OIKAWA TSUNEKAZU 及川恒一

… Alternative Names

Oikawa Tsunekazu 及川恒一

OIKAWA Tsunekazu 及川恒一

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Researcher Number	20514491
Other IDs
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 東京慈恵会医科大学, 医学部, 准教授 2023: 東京慈恵会医科大学, 医学部, 准教授 2018 – 2022: 東京慈恵会医科大学, 医学部, 講師 2015 – 2017: 東京慈恵会医科大学, 医学部, 助教 2008 – 2011: Jikei University School of Medicine, 医学部, 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 肝癌 / 癌幹細胞 / 転移 / がん幹細胞 / 分化 / 幹細胞 / がん免疫微小環境 / 複合免疫療法 / 型破り分泌蛋白質 / バイオマーカー … More / 型破り分泌蛋白 / 早期診断 / 肝発生 / 肝幹細胞 / 腫瘍形成 / 転写因子 / 再生医療 Less

DYRKファミリーによる肝がん免疫微小環境改変と将来的な治療応用への検証研究Principal Investigator
- Principal Investigator
  
  及川恒一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Jikei University School of Medicine
肝癌特異的な細胞外分泌蛋白を用いた新規早期診断法確立とその実用化に向けた検証研究Principal Investigator
- Principal Investigator
  
  及川恒一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Jikei University School of Medicine
Gene therapy development in liver cancerPrincipal Investigator
- Principal Investigator
  
  Oikawa Tsunekazu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Jikei University School of Medicine
The role of DYRK2 in primary liver cancersPrincipal Investigator
- Principal Investigator
  
  Oikawa Tsunekazu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jikei University School of Medicine
肝癌の起源と癌幹細胞の制御機構及び新規治療法の解明Principal Investigator
- Principal Investigator
  
  及川恒一
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  Jikei University School of Medicine
肝癌幹細胞における発癌、進展制御メカニズムの解明Principal Investigator
- Principal Investigator
  
  及川恒一
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Jikei University School of Medicine
Analyses of cell fate determination in fetal hepatoblastPrincipal Investigator
- Principal Investigator
  
  OIKAWA Tsunekazu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Gastroenterology
- Research Institution
  Jikei University School of Medicine

All 2024 2023 2022 2020 2019 2018 2017 2016 2015 2011 2010 2009 2008

All Journal Article Presentation Book

[Book] ジンクフィンガー蛋白質Sall4による肝幹・前駆細胞分化決定の制御機構2009
- Author(s)
  及川恒一,紙谷聡英,中内啓光
- Publisher
  分子消化器病学
- Data Source
  KAKENHI-PROJECT-20890229
[Book] 分子消化器病学2009
- Author(s)
  及川恒一、紙谷聡英、中内啓光
- Total Pages
  4
- Publisher
  ジンクフィンガータンパク質Sall4によるマウス肝幹・前駆細胞分化決定の制御機構
- Data Source
  KAKENHI-PROJECT-20890229
[Journal Article] Protein kinase C delta enhances the diagnostic performance of hepatocellular carcinoma.2024
- Author(s)
  Nakagawa C, Oikawa T , Yamada K, Tsubota A, Saeki C, Katagiri K, Tago N, Kamioka H, Ueda K, Haruki K, Furukawa K, Nakano M, Torisu Y, Ikegami T, Yoshida K, Saruta M
- Journal Title
  
  Biomarkers
  
  Volume: 29 Issue: 2 Pages: 55-67
- DOI
  10.1080/1354750x.2024.2312990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08063, KAKENHI-PROJECT-22K08587, KAKENHI-PROJECT-21K08718
[Journal Article] Protein Kinase C Delta Is a Novel Biomarker for Hepatocellular Carcinoma.2023
- Author(s)
  Oikawa T, Yamada K, Tsubota A, Saeki C, Tago N, Nakagawa C, Ueda K, Kamioka H, Taniai T, Haruki K, Nakano M, Torisu Y, Ikegami T, Yoshida K, and Saruta M.
- Journal Title
  
  Gastro Hep Advances
  
  Volume: 2 Issue: 1 Pages: 83-95
- DOI
  10.1016/j.gastha.2022.07.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08063, KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-20K07621
[Journal Article] Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B<sup>+</sup>vesicle pathway in liver cancer2022
- Author(s)
  Yamada Kohji、Motohashi Saya、Oikawa Tsunekazu、Tago Naoko、Koizumi Rei、Ono Masaya、Tachibana Toshiaki、Yoshida Ayano、Yoshida Saishu、Shimoda Masayuki、Oka Masahiro、Yoneda Yoshihiro、Yoshida Kiyotsugu
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 36
- DOI
  10.1073/pnas.2202730119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06192, KAKENHI-PROJECT-22K08063, KAKENHI-PROJECT-20H03444, KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-20K07621, KAKENHI-PROJECT-23K24116
[Journal Article] Unconventional Secretion of PKCδ Exerts Tumorigenic Function via Stimulation of ERK1/2 Signaling in Liver Cancer2020
- Author(s)
  Yamada Kohji、Oikawa Tsunekazu、Kizawa Ryusuke、Motohashi Saya、Yoshida Saishu、Kumamoto Tomotaka、Saeki Chisato、Nakagawa Chika、Shimoyama Yuya、Aoki Katsuhiko、Tachibana Toshiaki、Saruta Masayuki、Ono Masaya、Yoshida Kiyotsugu
- Journal Title
  
  Cancer Research
  
  Volume: 81 Issue: 2 Pages: 414-425
- DOI
  10.1158/0008-5472.can-20-2009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07621, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-18K15253, KAKENHI-PROJECT-19K16781, KAKENHI-PROJECT-19K08429
[Journal Article] Forced expression of DYRK2 exerts anti-tumor effects via apoptotic induction in liver cancer.2019
- Author(s)
  Yokoyama-Mashima S, Yogosawa S, Kanegae Y, Hirooka S, Yoshida S, Horiuchi T, Ohashi T, Yanaga K, Saruta M, Oikawa T, Yoshida K.
- Journal Title
  
  Cancer Lett
  
  Volume: 451 Pages: 100-109
- DOI
  10.1016/j.canlet.2019.02.046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09378, KAKENHI-PROJECT-16K18818, KAKENHI-PROJECT-19K08429, KAKENHI-PROJECT-17H03584
[Journal Article] Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma.2017
- Author(s)
  Dinh TA, Vitucci EC, Wauthier E, Graham RP, Pitman WA, Oikawa T, Chen M, Silva GO, Greene KG, Torbenson MS, Reid LM, Sethupathy P.
- Journal Title
  
  Sci Rep.
  
  Volume: 17 Issue: 1 Pages: 44653-44653
- DOI
  10.1038/srep44653
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09378
[Journal Article] Cancer stem cells and their origin of primary liver and biliary tract cancers.2016
- Author(s)
  Oikawa T
- Journal Title
  
  Hepatology
  
  Volume: in press Issue: 2 Pages: 645-651
- DOI
  10.1002/hep.28485
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H06633, KAKENHI-PROJECT-16K09378
[Journal Article] Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells.2015
- Author(s)
  Oikawa T, Wauthier E, Dinh TA, Selitsky SR, Reyna-Neyra A, Carpino G, Levine R, Cardinale V, Klimstra D, Gaudio E, Alvaro D, Carrasco N, Sethupathy P, Reid LM
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 8070-8070
- DOI
  10.1038/ncomms9070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06633
[Journal Article] Sall4 Regulates Cell Fate Decision in Fetal Hepatic Stem/Progenitor Cells.2009
- Author(s)
  Tsunekazu Oikawa, Akihide Kamiya, Sei Kakinuma, Mikio Zeniya, Ryuichi Nishinakamura, Hisao Tajiri, Hiromitsu Nakauchi
- Journal Title
  
  Gastroenterology 136
  
  Pages: 1000-1011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890229
[Journal Article] Sall4 Regulates Cell Fate Decision in Fetal Hepatic Stem/Progenitor Cells.2009
- Author(s)
  Tsunekazu Oikawa
- Journal Title
  
  Gastroenterology 136
  
  Pages: 1000-1011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890229
[Presentation] 早期診断に有用な肝細胞癌特異的バイオマーカー血清PKCδ2023
- Author(s)
  及川恒一, 神岡洋, 猿田雅之
- Organizer
  第30回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-22K08063
[Presentation] 血清PKCδは既存マーカーを補完し、かつ早期発見に有用な肝細胞癌特異的バイオマーカーである2023
- Author(s)
  及川恒一, 猿田雅之, 坪田昭人
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K08063
[Presentation] 新規肝細胞癌バイオマーカーとしての血清PKCδの有用性2022
- Author(s)
  及川恒一, 猿田雅之, 坪田昭人
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K08063
[Presentation] 肝癌におけるDYRK2の関与2018
- Author(s)
  間嶋志保、及川恒一、與五沢里美、吉田清嗣、猿田雅之
- Organizer
  第25回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-16K09378
[Presentation] 癌幹細胞の特徴を持ち合わせた世界初ヒトFL-HCC patient-derived xenograft tumor model2016
- Author(s)
  及川恒一, Lola Reid
- Organizer
  第52回肝臓学会総会
- Place of Presentation
  ホテルニューオータニ幕張
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K09378
[Presentation] Fibrolamellar Hepatocellular Carcinoma 患者由来異種移植片モデルの確立2016
- Author(s)
  及川恒一, Praveen Sethupathy, Lola Reid
- Organizer
  第102回消化器病学会総会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2016-04-22
- Data Source
  KAKENHI-PROJECT-16K09378
[Presentation] 世界初FL-HCC patient-derived xenograft tumor modelを用いた新規治療法の開発戦略2016
- Author(s)
  及川恒一、Eliane Wauthier, Timothy Dinh, Praveen Sethupathy, Lola Reid, 猿田雅之
- Organizer
  第23回肝細胞研究会
- Place of Presentation
  大阪大学中之島センター
- Year and Date
  2016-07-08
- Data Source
  KAKENHI-PROJECT-16K09378
[Presentation] ヒト肝癌細胞株におけるSALL4の関与2011
- Author(s)
  及川恒一、紙谷聡英、西野博一、銭谷幹男、中内啓光、田尻久雄
- Organizer
  第18回肝細胞研究会
- Place of Presentation
  東京・東京ガーデンパレス
- Year and Date
  2011-06-25
- Data Source
  KAKENHI-PROJECT-22790674
[Presentation] ジンクフィンガータンパク質SALL4の肝癌細胞株における機能解析2010
- Author(s)
  及川恒一、紙谷聡英、銭谷幹男、中内啓光、田尻久雄
- Organizer
  第17回肝細胞研究会
- Place of Presentation
  秋田・秋田アトリオン
- Year and Date
  2010-06-19
- Data Source
  KAKENHI-PROJECT-22790674
[Presentation] 肝癌細胞株におけるジンクフィンガータンパク質SALL4の機能解析2010
- Author(s)
  及川恒一、紙谷聡英、銭谷幹男、中内啓光、田尻久雄
- Organizer
  第18回日本消化器関連学会週間
- Place of Presentation
  横浜・国際会議場
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-22790674
[Presentation] Down-Regulation of SALL4 inhibits Tumor Growth in Hepatocellular Carcinoma2010
- Author(s)
  Tsunekazu Oikawa, Akihide Kamiya, Mikio Zeniya, Hirokazu Nishino, Hiromitsu Nakauchi, Hisao Tajiri.
- Organizer
  FASEB Summer Research Conference
- Place of Presentation
  Snowmass Village, CO, U.S.A
- Year and Date
  2010-08-19
- Data Source
  KAKENHI-PROJECT-22790674
[Presentation] Down-Regulation of SALL4 inhibits Tumor Growth in Hepatocellular Carcinoma2010
- Author(s)
  Tsunekazu Oikawa, Akihide Kamiya, Mikio Zeniya, Hirokazu Nishino, Hiromitsu Nakauchi, Hisao Tajiri
- Organizer
  The 61th Annual Meeting of the American Association for Study of the Liver Diseases
- Place of Presentation
  Hynes Convention Center, Boston, MA, U.S.A
- Year and Date
  2010-11-01
- Data Source
  KAKENHI-PROJECT-22790674
[Presentation] Involvement of SALL4 in Tumor Growth of Hepatocellular Carcinoma Cells2010
- Author(s)
  Tsunekazu Oikawa, Akihide Kamiya, Mikio Zeniya, Hirokazu Nishino, Hiromitsu Nakauchi, Hisao Tajiri.
- Organizer
  The 1st JSGE International Topic Conference
- Place of Presentation
  Kamakura Park Hotel, Japan
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-22790674
[Presentation] マウス肝幹前駆細胞の胆管細胞分化過程におけるジンクフィンガータンパク質Sall4による制御機構2009
- Author(s)
  及川恒一
- Organizer
  第17回日本消化器関連学会週間(JDDW 2009)
- Place of Presentation
  京都国際会議場
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-20890229
[Presentation] 胎児由来肝幹・前駆細胞の胆管細胞分化過程におけるジンクフィンガータンパク質Sall4の関与2009
- Author(s)
  及川恒一
- Organizer
  第16回肝細胞研究会
- Place of Presentation
  山形山形テルサ
- Year and Date
  2009-06-27
- Data Source
  KAKENHI-PROJECT-20890229
[Presentation] 胎児由来肝幹・前駆細胞の胆管細胞分化過程におけるジンクフィンガータンパク質Sall4の関与2009
- Author(s)
  及川恒一, 紙谷聡英, 柿沼晴, 銭谷幹男, 西中村隆一, 中内啓光, 田尻久雄
- Organizer
  第16回肝細胞研究会山形テルサ
- Data Source
  KAKENHI-PROJECT-20890229
[Presentation] マウス肝幹前駆細胞の胆管細胞分化過程におけるジンクフィンガータンパク質Sall4による制御機構2009
- Author(s)
  及川恒一, 田尻久雄, 中内啓光
- Organizer
  第17回日本消化器関連学会週間
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-20890229
[Presentation] ジンクフィンガータンパク質Sall4によるマウス肝幹・前駆細胞の肝/胆管細胞への分化制御機構2008
- Author(s)
  及川恒一
- Organizer
  日本消化器関連学会週間(JDDW2008)
- Place of Presentation
  東京(グランドプリンスホテル新高輪)
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-20890229
[Presentation] ジンクフィンガータンパク質Sall4によるマウス肝幹・前駆細胞の肝/胆管細胞への分化制御機構2008
- Author(s)
  及川恒一, 銭谷幹男, 中内啓光
- Organizer
  第16回日本消化器関連学会週間
- Place of Presentation
  東京グランドプリンスホテル新高輪
- Data Source
  KAKENHI-PROJECT-20890229
[Presentation] Sall4 regulates cell fate decision in fetal hepatoblasts.2008
- Author(s)
  Tsunekazu Oikawa
- Organizer
  The 59th Annual Meeting of the American Association for Study of the Liver Diseases.
- Place of Presentation
  Moscone West Convention Center, San Francisco, CA, U.S.A
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-20890229
[Presentation] Sall4 Regulates Cell Fate Decision in Fetal Hepatoblasts.2008
- Author(s)
  Tsunekazu Oikawa, Akihide Kamiya, Sei Kakinuma, Mikio Zeniya, Ryuichi Nishinakamura, Hiromitsu Nakauchi, Hisao Tajiri
- Organizer
  The 59th Annual Meeting of the American Association for Study of the Liver Diseases, Moscone West Convention Center
- Place of Presentation
  San Francisco, CA, U.S.A
- Data Source
  KAKENHI-PROJECT-20890229

1. 吉田清嗣 (70345312)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. 坪田昭人 (90322643)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. Mashima Shiho

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. Yogosawa Satomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 立花利公

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 山田幸司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 吉田彩舟

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

OIKAWA TSUNEKAZU 及川 恒一

Oikawa Tsunekazu 及川 恒一

OIKAWA Tsunekazu 及川 恒一

Research Projects

Research Products

Co-Researchers

DYRKファミリーによる肝がん免疫微小環境改変と将来的な治療応用への検証研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肝癌特異的な細胞外分泌蛋白を用いた新規早期診断法確立とその実用化に向けた検証研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Gene therapy development in liver cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of DYRK2 in primary liver cancersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肝癌の起源と癌幹細胞の制御機構及び新規治療法の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肝癌幹細胞における発癌、進展制御メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of cell fate determination in fetal hepatoblastPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ジンクフィンガー蛋白質Sall4による肝幹・前駆細胞分化決定の制御機構2009

Author(s)

Publisher

Data Source

[Book] 分子消化器病学2009

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Protein kinase C delta enhances the diagnostic performance of hepatocellular carcinoma.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protein Kinase C Delta Is a Novel Biomarker for Hepatocellular Carcinoma.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B<sup>+</sup>vesicle pathway in liver cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unconventional Secretion of PKCδ Exerts Tumorigenic Function via Stimulation of ERK1/2 Signaling in Liver Cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Forced expression of DYRK2 exerts anti-tumor effects via apoptotic induction in liver cancer.2019

Author(s)

Journal Title

OIKAWA TSUNEKAZU 及川恒一

Oikawa Tsunekazu 及川恒一

OIKAWA Tsunekazu 及川恒一