Kumashiro Naoki 熊代尚記

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KUMASHIRO Naoki 熊代尚記

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Researcher Number	20535207
Other IDs
Affiliation (Current)	2025: 金沢医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2024: 金沢医科大学, 医学部, 教授 2021 – 2022: 金沢医科大学, 医学部, 教授 2018 – 2020: 東邦大学, 医学部, 准教授 2014 – 2017: 東邦大学, 医学部, 講師 2013 – 2014: 東邦大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Applied health science / Metabolomics Except Principal Investigator Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator 非アルコール性脂肪肝 / 肝インスリン感受性 / 肝臓体積 / インスリン感受性 / 脂肪肝 / 脂肪組織インスリン感受性 / インスリン抵抗性 / 脂肪との共存 / 肝臓実質体積 / 肝脂肪 … More / 除脂肪肝臓体積 / 肝脂肪量 / 生活習慣病 / 筋インスリン感受性 / 解析 / 脂肪蓄積 / 肝臓 / 高分子アディポネクチン / 非アルコール脂肪肝 / マウス / 耐糖能異常 / 睡眠障害 … More Except Principal Investigator 介入法 / 糖尿病 / 生活の質 / アンケート調査 / 睡眠障害 / 2型糖尿病 Less

脂肪との共存の実現へ向けたSLC28A1の予防・治療標的としての可能性の追究Principal Investigator
- Principal Investigator
  
  熊代尚記
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kanazawa Medical University
Exploration of hepatic parenchymal regulatory mechanisms to realize diabetes suppression strategy via coexistence with fatPrincipal Investigator
- Principal Investigator
  
  KUMASHIRO Naoki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kanazawa Medical University
  Toho University
Investigation on methods of intervention in sleep disorder improving QOL of diabetes patients
- Principal Investigator
  
  HIROSE Takahisa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Toho University
Investigation on how to adjust fatty liver metabolically for suppression of diabetesPrincipal Investigator
- Principal Investigator
  
  KUMASHIRO Naoki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Toho University
Investigation on how to prevent type 2 diabetes by the tolerance to adiposityPrincipal Investigator
- Principal Investigator
  
  KUMASHIRO Naoki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Applied health science
- Research Institution
  Toho University
睡眠障害によるインスリン抵抗性発症機序の解明Principal Investigator
- Principal Investigator
  
  熊代尚記
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Metabolomics
- Research Institution
  Toho University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Empagliflozin versus sitagliptin for ameliorating intrahepatic lipid content and tissue‐specific insulin sensitivity in patients with early‐stage type 2 diabetes with non‐alcoholic fatty liver disease: A prospective randomized study2023
- Author(s)
  Hiruma Shigenori、Shigiyama Fumika、Kumashiro Naoki
- Journal Title
  
  Diabetes, Obesity and Metabolism
  
  Volume: - Issue: 6 Pages: 1576-1588
- DOI
  10.1111/dom.15006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H04112
[Journal Article] A prospective randomized study comparing effects of empagliflozin to sitagliptin on cardiac fat accumulation, cardiac function, and cardiac metabolism in patients with early-stage type 2 diabetes: the ASSET study2021
- Author(s)
  Hiruma S, Shigiyama F, Hisatake S, Mizumura S, Shiraga N, Hori M, Ikeda T, Hirose T, Kumashiro N
- Journal Title
  
  Cardiovascular Diabetology
  
  Volume: 20 Issue: 1 Pages: 32-32
- DOI
  10.1186/s12933-021-01228-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04112
[Journal Article] Simplification of complex insulin regimens using canagliflozin or liraglutide in patients with well‐controlled type 2 diabetes: A 24‐week randomized controlled trial2021
- Author(s)
  Ando Yasuyo、Shigiyama Fumika、Hirose Takahisa、Kumashiro Naoki
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 12 Issue: 10 Pages: 1816-1826
- DOI
  10.1111/jdi.13533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H04112
[Journal Article] Changes in subjective sleep quality in patients with type 2 diabetes who did not use Sleep agents: a cross-sectional study according to age and clinical background2021
- Author(s)
  Yoshikawa Fukumi、Kumashiro Naoki、Shigiyama Fumika、Miyagi Masahiko、Ando Yasuyo、Uchino Hiroshi、Hirose Takahisa
- Journal Title
  
  Diabetology International
  
  Volume: 13 Issue: 1 Pages: 142-147
- DOI
  10.1007/s13340-021-00516-3
- NAID
  40022802881
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H04112
[Journal Article] 脂肪との共存を実現する肝インスリン感受性保持機構の追究2020
- Author(s)
  熊代尚記, 鴫山文華, 五十嵐弘之, 蛭間重典, 弘世貴久
- Journal Title
  
  糖尿病合併症
  
  Volume: 34 Pages: 186-193
- Data Source
  KAKENHI-PROJECT-20H04112
[Journal Article] Whole hepatic lipid volume quantification and color mapping by multi-slice and multi-point magnetic resonance imaging2019
- Author(s)
  Igarashi H, Shigiyama F, Wakui N, Nagai H, Shibuya K, Shiraga N, Hirose T, Kumashiro N
- Journal Title
  
  Hepatol Res
  
  Volume: 2019 Dec Issue: 12 Pages: 1374-1385
- DOI
  10.1111/hepr.13408
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16213, KAKENHI-PROJECT-17H02180
[Journal Article] メトホルミンの肝臓におけるミトコンドリア complex I 阻害非依存性作用2019
- Author(s)
  渕上彩子, 鴫山文華, 熊代尚記
- Journal Title
  
  内分泌・糖尿病・代謝内科
  
  Volume: 49 Pages: 376-380
- Open Access
- Data Source
  KAKENHI-PROJECT-17H02180
[Journal Article] Mechanisms of sleep deprivation-induced hepatic steatosis and insulin resistance in mice2018
- Author(s)
  Shigiyama F, Kumashiro N, Tsuneoka Y, Igarashi H, Yoshikawa F, Kakehi S, Funato H, Hirose T
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 315 Issue: 5 Pages: E848-E858
- DOI
  10.1152/ajpendo.00072.2018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16213, KAKENHI-PUBLICLY-17H05583, KAKENHI-PROJECT-17H02180, KAKENHI-PROJECT-17H04023
[Journal Article] Characteristics of hepatic insulin-sensitive nonalcoholic fatty liver disease.2017
- Author(s)
  Shigiyama F, Kumashiro N, Furukawa Y, Funayama T, Takeno K, Wakui N, Ikehara T, Nagai H, Taka H, Fujimura T, Uchino H, Tamura Y, Watada H, Nemoto T, Shiraga N, Sumino Y, Hirose T.
- Journal Title
  
  Hepatol Commun.
  
  Volume: 1 Issue: 7 Pages: 634-647
- DOI
  10.1002/hep4.1077
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-17K00874, KAKENHI-PROJECT-17H02180
[Presentation] 異所性脂肪蓄積と組織特異的インスリン感受性に着目したNAFLD合併早期２型糖尿病の治療戦略2022
- Author(s)
  蛭間重典, 鴫山文華, 和久井紀貴, 渕上彩子, 白神伸之, 堀正明, 田村好史, 綿田裕孝, 弘世貴久, 熊代尚記
- Organizer
  第8回肝臓と糖尿病・代謝研究会
- Data Source
  KAKENHI-PROJECT-20H04112
[Presentation] 減量困難な状況から生まれた，脂肪との共存の追究(特別講演)2022
- Author(s)
  熊代尚記
- Organizer
  金沢医科大学医学会第57回学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H04112
[Presentation] 日本人非アルコール性脂肪肝における肝インスリン感受性規定因子の探索2022
- Author(s)
  鴫山文華, 蛭間重典, 熊代尚記
- Organizer
  第43回日本肥満学会・第40回日本肥満症治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04112
[Presentation] 異所性脂肪蓄積と組織特異的インスリン感受性に着目したNAFLD合併早期2型糖尿病の治療戦略(柳瀬武司奨学基金受賞講演)2022
- Author(s)
  蛭間重典, 鴫山文華, 和久井紀貴, 渕上彩子, 白神伸之, 堀　正明, 田村好史, 綿田裕孝, 弘世貴久, 熊代尚記
- Organizer
  第160回東邦医学会例会
- Data Source
  KAKENHI-PROJECT-20H04112
[Presentation] 脂肪肝・インスリン抵抗性に対するRho family GTPase2抑制効果の検討2022
- Author(s)
  鴫山文華, 小林瑠璃, 中村直美, 渕上彩子, 弘世貴久, 熊代尚記
- Organizer
  第95回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04112
[Presentation] 非アルコール性脂肪肝における肝インスリン感受性保持機構の追究(シンポジウム)2022
- Author(s)
  熊代尚記
- Organizer
  第43回日本肥満学会・第40回日本肥満症治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H04112
[Presentation] 脂肪肝とインスリン感受性研究の17年間を振り返って2021
- Author(s)
  熊代尚記
- Organizer
  第58回日本糖尿病学会関東甲信越地方会
- Invited
- Data Source
  KAKENHI-PROJECT-20H04112
[Presentation] 層別解析による2型糖尿病における主観的睡眠関連指標の年代別変化および臨床背景の検討.2020
- Author(s)
  吉川芙久美, 熊代尚記, 鴫山文華, 宮城匡彦, 安藤恭代, 内野泰, 弘世貴久
- Organizer
  第63回日本糖尿病学会年次学術集会, Web開催, 2020.10
- Data Source
  KAKENHI-PROJECT-18K07481
[Presentation] 日本人NAFLDの網羅的解析による新規の肝インスリン感受性規定因子、徐脂肪肝臓体積の同定2020
- Author(s)
  鴫山文華、五十嵐弘之、蛭間重典、弘世貴久、熊代尚記
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04112
[Presentation] 日本人NAFLDの網羅的解析による新規の肝インスリン感受性規定因子、徐脂肪肝臓体積の同定2020
- Author(s)
  鴫山文華、熊代尚記、蛭間重典、渕上彩子、弘世貴久
- Organizer
  第21回日本内分泌学会関東甲信越支部学術集会
- Data Source
  KAKENHI-PROJECT-20H04112
[Presentation] Impact of hepatic elovl3 on sleep deprivation induced hepatic steatosis and glucose intolerance2020
- Author(s)
  Shigiyama F, Fuchigami A, Hirose T, Kumashiro N
- Organizer
  56th Annual Meeting of the European Association for the Study of Diabetes (EASD)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04112
[Presentation] Comparison of empagliflozin and sitagliptin on ectopic fat accumulation and tissue-specific insulin sensitivity2020
- Author(s)
  Hiruma S, Shigiyama F, Hisatake S, Mizumura S, Shiraga N, Hori M, Ikeda T, Hirose T, Kumashiro N
- Organizer
  80th American Diabetes Association Scientific Sessions (ADA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04112
[Presentation] 脂肪との共存を実現する肝インスリン感受性保持機構の追究2019
- Author(s)
  熊代尚記
- Organizer
  第34回日本糖尿病合併症学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02180
[Presentation] Impact of lean hepatic volume on hepatic insulin resistance in human NAFLD2019
- Author(s)
  Igarashi H, Shigiyama F, Hiruma S, Hirose T, Kumashiro N
- Organizer
  79th American Diabetes Association Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02180
[Presentation] 日本人NAFLDの網羅的解析による新規の肝インスリン感受性規定因子、徐脂肪肝臓体積の同定2019
- Author(s)
  鴫山文華、熊代尚記、五十嵐弘之、蛭間重典、渋谷和俊、弘世貴久
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H02180
[Presentation] 脂肪との共存を実現する肝インスリン感受性保持機構の追究2019
- Author(s)
  熊代尚記
- Organizer
  第69回日本体質医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02180
[Presentation] Mechanisms of Hepatic Steatosis and Insulin Resistance Induced by Sleep Deprivation in Mice2018
- Author(s)
  Shigiyama F, Kumashiro N, Yoshikawa F, Tsuneoka Y, Funato H, Hirose T
- Organizer
  78th Scientific Sessions American Diabetes Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02180
[Presentation] 肝脂肪蓄積時の肝インスリン感受性保持機構の探求2018
- Author(s)
  鴫山文華、熊代尚記、弘世貴久
- Organizer
  第36回内分泌代謝学サマーセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17H02180
[Presentation] 急性睡眠障害が過食・肥満とは独立して肝脂肪蓄積を誘発する2017
- Author(s)
  鴫山文華、熊代尚記、吉川芙久美、恒岡洋右、船戸弘正、弘世貴久
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール　ヴィアマーレ（神奈川県横浜市）
- Year and Date
  2017-02-11
- Data Source
  KAKENHI-PROJECT-26702032
[Presentation] 超高齢社会での糖尿病対策を考える2017
- Author(s)
  熊代尚記
- Organizer
  第9回抗加齢内分泌研究会（日本抗加齢医学会分科会）
- Invited
- Data Source
  KAKENHI-PROJECT-17H02180
[Presentation] Mitochondria TCA Cycle and Adiponectin Are Associated with Preserved Hepatic Insulin Sensitivity in NAFLD Patients2016
- Author(s)
  Shigiyama F，Kumashiro N，Furukawa Y，Funayama T，Takano K，Shiraga N，Sumino Y，Tamura Y，Kawamori R，Watada H，Hirose T
- Organizer
  76th Scientific Sessions American Dibetes Association(ADA)
- Place of Presentation
  New Orleans（USA）
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26702032
[Presentation] 日本人NAFLD患者の肝インスリン感受性保持因子として、アディポネクチンとミトコンドリアクエン酸回路が関与する2016
- Author(s)
  鴫山文華、熊代尚記、古川康彦、船山崇、竹野景海、白神伸之、佐野泰清、田村好史、河盛隆造、綿田裕孝、弘世貴久
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-26702032
[Presentation] 急性睡眠障害が過食・肥満とは独立して肝脂肪蓄積を誘発する2016
- Author(s)
  鴫山文華、熊代尚記、恒岡洋右、船戸弘正、弘世貴久
- Organizer
  第89回日本内分泌学会学術総会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-26702032
[Presentation] 急性睡眠障害が過食・肥満とは独立して肝脂肪蓄積を誘発する2016
- Author(s)
  鴫山文華、熊代尚記、藤村梓、恒岡洋右、船戸弘正、弘世貴久
- Organizer
  第34回内分泌代謝学サマーセミナー
- Place of Presentation
  久山温泉　ホテル夢家（福岡県糟屋郡久山町）
- Year and Date
  2016-07-15
- Data Source
  KAKENHI-PROJECT-26702032
[Presentation] 日本人NAFLD患者と肝インスリン感受性保持因子として、アディポネクチンとミトコンドリアクエン酸回路が関与する2016
- Author(s)
  鴫山文華、熊代尚記、古川康彦、船山崇、竹野景海、根本哲生、白神伸之、住野泰清、田村好史、河盛隆造、綿田裕孝、弘世貴久
- Organizer
  第66回日本体質医学会総会
- Place of Presentation
  和歌山県JAビル（和歌山県和歌山市）
- Year and Date
  2016-09-03
- Data Source
  KAKENHI-PROJECT-26702032
[Presentation] 急性睡眠障害が過食・肥満と独立して肝脂肪蓄積を誘発する2016
- Author(s)
  鴫山文華、熊代尚記、吉川芙久美、恒岡洋右、船戸弘正、弘世貴久
- Organizer
  第28回分子糖尿病学シンポジウム
- Place of Presentation
  タワー111（富山県富山市）
- Year and Date
  2016-12-03
- Data Source
  KAKENHI-PROJECT-26702032
[Presentation] 日本人NAFLDの網羅的解析に基づいた脂肪肝における肝インスリン感受性保持因子の探究2016
- Author(s)
  鴫山文華、熊代尚記、古川康彦、船山崇、竹野景海、根本哲生、白神伸之、住野泰清、田村好史、河盛隆造、綿田裕孝、弘世貴久
- Organizer
  第3回肝臓と糖尿病・代謝研究会
- Place of Presentation
  石川県立音楽堂（石川県金沢市）
- Year and Date
  2016-07-16
- Data Source
  KAKENHI-PROJECT-26702032
[Presentation] 脂肪組織インスリン感受性ならびにアディポネクチンは日本人NAFLD患者の肝インスリン感受性保持に関与する2016
- Author(s)
  鴫山文華、熊代尚記、古川康彦、船山崇、竹野景海、根本哲生、白神伸之、住野泰清、田村好史、河盛隆造、綿田裕孝、弘世貴久
- Organizer
  第21回アディポサイエンス・シンポジウム
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Year and Date
  2016-08-20
- Data Source
  KAKENHI-PROJECT-26702032
[Presentation] 1型糖尿病に合併した多嚢胞卵巣症候群に対する低用量メトホルミン治療の効果2016
- Author(s)
  力武崇之・熊代尚記
- Organizer
  第147回東邦医学会例会
- Place of Presentation
  東邦大学（東京都大田区）
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-26702032
[Presentation] 肝脂肪とインスリン抵抗性について、脂肪悪説の研究に基づいた〝脂肪との共存”の提唱2016
- Author(s)
  熊代尚記、鴫山文華、弘世貴久
- Organizer
  第34回内分泌代謝学サマーセミナー
- Place of Presentation
  久山温泉　ホテル夢家（福岡県糟屋郡久山町）
- Year and Date
  2016-07-15
- Data Source
  KAKENHI-PROJECT-26702032
[Presentation] 非アルコール性脂肪肝におけるインスリン抵抗性の病態と脂肪酸のエステル化の意義2015
- Author(s)
  熊代尚記・鴫山文華
- Organizer
  第2回肝臓と糖尿病・代謝研究会
- Place of Presentation
  シーモールパレス（山口県下関市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-26702032
[Presentation] メトロホルミンが奏功した、早期1型糖尿病合併、非肥満PCOSの一例2015
- Author(s)
  熊代尚記
- Organizer
  第25回臨床内分泌代謝Update
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-26702032

1. 鴫山文華 (70808188)

# of Collaborated Projects: 4 results

# of Collaborated Products: 27 results
2. HIROSE Takahisa (40384119)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
3. 和久井紀貴 (20385933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 野崎雄一 (80468165)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TAKA Hikari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. NEMOTO takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kumashiro Naoki 熊代 尚記

KUMASHIRO Naoki 熊代 尚記

Research Projects

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Co-Researchers

脂肪との共存の実現へ向けたSLC28A1の予防・治療標的としての可能性の追究Principal Investigator

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Exploration of hepatic parenchymal regulatory mechanisms to realize diabetes suppression strategy via coexistence with fatPrincipal Investigator

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Investigation on methods of intervention in sleep disorder improving QOL of diabetes patients

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Investigation on how to adjust fatty liver metabolically for suppression of diabetesPrincipal Investigator

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Investigation on how to prevent type 2 diabetes by the tolerance to adiposityPrincipal Investigator

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睡眠障害によるインスリン抵抗性発症機序の解明Principal Investigator

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[Journal Article] Empagliflozin versus sitagliptin for ameliorating intrahepatic lipid content and tissue‐specific insulin sensitivity in patients with early‐stage type 2 diabetes with non‐alcoholic fatty liver disease: A prospective randomized study2023

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[Journal Article] A prospective randomized study comparing effects of empagliflozin to sitagliptin on cardiac fat accumulation, cardiac function, and cardiac metabolism in patients with early-stage type 2 diabetes: the ASSET study2021

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[Journal Article] Simplification of complex insulin regimens using canagliflozin or liraglutide in patients with well‐controlled type 2 diabetes: A 24‐week randomized controlled trial2021

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[Journal Article] Changes in subjective sleep quality in patients with type 2 diabetes who did not use Sleep agents: a cross-sectional study according to age and clinical background2021

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[Journal Article] 脂肪との共存を実現する肝インスリン感受性保持機構の追究2020

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[Journal Article] Whole hepatic lipid volume quantification and color mapping by multi-slice and multi-point magnetic resonance imaging2019

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[Journal Article] メトホルミンの肝臓におけるミトコンドリア complex I 阻害非依存性作用2019

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[Journal Article] Mechanisms of sleep deprivation-induced hepatic steatosis and insulin resistance in mice2018

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Kumashiro Naoki 熊代尚記

KUMASHIRO Naoki 熊代尚記