Y, Shimosegawa T, Sugamura K.
- Journal Title
  
  Biochem Biophys Res Commun 399
  
  Pages: 384-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes.2010
- Author(s)
  Kondo Y, Ueno Y, Kobayashi K, Kakazu E, Shiina M, Inoue J, Tamai K, Wakui Y, Tanaka Y, Ninomiya M, Obara N, Fukushima K, Ishii M, Kobayashi T, Niitsuma H, Kon S, Shimosegawa T.
- Journal Title
  
  J Infect Dis 202
  
  Pages: 202-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] 肝硬変患者の免疫機構に関与する遊離アミノ酸の研究2010
- Author(s)
  嘉数英二
- Journal Title
  
  東北医学会雑誌
  
  Volume: 122巻 Pages: 30-32
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] 肝硬変患者の免疫機構に関与する遊離アミノ酸の研究2010
- Author(s)
  嘉数英二
- Journal Title
  
  東北医学会雑誌 122巻
  
  Pages: 30-32
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice.2010
- Author(s)
  Obara N, Fukushima K, Ueno Y, Wakui Y, Kimura O, Tamai K, Kakazu E, Inoue J, Kondo Y, Ogawa N, Sato K, Tsuduki T, Ishida K, Shimosegawa T.
- Journal Title
  
  J Hepatol 53
  
  Pages: 326-334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan.2009
- Author(s)
  Inoue J, Ueno Y, Nagasaki F, Akahane T, Fukushima K, Kogure T, Kondo Y, Kakazu E, Tamai K, Kido O, Nakagome Y, Ninomiya M, Obara N, Wakui Y, Takahashi M, Okamoto H, Shimosegawa T.
- Journal Title
  
  J Gastroenterol 44
  
  Pages: 329-337
- NAID
  10025174367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] 非代償性肝硬変におけるアミノ酸 imbalance が免疫機構に及ぼす影響2009
- Author(s)
  嘉数英二, 上野義之, 近藤泰輝, 下瀬川徹
- Journal Title
  
  消化器科 49
  
  Pages: 190-196
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] 肝硬変でのアミノ酸代謝異常が樹状細胞に与える影響2009
- Author(s)
  嘉数英二, 上野義之, 菅野記豊, 下瀬川徹
- Journal Title
  
  肝・胆・膵 58巻2号
  
  Pages: 247-254
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis.2009
- Author(s)
  Kakazu E, Ueno Y, Kondo Y, Fukushima K, Shiina M, Inoue J, Tamai K, Ninomiya M, Shimosegawa T.
- Journal Title
  
  Hepatology 50
  
  Pages: 1936-1945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] 非代償性肝硬変で出現する血漿アミノ酸 imbalance は樹状細胞成熟化を抑制し、分岐鎖アミノ酸(BCAA)により改善する2009
- Author(s)
  嘉数英二, 上野義之, 近藤泰輝, 下瀬川徹
- Journal Title
  
  薬理と治療 37
  
  Pages: 93-96
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] 非代償性肝硬変におけるアミノ酸imbalanceが免疫機構に及ぼす影響2009
- Author(s)
  嘉数英二, 上野義之, 近藤泰輝, 下瀬川徹
- Journal Title
  
  消化器科 Vol.49 No.2
  
  Pages: 190-196
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis2009
- Author(s)
  Kakazu E, Ueno Y, Kondo Y, Fukushima K, Shiina M, Inoue J, Tamai K, Ninomiya M, Shimosegawa T.
- Journal Title
  
  Hepatology 50
  
  Pages: 1936-1945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] 肝硬変でのアミノ酸代謝異常が樹状細胞に与える影響2009
- Author(s)
  嘉数英二, 上野義之, 菅野記豊, 下瀬川徹
- Journal Title
  
  肝・胆・膵 58
  
  Pages: 247-254
- Data Source
  KAKENHI-PROJECT-21790643
[Journal Article] 非代償性肝硬変で出現する血漿アミノ酸imbalanceは樹状細胞成熟化を抑制し2009
- Author(s)
  嘉数英二, 上野義之, 近藤泰輝, 下瀬川徹
- Journal Title
  
  分岐鎖アミノ酸(BCAA)により改善する「薬理と治療」 VOL 37
  
  Pages: 93-98
- Data Source
  KAKENHI-PROJECT-21790643
[Patent] 肝脂肪低減剤2018
- Inventor(s)
  嘉数英二
- Industrial Property Rights Holder
  嘉数英二
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K09336
[Presentation] フマル酸ジメチルの酸化ストレス応答機構 Keap1-Nrf2系を介した NASH 進展抑制効果2022
- Author(s)
  嘉数英二　美野正彰　考藤達哉
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08322
[Presentation] フマル酸ジメチルのNrf2活性化によるNASH進展抑制効果と肝細胞内アミノ酸代謝に与える影響2022
- Author(s)
  嘉数英二　美野正彰　佐野晃俊　阪田敏聖　筒井由梨子　吉川詩織　山添太士　森　泰三　由雄祥代　考藤達哉
- Organizer
  第30回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-20K08322
[Presentation] 代謝性肝疾患研究のための生体内栄養環境反映多臓器培養の試み2022
- Author(s)
  嘉数英二　美野正彰　考藤達哉
- Organizer
  第44回　日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-20K08322
[Presentation] 代謝異常関連脂肪性肝疾患 (MAFLD) におけるペマフィブラートおよび各種代謝関連薬の効果の検討2022
- Author(s)
  佐野晃俊、井上　淳、嘉数英二、二宮匡史、岩田朋晃、鶴岡未央、佐藤公亮、小貫真純、澤橋里子、正宗　淳
- Organizer
  第8回肝臓と糖尿病・代謝研究会
- Data Source
  KAKENHI-PROJECT-20K08322
[Presentation] 代謝関連脂肪性肝疾患（MAFLD）患者に対するピオグリタゾン及びSGLT2阻害薬の病態改善効果の比較検討2022
- Author(s)
  美野正彰　嘉数英二　佐野晃俊　青木孝彦　今村雅俊　由雄祥代　考藤達哉
- Organizer
  第44回　日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-20K08322
[Presentation] 脂肪変性肝細胞のVLDL放出における酸化ストレス応答と遊離アミノ酸の関係2021
- Author(s)
  嘉数英二、佐野晃俊、正宗淳
- Organizer
  第7回肝臓と糖尿病・代謝研究会　シンポジウム３
- Invited
- Data Source
  KAKENHI-PROJECT-20K08322
[Presentation] Hepatitis B virus infection affects expression of a small GTPase Rab5B resulting in the alteration of viral release2020
- Author(s)
  Jun Inoue, Masashi Ninomiya, Kosuke Sato, Eiji Kakazu, Tomoaki Iwata, Akitoshi Sano, Mio Tsuruoka, Atsushi Masamune
- Organizer
  AASLD The Liver Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08385
[Presentation] Steatotic hepatocytes release mature very-low-density lipoprotein via methionine and tyrosine metabolism in a Keap1-Nrf2 dependent manner.2020
- Author(s)
  Akitoshi Sano, Eiji Kakazu, Jun Inoue, Masashi Ninomiya, Tomoaki Iwata, Mio Tsuruoka, Kosuke Sato, Atsushi Masamune.
- Organizer
  米国肝臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08322
[Presentation] Decreased L-methionine / L-tyrosine in portal blood induces endoplasmic reticulum (ER) stress to hepatocytes via the suppression of lipid secretion in non-alcoholic fatty liver disease (NAFLD)2018
- Author(s)
  Akitoshi Sano, Eiji Kakazu, Tatsuki Morosawa, Jun Inoue, Masashi Ninomiya, Tomoaki Iwata, Satoshi Takai, Takuya Nakamura, Tooru Shimosegawa, Atsushi Masamune
- Organizer
  アメリカ肝臓学会年次集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09336
[Presentation] 各種慢性肝疾患の肝予備能と血漿遊離アミノ酸プロファイル2018
- Author(s)
  嘉数英二　佐野晃俊　諸沢樹　井上淳　二宮匡史　岩田朋晃　梅津輝行　高井智　中村琢也　正宗　淳下瀬川徹
- Organizer
  第104回　消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09336
[Presentation] 門脈血類似灌流培養による肝細胞脂肪変性に関与する遊離アミノ酸の検討2018
- Author(s)
  佐野晃俊、嘉数英二、井上淳、二宮匡史、岩田朋晃、梅津輝行、高井智、中村琢也、正宗淳、下瀬川徹
- Organizer
  第54回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K09336
[Presentation] The relationship between serum albumin and plasma-branched chain amino acids (pBCAAs) in recent chronic liver disease: a single-center retrospective study.2018
- Author(s)
  Eiji Kakazu, Akitoshi Sano, Tatsuki Morosawa, Jun Inoue, Masashi Ninomiya, Tomoaki Iwata, Satoshi Takai, Takuya Nakamura, Tooru Shimosegawa, Atsushi Masamune
- Organizer
  FALK symposium 212
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09336
[Presentation] The relationship between the plasma free amino acids and the pathological features in nonalcoholic fatty liver disease (NAFLD).2017
- Author(s)
  Eiji Kakazu, Akitoshi Sano, Tatsuki Morosawa, Jun Inoue, Takayuki Kogure, Masashi Ninomiya, Tomoaki Iwata, Teruyuki Umetsu, Takuya Nakamura, Satoshi Takai, Tooru Shimosegawa
- Organizer
  アメリカ肝臓学会 annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09336
[Presentation] 門脈血類似・三次元潅流培養による肝細胞に対する脂肪毒性と小胞体ストレスの評価2017
- Author(s)
  嘉数英二、佐野晃俊、井上　淳、小暮高之、二宮匡史、諸沢　樹、梅津輝行、高井　智、中村琢也、岩田朋晃、下瀬川徹
- Organizer
  肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K09336
[Presentation] 非アルコール性脂肪酸肝炎においてパルミチン酸はIRE1a / XBP1 依存性に肝細胞から細胞外顆粒を放出させ、マクロファージを集積させる2016
- Author(s)
  嘉数英二、Harmeet malhi、下瀬川徹
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ幕張（千葉県千葉市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K09336
[Presentation] 末梢血中遊離アミノ酸を用いた非アルコール性脂肪性肝疾患・肝炎（NAFLD / NASH）の線維化予測式の検討2016
- Author(s)
  嘉数英二、諸沢樹、下瀬川徹
- Organizer
  第41回日本肝臓学会東部会
- Place of Presentation
  京王プラザホテル（新宿区　東京）
- Year and Date
  2016-12-08
- Data Source
  KAKENHI-PROJECT-16K09336
[Presentation] Profiling of hepatic portal blood metabolites in Non-alcoholic fatty liver disease mice by capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS)2016
- Author(s)
  Eiji Kakazu, Harmeet Malhi, Jun Inoue, Masashi Ninomiya, Takayuki Kogure, Tooru Shimosegawa
- Organizer
  Asian Pacific Digestive Week
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2016-10-04
- Data Source
  KAKENHI-PROJECT-16K09336
[Presentation] The evaluation of endoplasmic reticulum (ER) stress in hepatocytes under a new 3D perfusion culture system consistent with hepatic portal blood.2016
- Author(s)
  Eiji Kakazu, Jun Inoue, Takayuki Kogure, Masashi Ninomiya, Tatsuki Morosawa, Teruyuki Umetsu, Takuya Nakamura, Satoshi Takai, Tooru Shimosegawa
- Organizer
  American Association for the Study of Liver Diseases
- Place of Presentation
  John B. Hynes Veterans Memorial Convention Center（ボストン　米国）
- Year and Date
  2016-11-13
- Data Source
  KAKENHI-PROJECT-16K09336
[Presentation] Hepatocytes Release Ceramide-rich Proinflammatory Extracellular Vesicles in an IRE1alpha-dependent manner2015
- Author(s)
  Eiji Kakazu, Amy S. Mauer, Harmeet Malhi
- Organizer
  アメリカ肝臓学会
- Place of Presentation
  米国（サンフランシスコ）
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460972
[Presentation] 肝細胞癌に誘導されたMyeloid-Derived Suppressor Cells(MDSCs)とPD-L1発現の関係2013
- Author(s)
  岩田朋晃, 近藤泰輝, 木村修, 二宮匡史, 小暮高之, 嘉数英二, 諸沢樹, 下瀬川徹
- Organizer
  日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460970
[Presentation] The tricarboxylic acid (TCA) cycle of dendritic cells was disturbed by imbalance of plasma amino acid observed in cirrhosis.2013
- Author(s)
  Eiji Kakazu, Yasuteru Kondo, Takayuki Kogure, Masashi Ninomiya, Osamu Kimura, Tatsuki Morosawa, Tomoaki Iwata, Yoshiyuki Ueno, Tooru Shimosegawa
- Organizer
  The American Association for the Study of Liver Diseases
- Place of Presentation
  Washington dc, USA
- Data Source
  KAKENHI-PROJECT-25460972
[Presentation] アンチセンスオリゴヌクレオチドを用いたmiR-221発現抑制による肝癌増殖制御　同所移植マウス肝癌モデルを用いたin vivo研究2013
- Author(s)
  小暮高之, 近藤泰輝, 嘉数英二, 二宮匡史, 木村修, 岩田朋晃, 諸沢樹, 岩崎隆雄, 下瀬川徹
- Organizer
  日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460970
[Presentation] An appropriate amount of Sorafenib could suppress the myeloid derived suppressor cells (MDSC) and Tregs in HCC patients2013
- Author(s)
  Kondo Y, Iwata T, Kimura O, Ninomiya M, Morosawa T, Kakazu E, Kogure T, Shimosegawa T
- Organizer
  AASLD Annual Meeting
- Place of Presentation
  ワシントン　D.C.　アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-25460970
[Presentation] 肝硬変に出現する血漿アミノ酸不均衡が樹状細胞機能を抑制するメカニズム2013
- Author(s)
  嘉数英二、　諸沢　樹、　近藤泰輝、　小暮高之、　二宮匡史、　木村　修、　岩田朋晃、　下瀬川徹
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460972
[Presentation] An imbalance in plasma amino acids of advanced cirrhotic patients suppresses dendritic cells maturation by disturbing the mitochondrial TCA cycle.2013
- Author(s)
  Eiji Kakazu, Yasuteru Kondo, Takayuki Kogure, Masashi Ninomiya, Osamu Kimura, Tatsuki Morosawa, Tomoaki Iwata, Yoshiyuki Ueno, Tooru Shimosegawa
- Organizer
  Asian Pacific Association for The Study of the Liver
- Place of Presentation
  Suntec City, Singapore
- Data Source
  KAKENHI-PROJECT-25460972
[Presentation] 非アルコール性脂肪性肝炎（NASH）に対するpioglitazoneの治療効果と血漿アミノ酸濃度に与える影響2012
- Author(s)
  嘉数英二
- Organizer
  第39回日本肝臓学会東部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790762
[Presentation] Pioglitazoneの非アルコール性脂肪性肝炎（NASH）に対する治療効果と血漿アミノ酸濃度に与える影響2012
- Author(s)
  嘉数英二
- Organizer
  第20回　日本消化器関連学会週間
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790762
[Presentation] An imbalance in plasma amino acids of advanced cirrhotic patients suppresses the maturation of dendritic cells by reducing the intracellular ATP due to interference with the mitochondrial TCA cycle.2012
- Author(s)
  Eiji Kakazu
- Organizer
  The American Association for the Study of Liver Diseases (AASLD) anual meeting
- Place of Presentation
  boston, USA
- Data Source
  KAKENHI-PROJECT-23790762
[Presentation] The influence of pioglitazone on the plasma amino acids profile in patients with nonalcoholic steatohepatitis (NASH).2012
- Author(s)
  Eiji Kakazu
- Organizer
  The American Association for the Study of Liver Diseases (AASLD) anual meeting
- Place of Presentation
  boston, USA
- Data Source
  KAKENHI-PROJECT-23790762
[Presentation] The influence of pioglitazone on the plasma amino acids profile in patients with nonalcoholic steatohepatitis (NASH).2012
- Author(s)
  嘉数英二
- Organizer
  第４８回日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23790762
[Presentation] 非代償性肝硬変で出現する L-Cystine/L-Glutamic acid不均衡はLPS刺激時の単球からのTNF-α産生を高め腎機能低下に関与する2011
- Author(s)
  嘉数英二上野義之近藤泰輝福島耕治井上淳二宮匡史涌井祐太岩崎隆雄下瀬川徹
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-23790762
[Presentation] 非代償性肝硬変に出現する血漿 L-Cystine/ L-Glutamate不均衡はCD14+単球内の還元型グルタチオンを低下させ炎症性サイトカインを増加させる2011
- Author(s)
  嘉数英二上野義之近藤泰輝福島耕治井上淳二宮匡史木村修岩崎隆雄下瀬川徹
- Organizer
  JDDW
- Place of Presentation
  福岡
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-23790762
[Presentation] Plasma L-Cystine / L-Glutamate imbalance increases tumor necrosis factor-alpha from circulating monocytes via system Xc- (4F2hc+xCT) in patients with advanced cirrhosis2011
- Author(s)
  EIJI KAKAZU, YOSHIYUKI UENO, YASUTERU KONDO, JUN INOUE, MASASHI NINOMIYA, OSAMU KIMURA, TOORU SHIMOSEGAWA
- Organizer
  AASLD
- Place of Presentation
  San Francisico, USA
- Year and Date
  2011-11-07
- Data Source
  KAKENHI-PROJECT-23790762
[Presentation] 非代償性肝硬変に出現する血漿中 L-Cystine / L-Glutamate 不均衡は交換輸送体 xCT を介してCD14+単球からの炎症性サイトカイン産生を増加させる2011
- Author(s)
  嘉数英二上野義之近藤泰輝福島耕治井上淳二宮匡史木村修小原範之涌井祐太岩崎隆雄下瀬川徹
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-23790762
[Presentation] Branched-chain amino acids improve the maturation of dendritic cells in patients with advanced cirrhosis ex vivo.2010
- Author(s)
  EIJI KAKAZU, YOSHIYUKI UENO, YASUTERU KONDO, KOJI FUKUSHIMA, MASAAKI SHIINA YOKO YAMAGIWA, JUN INOUE, KEIICHI TAMAI, NORIYUKI OBARA, OSAMU KIMURA, YUTA WAKUI TOORU SHIMOSEGAWA
- Organizer
  APASL
- Place of Presentation
  北京
- Data Source
  KAKENHI-PROJECT-21790643
[Presentation] L-cystineはLPS刺激時の単球からのTNF-α産生を高め2010
- Author(s)
  嘉数英二, 上野義之, 近藤泰輝, 福島耕治, 井上淳, 二宮匡史, 涌井祐太, 岩崎隆雄, 下瀬川徹
- Organizer
  非代償性肝硬変の腎機能低下に関与するJDDW
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21790643
[Presentation] An imbalance in plasma amino acids of advaced cirrhotic patients impairs the maturation of dendritic cells via mTOR/S6K signaling pathway.2010
- Author(s)
  EIJI KAKAZU, YOSHIYUKI UENO, YASUTERU KONDO, KOJI FUKUSHIMA, MASAAKI SHIINA, YOKO YAMAGIWA, JUN INOUE, KEIICHI TAMAI, TOORU SHIMOSEGAWA
- Organizer
  APASL
- Place of Presentation
  香港
- Data Source
  KAKENHI-PROJECT-21790643
[Presentation] L-CystineはLPS刺激時の単球からのTNF-α産生を高め、非代償性肝硬変の腎機能低下に関与する2010
- Author(s)
  嘉数英二
- Organizer
  第18回日本消化器病関連学会週間
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-21790643
[Presentation] 非代償性肝硬変のアミノ酸インバランスが樹状細胞成熟化に及ぼす影響について2009
- Author(s)
  嘉数英二
- Organizer
  肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21790643
[Presentation] 分岐鎖アミノ酸(BCAA)の樹状細胞成熟化に対する影響とBCAA製剤内服後の血行動態が末梢血単核球に与える影響について2009
- Author(s)
  嘉数英二, 上野義之, 近藤泰輝, 福島耕治, 山極洋子, 椎名正明, 井上淳, 玉井恵一, 二宮匡史城戸治, 中込悠, 小原範之, 木村修, 涌井祐太, 岩崎隆雄, 下瀬川徹
- Organizer
  肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-21790643
[Presentation] Hepatoma with HBV replication could attract CX3CR1+ NKG2Dlow NK cells and CX3CR1+PD-1+ CD8+ T cells
- Author(s)
  Yasuteru Kondo, Osamu Kimura, Tomoaki Iwata, Tatsuki Morosawa, Masashi Ninomiya, Eiji Kakazu, Takayuki Kogure, Yasuhito Tanaka, Tooru Shimosegawa
- Organizer
  DDW
- Place of Presentation
  シカゴ、米国
- Year and Date
  2014-05-03 – 2014-05-06
- Data Source
  KAKENHI-PROJECT-25460970
[Presentation] 非代償性肝硬変に出現する血漿中L-Cystine / L-Glutamate不均衡は交換輸送体xCTを介してCD14+単球からの炎症性サイトカイン産生を増加させる。
- Author(s)
  嘉数英二　上野義之　近藤泰輝　福島耕治　井上淳　二宮匡史　木村修　　小原範之　涌井祐太　岩崎隆雄　下瀬川徹
- Organizer
  第４７回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790762
[Presentation] Metabolomics of hepatic portal blood in Non-alcoholic fatty liver disease mice by capillary electrophoresis time-of-flight mass spectrometry
- Author(s)
  嘉数英二
- Organizer
  米国消化器病週間 2015
- Place of Presentation
  ワシントン　米国
- Year and Date
  2015-05-17 – 2015-05-19
- Data Source
  KAKENHI-PROJECT-25460972
[Presentation] 非代償性肝硬変で出現するL-Cystine / L-Glutamic acid不均衡はLPS刺激時の単球からのTNF-α産生を高め、腎機能低下に関与する
- Author(s)
  嘉数英二　上野義之　近藤泰輝　福島耕治　井上淳　二宮匡史　涌井祐太　岩崎隆雄　下瀬川徹
- Organizer
  第９７回日本消化器病学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790762
[Presentation] 非代償性肝硬変に出現する血漿L-Cystine / L-Glutamate不均衡はCD14+単球内の還元型グルタチオンを低下させ炎症性サイトカインを増加させる
- Author(s)
  嘉数英二　　上野義之　近藤泰輝　福島耕治　井上　淳　二宮匡史　木村　修　岩崎隆雄　下瀬川徹
- Organizer
  第１９回日本消化器関連学会週間
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790762
[Presentation] Plasma L-Cystine / L-Glutamate imbalance increases tumor necrosis factor-alpha from circulating monocytes via system Xc- (4F2hc+xCT) in patients with advanced cirrhosis.
- Author(s)
  EIJI KAKAZU, YOSHIYUKI UENO, YASUTERU KONDO, JUN INOUE, MASASHI NINOMIYA, OSAMU KIMURA, TOORU SHIMOSEGAWA
- Organizer
  The 62nd annual meeting of the american association for the study of liver disease (AASLD)
- Place of Presentation
  米国　サンフランシスコ
- Data Source
  KAKENHI-PROJECT-23790762

1. KOGURE Takayuki (70400330)

# of Collaborated Projects: 7 results

# of Collaborated Products: 17 results
2. Kondo Yasuteru (70455822)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
3. Inoue Jun (60455821)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 高橋賢治 (00736332)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 岩田朋晃 (30803647)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. 二宮匡史 (70583938)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. 佐藤麻理 (20846018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 濱田晋 (20451560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. NIIHORI Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. TAMAI Keiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. SHIINA Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 松原洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 長嶋剛史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 山添太士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 上野義之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAKAZU EIJI 嘉数 英二

KAKAZU Eiji 嘉数 英二

Research Projects

Research Products

Co-Researchers

Exploring the Relationship between Intra- and Extracellular Free Amino Acid Imbalance and Mitochondrial TCA Cycle Function in HepatocytesPrincipal Investigator

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肝癌のチロシンキナーゼ阻害薬に対する耐性獲得機序の解明と耐性克服薬の探索

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Impact of free amino acids on intracellular stress response mechanisms in hepatic steatosis.Principal Investigator

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Mechanistic analysis of hepatitis B virus infection focusing on vesicle trafficking system and its clinical application

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Analysis of the mechanism of tumor microenvironment modulation through exosomes in hepatocellular cancer stem cells

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Elucidation of the association between non alcoholic steatohepatitis and endoplasmic reticulum stress by metabolomics of portal bloodPrincipal Investigator

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Development of HCC treatment by analyzing the induction of MDSC, TAM and Tregs

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Exosomal transfer of functional RNA in hepatocellular carcinoma cell proliferation

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amino acids metabolism and immune abnormality in non alcoholic steatohepatitisPrincipal Investigator

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The plasma L-Cystine / L-Glutamate imbalance in cirrhosis influences the function of antigen-presenting cell.Principal Investigator

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The study of amino acids imbalance which influences the immune cells, especially dendritic cells, in patients with advanced cirrhosis.Principal Investigator

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[Journal Article] Effects of sodium glucose cotransporter 2 inhibitors and pioglitazone on FIB‐4 index in metabolic‐associated fatty liver disease2023

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[Journal Article] Steatotic hepatocytes release mature VLDL via methionine and tyrosine metabolism in a Keap1‐Nrf2 dependent manner2021

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KAKAZU EIJI 嘉数英二

KAKAZU Eiji 嘉数英二