Kono Masamitsu 河野正充

… Alternative Names

KONO Masamitsu 河野正充

河野正充コウノマサミツ

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Researcher Number	20511570
Affiliation (Current)	2025: 和歌山県立医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 和歌山県立医科大学, 医学部, 准教授 2020 – 2022: 和歌山県立医科大学, 医学部, 講師 2017 – 2019: 和歌山県立医科大学, 医学部, 助教 2017: 和歌山県立医科大学, 医学部, その他 2015: 和歌山県立医科大学, 医学部, 助教 2012 – 2013: 和歌山県立医科大学, 医学部, 助教 2011: Wakayama Medical University, 医学部, その他
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related / Basic Section 54030:Infectious disease medicine-related / Bacteriology (including mycology) Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 54030:Infectious disease medicine-related
Keywords	Principal Investigator 肺炎球菌 / ボトルネック効果 / Sonic hedgehog / 一過性受容体電位 / 嗅覚 / TRPチャネル / 嗅覚障害 / タイトジャンクション / タイト結合 / TLR … More / 侵襲性肺炎球菌感染症 / インフルエンザウィルス / 感染症 / 自然免疫 / 伝播 / Toll様受容体 / 宿主間伝播 / PspA / 母体免疫 … More Except Principal Investigator 肺炎球菌 / インフルエンザ菌 / 肺炎球菌ワクチン / 中耳炎 / TRP / 侵襲性肺炎球菌感染症 / 母体免疫 / ワクチン / 急性中耳炎 / pilus-1 / MUC16 / ムチン / 受動喫煙 / 無莢膜型 / 莢膜 / PspK / 無莢膜型肺炎球菌 / 腸内細菌叢 / 反復性中耳炎 / 口蓋扁桃摘出術 / 単一細胞解析 / 口腔常在菌叢 / 扁桃病巣疾患 / 侵襲性肺炎球菌感染 / インフルエンザ / 一過性受容体電位 / 肺炎球菌菌血症 / ノイラミニダーゼA / 鼻腔保菌 / 誤嚥性肺炎 / ノイラミニダーゼ / 免疫グロブリン / オプソニン化能 / 難治性中耳炎 / TRPチャンネルの関与 / 細菌感染症の成立と重症化 / pnuemolysin (PLN) / 肺炎球菌感染モデル / ニューモリシン / インフルエンザウイルス / TRP channel / 免疫学的記憶 / 母乳栄養 / 細菌 / ゲノム / 感染症 / 微生物 / red complex / 扁桃陰窩細菌叢 / 溶血性レンサ球菌 / マイクロビオーム / GAS / 細菌感染症 / microbiota / 扁桃周囲膿瘍 / 扁桃炎 / 菌叢解析 / tonsil / 16S / microbiome / PspA / メモリー / 血清型 Less

嗅上皮再生における一過性受容体電位TRPチャネル/Sonic Hedgehogの役割の解明Principal Investigator
- Principal Investigator
  
  河野正充
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Wakayama Medical University
受動喫煙による鼻腔におけるムチン産生の変化と肺炎球菌宿主間伝播への影響の解明
- Principal Investigator
  
  志賀達也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Wakayama Medical University
Roles of TRPV4 for developing invasive pneumococcal-viral co-infections
- Principal Investigator
  
  保富宗城
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Wakayama Medical University
Identification and Pathological Roles of a Single Parainfluenzae- Specific Lymphocyte in Tonsillar Focal Infection Desease
- Principal Investigator
  
  金子富美恵
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Wakayama Medical University
反復性中耳炎における肺炎球菌ワクチン不応答集団の同定と腸内細菌叢の役割解明
- Principal Investigator
  
  武田早織
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Wakayama Medical University
無莢膜型肺炎球菌の病原性解明と全菌体型肺炎球菌ワクチンによる予防効果の検証
- Principal Investigator
  
  酒谷英樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Wakayama Medical University
Investigation of polybacterial onset model of tonsillitis repetition and severity by crowd analysis of tonsil crypt microflora
- Principal Investigator
  
  Masanobu HIRAOKA
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Wakayama Medical University
Novel strategy against invasive pneumococcal diseases by regulating tight junction and bottleneck effectPrincipal Investigator
- Principal Investigator
  
  Kono Masamitsu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Wakayama Medical University
The role of transient receptor potential channels in developing invasive pneumococcal infection.
- Principal Investigator
  
  Sugita Gen
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Wakayama Medical University
The quantitative and qualitative evaluation of the specific antibody in otitis prone and the establishment of eligibility criteria for custom-made immunoglobulin therapy
- Principal Investigator
  
  Takeda Saori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Wakayama Medical University
Elucidation of the role of Streptococcus pneumoniae neuraminidase A in the development of new vaccines and prevention of aspiration pneumonia
- Principal Investigator
  
  Kaneko Fumie
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Wakayama Medical University
Single cell bottleneck in the pneumococcal transmission between host and hostPrincipal Investigator
- Principal Investigator
  
  Kono Masamitsu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Wakayama Medical University
Immunological reconstruction of neonate immunity by breast milk of maternal immunization
- Principal Investigator
  
  Muneki Hotomi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Wakayama Medical University
母体免疫由来の母乳栄養による新生児期免疫再構築に関する研究Principal Investigator
- Principal Investigator
  
  河野正充
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Wakayama Medical University
肺炎球菌ワクチン導入前後の肺炎球菌急性中耳炎分離株の血清型の変化に関する研究
- Principal Investigator
  
  山中昇
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Wakayama Medical University
Immunological memory induced by maternal intranasal immunization with PspA
- Principal Investigator
  
  Hotomi Muneki
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Wakayama Medical University
母体免疫におけるTh17/制御性T細胞サブセットの役割に関する研究Principal Investigator
- Principal Investigator
  
  河野正充
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Wakayama Medical University

All 2023 2022 2021 2020 2018 2017 2013

All Journal Article Presentation

[Journal Article] Investigation on the virulence of non-encapsulated Streptococcus pneumoniae using liquid agar pneumonia model.2022
- Author(s)
  Sakatani, H., Kono, M., Sugita, G., Nanushaj, D., Hijiya, M., Iyo, T., Shiga, T., Murakami, D., Kaku, N., Yanagihara, K., Nahm, M. H., & Hotomi, M.
- Journal Title
  
  Journal of infection and chemotherapy
  
  Volume: 28 Issue: 11 Pages: 1452-1458
- DOI
  10.1016/j.jiac.2022.07.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K10492
[Journal Article] The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease.2021
- Author(s)
  4.Kono M, Nanushaj D, Sakatani H, Murakami D, Hijiya M, Kinoshita T, Shiga T, Kaneko F, Enomoto K, Sugita G, Miyajima M, Okada Y, Saika S, Hotomi M
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 732029-732029
- DOI
  10.3389/fimmu.2021.732029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08959, KAKENHI-PROJECT-20K08825
[Journal Article] Pneumococcal capsular phase shift is associated with invasion into cell-to-cell junctions and is inhibited by macrolides.2021
- Author(s)
  Takeda S, Kono M, Sugita G, Arai J, Briles DE, Hotomi M.
- Journal Title
  
  Microb Pathog.
  
  Volume: 153 Pages: 104787-104787
- DOI
  10.1016/j.micpath.2021.104787
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08825
[Journal Article] Panel 5: Immunology2017
- Author(s)
  Kyd JM, Hotomi M, Kono M, Kurabi A, Pichichero M, Ryan A, Swords WE, Thornton R
- Journal Title
  
  Otolaryngol Head Neck Surg
  
  Volume: 156(4 suppl) Issue: S4
- DOI
  10.1177/0194599816663886
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10758
[Presentation] 鼻バリア機構による感染症の重症化制御2023
- Author(s)
  河野正充
- Organizer
  第3回日本耳鼻咽喉科免疫アレルギー感染症学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08825
[Presentation] 反復性中耳炎患児における抗肺炎球菌特異的抗体の量的・質的評価法の確立2023
- Author(s)
  河野正充
- Organizer
  第18回日本小児耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-22K09690
[Presentation] 肺炎球菌の pathogenesis と宿主免疫機構2022
- Author(s)
  河野正充
- Organizer
  第92回日本感染症学会西日本地方会学術集会・第65回日本感染症学会中日本地方会学術集会・第70回日本化学療法学会西日本支部総会合同学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08825
[Presentation] Spontaneous phase shift during the establishment of pneumococcal colonization2022
- Author(s)
  河野正充
- Organizer
  第95回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08825
[Presentation] 温痛覚受容体による鼻腔保菌から侵襲性肺炎球菌感染症への進展制御2022
- Author(s)
  河野正充、酒谷英樹、村上大地、大谷真喜子、保富宗城
- Organizer
  第2回日本耳鼻咽喉科免疫アレルギー感染症学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-19K08959
[Presentation] 肺炎球菌感染症における自然免疫の核酸認識機構の役割について2021
- Author(s)
  河野正充
- Organizer
  第１２２回日本耳鼻咽喉科学会総会
- Data Source
  KAKENHI-PROJECT-20K08825
[Presentation] 肺炎球菌の保菌・感染・伝播のメカニズム2021
- Author(s)
  河野正充
- Organizer
  第91回日本感染症学会西日本地方会学術集会・第64回日本感染症学会中日本地方会学術集会・第69回日本化学療法学会西日本支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08959
[Presentation] Roles of Nucleic Acid Sensing TLRs for Pneumococcal Invasion2021
- Author(s)
  Nanushaj Denisa, Masamitsu Kono, Hideki Sakatani, Daichi Murakami, Muneki Hotomi
- Organizer
  第91回日本感染症学会西日本地方会学術集会・第64回日本感染症学会中日本地方会学術集会・第69回日本化学療法学会西日本支部総会合同学会
- Data Source
  KAKENHI-PROJECT-20K08825
[Presentation] The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Invasive Disease2021
- Author(s)
  Masamitsu Kono, Denisa Nanushaj, Hideki Sakatani, Daichi Murakami, Gen Sugita, Muneki Hotomi
- Organizer
  The 3rd Asian Pneumococcal Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08825
[Presentation] 肺炎球菌感染症における自然免疫の核酸認識機構の役割について2021
- Author(s)
  河野正充、村上大地、酒谷英樹、金子富美恵、保富宗城
- Organizer
  第122回日本耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-20K08825
[Presentation] The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Invasive Disease2021
- Author(s)
  Masamitsu Kono, Denisa Nanushaj, Hideki Sakatani, Daichi Murakami, Gen Sugita, Muneki Hotomi
- Organizer
  The 3rd Asian Pneumococcal Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08959
[Presentation] 侵襲性肺炎球菌感染症発症過程における核酸認識Toll様受容体の役割について2021
- Author(s)
  河野正充
- Organizer
  第９５回日本感染症学会・第６９回日本化学療法学会合同学会
- Data Source
  KAKENHI-PROJECT-20K08825
[Presentation] 感染症研究の新たな展開：肺炎球菌の保菌と感染における感覚受容体の関与2021
- Author(s)
  河野正充
- Organizer
  第１回日本耳鼻咽喉科免疫アレルギー感染症学会総会・学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08959
[Presentation] 肺炎球菌の保菌・感染・伝播のメカニズム2021
- Author(s)
  河野正充
- Organizer
  第91回日本感染症学会西日本地方会学術集会・第64回日本感染症学会中日本地方会学術集会・第69回日本化学療法学会西日本支部総会合同学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08825
[Presentation] 感染症研究の新たな展開：肺炎球菌の保菌と感染における感覚受容体の関与2021
- Author(s)
  河野正充
- Organizer
  第１回日本耳鼻咽喉科免疫アレルギー感染症学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08825
[Presentation] 侵襲性肺炎球菌感染症発症過程におけるエンドソーム局在Toll様受容体の役割について2021
- Author(s)
  河野正充、村上大地、酒谷英樹、金子富美恵、保富宗城
- Organizer
  第95回日本感染症学会学術講演会・第69回日本化学療法学会総会
- Data Source
  KAKENHI-PROJECT-20K08825
[Presentation] マウス鼻腔での肺炎球菌定着におけるneuraminidase Aの影響2020
- Author(s)
  金子富美恵, 河野正充, 須納瀬弘, 保富宗城
- Organizer
  第8回日本耳鼻咽喉科感染症・エアロゾル学会
- Data Source
  KAKENHI-PROJECT-19K09878
[Presentation] The Role of TRP in Pathogenesis of Streptococcus pneumoniae2020
- Author(s)
  Denisa Nanushaj, Muneki Hotomi, Masamitsu Kono
- Organizer
  International Symposium on TRP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08959
[Presentation] インフルエンザウィルス重感染による肺炎球菌の宿主間伝播促進における宿主自然免疫の役割について2018
- Author(s)
  河野正充
- Organizer
  第66回日本化学療法学会西日本支部総会
- Data Source
  KAKENHI-PROJECT-17K15690
[Presentation] インフルエンザウィルス重感染による肺炎球菌の宿主間伝播促進における宿主の局所炎症反応の役割について2017
- Author(s)
  河野正充
- Organizer
  第5回日本耳鼻咽喉科感染症・エアロゾル学会
- Data Source
  KAKENHI-PROJECT-17K15690
[Presentation] インフルエンザウィルス重感染による肺炎球菌の宿主間伝播促進における宿主自然免疫の役割について2017
- Author(s)
  河野正充
- Organizer
  第65回日本化学療法学会西日本支部総会
- Data Source
  KAKENHI-PROJECT-17K15690
[Presentation] Memory of PspA specific immune responses in offspring delivered from immunized mother mice.2013
- Author(s)
  河野正充
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25861584

1. Hotomi Muneki (90336892)

# of Collaborated Projects: 9 results

# of Collaborated Products: 7 results
2. SUGITA Gen (20407274)

# of Collaborated Projects: 7 results

# of Collaborated Products: 4 results
3. HIROKA Masanobu (80423945)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. 村上大地 (30794218)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
5. Takeda Saori (20644090)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. Kaneko Fumie (40328414)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 酒谷英樹 (30817317)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
8. IKEDA Yorihiko (20423949)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. YUASA Jun (10725550)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. Togawa Akihisa (70305762)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 田村真司 (10244724)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 大谷真喜子 (00795594)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
13. 伊豫巧朗 (70895820)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
14. 山中昇 (10136963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 玉川俊次 (40543781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 須納瀬弘 (50261631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 雑賀司珠也 (40254544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 高原幹 (50322904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 藤代拓 (40934807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 桑添博紀 (80929141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 志賀達也 (80890863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 平石富美恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kono Masamitsu 河野 正充

KONO Masamitsu 河野 正充

河野 正充 コウノ マサミツ

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Co-Researchers

嗅上皮再生における一過性受容体電位TRPチャネル/Sonic Hedgehogの役割の解明Principal Investigator

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Novel strategy against invasive pneumococcal diseases by regulating tight junction and bottleneck effectPrincipal Investigator

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Single cell bottleneck in the pneumococcal transmission between host and hostPrincipal Investigator

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母体免疫由来の母乳栄養による新生児期免疫再構築に関する研究Principal Investigator

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Kono Masamitsu 河野正充

KONO Masamitsu 河野正充

河野正充コウノマサミツ