Abe Yasuhiro 阿部康弘

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ABE Yasuhiro 阿部康弘

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Researcher Number	20509898
Other IDs
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 薬品部, 室長
Affiliation (based on the past Project Information) *help	2011: 独立行政法人医薬基盤研究所, 創薬基盤研究部・バイオ創薬プロジェクト, 研究員 2009 – 2011: National Institute of Biomedical Innovation, 創薬基盤研究部バイオ創薬プロジェクト, 研究員 2008: National Institute of Biomedical Innovation, 基盤的研究部創薬プロテオミクスアロジェクト, 研究員
Review Section/Research Field	Principal Investigator Medical pharmacy
Keywords	Principal Investigator ファージ表面提示法 / インターフェロン / サイトカイン / 免疫誘導療法 / バイオコンジュゲーション / アンタゴニスト / 自己免疫疾患 / 蛋白質

Development of Immunomodulatory Cytokine mutantsPrincipal Investigator
- Principal Investigator
  
  ABE Yasuhiro
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  独立行政法人医薬基盤研究所
Development of functional mutant protein with antagonistic activity as an anti-inflammatory drugPrincipal Investigator
- Principal Investigator
  
  ABE Yasuhiro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Biomedical Innovation

All 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Development of a novel antibody proteomics system using a phage antibody library for efficient screening of tumor-related biomarker proteins.2011
- Author(s)
  Imai S., Nagano K., Yoshida Y., Okamura T., Yamashita T., Abe Y., Yoshikawa T., Yoshioka Y., Kamada H., Mukai Y., Nakagawa S., Tsutsumi Y., Tsunoda S.
- Journal Title
  
  Biomaterials
  
  Volume: 32(1) Pages: 162-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790180
[Journal Article] Development of a novel antibody proteomics system using a phage antibody library for efficient screening of tumor-related biomarker proteins2011
- Author(s)
  Imai S, Nagano K, Yoshida Y, Okamura T, Yamashita T, Abe Y, Yoshikawa T, Yoshioka Y, Kamada H, Mukai Y, Nakagawa S, Tsutsumi Y, Tsunoda S
- Journal Title
  
  Biomaterials
  
  Volume: 32 Issue: 1 Pages: 162-169
- DOI
  10.1016/j.biomaterials.2010.09.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790104, KAKENHI-PROJECT-22790180
[Journal Article] Fine tuning of receptor-selectivity for tumor necrosis factor-a using a phage display system with one-step competitive panning2011
- Author(s)
  Abe Y, Yoshikawa T, et al
- Journal Title
  
  Biomaterials
  
  Volume: 32(23) Issue: 23 Pages: 5498-5504
- DOI
  10.1016/j.biomaterials.2011.04.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390046, KAKENHI-PROJECT-22790104, KAKENHI-PROJECT-22790180
[Journal Article] Creation of TNFR1-selective antagonist and its therapeutic effects.2010
- Author(s)
  Nomura T., Abe Y., Yoshioka Y., Nakagawa S., Tsunoda S., Tsutsumi Y.
- Journal Title
  
  Yakugaku Zasshi 130(1)
  
  Pages: 63-8
- NAID
  130000152012
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article]2010
- Author(s)
  Nomura T., Abe Y., Yoshioka Y., Nakagawa S., Tsunoda S., Tsutsumi Y
- Journal Title
  
  Yakugaku Zasshi 130(1)
  
  Pages: 63-8
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] The IL-1 family cytokines as mucosal vaccine adjuvant for the induction of protective immunity against influenza virus.2010
- Author(s)
  Kayamuro H., Yoshioka Y., Abe Y., Arita S., Katayama K., Nomura T., Yoshikawa T., Kubota-Koketsu R., Ikuta K., Okamoto S., Mori Y., Kunisawa J., Kiyono H., Itoh N., Nagano K., Kamada H., Tsutsumi Y., Tsunoda S.
- Journal Title
  
  J.Virol.
  
  Volume: 84(24) Pages: 12703-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790180
[Journal Article] The IL-1 family cytokines as mucosal vaccine adjuvant for the induction of protective immunity against influenza virus2010
- Author(s)
  Kayamuro H., Yoshioka Y., Abe Y., Arita S., Katayama K., Nomura T., Yoshikawa T., Kubota-Koketsu R., Ikuta K., Okamoto S., Mori Y., Kunisawa J., Kiyono H., Itoh N., Nagano K., Kamada H., Tsutsumi Y., Tsunoda S.
- Journal Title
  
  J Virol.
  
  Volume: 84(24) Issue: 24 Pages: 12703-12
- DOI
  10.1128/jvi.01182-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790180
[Journal Article] Creation of an improved mutant TNF with TNFR1-selectivity and antagonisitic activity by phage display technology.2010
- Author(s)
  Nomura T., Abe Y., Kamada H., Inoue M., Kawara T., Arita S., Furuya T., Minowa K., Yoshioka Y., Shibata H., Kayamuro H., Yamashita T., Nagano K., Yoshikawa T., Mukai Y., Nakagwa S., Tsunoda S., Tsutsumi Y.
- Journal Title
  
  Pharmazie 65(2)
  
  Pages: 93-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology2010
- Author(s)
  Nomura T., Abe Y., Kamada H., Inoue M., Kawara T., Arita S., Furuya T., Minowa K., Yoshioka Y., Shibata H., Kayamuro H., Yamashita T., Nagano K., Yoshikawa T., Mukai Y., Nakagawa S., Tsunoda S., Tsutsumi Y
- Journal Title
  
  Pharmazie 65(2)
  
  Pages: 93-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] Novel protein engineering strategy for creating highly receptor-selective mutant TNFs2009
- Author(s)
  Nomura T., Abe Y., Kamada H., Inoue M., Kawara T., Arita S., Furuya T., Yoshioka Y., Shibata H., Kayamuro H., Yamashita T., Nagano K., Yoshikawa T., Mukai Y., Nakagawa S., Taniai M., Ohta T., Tsunoda S., Tsutsumi Y
- Journal Title
  
  Biochem. Biophys. Res. Commun 388(4)
  
  Pages: 667-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] Novel protein engineering strategy for creating highly receptor-selecive mutant TNFs.2009
- Author(s)
  Nomura T., Abe Y., Kamada H., Inoue M., Kawara T., Arita S., Furuya T., Yoshioka Y., Shibata H., Kayamuro H., Yamashita T., Nagano K., Yoshikawa T., Mukai Y., Nakagawa S., Taniai M., Ohta T., Tsunoda S., Tsutsumi Y.
- Journal Title
  
  Biochem Biophys Res Commun 388(4)
  
  Pages: 667-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant2009
- Author(s)
  Mukai Y, Shibata H, Nakamura T, Yoshioka Y, Abe Y, Nomura T, Taniai M, Ohta T, Ikemizu S, Nakagawa S, Tsunoda S, Kamada H, Yamagata Y, Tsutsumi Y
- Journal Title
  
  Journal of Molecular Biology 385
  
  Pages: 1221-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] Development of novel DDS technologies for optimized protein therapy by creating functional mutant proteins with antagonistic activity2009
- Author(s)
  Abe Y
- Journal Title
  
  Yakugaku Zasshi 129(8)
  
  Pages: 933-939
- NAID
  130000135988
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] The specific effect of 2-Methoxyestradiol on lymphatic vascular endothelial cells2009
- Author(s)
  Imai S., Yoshida Y., Okamura T., Nagano K., Abe Y., Yoshikawa T., Kamada H., Nakagawa S., Tsunoda S., Tsutsumi Y
- Journal Title
  
  Pharmazie 64(3)
  
  Pages: 214-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF.2009
- Author(s)
  Shibata H., Yoshioka Y., Abe Y., Ohkawa A., Nomura T., Minowa K., Mukai Y., Nakagawa S., Taniai M., Ohta T., Tsunoda S., Kamada H., Tsutsumi Y.
- Journal Title
  
  Biomaterials 30(34)
  
  Pages: 6638-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] The specific effect of 2-methoxyestradiol on lymphatic vascular endothelial cells2009
- Author(s)
  Imai S, Yoshida Y, Okamura T, Nagano K, Abe Y, Yoshikawa T, Kamada H, Nakagawa S, Tsunoda S, Tsutsumi Y.
- Journal Title
  
  Pharmazie 64(3)
  
  Pages: 214-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant2009
- Author(s)
  Mukai Y., Shibata H., Nakamura T., Yoshioka Y., Abe Y., Nomura T., Taniai M., Ohta T., Ikemizu S., Nakagawa S., Tsunoda S., Kamada H., Yamagata Y., Tsutsumi Y
- Journal Title
  
  J. Mol. Biol 385
  
  Pages: 1221-1229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] The augmentation of intracellular delivery of peptide therapeutics by artificial protein transduction domains2009
- Author(s)
  Yoshikawa T, Sugita T, Mukai Y, Abe Y, Nakagawa S, Kamada H, Tsunoda SI, Tsutsumi Y.
- Journal Title
  
  Biomaterials (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] Development of novel DDS technologies for optimized protein therapy by creating functional mutant proteins with antagonistic activity.2009
- Author(s)
  Abe Y.
- Journal Title
  
  Yakugaku Zasshi 129(8)
  
  Pages: 933-9
- NAID
  130000135988
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF2009
- Author(s)
  Shibata H., Yoshioka Y., Abe Y., Ohkawa A., Nomura T., Minowa K., Mukai Y., Nakagawa S., Taniai M., Ohta T., Tsunoda S., Kamada H., Tsutsumi Y
- Journal Title
  
  Biomaterials 30(34)
  
  Pages: 6638-6647
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] The augmentation of intracellular delivery of peptide therapeutics by artificial protein transduction domains2009
- Author(s)
  Yoshikawa T., Sugita T., Mukai Y., Abe Y., Nakagawa S., Kamada H., Tsunoda S., Tsutsumi Y
- Journal Title
  
  Biomaterials 30(19)
  
  Pages: 3318-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] The therapeutic effect of TNFR1-selective antagonistic mutant TNF-αin murine hepatitis models2008
- Author(s)
  Shibata H., Yoshioka Y., Ohkawa A., Abe Y., Nomura T., Mukai Y., Nakagawa S., Taniai M., Ohta T., Mayumi T., Kamada H., Tsutsumi Y
- Journal Title
  
  Cytokine 44(2)
  
  Pages: 229-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] Organelle-targeted delivery of biological macromolecules using the protein transduction domain: Potential applications for peptide aptamer delivery into the nucleus2008
- Author(s)
  Yoshikawa T., Sugita T., Mukai Y., Yamanada N., Nagano K., Nabeshi H., Yoshioka Y., Nakagawa S., Abe Y., Kamada H., Tsunoda S., Tsutsumi Y
- Journal Title
  
  J. Mol. Biol 380(5)
  
  Pages: 777-782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] Simple and highly sensitive assay system for TNFR2-mediated soluble-and transmembrane-TNF activity2008
- Author(s)
  Abe Y., Yoshikawa T., Kamada H., Shibata H., Nomura T., Minowa K., Kayamuro H., Katayama K., Miyoshi H., Mukai Y., Yoshioka Y., Nakagawa S., Tsunoda S., Tsutsumi Y
- Journal Title
  
  J. Immunol. Methods 335(1-2)
  
  Pages: 71-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity2008
- Author(s)
  Abe Y, Yoshikawa T, Kamada H, Shibata H, Nomura T, Minowa K, Kayamuro H, Katayama K, Miyoshi H, Mukai Y, Yoshioka Y, Nakagawa S, Tsunoda S, Tsutsumi Y
- Journal Title
  
  Journal of Immunological Methods 335(1-2)
  
  Pages: 71-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] Effect of protein properties on display efficiency using the M13 phage display system2008
- Author(s)
  Imai S, Mukai Y, Takeda T, Abe Y, Nagano K, Kamada H, Nakagawa S, Tsunoda S, Tsutsumi Y.
- Journal Title
  
  Pharmazie 63(10)
  
  Pages: 760-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] The therapeutic effect of TNFR1-selective antagonistic mutant TNF-<alpha> in murine hepatitis models2008
- Author(s)
  Shibata H, Yoshioka Y, Ohkawa A, Abe Y, Nomura T, Mukai Y, Nakagawa S, Taniai M, Ohta T, Mayumi T, Kamada H, Tsutsumi Y
- Journal Title
  
  Cytokine 44(2)
  
  Pages: 229-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Journal Article] Organelle-targeted delivery of biological macromolecules using the protein transduction domain : potential applications for Peptide aptamer delivery into the nucleus2008
- Author(s)
  Yoshikawa T, Sugita T, Mukai Y, Yamanada N, Nagano K, Nabeshi H, Yoshioka Y, Nakagawa S, Abe Y, Kamada H, Tsunoda S, Tsutsumi Y.
- Journal Title
  
  Journal of Molecular Biology 380(5)
  
  Pages: 229-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890300
[Presentation] Selective inhibition of TNFR1 by mutant TNF with antagonistic activity is effective in the treatment of experimental autoimmune encephalomyelitis2011
- Author(s)
  Abe Y, Nomura T, Inoue M, Furuya T, Arita S, Nabeshi H, Yoshikawa T, Yoshioka Y, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
- Organizer
  13th International TNF Conference
- Place of Presentation
  Awaji (Japan)
- Data Source
  KAKENHI-PROJECT-22790180
[Presentation] Selective inhibition of TNFR1 by mutant TNF with antagonistic activity is effective in the treatment of experimental autoimmune encephalomyelitis2011
- Author(s)
  Abe Y., Nomura T., Inoue M., Furuya T., Arita S., Nabeshi H., Yoshikawa T., Yoshioka Y., Nagano K., Kamada H., Tsutsumi Y., Tsunoda S.
- Organizer
  13th International TNF Conference
- Place of Presentation
  Awaji(Japan)
- Data Source
  KAKENHI-PROJECT-22790180
[Presentation] Biological and structural characterization of human TNFR2-selective TNF mutants2011
- Author(s)
  Abe Y., Inoue M., Furuya T., Mukai Y., Nakamura T., Yamagata Y., Nabeshi H., Yoshikawa T., Yoshioka Y., Nagano K., Kamada H., Tsutsumi Y., Tsunoda S.
- Organizer
  9th Joint Meeting of ICS-ISICR(Cytokines2011)
- Place of Presentation
  Florence(Italy)
- Data Source
  KAKENHI-PROJECT-22790180
[Presentation] Biological and structural characterization of human TNFR2-selective TNF mutants2011
- Author(s)
  Abe Y, Inoue M, Furuya T, Mukai Y, Nakamura T, Yamagata Y, Nabeshi H, Yoshikawa T, Yoshioka Y, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
- Organizer
  9th Joint Meeting of ICS-ISICR (Cytokines2011)
- Place of Presentation
  Florence (Italy)
- Data Source
  KAKENHI-PROJECT-22790180
[Presentation] レセプター特異性に優れた機能性人工質蛋白質創出システムの開発2010
- Author(s)
  阿部康弘,井上雅己,野村鉄也,有田修平,古屋剛,長野一也,鎌田春彦,角田慎一,堤康央
- Organizer
  第26回日本DDS学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22790180
[Presentation] Evaluation of safety and efficacy of TNFR1-selective antagonistic mutant TNF as a novel anti-inflammatory drug2009
- Author(s)
  Abe Y., Shibata H., Nomura T., Kayamuro H., Yoshikawa T., Yoshioka Y., Nakagawa S., Kamada H., Tsunoda S., Tsutsumi Y
- Organizer
  Society of Toxicology 48th Annual Meeting, ToxExpo
- Place of Presentation
  Baltimore (U.S.A. )
- Data Source
  KAKENHI-PROJECT-20890300
[Presentation] Creation and X-ray structural analysis of TNFR1-selective mutant TNF with antagonistic activity.2009
- Author(s)
  Abe Y., Nomura T., Kayamuro H., Yoshioka Y., Kamada H., Tsunoda S., Tsutsumi Y.
- Organizer
  HUPO 8th Annual World Congress
- Place of Presentation
  Tronto(Canada)
- Data Source
  KAKENHI-PROJECT-20890300
[Presentation] Evaluation of safety and efficacy of TNFR1-selective antagonistic mutant TNF as a novel anti-inflammatory drug2009
- Author(s)
  Abe Y., Shibata H., Nomura T., Kayamuro H., Yoshikawa T., Yoshioka Y., Nakagawa S., Kamada H., Tsunoda S., Tsutsumi Y.
- Organizer
  Society of Toxicology 48th Annual Meeting & ToxExpo
- Place of Presentation
  Baltimore (U.S.A.)
- Data Source
  KAKENHI-PROJECT-20890300
[Presentation] Effective treatment of established murine collagen-induced arthritis with a novel TNFR1-selective antagonistic mutant TNF2009
- Author(s)
  Tsunoda S., Abe Y., Nomura T., Kayamuro H., Shibata H., Yoshioka Y., Tsutsumi Y.
- Organizer
  12th International TNF Conference
- Place of Presentation
  Madrid(Spain)
- Data Source
  KAKENHI-PROJECT-20890300
[Presentation] 創薬プロテオミクス研究を有効活用したバイオ創薬2009
- Author(s)
  阿部康弘, 角田慎一, 堤康央
- Organizer
  Cphl Japan 2009
- Place of Presentation
  東京
- Year and Date
  2009-04-21
- Data Source
  KAKENHI-PROJECT-20890300
[Presentation] アンタゴニスト活性を有したTNFR1指向性変異体の新規自己免疫疾患治療薬としての有用性評価.2009
- Author(s)
  阿部康弘, 鎌田春彦, 角田慎一, 堤康央
- Organizer
  第59回日本薬学会近畿支部給総会・大会
- Place of Presentation
  大阪
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20890300
[Presentation] Effective treatment of established murine collagen-induced arthritis with a novel TNFR1-selective antagonistic mutant TNF2009
- Author(s)
  Tsunoda S., Abe Y., Nomura T., Kayamuro H., Shibata H., Yoshioka Y., Tsutsumi Y
- Organizer
  12th International TNF Conference
- Place of Presentation
  Madrid (Spain)
- Data Source
  KAKENHI-PROJECT-20890300
[Presentation] アンタゴニスト活性を有したTNFR1指向性変異体の新規自己免疫疾患治療薬としての有用性評価2009
- Author(s)
  阿部康弘, 鎌田春彦, 角田慎一, 堤康央
- Organizer
  第59回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20890300
[Presentation] 創薬プロテオミクス研究を有効活用したバイオ創薬2009
- Author(s)
  阿部康弘, 角田慎一, 堤康央
- Organizer
  CphI Japan 2009
- Place of Presentation
  東京
- Year and Date
  2009-04-21
- Data Source
  KAKENHI-PROJECT-20890300
[Presentation] Creation and X-ray structural analysis of TNFR1-selective mutant TNF with antagonistic activity2009
- Author(s)
  Abe Y., Nomura T., Kayamuro H., Yoshioka Y., Kamada H., Tsunoda S., Tsutsumi Y
- Organizer
  HUPO 8th Annual World Congress, Toronto 2009
- Place of Presentation
  Tronto (Canada)
- Data Source
  KAKENHI-PROJECT-20890300
[Presentation] アンタゴニスト活性を有したTNFR1指向性変異体の新規自己免疫疾患治療薬としての有用性評価2008
- Author(s)
  阿部康弘, 野村鉄也, 柴田寛子, 吉岡靖雄, 中川晋作, 鎌田春彦, 角田慎一, 堤康央
- Organizer
  第58回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20890300
[Presentation] Fine tuning of receptor-selectivity for tumor necrosis factor-□ using a phage display system with one-step competitive-subtractive panning2008
- Author(s)
  Abe Y., Shibata H., Nomura T., Kayamuro H., Mukai Y., Yoshikawa T., Yoshioka Y., Taniai M., Ohta T., Nakagawa S., Kamada H., Tsunoda S., Tsutsumi Y
- Organizer
  7th Joint Conference of the Intenational Society for Interderon and Cytokine Research and International Cytokine Society
- Place of Presentation
  Montreal/Quebec (CANADA)
- Data Source
  KAKENHI-PROJECT-20890300
[Presentation] Fine tuning of receptor-selectivity for tumor necrosis factor-α using a phage display system with one-step competitive-subtractive panning2008
- Author(s)
  Abe Y., Shibata H., Nomura T., Kayamuro H., Mukai Y., Yoshikawa T., Yoshioka Y., Taniai M., Ohta T., Nakagawa S., Kamada H., Tsunoda S., Tsutsumi Y.
- Organizer
  7th Joint Conference of the Intenational Society for Interderon and Cytokine Research and International Cytokine Society
- Place of Presentation
  Montreal/Quebec (CANADA)
- Data Source
  KAKENHI-PROJECT-20890300

1. 角田慎一

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. 鎌田春彦

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 井上雅己

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 山根美紀

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 長野一也

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 野村鉄也

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 萱室裕之

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 河原倫之

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 有田修平

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 古屋剛

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Abe Yasuhiro 阿部 康弘

ABE Yasuhiro 阿部 康弘

Research Projects

Research Products

Co-Researchers

Development of Immunomodulatory Cytokine mutantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of functional mutant protein with antagonistic activity as an anti-inflammatory drugPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Development of a novel antibody proteomics system using a phage antibody library for efficient screening of tumor-related biomarker proteins.2011

Author(s)

Journal Title

Data Source

[Journal Article] Development of a novel antibody proteomics system using a phage antibody library for efficient screening of tumor-related biomarker proteins2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fine tuning of receptor-selectivity for tumor necrosis factor-a using a phage display system with one-step competitive panning2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Creation of TNFR1-selective antagonist and its therapeutic effects.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article]2010

Author(s)

Journal Title

Data Source

[Journal Article] The IL-1 family cytokines as mucosal vaccine adjuvant for the induction of protective immunity against influenza virus.2010

Author(s)

Journal Title

Data Source

[Journal Article] The IL-1 family cytokines as mucosal vaccine adjuvant for the induction of protective immunity against influenza virus2010

Author(s)

Journal Title

DOI

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[Journal Article] Creation of an improved mutant TNF with TNFR1-selectivity and antagonisitic activity by phage display technology.2010

Author(s)

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[Journal Article] Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology2010

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[Journal Article] Novel protein engineering strategy for creating highly receptor-selective mutant TNFs2009

Author(s)

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[Journal Article] Novel protein engineering strategy for creating highly receptor-selecive mutant TNFs.2009

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[Journal Article] Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant2009

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[Journal Article] Development of novel DDS technologies for optimized protein therapy by creating functional mutant proteins with antagonistic activity2009

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NAID

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[Journal Article] The specific effect of 2-Methoxyestradiol on lymphatic vascular endothelial cells2009

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[Journal Article] The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF.2009

Author(s)

Abe Yasuhiro 阿部康弘

ABE Yasuhiro 阿部康弘