SHODA HIROFUMI 庄田宏文

… Alternative Names

SHODA Hirofumi 庄田宏文

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Researcher Number	20529036
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 東京大学, 医学部附属病院, 准教授 2017 – 2020: 東京大学, 医学部附属病院, 講師 2011 – 2016: 東京大学, 医学部附属病院, 助教 2010: 東京大学, 医学部・附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology / 膠原病・アレルギー・感染症内科学 Except Principal Investigator 膠原病・アレルギー・感染症内科学 / Broad Section I
Keywords	Principal Investigator 樹状細胞 / インターフェロン / iPS細胞 / 全身性エリテマトーデス / 関節リウマチ / 創薬 / rare variant / 制御性T細胞 / T細胞受容体 / BiP … More / T細胞 / フラグメント分子軌道法 / 疾患感受性遺伝子変異 / 膠原病 / 好中球 / PADI4 / 遺伝子変異 / 抗酸菌 / 自己抗原 / エピトープ / ペプチド療法 / HLA-DRエピトープ / ペプチド療 / Bip / CD4陽性T細胞 / Interleukin / HLA-DRB1 / HLA-DRB1多型 / 新規治療法 … More Except Principal Investigator ゲノム / エピゲノム解析 / オミックス / ホールトランスクリプトーム解析 / 一塩基多型 / 多因子性疾患 / クロマチンステイタス解析 / クロマチン構造解析 / eQTL解析 / マルチオミクス解析 / 遺伝子多型 / シングルセル解析 / オープンクロマチン解析 / エンハンサー / プロモーター / 遺伝子発現量 / エピゲノム / プロモーターエンハンサー解析 / 遺伝子発現量解析 / 疾患関連遺伝子多型 / 免疫細胞分画 / QTL解析 / 量的形質遺伝子座 / 疾患感受性遺伝子変異 / ゲノムワイド関連解析 / ヒト免疫 / 免疫疾患 / 多因子疾患 / PADI4 / Bip / シトルリン / T細胞 / 関節リウマチ / 細胞・組織 / 生体分子 / 組織・細胞 / 免疫学 / 内科 Less

iPS細胞を活用した自己免疫疾患病態研究推進のためのスキーム策定Principal Investigator
- Principal Investigator
  
  庄田宏文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  The University of Tokyo
Establishment of iPS cell-based strategy for elucidating the pathogenesis of autoimmune diseases and discovery of therapeutic targetsPrincipal Investigator
- Principal Investigator
  
  Shoda Hirofumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  The University of Tokyo
Establishment of a novel strategy for pathological analysis of multifactorial diseases using genetic risk variants
- Principal Investigator
  
  Yamamoto Kazuhiko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  Institute of Physical and Chemical Research
Investigation of novel therapeutic targets in dendritic cells for systemic lupus erythematosusPrincipal Investigator
- Principal Investigator
  
  SHODA HIROFUMI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  The University of Tokyo
Antigen specific therapy for rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  Shoda Hirofumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  The University of Tokyo
Generation of novel therapeutic strategies for rheumatoid arthritis by reguIation of autoantigen-specific T cellsPrincipal Investigator
- Principal Investigator
  
  SHODA Hirofumi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
Development of rheumatoid arthritis-directed human immunology
- Principal Investigator
  
  YAMAMOTO KAZUHIKO
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
関節リウマチにおける自己抗原とそれに対する免疫応答制御
- Principal Investigator
  
  山本一彦
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
Development of antigen specific therapy for rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  SHODA Hirofumi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo

All 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012 2011 2010 Other

All Journal Article Presentation Patent Other

[Journal Article] Dysregulation of the gene signature of effector regulatory T cells in the early phase of systemic sclerosis2022
- Author(s)
  Kobayashi Satomi、Nagafuchi Yasuo、Okubo Mai、Sugimori Yusuke、Hatano Hiroaki、Yamada Saeko、Nakano Masahiro、Yoshida Ryochi、Takeshima Yusuke、Ota Mineto、Tsuchida Yumi、Iwasaki Yukiko、Setoguchi Keigo、Kubo Kanae、Okamura Tomohisa、Yamamoto Kazuhiko、Shoda Hirofumi、Fujio Keishi
- Journal Title
  
  Rheumatology
  
  Volume: Online ahead of print Issue: 10 Pages: 4163-4174
- DOI
  10.1093/rheumatology/keac031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-21K16283, KAKENHI-PROJECT-20K08800
[Journal Article] Control of naive and effector CD4 T cell receptor repertoires by rheumatoid-arthritis-risk HLA alleles2022
- Author(s)
  Nagafuchi Yasuo、Ota Mineto、Hatano Hiroaki、Inoue Mariko、Kobayashi Satomi、Okubo Mai、Sugimori Yusuke、Nakano Masahiro、Yamada Saeko、Yoshida Ryochi、Tsuchida Yumi、Iwasaki Yukiko、Shoda Hirofumi、Okada Yukinori、Yamamoto Kazuhiko、Ishigaki Kazuyoshi、Okamura Tomohisa、Fujio Keishi
- Journal Title
  
  Journal of Autoimmunity
  
  Volume: 133 Pages: 102907-102907
- DOI
  10.1016/j.jaut.2022.102907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16283, KAKENHI-PROJECT-20K08800, KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K24369, KAKENHI-PROJECT-23K24373
[Journal Article] Distinct transcriptome architectures underlying lupus establishment and exacerbation2022
- Author(s)
  Nakano Masahiro　et al.
- Journal Title
  
  Cell
  
  Volume: 185 Issue: 18 Pages: 3375-3389.e21
- DOI
  10.1016/j.cell.2022.07.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-20K08800, KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K24373
[Journal Article] Serum extracellular traps associate with the activation of myeloid cells in SLE patients with the low level of anti-DNA antibodies2022
- Author(s)
  Hanata Norio、Ota Mineto、Tsuchida Yumi、Nagafuchi Yasuo、Okamura Tomohisa、Shoda Hirofumi、Fujio Keishi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1
- DOI
  10.1038/s41598-022-23076-1
- Data Source
  KAKENHI-PROJECT-20K08800
[Journal Article] Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci2022
- Author(s)
  Yamaguchi Kensuke、Ishigaki Kazuyoshi、Suzuki Akari、Tsuchida Yumi、Tsuchiya Haruka、Sumitomo Shuji、Nagafuchi Yasuo、Miya Fuyuki、Tsunoda Tatsuhiko、Shoda Hirofumi、Fujio Keishi、Yamamoto Kazuhiko、Kochi Yuta
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 4659-4659
- DOI
  10.1038/s41467-022-32358-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-20K08800, KAKENHI-PROJECT-21K19501, KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K23860, KAKENHI-PROJECT-23K24373
[Journal Article] Autotaxin is a potential link between genetic risk factors and immunological disturbances of plasmacytoid dendritic cells in systematic lupus erythematosus2022
- Author(s)
  Tsuchida Yumi、Shoda Hirofumi、Nakano Masahiro、Ota Mineto、Okamura Tomohisa、Yamamoto Kazuhiko、Kurano Makoto、Yatomi Yutaka、Fujio Keishi、Sawada Tetsuji
- Journal Title
  
  Lupus
  
  Volume: 31 Issue: 13 Pages: 1578-1585
- DOI
  10.1177/09612033221128494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-20K08800
[Journal Article] Serum Amphiregulin and Heparin-Binding Epidermal Growth Factor as Biomarkers in Patients with Idiopathic Inflammatory Myopathy2021
- Author(s)
  Hanata Norio、Nagafuchi Yasuo、Sugimori Yusuke、Kobayashi Satomi、Tsuchida Yumi、Iwasaki Yukiko、Shoda Hirofumi、Fujio Keishi
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 10 Issue: 16 Pages: 3730-3730
- DOI
  10.3390/jcm10163730
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17439, KAKENHI-PROJECT-20K08800
[Journal Article] Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases2021
- Author(s)
  Ota M, Nagafuchi Y, Hatano H, Ishigaki K, Terao C, Takeshima Y, Yanaoka H, Kobayashi S, Okubo M, Shirai H, Sugimori Y, Maeda J, Nakano M, Yamada S, Yoshida R, Tsuchiya H, Tsuchida Y, Iwasaki Y, Sumitomo S, Shoda H, Kochi Y, Okada Y, Yamamoto K, Okamura T, Fujio K, et al.
- Journal Title
  
  Cell
  
  Volume: 184 Issue: 11 Pages: 1-16
- DOI
  10.1016/j.cell.2021.03.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08771, KAKENHI-PROJECT-18H02849, KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-21K16283, KAKENHI-PROJECT-20K08800
[Journal Article] Identifying the most influential gene expression profile in distinguishing ANCA-associated vasculitis from healthy controls.2021
- Author(s)
  Yanaoka H, Nagafuchi Y, Hanata N, Takeshima Y, Ota M, Suwa Y, Shirai H, Sugimori Y, Okubo M, Kobayashi S, Hatano H, Yamada S, Tsuchida Y, Iwasaki Y, Sumitomo S, Shoda H, Okada M, Okamura T, Yamamoto K, Fujio K.
- Journal Title
  
  J Autoimmun.
  
  Volume: 119 Pages: 102617-102617
- DOI
  10.1016/j.jaut.2021.102617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17439, KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-20K08800
[Journal Article] Integrated bulk and single-cell RNA-sequencing identified disease-relevant monocytes and a gene network module underlying systemic sclerosis.2021
- Author(s)
  Kobayashi S, Nagafuchi Y, Okubo M, Sugimori Y, Shirai H, Hatano H, Junko M, Yanaoka H, Takeshima Y, Ota M, Iwasaki Y, Sumitomo S, Okamura T, Yamamoto K, Shoda H, Fujio K.
- Journal Title
  
  J Autoimmun
  
  Volume: 116 Pages: 102547-102547
- DOI
  10.1016/j.jaut.2020.102547
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-20K08800
[Journal Article] Decreased peripheral blood memory B cells are associated with the presence of interstitial lung disease in rheumatoid arthritis: a case-control study.2021
- Author(s)
  Shimizu T, Nagafuchi Y, Harada H, Tsuchida Y, Tsuchiya H, Hanata N, Tateishi S, Kanda H, Sumitomo S, Shoda H, Yamamoto K, Fujio K.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 31 Issue: 1 Pages: 127-132
- DOI
  10.1080/14397595.2020.1719596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17439, KAKENHI-PROJECT-20K08800
[Journal Article] Peptidylarginine Deiminase 4 Promotes the Renal Infiltration of Neutrophils and Exacerbates the TLR7 Agonist-Induced Lupus Mice2020
- Author(s)
  Norio Hanata, Hirofumi Shoda, Hiroaki Hatano, Yasuo Nagafuchi, Toshihiko Komai, Tomohisa Okamura, Akari Suzuki, I Ketut Gunarta, Katsuji Yoshioka, Kazuhiko Yamamoto, Keishi Fujio
- Journal Title
  
  Frontiers in immunology
  
  Volume: 11 Pages: 1095-1095
- DOI
  10.3389/fimmu.2020.01095
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16737, KAKENHI-PROJECT-20K17439, KAKENHI-PROJECT-20K08800
[Journal Article] Elevation of cytomegalovirus antigenemia predicts serious infection and death in patients receiving immunosuppressive therapies for autoimmune diseases.2020
- Author(s)
  Yoshihara R, Komai T, Shoda H, Fujio K.
- Journal Title
  
  Int J Rheum Dis.
  
  Volume: 23 Issue: 11 Pages: 1534-1540
- DOI
  10.1111/1756-185x.13990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08800
[Journal Article] Immune Profiling and Precision Medicine in Systemic Lupus Erythematosus2019
- Author(s)
  Nagafuchi Yasuo、Shoda Hirofumi、Fujio Keishi
- Journal Title
  
  Cells
  
  Volume: 8 Issue: 2 Pages: 140-140
- DOI
  10.3390/cells8020140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-17K09971
[Journal Article] Robust and highly efficient hiPSC generation from patient non-mobilized peripheral blood-derived CD34+ cells using the auto-erasable Sendai virus vector.2019
- Author(s)
  Okumura T, Horie Y, et al.
- Journal Title
  
  Stem Cell Res Ther.
  
  Volume: 10 Issue: 1 Pages: 185-185
- DOI
  10.1186/s13287-019-1273-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08246, KAKENHI-PROJECT-18K16141, KAKENHI-PROJECT-18H04053, KAKENHI-PROJECT-19H01052, KAKENHI-PROJECT-17K09971, KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-17K19600, KAKENHI-PROJECT-26000012
[Journal Article] Reduction of CD83 Expression on B Cells and the Genetic Basis for Rheumatoid Arthritis: Comment on the Article by Thalayasingam et al2018
- Author(s)
  Tsuchida Yumi、Sumitomo Shuji、Ota Mineto、Tsuchiya Haruka、Nagafuchi Yasuo、Shoda Hirofumi、Fujio Keishi、Ishigaki Kazuyoshi、Yamaguchi Kensuke、Suzuki Akari、Kochi Yuta、Yamamoto Kazuhiko
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: 70 Issue: 10 Pages: 1695-1696
- DOI
  10.1002/art.40652
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09972, KAKENHI-PROJECT-18K16140, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H05285
[Journal Article] Egr2-independent, Klf1-mediated induction of PD-L1 in CD4+ T cells.2018
- Author(s)
  Teruya S, Okamura T, Komai T, Inoue M, Iwasaki Y, Sumitomo S, Shoda H, Yamamoto K, Fujio K.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 7021-7021
- DOI
  10.1038/s41598-018-25302-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09971, KAKENHI-PROJECT-16K09918
[Journal Article] Transforming Growth Factor-β and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals.2018
- Author(s)
  Komai T, Inoue M, Okamura T, Morita K, Iwasaki Y, Sumitomo S, Shoda H, Yamamoto K, Fujio K.
- Journal Title
  
  Front Immunol
  
  Volume: 9 Pages: 1364-1364
- DOI
  10.3389/fimmu.2018.01364
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09971, KAKENHI-PROJECT-16K09918
[Journal Article] HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis.2018
- Author(s)
  Sakurai K, Ishigaki K, Shoda H, Nagafuchi Y, Tsuchida Y, Sumitomo S, Kanda H, Suzuki A, Kochi Y, Yamamoto K, Fujio K.
- Journal Title
  
  Journal of Rheumatology
  
  Volume: 45 Issue: 7 Pages: 905-914
- DOI
  10.3899/jrheum.170909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09971
[Journal Article] New horizons in clinical immunology: applications of induced pluripotent stem cells for the analysis of immune disorders.2018
- Author(s)
  Shoda H, Natsumoto B, Fujio K.
- Journal Title
  
  Immunol Med.
  
  Volume: 41 Issue: 1 Pages: 12-16
- DOI
  10.1080/09114300.2018.1451596
- Open Access
- Data Source
  KAKENHI-PROJECT-17K09971
[Journal Article] Identification of tonsillar CD4+CD25-LAG3+ T cells as naturally occurring IL-10-producing regulatory T cells in human lymphoid tissue.2017
- Author(s)
  Sumitomo S, Nakachi S, Okamura T, Tsuchida Y, Kato R, Shoda H, Furukawa A, Kitahara N, Kondo K, Yamasoba T, Yamamoto K, Fujio K.
- Journal Title
  
  Journal of Autoimmunity
  
  Volume: 76 Pages: 75-84
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461462
[Journal Article] Increased serum concentrations of IL-1 beta, IL-21 and Th17 cells in overweight patients with rheumatoid arthritis.2017
- Author(s)
  Shoda H, Nagafuchi Y, Tsuchida Y, Sakurai K, Sumitomo S, Fujio K, Yamamoto K.
- Journal Title
  
  Arthritis Res Ther.
  
  Volume: 19 Pages: 111-111
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09971
[Journal Article] Enhanced gut homing receptor expression of unswitched memory B cells in rheumatoid arthritis.2017
- Author(s)
  agafuchi Y, Shoda H, Sumitomo S, Nakachi S, Kato R, Tsuchida Y, Tsuchiya H, Sakurai K, Hanata N, Tateishi S, Kanda H, Fujio K, Yamamoto K.
- Journal Title
  
  Clin Exp Rheumatol
  
  Volume: 35 Pages: 354-355
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461462
[Journal Article] .Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis.2017
- Author(s)
  Ishigaki K, Kochi Y, Suzuki A, Tsuchida Y, Tsuchiya H, Sumitomo S, Yamaguchi K, Nagafuchi Y, Nakachi S, Kato R, Sakurai K, Shoda H, Ikari K, Taniguchi A, Yamanaka H, Miya F, Tsunoda T, Okada Y, Momozawa Y, Kamatani Y, Yamada R, Kubo M, Fujio K, Yamamoto K.
- Journal Title
  
  Nat Genet.
  
  Volume: 49 Pages: 1120-1125
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09971
[Journal Article] 1.Immune responses to Mycobacterium heat shock protein 70 accompany self-reactivity to human BiP in rheumatoid arthritis2016
- Author(s)
  Shoda H, Hanata N, Sumitomo S, Okamura T, Fujio K, Yamamoto K
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 22486-22486
- DOI
  10.1038/srep22486
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461462, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-25461493
[Journal Article] Immunophenotyping of rheumatoid arthritis reveals a linkage between HLA-DRB1 genotype, CXCR4 expression on memory CD4(+) T cells, and disease activity.2016
- Author(s)
  Nagafuchi Y, Shoda H, Sumitomo S, Nakachi S, Kato R, Tsuchida Y, Tsuchiya H, Sakurai K, Hanata N, Tateishi S, Kanda H, Ishigaki K, Okada Y, Suzuki A, Kochi Y, Fujio K, Yamamoto K
- Journal Title
  
  Scientific reports
  
  Volume: 6 Issue: 1 Pages: 29338-29338
- DOI
  10.1038/srep29338
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461462
[Journal Article] Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model2015
- Author(s)
  Seri Y, Shoda H, Suzuki A, Matsumoto I, Sumida T, Fujio K, Yamamoto K
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 13041-13041
- DOI
  10.1038/srep13041
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23229007
[Journal Article] A new T-cell activation mode for suboptimal doses of antigen under the full activation of T cells with different specificity.2015
- Author(s)
  Shibuya M, Fujio K, Shoda H, Okamura T, Okamoto A, Sumitomo S, Yamamoto K.
- Journal Title
  
  Europian Journal of Immunology
  
  Volume: in press Issue: 6 Pages: 1643-53
- DOI
  10.1002/eji.201444965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-23229007
[Journal Article] Autoantigen BiP-derived HLA-DR4 epitopes differentially recognized by effector and regulatory T cells in rheumatoid arthritis.2015
- Author(s)
  Shoda H, Fujio K, Sakurai K, Ishigaki K, Nagafuchi Y, Shibuya M, Sumitomo S, Okamura T, Yamamoto K
- Journal Title
  
  Arthritis and Rheumatology
  
  Volume: in press Issue: 5 Pages: 1171-81
- DOI
  10.1002/art.39054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-26461462
[Journal Article] TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses2015
- Author(s)
  Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 1-14
- DOI
  10.1038/ncomms7329
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J04186, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25860803, KAKENHI-PROJECT-25860804, KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-15H05787
[Journal Article] Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells2013
- Author(s)
  Iwasaki, Y.
- Journal Title
  
  Eur J Immunol
  
  Volume: undefined Issue: 4 Pages: 1063-73
- DOI
  10.1002/eji.201242942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590435, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23590343, KAKENHI-PROJECT-23659492, KAKENHI-PROJECT-23791106, KAKENHI-PLANNED-24118002, KAKENHI-PROJECT-24390246, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-24790990, KAKENHI-PROJECT-25460594, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25670459, KAKENHI-PROJECT-25860803
[Journal Article] Transcription factor early growth response 3 is associated with the TGF-β1 expression and the regulatory activity of CD4-positive T cells in vivo.2013
- Author(s)
  Sumitomo S, Fujio K, Okamura T, Morita K, Ishigaki K, Suzukawa K, Kanaya K, Kondo K, Yamasoba T, Furukawa A, Kitahara N, Shoda H, Shibuya M, Okamoto A, Yamamoto K.
- Journal Title
  
  J Immunol
  
  Volume: 191 Issue: 5 Pages: 2351-9
- DOI
  10.4049/jimmunol.1202106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-24790990, KAKENHI-PROJECT-25461470, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25670459, KAKENHI-PROJECT-25860804
[Journal Article] Autoantigen BiP and autoimmune diseases2012
- Author(s)
  Shoda H, et al
- Journal Title
  
  日本臨床免疫学会誌
  
  Volume: 35(1) Pages: 46-50
- NAID
  10030465607
- Data Source
  KAKENHI-PROJECT-22790926
[Journal Article] Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis2011
- Author(s)
  Shoda H, Fujio K, Shibuya M, Okamura T, Sumitomo S, Okamoto A, Sawada T, et al.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 13 Issue: 6 Pages: 1-12
- DOI
  10.1186/ar3520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277, KAKENHI-PROJECT-22591086, KAKENHI-PROJECT-22790926, KAKENHI-PROJECT-23791106
[Patent] ペプチド、及びそれを含む医薬組成物2013
- Inventor(s)
  山本一彦、藤尾圭志、庄田宏文
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2013-082683
- Filing Date
  2013-04-11
- Data Source
  KAKENHI-PROJECT-24790990
[Patent] ペプチド、及びそれを含む医薬組成物2013
- Inventor(s)
  山本　一彦、藤尾　圭志、庄田　宏文
- Industrial Property Rights Holder
  国立大学法人　東京大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-082683
- Filing Date
  2013-04-11
- Data Source
  KAKENHI-PROJECT-24790990
[Presentation] 膠原病の機能ゲノム学2022
- Author(s)
  庄田　宏文
- Organizer
  第86回日本皮膚科会学会東部支部学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08800
[Presentation] Functional analysis of rare variants associated with SLE using patients derived iPS cells2021
- Author(s)
  Bunki Natsumoto, Hirofumi Shoda, Yasuo Nagafuchi, Makoto Otsu, Kazuhiko Yamamoto, Hideki Taniguchi, Keishi Fujio
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-20K08800
[Presentation] 疾患特異的iPS細胞による臨床免疫研究2021
- Author(s)
  庄田宏文
- Organizer
  第65回日本リウマチ学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08800
[Presentation] SLE患者由来iPS細胞を用いたrare variantsの探索と免疫学的機序の解明2021
- Author(s)
  夏本文輝、庄田宏文
- Organizer
  第49回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-20K08800
[Presentation] 疾患特異的iPS細胞による全身性エリテマトーデス研究2020
- Author(s)
  庄田宏文
- Organizer
  第48回日本臨床免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08800
[Presentation] Identification and functional analysis of SLE rare variants using patients-derived iPS cells2020
- Author(s)
  夏本文輝、庄田宏文、藤尾圭志
- Organizer
  第64回日本リウマチ学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08800
[Presentation] 姉妹SLE患者由来iPS細胞及びゲノム編集技術を用いたrare variantsの探索と機能証明2019
- Author(s)
  夏本文輝, 庄田宏文, 林煥庭, 永渕泰雄, 大津真, 山本一彦, 谷口英樹, 藤尾圭志
- Organizer
  第47回　日本臨床免疫学会　学術集会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] SLE Pathogenesis　Padi4 contributes to the development of mouse model of lupus nephritis via promoting neutrophil infiltration into kidney2019
- Author(s)
  Hanata Norio, Shoda Hirofumi, Hatano Hiroaki, Nagafuchi Yasuo, Komai Toshihiko, Okamura Tomohisa, Yamamoto Kazuhiko, Fujio Keishi
- Organizer
  第63回　日本リウマチ学会　学術集会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] PAD4により制御される好中球のp38 MAPK経路がループスモデルマウスにおいて免疫複合体沈着を伴う腎炎発症に寄与する2019
- Author(s)
  花田徳大, 庄田宏文, 波多野裕明, 永渕泰雄, 駒井俊彦, 岡村僚久, 鈴木亜香里, 善岡克次, 山本一彦, 藤尾圭志
- Organizer
  第47回　日本臨床免疫学会　学術集会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] Peptidylarginine deiminase 4 deficiency ameliorated imiquimod-induced lupus mice model2018
- Author(s)
  Hanata N, Shoda H, Komai T, Okamura T, Yamamoto K, Fujio K
- Organizer
  第62回日本リウマチ学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] Peptidylarginine deimiase 4欠損により腎臓への好中球浸潤が減少しループスモデルにおける腎炎が改善する2018
- Author(s)
  花田徳大, 庄田宏文, 波多野裕明, 永渕泰雄, 駒井俊彦, 岡村僚久, 鈴木亜香里, 山本一彦, 藤尾圭志
- Organizer
  第46回日本臨床免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] The possibility of induced pluripotent stem cells for investigation of autoimmune diseases2018
- Author(s)
  庄田宏文
- Organizer
  第47回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] Pathophysiological research of systemic lupus erythematosus(SLE) using SLE patient-derived iPS cells with genome editing approach2018
- Author(s)
  Natsumoto B, Shoda H, Lin HT, Lai YL, Nagafuchi Y, Otsu M, Yamamoto K, Fujio K
- Organizer
  第62回日本リウマチ学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] The effects of peptidylarginine deiminase 4 in imiquimod-induced lupus model mice.2017
- Author(s)
  花田徳大、庄田宏文、駒井俊彦、岡村僚久、鈴木亜香里、山本一彦、藤尾圭志.
- Organizer
  第46回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] Effects of peptidylarginine deiminase inhibition in imiquimod-induced lupus-like model mice.2017
- Author(s)
  花田徳大、庄田宏文、駒井俊彦、岡村僚久、藤尾圭志、山本一彦.
- Organizer
  第61回日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] 全身性エリテマトーデス(SLE)疾患特異的iPS細胞を用いたSLE病態解明研究.2017
- Author(s)
  夏本文輝、庄田宏文、林煥庭、頼貞儀、永渕泰雄、石垣和慶、高地雄太、大津真、山本一彦、藤尾圭志.
- Organizer
  第45回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] Characterization of immune cells differentiated from SLE patient-derived Induced Pluripotent Stem Cells.2017
- Author(s)
  夏本文輝、庄田宏文、林煥庭、頼貞儀、石垣和慶、高地雄太、藤尾圭志、大津真、山本一彦.
- Organizer
  第61回日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] 全身性エリテマトーデス(SLE)疾患特異的iPS細胞を用いたSLE病態解明研究.2017
- Author(s)
  夏本文輝、庄田宏文、林煥庭、頼貞儀、永渕泰雄、石垣和慶、高地雄太、大津真、山本一彦、藤尾圭志.
- Organizer
  第38回炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] Peptidylarginine deiminase 4欠損がImiquimod誘発ループスモデルマウスにおける病態を改善させる.2017
- Author(s)
  花田徳大、庄田宏文、駒井俊彦、岡村僚久、鈴木亜香里、山本一彦、藤尾圭志.
- Organizer
  第45回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] Pathophysiological analysis of systemic lupus erythematosus (SLE) using patient-derived induced pluripotent stem cells.2017
- Author(s)
  夏本文輝、庄田宏文、林煥庭、頼貞儀、永渕泰雄、石垣和慶、高地雄太、山本一彦、大津真、藤尾圭志
- Organizer
  第46回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] Immunological phenotyping of obese patients with rheumatoid arthritis2017
- Author(s)
  庄田宏文、永渕泰雄、土田優美、櫻井恵一、住友秀次、藤尾圭志、山本　一彦.
- Organizer
  第61回日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] The role of PADs in rheumatoid arthritis.2017
- Author(s)
  Hirofumi Shoda
- Organizer
  International forum for RA
- Invited
- Data Source
  KAKENHI-PROJECT-17K09971
[Presentation] Analysis of T cell repertoire diversity of CD4+ T cells　by next generation sequencing and its association　with clinical parameters in rheumatoid arthritis2016
- Author(s)
  Sakurai S, Shoda H, Ishigaki K, Fujio K, Yamamoto K
- Organizer
  Annual meeting of American College of Rheumatology
- Place of Presentation
  米国・ワシントン
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461462
[Presentation] Immune responses to Mycobacterium heat shock protein 70 accompany2015
- Author(s)
  Shoda H
- Organizer
  Annual meeting of American College of Rheumatology
- Place of Presentation
  サンフランシスコ(USA)
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461462
[Presentation] autoantigen Bip-specific regulatory T cells in rheumatoid arthritis and thier therapeutic application2013
- Author(s)
  庄田　宏文
- Organizer
  第57回日本リウマチ学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24790990
[Presentation] 関節リウマチにおける抗原特異的T細胞応答2013
- Author(s)
  庄田宏文
- Organizer
  第41回臨床免疫学会総会
- Place of Presentation
  海峡メッセ(山口県下関市)
- Year and Date
  2013-11-29
- Data Source
  KAKENHI-PROJECT-24790990
[Presentation] autoantigen Bip-specific CD4+ T cells in rheumatoid arthritis2013
- Author(s)
  庄田宏文、藤尾圭志、山本一彦
- Organizer
  第50回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム(東京都中央区)
- Year and Date
  2013-04-11
- Data Source
  KAKENHI-PROJECT-24790990
[Presentation] autoantigen Bip-specific regulatory T cells in rheumatoid arthritis and thier therapeutic application2013
- Author(s)
  庄田宏文、藤尾圭志、山本一彦
- Organizer
  第57回日本リウマチ学会総会
- Place of Presentation
  京都国際会議場(京都府京都市)
- Year and Date
  2013-04-18
- Data Source
  KAKENHI-PROJECT-24790990
[Presentation] Impaired homeostatic balance between autoantigen BiP-specific effector and regulatory T cells in rheumatoid arthritis2012
- Author(s)
  庄田　宏文
- Organizer
  第41回日本免疫学会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24790990
[Presentation] Impaired homeostatic balance between autoantigen BiP-specific effector and regulatory T cells in rheumatoid arthritis2012
- Author(s)
  庄田宏文、藤尾圭志、山本一彦
- Organizer
  第41回日本免疫学会総会
- Place of Presentation
  神戸国際会議場(兵庫県神戸市)
- Year and Date
  2012-12-05
- Data Source
  KAKENHI-PROJECT-24790990
[Presentation] Autoantigen BiP-specific CD4+T cells in rheumatoid arthritis and systemic lupus erythematosus patients2011
- Author(s)
  庄田宏文他
- Organizer
  第40回日本免疫学会
- Place of Presentation
  幕張メッセ
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22790926
[Presentation] 自己BiP由来epitopeを認識するCD4陽性T細胞の健常人・関節リウマチ患者における表現型2011
- Author(s)
  庄田宏文他
- Organizer
  第55回日本リウマチ学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2011-07-19
- Data Source
  KAKENHI-PROJECT-22790926
[Presentation] Autoantigen BiP-specific CD4+ T cells in rheumatoid arthritis and systemic lupus erythematosus patients2011
- Author(s)
  庄田宏文, ほか
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22790926
[Presentation] Identification of autoantigen BiP-derived HLA-DR4 epitope and its pathological roles in rheumatoid arthritis2010
- Author(s)
  庄田宏文
- Organizer
  第14回国際免疫学会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22790926
[Presentation] Identification of autoantigen BiP-derived HLA-DR4 epitope and its pathological roles in rheumatoid arthritis2010
- Author(s)
  庄田宏文他
- Organizer
  第14回国際免疫学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22790926
[Presentation] 関節リウマチにおける抗原特異的T細胞応答
- Author(s)
  庄田　宏文
- Organizer
  第41回臨床免疫学会総会
- Place of Presentation
  海峡メッセ
- Data Source
  KAKENHI-PROJECT-24790990
[Presentation] autoantigen Bip-specific CD4+ T cells in rheumatoid arthritis
- Author(s)
  庄田　宏文、藤尾　圭志、山本　一彦
- Organizer
  第50回日本臨床分子医学会学術集会.
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24790990
[Presentation] autoantigen Bip-specific regulatory T cells in rheumatoid arthritis and thier therapeutic application.
- Author(s)
  庄田　宏文、藤尾　圭志、山本　一彦
- Organizer
  第57回日本リウマチ学会総会.
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-24790990
[]

1. YAMAMOTO KAZUHIKO (80191394)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. OKAMURA TOMOHISA (10528996)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. 岡本明子 (40431861)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. SUMITOMO SHUJI (20392996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. SHIBUYA MIHOKO (20366363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. IWASAKI YUKIKO (30592935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 鈴木亜香里 (00391996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 尾崎浩一 (50373288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 寺尾知可史 (60610459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAGAFUCHI Yasumo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. SAKURAI Keiichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. FUJIO Keishi

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
13. 小林聖未

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHODA HIROFUMI 庄田 宏文

SHODA Hirofumi 庄田 宏文

Research Projects

Research Products

Co-Researchers

iPS細胞を活用した自己免疫疾患病態研究推進のためのスキーム策定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of iPS cell-based strategy for elucidating the pathogenesis of autoimmune diseases and discovery of therapeutic targetsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a novel strategy for pathological analysis of multifactorial diseases using genetic risk variants

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of novel therapeutic targets in dendritic cells for systemic lupus erythematosusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Antigen specific therapy for rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of novel therapeutic strategies for rheumatoid arthritis by reguIation of autoantigen-specific T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of rheumatoid arthritis-directed human immunology

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

関節リウマチにおける自己抗原とそれに対する免疫応答制御

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of antigen specific therapy for rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dysregulation of the gene signature of effector regulatory T cells in the early phase of systemic sclerosis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Control of naive and effector CD4 T cell receptor repertoires by rheumatoid-arthritis-risk HLA alleles2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct transcriptome architectures underlying lupus establishment and exacerbation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum extracellular traps associate with the activation of myeloid cells in SLE patients with the low level of anti-DNA antibodies2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci2022

SHODA HIROFUMI 庄田宏文

SHODA Hirofumi 庄田宏文